Farmer's Lung disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Farmer's lung disease is the main form of occupational hypersensitivity pneumonitis (see this term), caused by chronic inhalation of microorganisms, often thermophilic actinomycetes and less commonly saccharopolyspora rectivirgula, living in mouldy hay, straw, or grain. It is characterized by variable degrees of dyspnea, cough, tiredness, headaches and occasional fever/night sweats, with acute, sub-acute or chronic clinical course

MalaCards based summary: Farmer's Lung, also known as farmer lung, is related to interstitial lung disease and actinomycosis. An important gene associated with Farmer's Lung is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Defensins. Affiliated tissues include lung, skin and b cells, and related phenotypes are immune system and hematopoietic system

Orphanet: ⁵⁸ Farmer's lung disease is the main form of occupational hypersensitivity pneumonitis (see this term), caused by chronic inhalation of microorganisms, often thermophilic actinomycetes and less commonly saccharopolyspora rectivirgula, living in mouldy hay, straw, or grain. It is characterized by variable degrees of dyspnea, cough, tiredness, headaches and occasional fever/night sweats, with acute, sub-acute or chronic clinical course

Disease Ontology: ¹¹ An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

Wikipedia: ⁷⁵ Farmer's lung (not to be confused with silo-filler's disease) is a hypersensitivity pneumonitis induced... more...

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Related Diseases for Farmer's Lung

Diseases related to Farmer's Lung via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 584)

#	Related Disease	Score	Top Affiliating Genes
1	interstitial lung disease	31.9	TNF SERPINA3 CCR6
2	actinomycosis	31.3	TNF CD4
3	aspergillosis	30.9	TNF SLPI ELANE CCR6
4	bronchitis	30.8	TNF SLPI IGHE ELANE
5	lung disease	30.8	TNF SLPI SERPINA3 PI3 ELANE CCR6
6	bird fancier's lung	30.3	CD8A CD4
7	proteasome-associated autoinflammatory syndrome 1	30.2	TNF IGHE ELANE
8	extrinsic allergic alveolitis	30.0	TNF PI3 IGHE ELANE CD8A CD4
9	ventilation pneumonitis	30.0	CD8A CD4
10	pulmonary emphysema	30.0	SLPI SERPINA3 ELANE
11	dermatitis	29.9	TNF IL2 IGHE CCR6
12	histoplasmosis	29.9	TNF CD4 CCR6
13	allergic bronchopulmonary aspergillosis	29.9	IGHE CD4 CCR6
14	hypersensitivity reaction type iii disease	29.6	TNF SERPINA3 CD4 CCR6
15	pneumonia	29.6	TNF SLPI ELANE CD8A
16	asthma	29.5	TNF SERPINA3 IL2 IGHE ELANE CD4
17	chronic granulomatous disease	29.5	TNF CD8A CD4
18	immunoglobulin alpha deficiency	29.5	CD8A CD4 CCR6
19	allergic disease	29.4	TNF SERPINA3 IL2 IGHE CD8A CD4
20	adult t-cell leukemia/lymphoma	29.3	IL2 CD8A CD4 CCR6
21	polyclonal hypergammaglobulinemia	29.2	SERPINA3 CD8A CD4 CCR6
22	t-cell acute lymphoblastic leukemia	29.2	IL2 CD8A CD4 CCR6
23	celiac disease 1	29.1	TNF SERPINA3 IL2 CD8A CD4 CCR6
24	fungal infectious disease	29.1	TNF IL2 CD8A CD4 CCR6
25	respiratory failure	29.1	TNF SERPINA3 IL2 IGHE ELANE CD8A
26	sarcoidosis 1	28.8	TNF SERPINA3 IL2 CD8A CD4 CCR6
27	dermatitis, atopic	28.6	TNF SERPINA3 IL2 IGHE CD8A CD4
28	interstitial lung disease 2	28.5	TNF SERPINA3 IL2 ELANE CD8A CD4
29	ceroid lipofuscinosis, neuronal, 5	10.5
30	pulmonary fibrosis	10.4
31	acute graft versus host disease	10.3	TNF IL2
32	nut allergy	10.2	IGHE CCR6
33	arthrogryposis, renal dysfunction, and cholestasis 1	10.2
34	corneal abscess	10.2	SLPI PI3
35	conjunctivitis	10.2	TNF IL2 IGHE
36	intestinal tuberculosis	10.2	TNF CD4
37	aspiration pneumonitis	10.2	TNF SERPINA3
38	schistosomiasis	10.2	TNF IL2 IGHE
39	elephantiasis	10.2	ELANE CD4
40	clonorchiasis	10.2	TNF IL2 IGHE
41	sapho syndrome	10.2	TNF CCR6
42	pericardial tuberculosis	10.2	TNF CD4
43	funisitis	10.2	TNF CCR6
44	transient arthritis	10.2	TNF CD4
45	optic papillitis	10.2	TNF CD4
46	exocrine pancreatic insufficiency	10.2	TNF IGHE ELANE
47	lymph node tuberculosis	10.2	TNF CD4
48	toxic megacolon	10.2	TNF CCR6
49	nocardiosis	10.2	TNF CD4
50	arachnoiditis	10.2	TNF CD4

Comorbidity relations with Farmer's Lung via Phenotypic Disease Network (PDN):

Heart Disease

Graphical network of the top 20 diseases related to Farmer's Lung:

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Symptoms & Phenotypes for Farmer's Lung

MGI Mouse Phenotypes related to Farmer's Lung:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.73	CCR6 CD36 CD4 CD8A CHTOP CRIP3
2	hematopoietic system	MP:0005397	9.4	CCR6 CD36 CD4 CD8A CHTOP CRIP3

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Drugs & Therapeutics for Farmer's Lung

Search Clinical Trials, NIH Clinical Center for Farmer's Lung

Cochrane evidence based reviews: farmer's lung

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Genetic Tests for Farmer's Lung

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Anatomical Context for Farmer's Lung

Organs/tissues related to Farmer's Lung:

MalaCards : Lung, Skin, B Cells, T Cells, Neutrophil, Pituitary

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Publications for Farmer's Lung

Articles related to Farmer's Lung:

(show top 50) (show all 766)

#	Title	Authors	PMID	Year
1	[Relationship between severity of farmer's lung and the level of soluble interleukin 2 receptors in serum]. ⁵³ ⁶²	Fukuzawa J...Kikuchi K	8937141	1996
2	[A study on interleukin 2 and soluble interleukin 2 receptor in serum and bronchoalveolar lavage fluid from patients with farmer's lung]. ⁵³ ⁶²	Ninomiya Y...Konishi K	1770680	1991
3	Prevalence and Risk Factors for Pulmonary Conditions among Farmers and Ranchers in the Central United States. ⁶²	Puvvula J...Rautiainen RH	35026966	2022
4	Antigen avoidance and environmental inhalation challenge for successful diagnosis of fibrotic hypersensitivity pneumonitis mimicking idiopathic pulmonary fibrosis. ⁶²	Ito Y...Shirai M	36133420	2022
5	[Hypersensitivity Pneumonitis: An update]. ⁶²	Chauvin P...Lescoat A	33941410	2021
6	Occupational lung disease: A narrative review of lung conditions from the workplace. ⁶²	Jumat MI...Kadir F	33854771	2021
7	Sooty bark disease of maples: the risk for hypersensitivity pneumonitis by fungal spores not only for woodman. ⁶²	Braun M...Groneberg DA	33478566	2021
8	Studying smoking benefit in farmer's lung to understand Covid-19. ⁶²	Bellanger AP...Reboux G	32779722	2020
9	[A case of farmer's lung associated with allergic bronchopulmonary aspergillosis]. ⁶²	Duprez M...Dalphin JC	31870516	2020
10	[ALLERGIC ALVEOLITIS [ARTICLE IN POLISH]]. ⁶²	Fal AM	33055317	2020
11	Characteristics of hypersensitivity pneumonitis diagnosed by interstitial and occupational lung disease multi-disciplinary team consensus. ⁶²	Walters GI...Burge PS	31295673	2019
12	Hypersensitivity pneumonitis: A new strategy for serodiagnosis and environmental surveys. ⁶²	Bellanger AP...Millon L	30961934	2019
13	Farmer's lung disease: Analysis of 75 cases. ⁶²	Cano-Jimenez E...Veres A	28587854	2017
14	Mold and Human Health: a Reality Check. ⁶²	Borchers AT...Eric Gershwin M	28299723	2017
15	Emphysema in active farmer's lung disease. ⁶²	Soumagne T...Dalphin JC	28614400	2017
16	High prevalence of obstructive lung disease in non-smoking farmers: The Irish farmers lung health study. ⁶²	Cushen B...O'Regan A	27215498	2016
17	Farmer's Lung Disease. A Review. ⁶²	Cano-Jimenez E...Sanjuan P	26874898	2016
18	Identification of Antigenic Proteins from Lichtheimia corymbifera for Farmer's Lung Disease Diagnosis. ⁶²	Rognon B...Millon L	27490813	2016
19	Combined pulmonary fibrosis and emphysema in hypersensitivity pneumonitis. ⁶²	Soumagne T...Dalphin JC	26689249	2015
20	Western blotting as a tool for the serodiagnosis of farmer's lung disease: validation with Lichtheimia corymbifera protein extracts. ⁶²	Rognon B...Millon L	25666836	2015
21	[Chronic Farmer's lung disease with emphysema]. ⁶²	Soumagne T...Dalphin JC	25847206	2015
22	Prevalence and risk factors for farmer's lung in greenhouse farmers: an epidemiological study of 5,880 farmers from Northeast China. ⁶²	Liu S...Wang X	25344645	2015
23	Cross-Shift Changes in Lung Function Among Palestinian Farmers During High- and Low-Exposure Periods to Pesticides: A Longitudinal Study. ⁶²	Sham'a FA...Kristensen P	25386741	2015
24	Immunoreactive proteins of Saccharopolyspora rectivirgula for farmer's lung serodiagnosis. ⁶²	Barrera C...Monod M	25264606	2014
25	Draft Genome Sequence of the Principal Etiological Agent of Farmer's Lung Disease, Saccharopolyspora rectivirgula. ⁶²	Barrera C...Millon L	25523783	2014
26	Draft Genome Sequence of Saccharopolyspora rectivirgula. ⁶²	Pettersson BM...Kirsebom LA	24407634	2014
27	Assessing the implications of contradictory farm exposure data in an aging rural population. ⁶²	Chapel D...Jenkins P	24959758	2014
28	[A case report of farmer's lung]. ⁶²	Xu H...Duan DJ	24370311	2013
29	Nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan. ⁶²	Okamoto T...Inase N	23978646	2013
30	Quantification of Saccharopolyspora rectivirgula in composting plants: assessment of the relevance of S. rectivirgula. ⁶²	Schafer J...Jackel U	23579625	2013
31	Defining syndromes using cattle meat inspection data for syndromic surveillance purposes: a statistical approach with the 2005-2010 data from ten French slaughterhouses. ⁶²	Dupuy C...Gay E	23628140	2013
32	[Domestic hypersensitivity pneumonitis]. ⁶²	Caillaud D...Horo K	23101639	2012
33	Aspergillus species recombinant antigens for serodiagnosis of farmer's lung disease. ⁶²	Millon L...Monod M	22608571	2012
34	[Farmer's lung antigens in Germany]. ⁶²	Sennekamp J...Raulf-Heimsoth M	22477566	2012
35	Characterization of bioaerosols from dairy barns: reconstructing the puzzle of occupational respiratory diseases by using molecular approaches. ⁶²	Blais Lecours P...Duchaine C	22367078	2012
36	Farmer's lung-induced hypersensitivity pneumonitis complicated by shock. ⁶²	Deschenes D...Cormier Y	22005584	2012
37	Bioaerosol exposure assessment in the workplace: the past, present and recent advances. ⁶²	Eduard W...Green BJ	22267210	2012
38	Bronchoalveolar lavage in hypersensitivity pneumonitis: a series of 139 patients. ⁶²	Caillaud DM...French Group of Environmental Immunoallergic Bronchopulmonary Diseases	22309080	2012
39	Farmer's lung in a case after bullectomy. ⁶²	Koschel D...Hoffken G	22398814	2012
40	Salt induces biosynthesis of hemolytically active compounds in the xerotolerant food-borne fungus Wallemia sebi. ⁶²	Botic T...Gunde-Cimerman N	22092533	2012
41	Pneumomediastinum as a primary manifestation of chronic hypersensitivity pneumonitis. ⁶²	Koschel D...Hoffken G	22129907	2011
42	Consequences of respiratory exposures in the farm environment. ⁶²	Langley RL	22523860	2011
43	Work-related lung diseases. ⁶²	Weston A	22997873	2011
44	[Chronic and acute hypersensitivity pneumonitis in a dairy farmer and his son]. ⁶²	Satoh M...Araya Y	21346406	2011
45	[Case of bird-related hypersensitivity pneumonitis in a farmer]. ⁶²	Ishiguro T...Sugita Y	21226310	2010
46	New evidence of the involvement of Lichtheimia corymbifera in farmer's lung disease. ⁶²	Bellanger AP...Millon L	20353311	2010
47	Genomics and the ancient origins of the daptomycin biosynthetic gene cluster. ⁶²	Baltz RH	20648020	2010
48	Protein kinase D1 is essential for the proinflammatory response induced by hypersensitivity pneumonitis-causing thermophilic actinomycetes Saccharopolyspora rectivirgula. ⁶²	Kim YI...Yi AK	20142359	2010
49	Excellent visual outcome following Aspergillus flavus endogenous endophthalmitis-farmer's lung disease. ⁶²	Bakri SJ...Gordon SM	19132296	2010
50	[Epidemiology of interstitial lung diseases]. ⁶²	Valeyre D...Nunes H	19962852	2010

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Genes for Farmer's Lung

Genes related to Farmer's Lung (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TNF	Tumor Necrosis Factor	Protein Coding	12.39	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	IL2	Interleukin 2	Protein Coding	11.7	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	ELANE	Elastase, Neutrophil Expressed	Protein Coding	10.86	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	PI3	Peptidase Inhibitor 3	Protein Coding	10.55	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	7.86	GeneCards inferred via : Publications (show sections)
6	CD36	CD36 Molecule	Protein Coding	7.67	GeneCards inferred via : Publications (show sections)
7	SLPI	Secretory Leukocyte Peptidase Inhibitor	Protein Coding	7.67	GeneCards inferred via : Publications (show sections)
8	SERPINA3	Serpin Family A Member 3	Protein Coding	5.9	DISEASES inferred ¹⁴ ¹⁴
9	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	5.84	DISEASES inferred ¹⁴ ¹⁴
10	CD4	CD4 Molecule	Protein Coding	5.63	DISEASES inferred ¹⁴
11	CHTOP	Chromatin Target Of PRMT1	Protein Coding	5.46	DISEASES inferred ¹⁴
12	CD8A	CD8a Molecule	Protein Coding	5.38	DISEASES inferred ¹⁴
13	CRIP3	Cysteine Rich Protein 3	Protein Coding	5.01	DISEASES inferred ¹⁴

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Variations for Farmer's Lung

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Expression for Farmer's Lung

Search GEO for disease gene expression data for Farmer's Lung.

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Pathways for Farmer's Lung

Pathways related to Farmer's Lung according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.51	TNF SLPI SERPINA3 PI3 IL2 ELANE
2	Defensins ⁶⁶ Show member pathways Alpha-defensins ⁶⁶ Antimicrobial peptides ⁶⁶ Beta defensins ⁶⁶ Ion influx/efflux at host-pathogen interface ⁶⁶ Metal sequestration by antimicrobial proteins ⁶⁶	12.02	PI3 ELANE CD4 CCR6
3	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.85	CD4 CD8A IL2 TNF
4	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.7	IL2 CD8A CD4
5	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.63	TNF IL2 CD4
6	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.5	IGHE CD8A CD4
7	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.42	TNF IL2 CD8A CD4 CD36
8	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.33	TNF IL2 CD8A CD4
9	THC Differentiation Pathway ⁶⁴	11.29	TNF IL2 CD4
10	Cytokines and inflammatory response ⁷⁴	10.96	TNF IL2 CD4
11	Innate Lymphoid Cells Differentiation ⁶⁵	10.92	TNF IL2 CD8A CD4 CCR6
12	Roles of ceramides in the development of insulin resistance ⁷⁴	10.88	TNF CD36
13	LDL Oxidation in Atherogenesis ⁶⁴	10.73	TNF CD36
14	Selective expression of chemokine receptors during T-cell polarization ⁷⁴	10.67	IL2 CD4

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GO Terms for Farmer's Lung

Cellular components related to Farmer's Lung according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.86	TNF SLPI SERPINA3 PI3 IL2 IGHE
2	external side of plasma membrane	GO:0009897	9.4	TNF IGHE CD8A CD4 CD36 CCR6

Biological processes related to Farmer's Lung according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response to bacterium	GO:0042742	9.85	TNF SLPI IGHE ELANE
2	immune system process	GO:0002376	9.72	SLPI IL2 IGHE CD8A CD4
3	immune response	GO:0006955	9.5	TNF SLPI IL2 IGHE CD8A CD4
4	positive regulation of blood microparticle formation	GO:2000334	9.46	TNF CD36
5	negative regulation of peptidase activity	GO:0010466	9.43	SLPI SERPINA3 PI3
6	leukocyte migration involved in inflammatory response	GO:0002523	9.43	TNF ELANE CCR6

Molecular functions related to Farmer's Lung according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidase inhibitor activity	GO:0030414	8.8	SLPI SERPINA3 PI3

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Sources for Farmer's Lung

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: FRM003 MIFTS: 41	Farmer's Lung Categories: Immune diseases, Rare diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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