MCID: FRS001
MIFTS: 24

Far Eastern Spotted Fever

Categories: Infectious diseases

Aliases & Classifications for Far Eastern Spotted Fever

MalaCards integrated aliases for Far Eastern Spotted Fever:

Name: Far Eastern Spotted Fever 12 15 70
Rickettsia Heilongjiangensis Spotted Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050046
UMLS 70 C3532354

Summaries for Far Eastern Spotted Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia heilongjiangensis, which is transmitted by ticks (Haemaphysalis concinna). The infection has symptom fever, has symptom eschar, has symptom maculopapular rash, and has symptom regional adenopathy.

MalaCards based summary : Far Eastern Spotted Fever, also known as rickettsia heilongjiangensis spotted fever, is related to disease by infectious agent and spotted fever, and has symptoms including fever, maculopapular rash and eschar. An important gene associated with Far Eastern Spotted Fever is GLRX5 (Glutaredoxin 5), and among its related pathways/superpathways are NF-kappaB Signaling and IL12-mediated signaling events. Affiliated tissues include endothelial, and related phenotype is normal.

Related Diseases for Far Eastern Spotted Fever

Diseases related to Far Eastern Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 disease by infectious agent 30.1 IFNG HSPD1 GPT CD8A
2 spotted fever 10.4
3 brill-zinsser disease 10.3 SPTBN2 GLRX5
4 cerebral palsy, ataxic, autosomal recessive 10.3 SPTBN2 KCNC3
5 disseminated chorioretinitis 10.3 SDHB GPT
6 basidiobolomycosis 10.2 HSPD1 GPT
7 haverhill fever 10.2 LAP3 HSPD1
8 cerebellar ataxia type 9 10.2 SPTBN2 KCNC3 ATXN10
9 endemic typhus 10.2 SPTBN2 HSPD1 GLRX5
10 spinocerebellar ataxia 15 10.2 SPTBN2 KCNC3 ATXN10
11 dysferlinopathy 10.2 RELA GPT
12 opportunistic bacterial infectious disease 10.2 IFNG HSPD1
13 nocardiosis 10.2 IFNG HSPD1
14 gastrointestinal tuberculosis 10.1 IFNG GPT
15 glanders 10.1 HSPD1 CD8A
16 episodic ataxia, type 6 10.1 SPTBN2 KCNC3
17 abdominal tuberculosis 10.1 IFNG GPT
18 granulomatous hepatitis 10.1 GPT CD8A
19 necrotic uveal melanoma 10.1 IFNG CD8A
20 campylobacteriosis 10.0 IFNG HSPD1
21 hepatitis a 10.0 IFNG HAVCR2 GPT
22 skin sarcoidosis 10.0 IFNG CD8A
23 oral tuberculosis 10.0 IFNG CD8A
24 rocky mountain spotted fever 10.0 SPTBN2 HSPD1 GPT FMN1
25 retinitis pigmentosa 46 10.0 IFNG CD8A
26 uveoparotid fever 10.0 IFNG CD8A
27 macs syndrome 10.0 IFNG HSPD1 CD8A
28 primary systemic mycosis 10.0 IFNG HSPD1 CD8A
29 hemophagocytic lymphohistiocytosis 10.0 IFNG HAVCR2 GPT
30 nickel allergic contact dermatitis 9.9 IFNG CD8A
31 commensal bacterial infectious disease 9.9 IFNG HSPD1 CD8A
32 testicular disease 9.9 IFNG HSPD1 CD8A
33 scleral disease 9.9 IFNG CD8A
34 leprosy 3 9.9 IFNG HSPD1 CD8A
35 panniculitis 9.9 IFNG HAVCR2 CD8A
36 miliary tuberculosis 9.9 IFNG CD8A
37 pericardium disease 9.9 IFNG GPT CD8A
38 conjunctival disease 9.9 IFNG GPT CD8A
39 splenic disease 9.9 IFNG GPT CD8A
40 syphilis 9.9 IFNG GPT CD8A
41 chronic inflammatory demyelinating polyneuritis 9.9 IFNG CD8A
42 exanthem 9.9 IFNG GPT CD8A
43 salmonellosis 9.9 IFNG GPT CD8A
44 autoimmune disease of gastrointestinal tract 9.9 IFNG GPT CD8A
45 parasitic protozoa infectious disease 9.9 IFNG GPT CD8A
46 cerebellar disease 9.8 SPTBN2 KCNC3 ATXN10
47 lymph node disease 9.8 SDHB IFNG HSPD1 CD8A
48 epidemic typhus 9.8 SPTBN2 HSPD1 GPT GLRX5 CD8A
49 primary bacterial infectious disease 9.8 IFNG HSPD1 GPT CD8A
50 mucocutaneous leishmaniasis 9.8 IFNG CD8A

Graphical network of the top 20 diseases related to Far Eastern Spotted Fever:



Diseases related to Far Eastern Spotted Fever

Symptoms & Phenotypes for Far Eastern Spotted Fever

Symptoms:

12
  • fever
  • maculopapular rash
  • eschar
  • regional adenopathy

MGI Mouse Phenotypes related to Far Eastern Spotted Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.23 ATXN10 CD8A CFD FMN1 IFNG KCNC3

Drugs & Therapeutics for Far Eastern Spotted Fever

Search Clinical Trials , NIH Clinical Center for Far Eastern Spotted Fever

Genetic Tests for Far Eastern Spotted Fever

Anatomical Context for Far Eastern Spotted Fever

MalaCards organs/tissues related to Far Eastern Spotted Fever:

40
Endothelial

Publications for Far Eastern Spotted Fever

Articles related to Far Eastern Spotted Fever:

# Title Authors PMID Year
1
Genomic Features of Rickettsia heilongjiangensis Revealed by Intraspecies Comparison and Detailed Comparison With Rickettsia japonica. 61
31866968 2019
2
Identification of a Ribosomal Protein RpsB as a Surface-Exposed Protein and Adhesin of Rickettsia heilongjiangensis. 61
31360728 2019
3
Enhanced Expression of T-Cell Immunoglobulin and Mucin Domain Protein 3 in Endothelial Cells Facilitates Intracellular Killing of Rickettsia heilongjiangensis. 61
26401029 2016
4
Genomic and comparative genomic analyses of Rickettsia heilongjiangensis provide insight into its evolution and pathogenesis. 61
24924907 2014
5
Microarray of surface-exposed proteins of Rickettsia heilongjiangensis for serodiagnosis of Far-eastern spotted fever. 61
24938647 2014
6
Recombinant protein YbgF induces protective immunity against Rickettsia heilongjiangensis infection in C3H/HeN mice. 61
24113261 2013
7
Proteome analysis and serological characterization of surface-exposed proteins of Rickettsia heilongjiangensis. 61
23894656 2013
8
Complete genome sequence of Rickettsia heilongjiangensis, an emerging tick-transmitted human pathogen. 61
21914880 2011
9
Exploratory study on pathogenesis of far-eastern spotted fever. 61
21896812 2011
10
[Far-eastern spotted fever: description of new infectious disease]. 61
18756784 2008

Variations for Far Eastern Spotted Fever

Expression for Far Eastern Spotted Fever

Search GEO for disease gene expression data for Far Eastern Spotted Fever.

Pathways for Far Eastern Spotted Fever

Pathways related to Far Eastern Spotted Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.97 RELA IFNG HAVCR2 CD8A
2
Show member pathways
11.18 RELA IFNG CD8A
3 10.81 VCL RELA IFNG

GO Terms for Far Eastern Spotted Fever

Biological processes related to Far Eastern Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of amyloid-beta formation GO:1902004 9.32 RELA IFNG
2 positive regulation of macrophage activation GO:0043032 9.26 HSPD1 HAVCR2
3 macrophage activation involved in immune response GO:0002281 9.16 IFNG HAVCR2
4 cellular response to stress GO:0033554 8.96 RELA PRDX2
5 positive regulation of interleukin-12 production GO:0032735 8.8 RELA IFNG HSPD1

Molecular functions related to Far Eastern Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 8.92 VCL RELA HSPD1 CBSL

Sources for Far Eastern Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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