MCID: FML008
MIFTS: 46

Familial Retinoblastoma

Categories: Cancer diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Familial Retinoblastoma

MalaCards integrated aliases for Familial Retinoblastoma:

Name: Familial Retinoblastoma 12 15 72
Retinoblastoma 44 72
Hereditary Retinoblastoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4648
MeSH 44 D012175
NCIt 50 C8495
UMLS 72 C0035335 C0751483

Summaries for Familial Retinoblastoma

MalaCards based summary : Familial Retinoblastoma, also known as retinoblastoma, is related to retinal cancer and ocular cancer. An important gene associated with Familial Retinoblastoma is RB1 (RB Transcriptional Corepressor 1), and among its related pathways/superpathways are Cellular senescence (KEGG) and Adipogenesis. The drugs Miconazole and Itraconazole have been mentioned in the context of this disorder. Affiliated tissues include breast, eye and lung, and related phenotypes are integument and limbs/digits/tail

Related Diseases for Familial Retinoblastoma

Diseases in the Retinoblastoma family:

Familial Retinoblastoma

Diseases related to Familial Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 712)
# Related Disease Score Top Affiliating Genes
1 retinal cancer 31.6 RBL1 RB1
2 ocular cancer 31.5 RBL1 RB1
3 bilateral retinoblastoma 29.3 RBL1 RB1
4 unilateral retinoblastoma 29.1 RBL1 RB1
5 intraocular retinoblastoma 12.6
6 pediatric intraocular retinoblastoma 12.5
7 pediatric extraocular retinoblastoma 12.5
8 imprinting gene related to retinoblastoma 12.3
9 cervical cancer 11.5
10 embryoma 11.5
11 retinal disease 11.5
12 autism 3 11.5
13 norrie disease 11.1
14 leukocoria 10.7
15 retinal detachment 10.6
16 neuroblastoma 1 10.5
17 breast cancer 10.5
18 retinoblastoma 10.5
19 cataract 10.5
20 adenocarcinoma 10.4
21 exophthalmos 10.4
22 leiomyosarcoma 10.4
23 bladder cancer 10.4
24 leukemia 10.4
25 papilloma 10.4
26 squamous cell carcinoma 10.4
27 melanoma 10.4
28 adenoma 10.4
29 squamous cell papilloma 10.4
30 glioma 10.4
31 coats disease 10.4
32 glial tumor 10.4
33 lymphocytic leukemia 10.4
34 uveitis 10.3
35 cellulitis 10.3
36 colorectal cancer 10.3
37 orbital cellulitis 10.3
38 neutropenia 10.3
39 rhabdomyosarcoma 10.3
40 glioblastoma 10.3
41 blind hypotensive eye 10.3
42 melanoma, uveal 10.3
43 neovascular glaucoma 10.3
44 glioblastoma multiforme 10.3
45 medulloblastoma 10.3
46 suppressor of tumorigenicity 3 10.3
47 47,xyy 10.3
48 chromosomal triplication 10.3
49 pituitary tumors 10.3
50 prostate cancer 10.3

Graphical network of the top 20 diseases related to Familial Retinoblastoma:



Diseases related to Familial Retinoblastoma

Symptoms & Phenotypes for Familial Retinoblastoma

MGI Mouse Phenotypes related to Familial Retinoblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.46 APRT RB1 RBL1 RECQL4
2 limbs/digits/tail MP:0005371 9.13 RB1 RBL1 RECQL4
3 vision/eye MP:0005391 8.92 PDE6G RB1 RBL1 RECQL4

Drugs & Therapeutics for Familial Retinoblastoma

Drugs for Familial Retinoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 128)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
2
Itraconazole Approved, Investigational Phase 4 84625-61-6 55283
3
Nicotine Approved Phase 4 54-11-5 942 89594
4 Anti-Infective Agents Phase 4
5 Antifungal Agents Phase 4
6 Hormones Phase 4
7 Steroid Synthesis Inhibitors Phase 4
8 Hormone Antagonists Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
10 14-alpha Demethylase Inhibitors Phase 4
11 Cytochrome P-450 CYP3A Inhibitors Phase 4
12 Cytochrome P-450 Enzyme Inhibitors Phase 4
13
Hydroxyitraconazole Phase 4
14
Topotecan Approved, Investigational Phase 3 123948-87-8, 119413-54-6 60700
15
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
16
Palbociclib Approved, Investigational Phase 3 571190-30-2 5330286 11431660 5005498
17
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
18
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
19
Lactitol Investigational Phase 3 585-86-4, 585-88-6 493591
20 topoisomerase I inhibitors Phase 3
21
Liposomal doxorubicin Phase 3 31703
22 Anti-Bacterial Agents Phase 3
23 Antibiotics, Antitubercular Phase 3
24 Keratolytic Agents Phase 3
25 Podophyllotoxin Phase 3 518-28-5
26 Protein Kinase Inhibitors Phase 3
27 Estrogens Phase 3
28 Estrogen Receptor Antagonists Phase 3
29 Aromatase Inhibitors Phase 3
30 Estrogen Antagonists Phase 3
31 Mitogens Phase 3
32
Ranibizumab Approved Phase 2 347396-82-1 459903
33
Gemcitabine Approved Phase 2 95058-81-4 60750
34
Vorinostat Approved, Investigational Phase 1, Phase 2 149647-78-9 5311
35
Trastuzumab Approved, Investigational Phase 1, Phase 2 180288-69-1 9903
36
Pertuzumab Approved Phase 1, Phase 2 145040-37-5, 380610-27-5 2540
37
Anastrozole Approved, Investigational Phase 1, Phase 2 120511-73-1 2187
38
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
39
Iodine Approved, Investigational Phase 2 7553-56-2 807
40
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
41
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
42
Acetaminophen Approved Phase 2 103-90-2 1983
43
Promethazine Approved, Investigational Phase 2 60-87-7 4927
44
Diphenhydramine Approved, Investigational Phase 2 58-73-1, 147-24-0 3100
45
Goserelin Approved Phase 2 65807-02-5, 1233494-97-7 47725 5311128
46
Leuprolide Approved, Investigational Phase 2 53714-56-0 3911 657181
47
Bicalutamide Approved Phase 2 90357-06-5 56069 2375
48
Melphalan Approved Phase 2 148-82-3 460612 4053
49
Metformin Approved Phase 2 657-24-9 4091 14219
50 3-Iodobenzylguanidine Phase 2

Interventional clinical trials:

(show top 50) (show all 134)
# Name Status NCT ID Phase Drugs
1 CEV With/Without Periocular Carboplatin Chemotherapy for Nonmetastatic Extraocular Retinoblastoma Carboplatin--A Single Center, Retrospective Study to Evaluate the Efficacy of Carboplatin in Subjects With Retinoblastoma Completed NCT02319486 Phase 4 carboplatin periocular injection;CEV chemotherapy
2 Clinical Study to Evaluate the Efficacy of Prophylactic Itraconazole in High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation for Pediatric Solid Tumors Completed NCT00336531 Phase 4 itraconazole
3 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor: a Prospective, Multicentre, Randomised Controlled Trial Recruiting NCT02933333 Phase 4
4 Carboplatin Periocular Injection in the Treatment for Retinoblastoma--A Single Center, Randomized Study to Evaluate the Efficacy of Carboplatin in Subjects With Retinoblastoma Unknown status NCT02137928 Phase 3 carboplatin periocular injection;chemotherapy
5 Prospective and Randomized Study of Fixed Versus Flexible Prophylactic Administration of Granulocyte Colony-Stimulating Factor (G-CSF) in Children With Cancer Unknown status NCT01987596 Phase 3
6 Trial of Systemic Neoadjuvant Chemotherapy for Group B Intraocular Retinoblastoma Completed NCT00079417 Phase 3 carboplatin;vincristine sulfate
7 A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy Completed NCT00335738 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
8 Three Cycles Versus Six Cycles of Adjuvant Chemotherapy for the Patients With High-risk Retinoblastoma After Enucleation: Prospective Randomized Control Study Recruiting NCT01906814 Phase 3 3 cycles chemotherapy;6 cycles chemotherapy
9 GALOP II Protocol for the Treatment of Unilateral Retinoblastoma Recruiting NCT03475121 Phase 3
10 Protocol for the Study and Treatment of Patients With Intraocular Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine and Topotecan;Vincristine + Carboplatin + Etoposide;vincristine, cyclophosphamide, and doxorubicin;Vincristine, Carboplatin and Etoposide
11 A Trial of Intensive Multi-Modality Therapy for Extra-Ocular Retinoblastoma Active, not recruiting NCT00554788 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Etoposide;Thiotepa;Vincristine Sulfate
12 Phase III Study Evaluating Palbociclib (PD-0332991), a Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor in Patients With Hormone-receptor-positive, HER2-normal Primary Breast Cancer With High Relapse Risk After Neoadjuvant Chemotherapy "PENELOPEB" Active, not recruiting NCT01864746 Phase 3 Palbociclib PD-0332991;Placebo
13 Efficacy, Tolerability, and Safety of Palbociclib Combined With an Aromatase Inhibitor in Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2-negative Locally Advanced Breast Cancer Not yet recruiting NCT04047758 Phase 3 Palbociclib + Letrozole;Letrozole
14 A Single Arm Trial of Systemic And Subtenon Chemotherapy For Groups C And D Intraocular Retinoblastoma Terminated NCT00072384 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
15 Lucentis in the Treatment of Retinoblastoma - A Phase II, Single Center, Randomized Study to Evaluate the Efficacy of Ranibizumab in Subjects With Retinoblastoma Unknown status NCT01899066 Phase 2 Lucentis, chemotherapy;chemotherapy
16 Phase 1-2 Study of Injection of Melphalan Into the Ophthalmic Artery in Children With Retinoblastoma Unknown status NCT00906113 Phase 1, Phase 2 Intra-arterial injection of melphalan;Injection of melphalan into the ophthalmic artery
17 Chemotherapy Plus Local Surgical Treatment in Children With Intraocular Germ-Line Retinoblastoma Unknown status NCT00179920 Phase 2 Carboplatin;VP-16
18 Treatment for Extrachoroidal or Metastatic Retinoblastoma Completed NCT00004006 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;topotecan hydrochloride
19 Evaluation of Chemotherapy as Initial Treatment for Retinoblastoma Completed NCT00002794 Phase 2 carboplatin;vincristine sulfate
20 Intra-arterial Chemotherapy(Chemosurgery) for Retinoblastoma Completed NCT00901238 Phase 1, Phase 2
21 A TRIAL OF ADJUVANT CHEMOTHERAPY IN PATIENTS WITH INTRAOCULAR RETINOBLASTOMA Completed NCT00002675 Phase 2 carboplatin;cisplatin;cyclophosphamide;etoposide;mesna;vincristine sulfate
22 A Phase II Clinical Trail of the Cyclin Dependent Kinase (CDK)4/6 Inhibitor, PD0332991 in Previously Treated, Advanced NSCLC Patients With Wildtype Retinoblastoma Protein (RB) and Inactive Cyclin Dependent Kinase (CDK)N2a Completed NCT01291017 Phase 2 PD0332991
23 A Phase II Trial of Rebeccamycin Analogue (NSC #655649) in Children With Solid Tumors Completed NCT00006102 Phase 2 becatecarin
24 High-Dose Thiotepa With Autologous Stem Cell Rescue in Patients With Malignancies Refractory to Conventional Chemotherapy Completed NCT00003173 Phase 2 thiotepa
25 Myeloablative Chemotherapy With Bone Marrow Rescue For Rare Poor-Prognosis Cancers Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
26 A Phase II Study of IMC-A12 (Anti-IGF-I Receptor Monoclonal Antibody, NSC #742460) in Children With Relapsed/Refractory Solid Tumors Completed NCT00831844 Phase 2
27 Phase I/II Intra-patient Dose Escalation Study of Vorinostat in Children With Relapsed Solid Tumor, Lymphoma or Leukemia Completed NCT01422499 Phase 1, Phase 2 zolinza/vorinostat
28 Phase II Evaluation of Carboplatin, Paclitaxel and Gemcitabine Followed by Concurrent Cisplatin and Radiation Therapy in Patients With Locally Advanced or Recurrent Urothelial Malignancy Completed NCT00055835 Phase 2 carboplatin;cisplatin;gemcitabine hydrochloride;paclitaxel
29 Phase 2 Single- Arm Studies of Temozolomide in Combination With Topotecan in Refractory and Relapsed Neuroblastoma and Other Paediatric Solid Tumours Completed NCT00918320 Phase 2 Temozolomide/Hycamtin (Topotecan)
30 A Randomized, Open-label Therapeutic Trial Evaluating the Efficacy and Safety of Neridronate (Nerixia®) in the Treatment of Osteoporosis in Patients With Thalassemia Major and Severe Thalassemia Intermedia. Completed NCT01140321 Phase 2 Neridronate
31 Conservative Treatments of Retinoblastoma Recruiting NCT02866136 Phase 2 VP16, carboplatin;Melphalan;VP16, carboplatin, vincristin;Carboplatin + laser day 1 (chemothermotherapy);intravitreal Melphalan (local treatment)
32 Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated Recruiting NCT02870907 Phase 2 Etoposide;Vincristine;Carboplatin;Vincristine;Cyclophosphamide;Carboplatin;Etoposide;Carboplatin;Thiotepa;Vincristine;Cyclophosphamide;Carboplatin;Etoposide;Thiotepa
33 Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma Recruiting NCT01783535 Phase 2 vincristine;topotecan;filgrastim;PEG-filgrastim;carboplatin;etoposide;cyclophosphamide;MESNA;doxorubicin
34 A Phase 2 Study of Abemaciclib for Patients With Retinoblastoma-Positive, Triple Negative Metastatic Breast Cancer Recruiting NCT03130439 Phase 2 Abemaciclib
35 A Multicenter, Phase I/II Trial of Anastrozole, Palbociclib, Trastuzumab and Pertuzumab in HeR-positive, Her2-positive Metastatic Breast Cancer Recruiting NCT03304080 Phase 1, Phase 2 Anastrozole;Palbociclib;Trastuzumab;Pertuzumab
36 Randomized Phase IB/II Study of Enzalutamide With and Without Ribociclib in Patients With Metastatic Castrate Resistant, Chemotherapy Naïve Prostate Cancer That Retains RB Expression Recruiting NCT02555189 Phase 1, Phase 2 Enzalutamide;Ribociclib
37 CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma (NCT-PMO-1601) Recruiting NCT03110744 Phase 2 Palbociclib
38 A Phase I/II Dose Escalation Study of the CDK4/6 Inhibitor, Palbociclib in Combination With Cetuximab and Intensity Modulated Radiation Therapy (IMRT) for Locally Advanced Squamous Cell Carcinoma of the Head and Neck Recruiting NCT03024489 Phase 1, Phase 2 Palbociclib;Palbociclib;Palbociclib;Palbociclib;Cetuximab
39 Multicenter Phase II Study for International Intraocular Retinoblastoma Classification Groups B, C & D Tumors Treated With Carboplatin-Etoposide-Vincristine-Cyclosporine-Focal Therapy Multimodality Protocol (OCRN Multicenter RB 2003) Active, not recruiting NCT00110110 Phase 2 Carboplatin;Cyclosporine;Etoposide;vincristine sulfate
40 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
41 A Randomized Phase II Study of Androgen Deprivation Therapy With or Without Palbociclib in RB-Positive Metastatic Hormone-Sensitive Prostate Cancer Active, not recruiting NCT02059213 Phase 2 Ibrance;Bicalutamide;Zoladex;Lupron Depot
42 Targeted Therapy With CDK4/6 Inhibitors in Chemo-Refractory, Rb Wild-Type Extensive Small Cell Lung Cancer (SCLC), An Open Label Phase 2 Trial Not yet recruiting NCT04010357 Phase 2 Abemaciclib,
43 Abemaciclib for Treatment of Advanced Bone and Soft Tissue Sarcoma Identified as Having CDK Pathway Alteration Not yet recruiting NCT04040205 Phase 2 Abemaciclib
44 Phase II Study Temozolomide for Retinoblastoma Metastatic to the Central Nervous System for Patients From Guatemala Terminated NCT01857752 Phase 2 Temozolomide
45 Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma Terminated NCT01293539 Phase 2 Melphalan hydrochloride
46 A Phase II Trial of Proton Beam Radiation Therapy for Intra- and Periocular Retinoblastoma Terminated NCT00432445 Phase 2
47 An Open, Single-centre Non-randomized Phase II Clinical Trial on Intra-arterial Chemotherapy With Melphalan for the Treatment of Retinoblastoma (RTB) in Advanced Intraocular Stage Terminated NCT01393769 Phase 2 Melphalan
48 Phase II Trial of Palbociclib (PD-0332991) in Patients With Metastatic Urothelial Cancer (UC) After Failure of First-Line Chemotherapy Terminated NCT02334527 Phase 2 Palbociclib
49 A Phase II, Open Label Assessment of Neoadjuvant Intervention With Metformin Against Tumour Expression of Signaling Terminated NCT00881725 Phase 2 Metformin
50 Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma Withdrawn NCT01151748 Phase 2

Search NIH Clinical Center for Familial Retinoblastoma

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Cyclophosphamide

Cochrane evidence based reviews: retinoblastoma

Genetic Tests for Familial Retinoblastoma

Anatomical Context for Familial Retinoblastoma

MalaCards organs/tissues related to Familial Retinoblastoma:

41
Breast, Eye, Lung, Prostate, Smooth Muscle, Retina, Bone

Publications for Familial Retinoblastoma

Articles related to Familial Retinoblastoma:

(show top 50) (show all 15500)
# Title Authors PMID Year
1
Silence of lncRNA ANRIL represses cell growth and promotes apoptosis in retinoblastoma cells through regulating miR-99a and c-Myc. 38
31184221 2019
2
Hydrogel implants for transscleral drug delivery for retinoblastoma treatment. 38
31349439 2019
3
Tumor-specific inhibitory action of decorin on different hepatoma cell lines. 38
31271881 2019
4
Expression and purification of the recombinant full-length retinoblastoma protein and characterisation of its interaction with the oncoprotein HDM2. 38
31163228 2019
5
Spindle Cell Predominant Trichodiscoma or Spindle Cell Lipoma With Adnexal Induction? A Study of 25 Cases, Revealing a Subset of Cases With RB1 Heterozygous Deletion in the Spindle Cell Stroma. 38
30908293 2019
6
NEAT1 promotes retinoblastoma progression via modulating miR-124. 38
31038819 2019
7
Intra-arterial chemotherapy for retinoblastoma: the dosimetric impact. 38
31332478 2019
8
Targeting p38γ to inhibit human colorectal cancer cell progression. 38
31349971 2019
9
Tetramethylpyrazine downregulates transcription of the CXC receptor 4 (CXCR4) via nuclear respiratory factor‑1 (Nrf‑1) in WERI‑Rb1 retinoblastoma cells. 38
31322174 2019
10
Distinct biological characterization of the CD44 and CD90 phenotypes of cancer stem cells in gastric cancer cell lines. 38
31073886 2019
11
Expression Analysis of RbBP6 in human cancers: a Prospective biomarker. 38
31274515 2019
12
The role of ferroptosis in digestive system cancer. 38
31402933 2019
13
Long noncoding RNA SNHG16 promotes human retinoblastoma progression via sponging miR-140-5p. 38
31234025 2019
14
INADVERTENT INTRAOCULAR SURGERY IN CHILDREN WITH UNSUSPECTED RETINOBLASTOMA: A Study of 14 Cases. 38
29863537 2019
15
MicroRNA-503 serves an oncogenic role in retinoblastoma progression by directly targeting PTPN12. 38
31410179 2019
16
p38gamma overexpression promotes renal cell carcinoma cell growth, proliferation and migration. 38
31229268 2019
17
Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK. 38
31395901 2019
18
[Retinoblastoma in Senegal: Pathologist's view]. 38
30827691 2019
19
Erratum: Intra-arterial chemotherapy in retinoblastoma - A paradigm change. 38
31332155 2019
20
Retinoblastoma vascular perfusion and intra-arterial chemotherapy cycle requirements. 38
31432625 2019
21
Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion. 38
31189648 2019
22
Long non-coding RNAs in retinoblastoma. 38
31202519 2019
23
An analog derived from phenylpropanoids ameliorates Alzheimer's disease-like pathology and protects mitochondrial function. 38
31203190 2019
24
Knockdown of long non-coding RNA PVT1 inhibits the proliferation of Raji cells through cell cycle regulation. 38
31423183 2019
25
Functional Intronic Variant in the Retinoblastoma 1 Gene Underlies Broiler Chicken Adiposity by Altering Nuclear Factor-kB and SRY-Related HMG Box Protein 2 Binding Sites. 38
31398034 2019
26
Tumour size criteria for Group D and E eyes in the International Classification System for Retinoblastoma: effects on rates of globe salvage and high-risk histopathologic features. 38
31421017 2019
27
Intra- and interspecies comparison of EYS transcripts highlights its characteristics in the eye. 38
31120796 2019
28
Synthesis and biological evaluation of novel 99mTc-labeled palbociclib derivatives targeting cyclin-dependent kinase 4/6 (CDK4/6) as potential cancer imaging agents. 38
31424939 2019
29
Orbital Exenteration: A 23-year Report. 38
31389213 2019
30
Tumor pharmacokinetics and pharmacodynamics of the CDK4/6 inhibitor ribociclib in patients with recurrent glioblastoma. 38
31399936 2019
31
Hybrid Lipid Polymer Nanoparticles for Combined Chemo- and Photodynamic Therapy. 38
31361499 2019
32
Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins. 38
31398400 2019
33
Human CD4+ T cells specific for Merkel cell polyomavirus localize to Merkel cell carcinomas and target a required oncogenic domain. 38
31405946 2019
34
Cytoplasmic cyclin D1 regulates glioblastoma dissemination. 38
30957234 2019
35
Evaluation of the antileukemic effects of neurokinin-1 receptor antagonists, aprepitant, and L-733,060, in chronic and acute myeloid leukemic cells. 38
31306152 2019
36
Translating RB1 predictive value in clinical cancer therapy: Are we there yet? 38
31176618 2019
37
Aspirin inhibits proliferation and promotes differentiation of neuroblastoma cells via p21Waf1 protein up-regulation and Rb1 pathway modulation. 38
31429199 2019
38
Investigation of new candidate genes in retinoblastoma using the TruSight One "clinical exome" gene panel. 38
31207142 2019
39
Diversification of retinoblastoma protein function associated with cis and trans adaptations. 38
31418797 2019
40
MiR-361-5p inhibits cell proliferation and induces cell apoptosis in retinoblastoma by negatively regulating CLDN8. 38
31161266 2019
41
Temsirolimus as a dual inhibitor of retinoblastoma and angiogenesis via targeting mTOR signalling. 38
31253398 2019
42
Bilateral advanced (group D or E) intraocular retinoblastoma: outcomes in 72 Asian Indian patients. 38
30932036 2019
43
RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. 38
31138663 2019
44
MicroRNA‑330 is downregulated in retinoblastoma and suppresses cell viability and invasion by directly targeting ROCK1. 38
31432120 2019
45
Overexpression of microRNA-186 inhibits angiogenesis in retinoblastoma via the Hedgehog signaling pathway by targeting ATAD2. 38
30993715 2019
46
Retinoblastoma binding protein 4 represses HIV-1 long terminal repeat-mediated transcription by recruiting NR2F1 and histone deacetylase. 38
31435636 2019
47
Lidocaine inhibits the progression of retinoblastoma in vitro and in vivo by modulating the miR‑520a‑3p/EGFR axis. 38
31173241 2019
48
Establishment of a formal program for retinoblastoma: Feasibility of clinical coordination across borders and impact on outcome. 38
31423715 2019
49
WD repeat and SOCS box containing protein 2 in the proliferation, cycle progression, and migration of melanoma cells. 38
31103822 2019
50
Trichostatin A inhibits proliferation of PC3 prostate cancer cells by disrupting the EGFR pathway. 38
31289542 2019

Variations for Familial Retinoblastoma

Expression for Familial Retinoblastoma

Search GEO for disease gene expression data for Familial Retinoblastoma.

Pathways for Familial Retinoblastoma

Pathways related to Familial Retinoblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.53 RBL1 RB1
2 11.38 RBL1 RB1
3 11.02 RBL1 RB1
4
Show member pathways
10.67 RBL1 RB1
5 9.83 RBL1 RB1

GO Terms for Familial Retinoblastoma

Cellular components related to Familial Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 8.62 RBL1 RB1

Biological processes related to Familial Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell cycle GO:0051726 9.26 RBL1 RB1
2 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.16 RBL1 RB1
3 regulation of mitotic cell cycle GO:0007346 8.96 RBL1 RB1
4 regulation of lipid kinase activity GO:0043550 8.62 RBL1 RB1

Molecular functions related to Familial Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II activating transcription factor binding GO:0001102 8.96 RBL1 RB1
2 RNA polymerase II regulatory region DNA binding GO:0001012 8.62 RBL1 RB1

Sources for Familial Retinoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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