MCID: FLL015
MIFTS: 31

Fallopian Tube Serous Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Fallopian Tube Serous Adenocarcinoma

MalaCards integrated aliases for Fallopian Tube Serous Adenocarcinoma:

Name: Fallopian Tube Serous Adenocarcinoma 12 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5598
NCIt 49 C40099
UMLS 71 C1517124

Summaries for Fallopian Tube Serous Adenocarcinoma

Disease Ontology : 12 A fallopian tube adenocarcinoma that derives from epithelial cells originating in glandular tissue forming serous lesions.

MalaCards based summary : Fallopian Tube Serous Adenocarcinoma is related to fallopian tube adenocarcinoma and serous cystadenocarcinoma. An important gene associated with Fallopian Tube Serous Adenocarcinoma is FZD3 (Frizzled Class Receptor 3), and among its related pathways/superpathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Signaling by GPCR. The drugs Olaparib and Poly(ADP-ribose) Polymerase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include breast, and related phenotypes are cardiovascular system and craniofacial

Related Diseases for Fallopian Tube Serous Adenocarcinoma

Graphical network of the top 20 diseases related to Fallopian Tube Serous Adenocarcinoma:



Diseases related to Fallopian Tube Serous Adenocarcinoma

Symptoms & Phenotypes for Fallopian Tube Serous Adenocarcinoma

MGI Mouse Phenotypes related to Fallopian Tube Serous Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 FZD1 GSK3B NIPBL ROR2 WNT11 WNT5A
2 craniofacial MP:0005382 9.8 FZD1 GSK3B NIPBL ROR2 WNT11 WNT5A
3 hearing/vestibular/ear MP:0005377 9.65 FZD1 FZD3 NIPBL ROR2 WNT5A
4 nervous system MP:0003631 9.56 FZD1 FZD3 GSK3B NIPBL RHOA ROR2
5 limbs/digits/tail MP:0005371 9.55 FZD3 NIPBL ROR2 WNT5A WNT5B
6 normal MP:0002873 9.17 FZD1 FZD10 FZD3 GSK3B NIPBL RHOA

Drugs & Therapeutics for Fallopian Tube Serous Adenocarcinoma

Drugs for Fallopian Tube Serous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Olaparib Approved Phase 1 763113-22-0 23725625
2 Poly(ADP-ribose) Polymerase Inhibitors Phase 1
3
Talazoparib Approved, Investigational Early Phase 1 1207456-01-6 135565082

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I/II, Single Center, Proof-of-Concept Study of Birinapant in Combination With Platinum Based Chemotherapy Targeting Recurrent High Grade Serous Ovarian Carcinomas (HGSOC) Withdrawn NCT02756130 Phase 1, Phase 2 Birinapant;Carboplatin
2 A Phase 1 Study of PARP Inhibitor Olaparib and HSP90 Inhibitor AT13387 for Treatment of Advanced Solid Tumors With Expansion in Patients With Recurrent Epithelial Ovarian, Fallopian Tube, Peritoneal Cancer or Recurrent Triple-Negative Breast Cancer Active, not recruiting NCT02898207 Phase 1 Olaparib;Onalespib
3 POSITION: A Pilot Study of Induction PARP Inhibition in Ovarian Cancer Active, not recruiting NCT02316834 Early Phase 1 BMN 673

Search NIH Clinical Center for Fallopian Tube Serous Adenocarcinoma

Genetic Tests for Fallopian Tube Serous Adenocarcinoma

Anatomical Context for Fallopian Tube Serous Adenocarcinoma

MalaCards organs/tissues related to Fallopian Tube Serous Adenocarcinoma:

40
Breast

Publications for Fallopian Tube Serous Adenocarcinoma

Articles related to Fallopian Tube Serous Adenocarcinoma:

# Title Authors PMID Year
1
Fallopian tube serous adenocarcinoma with dizziness as the initial symptom: a case report. 61
31500488 2019
2
Spinal Metastases from a Primary Fallopian Tube Serous Adenocarcinoma: A Case Report. 61
26430604 2015
3
Proteomic analyses of serous and endometrioid epithelial ovarian cancers - cases studies - molecular insights of a possible histological etiology of serous ovarian cancer. 61
23589350 2013
4
Left fallopian tube primitive serous adenocarcinoma presenting as a cardiac tamponade - a case report and review of literature. 61
23967559 2013

Variations for Fallopian Tube Serous Adenocarcinoma

Expression for Fallopian Tube Serous Adenocarcinoma

Search GEO for disease gene expression data for Fallopian Tube Serous Adenocarcinoma.

Pathways for Fallopian Tube Serous Adenocarcinoma

Pathways related to Fallopian Tube Serous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 WNT5B WNT5A WNT11 ROR2 RHOA GSK3B
2
Show member pathways
14.01 WNT5B WNT5A WNT11 ROR2 RHOA GSK3B
3
Show member pathways
13.67 WNT5A ROR2 RHOA GSK3B FZD3 FZD10
4
Show member pathways
13.26 WNT5B WNT5A WNT11 ROR2 GSK3B FZD3
5
Show member pathways
13.14 WNT5B WNT5A WNT11 GSK3B FZD3 FZD10
6
Show member pathways
13 WNT5B WNT5A WNT11 GSK3B FZD3 FZD10
7
Show member pathways
12.92 WNT5B WNT5A WNT11 GSK3B FZD3 FZD10
8
Show member pathways
12.91 WNT5B WNT5A WNT11 ROR2 RHOA GSK3B
9 12.85 WNT5B WNT5A WNT11 RHOA GSK3B FZD3
10
Show member pathways
12.78 WNT5B WNT5A WNT11 GSK3B FZD3 FZD10
11
Show member pathways
12.73 RHOA GSK3B FZD10 FZD1
12
Show member pathways
12.5 WNT5B WNT5A WNT11 GSK3B FZD3 FZD10
13
Show member pathways
12.44 WNT5B WNT5A WNT11 RHOA GSK3B FZD3
14
Show member pathways
12.43 WNT5A WNT11 FZD3 FZD10 FZD1
15
Show member pathways
12.36 WNT5B WNT5A WNT11 GSK3B FZD3 FZD10
16 12.33 WNT5B WNT5A WNT11 RHOA FZD3 FZD10
17 12.28 WNT5B WNT5A RHOA GSK3B FZD3
18 12.26 WNT5B WNT5A WNT11 RHOA GSK3B FZD3
19 12.22 WNT5B WNT5A WNT11 GSK3B FZD3 FZD10
20 12.17 WNT5B WNT5A GSK3B FZD3 FZD10 FZD1
21
Show member pathways
12.15 WNT5A RHOA GSK3B FZD1
22 12.14 WNT5B WNT5A WNT11 GSK3B FZD3 FZD10
23 12.1 WNT5B WNT5A GSK3B
24 12.09 RHOA GSK3B FZD3 FZD10 FZD1
25 12.05 WNT5B WNT5A WNT11 RHOA GSK3B
26
Show member pathways
12.05 WNT5B WNT5A WNT11 ROR2 RHOA GSK3B
27 12.03 RHOA GSK3B FZD3 FZD10 FZD1
28 12.02 WNT5B WNT5A WNT11 GSK3B FZD3 FZD10
29 11.95 GSK3B FZD3 FZD10 FZD1
30 11.74 WNT11 RHOA GSK3B FZD3 FZD10 FZD1
31
Show member pathways
11.7 WNT5B WNT5A WNT11 GSK3B FZD1
32 11.65 WNT5B WNT5A WNT11 ROR2 RHOA FZD10
33 11.55 ROR2 RHOA GSK3B
34
Show member pathways
11.53 WNT5B WNT5A WNT11 ROR2 RHOA GSK3B
35 11.32 WNT5A ROR2 FZD10 FZD1
36 11.29 WNT5A ROR2 RHOA
37 10.91 GSK3B FZD1

GO Terms for Fallopian Tube Serous Adenocarcinoma

Cellular components related to Fallopian Tube Serous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.02 WNT5B WNT5A ROR2 RHOA GSK3B FZD3
2 dendrite GO:0030425 9.62 ROR2 RHOA GSK3B FZD3
3 axon GO:0030424 9.56 ROR2 RHOA GSK3B FZD3
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.4 WNT5A ROR2
5 postsynapse GO:0098794 9.33 WNT5A RHOA GSK3B
6 cell surface GO:0009986 9.17 WNT5B WNT5A ROR2 FZD3 FZD10 FZD1
7 Wnt signalosome GO:1990909 8.96 GSK3B FZD1

Biological processes related to Fallopian Tube Serous Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10.09 WNT5A WNT11 ROR2 RHOA GSK3B
2 multicellular organism development GO:0007275 10.06 WNT5B WNT5A WNT11 ROR2 NIPBL GSK3B
3 positive regulation of transcription, DNA-templated GO:0045893 10.01 WNT5A WNT11 ROR2 FZD1
4 protein phosphorylation GO:0006468 10.01 WNT5A WNT11 ROR2 GSK3B
5 negative regulation of transcription, DNA-templated GO:0045892 10 WNT5A WNT11 NIPBL FZD1
6 negative regulation of apoptotic process GO:0043066 9.99 WNT5A WNT11 GSK3B CEACAM5
7 positive regulation of GTPase activity GO:0043547 9.95 WNT5A WNT11 GSK3B FZD10
8 positive regulation of cell migration GO:0030335 9.92 WNT5B WNT11 ROR2 RHOA
9 positive regulation of neuron projection development GO:0010976 9.85 WNT5A ROR2 FZD1
10 negative regulation of canonical Wnt signaling pathway GO:0090090 9.85 WNT5B WNT5A WNT11 ROR2 GSK3B FZD1
11 neuron differentiation GO:0030182 9.8 WNT5B WNT5A WNT11 FZD3 FZD10 FZD1
12 inner ear morphogenesis GO:0042472 9.78 WNT5A ROR2 FZD3
13 cellular response to retinoic acid GO:0071300 9.78 WNT5B WNT5A WNT11 FZD10
14 cell fate commitment GO:0045165 9.76 WNT5B WNT5A WNT11 ROR2
15 outflow tract morphogenesis GO:0003151 9.74 WNT11 NIPBL FZD1
16 Wnt signaling pathway, calcium modulating pathway GO:0007223 9.73 WNT5A WNT11 ROR2 FZD3
17 Wnt signaling pathway, planar cell polarity pathway GO:0060071 9.73 WNT5A WNT11 ROR2 RHOA FZD3 FZD1
18 regulation of neuron projection development GO:0010975 9.71 RHOA GSK3B
19 ventricular septum morphogenesis GO:0060412 9.71 WNT11 FZD1
20 epithelial to mesenchymal transition GO:0001837 9.71 WNT5A WNT11 GSK3B
21 negative chemotaxis GO:0050919 9.7 WNT5A RHOA
22 midbrain development GO:0030901 9.7 WNT5A FZD3
23 ventricular septum development GO:0003281 9.7 WNT5A WNT11
24 regulation of microtubule cytoskeleton organization GO:0070507 9.69 RHOA GSK3B
25 positive regulation of JUN kinase activity GO:0043507 9.69 WNT5A ROR2 FZD10
26 beta-catenin destruction complex disassembly GO:1904886 9.68 GSK3B FZD1
27 post-anal tail morphogenesis GO:0036342 9.68 WNT5A FZD3
28 establishment of epithelial cell apical/basal polarity GO:0045198 9.68 WNT5A RHOA
29 somite development GO:0061053 9.67 WNT5A WNT11
30 positive regulation of ossification GO:0045778 9.67 WNT5A NIPBL
31 establishment of planar polarity GO:0001736 9.67 WNT5A FZD3
32 presynapse assembly GO:0099054 9.66 WNT5A FZD1
33 secondary palate development GO:0062009 9.66 WNT5A WNT11
34 planar cell polarity pathway involved in neural tube closure GO:0090179 9.65 WNT5A FZD1
35 secondary heart field specification GO:0003139 9.65 WNT5A WNT11
36 positive regulation of protein kinase C signaling GO:0090037 9.64 WNT5A WNT11
37 atrial septum development GO:0003283 9.64 WNT5A WNT11
38 positive regulation of protein kinase C activity GO:1900020 9.63 WNT5A ROR2
39 paraxial mesoderm formation GO:0048341 9.63 WNT5A WNT11
40 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1904953 9.62 WNT5A FZD1
41 negative regulation of mesenchymal cell proliferation GO:0072201 9.61 WNT5A WNT11
42 planar cell polarity pathway involved in axon guidance GO:1904938 9.6 WNT5A FZD3
43 convergent extension involved in axis elongation GO:0060028 9.59 WNT5A WNT11
44 notochord morphogenesis GO:0048570 9.58 WNT5A WNT11
45 non-canonical Wnt signaling pathway via JNK cascade GO:0038031 9.58 WNT5A FZD10
46 positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway GO:0090082 9.56 WNT5A WNT11
47 planar cell polarity pathway involved in axis elongation GO:0003402 9.55 WNT5A WNT11
48 non-canonical Wnt signaling pathway GO:0035567 9.55 WNT5A WNT11 FZD3 FZD10 FZD1
49 primary heart field specification GO:0003138 9.52 WNT5A WNT11
50 planar cell polarity pathway involved in gastrula mediolateral intercalation GO:0060775 9.49 WNT5A WNT11

Molecular functions related to Fallopian Tube Serous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.56 WNT5B WNT5A WNT11 FZD1
2 cytokine activity GO:0005125 9.5 WNT5B WNT5A WNT11
3 Wnt-activated receptor activity GO:0042813 9.33 FZD3 FZD10 FZD1
4 Wnt-protein binding GO:0017147 9.26 ROR2 FZD3 FZD10 FZD1
5 frizzled binding GO:0005109 9.02 WNT5B WNT5A WNT11 ROR2 FZD1

Sources for Fallopian Tube Serous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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