Familial Isolated Dilated Cardiomyopathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: FML304 MIFTS: 50	Familial Isolated Dilated Cardiomyopathy Categories: Cardiovascular diseases, Genetic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Familial Isolated Dilated Cardiomyopathy

MalaCards integrated aliases for Familial Isolated Dilated Cardiomyopathy:

Name: Familial Isolated Dilated Cardiomyopathy ⁵⁸ ⁶

Familial or Idiopathic Dilated Cardiomyopathy ⁵⁸

Characteristics:

Orphanet epidemiological data:

⁵⁸

familial isolated dilated cardiomyopathy
Inheritance: Autosomal dominant,Autosomal recessive,Mitochondrial inheritance,X-linked recessive; Prevalence: 1-9/100000 (Europe),1-5/10000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the circulatory system

Other forms of heart disease

Cardiomyopathy

Dilated cardiomyopathy

External Ids:

ICD10 via Orphanet ³³ I42.0

UMLS via Orphanet ⁷¹ C0340427

Orphanet ⁵⁸ ORPHA154

SNOMED-CT via HPO ⁶⁸ 129565002 195021004 248315005 more

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Summaries for Familial Isolated Dilated Cardiomyopathy

MalaCards based summary : Familial Isolated Dilated Cardiomyopathy, also known as familial or idiopathic dilated cardiomyopathy, is related to cardiomyopathy, dilated, 1b and cardiomyopathy, familial hypertrophic, 4. An important gene associated with Familial Isolated Dilated Cardiomyopathy is DSG2 (Desmoglein 2), and among its related pathways/superpathways are Cardiac conduction and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Affiliated tissues include heart, skeletal muscle and smooth muscle, and related phenotypes are dilated cardiomyopathy and sensorineural hearing impairment

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Related Diseases for Familial Isolated Dilated Cardiomyopathy

Diseases related to Familial Isolated Dilated Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)

#	Related Disease	Score	Top Affiliating Genes
1	cardiomyopathy, dilated, 1b	30.9	TNNT2 SCN5A RBM20 MYH7 MYBPC3 BAG3
2	cardiomyopathy, familial hypertrophic, 4	30.8	TNNT2 MYH7 MYBPC3 DMD
3	cardiomyopathy, dilated, 1e	30.7	SCN5A RBM20 NEXN MYH7 DES
4	atrial standstill 1	30.3	TNNT2 SCN5A RBM20 PLN NEXN MYH7
5	left ventricular noncompaction	30.0	TNNT2 SCN5A RBM20 NEXN MYPN MYH7
6	hypertrophic cardiomyopathy	30.0	TNNT2 SCN5A RBM20 PLN NEXN MYPN
7	dilated cardiomyopathy	29.9	TNNT2 SCN5A RBM20 PSEN1 PLN NEXN
8	fibroblastic rheumatism	10.5	DES ACTC1
9	extracardiac rhabdomyoma	10.5	DMD DES
10	ovarian fibrothecoma	10.5	DES ACTC1
11	cytoplasmic body myopathy	10.5	DMD DES
12	cardioneuromyopathy with hyaline masses and nemaline rods	10.5	DMD DES
13	adult cystic nephroma	10.5	DES ACTC1
14	benign metastasizing leiomyoma	10.5	DES ACTC1
15	microcolon	10.5	DMD DES
16	pulmonary vein stenosis	10.5	DES ACTC1
17	familial isolated arrhythmogenic ventricular dysplasia, left dominant form	10.5	LDB3 DSG2
18	familial isolated arrhythmogenic ventricular dysplasia, biventricular form	10.5	LDB3 DSG2
19	cutaneous leiomyosarcoma	10.5	DES ACTC1
20	scapuloperoneal syndrome, neurogenic, kaeser type	10.5	LDB3 DES
21	muscular disease	10.5	MYH7 FKTN DMD
22	botryoid rhabdomyosarcoma	10.5	DES ACTC1
23	tricuspid valve disease	10.5	TNNT2 MYH7 ACTC1
24	parachordoma	10.5	DES ACTC1
25	reducing body myopathy	10.5	DMD DES
26	myopathy, myofibrillar, 2	10.5	LDB3 CRYAB BAG3
27	left bundle branch hemiblock	10.5	TNNT2 SCN5A DSG2
28	autosomal dominant distal myopathy	10.5	MYH7 DMD DES
29	rare tumor	10.5	DES ACTC1
30	familial isolated arrhythmogenic right ventricular dysplasia	10.5	SCN5A BAG3
31	familial isolated arrhythmogenic ventricular dysplasia, right dominant form	10.5	LDB3 DSG2
32	syncope	10.5	TNNT2 SCN5A ACTN2
33	syringocystadenoma papilliferum	10.5	DES ACTC1
34	cardiomyopathy, dilated, 1dd	10.5	TNNT2 RBM20 LDB3
35	mitral valve insufficiency	10.5	TNNT2 MYH7 MYBPC3
36	megacystis-microcolon-intestinal hypoperistalsis syndrome	10.5	DMD DES ACTC1
37	angiolipoma	10.5	DES ACTC1
38	danon disease	10.5	MYH7 MYBPC3 CSRP3
39	glomangioma	10.5	DES ACTC1
40	mobitz type ii atrioventricular block	10.5	TNNT2 MYH7 LDB3 ACTC1
41	lmna-related dilated cardiomyopathy	10.5	RBM20 MYBPC3 BAG3
42	spindle cell lipoma	10.5	DES ACTC1
43	reticulum cell sarcoma	10.4	DES ACTC1
44	brugada syndrome 1	10.4	SCN5A MYBPC3 LDB3
45	myopathy, myofibrillar, 5	10.4	LDB3 DMD CRYAB BAG3
46	myopathy, spheroid body	10.4	MYPN LDB3 DES BAG3
47	cardiomyopathy, dilated, 1a	10.4	RBM20 MYBPC3 BAG3
48	bethlem myopathy 1	10.4	MYH7 FKTN DMD
49	myopathy, myofibrillar, 3	10.4	MYPN LDB3 DMD BAG3
50	ossifying fibromyxoid tumor	10.4	DES ACTC1

Graphical network of the top 20 diseases related to Familial Isolated Dilated Cardiomyopathy:

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Symptoms & Phenotypes for Familial Isolated Dilated Cardiomyopathy

Human phenotypes related to Familial Isolated Dilated Cardiomyopathy:

⁵⁸ ³¹ (show all 8)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	dilated cardiomyopathy ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001644
2	sensorineural hearing impairment ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000407
3	myopathy ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0003198
4	lipoatrophy ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0100578
5	palmoplantar keratoderma ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000982
6	elevated serum creatine kinase ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0003236
7	emg abnormality ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0003457
8	abnormality of neutrophils ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001874

MGI Mouse Phenotypes related to Familial Isolated Dilated Cardiomyopathy:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.16	ABCC9 ACTC1 BAG3 CSRP3 DES DMD
2	behavior/neurological	MP:0005386	10.1	ABCC9 BAG3 CRYAB DES DMD FKTN
3	homeostasis/metabolism	MP:0005376	10	ABCC9 ACTC1 BAG3 CRYAB CSRP3 DES
4	mortality/aging	MP:0010768	9.83	ABCC9 ACTC1 BAG3 CSRP3 DES DMD
5	muscle	MP:0005369	9.58	ABCC9 ACTC1 BAG3 CRYAB CSRP3 DES

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Drugs & Therapeutics for Familial Isolated Dilated Cardiomyopathy

Search Clinical Trials , NIH Clinical Center for Familial Isolated Dilated Cardiomyopathy

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Genetic Tests for Familial Isolated Dilated Cardiomyopathy

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Anatomical Context for Familial Isolated Dilated Cardiomyopathy

MalaCards organs/tissues related to Familial Isolated Dilated Cardiomyopathy:

⁴⁰

Heart, Skeletal Muscle, Smooth Muscle, Endothelial

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Publications for Familial Isolated Dilated Cardiomyopathy

Articles related to Familial Isolated Dilated Cardiomyopathy:

(show top 50) (show all 380)

#	Title	Authors	PMID	Year
1	Coding sequence rare variants identified in MYBPC3, MYH6, TPM1, TNNC1, and TNNI3 from 312 patients with familial or idiopathic dilated cardiomyopathy. ⁶ ⁶¹	Hershberger RE...Gonzalez-Quintana J	20215591	2010
2	Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy. ⁶¹ ⁶	Hershberger RE...Litt M	19412328	2008
3	Clinical and ECG variables to predict the outcome of genetic testing in hypertrophic cardiomyopathy. ⁶	Robyns T...Willems R	31513939	2020
4	Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3. ⁶	Kuhnisch J...Klaassen S	31568572	2019
5	A cardiac α-actin (ACTC1) p. Gly247Asp mutation inhibits SRF-signaling in vitro in neonatal rat cardiomyocytes. ⁶	Rangrez AY...Frank D	31434612	2019
6	Genetic Risk of Arrhythmic Phenotypes in Patients With Dilated Cardiomyopathy. ⁶	Gigli M...Mestroni L	31514951	2019
7	Biallelic mutation in MYH7 and MYBPC3 leads to severe cardiomyopathy with left ventricular noncompaction phenotype. ⁶	Kolokotronis K...Gerull B	30924982	2019
8	Cardiac α-Actin (ACTC1) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy. ⁶	Frank D...Schulze-Bahr E	31430208	2019
9	Recessive mutations in proximal I-band of TTN gene cause severe congenital multi-minicore disease without cardiac involvement. ⁶	Ge L...Xiong H	31053406	2019
10	Novel phenotype-genotype correlations of hypertrophic cardiomyopathy caused by mutation in α-actin and myosin-binding protein genes in three unrelated Chinese families. ⁶	Yang QL...Liu LW	30600190	2019
11	Genome sequencing as a first-line genetic test in familial dilated cardiomyopathy. ⁶	Minoche AE...Fatkin D	29961767	2019
12	Molecular characterization of Portuguese patients with dilated cardiomyopathy. ⁶	Sousa A...FATIMA investigators	30871747	2019
13	Whole-exome sequencing reveals doubly novel heterozygous Myosin Binding Protein C and Titin mutations in a Chinese patient with severe dilated cardiomyopathy. ⁶	Fan LL...Tan ZP	30109841	2018
14	Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks. ⁶	Meister-Broekema M...Kampinga HH	30559338	2018
15	Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation. ⁶	Choi SH...DiscovEHR study and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium	30535219	2018
16	Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion. ⁶	Ehsan M...Gehmlich K	30048712	2018
17	Molecular analysis of inherited cardiomyopathy using next generation semiconductor sequencing technologies. ⁶	Lu C...Zhang X	30165862	2018
18	A Reliable Targeted Next-Generation Sequencing Strategy for Diagnosis of Myopathies and Muscular Dystrophies, Especially for the Giant Titin and Nebulin Genes. ⁶	Zenagui R...Cossee M	29792937	2018
19	Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization. ⁶	Murayama R...Kuroyanagi H	29895960	2018
20	Congenital Titinopathy: Comprehensive characterization and pathogenic insights. ⁶	Oates EC...Laing NG	29691892	2018
21	Interpreting Genetic Variants in Titin in Patients With Muscle Disorders. ⁶	Savarese M...Nigro V	29435569	2018
22	Next-Generation Sequencing to Diagnose Muscular Dystrophy, Rhabdomyolysis, and HyperCKemia. ⁶	Wu L...Tarnopolsky MA	29382405	2018
23	Genetic Etiology for Alcohol-Induced Cardiac Toxicity. ⁶	Ware JS...Garcia-Pavia P	29773157	2018
24	The first titin (c.59926 + 1G > A) founder mutation associated with dilated cardiomyopathy. ⁶	Hoorntje ET...van Tintelen JP	29057560	2018
25	Mutations in BAG3 cause adult-onset Charcot-Marie-Tooth disease. ⁶	Shy M...Zuchner S	28754666	2018
26	Prevalence of Pathogenic Gene Mutations and Prognosis Do Not Differ in Isolated Left Ventricular Dysfunction Compared With Dilated Cardiomyopathy. ⁶	Hazebroek MR...Heymans S	29540472	2018
27	Genetics, Clinical Features, and Long-Term Outcome of Noncompaction Cardiomyopathy. ⁶	van Waning JI...Majoor-Krakauer D	29447731	2018
28	Phenotypic Heterogeneity within Members of a Family Carrying the Same RBM20 Mutation R634W. ⁶	Pantou MP...Degiannis D	30557877	2018
29	Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy. ⁶	Sedaghat-Hamedani F...Meder B	29029073	2017
30	Repeat genetic testing with targeted capture sequencing in primary arrhythmia syndrome and cardiomyopathy. ⁶	Robyns T...Corveleyn A	29255176	2017
31	Targeted Next-Generation Sequencing Reveals Novel TTN Mutations Causing Recessive Distal Titinopathy. ⁶	Evila A...Udd B	27796757	2017
32	Association between mutation status and left ventricular reverse remodelling in dilated cardiomyopathy. ⁶	Dal Ferro M...Sinagra G	28416588	2017
33	A 'second truncation' in TTN causes early onset recessive muscular dystrophy. ⁶	Harris E...Straub V	28716623	2017
34	Exome sequences versus sequential gene testing in the UK highly specialised Service for Limb Girdle Muscular Dystrophy. ⁶	Harris E...Straub V	28877744	2017
35	The novel αB-crystallin (CRYAB) mutation p.D109G causes restrictive cardiomyopathy. ⁶	Brodehl A...Milting H	28493373	2017
36	Multiple Gene Variants in Hypertrophic Cardiomyopathy in the Era of Next-Generation Sequencing. ⁶	Burns C...Ingles J	28790153	2017
37	Comprehensive analysis for genetic diagnosis of Dystrophinopathies in Japan. ⁶	Okubo M...Nishino I	28859693	2017
38	Diagnostic Yield of Whole Exome Sequencing in Pediatric Dilated Cardiomyopathy. ⁶	Long PA...Olson TM	29367541	2017
39	Whole Exome Sequencing Identifies Truncating Variants in Nuclear Envelope Genes in Patients With Cardiovascular Disease. ⁶	Haskell GT...Berg JS	28611029	2017
40	Utility of Post-Mortem Genetic Testing in Cases of Sudden Arrhythmic Death Syndrome. ⁶	Lahrouchi N...Behr ER	28449774	2017
41	A novel recessive TTN founder variant is a common cause of distal myopathy in the Serbian population. ⁶	Peric S...Straub V	28295036	2017
42	Truncating titin mutations are associated with a mild and treatable form of dilated cardiomyopathy. ⁶	Jansweijer JA...Pinto YM	27813223	2017
43	The sensitivity of exome sequencing in identifying pathogenic mutations for LGMD in the United States. ⁶	Reddy HM...Kang PB	27708273	2017
44	Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples. ⁶	Walsh R...Watkins H	27532257	2017
45	Massive parallel sequencing questions the pathogenic role of missense variants in dilated cardiomyopathy. ⁶	Dalin MG...Bergo MO	27886618	2017
46	Titin Truncating Variants in Dilated Cardiomyopathy - Prevalence and Genotype-Phenotype Correlations. ⁶	Franaszczyk M...Bilinska ZT	28045975	2017
47	Biallelic Mutations in MYPN, Encoding Myopalladin, Are Associated with Childhood-Onset, Slowly Progressive Nemaline Myopathy. ⁶	Miyatake S...Matsumoto N	28017374	2017
48	Clinical and Pathological Findings of a Korean Family with Pathogenic Variants of the TTN Gene. ⁶	Park HJ...Choi YC	27868403	2017
49	Additional value of screening for minor genes and copy number variants in hypertrophic cardiomyopathy. ⁶	Mademont-Soler I...Brugada R	28771489	2017
50	Hypertrophic cardiomyopathy clinical phenotype is independent of gene mutation and mutation dosage. ⁶	Viswanathan SK...Sadayappan S	29121657	2017

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Genes for Familial Isolated Dilated Cardiomyopathy

Genes related to Familial Isolated Dilated Cardiomyopathy (51 elite genes):

(show top 50) (show all 52)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	DSG2	Desmoglein 2	Protein Coding	782.23	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶ GeneCards inferred via : Variants (show sections)	18678517 20301486
2	TNNT2	Troponin T2, Cardiac Type	Protein Coding	782.23	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶ GeneCards inferred via : Variants (show sections)	8205619 18651846 28790153 (more) 9140840 23396983 27532257 11684629 15542288 20301486
3	ABCC9	ATP Binding Cassette Subfamily C Member 9	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	25590979 22610116 23307537 (more) 27316244 22608503 26871653 15034580
4	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	31430208 31434612 30600190 (more) 27532257 24793351 10966831 24736382 18506004 16611632 17611253 19799913 21622575 9563954 23283745 22590617 20301486
5	ACTN2	Actinin Alpha 2	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	25224718 20022194 17097056 (more) 25173926 27287556 14567970 20301486
6	BAG3	BAG Cochaperone 3	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	21353195 25448463 25008357 (more) 2159883 24623017 28611029 28754666 21361913 30559338 19085932 20605452 25728519 26545904 25208129 22734908 27164712 27443559 21459883 25273835 21898660 27321750 20301486
7	CRYAB	Crystallin Alpha B	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	27226619 21130652 23194663 (more) 21920752 26627873 28493373 16483541 16793013
8	CSRP3	Cysteine And Glycine Rich Protein 3	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	18505755 12642359 30048712 (more) 27353086 14567970 25351510 23396983 16352453 21425739 20301486
9	DES	Desmin	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	17325244 10430757 20301486
10	DMD	Dystrophin	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	27708273 19206170 19793655 (more) 19937601 28859693 25525159 16770791 8504498 1047858 8789442 12794683 9683584 9170407 8361506 1644931 8123157 7825571 22223181 17854090 17259292 27930565 23453023 14567970 20301486
11	FKTN	Fukutin	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	17036286 9690476 11153909 (more) 15103718 16222679 19842201
12	LDB3	LIM Domain Binding 3	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	14662268 17097056 14660611 (more) 16427346 20301486
13	MYBPC3	Myosin Binding Protein C3	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	9048664 20433692 23299917 (more) 22057632 21551322 20215591 12379228 30924982 20301486
14	MYH7	Myosin Heavy Chain 7	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	10750581 23299917 23290139 (more) 25132132 23283745 11106718 12379228 21127202 25125180 20301486
15	MYPN	Myopalladin	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	18006477 28017374 22892539
16	NEXN	Nexilin F-Actin Binding Protein	Protein Coding	775	Pathogenic ⁶ Causative germline mutation (loss of function) ⁵⁸ Likely pathogenic ⁶	19881492 20301486
17	PLN	Phospholamban	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	16432188 22707725 22820313 (more) 22155237 23568436 12639993 17655857 21167350 27532257 25611685 26535225 12610310 21282613 22427649 26917049 25593317 25928149 18241046 22137083 30871747 25563649 20301486
18	PSEN1	Presenilin 1	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	17186461 20301486
19	RBM20	RNA Binding Motif Protein 20	Protein Coding	775	Pathogenic ⁶ Pathogenic/Likely pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	27496873 24503780 19712804 (more) 20590677 21483645 23886709 26084686 23861363 26604136 22466703 22004663 30557877 29895960 29447731 29029073 29540472 2204663 20301486
20	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	775	Pathogenic ⁶ Causative germline mutation (gain of function) ⁵⁸ Likely pathogenic ⁶	19412328 22766342 22710484 (more) 22999724 15671429 14523039 3953067 15466643 12522116 15998690 16684018 20301486
21	SGCD	Sarcoglycan Delta	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	10735275 19770540 10974018 (more) 16524571 20301486
22	TNNC1	Troponin C1, Slow Skeletal And Cardiac Type	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	15542288 27574918 27604170 (more) 19439414 20459070 22489623 23425245 26304555 21056975 18572189 29255176 31513939 30165862 20301486
23	TNNI3	Troponin I3, Cardiac Type	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	31568572 12860912 15607392 (more) 15698845 21511876 22876777 19590045 15070570 20301486
24	TPM1	Tropomyosin 1	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	20117437 25548289 21310275 (more) 23539503 25241052 27532257 25525159 11273725 26688388 20301486
25	TTN	Titin	Protein Coding	775	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶	22335739 31514951 25589632 (more) 23975875 26627873 27796757 29961767 28877744 25163546 25214167 18948003 24395473 28716623 28045975 25448463 24119082 26899768 23418287 26735901 28416588 30535219 26315439 10051295 11788824 29691892 26701604 31053406 29029073 25326637 27625338 29382405 17444505 29435569 26516846 21520333 27854218 27159402 28295036 29540472 15728284 25739468 12145747 29057560 23486992 22526018 24636144 23606733 25500009 24444549 24980681 27868403 24105469 28611029 26084686 11846417 27532257 29773157 29792937 24503780 27886618 28449774 30109841 20307669 22406018 19763152 24558114 27353043 27813223 29447731 20301486
26	GATAD1	GATA Zinc Finger Domain Containing 1	Protein Coding	750	Pathogenic ⁶ Causative germline mutation ⁵⁸	21965549
27	LAMA4	Laminin Subunit Alpha 4	Protein Coding	750	Pathogenic ⁶ Causative germline mutation ⁵⁸	17646580
28	MYH6	Myosin Heavy Chain 6	Protein Coding	750	Pathogenic ⁶ Causative germline mutation ⁵⁸	15998695 20215591 20301486
29	PRDM16	PR/SET Domain 16	Protein Coding	750	Pathogenic ⁶ Causative germline mutation ⁵⁸	23768516
30	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	750	Pathogenic ⁶ Causative germline mutation ⁵⁸	24777450
31	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	750	Pathogenic ⁶ Causative germline mutation ⁵⁸	12794685 16798039 20551992
32	VCL	Vinculin	Protein Coding	750	Pathogenic ⁶ Causative germline mutation ⁵⁸	11815424 20301486
33	CEP85L	Centrosomal Protein 85 Like	Protein Coding	425	Pathogenic ⁶ Likely pathogenic ⁶	16432188 22707725 22820313 (more) 22155237 23568436 12639993 17655857 21167350 27532257 25611685 26535225 12610310 21282613 22427649 26917049 25593317 25928149 28771489 22137083 30871747 25563649
34	DSG2-AS1	DSG2 Antisense RNA 1	RNA Gene	425	Pathogenic ⁶ Likely pathogenic ⁶
35	LMNA	Lamin A/C	Protein Coding	425	Pathogenic ⁶ Likely pathogenic ⁶
36	TTN-AS1	TTN Antisense RNA 1	RNA Gene	425	Pathogenic ⁶ Likely pathogenic ⁶	22335739 31514951 25589632 (more) 23975875 26627873 27796757 29961767 28877744 25163546 25214167 18948003 24395473 28716623 28045975 25448463 24119082 26899768 23418287 26735901 28416588 30535219 26315439 29029073 25326637 27625338 29382405 17444505 29435569 26516846 21520333 27854218 27159402 28295036 29540472 15728284 25739468 12145747 29057560 23486992 22526018 24636144 23606733 25500009 24444549 24980681 27868403 24105469 28611029 26084686 27532257 29773157 29792937 24503780 27886618 28449774 30109841 20307669 22406018 19763152 24558114 27353043 27813223 26701604 29447731
37	KLF5	Kruppel Like Factor 5	Protein Coding	400	Pathogenic ⁶
38	LOC110121486	VISTA Enhancer Hs2143	Biological Region	400	Pathogenic ⁶	14662268
39	ANKRD1	Ankyrin Repeat Domain 1	Protein Coding	350	Causative germline mutation ⁵⁸	19525294 20301486
40	CAP2	Cyclase Associated Actin Cytoskeleton Regulatory Protein 2	Protein Coding	350	Causative germline mutation ⁵⁸	30518548
41	DOLK	Dolichol Kinase	Protein Coding	350	Causative germline mutation (loss of function) ⁵⁸	22242004
42	FHL2	Four And A Half LIM Domains 2	Protein Coding	350	Causative germline mutation ⁵⁸	17416352
43	HAND2	Heart And Neural Crest Derivatives Expressed 2	Protein Coding	350	Causative germline mutation (loss of function) ⁵⁸	30217752
44	PPCS	Phosphopantothenoylcysteine Synthetase	Protein Coding	350	Causative germline mutation ⁵⁸	29754768
45	PSEN2	Presenilin 2	Protein Coding	350	Causative germline mutation ⁵⁸	17186461 20301486
46	TAF1A	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit A	Protein Coding	350	Causative germline mutation ⁵⁸	28472305
47	TAFAZZIN	Tafazzin, Phospholipid-Lysophospholipid Transacylase	Protein Coding	350	Causative germline mutation ⁵⁸	7616547 9382096 20301486
48	TCAP	Titin-Cap	Protein Coding	350	Causative germline mutation ⁵⁸	15582318 19412328 20301486
49	TMPO	Thymopoietin	Protein Coding	350	Causative germline mutation ⁵⁸	16247757 20301486
50	TXNRD2	Thioredoxin Reductase 2	Protein Coding	350	Causative germline mutation (loss of function) ⁵⁸	21247928

Sources

Variations for Familial Isolated Dilated Cardiomyopathy

ClinVar genetic disease variations for Familial Isolated Dilated Cardiomyopathy:

⁶ (show top 50) (show all 14937)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	TNNI3	NM_000363.5(TNNI3):c.434G>A (p.Arg145Gln)	SNV	Pathogenic	43384	rs397516349	GRCh37: 19:55665513-55665513 GRCh38: 19:55154145-55154145
2	RAF1	NM_001354689.3(RAF1):c.788T>A (p.Val263Asp)	SNV	Pathogenic	496189	rs397516830	GRCh37: 3:12645681-12645681 GRCh38: 3:12604182-12604182
3	SCN5A	NM_198056.2(SCN5A):c.5872C>T (p.Arg1958Ter)	SNV	Pathogenic	201546	rs757532106	GRCh37: 3:38591991-38591991 GRCh38: 3:38550500-38550500
4	SCN5A	NM_198056.2(SCN5A):c.1099C>T (p.Arg367Cys)	SNV	Pathogenic	67633	rs199473097	GRCh37: 3:38648201-38648201 GRCh38: 3:38606710-38606710
5	DMD	NM_004006.2(DMD):c.10247G>A (p.Trp3416Ter)	SNV	Pathogenic	374132	rs201217593	GRCh37: X:31196064-31196064 GRCh38: X:31177947-31177947
6	DMD	NM_004006.2(DMD):c.10171C>T (p.Arg3391Ter)	SNV	Pathogenic	94428	rs398123832	GRCh37: X:31196838-31196838 GRCh38: X:31178721-31178721
7	DMD	NM_004006.2(DMD):c.3151C>T (p.Arg1051Ter)	SNV	Pathogenic	94576	rs398123929	GRCh37: X:32486626-32486626 GRCh38: X:32468509-32468509
8	MYBPC3	NM_000256.3(MYBPC3):c.2449C>T (p.Arg817Trp)	SNV	Pathogenic	164078	rs727503188	GRCh37: 11:47359095-47359095 GRCh38: 11:47337544-47337544
9	MYBPC3	NM_000256.3(MYBPC3):c.1484G>A (p.Arg495Gln)	SNV	Pathogenic	164113	rs200411226	GRCh37: 11:47364269-47364269 GRCh38: 11:47342718-47342718
10	TTN-AS1 , TTN	NM_001267550.2(TTN):c.82657G>T (p.Gly27553Ter)	SNV	Pathogenic	488810	rs869178171	GRCh37: 2:179428202-179428202 GRCh38: 2:178563475-178563475
11	SCN5A	NM_198056.2(SCN5A):c.612-229T>G	SNV	Pathogenic	587531	rs765669597	GRCh37: 3:38655554-38655554 GRCh38: 3:38614063-38614063
12	MYBPC3	NM_000256.3(MYBPC3):c.3190+5G>A	SNV	Pathogenic	155808	rs587782958	GRCh37: 11:47355103-47355103 GRCh38: 11:47333552-47333552
13	MYH7	NM_000257.4(MYH7):c.746G>A (p.Arg249Gln)	SNV	Pathogenic	14088	rs3218713	GRCh37: 14:23900677-23900677 GRCh38: 14:23431468-23431468
14	overlap with 2 genes	arr[hg19]11p11.2(47339995x2,47343435_47375684x1,47387184x2)	copy number loss	Pathogenic	635764		GRCh37: 11:47343435-47375684 GRCh38:
15	TTN-AS1 , TTN	NM_001267550.2(TTN):c.48283C>T (p.Arg16095Ter)	SNV	Pathogenic	202371	rs374140736	GRCh37: 2:179481235-179481235 GRCh38: 2:178616508-178616508
16	TTN-AS1 , TTN	NM_001267550.2(TTN):c.68308del (p.Thr22770fs)	Deletion	Pathogenic	422942	rs1064796112	GRCh37: 2:179443359-179443359 GRCh38: 2:178578632-178578632
17	BAG3	NC_000010.11:g.(?_119676454)_(119677500_?)del	Deletion	Pathogenic	645351		GRCh37: 10:121435966-121437012 GRCh38: 10:119676454-119677500
18	TTN-AS1 , TTN	NM_001267550.2(TTN):c.50296C>T (p.Arg16766Ter)	SNV	Pathogenic	202379	rs754866489	GRCh37: 2:179476842-179476842 GRCh38: 2:178612115-178612115
19	TTN-AS1 , TTN	NM_001267550.2(TTN):c.51244dup (p.Tyr17082fs)	Duplication	Pathogenic	646940	rs1576402791	GRCh37: 2:179475008-179475009 GRCh38: 2:178610281-178610282
20	TTN-AS1 , TTN	NM_001267550.2(TTN):c.84819G>A (p.Trp28273Ter)	SNV	Pathogenic	646187	rs72648222	GRCh37: 2:179426040-179426040 GRCh38: 2:178561313-178561313
21	BAG3	NM_004281.3(BAG3):c.514C>T (p.Gln172Ter)	SNV	Pathogenic	648595	rs1589630001	GRCh37: 10:121431773-121431773 GRCh38: 10:119672261-119672261
22	ABCC9	NM_005691.3(ABCC9):c.3346C>T (p.Arg1116Cys)	SNV	Pathogenic	35534	rs387907228	GRCh37: 12:21995375-21995375 GRCh38: 12:21842441-21842441
23	BAG3	NM_004281.3(BAG3):c.625C>T (p.Pro209Ser)	SNV	Pathogenic	657299	rs1589630141	GRCh37: 10:121431884-121431884 GRCh38: 10:119672372-119672372
24	CEP85L and overlap with 1 gene(s)	NC_000006.12:g.(?_118548061)_(118559090_?)del	Deletion	Pathogenic	657898		GRCh37: 6:118869224-118880253 GRCh38: 6:118548061-118559090
25	MYPN	NM_032578.3(MYPN):c.3127del (p.Ser1043fs)	Deletion	Pathogenic	661274	rs1589608098	GRCh37: 10:69955258-69955258 GRCh38: 10:68195501-68195501
26	MYH7	NM_000257.4(MYH7):c.1963C>A (p.Leu655Met)	SNV	Pathogenic	619177	rs1595084583	GRCh37: 14:23896067-23896067 GRCh38: 14:23426858-23426858
27	DMD	NM_004006.2(DMD):c.8800G>T (p.Glu2934Ter)	SNV	Pathogenic	689489	rs1603222556	GRCh37: X:31496360-31496360 GRCh38: X:31478243-31478243
28	ABCC9	NM_005691.3(ABCC9):c.4572_4573insT (p.Val1525fs)	Insertion	Pathogenic	192108	rs761784169	GRCh37: 12:21958185-21958186 GRCh38: 12:21805251-21805252
29	TNNT2	NM_001276345.2(TNNT2):c.548G>T (p.Arg183Leu)	SNV	Pathogenic	691967	rs397516471	GRCh37: 1:201332476-201332476 GRCh38: 1:201363348-201363348
30	DES	NM_001927.4(DES):c.1009G>C (p.Ala337Pro)	SNV	Pathogenic	16820	rs59962885	GRCh37: 2:220285661-220285661 GRCh38: 2:219420939-219420939
31	DMD	NM_004006.2(DMD):c.1093C>T (p.Gln365Ter)	SNV	Pathogenic	193663	rs794726993	GRCh37: X:32663137-32663137 GRCh38: X:32645020-32645020
32	TTN-AS1 , TTN	NM_001267550.2(TTN):c.106531+1G>A	SNV	Pathogenic	617573	rs760915007	GRCh37: 2:179394686-179394686 GRCh38: 2:178529959-178529959
33	TTN-AS1 , TTN	NM_001267550.2(TTN):c.95185T>C (p.Trp31729Arg)	SNV	Pathogenic	132134	rs869320741	GRCh37: 2:179410778-179410778 GRCh38: 2:178546051-178546051
34	MYBPC3	NM_000256.3(MYBPC3):c.3065G>C (p.Arg1022Pro)	SNV	Pathogenic	42682	rs397516000	GRCh37: 11:47355233-47355233 GRCh38: 11:47333682-47333682
35	TTN	NM_001267550.2(TTN):c.27607G>T (p.Glu9203Ter)	SNV	Pathogenic	801833	rs769097909	GRCh37: 2:179577042-179577042 GRCh38: 2:178712315-178712315
36	TTN	NM_001267550.2(TTN):c.19156C>T (p.Gln6386Ter)	SNV	Pathogenic	801834	rs1578126437	GRCh37: 2:179593497-179593497 GRCh38: 2:178728770-178728770
37	TTN	NM_001267550.2(TTN):c.669+1G>A	SNV	Pathogenic	801836	rs1574982376	GRCh37: 2:179664551-179664551 GRCh38: 2:178799824-178799824
38	BAG3	NM_004281.3(BAG3):c.855_859dup (p.Leu287fs)	Duplication	Pathogenic	373624	rs1057518511	GRCh37: 10:121432110-121432111 GRCh38: 10:119672598-119672599
39	GJD2-DT , ACTC1	NM_005159.5(ACTC1):c.997G>C (p.Ala333Pro)	SNV	Pathogenic	18329	rs267606629	GRCh37: 15:35082750-35082750 GRCh38: 15:34790549-34790549
40	BAG3	NM_004281.4(BAG3):c.946C>T (p.Gln316Ter)	SNV	Pathogenic	840339		GRCh37: 10:121436012-121436012 GRCh38: 10:119676500-119676500
41	TTN-AS1 , TTN	NM_001267550.2(TTN):c.75469C>T (p.Arg25157Ter)	SNV	Pathogenic	431883	rs1553603394	GRCh37: 2:179435390-179435390 GRCh38: 2:178570663-178570663
42	BAG3	NM_004281.4(BAG3):c.403C>T (p.Gln135Ter)	SNV	Pathogenic	842686		GRCh37: 10:121429585-121429585 GRCh38: 10:119670073-119670073
43	TTN-AS1 , TTN	NM_001267550.2(TTN):c.67349-2A>C	SNV	Pathogenic	242425	rs753948675	GRCh37: 2:179444577-179444577 GRCh38: 2:178579850-178579850
44	TNNT2	NM_001276345.2(TNNT2):c.616C>T (p.Arg206Trp)	SNV	Pathogenic	181625		GRCh37: 1:201331144-201331144 GRCh38: 1:201362016-201362016
45	GJD2-DT , ACTC1	NM_005159.5(ACTC1):c.76G>A (p.Asp26Asn)	SNV	Pathogenic	177917	rs727504399	GRCh37: 15:35086934-35086934 GRCh38: 15:34794733-34794733
46	MYPN	NM_032578.4(MYPN):c.295C>T (p.Arg99Ter)	SNV	Pathogenic	851819		GRCh37: 10:69881490-69881490 GRCh38: 10:68121733-68121733
47	BAG3	NM_004281.4(BAG3):c.974del (p.Pro325fs)	Deletion	Pathogenic	854159		GRCh37: 10:121436039-121436039 GRCh38: 10:119676527-119676527
48	CEP85L , PLN	NM_002667.5(PLN):c.63_64dup (p.Gln22fs)	Duplication	Pathogenic	202039	rs794729138	GRCh37: 6:118880145-118880146 GRCh38: 6:118558982-118558983
49	TTN-AS1 , TTN	NM_001267550.2(TTN):c.60579G>A (p.Trp20193Ter)	SNV	Pathogenic	859532		GRCh37: 2:179455873-179455873 GRCh38: 2:178591146-178591146
50	TTN-AS1 , TTN	NM_001267550.2(TTN):c.85768C>T (p.Arg28590Ter)	SNV	Pathogenic	488732	rs748689777	GRCh37: 2:179425091-179425091 GRCh38: 2:178560364-178560364

Sources

Expression for Familial Isolated Dilated Cardiomyopathy

Search GEO for disease gene expression data for Familial Isolated Dilated Cardiomyopathy.

Sources

Pathways for Familial Isolated Dilated Cardiomyopathy

Pathways related to Familial Isolated Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cardiac conduction ⁶⁵ Show member pathways Classical Kir channels ⁶⁵ Ion homeostasis ⁶⁵ Ion transport by P-type ATPases ⁶⁵ Muscle contraction ⁶⁵ Phase 1 - inactivation of fast Na+ channels ⁶⁵ Phase 3 - rapid repolarisation ⁶⁵ Phase 4 - resting membrane potential ⁶⁵ Physiological factors ⁶⁵ Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) ⁶⁵ Tandem pore domain halothane-inhibited K+ channel (THIK) ⁶⁵ Tandem pore domain potassium channels ⁶⁵ TWIK related potassium channel (TREK) ⁶⁵ TWIK-related alkaline pH activated K+ channel (TALK) ⁶⁵ TWIK-related spinal cord K+ channel (TRESK) ⁶⁵ TWIK-releated acid-sensitive K+ channel (TASK) ⁶⁵	12.49	TNNT2 SCN5A PLN MYBPC3 DMD DES
2	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases ²³ Show member pathways Cell adhesion Integrin-mediated cell adhesion and migration ²³ Cell adhesion Tight junctions ²³ Cytoskeleton remodeling Integrin outside-in signaling ²³ Development MAG-dependent inhibition of neurite outgrowth ²³	12.31	PSEN1 MYH7 ACTN2 ACTC1
3	cGMP-PKG signaling pathway ³⁶ Show member pathways Adrenergic signaling in cardiomyocytes ³⁶	12.16	TNNT2 SCN5A PLN MYH7 ACTC1
4	Arrhythmogenic right ventricular cardiomyopathy ³⁶ ¹	11.81	DSG2 DMD DES ACTN2
5	Dilated cardiomyopathy ³⁶ Show member pathways Hypertrophic cardiomyopathy ³⁶	11.77	TNNT2 PLN MYH7 MYBPC3 DMD DES
6	Cardiac muscle contraction ³⁶	11.55	TNNT2 MYH7 ACTC1
7	Antiarrhythmic Pathway, Pharmacodynamics ⁶⁰	11.33	SCN5A PLN ABCC9
8	Cardiac Progenitor Differentiation ¹	11.27	TNNT2 SCN5A ACTC1
9	Striated Muscle Contraction ¹ ⁶⁵	10.96	TNNT2 MYBPC3 DMD DES ACTN2 ACTC1

Sources

GO Terms for Familial Isolated Dilated Cardiomyopathy

Cellular components related to Familial Isolated Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	10.37	SCN5A PSEN1 NEXN MYPN MYH7 LDB3
2	cytoskeleton	GO:0005856	10.05	NEXN LDB3 DMD DES CSRP3 ACTN2
3	cell surface	GO:0009986	9.95	SCN5A PSEN1 DSG2 DMD CRYAB
4	axon	GO:0030424	9.83	PSEN1 NEXN MYPN DMD CRYAB
5	filopodium	GO:0030175	9.67	DMD ACTN2 ACTC1
6	stress fiber	GO:0001725	9.65	MYH7 LDB3 BAG3
7	lateral plasma membrane	GO:0016328	9.63	SCN5A DSG2 DMD
8	sarcolemma	GO:0042383	9.62	SCN5A PSEN1 DMD DES
9	intercalated disc	GO:0014704	9.58	SCN5A DSG2 DES
10	myosin filament	GO:0032982	9.57	MYH7 MYBPC3
11	pseudopodium	GO:0031143	9.56	LDB3 ACTN2
12	sarcomere	GO:0030017	9.56	TNNT2 MYPN MYH7 MYBPC3 CSRP3 ACTN2
13	contractile fiber	GO:0043292	9.54	DES CRYAB
14	myofibril	GO:0030016	9.54	TNNT2 MYH7 DMD
15	cardiac myofibril	GO:0097512	9.46	TNNT2 MYBPC3 DES CRYAB
16	I band	GO:0031674	9.43	MYPN CRYAB ACTC1
17	Z disc	GO:0030018	9.4	SCN5A PSEN1 NEXN MYPN MYH7 LDB3

Biological processes related to Familial Isolated Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesion	GO:0007155	9.95	PSEN1 NEXN MYPN MYBPC3 DSG2 ACTN2
2	heart development	GO:0007507	9.8	RBM20 PSEN1 LDB3 CSRP3
3	cellular calcium ion homeostasis	GO:0006874	9.73	PSEN1 PLN CSRP3
4	muscle organ development	GO:0007517	9.71	FKTN DMD CSRP3 CRYAB
5	muscle contraction	GO:0006936	9.65	TNNT2 MYH7 DES CRYAB ACTN2
6	regulation of heart contraction	GO:0008016	9.63	TNNT2 PLN DES
7	regulation of heart rate	GO:0002027	9.61	SCN5A MYH7 DMD
8	regulation of ryanodine-sensitive calcium-release channel activity	GO:0060314	9.58	PLN DMD
9	dendrite self-avoidance	GO:0070593	9.57	NEXN MYPN
10	regulation of cardiac muscle cell contraction	GO:0086004	9.55	SCN5A PLN
11	sarcomere organization	GO:0045214	9.55	TNNT2 MYPN LDB3 CSRP3 ACTN2
12	negative regulation of ATPase activity	GO:0032780	9.54	TNNT2 PLN
13	ventricular cardiac muscle tissue morphogenesis	GO:0055010	9.54	TNNT2 MYH7 MYBPC3
14	cardiac myofibril assembly	GO:0055003	9.52	CSRP3 ACTC1
15	response to denervation involved in regulation of muscle adaptation	GO:0014894	9.51	SCN5A DMD
16	regulation of the force of heart contraction	GO:0002026	9.5	PLN MYH7 CSRP3
17	cardiac muscle contraction	GO:0060048	9.5	TNNT2 SCN5A MYH7 MYBPC3 DMD CSRP3
18	muscle filament sliding	GO:0030049	9.17	TNNT2 MYH7 MYBPC3 DMD DES ACTN2

Molecular functions related to Familial Isolated Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATPase activity	GO:0016887	9.67	TNNT2 MYH7 ACTC1 ABCC9
2	actin filament binding	GO:0051015	9.62	NEXN MYH7 DMD ACTN2
3	cytoskeletal protein binding	GO:0008092	9.55	MYPN LDB3 DES CRYAB ACTN2
4	muscle alpha-actinin binding	GO:0051371	9.46	MYPN LDB3
5	nitric-oxide synthase binding	GO:0050998	9.43	SCN5A DMD
6	myosin binding	GO:0017022	9.43	MYBPC3 DMD ACTC1
7	titin binding	GO:0031432	9.4	MYBPC3 ACTN2
8	structural constituent of muscle	GO:0008307	9.35	NEXN MYBPC3 DMD CSRP3 ACTN2
9	actin binding	GO:0003779	9.28	TNNT2 NEXN MYPN MYH7 MYBPC3 LDB3

Sources

Sources for Familial Isolated Dilated Cardiomyopathy

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