MCID: FML019
MIFTS: 21

Familiar Ovarian Carcinoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Familiar Ovarian Carcinoma

MalaCards integrated aliases for Familiar Ovarian Carcinoma:

Name: Familiar Ovarian Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:6901
NCIt 49 C36102
UMLS 71 C1333992

Summaries for Familiar Ovarian Carcinoma

MalaCards based summary : Familiar Ovarian Carcinoma is related to uterine corpus serous adenocarcinoma and hypertrophy of breast. An important gene associated with Familiar Ovarian Carcinoma is FGFRL1 (Fibroblast Growth Factor Receptor Like 1), and among its related pathways/superpathways are TGF-Beta Pathway and TCR Signaling (Qiagen). Affiliated tissues include breast and ovary, and related phenotypes are cardiovascular system and embryo

Related Diseases for Familiar Ovarian Carcinoma

Graphical network of the top 20 diseases related to Familiar Ovarian Carcinoma:



Diseases related to Familiar Ovarian Carcinoma

Symptoms & Phenotypes for Familiar Ovarian Carcinoma

MGI Mouse Phenotypes related to Familiar Ovarian Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 BRCA1 FGFRL1 PDGFA PDGFD PIK3CA
2 embryo MP:0005380 9.46 BRCA1 FGFRL1 PDGFA PIK3CA
3 growth/size/body region MP:0005378 9.35 BRCA1 FGFRL1 PDGFA PDGFD PIK3CA
4 muscle MP:0005369 8.92 BRCA1 FGFRL1 PDGFA PIK3CA

Drugs & Therapeutics for Familiar Ovarian Carcinoma

Search Clinical Trials , NIH Clinical Center for Familiar Ovarian Carcinoma

Genetic Tests for Familiar Ovarian Carcinoma

Anatomical Context for Familiar Ovarian Carcinoma

MalaCards organs/tissues related to Familiar Ovarian Carcinoma:

40
Breast, Ovary

Publications for Familiar Ovarian Carcinoma

Variations for Familiar Ovarian Carcinoma

Expression for Familiar Ovarian Carcinoma

Search GEO for disease gene expression data for Familiar Ovarian Carcinoma.

Pathways for Familiar Ovarian Carcinoma

Pathways related to Familiar Ovarian Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 PIK3CA PDGFD PDGFA BRCA1
2
Show member pathways
12.53 PDGFD PDGFA BRCA1
3
Show member pathways
12.5 PIK3CA PDGFD PDGFA
4
Show member pathways
12.46 PIK3CA PDGFD PDGFA
5
Show member pathways
12.39 PIK3CA PDGFD PDGFA BRCA1
6
Show member pathways
12.3 PIK3CA PDGFD PDGFA
7 12.2 PIK3CA PDGFD PDGFA
8
Show member pathways
12.14 PIK3CA PDGFD PDGFA
9 12.04 PIK3CA PDGFA BRCA1
10
Show member pathways
11.97 PIK3CA PDGFD PDGFA
11
Show member pathways
11.89 PIK3CA PDGFD PDGFA
12
Show member pathways
11.85 PIK3CA PDGFD PDGFA BRCA1
13 11.73 PIK3CA PDGFA
14 11.63 PDGFD PDGFA
15 11.51 PDGFD PDGFA
16
Show member pathways
11.51 PIK3CA PDGFD PDGFA
17 11.39 PIK3CA BRCA1
18 11.33 PIK3CA BRCA1
19 11.07 PDGFD PDGFA
20 10.16 PIK3CA PDGFD PDGFA

GO Terms for Familiar Ovarian Carcinoma

Biological processes related to Familiar Ovarian Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAP kinase activity GO:0043406 9.4 PDGFD PDGFA
2 positive regulation of fibroblast proliferation GO:0048146 9.37 PDGFD PDGFA
3 positive regulation of cell division GO:0051781 9.32 PDGFD PDGFA
4 platelet-derived growth factor receptor signaling pathway GO:0048008 9.26 PDGFD PDGFA
5 positive regulation of protein autophosphorylation GO:0031954 9.16 PDGFD PDGFA
6 regulation of peptidyl-tyrosine phosphorylation GO:0050730 8.96 PDGFD PDGFA
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.8 PIK3CA PDGFD PDGFA

Molecular functions related to Familiar Ovarian Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor receptor binding GO:0005161 8.62 PDGFD PDGFA

Sources for Familiar Ovarian Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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