MCID: FML353
MIFTS: 34

Familial Ovarian Cancer

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Familial Ovarian Cancer

MalaCards integrated aliases for Familial Ovarian Cancer:

Name: Familial Ovarian Cancer 58
Familial Ovarian Malignant Tumor 58

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

ICD10 via Orphanet 33 C56
Orphanet 58 ORPHA213517

Summaries for Familial Ovarian Cancer

MalaCards based summary : Familial Ovarian Cancer, also known as familial ovarian malignant tumor, is related to serous cystadenocarcinoma and breast-ovarian cancer, familial 1. An important gene associated with Familial Ovarian Cancer is BRCA1 (BRCA1 DNA Repair Associated), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include breast, ovary and testes, and related phenotypes are Decreased viability with cisplatin and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Familial Ovarian Cancer

Diseases in the Ovarian Cancer family:

Ovarian Cancer 1 Familial Ovarian Cancer

Diseases related to Familial Ovarian Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 serous cystadenocarcinoma 30.4 BRCA2 BRCA1
2 breast-ovarian cancer, familial 1 30.2 BRCA2 BRCA1
3 breast-ovarian cancer, familial 2 30.1 BRCA2 BRCA1
4 primary peritoneal carcinoma 30.1 BRCA2 BRCA1
5 fallopian tube carcinoma 29.5 ESR1 BRCA2 BRCA1
6 dysgerminoma 29.4 FGFR2 BRCA2 BRCA1
7 hereditary breast ovarian cancer syndrome 29.3 BRIP1 BRCA2 BRCA1
8 female breast cancer 29.3 ESR1 BRCA2 BRCA1
9 sporadic breast cancer 29.0 ESR1 BRCA2 BRCA1
10 ovary adenocarcinoma 29.0 ESR1 BRCA2 BRCA1
11 ovarian cancer 28.7 FGFR2 ESR1 CASP8 BRIP1 BRCA2 BRCA1
12 endometrial cancer 28.5 FGFR2 ESR1 BRCA2 BRCA1
13 fallopian tube clear cell adenocarcinoma 10.3 BRCA2 BRCA1
14 rare malignant breast tumor 10.2 BRCA2 BRCA1
15 synchronous bilateral breast carcinoma 10.2 BRCA2 BRCA1
16 ovary transitional cell carcinoma 10.2 BRCA2 BRCA1
17 hereditary site-specific ovarian cancer syndrome 10.2 BRCA2 BRCA1
18 tetraploidy 10.2 BRCA2 BRCA1
19 cancerophobia 10.2 BRCA2 BRCA1
20 basaloid lung carcinoma 10.2 BRCA2 BRCA1
21 nosophobia 10.2 BRCA2 BRCA1
22 ovarian epithelial cancer 10.2
23 endosalpingiosis 10.2 BRCA2 BRCA1
24 ovarian carcinosarcoma 10.2 BRCA2 BRCA1
25 cervical adenoma malignum 10.2 BRCA2 BRCA1
26 b-lymphoblastic leukemia/lymphoma with hyperdiploidy 10.2 BRCA2 BRCA1
27 mutagen sensitivity 10.2 BRCA2 BRCA1
28 dysplastic nevus syndrome 10.2 BRCA2 BRCA1
29 peritoneum cancer 10.2 BRCA2 BRCA1
30 premature menopause 10.2 BRCA2 BRCA1
31 lynch syndrome 10.1
32 papillary serous adenocarcinoma 10.1 BRCA2 BRCA1
33 fallopian tube disease 10.1 BRCA2 BRCA1
34 myasthenic syndrome, congenital, 6, presynaptic 10.1 BRCA2 BRCA1
35 esophageal atresia/tracheoesophageal fistula 10.1 BRIP1 BRCA2
36 ovarian cystadenocarcinoma 10.1 BRCA2 BRCA1
37 papillary adenocarcinoma 10.1 BRCA2 BRCA1
38 fanconi anemia, complementation group n 10.0 BRIP1 BRCA2
39 adenocarcinoma 10.0
40 breast cancer 10.0
41 pancreatic cancer 9.9
42 gonadoblastoma 9.9
43 testicular cancer 9.9
44 mucinous adenocarcinoma 9.9
45 appendix adenocarcinoma 9.9
46 fanconi anemia, complementation group d1 9.9 BRIP1 BRCA2 BRCA1
47 fanconi anemia, complementation group j 9.9 BRIP1 BRCA2 BRCA1
48 mulchandani-bhoj-conlin syndrome 9.8 ESR1 BRCA1
49 cowden syndrome 9.8 BRIP1 BRCA2 BRCA1
50 mixed cell type cancer 9.8 ESR1 BRCA1

Graphical network of the top 20 diseases related to Familial Ovarian Cancer:



Diseases related to Familial Ovarian Cancer

Symptoms & Phenotypes for Familial Ovarian Cancer

GenomeRNAi Phenotypes related to Familial Ovarian Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with cisplatin GR00101-A-4 9.33 BRCA1 BRCA2 BRIP1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.23 BRCA1 BRCA2
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.23 BRCA1 BRCA2 BRIP1
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.23 BRCA1 BRCA2 CASP8
5 Synthetic lethal with cisplatin GR00101-A-1 9.13 BRCA1 BRCA2 BRIP1

MGI Mouse Phenotypes related to Familial Ovarian Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 BRCA1 BRCA2 BRIP1 CASP8 ESR1 FGFR2
2 endocrine/exocrine gland MP:0005379 9.85 BRCA1 BRCA2 BRIP1 CASP8 ESR1 FGFR2
3 embryo MP:0005380 9.8 BRCA1 BRCA2 CASP8 ESR1 FGFR2
4 integument MP:0010771 9.8 BRCA1 BRCA2 BRIP1 CASP8 ESR1 FGFR2
5 limbs/digits/tail MP:0005371 9.65 BRCA1 BRCA2 BRIP1 ESR1 FGFR2
6 neoplasm MP:0002006 9.63 BRCA1 BRCA2 BRIP1 CASP8 ESR1 FGFR2
7 nervous system MP:0003631 9.43 BRCA1 BRCA2 BRIP1 CASP8 ESR1 FGFR2
8 reproductive system MP:0005389 9.02 BRCA1 BRCA2 BRIP1 ESR1 FGFR2

Drugs & Therapeutics for Familial Ovarian Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Establishing the Incidences of BRCA1 and BRCA2 Mutation by Combining DHPLC and Direct Sequencing in Ovarian Cancer Unknown status NCT00155896
2 The UK Familial Ovarian Cancer Screening Study Completed NCT00033488
3 Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer Completed NCT00040222

Search NIH Clinical Center for Familial Ovarian Cancer

Genetic Tests for Familial Ovarian Cancer

Anatomical Context for Familial Ovarian Cancer

MalaCards organs/tissues related to Familial Ovarian Cancer:

40
Breast, Ovary, Testes, T Cells

Publications for Familial Ovarian Cancer

Articles related to Familial Ovarian Cancer:

(show top 50) (show all 193)
# Title Authors PMID Year
1
Transmission of X-linked Ovarian Cancer: Characterization and Implications. 61
32046210 2020
2
Combined Tumor Sequencing and Case-Control Analyses of RAD51C in Breast Cancer. 61
30949688 2019
3
Familial Ovarian Cancer Clusters with Other Cancers. 61
30069056 2018
4
Hereditary association between testicular cancer and familial ovarian cancer: A Familial Ovarian Cancer Registry study. 61
29499525 2018
5
Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study. 61
29447163 2018
6
Integrated microRNA and mRNA signatures in peripheral blood lymphocytes of familial epithelial ovarian cancer. 61
29307835 2018
7
BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer. 61
29368626 2018
8
Elevated Serum Level of CA125 Is a Biomarker That Can Be Used to Alter Prognosis Determined by BRCA Mutation and Family History in Ovarian Cancer. 61
28799806 2017
9
Evidence of Stage Shift in Women Diagnosed With Ovarian Cancer During Phase II of the United Kingdom Familial Ovarian Cancer Screening Study. 61
28240969 2017
10
Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. 61
26707054 2016
11
Ovarian Cancer: The Fallopian Tube as the Site of Origin and Opportunities for Prevention. 61
27200296 2016
12
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. 61
26261251 2015
13
upQMPSF, a Method for the Detection of BRCA1 Exon Copy Number Variants. 61
25991562 2015
14
Higher than expected frequencies of non-ovarian cancers within a large familial ovarian cancer registry. 61
26605374 2015
15
Adapting the coping in deliberation (CODE) framework: a multi-method approach in the context of familial ovarian cancer risk management. 61
25064250 2014
16
A survey of the practice patterns of gynecologic oncologists dealing with hereditary cancer patients in Japan. 61
24853694 2014
17
The sex hormone system in carriers of BRCA1/2 mutations: a case-control study. 61
24140203 2013
18
A qualitative study of women's experiences of familial ovarian cancer screening. 61
23801640 2013
19
Role of DNA repair and cell cycle control genes in ovarian cancer susceptibility. 61
23277402 2013
20
Catalysts to withdrawal from familial ovarian cancer screening for surgery and reactions to discontinued screening: a qualitative study. 61
23014947 2013
21
Screening for familial ovarian cancer: a ray of hope and a light to steer by. 61
23213103 2013
22
Intraepithelial T cells and tumor-associated macrophages in ovarian cancer patients. 61
23390372 2013
23
Prevalence of BRCA1 mutations in familial and sporadic greek ovarian cancer cases. 61
23536787 2013
24
Results of annual screening in phase I of the United Kingdom familial ovarian cancer screening study highlight the need for strict adherence to screening schedule. 61
23213100 2013
25
Psychological outcomes of familial ovarian cancer screening: no evidence of long-term harm. 61
22943881 2012
26
Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer. 61
22843497 2012
27
[Clinical and genetic aspects of familial ovarian cancer]. 61
23156292 2012
28
Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs. 61
22488153 2012
29
Ovarian cancer screening in the high-risk population--the UK Familial Ovarian Cancer Screening Study (UKFOCSS). 61
22543917 2012
30
[Clinical aspects of familial ovarian cancer - current status and issues in Japan]. 61
22504673 2012
31
Factors influencing uptake and timing of risk reducing salpingo-oophorectomy in women at risk of familial ovarian cancer: a competing risk time to event analysis. 61
22260402 2012
32
Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer. 61
22235027 2012
33
Variants in the Signaling Protein TSAd are Associated with Susceptibility to Ovarian Cancer in BRCA1/2 Negative High Risk Families. 61
23300341 2012
34
Withdrawal from familial ovarian cancer screening for surgery: findings from a psychological evaluation study (PsyFOCS). 61
21999920 2012
35
Associations between gene expression variations and ovarian cancer risk alleles identified from genome wide association studies. 61
23133607 2012
36
Illness representations and distress in women undergoing screening for familial ovarian cancer. 61
21736431 2011
37
RAD51C is a susceptibility gene for ovarian cancer. 61
21616938 2011
38
Attitudes toward direct-to-consumer advertisements and online genetic testing among high-risk women participating in a hereditary cancer clinic. 61
21432710 2011
39
Outcome of risk-reducing salpingo-oophorectomy in BRCA carriers and women of unknown mutation status. 61
21392246 2011
40
The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing. 61
21385923 2011
41
Allelic imbalance in BRCA1 and BRCA2 gene expression and familial ovarian cancer. 61
21119070 2011
42
Breast cancer susceptibility variants alter risk in familial ovarian cancer. 61
20502973 2010
43
Novel genetic variants in miR-191 gene and familial ovarian cancer. 61
20167074 2010
44
Screening for familial ovarian cancer: poor survival of BRCA1/2 related cancers. 61
18413372 2009
45
Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer. 61
19543528 2009
46
Complex segregation analysis of pedigrees from the Gilda Radner Familial Ovarian Cancer Registry reveals evidence for mendelian dominant inheritance. 61
19536330 2009
47
Association of the ARLTS1 variants with familial ovarian cancer risk in China. 61
19509554 2009
48
Consideration of hereditary nonpolyposis colorectal cancer in BRCA mutation-negative familial ovarian cancers. 61
19117025 2009
49
The cell of origin of ovarian epithelial tumours. 61
19038766 2008
50
Recruitment to multicentre trials--lessons from UKCTOCS: descriptive study. 61
19008269 2008

Variations for Familial Ovarian Cancer

Expression for Familial Ovarian Cancer

Search GEO for disease gene expression data for Familial Ovarian Cancer.

Pathways for Familial Ovarian Cancer

Pathways related to Familial Ovarian Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1 12.39 FGFR2 ESR1 CASP8 BRCA2
2
Show member pathways
12.29 FGFR2 ESR1 BRCA2 BRCA1
3
Show member pathways
12.16 ESR1 CASP8 BRCA2 BRCA1
4 12.12 BRIP1 BRCA2 BRCA1
5
Show member pathways
12.05 FGFR2 ESR1 BRCA2 BRCA1
6
Show member pathways
11.91 BRIP1 BRCA2 BRCA1
7
Show member pathways
11.76 BRIP1 BRCA2 BRCA1
8 11.4 CASP8 BRCA1
9 11.28 CASP8 BRCA1
10 11.17 CASP8 BRCA1
11
Show member pathways
11.16 ESR1 BRCA1
12 11.11 ESR1 CASP8 BRCA2 BRCA1
13 11.1 BRIP1 BRCA2 BRCA1
14 11.02 ESR1 BRCA2

GO Terms for Familial Ovarian Cancer

Cellular components related to Familial Ovarian Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.7 FGFR2 ESR1 CASP8 BRIP1 BRCA2 BRCA1
2 protein-containing complex GO:0032991 9.26 ESR1 CASP8 BRCA2 BRCA1
3 lateral element GO:0000800 8.62 BRCA2 BRCA1

Biological processes related to Familial Ovarian Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 DNA repair GO:0006281 9.67 BRIP1 BRCA2 BRCA1
2 regulation of apoptotic process GO:0042981 9.54 ESR1 CASP8 BRCA1
3 response to estrogen GO:0043627 9.51 ESR1 BRCA1
4 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 9.48 ESR1 CASP8
5 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.46 BRCA2 BRCA1
6 nucleotide-excision repair GO:0006289 9.43 BRIP1 BRCA2
7 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.4 CASP8 BRCA1
8 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 BRCA2 BRCA1
9 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 9.26 FGFR2 ESR1
10 chordate embryonic development GO:0043009 9.16 BRCA2 BRCA1
11 double-strand break repair GO:0006302 9.13 BRIP1 BRCA2 BRCA1
12 prostate epithelial cord elongation GO:0060523 8.62 FGFR2 ESR1

Sources for Familial Ovarian Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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