MCID: FLL029
MIFTS: 41

Fallopian Tube Disease

Categories: Reproductive diseases

Aliases & Classifications for Fallopian Tube Disease

MalaCards integrated aliases for Fallopian Tube Disease:

Name: Fallopian Tube Disease 12 15 17
Fallopian Tube Diseases 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1962
MeSH 44 D005184
NCIt 50 C26771
SNOMED-CT 67 128134005
UMLS 70 C0015556

Summaries for Fallopian Tube Disease

Disease Ontology : 12 A female reproductive system disease that is located in the fallopian tube.

MalaCards based summary : Fallopian Tube Disease, also known as fallopian tube diseases, is related to salpingitis and fallopian tube carcinoma. An important gene associated with Fallopian Tube Disease is SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Povidone-iodine and Povidone have been mentioned in the context of this disorder. Affiliated tissues include fallopian tube, uterus and ovary, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 73 The Fallopian tubes, also known as uterine tubes, salpinges (singular salpinx), or oviducts, are tubes... more...

Related Diseases for Fallopian Tube Disease

Diseases related to Fallopian Tube Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 630)
# Related Disease Score Top Affiliating Genes
1 salpingitis 32.0 TNF SIGLEC5 IL6 CEACAM1 CD4
2 fallopian tube carcinoma 30.1 TP53 RAD51D RAD51C BRCA2 BRCA1
3 fallopian tube clear cell adenocarcinoma 10.5 BRCA2 BRCA1
4 acute gonococcal endometritis 10.5 CEACAM1 CD4
5 ovary transitional cell carcinoma 10.5 BRCA2 BRCA1
6 cancerophobia 10.5 BRCA2 BRCA1
7 nosophobia 10.5 BRCA2 BRCA1
8 anal carcinoma in situ 10.5 TP53 CD4
9 tetraploidy 10.4 BRCA2 BRCA1
10 b-lymphoblastic leukemia/lymphoma with hyperdiploidy 10.4 BRCA2 BRCA1
11 ruvalcaba syndrome 10.4 BRCA2 BRCA1
12 basaloid lung carcinoma 10.4 TP53 BRCA2 BRCA1
13 ophthalmia neonatorum 10.4 SIGLEC5 MTRR CEACAM3
14 cervical adenoma malignum 10.4 TP53 BRCA2 BRCA1
15 mutagen sensitivity 10.4 TP53 BRCA2 BRCA1
16 synchronous bilateral breast carcinoma 10.4 TP53 BRCA2 BRCA1
17 hypertrophy of breast 10.4 TP53 BRCA2 BRCA1
18 female reproductive endometrioid cancer 10.4 TP53 BRCA2 BRCA1
19 abacavir allergy 10.4 CD4 CCR5
20 external pathological resorption 10.4 TNF IL6
21 acute retinal necrosis syndrome 10.4 SIGLEC5 IL6 CD4
22 papillary serous adenocarcinoma 10.4 TP53 BRCA2 BRCA1
23 chancroid 10.4 CD4 CCR6 CCR5
24 lobular neoplasia 10.4 TP53 BRCA2 BRCA1
25 thoracic benign neoplasm 10.4 TP53 BRCA2 BRCA1
26 breast benign neoplasm 10.4 TP53 BRCA2 BRCA1
27 herpes simplex virus keratitis 10.4 CXCL8 CD4 CCR6
28 scorpion envenomation 10.4 TNF IL6
29 t-cell adult acute lymphocytic leukemia 10.4 TP53 CD4 CCR6
30 scabies 10.4 CXCL8 CD4 CCR6
31 blastomycosis 10.4 IL6 CD4 CCR6
32 ovarian cystadenocarcinoma 10.4 TP53 BRCA2 BRCA1
33 mycobacterium marinum 10.4 CXCL8 CAMP
34 sapho syndrome 10.4 TP53 SIGLEC5 CXCL8
35 uterine corpus cancer 10.4 TP53 BRCA2 BRCA1
36 hyper ige recurrent infection syndrome 1 10.4 IL6 CD4 CCR6
37 familial ovarian cancer 10.4 RAD51C BRCA2 BRCA1
38 papillon-lefevre syndrome 10.4 SIGLEC5 CCR6 CAMP
39 acute cervicitis 10.4 CXCL8 CEACAM1
40 myasthenic syndrome, congenital, 6, presynaptic 10.4 TP53 BRCA2 BRCA1
41 farmer's lung 10.4 TNF SLPI CD4
42 acute transverse myelitis 10.4 IL6 CXCL8
43 cystadenocarcinoma 10.4 TP53 CEACAM3 BRCA1
44 tuberculoid leprosy 10.4 TNF CD4 CCR6
45 acute proliferative glomerulonephritis 10.3 TNF CD4 CCR6
46 autoimmune disease of peripheral nervous system 10.3 IL6 CD4 CCR6
47 acute gonococcal cervicitis 10.3 IL6 CXCL8 CEACAM1
48 thymus gland disease 10.3 TP53 CD4 CCR6
49 rheumatoid arthritis interstitial lung disease 10.3 TNF CD4
50 retinal vasculitis 10.3 TNF CD4 CCR6

Graphical network of the top 20 diseases related to Fallopian Tube Disease:



Diseases related to Fallopian Tube Disease

Symptoms & Phenotypes for Fallopian Tube Disease

GenomeRNAi Phenotypes related to Fallopian Tube Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.5 BRCA1 BRCA2 CXCL8 IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.5 BRCA1 BRCA2 CXCL8 IL1B TNF TP53
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.5 BRCA1 BRCA2 RAD51D TP53

MGI Mouse Phenotypes related to Fallopian Tube Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 BRCA1 BRCA2 CAMP CCR5 CCR6 CD4
2 homeostasis/metabolism MP:0005376 10.1 BRCA1 BRCA2 CCR5 CCR6 CD4 CEACAM1
3 digestive/alimentary MP:0005381 10.02 BRCA1 BRCA2 CCR5 CD4 CEACAM1 IL6
4 immune system MP:0005387 9.97 BRCA1 BRCA2 CAMP CCR5 CCR6 CD4
5 mortality/aging MP:0010768 9.8 BRCA1 BRCA2 CAMP CCR5 CD4 CEACAM1
6 neoplasm MP:0002006 9.28 BRCA1 BRCA2 CCR5 CEACAM1 IL1B IL6

Drugs & Therapeutics for Fallopian Tube Disease

Drugs for Fallopian Tube Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Povidone-iodine Approved 25655-41-8
2
Povidone Approved 9003-39-8 131751496
3
Scopolamine Approved, Investigational 51-34-3, 6533-68-2 5184
4
Iodine Approved, Investigational 7553-56-2 807
5
Paclitaxel Approved, Vet_approved 33069-62-4 36314
6
Carboplatin Approved 41575-94-4 10339178 498142 38904
7
Cadexomer iodine Experimental 94820-09-4
8 insulin
9 Insulin, Globin Zinc
10 Parasympatholytics
11 Calamus
12 Butylscopolammonium Bromide
13 Albumin-Bound Paclitaxel
14 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevalence of HbA1C in Different Categories of Obesity in Women With PCOS'A Propective Randomized Control Study Unknown status NCT01838122
2 Evaluation Of The Neural Therapy Effect On Long Term Postoperative Discomforts İn Patients Who Undergo Bilateral Tubal Ligation Completed NCT03891537
3 The Effect of Premedication Hyoscine-N-butylbromide Before Hysterosalpingography for Diagnosis of Proximal Tubal Obstruction in Infertile Women : A Randomized Double-Blind Controlled Trial Completed NCT02618785
4 Determinants of Age-Related Treatment Effectiveness in Ovarian Cancer: Prospective Study of Pharmacokinetics Patterns and Underlying Biology Active, not recruiting NCT02973750
5 Comparative Study of Hysteroscopic Versus Laparoscopic Tubal Occlusion in Cases of Communicating Hydrosalpinx and Planning for IVF Not yet recruiting NCT04037813

Search NIH Clinical Center for Fallopian Tube Disease

Cochrane evidence based reviews: fallopian tube diseases

Genetic Tests for Fallopian Tube Disease

Anatomical Context for Fallopian Tube Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Fallopian Tube Disease:

19
Fallopian Tube

MalaCards organs/tissues related to Fallopian Tube Disease:

40
Uterus, Ovary

Publications for Fallopian Tube Disease

Articles related to Fallopian Tube Disease:

(show all 25)
# Title Authors PMID Year
1
Study on the relationship between CXCR3 and its ligands and tubal tuberculosis. 61
33454369 2021
2
Management of Hydrosalpinx in the Era of Assisted Reproductive Technology: A Systematic Review and Meta-analysis. 61
32853797 2021
3
Outcomes of Minimally Invasive Management of Tubo-ovarian Abscess: A Systematic Review. 61
32992023 2021
4
Imaging Evaluation of Fallopian Tubes and Related Disease: A Primer for Radiologists. 61
32822282 2020
5
Guideline No. 403: Initial Investigation and Management of Adnexal Masses. 61
32736853 2020
6
Nonovarian Mimics of Ovarian Malignancy. 61
31375172 2019
7
[Management of fallopian tube diseases in reproductive women, to prevent spontaneous repture of the pregnant uterus]. 61
29747268 2018
8
Diagnostic and remedial capability of transcervical falloposcopy in conjunction with laparoscopy. 61
25200821 2014
9
[Fallopian tube disease on magnetic resonance imaging]. 61
23266314 2013
10
[Identification and analysis of a putative pathogenicity island Uu146-Uu170 in Ureaplasma urealyticum collected from sterile patients]. 61
23328422 2012
11
Primary culture and immortalization of human fallopian tube secretory epithelial cells. 61
22936217 2012
12
Fallopian tube disease in the nonpregnant patient. 61
21415195 2011
13
Discriminative MRI features of fallopian tube masses. 61
19589421 2009
14
Infertility. 61
17390595 2007
15
Experience of tubal surgery for infertility at the Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria. 61
15977444 2004
16
Fallopian tube disease: the cobblestone pattern as a radiographic sign. 61
11058655 2000
17
Falloposcopy--a prerequisite to the proper assessment of tubal infertility. 61
11821573 1999
18
Diagnostic and therapeutic value of nonhysteroscopic transvaginal falloposcopy with a linear everting catheter. 61
9884445 1998
19
Benign extraovarian mimics of ovarian cancer. Distinction with imaging studies. 61
9316756 1997
20
Fallopian tube disease: limited value of treatment with fallopian tube catheterization. 61
8259393 1994
21
Outpatient falloposcopy: intra-luminal imaging of the fallopian tube by trans-uterine fibre-optic endoscopy as an outpatient procedure. 61
1419994 1992
22
Benign disease of the uterus and ovaries. Applications of magnetic resonance imaging. 61
1631284 1992
23
Fluoroscopic transcervical fallopian tube catheterization for diagnosis and treatment of female infertility caused by tubal obstruction. 61
3175081 1988
24
Ovulation induction with low doses of clomiphene citrate. 61
3945466 1986
25
Obstetrics, Gynæcology, and Pædiatrics: Post-Mortem Delivery-Stypticin in Uterine Hæmorrhage-The Ultimate Fate of Placental Tissue Retained in Utero-Congenital Luxation of Knee-Extra Uterine Gestation-Antiseptic Performance of Embryotomy-Conservation of the Ovary in Hysterectomy and Hystero-Myomectomy-Conservative Surgery of Uterine Appendages-Conservative Treatment of Fallopian-Tube Disease. 61
29001737 1898

Variations for Fallopian Tube Disease

Expression for Fallopian Tube Disease

Search GEO for disease gene expression data for Fallopian Tube Disease.

Pathways for Fallopian Tube Disease

Pathways related to Fallopian Tube Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 TP53 TNF TLR4 SLPI SIGLEC5 IL6
2
Show member pathways
13.85 TP53 TNF IL6 IL1B CXCL8 CD4
3
Show member pathways
13.71 TP53 TNF TLR4 IL6 IL1B CXCL8
4
Show member pathways
13.43 TP53 TNF TLR4 IL6 IL1B CXCL8
5
Show member pathways
13.38 TP53 TNF IL6 IL1B CXCL8 CD4
6
Show member pathways
13.33 TNF IL6 IL1B CXCL8 CD4 CCR6
7
Show member pathways
12.9 TP53 TNF TLR4 IL6 IL1B CXCL8
8
Show member pathways
12.86 TP53 TNF TLR4 IL6 IL1B CXCL8
9
Show member pathways
12.77 TNF TLR4 IL6 IL1B CXCL8
10
Show member pathways
12.75 TNF TLR4 IL6 IL1B CXCL8
11
Show member pathways
12.69 TP53 TNF IL1B CD4 CCR5
12
Show member pathways
12.63 TNF TLR4 IL6 IL1B CD4
13
Show member pathways
12.62 TP53 TNF IL6 IL1B CD4
14
Show member pathways
12.62 TNF TLR4 IL6 IL1B CD4 CCR5
15 12.45 TP53 TNF TLR4 IL1B CXCL8
16
Show member pathways
12.38 TNF IL6 CXCL8 CCR6 CCR5
17 12.37 TP53 TNF IL6 CD4
18
Show member pathways
12.37 TP53 TNF MTRR IL6 IL1B
19
Show member pathways
12.36 TNF IL6 IL1B CXCL8
20
Show member pathways
12.33 TP53 TNF TLR4 IL6 IL1B CXCL8
21
Show member pathways
12.31 RAD51D RAD51C BRCA2 BRCA1
22
Show member pathways
12.3 TP53 TNF IL6 IL1B CXCL8
23
Show member pathways
12.29 TNF TLR4 IL6 CXCL8
24
Show member pathways
12.29 TNF TLR4 IL1B CCR5
25 12.27 TNF TLR4 IL6 IL1B CAMP
26 12.22 TP53 TNF TLR4 IL6
27 12.21 TNF IL6 IL1B CXCL8
28
Show member pathways
12.2 TNF TLR4 IL6 IL1B CXCL8
29 12.17 TNF TLR4 IL6 IL1B CXCL8 CAMP
30
Show member pathways
12.16 RAD51D RAD51C BRCA2 BRCA1
31 12.01 TNF IL6 CEACAM3 CEACAM1 CD4
32 12 TP53 IL6 IL1B CXCL8
33 11.99 TP53 TNF IL6 IL1B CXCL8
34 11.98 TNF TLR4 IL1B CXCL8
35 11.96 TNF IL6 IL1B CXCL8
36 11.95 TNF IL6 IL1B CD4
37 11.92 TNF TLR4 IL6 IL1B CXCL8
38
Show member pathways
11.91 TLR4 IL6 IL1B CD4
39 11.87 TNF TLR4 IL6 IL1B CXCL8 CD4
40 11.84 TNF IL1B CD4 CCR6
41 11.84 TNF TLR4 IL6 IL1B CXCL8
42 11.79 TNF IL6 IL1B CD4
43 11.73 TNF TLR4 IL6 CCR6
44
Show member pathways
11.7 TNF IL6 IL1B CXCL8
45 11.69 TNF IL6 IL1B CXCL8
46
Show member pathways
11.68 TNF TLR4 IL6 IL1B CD4
47 11.65 TNF TLR4 IL6 IL1B CXCL8
48 11.63 IL6 CXCL8 BRCA1
49 11.59 TP53 TNF IL6
50 11.58 TP53 IL6 CXCL8 BRCA1

GO Terms for Fallopian Tube Disease

Cellular components related to Fallopian Tube Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.65 TNF TLR4 CD4 CCR6 CCR5
2 cell surface GO:0009986 9.63 TNF TLR4 CEACAM1 CD4 CCR6 CCR5
3 Rad51B-Rad51C-Rad51D-XRCC2 complex GO:0033063 8.96 RAD51D RAD51C
4 replication fork GO:0005657 8.8 TP53 RAD51D RAD51C

Biological processes related to Fallopian Tube Disease according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 10.09 SLPI SIGLEC5 CEACAM3 CEACAM1 CAMP
2 positive regulation of transcription, DNA-templated GO:0045893 10.09 TP53 TNF IL6 IL1B CD4 BRCA2
3 inflammatory response GO:0006954 9.97 TNF TLR4 IL6 IL1B CXCL8 CCR5
4 positive regulation of protein phosphorylation GO:0001934 9.96 TNF IL1B CD4 CAMP
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.94 TNF TLR4 IL6 IL1B
6 positive regulation of angiogenesis GO:0045766 9.92 IL1B CXCL8 CAMP BRCA1
7 DNA recombination GO:0006310 9.88 RAD51D RAD51C BRCA2 BRCA1
8 positive regulation of gene expression GO:0010628 9.87 TP53 TNF TLR4 IL6 IL1B CXCL8
9 regulation of insulin secretion GO:0050796 9.86 TNF IL6 IL1B
10 chemokine-mediated signaling pathway GO:0070098 9.86 CXCL8 CCR6 CCR5
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR4 IL1B
12 positive regulation of interferon-gamma production GO:0032729 9.85 TNF TLR4 IL1B
13 double-strand break repair GO:0006302 9.84 TP53 BRCA2 BRCA1
14 positive regulation of T cell proliferation GO:0042102 9.84 IL6 IL1B CD4
15 positive regulation of interleukin-6 production GO:0032755 9.84 TNF TLR4 IL6 IL1B
16 humoral immune response GO:0006959 9.83 TNF IL6 CCR6
17 positive regulation of interleukin-1 beta production GO:0032731 9.83 TNF TLR4 IL6
18 defense response to Gram-negative bacterium GO:0050829 9.83 TLR4 IL6 CD4 CAMP
19 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.81 TNF BRCA2 BRCA1
20 double-strand break repair via homologous recombination GO:0000724 9.81 RAD51D RAD51C BRCA2 BRCA1
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 TNF TLR4 IL1B
22 positive regulation of chemokine production GO:0032722 9.79 TNF TLR4 IL6
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TNF TLR4 IL1B
24 chromosome organization GO:0051276 9.77 TP53 RAD51D BRCA2
25 positive regulation of vascular endothelial growth factor production GO:0010575 9.76 IL6 IL1B BRCA1
26 negative regulation of neurogenesis GO:0050768 9.74 TNF IL6 IL1B
27 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.73 TNF TLR4 IL6
28 positive regulation of interleukin-8 production GO:0032757 9.73 TNF TLR4 IL6 IL1B
29 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.7 TNF TLR4
30 cytokine-mediated signaling pathway GO:0019221 9.7 TP53 TNF IL6 IL1B CXCL8 CD4
31 regulation of establishment of endothelial barrier GO:1903140 9.69 TNF IL1B
32 response to salt stress GO:0009651 9.69 TP53 TNF
33 negative regulation of lipid storage GO:0010888 9.68 TNF IL6
34 fusion of virus membrane with host plasma membrane GO:0019064 9.67 CD4 CCR5
35 chordate embryonic development GO:0043009 9.65 BRCA2 BRCA1
36 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL6 IL1B
37 positive regulation of fever generation GO:0031622 9.64 TNF IL1B
38 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.63 TP53 BRCA2 BRCA1
39 sequestering of triglyceride GO:0030730 9.62 TNF IL1B
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 TNF IL1B
41 immune response GO:0006955 9.61 TNF TLR4 SLPI IL6 IL1B CXCL8
42 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6 IL1B
43 telomere maintenance via recombination GO:0000722 9.54 RAD51D RAD51C BRCA2
44 vascular endothelial growth factor production GO:0010573 9.43 TNF IL6 IL1B
45 cellular response to lipopolysaccharide GO:0071222 9.17 TNF TLR4 IL6 IL1B CXCL8 CCR5

Molecular functions related to Fallopian Tube Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL6 IL1B CXCL8
2 identical protein binding GO:0042802 9.23 TP53 TNF TLR4 CEACAM1 CD4 CCR5

Sources for Fallopian Tube Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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