MCID: FML311
MIFTS: 31

Familial Colorectal Cancer Type X

Categories: Gastrointestinal diseases, Rare diseases, Cancer diseases, Genetic diseases

Aliases & Classifications for Familial Colorectal Cancer Type X

Summaries for Familial Colorectal Cancer Type X

MalaCards based summary : Familial Colorectal Cancer Type X, also known as fcctx, is related to colorectal cancer and familial colorectal cancer. An important gene associated with Familial Colorectal Cancer Type X is SEMA4A (Semaphorin 4A), and among its related pathways/superpathways are TGF-beta signaling pathway (KEGG) and Loss of Function of SMAD2/3 in Cancer. Affiliated tissues include colon and testes, and related phenotypes are limbs/digits/tail and pigmentation

Related Diseases for Familial Colorectal Cancer Type X

Graphical network of the top 20 diseases related to Familial Colorectal Cancer Type X:



Diseases related to Familial Colorectal Cancer Type X

Symptoms & Phenotypes for Familial Colorectal Cancer Type X

MGI Mouse Phenotypes related to Familial Colorectal Cancer Type X:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.26 BMPR1A BRCA2 RPS20 SMAD4
2 pigmentation MP:0001186 8.8 BMPR1A RPS20 SEMA4A

Drugs & Therapeutics for Familial Colorectal Cancer Type X

Search Clinical Trials , NIH Clinical Center for Familial Colorectal Cancer Type X

Genetic Tests for Familial Colorectal Cancer Type X

Anatomical Context for Familial Colorectal Cancer Type X

MalaCards organs/tissues related to Familial Colorectal Cancer Type X:

41
Colon, Testes

Publications for Familial Colorectal Cancer Type X

Articles related to Familial Colorectal Cancer Type X:

(show all 22)
# Title Authors Year
1
Screening of BMPR1a for pathogenic mutations in familial colorectal cancer type X families from Newfoundland. ( 28660566 )
2017
2
SETD6 dominant negative mutation in familial colorectal cancer type X. ( 28973356 )
2017
3
Differential expression of CK20, I^-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X. ( 28824332 )
2017
4
Familial Colorectal Cancer Type X (FCCTX) and the correlation with various genes-A systematic review. ( 29096939 )
2017
5
Familial Colorectal Cancer Type X in Central Iran: A New Clinicopathologic Description. ( 28989591 )
2017
6
Familial Colorectal Cancer Type X. ( 29081690 )
2017
7
Clinicopathological differences between familial colorectal cancer type X and sporadic cancer in an isolated area of spain. ( 27671100 )
2016
8
Familial colorectal cancer type X: genetic profiles and phenotypic features. ( 24743215 )
2014
9
Genome-wide linkage analysis and tumoral characterization reveal heterogeneity in familial colorectal cancer type X. ( 25381643 )
2014
10
Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X. ( 25307848 )
2014
11
Characterisation of familial colorectal cancer Type X, Lynch syndrome, and non-familial colorectal cancer. ( 24918813 )
2014
12
GALNT12 is Not a Major Contributor of Familial Colorectal Cancer Type X. ( 24115450 )
2014
13
BRCA2 gene: a candidate for clinical testing in familial colorectal cancer type X. ( 24814045 )
2014
14
Comparison of clinical features between suspected familial colorectal cancer type X and Lynch syndrome in Japanese patients with colorectal cancer: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum. ( 25404568 )
2014
15
Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x. ( 23951239 )
2013
16
Hereditary colorectal cancer diagnostics: morphological features of familial colorectal cancer type X versus Lynch syndrome. ( 22287689 )
2012
17
Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X. ( 22522846 )
2012
18
Familial colorectal cancer type X: polyp burden and cancer risk stratification via a family history score. ( 22295380 )
2011
19
Familial colorectal cancer type X syndrome: two distinct molecular entities? ( 21837511 )
2011
20
Familial colorectal cancer type X: the other half of hereditary nonpolyposis colon cancer syndrome. ( 19793571 )
2009
21
[Familial colorectal cancer type X: clinical, pathological and molecular characterization]. ( 19686620 )
2009
22
Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. ( 15855431 )
2005

Variations for Familial Colorectal Cancer Type X

Expression for Familial Colorectal Cancer Type X

Search GEO for disease gene expression data for Familial Colorectal Cancer Type X.

Pathways for Familial Colorectal Cancer Type X

GO Terms for Familial Colorectal Cancer Type X

Biological processes related to Familial Colorectal Cancer Type X according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 9.52 BMPR1A SMAD4
2 transforming growth factor beta receptor signaling pathway GO:0007179 9.51 BMPR1A SMAD4
3 BMP signaling pathway GO:0030509 9.49 BMPR1A SMAD4
4 roof of mouth development GO:0060021 9.48 BMPR1A SMAD4
5 embryonic digit morphogenesis GO:0042733 9.46 BMPR1A SMAD4
6 stem cell population maintenance GO:0019827 9.43 BMPR1A SETD6
7 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.4 BMPR1A SMAD4
8 cellular response to BMP stimulus GO:0071773 9.37 BMPR1A SMAD4
9 endoderm development GO:0007492 9.32 BMPR1A SMAD4
10 developmental growth GO:0048589 9.26 BMPR1A SMAD4
11 outflow tract septum morphogenesis GO:0003148 9.16 BMPR1A SMAD4
12 female gonad development GO:0008585 8.96 BRCA2 SMAD4
13 positive regulation of SMAD protein signal transduction GO:0060391 8.62 BMPR1A SMAD4

Sources for Familial Colorectal Cancer Type X

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....