MCID: FLL015
MIFTS: 31

Fallopian Tube Serous Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Fallopian Tube Serous Adenocarcinoma

MalaCards integrated aliases for Fallopian Tube Serous Adenocarcinoma:

Name: Fallopian Tube Serous Adenocarcinoma 12 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5598
NCIt 49 C40099
UMLS 71 C1517124

Summaries for Fallopian Tube Serous Adenocarcinoma

Disease Ontology : 12 A fallopian tube adenocarcinoma that derives from epithelial cells originating in glandular tissue forming serous lesions.

MalaCards based summary : Fallopian Tube Serous Adenocarcinoma is related to fallopian tube adenocarcinoma and adenocarcinoma. An important gene associated with Fallopian Tube Serous Adenocarcinoma is FZD3 (Frizzled Class Receptor 3), and among its related pathways/superpathways are CDK-mediated phosphorylation and removal of Cdc6 and ERK Signaling. The drugs Olaparib and Poly(ADP-ribose) Polymerase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include breast, and related phenotypes are cardiovascular system and embryo

Related Diseases for Fallopian Tube Serous Adenocarcinoma

Graphical network of the top 20 diseases related to Fallopian Tube Serous Adenocarcinoma:



Diseases related to Fallopian Tube Serous Adenocarcinoma

Symptoms & Phenotypes for Fallopian Tube Serous Adenocarcinoma

MGI Mouse Phenotypes related to Fallopian Tube Serous Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 EPO FZD1 NIPBL ROR2 TNFRSF1B WNT11
2 embryo MP:0005380 9.87 EPO FZD1 FZD3 NIPBL RHOA ROR2
3 craniofacial MP:0005382 9.85 FZD1 NIPBL ROR2 TNFRSF1B WNT11 WNT5A
4 hearing/vestibular/ear MP:0005377 9.65 FZD1 FZD3 NIPBL ROR2 WNT5A
5 limbs/digits/tail MP:0005371 9.63 EPO FZD3 NIPBL ROR2 WNT5A WNT5B
6 nervous system MP:0003631 9.56 FZD1 FZD3 NIPBL RHOA ROR2 TNFRSF1B
7 normal MP:0002873 9.23 EPO FZD1 FZD10 FZD3 NIPBL RHOA

Drugs & Therapeutics for Fallopian Tube Serous Adenocarcinoma

Drugs for Fallopian Tube Serous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Olaparib Approved Phase 1 763113-22-0 23725625
2 Poly(ADP-ribose) Polymerase Inhibitors Phase 1
3
Talazoparib Approved, Investigational Early Phase 1 1207456-01-6 135565082

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I/II, Single Center, Proof-of-Concept Study of Birinapant in Combination With Platinum Based Chemotherapy Targeting Recurrent High Grade Serous Ovarian Carcinomas (HGSOC) Withdrawn NCT02756130 Phase 1, Phase 2 Birinapant;Carboplatin
2 A Phase 1 Study of PARP Inhibitor Olaparib and HSP90 Inhibitor AT13387 for Treatment of Advanced Solid Tumors With Expansion in Patients With Recurrent Epithelial Ovarian, Fallopian Tube, Peritoneal Cancer or Recurrent Triple-Negative Breast Cancer Active, not recruiting NCT02898207 Phase 1 Olaparib;Onalespib
3 POSITION: A Pilot Study of Induction PARP Inhibition in Ovarian Cancer Active, not recruiting NCT02316834 Early Phase 1 BMN 673

Search NIH Clinical Center for Fallopian Tube Serous Adenocarcinoma

Genetic Tests for Fallopian Tube Serous Adenocarcinoma

Anatomical Context for Fallopian Tube Serous Adenocarcinoma

MalaCards organs/tissues related to Fallopian Tube Serous Adenocarcinoma:

40
Breast

Publications for Fallopian Tube Serous Adenocarcinoma

Articles related to Fallopian Tube Serous Adenocarcinoma:

# Title Authors PMID Year
1
Fallopian tube serous adenocarcinoma with dizziness as the initial symptom: a case report. 61
31500488 2019
2
Spinal Metastases from a Primary Fallopian Tube Serous Adenocarcinoma: A Case Report. 61
26430604 2015
3
Proteomic analyses of serous and endometrioid epithelial ovarian cancers - cases studies - molecular insights of a possible histological etiology of serous ovarian cancer. 61
23589350 2013
4
Left fallopian tube primitive serous adenocarcinoma presenting as a cardiac tamponade - a case report and review of literature. 61
23967559 2013

Variations for Fallopian Tube Serous Adenocarcinoma

Expression for Fallopian Tube Serous Adenocarcinoma

Search GEO for disease gene expression data for Fallopian Tube Serous Adenocarcinoma.

Pathways for Fallopian Tube Serous Adenocarcinoma

Pathways related to Fallopian Tube Serous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.15 WNT5B WNT5A WNT11 TNFRSF1B ROR2 RHOA
2
Show member pathways
13.66 WNT5A TNFRSF1B ROR2 RHOA FZD3 FZD10
3
Show member pathways
13.22 WNT5B WNT5A WNT11 ROR2 FZD3 FZD10
4
Show member pathways
12.95 WNT5B WNT5A WNT11 FZD3 FZD10 FZD1
5
Show member pathways
12.85 WNT5B WNT5A WNT11 ROR2 RHOA FZD3
6
Show member pathways
12.84 WNT5B WNT5A WNT11 FZD3 FZD10 FZD1
7
Show member pathways
12.73 WNT5B WNT5A WNT11 FZD3 FZD10 FZD1
8 12.73 WNT5B WNT5A WNT11 RHOA FZD3 FZD10
9
Show member pathways
12.46 WNT5B WNT5A WNT11 FZD3 FZD10 FZD1
10
Show member pathways
12.39 WNT5A WNT11 FZD3 FZD10 FZD1
11
Show member pathways
12.35 WNT5B WNT5A WNT11 ROR2 RHOA FZD3
12 12.31 WNT5B WNT5A WNT11 RHOA FZD3 FZD10
13
Show member pathways
12.22 WNT5B WNT5A WNT11 TNFRSF1B RHOA FZD3
14 12.19 WNT5B WNT5A RHOA FZD3
15 12.19 WNT5B WNT5A WNT11 FZD3 FZD10 FZD1
16 12.18 WNT5B WNT5A WNT11 RHOA FZD3 FZD10
17 12.14 WNT5B WNT5A WNT11 FZD3 FZD10 FZD1
18 12.11 WNT5B WNT5A FZD3 FZD10 FZD1
19
Show member pathways
12.1 WNT5B WNT5A WNT11 FZD3 FZD10 FZD1
20 12.06 WNT5B WNT5A WNT11 FZD3 FZD10 FZD1
21
Show member pathways
12.02 WNT5A RHOA FZD1
22 12.01 RHOA FZD3 FZD10 FZD1
23 11.97 WNT5B WNT5A WNT11 RHOA
24 11.95 RHOA FZD3 FZD10 FZD1
25 11.82 FZD3 FZD10 FZD1
26 11.74 WNT11 RHOA FZD3 FZD10 FZD1
27
Show member pathways
11.62 WNT5B WNT5A WNT11 FZD1
28
Show member pathways
11.48 WNT5B WNT5A WNT11 ROR2 RHOA FZD3
29 11.28 WNT5A ROR2 RHOA
30 11.27 WNT5A ROR2 FZD10 FZD1
31 11.21 WNT5B WNT5A WNT11 RHOA FZD10 FZD1

GO Terms for Fallopian Tube Serous Adenocarcinoma

Cellular components related to Fallopian Tube Serous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 WNT5B WNT5A TNFRSF1B ROR2 RHOA FZD3
2 axon GO:0030424 9.26 TNFRSF1B ROR2 RHOA FZD3
3 cell surface GO:0009986 9.17 WNT5B WNT5A ROR2 FZD3 FZD10 FZD1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 WNT5A ROR2

Biological processes related to Fallopian Tube Serous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10.08 WNT5A WNT11 ROR2 RHOA APOLD1
2 positive regulation of transcription, DNA-templated GO:0045893 10.04 WNT5A WNT11 ROR2 FZD1 EPO
3 multicellular organism development GO:0007275 10.02 WNT5B WNT5A WNT11 ROR2 NIPBL FZD3
4 negative regulation of transcription, DNA-templated GO:0045892 9.99 WNT5A WNT11 NIPBL FZD1
5 positive regulation of cell migration GO:0030335 9.93 WNT5B WNT11 ROR2 RHOA
6 cell surface receptor signaling pathway GO:0007166 9.92 TNFRSF1B FZD3 FZD10 FZD1
7 cellular response to lipopolysaccharide GO:0071222 9.86 WNT5A TNFRSF1B RHOA
8 response to hypoxia GO:0001666 9.85 RHOA EPO APOLD1
9 negative regulation of canonical Wnt signaling pathway GO:0090090 9.83 WNT5B WNT5A WNT11 ROR2 FZD1
10 negative regulation of cell death GO:0060548 9.81 WNT11 TNFRSF1B RHOA
11 positive regulation of neuron projection development GO:0010976 9.8 WNT5A ROR2 FZD1 EPO
12 inner ear morphogenesis GO:0042472 9.79 WNT5A ROR2 FZD3
13 cellular response to retinoic acid GO:0071300 9.78 WNT5B WNT5A WNT11 FZD10
14 cell fate commitment GO:0045165 9.76 WNT5B WNT5A WNT11 ROR2
15 neuron differentiation GO:0030182 9.73 WNT5B WNT5A WNT11 FZD3 FZD10 FZD1
16 outflow tract morphogenesis GO:0003151 9.72 WNT11 NIPBL FZD1
17 canonical Wnt signaling pathway GO:0060070 9.72 WNT5A WNT11 FZD3 FZD10 FZD1
18 Wnt signaling pathway, calcium modulating pathway GO:0007223 9.71 WNT5A WNT11 ROR2 FZD3
19 ventricular septum morphogenesis GO:0060412 9.7 WNT11 FZD1
20 positive regulation of JUN kinase activity GO:0043507 9.7 WNT5A ROR2 FZD10
21 Wnt signaling pathway GO:0016055 9.7 WNT5B WNT5A WNT11 ROR2 FZD3 FZD10
22 negative chemotaxis GO:0050919 9.69 WNT5A RHOA
23 midbrain development GO:0030901 9.69 WNT5A FZD3
24 response to electrical stimulus GO:0051602 9.68 FZD3 EPO
25 post-anal tail morphogenesis GO:0036342 9.67 WNT5A FZD3
26 somite development GO:0061053 9.67 WNT5A WNT11
27 establishment of epithelial cell apical/basal polarity GO:0045198 9.67 WNT5A RHOA
28 positive regulation of ossification GO:0045778 9.66 WNT5A NIPBL
29 establishment of planar polarity GO:0001736 9.66 WNT5A FZD3
30 presynapse assembly GO:0099054 9.65 WNT5A FZD1
31 secondary palate development GO:0062009 9.65 WNT5A WNT11
32 planar cell polarity pathway involved in neural tube closure GO:0090179 9.65 WNT5A FZD1
33 positive regulation of protein kinase C signaling GO:0090037 9.64 WNT5A WNT11
34 paraxial mesoderm formation GO:0048341 9.62 WNT5A WNT11
35 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1904953 9.61 WNT5A FZD1
36 positive regulation of protein kinase C activity GO:1900020 9.6 WNT5A ROR2
37 negative regulation of mesenchymal cell proliferation GO:0072201 9.59 WNT5A WNT11
38 planar cell polarity pathway involved in axon guidance GO:1904938 9.58 WNT5A FZD3
39 convergent extension involved in axis elongation GO:0060028 9.58 WNT5A WNT11
40 notochord morphogenesis GO:0048570 9.57 WNT5A WNT11
41 non-canonical Wnt signaling pathway via JNK cascade GO:0038031 9.56 WNT5A FZD10
42 planar cell polarity pathway involved in axis elongation GO:0003402 9.54 WNT5A WNT11
43 planar cell polarity pathway involved in gastrula mediolateral intercalation GO:0060775 9.51 WNT5A WNT11
44 Wnt signaling pathway, planar cell polarity pathway GO:0060071 9.43 WNT5A WNT11 ROR2 RHOA FZD3 FZD1
45 non-canonical Wnt signaling pathway GO:0035567 9.02 WNT5A WNT11 FZD3 FZD10 FZD1

Molecular functions related to Fallopian Tube Serous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.56 WNT5B WNT5A WNT11 FZD1
2 Wnt-activated receptor activity GO:0042813 9.33 FZD3 FZD10 FZD1
3 protein kinase activator activity GO:0030295 9.32 WNT11 EPO
4 Wnt-protein binding GO:0017147 9.26 ROR2 FZD3 FZD10 FZD1
5 frizzled binding GO:0005109 9.02 WNT5B WNT5A WNT11 ROR2 FZD1

Sources for Fallopian Tube Serous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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