FNMTC
MCID: FML211
MIFTS: 25

Familial Papillary or Follicular Thyroid Carcinoma (FNMTC)

Categories: Cancer diseases, Endocrine diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Familial Papillary or Follicular Thyroid Carcinoma

MalaCards integrated aliases for Familial Papillary or Follicular Thyroid Carcinoma:

Name: Familial Papillary or Follicular Thyroid Carcinoma 58
Familial Nonmedullary Thyroid Gland Carcinoma 70
Familial Pure Nonmedullary Thyroid Carcinoma 58
Fnmtc 58

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

ICD10 via Orphanet 33 C73
Orphanet 58 ORPHA319487
UMLS 70 C3896673

Summaries for Familial Papillary or Follicular Thyroid Carcinoma

MalaCards based summary : Familial Papillary or Follicular Thyroid Carcinoma, also known as familial nonmedullary thyroid gland carcinoma, is related to thyroid cancer, nonmedullary, 1 and thyroid cancer, nonmedullary, 2. An important gene associated with Familial Papillary or Follicular Thyroid Carcinoma is FOXE1 (Forkhead Box E1). Affiliated tissues include thyroid, spinal cord and colon, and related phenotypes are follicular thyroid carcinoma and nodular goiter

Related Diseases for Familial Papillary or Follicular Thyroid Carcinoma

Graphical network of the top 20 diseases related to Familial Papillary or Follicular Thyroid Carcinoma:



Diseases related to Familial Papillary or Follicular Thyroid Carcinoma

Symptoms & Phenotypes for Familial Papillary or Follicular Thyroid Carcinoma

Human phenotypes related to Familial Papillary or Follicular Thyroid Carcinoma:

58 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 follicular thyroid carcinoma 58 31 hallmark (90%) Very frequent (99-80%) HP:0006731
2 nodular goiter 58 31 hallmark (90%) Very frequent (99-80%) HP:0005994
3 neoplasm of head and neck 58 31 hallmark (90%) Very frequent (99-80%) HP:0012288
4 abnormality of neck blood vessel 58 31 hallmark (90%) Very frequent (99-80%) HP:3000037
5 chronic noninfectious lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002730
6 colon cancer 58 31 occasional (7.5%) Occasional (29-5%) HP:0003003
7 recurrent fractures 58 31 occasional (7.5%) Occasional (29-5%) HP:0002757
8 bone pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002653
9 spinal cord compression 58 31 occasional (7.5%) Occasional (29-5%) HP:0002176
10 papillary renal cell carcinoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0006766
11 papillary thyroid carcinoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0002895
12 chronic lung disease 58 31 occasional (7.5%) Occasional (29-5%) HP:0006528
13 goiter 58 Frequent (79-30%)
14 pain 58 Occasional (29-5%)
15 abnormality of the lymph nodes 58 Frequent (79-30%)

Drugs & Therapeutics for Familial Papillary or Follicular Thyroid Carcinoma

Search Clinical Trials , NIH Clinical Center for Familial Papillary or Follicular Thyroid Carcinoma

Genetic Tests for Familial Papillary or Follicular Thyroid Carcinoma

Anatomical Context for Familial Papillary or Follicular Thyroid Carcinoma

MalaCards organs/tissues related to Familial Papillary or Follicular Thyroid Carcinoma:

40
Thyroid, Spinal Cord, Colon, Bone, Lung, Kidney

Publications for Familial Papillary or Follicular Thyroid Carcinoma

Articles related to Familial Papillary or Follicular Thyroid Carcinoma:

(show top 50) (show all 101)
# Title Authors PMID Year
1
Familial non-medullary thyroid carcinoma: clinico-pathological features, current knowledge and novelty regarding genetic risk factors. 61
33045820 2021
2
Comparison Between Familial and Sporadic Non-medullary Thyroid Carcinoma: A Retrospective Individual Risk Factor-Matched Cohort Study. 61
32803550 2021
3
A pathogenic variant in CHEK2 shows a founder effect in Portuguese Roma patients with thyroid cancer. 61
33683595 2021
4
Is Familial Nonmedullary Thyroid Cancer A More Aggressive Type of Thyroid Cancer? 61
32761812 2021
5
Clinical features of pediatric familial non-medullary thyroid cancer (FNMTC). 61
33580435 2021
6
BROX haploinsufficiency in familial nonmedullary thyroid cancer. 61
32385852 2021
7
Role of Age at Diagnosis in Defining Potential Familial Nonmedullary Thyroid Cancer in Kindreds With Two Affected Members. 61
33175120 2021
8
Genetic Mutations and Variants in the Susceptibility of Familial Non-Medullary Thyroid Cancer. 61
33218058 2020
9
Familial non-medullary thyroid cancer: a critical review. 61
33025555 2020
10
Should Total Thyroidectomy Be Recommended for Patients with Familial Non-medullary Thyroid Cancer? 61
32556933 2020
11
An update on familial nonmedullary thyroid cancer. 61
32162184 2020
12
Lack of Mutations in POT1 Gene in Selected Families with Familial Non-Medullary Thyroid Cancer. 61
32172474 2020
13
Clinical and Genetic Features of a Large Monocentric Series of Familial Non-Medullary Thyroid Cancers. 61
33488516 2020
14
Identification of susceptibility gene mutations associated with the pathogenesis of familial nonmedullary thyroid cancer. 61
31642198 2019
15
NOP53 as A Candidate Modifier Locus for Familial Non-Medullary Thyroid Cancer. 61
31703244 2019
16
Genetic Variants Implicate Dual Oxidase-2 in Familial and Sporadic Nonmedullary Thyroid Cancer. 61
31501191 2019
17
Current Knowledge of Germline Genetic Risk Factors for the Development of Non-Medullary Thyroid Cancer. 61
31247975 2019
18
Whole exome and target sequencing identifies MAP2K5 as novel susceptibility gene for familial non-medullary thyroid carcinoma. 61
30132833 2019
19
Mutant MYO1F alters the mitochondrial network and induces tumor proliferation in thyroid cancer. 61
29672841 2018
20
Penetrance of a rare familial mutation predisposing to papillary thyroid cancer. 61
29027612 2018
21
Letter regarding the article: "Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls" by Kern et al. 61
28779995 2018
22
Frequent and Rare HABP2 Variants Are Not Associated with Increased Susceptibility to Familial Nonmedullary Thyroid Carcinoma in the Spanish Population. 61
29895015 2018
23
Hereditary and familial thyroid tumours. 61
29239041 2018
24
Second generation of familial nonmedullary thyroid carcinoma: A meta-analysis on the clinicopathologic features and prognosis. 61
28942234 2017
25
Identification of somatic TERT promoter mutations in familial nonmedullary thyroid carcinomas. 61
28502101 2017
26
Results of Screening in Familial Non-Medullary Thyroid Cancer. 61
28657510 2017
27
Papillary thyroid cancer in childhood: is parental screening helpful? 61
26470841 2017
28
Segregation and expression analyses of hyaluronan-binding protein 2 (HABP2): insights from a large series of familial non-medullary thyroid cancers and literature review. 61
28222214 2017
29
C14orf93 (RTFC) is identified as a novel susceptibility gene for familial nonmedullary thyroid cancer. 61
27864143 2017
30
[Next generation sequencing technology for susceptible gene screening in familial non-medullary thyroid carcinoma]. 61
28104029 2017
31
[A Familial Non Medullary Thyroid Carcinoma (FNMTC) : a clinical and genetic update]. 61
28387096 2016
32
Familial non-medullary thyroid cancer: unraveling the genetic maze. 61
27807061 2016
33
The impact of family history on non-medullary thyroid cancer. 61
27561845 2016
34
HABP2 germline variants are uncommon in familial nonmedullary thyroid cancer. 61
27530615 2016
35
HABP2 G534E Mutation in Familial Nonmedullary Thyroid Cancer. 61
26832773 2016
36
Clinicopathological features and prognosis of familial papillary thyroid carcinoma--a large-scale, matched, case-control study. 61
26191611 2016
37
Clinical Analysis of Familial Nonmedullary Thyroid Carcinoma. 61
26711636 2016
38
Diagnosis and Management of Hereditary Thyroid Cancer. 61
27075347 2016
39
Targeted DNA Sequencing Detects Mutations Related to Susceptibility among Familial Non-medullary Thyroid Cancer. 61
26530882 2015
40
Clinicopathologic characteristics of familial versus sporadic papillary thyroid carcinoma. 61
26824209 2015
41
RAS/BRAF mutational status in familial non-medullary thyroid carcinomas: A retrospective study. 61
26622768 2015
42
Endocrine tumours: familial nonmedullary thyroid carcinoma is a more aggressive disease: a systematic review and meta-analysis. 61
25637073 2015
43
Identification of a novel germline FOXE1 variant in patients with familial non-medullary thyroid carcinoma (FNMTC). 61
25381600 2015
44
Clinicopathologic features of familial nonmedullary thyroid carcinoma. 61
25881596 2015
45
FAP Associated Papillary Thyroid Carcinoma: A Peculiar Subtype of Familial Nonmedullary Thyroid Cancer. 61
26697262 2015
46
Familial Non-Medullary Thyroid Cancer Represents an Independent Risk Factor for Increased Cancer Aggressiveness: A Retrospective Analysis of 74 Families. 61
26284028 2015
47
Familial nonmedullary thyroid cancer: screening, clinical, molecular and genetic findings. 61
25218916 2014
48
The FOXE1 locus is a major genetic determinant for familial nonmedullary thyroid carcinoma. 61
24127282 2014
49
[Clinical and biological features of familial nonmedullary thyroid carcinoma]. 61
24785281 2014
50
Familial history of non-medullary thyroid cancer is an independent prognostic factor for tumor recurrence in younger patients with conventional papillary thyroid carcinoma. 61
24132694 2014

Variations for Familial Papillary or Follicular Thyroid Carcinoma

Expression for Familial Papillary or Follicular Thyroid Carcinoma

Search GEO for disease gene expression data for Familial Papillary or Follicular Thyroid Carcinoma.

Pathways for Familial Papillary or Follicular Thyroid Carcinoma

GO Terms for Familial Papillary or Follicular Thyroid Carcinoma

Sources for Familial Papillary or Follicular Thyroid Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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