MCID: FML028
MIFTS: 17

Familial Renal Oncocytoma

Categories: Nephrological diseases, Cancer diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Familial Renal Oncocytoma

MalaCards integrated aliases for Familial Renal Oncocytoma:

Name: Familial Renal Oncocytoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6244
NCIt 50 C8960
UMLS 73 C0879606

Summaries for Familial Renal Oncocytoma

MalaCards based summary : Familial Renal Oncocytoma is related to oncocytoma and renal oncocytoma. An important gene associated with Familial Renal Oncocytoma is FLCN (Folliculin), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and ErbB signaling pathway. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Familial Renal Oncocytoma

Diseases in the Renal Oncocytoma family:

Familial Renal Oncocytoma

Diseases related to Familial Renal Oncocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 oncocytoma 9.8
2 renal oncocytoma 9.8
3 birt-hogg-dube syndrome 9.6 FH FLCN
4 clear cell renal cell carcinoma 9.3 FLCN MET
5 autosomal genetic disease 9.2 FLCN PMS1
6 hereditary renal cell carcinoma 9.2 FH FLCN MET
7 familial renal papillary carcinoma 9.1 FH FLCN MET
8 renal cell carcinoma, papillary, 1 9.1 FH FLCN MET
9 renal cell carcinoma, nonpapillary 9.0 FH FLCN MET

Graphical network of the top 20 diseases related to Familial Renal Oncocytoma:



Diseases related to Familial Renal Oncocytoma

Symptoms & Phenotypes for Familial Renal Oncocytoma

GenomeRNAi Phenotypes related to Familial Renal Oncocytoma according to GeneCards Suite gene sharing:

26 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 10.03 MET
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 10.03 MET
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 10.03 MET FLCN
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 10.03 FLCN
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 10.03 FLCN
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 10.03 MET FLCN
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 10.03 FLCN
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 10.03 FLCN
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 10.03 MET
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 10.03 MET
11 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.47 FH
12 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.47 FLCN
13 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.47 FH
14 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.47 FLCN
15 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.47 FLCN
16 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.47 FLCN
17 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.47 FH
18 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.47 FLCN
19 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.47 FH
20 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.47 FH
21 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.47 FLCN
22 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.47 FH FLCN
23 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.47 FLCN

MGI Mouse Phenotypes related to Familial Renal Oncocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.13 FLCN MET PMS1
2 renal/urinary system MP:0005367 8.8 FH FLCN MET

Drugs & Therapeutics for Familial Renal Oncocytoma

Search Clinical Trials , NIH Clinical Center for Familial Renal Oncocytoma

Genetic Tests for Familial Renal Oncocytoma

Anatomical Context for Familial Renal Oncocytoma

Publications for Familial Renal Oncocytoma

Articles related to Familial Renal Oncocytoma:

# Title Authors Year
1
Familial renal oncocytoma: clinicopathological study of 5 families. ( 9679872 )
1998

Variations for Familial Renal Oncocytoma

Expression for Familial Renal Oncocytoma

Search GEO for disease gene expression data for Familial Renal Oncocytoma.

Pathways for Familial Renal Oncocytoma

Pathways related to Familial Renal Oncocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.42 FLCN MET
2
Show member pathways
11.25 FH FLCN MET

GO Terms for Familial Renal Oncocytoma

Biological processes related to Familial Renal Oncocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of Rho protein signal transduction GO:0035024 8.62 FLCN MET

Sources for Familial Renal Oncocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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