FANCC
MCID: FNC044
MIFTS: 49

Fanconi Anemia, Complementation Group C (FANCC)

Categories: Blood diseases, Bone diseases, Genetic diseases, Immune diseases, Nephrological diseases

Aliases & Classifications for Fanconi Anemia, Complementation Group C

MalaCards integrated aliases for Fanconi Anemia, Complementation Group C:

Name: Fanconi Anemia, Complementation Group C 57 29 13 13 6 40 73
Fanconi Anemia Complementation Group C 12 75 15
Fancc 57 12 75
Facc 57 12 75
Fac 57 76 75
Fa3 57 12 75
Fanconi Pancytopenia Type 3 12 75
Fanconi Pancytopenia, Type 3; Fa3 57
Fanconi Pancytopenia, Type 3 57
Facc; Fac 57

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive with at least two loci and multiple alleles


HPO:

32
fanconi anemia, complementation group c:
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Fanconi Anemia, Complementation Group C

OMIM : 57 Fanconi anemia is a clinically and genetically heterogeneous disorder that causes genomic instability. Characteristic clinical features include developmental abnormalities in major organ systems, early-onset bone marrow failure, and a high predisposition to cancer. The cellular hallmark of FA is hypersensitivity to DNA crosslinking agents and high frequency of chromosomal aberrations pointing to a defect in DNA repair (summary by Deakyne and Mazin, 2011). For additional general information and a discussion of genetic heterogeneity of Fanconi anemia, see 227650. (227645)

MalaCards based summary : Fanconi Anemia, Complementation Group C, also known as fanconi anemia complementation group c, is related to fanconi anemia, complementation group a and fanconi anemia, complementation group b. An important gene associated with Fanconi Anemia, Complementation Group C is FANCC (FA Complementation Group C), and among its related pathways/superpathways are Interferon gamma signaling and Immune response IFN gamma signaling pathway. The drugs Lenograstim and beta-Hydroxy-beta-methylbutyrate have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related phenotypes are intellectual disability and hearing impairment

Disease Ontology : 12 A Fanconi anemia that has material basis in homozygous or compound heterozygous mutation in the FANCC gene on chromosome 9q22.

UniProtKB/Swiss-Prot : 75 Fanconi anemia complementation group C: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Wikipedia : 76 Jean Baptiste Point du Sable (before 1750 ? 1818) is honored as the first permanent non-Native-American... more...

Related Diseases for Fanconi Anemia, Complementation Group C

Diseases in the Fanconi Anemia, Complementation Group C family:

Fanconi Anemia, Complementation Group B

Diseases related to Fanconi Anemia, Complementation Group C via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 fanconi anemia, complementation group a 30.8 STAT1 IRF1 FANCC
2 fanconi anemia, complementation group b 11.2
3 fanconi anemia, complementation group e 11.2
4 fanconi anemia, complementation group f 11.2
5 tracheoesophageal fistula 11.2
6 multiple self-healing squamous epithelioma 11.1
7 squamous cell carcinoma, head and neck 11.1
8 fanconi anemia, complementation group d1 11.1
9 fanconi anemia, complementation group j 11.1
10 congenital hypoplastic anemia 11.1
11 tracheoesophageal fistula with or without esophageal atresia 11.0
12 isolated tracheoesophageal fistula 11.0
13 deficiency anemia 10.2
14 breast cancer 10.2
15 myocardial infarction 10.1
16 pancreatic cancer 10.1
17 venezuelan equine encephalitis 10.0 STAT1 IRF1
18 hepatocellular carcinoma 10.0
19 cervical cancer 10.0
20 myelodysplastic syndrome 10.0
21 leukemia, chronic lymphocytic 2 10.0
22 leukemia, chronic lymphocytic 10.0
23 neutropenia 10.0
24 lymphocytic leukemia 10.0
25 bowenoid papulosis 10.0
26 leukemia, b-cell, chronic 10.0
27 zika fever 9.9 STAT1 NDUFA6
28 inverted papilloma 9.9 PCNA MT2A
29 alzheimer disease 9.8
30 colorectal cancer 9.8
31 lymphoma, mucosa-associated lymphoid type 9.8
32 carney complex, type 1 9.8
33 rheumatoid arthritis 9.8
34 neutrophil actin dysfunction 9.8
35 choroideremia 9.8
36 paine syndrome 9.8
37 macular degeneration, age-related, 1 9.8
38 caronte 9.8
39 myoclonus, familial cortical 9.8
40 arthritis 9.8
41 hepatitis 9.8
42 leukemia 9.8
43 cutaneous lupus erythematosus 9.8
44 seckel syndrome 9.8
45 estrogen-receptor negative breast cancer 9.8
46 lyme disease 9.8
47 frozen shoulder 9.8
48 hemoglobinopathy 9.8
49 acute pancreatitis 9.8
50 pancreatitis 9.8

Graphical network of the top 20 diseases related to Fanconi Anemia, Complementation Group C:



Diseases related to Fanconi Anemia, Complementation Group C

Symptoms & Phenotypes for Fanconi Anemia, Complementation Group C

Symptoms via clinical synopsis from OMIM:

57
H E E N T:
microcephaly
strabismus
microphthalmia
deafness
ear anomaly

G U:
cryptorchidism
horseshoe kidney
hypergonadotropic hypogonadism
duplicated collecting system
renal ectopia
more
Neuro:
mental retardation

Skel:
radial aplasia
thumb hypoplasia
thumb deformity
thumb aplasia
duplicated thumb

Lab:
multiple chromosomal breaks
chromosomal breakage induced by diepoxybutane (deb), and mitomycin c
deficient excision of uv-induced pyrimidine dimers in dna
prolonged g2 phase of cell cycle

Heme:
anemia
pancytopenia
thrombocytopenia
neutropenia
leukemia
more
Cardiac:
congenital heart defect

Skin:
hyperpigmentation
cafe-au-lait spots
anemic pallor
bruisability
pigmentary changes

Growth:
low birth weight
small stature


Clinical features from OMIM:

227645

Human phenotypes related to Fanconi Anemia, Complementation Group C:

32 (show all 32)
# Description HPO Frequency HPO Source Accession
1 intellectual disability 32 HP:0001249
2 hearing impairment 32 HP:0000365
3 microcephaly 32 HP:0000252
4 short stature 32 HP:0004322
5 anemia 32 HP:0001903
6 pancytopenia 32 HP:0001876
7 ectopic kidney 32 HP:0000086
8 strabismus 32 HP:0000486
9 cryptorchidism 32 HP:0000028
10 horseshoe kidney 32 HP:0000085
11 thrombocytopenia 32 HP:0001873
12 microphthalmia 32 HP:0000568
13 hypergonadotropic hypogonadism 32 HP:0000815
14 neutropenia 32 HP:0001875
15 bruising susceptibility 32 HP:0000978
16 abnormality of skin pigmentation 32 HP:0001000
17 complete duplication of thumb phalanx 32 HP:0009943
18 abnormality of cardiovascular system morphology 32 HP:0030680
19 renal agenesis 32 HP:0000104
20 cafe-au-lait spot 32 HP:0000957
21 absent radius 32 HP:0003974
22 small for gestational age 32 HP:0001518
23 abnormal heart morphology 32 HP:0001627
24 short thumb 32 HP:0009778
25 leukemia 32 HP:0001909
26 duplicated collecting system 32 HP:0000081
27 absent thumb 32 HP:0009777
28 reticulocytopenia 32 HP:0001896
29 anemic pallor 32 HP:0001017
30 deficient excision of uv-induced pyrimidine dimers in dna 32 HP:0003213
31 prolonged g2 phase of cell cycle 32 HP:0003214
32 chromosomal breakage induced by crosslinking agents 32 HP:0003221

MGI Mouse Phenotypes related to Fanconi Anemia, Complementation Group C:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 FANCC FOLR1 GOLGA3 IRF1 PCNA STAT1
2 hematopoietic system MP:0005397 9.43 ERCC8 FANCC GOLGA3 IRF1 PCNA STAT1
3 neoplasm MP:0002006 8.92 ERCC8 FOLR1 IRF1 STAT1

Drugs & Therapeutics for Fanconi Anemia, Complementation Group C

Drugs for Fanconi Anemia, Complementation Group C (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 1 135968-09-1
2 beta-Hydroxy-beta-methylbutyrate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Pilot Study of CD34 Enriched, Fanconi's Anemia Complementation Group C Gene Transduced Autologous Peripheral Blood Stem Cell Transplantation in Patients With Fanconi's Anemia Unknown status NCT00005896 Phase 1 filgrastim
2 Gene Therapy for the Treatment of Fanconi's Anemia Type C Completed NCT00001399 Phase 1 Transduced CD34+ Cells
3 The Effects of β-Hydroxy-β-methylbutyrate Free Acid and High-Intensity Interval Training Completed NCT01941368 Not Applicable
4 Research Study in Healthy Volunteers of Patients With Fanconi Anemia, Myeloproliferative Disorders, or Myeloma Active, not recruiting NCT00900055
5 Spine FA3 - a Prospective, International, Multicenter Cohort Study on Treatment of of AO A3 Thoracolumbar Fractures Terminated NCT01751633

Search NIH Clinical Center for Fanconi Anemia, Complementation Group C

Genetic Tests for Fanconi Anemia, Complementation Group C

Genetic tests related to Fanconi Anemia, Complementation Group C:

# Genetic test Affiliating Genes
1 Fanconi Anemia, Complementation Group C 29 FANCC

Anatomical Context for Fanconi Anemia, Complementation Group C

MalaCards organs/tissues related to Fanconi Anemia, Complementation Group C:

41
Bone, Bone Marrow, Kidney, Heart, Skin, B Cells

Publications for Fanconi Anemia, Complementation Group C

Articles related to Fanconi Anemia, Complementation Group C:

(show all 13)
# Title Authors Year
1
Fanconi anemia complementation group C protection against oxidative stress‑induced β‑cell apoptosis. ( 29901137 )
2018
2
Fanconi Anemia complementation group C protein in metabolic disorders. ( 29930218 )
2018
3
Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. ( 15695377 )
2005
4
Intermediate DNA repair activity associated with the 322delG allele of the fanconi anemia complementation group C gene. ( 15364573 )
2004
5
Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon gamma, tumor necrosis factor-alpha, and double-stranded RNA. ( 11238103 )
2001
6
The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality. ( 11520787 )
2001
7
Fanconi anemia complementation group C is required for proliferation of murine primordial germ cells. ( 10951504 )
2000
8
Assessment of mitomycin C sensitivity in Fanconi anemia complementation group C gene (Fac) knock-out mouse cells. ( 9650445 )
1998
9
Retroviral mediated gene transfer of the Fanconi anemia complementation group C gene to hematopoietic progenitors of group C patients. ( 9322874 )
1997
10
The Fanconi anemia complementation group C protein corrects DNA interstrand cross-link-specific apoptosis in HSC536N cells. ( 8822951 )
1996
11
Clinical variability of Fanconi anemia (type C) results from expression of an amino terminal truncated Fanconi anemia complementation group C polypeptide with partial activity. ( 8639804 )
1996
12
The Fanconi anemia complementation group C gene (FAC) suppresses transformation of mutant fibroblasts by the SV40 virus. ( 8687457 )
1996
13
Identification of cytosolic proteins that bind to the Fanconi anemia complementation group C polypeptide in vitro. Evidence for a multimeric complex. ( 7730370 )
1995

Variations for Fanconi Anemia, Complementation Group C

UniProtKB/Swiss-Prot genetic disease variations for Fanconi Anemia, Complementation Group C:

75
# Symbol AA change Variation ID SNP ID
1 FANCC p.Asp195Val VAR_005228 rs1800365
2 FANCC p.Leu496Arg VAR_005232 rs121917785
3 FANCC p.Leu554Pro VAR_005233 rs104886458

ClinVar genetic disease variations for Fanconi Anemia, Complementation Group C:

6 (show top 50) (show all 215)
# Gene Variation Type Significance SNP ID Assembly Location
1 FANCC NM_000136.2(FANCC): c.1661T> C (p.Leu554Pro) single nucleotide variant Pathogenic rs104886458 GRCh37 Chromosome 9, 97864005: 97864005
2 FANCC NM_000136.2(FANCC): c.1661T> C (p.Leu554Pro) single nucleotide variant Pathogenic rs104886458 GRCh38 Chromosome 9, 95101723: 95101723
3 FANCC NM_000136.2(FANCC): c.553C> T (p.Arg185Ter) single nucleotide variant Pathogenic rs121917783 GRCh37 Chromosome 9, 97912338: 97912338
4 FANCC NM_000136.2(FANCC): c.553C> T (p.Arg185Ter) single nucleotide variant Pathogenic rs121917783 GRCh38 Chromosome 9, 95150056: 95150056
5 FANCC NM_000136.2(FANCC): c.456+4A> T single nucleotide variant Pathogenic rs104886456 GRCh37 Chromosome 9, 97934315: 97934315
6 FANCC NM_000136.2(FANCC): c.456+4A> T single nucleotide variant Pathogenic rs104886456 GRCh38 Chromosome 9, 95172033: 95172033
7 FANCC NM_000136.2(FANCC): c.37C> T (p.Gln13Ter) single nucleotide variant Pathogenic/Likely pathogenic rs121917784 GRCh37 Chromosome 9, 98011537: 98011537
8 FANCC NM_000136.2(FANCC): c.37C> T (p.Gln13Ter) single nucleotide variant Pathogenic/Likely pathogenic rs121917784 GRCh38 Chromosome 9, 95249255: 95249255
9 FANCC NM_000136.2(FANCC): c.1642C> T (p.Arg548Ter) single nucleotide variant Pathogenic/Likely pathogenic rs104886457 GRCh37 Chromosome 9, 97864024: 97864024
10 FANCC NM_000136.2(FANCC): c.1642C> T (p.Arg548Ter) single nucleotide variant Pathogenic/Likely pathogenic rs104886457 GRCh38 Chromosome 9, 95101742: 95101742
11 FANCC NM_000136.2(FANCC): c.1555dupA (p.Thr519Asnfs) duplication Pathogenic rs794726667 GRCh37 Chromosome 9, 97864111: 97864111
12 FANCC NM_000136.2(FANCC): c.1555dupA (p.Thr519Asnfs) duplication Pathogenic rs794726667 GRCh38 Chromosome 9, 95101829: 95101829
13 FANCC NM_000136.2(FANCC): c.67delG (p.Asp23Ilefs) deletion Pathogenic rs104886459 GRCh37 Chromosome 9, 98011507: 98011507
14 FANCC NM_000136.2(FANCC): c.67delG (p.Asp23Ilefs) deletion Pathogenic rs104886459 GRCh38 Chromosome 9, 95249225: 95249225
15 FANCC NM_000136.2(FANCC): c.1487T> G (p.Leu496Arg) single nucleotide variant Pathogenic rs121917785 GRCh37 Chromosome 9, 97869394: 97869394
16 FANCC NM_000136.2(FANCC): c.1487T> G (p.Leu496Arg) single nucleotide variant Pathogenic rs121917785 GRCh38 Chromosome 9, 95107112: 95107112
17 FANCC NM_000136.2(FANCC): c.165+1G> T single nucleotide variant Pathogenic rs794726668 GRCh37 Chromosome 9, 98011408: 98011408
18 FANCC NM_000136.2(FANCC): c.165+1G> T single nucleotide variant Pathogenic rs794726668 GRCh38 Chromosome 9, 95249126: 95249126
19 FANCC FANCC, 250-BP DEL deletion Pathogenic
20 FANCC NM_000136.2(FANCC): c.1374A> C (p.Arg458Ser) single nucleotide variant Uncertain significance rs56394801 GRCh37 Chromosome 9, 97869507: 97869507
21 FANCC NM_000136.2(FANCC): c.1374A> C (p.Arg458Ser) single nucleotide variant Uncertain significance rs56394801 GRCh38 Chromosome 9, 95107225: 95107225
22 FANCC NM_000136.2(FANCC): c.178G> A (p.Val60Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs138629441 GRCh37 Chromosome 9, 98009786: 98009786
23 FANCC NM_000136.2(FANCC): c.178G> A (p.Val60Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs138629441 GRCh38 Chromosome 9, 95247504: 95247504
24 FANCC NM_000136.2(FANCC): c.29G> A (p.Cys10Tyr) single nucleotide variant Uncertain significance rs143152201 GRCh37 Chromosome 9, 98011545: 98011545
25 FANCC NM_000136.2(FANCC): c.29G> A (p.Cys10Tyr) single nucleotide variant Uncertain significance rs143152201 GRCh38 Chromosome 9, 95249263: 95249263
26 FANCC NM_000136.2(FANCC): c.355_360delTCTCATinsA (p.Ser119Asnfs) indel Pathogenic/Likely pathogenic rs587779904 GRCh37 Chromosome 9, 97934415: 97934420
27 FANCC NM_000136.2(FANCC): c.355_360delTCTCATinsA (p.Ser119Asnfs) indel Pathogenic/Likely pathogenic rs587779904 GRCh38 Chromosome 9, 95172133: 95172138
28 FANCC NM_000136.2(FANCC): c.395C> G (p.Ala132Gly) single nucleotide variant Conflicting interpretations of pathogenicity rs587779905 GRCh37 Chromosome 9, 97934380: 97934380
29 FANCC NM_000136.2(FANCC): c.395C> G (p.Ala132Gly) single nucleotide variant Conflicting interpretations of pathogenicity rs587779905 GRCh38 Chromosome 9, 95172098: 95172098
30 FANCC NM_000136.2(FANCC): c.632C> G (p.Pro211Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs140781259 GRCh37 Chromosome 9, 97912259: 97912259
31 FANCC NM_000136.2(FANCC): c.632C> G (p.Pro211Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs140781259 GRCh38 Chromosome 9, 95149977: 95149977
32 FANCC NM_000136.2(FANCC): c.843+1G> A single nucleotide variant Likely pathogenic rs587779909 GRCh37 Chromosome 9, 97897627: 97897627
33 FANCC NM_000136.2(FANCC): c.843+1G> A single nucleotide variant Likely pathogenic rs587779909 GRCh38 Chromosome 9, 95135345: 95135345
34 FANCC NM_000136.2(FANCC): c.934A> G (p.Ile312Val) single nucleotide variant Conflicting interpretations of pathogenicity rs1800366 GRCh37 Chromosome 9, 97887430: 97887430
35 FANCC NM_000136.2(FANCC): c.934A> G (p.Ile312Val) single nucleotide variant Conflicting interpretations of pathogenicity rs1800366 GRCh38 Chromosome 9, 95125148: 95125148
36 FANCC NM_000136.2(FANCC): c.1156T> C (p.Ser386Pro) single nucleotide variant Conflicting interpretations of pathogenicity rs41281202 GRCh37 Chromosome 9, 97873918: 97873918
37 FANCC NM_000136.2(FANCC): c.1156T> C (p.Ser386Pro) single nucleotide variant Conflicting interpretations of pathogenicity rs41281202 GRCh38 Chromosome 9, 95111636: 95111636
38 FANCC NM_000136.2(FANCC): c.214G> A (p.Ala72Thr) single nucleotide variant Uncertain significance rs567465885 GRCh37 Chromosome 9, 98009750: 98009750
39 FANCC NM_000136.2(FANCC): c.214G> A (p.Ala72Thr) single nucleotide variant Uncertain significance rs567465885 GRCh38 Chromosome 9, 95247468: 95247468
40 FANCC NM_000136.2(FANCC): c.584A> T (p.Asp195Val) single nucleotide variant Conflicting interpretations of pathogenicity rs1800365 GRCh37 Chromosome 9, 97912307: 97912307
41 FANCC NM_000136.2(FANCC): c.584A> T (p.Asp195Val) single nucleotide variant Conflicting interpretations of pathogenicity rs1800365 GRCh38 Chromosome 9, 95150025: 95150025
42 FANCC NM_000136.2(FANCC): c.1329+181_1329+183delCCT deletion Likely benign rs587778328 GRCh37 Chromosome 9, 97873562: 97873564
43 FANCC NM_000136.2(FANCC): c.1329+181_1329+183delCCT deletion Likely benign rs587778328 GRCh38 Chromosome 9, 95111280: 95111282
44 FANCC NM_000136.2(FANCC): c.1387_1388delTC (p.Ala464Profs) deletion Pathogenic/Likely pathogenic rs730881710 GRCh38 Chromosome 9, 95107211: 95107212
45 FANCC NM_000136.2(FANCC): c.1387_1388delTC (p.Ala464Profs) deletion Pathogenic/Likely pathogenic rs730881710 GRCh37 Chromosome 9, 97869493: 97869494
46 FANCC NM_000136.2(FANCC): c.817G> A (p.Glu273Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs143181565 GRCh38 Chromosome 9, 95135372: 95135372
47 FANCC NM_000136.2(FANCC): c.817G> A (p.Glu273Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs143181565 GRCh37 Chromosome 9, 97897654: 97897654
48 FANCC NM_000136.2(FANCC): c.522-4A> G single nucleotide variant Conflicting interpretations of pathogenicity rs371422485 GRCh38 Chromosome 9, 95150091: 95150091
49 FANCC NM_000136.2(FANCC): c.522-4A> G single nucleotide variant Conflicting interpretations of pathogenicity rs371422485 GRCh37 Chromosome 9, 97912373: 97912373
50 FANCC NM_000136.2(FANCC): c.487_490delGAGA (p.Glu163Ilefs) deletion Pathogenic/Likely pathogenic rs730881708 GRCh38 Chromosome 9, 95171110: 95171113

Expression for Fanconi Anemia, Complementation Group C

Search GEO for disease gene expression data for Fanconi Anemia, Complementation Group C.

Pathways for Fanconi Anemia, Complementation Group C

Pathways related to Fanconi Anemia, Complementation Group C according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.82 IRF1 MT2A STAT1
2
Show member pathways
11.45 FANCC IRF1 STAT1
3
Show member pathways
11.34 IRF1 STAT1
4
Show member pathways
11.29 FANCC STAT1
5 11.24 IRF1 STAT1
6 10.52 IRF1 STAT1
7 10.09 FANCC PCNA

GO Terms for Fanconi Anemia, Complementation Group C

Cellular components related to Fanconi Anemia, Complementation Group C according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.43 ERCC8 FANCC GOLGA3 IRF1 PCNA STAT1
2 nucleus GO:0005634 9.23 ERCC8 FANCC FOLR1 GOLGA3 IRF1 MT2A

Biological processes related to Fanconi Anemia, Complementation Group C according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA repair GO:0006281 9.54 ERCC8 FANCC PCNA
2 transcription-coupled nucleotide-excision repair GO:0006283 9.4 ERCC8 PCNA
3 type I interferon signaling pathway GO:0060337 9.32 IRF1 STAT1
4 nucleotide-excision repair GO:0006289 9.26 ERCC8 FANCC
5 cellular response to interferon-beta GO:0035458 9.16 IRF1 STAT1
6 response to oxidative stress GO:0006979 9.13 ERCC8 NDUFA6 PCNA
7 interferon-gamma-mediated signaling pathway GO:0060333 8.8 IRF1 MT2A STAT1

Molecular functions related to Fanconi Anemia, Complementation Group C according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 8.96 FOLR1 MT2A
2 histone acetyltransferase binding GO:0035035 8.62 PCNA STAT1

Sources for Fanconi Anemia, Complementation Group C

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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