MCID: FRM003
MIFTS: 41

Farmer's Lung

Categories: Immune diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Farmer's Lung

MalaCards integrated aliases for Farmer's Lung:

Name: Farmer's Lung 11 19 75 43 14 71
Farmer Lung 11 31 33
Farmers Lung 11 53
Harvesters' Hypersensitivity Pneumonitis 33
Haymakers' Hypersensitivity Pneumonitis 33
Fibrosis of Lung with Farmers' Lung 33
Moldy Hay Pneumoconiosis 33
Farmer's Lung Disease 58
Farmers' Lung Disease 33
Mouldy Hay Disease 33
Moldy Hay Disorder 33
Threshers' Lung 33
Harvester Lung 33
Farmers' Lung 33
Haymaker Lung 33

Classifications:

Orphanet: 58  
Rare respiratory diseases
Rare allergic disease


External Ids:

Disease Ontology 11 DOID:14453
ICD9CM 34 495.0
MeSH 43 D005203
NCIt 49 C34605
SNOMED-CT 68 155581001
ICD10 31 J67.0
MESH via Orphanet 44 D005203
ICD10 via Orphanet 32 J67.0
UMLS via Orphanet 72 C0015634
Orphanet 58 ORPHA99906
ICD11 33 666590509
UMLS 71 C0015634

Summaries for Farmer's Lung

GARD: 19 Farmer's lung disease is the main form of occupational hypersensitivity pneumonitis (see this term), caused by chronic inhalation of microorganisms, often thermophilic actinomycetes and less commonly saccharopolyspora rectivirgula, living in mouldy hay, straw, or grain. It is characterized by variable degrees of dyspnea, cough, tiredness, headaches and occasional fever/night sweats, with acute, sub-acute or chronic clinical course

MalaCards based summary: Farmer's Lung, also known as farmer lung, is related to interstitial lung disease and actinomycosis. An important gene associated with Farmer's Lung is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Defensins. Affiliated tissues include lung, skin and b cells, and related phenotypes are immune system and hematopoietic system

Orphanet: 58 Farmer's lung disease is the main form of occupational hypersensitivity pneumonitis (see this term), caused by chronic inhalation of microorganisms, often thermophilic actinomycetes and less commonly saccharopolyspora rectivirgula, living in mouldy hay, straw, or grain. It is characterized by variable degrees of dyspnea, cough, tiredness, headaches and occasional fever/night sweats, with acute, sub-acute or chronic clinical course

Disease Ontology: 11 An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

Wikipedia: 75 Farmer's lung (not to be confused with silo-filler's disease) is a hypersensitivity pneumonitis induced... more...

Related Diseases for Farmer's Lung

Diseases related to Farmer's Lung via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 584)
# Related Disease Score Top Affiliating Genes
1 interstitial lung disease 31.9 TNF SERPINA3 CCR6
2 actinomycosis 31.3 TNF CD4
3 aspergillosis 30.9 TNF SLPI ELANE CCR6
4 bronchitis 30.8 TNF SLPI IGHE ELANE
5 lung disease 30.8 TNF SLPI SERPINA3 PI3 ELANE CCR6
6 bird fancier's lung 30.3 CD8A CD4
7 proteasome-associated autoinflammatory syndrome 1 30.2 TNF IGHE ELANE
8 extrinsic allergic alveolitis 30.0 TNF PI3 IGHE ELANE CD8A CD4
9 ventilation pneumonitis 30.0 CD8A CD4
10 pulmonary emphysema 30.0 SLPI SERPINA3 ELANE
11 dermatitis 29.9 TNF IL2 IGHE CCR6
12 histoplasmosis 29.9 TNF CD4 CCR6
13 allergic bronchopulmonary aspergillosis 29.9 IGHE CD4 CCR6
14 hypersensitivity reaction type iii disease 29.6 TNF SERPINA3 CD4 CCR6
15 pneumonia 29.6 TNF SLPI ELANE CD8A
16 asthma 29.5 TNF SERPINA3 IL2 IGHE ELANE CD4
17 chronic granulomatous disease 29.5 TNF CD8A CD4
18 immunoglobulin alpha deficiency 29.5 CD8A CD4 CCR6
19 allergic disease 29.4 TNF SERPINA3 IL2 IGHE CD8A CD4
20 adult t-cell leukemia/lymphoma 29.3 IL2 CD8A CD4 CCR6
21 polyclonal hypergammaglobulinemia 29.2 SERPINA3 CD8A CD4 CCR6
22 t-cell acute lymphoblastic leukemia 29.2 IL2 CD8A CD4 CCR6
23 celiac disease 1 29.1 TNF SERPINA3 IL2 CD8A CD4 CCR6
24 fungal infectious disease 29.1 TNF IL2 CD8A CD4 CCR6
25 respiratory failure 29.1 TNF SERPINA3 IL2 IGHE ELANE CD8A
26 sarcoidosis 1 28.8 TNF SERPINA3 IL2 CD8A CD4 CCR6
27 dermatitis, atopic 28.6 TNF SERPINA3 IL2 IGHE CD8A CD4
28 interstitial lung disease 2 28.5 TNF SERPINA3 IL2 ELANE CD8A CD4
29 ceroid lipofuscinosis, neuronal, 5 10.5
30 pulmonary fibrosis 10.4
31 acute graft versus host disease 10.3 TNF IL2
32 nut allergy 10.2 IGHE CCR6
33 arthrogryposis, renal dysfunction, and cholestasis 1 10.2
34 corneal abscess 10.2 SLPI PI3
35 conjunctivitis 10.2 TNF IL2 IGHE
36 intestinal tuberculosis 10.2 TNF CD4
37 aspiration pneumonitis 10.2 TNF SERPINA3
38 schistosomiasis 10.2 TNF IL2 IGHE
39 elephantiasis 10.2 ELANE CD4
40 clonorchiasis 10.2 TNF IL2 IGHE
41 sapho syndrome 10.2 TNF CCR6
42 pericardial tuberculosis 10.2 TNF CD4
43 funisitis 10.2 TNF CCR6
44 transient arthritis 10.2 TNF CD4
45 optic papillitis 10.2 TNF CD4
46 exocrine pancreatic insufficiency 10.2 TNF IGHE ELANE
47 lymph node tuberculosis 10.2 TNF CD4
48 toxic megacolon 10.2 TNF CCR6
49 nocardiosis 10.2 TNF CD4
50 arachnoiditis 10.2 TNF CD4

Comorbidity relations with Farmer's Lung via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to Farmer's Lung

Symptoms & Phenotypes for Farmer's Lung

MGI Mouse Phenotypes related to Farmer's Lung:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.73 CCR6 CD36 CD4 CD8A CHTOP CRIP3
2 hematopoietic system MP:0005397 9.4 CCR6 CD36 CD4 CD8A CHTOP CRIP3

Drugs & Therapeutics for Farmer's Lung

Search Clinical Trials, NIH Clinical Center for Farmer's Lung

Cochrane evidence based reviews: farmer's lung

Genetic Tests for Farmer's Lung

Anatomical Context for Farmer's Lung

Organs/tissues related to Farmer's Lung:

MalaCards : Lung, Skin, B Cells, T Cells, Neutrophil, Pituitary

Publications for Farmer's Lung

Articles related to Farmer's Lung:

(show top 50) (show all 766)
# Title Authors PMID Year
1
[Relationship between severity of farmer's lung and the level of soluble interleukin 2 receptors in serum]. 53 62
8937141 1996
2
[A study on interleukin 2 and soluble interleukin 2 receptor in serum and bronchoalveolar lavage fluid from patients with farmer's lung]. 53 62
1770680 1991
3
Prevalence and Risk Factors for Pulmonary Conditions among Farmers and Ranchers in the Central United States. 62
35026966 2022
4
Antigen avoidance and environmental inhalation challenge for successful diagnosis of fibrotic hypersensitivity pneumonitis mimicking idiopathic pulmonary fibrosis. 62
36133420 2022
5
[Hypersensitivity Pneumonitis: An update]. 62
33941410 2021
6
Occupational lung disease: A narrative review of lung conditions from the workplace. 62
33854771 2021
7
Sooty bark disease of maples: the risk for hypersensitivity pneumonitis by fungal spores not only for woodman. 62
33478566 2021
8
Studying smoking benefit in farmer's lung to understand Covid-19. 62
32779722 2020
9
[A case of farmer's lung associated with allergic bronchopulmonary aspergillosis]. 62
31870516 2020
10
[ALLERGIC ALVEOLITIS [ARTICLE IN POLISH]]. 62
33055317 2020
11
Characteristics of hypersensitivity pneumonitis diagnosed by interstitial and occupational lung disease multi-disciplinary team consensus. 62
31295673 2019
12
Hypersensitivity pneumonitis: A new strategy for serodiagnosis and environmental surveys. 62
30961934 2019
13
Farmer's lung disease: Analysis of 75 cases. 62
28587854 2017
14
Mold and Human Health: a Reality Check. 62
28299723 2017
15
Emphysema in active farmer's lung disease. 62
28614400 2017
16
High prevalence of obstructive lung disease in non-smoking farmers: The Irish farmers lung health study. 62
27215498 2016
17
Farmer's Lung Disease. A Review. 62
26874898 2016
18
Identification of Antigenic Proteins from Lichtheimia corymbifera for Farmer's Lung Disease Diagnosis. 62
27490813 2016
19
Combined pulmonary fibrosis and emphysema in hypersensitivity pneumonitis. 62
26689249 2015
20
Western blotting as a tool for the serodiagnosis of farmer's lung disease: validation with Lichtheimia corymbifera protein extracts. 62
25666836 2015
21
[Chronic Farmer's lung disease with emphysema]. 62
25847206 2015
22
Prevalence and risk factors for farmer's lung in greenhouse farmers: an epidemiological study of 5,880 farmers from Northeast China. 62
25344645 2015
23
Cross-Shift Changes in Lung Function Among Palestinian Farmers During High- and Low-Exposure Periods to Pesticides: A Longitudinal Study. 62
25386741 2015
24
Immunoreactive proteins of Saccharopolyspora rectivirgula for farmer's lung serodiagnosis. 62
25264606 2014
25
Draft Genome Sequence of the Principal Etiological Agent of Farmer's Lung Disease, Saccharopolyspora rectivirgula. 62
25523783 2014
26
Draft Genome Sequence of Saccharopolyspora rectivirgula. 62
24407634 2014
27
Assessing the implications of contradictory farm exposure data in an aging rural population. 62
24959758 2014
28
[A case report of farmer's lung]. 62
24370311 2013
29
Nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan. 62
23978646 2013
30
Quantification of Saccharopolyspora rectivirgula in composting plants: assessment of the relevance of S. rectivirgula. 62
23579625 2013
31
Defining syndromes using cattle meat inspection data for syndromic surveillance purposes: a statistical approach with the 2005-2010 data from ten French slaughterhouses. 62
23628140 2013
32
[Domestic hypersensitivity pneumonitis]. 62
23101639 2012
33
Aspergillus species recombinant antigens for serodiagnosis of farmer's lung disease. 62
22608571 2012
34
[Farmer's lung antigens in Germany]. 62
22477566 2012
35
Characterization of bioaerosols from dairy barns: reconstructing the puzzle of occupational respiratory diseases by using molecular approaches. 62
22367078 2012
36
Farmer's lung-induced hypersensitivity pneumonitis complicated by shock. 62
22005584 2012
37
Bioaerosol exposure assessment in the workplace: the past, present and recent advances. 62
22267210 2012
38
Bronchoalveolar lavage in hypersensitivity pneumonitis: a series of 139 patients. 62
22309080 2012
39
Farmer's lung in a case after bullectomy. 62
22398814 2012
40
Salt induces biosynthesis of hemolytically active compounds in the xerotolerant food-borne fungus Wallemia sebi. 62
22092533 2012
41
Pneumomediastinum as a primary manifestation of chronic hypersensitivity pneumonitis. 62
22129907 2011
42
Consequences of respiratory exposures in the farm environment. 62
22523860 2011
43
Work-related lung diseases. 62
22997873 2011
44
[Chronic and acute hypersensitivity pneumonitis in a dairy farmer and his son]. 62
21346406 2011
45
[Case of bird-related hypersensitivity pneumonitis in a farmer]. 62
21226310 2010
46
New evidence of the involvement of Lichtheimia corymbifera in farmer's lung disease. 62
20353311 2010
47
Genomics and the ancient origins of the daptomycin biosynthetic gene cluster. 62
20648020 2010
48
Protein kinase D1 is essential for the proinflammatory response induced by hypersensitivity pneumonitis-causing thermophilic actinomycetes Saccharopolyspora rectivirgula. 62
20142359 2010
49
Excellent visual outcome following Aspergillus flavus endogenous endophthalmitis-farmer's lung disease. 62
19132296 2010
50
[Epidemiology of interstitial lung diseases]. 62
19962852 2010

Variations for Farmer's Lung

Expression for Farmer's Lung

Search GEO for disease gene expression data for Farmer's Lung.

Pathways for Farmer's Lung

Pathways related to Farmer's Lung according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 TNF SLPI SERPINA3 PI3 IL2 ELANE
2
Show member pathways
12.02 PI3 ELANE CD4 CCR6
3
Show member pathways
11.85 CD4 CD8A IL2 TNF
4
Show member pathways
11.7 IL2 CD8A CD4
5
Show member pathways
11.63 TNF IL2 CD4
6
Show member pathways
11.5 IGHE CD8A CD4
7 11.42 TNF IL2 CD8A CD4 CD36
8 11.33 TNF IL2 CD8A CD4
9 11.29 TNF IL2 CD4
10 10.96 TNF IL2 CD4
11 10.92 TNF IL2 CD8A CD4 CCR6
12 10.88 TNF CD36
13 10.73 TNF CD36
14 10.67 IL2 CD4

GO Terms for Farmer's Lung

Cellular components related to Farmer's Lung according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 TNF SLPI SERPINA3 PI3 IL2 IGHE
2 external side of plasma membrane GO:0009897 9.4 TNF IGHE CD8A CD4 CD36 CCR6

Biological processes related to Farmer's Lung according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.85 TNF SLPI IGHE ELANE
2 immune system process GO:0002376 9.72 SLPI IL2 IGHE CD8A CD4
3 immune response GO:0006955 9.5 TNF SLPI IL2 IGHE CD8A CD4
4 positive regulation of blood microparticle formation GO:2000334 9.46 TNF CD36
5 negative regulation of peptidase activity GO:0010466 9.43 SLPI SERPINA3 PI3
6 leukocyte migration involved in inflammatory response GO:0002523 9.43 TNF ELANE CCR6

Molecular functions related to Farmer's Lung according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase inhibitor activity GO:0030414 8.8 SLPI SERPINA3 PI3

Sources for Farmer's Lung

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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