MCID: FLL003
MIFTS: 32

Fallopian Tube Endometrioid Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Fallopian Tube Endometrioid Adenocarcinoma

MalaCards integrated aliases for Fallopian Tube Endometrioid Adenocarcinoma:

Name: Fallopian Tube Endometrioid Adenocarcinoma 12 15 70
Endometrioid Carcinoma of the Fallopian Tube 12
Fallopian Tube Endometrioid Neoplasm 12
Fallopian Tube Endometrioid Cancer 12
Fallopian Tube Endometrioid Tumor 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5831
NCIt 50 C40111 C6279
UMLS 70 C1333592 C1517113

Summaries for Fallopian Tube Endometrioid Adenocarcinoma

Disease Ontology : 12 A fallopian tube adenocarcinoma that derives from endometrial epithelial cells of glandular origin.

MalaCards based summary : Fallopian Tube Endometrioid Adenocarcinoma, also known as endometrioid carcinoma of the fallopian tube, is related to fallopian tube carcinoma and serous cystadenocarcinoma. An important gene associated with Fallopian Tube Endometrioid Adenocarcinoma is CALB2 (Calbindin 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Paclitaxel and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include endothelial, and related phenotypes are cellular and embryo

Related Diseases for Fallopian Tube Endometrioid Adenocarcinoma

Diseases related to Fallopian Tube Endometrioid Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 fallopian tube carcinoma 30.3 RAD51C PAX8 ERBB2
2 serous cystadenocarcinoma 29.9 PAX8 MUC16 ERBB2 ARID1A
3 female reproductive endometrioid cancer 29.0 PMS2 PAX8 MSH6 ERBB2 ARID1A
4 cervical carcinosarcoma 10.4 MME CALB2
5 pacinian tumor 10.4 MME CALB2
6 malignant glandular tumor of peripheral nerve sheath 10.4 MYOG CALB2
7 lung combined type small cell carcinoma 10.4 MYOG MME
8 heart lymphoma 10.4 MYOG MME
9 pseudo-meigs syndrome 10.4 MUC16 CALB2
10 cervical polyp 10.4 MYOG MME
11 myoblastoma 10.4 MYOG CALB2
12 pancreatic mucinous cystadenoma 10.4 MME CALB2
13 ovarian endometrioid stromal sarcoma 10.4 MME CALB2
14 endometriosis 10.4
15 early invasive cervical adenocarcinoma 10.4 INSM1 CDKN2A
16 inflammatory liposarcoma 10.4 MME CDKN2A
17 lymphohistiocytoid mesothelioma 10.4 CDKN2A CALB2
18 cervix endometriosis 10.4 PAX2 MME
19 vagina sarcoma 10.4 MYOG MME
20 papillary squamous carcinoma 10.3 INSM1 CDKN2A
21 lung leiomyosarcoma 10.3 MYOG CALB2
22 ovarian sex-cord stromal tumor 10.3 MME CALB2
23 atypical polypoid adenomyoma 10.3 MME CDKN2A
24 adenomyoma 10.3 MME CDKN2A
25 adult malignant schwannoma 10.3 MYOG CDKN2A
26 nasal cavity lymphoma 10.3 MME CDKN2A
27 cellular leiomyoma 10.3 MUC16 MME
28 pericardial mesothelioma 10.3 MUC16 CALB2
29 parotid gland adenoid cystic carcinoma 10.3 ERBB2 CDKN2A
30 breast metaplastic carcinoma 10.3 MME ERBB2
31 vulva basal cell carcinoma 10.3 ERBB2 CDKN2A
32 hemometra 10.3 PTPRN INSM1
33 isthmus cancer 10.3 PTPRN INSM1
34 breast malignant phyllodes tumor 10.3 MME ERBB2
35 ovary sarcoma 10.3 MME CALB2
36 microinvasive cervical squamous cell carcinoma 10.3 PTPRN INSM1
37 reproductive organ benign neoplasm 10.3 MME CDKN2A CALB2
38 heart cancer 10.3 MYOG CALB2
39 lymphocele 10.3 PTPRN INSM1
40 bleeding disorder, platelet-type, 17 10.3 PTPRN INSM1
41 malignant spiradenoma 10.3 CDKN2A CALB2
42 cystadenoma 10.3 MUC16 MME CALB2
43 vaginal cancer 10.3 MME INSM1 CDKN2A
44 epididymal neoplasm 10.3 PAX2 MME CALB2
45 kidney cortex disease 10.3 MYOG MME
46 localized osteosarcoma 10.3 ERBB2 CDKN2A
47 ovarian mesodermal adenosarcoma 10.2 PAX8 MYOG
48 rete testis neoplasm 10.2 PAX8 CALB2
49 liposarcoma 10.2 MYOG CDKN2A CALB2
50 bowenoid papulosis 10.2 CDKN2A CCNE1

Graphical network of the top 20 diseases related to Fallopian Tube Endometrioid Adenocarcinoma:



Diseases related to Fallopian Tube Endometrioid Adenocarcinoma

Symptoms & Phenotypes for Fallopian Tube Endometrioid Adenocarcinoma

MGI Mouse Phenotypes related to Fallopian Tube Endometrioid Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 ARID1A CCNE1 CDKN2A ERBB2 HNF1B INSM1
2 embryo MP:0005380 9.91 ARID1A CCNE1 CDKN2A ERBB2 HNF1B MYOG
3 endocrine/exocrine gland MP:0005379 9.9 ARID1A CCNE1 CDKN2A ERBB2 HNF1B INSM1
4 mortality/aging MP:0010768 9.73 ARID1A CCNE1 CDKN2A ERBB2 HNF1B INSM1
5 neoplasm MP:0002006 9.1 ARID1A CCNE1 CDKN2A ERBB2 MSH6 PMS2

Drugs & Therapeutics for Fallopian Tube Endometrioid Adenocarcinoma

Drugs for Fallopian Tube Endometrioid Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
2
Bevacizumab Approved, Investigational Phase 3 216974-75-3
3
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
4 Angiogenesis Inhibitors Phase 3
5 Tubulin Modulators Phase 3
6 Immunoglobulin G Phase 3
7 Antimitotic Agents Phase 3
8 Mitogens Phase 3
9 Immunoglobulins, Intravenous Phase 3
10 Albumin-Bound Paclitaxel Phase 3
11 Immunologic Factors Phase 3
12 Endothelial Growth Factors Phase 3
13
Olaparib Approved Phase 2 763113-22-0 23725625
14
Ipilimumab Approved Phase 2 477202-00-9
15
Cediranib Investigational Phase 2 288383-20-0 9933475
16
Maleic acid Experimental Phase 2 110-16-7 444266
17
Tremelimumab Investigational Phase 2 745013-59-6
18 Maytansine Phase 2
19 Protein Kinase Inhibitors Phase 2
20 Antineoplastic Agents, Immunological Phase 2
21 Antibodies Phase 2
22 Immunoglobulins Phase 2
23 Antibodies, Monoclonal Phase 2
24 Poly(ADP-ribose) Polymerase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 GOG-0262: A Phase III Trial of Every-3-Weeks Paclitaxel Versus Dose Dense Weekly Paclitaxel in Combination With Carboplatin With or Without Concurrent and Consolidation Bevacizumab (NSC #704865) in the Treatment of Primary Stage II, III or IV Epithelial Ovarian, Peritoneal or Fallopian Tube Cancer and ACRIN 6695: Perfusion CT Imaging to Evaluate Treatment Response in Patients Participating in GOG-0262 Active, not recruiting NCT01167712 Phase 3 Carboplatin;Paclitaxel
2 Life on the Go 2: Evaluating the Effect of Physical Activity of Patients With Recurrent Ovarian Cancer Using State of the Art Activity Tracking Device Completed NCT03685695 Phase 2
3 A Randomized Phase 2 Study of Bevacizumab and Either Weekly Anetumab Ravtansine or Weekly Paclitaxel in Platinum-Resistant or Platinum Refractory Ovarian Cancer Recruiting NCT03587311 Phase 2 Paclitaxel
4 A Phase 2 Study of Olaparib and Cediranib for the Treatment of Recurrent Ovarian Cancer Active, not recruiting NCT02345265 Phase 2 Cediranib Maleate;Olaparib
5 A Phase II Randomized Trial of Olaparib Versus Olaparib Plus Tremelimumab in Platinum-Sensitive Recurrent Ovarian Cancer Suspended NCT04034927 Phase 2 Olaparib

Search NIH Clinical Center for Fallopian Tube Endometrioid Adenocarcinoma

Genetic Tests for Fallopian Tube Endometrioid Adenocarcinoma

Anatomical Context for Fallopian Tube Endometrioid Adenocarcinoma

MalaCards organs/tissues related to Fallopian Tube Endometrioid Adenocarcinoma:

40
Endothelial

Publications for Fallopian Tube Endometrioid Adenocarcinoma

Articles related to Fallopian Tube Endometrioid Adenocarcinoma:

# Title Authors PMID Year
1
Primary fallopian tube carcinoma associated with ovulation induction; a case report. 61
18217974 2008

Variations for Fallopian Tube Endometrioid Adenocarcinoma

Expression for Fallopian Tube Endometrioid Adenocarcinoma

Search GEO for disease gene expression data for Fallopian Tube Endometrioid Adenocarcinoma.

Pathways for Fallopian Tube Endometrioid Adenocarcinoma

Pathways related to Fallopian Tube Endometrioid Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.4 PAX8 MSH6 ERBB2 CDKN2A CCNE1
2 12.28 PAX8 MSH6 ERBB2 CDKN2A CCNE1
3 11 MSH6 ERBB2 CDKN2A
4 10 PAX8 PAX2 CCNE1

GO Terms for Fallopian Tube Endometrioid Adenocarcinoma

Cellular components related to Fallopian Tube Endometrioid Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.73 RAD51C PMS2 PAX8 PAX2 MYOG MSH6
2 nucleus GO:0005634 9.5 RAD51C PTPRN PMS2 PAX8 PAX2 MYOG
3 mismatch repair complex GO:0032300 9.16 PMS2 MSH6

Biological processes related to Fallopian Tube Endometrioid Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 PTPRN PAX8 PAX2 MYOG HNF1B CDKN2A
2 positive regulation of transcription, DNA-templated GO:0045893 9.99 PAX8 PAX2 MYOG HNF1B CDKN2A ARID1A
3 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.61 PAX8 PAX2
4 positive regulation of cell cycle arrest GO:0071158 9.61 MYOG INSM1 CDKN2A
5 replicative senescence GO:0090399 9.59 MME CDKN2A
6 urogenital system development GO:0001655 9.58 PAX8 PAX2
7 somatic hypermutation of immunoglobulin genes GO:0016446 9.58 PMS2 MSH6
8 mesonephros development GO:0001823 9.57 PAX8 PAX2
9 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.56 PAX8 PAX2
10 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.55 PAX8 PAX2
11 metanephric epithelium development GO:0072207 9.54 PAX8 PAX2
12 negative regulation of immature T cell proliferation in thymus GO:0033088 9.52 ERBB2 CDKN2A
13 metanephric nephron tubule formation GO:0072289 9.49 PAX8 PAX2
14 metanephric distal convoluted tubule development GO:0072221 9.48 PAX8 PAX2
15 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.46 PAX8 PAX2
16 positive regulation of metanephric DCT cell differentiation GO:2000594 9.4 PAX8 PAX2
17 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.37 PAX8 PAX2
18 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.32 PAX8 PAX2
19 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.26 PAX8 PAX2
20 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX8 PAX2
21 pronephric field specification GO:0039003 8.96 PAX8 PAX2
22 pronephros development GO:0048793 8.8 PAX8 PAX2 HNF1B

Molecular functions related to Fallopian Tube Endometrioid Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.72 PAX8 PAX2 MYOG INSM1 HNF1B
2 DNA binding GO:0003677 9.32 RAD51C PMS2 PAX8 PAX2 MYOG MSH6
3 four-way junction DNA binding GO:0000400 9.26 RAD51C MSH6
4 mismatched DNA binding GO:0030983 9.16 PMS2 MSH6
5 proximal promoter sequence-specific DNA binding GO:0000987 9.13 PAX2 MYOG HNF1B

Sources for Fallopian Tube Endometrioid Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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