MCID: FRM003
MIFTS: 41

Farmer's Lung

Categories: Rare diseases, Respiratory diseases, Immune diseases

Aliases & Classifications for Farmer's Lung

MalaCards integrated aliases for Farmer's Lung:

Name: Farmer's Lung 12 76 53 44 15 73
Farmers Lung 12 55
Farmer's Lung Disease 59
Farmer Lung 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14453
ICD10 33 J67.0
ICD9CM 35 495.0
MeSH 44 D005203
NCIt 50 C34605
Orphanet 59 ORPHA99906
MESH via Orphanet 45 D005203
ICD10 via Orphanet 34 J67.0
UMLS via Orphanet 74 C0015634
UMLS 73 C0015634

Summaries for Farmer's Lung

Disease Ontology : 12 An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

MalaCards based summary : Farmer's Lung, also known as farmers lung, is related to extrinsic allergic alveolitis and lung disease. An important gene associated with Farmer's Lung is IL2 (Interleukin 2), and among its related pathways/superpathways are Innate Immune System and Developmental Biology. Affiliated tissues include lung, testes and skin, and related phenotype is neoplasm.

Wikipedia : 76 Farmer\'s lung (not to be confused with silo-filler\'s disease) is a hypersensitivity pneumonitis... more...

Related Diseases for Farmer's Lung

Diseases related to Farmer's Lung via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 extrinsic allergic alveolitis 29.4 CD79A PI3
2 lung disease 29.2 ELANE PI3 TNF
3 balanoposthitis 10.6 IL2 PI3
4 oral tuberculosis 10.6 IL2 TNF
5 autoimmune myocarditis 10.6 IL2 TNF
6 streptococcal toxic-shock syndrome 10.6 IL2 TNF
7 crohn's colitis 10.5 IL2 TNF
8 burning mouth syndrome 10.5 IL2 TNF
9 posterior uveitis 10.5 IL2 TNF
10 intermediate uveitis 10.5 IL2 TNF
11 irritant dermatitis 10.5 PI3 TNF
12 hematopoietic stem cell transplantation 10.5 IL2 TNF
13 progressive multifocal leukoencephalopathy 10.5 IL2 TNF
14 lepromatous leprosy 10.5 IL2 TNF
15 rheumatic fever 10.5 IL2 TNF
16 acute graft versus host disease 10.5 IL2 TNF
17 pleurisy 10.4 IL2 TNF
18 prostatitis 10.4 IL2 TNF
19 paracoccidioidomycosis 10.4 IL2 TNF
20 brucellosis 10.4 IL2 TNF
21 mumps 10.4 IL2 TNF
22 spondyloarthropathy 10.4 IL2 TNF
23 smallpox 10.4 IL2 TNF
24 capillary leak syndrome 10.3 ELANE IL2
25 filariasis 10.3 IL2 TNF
26 pasteurellosis 10.3 ELANE PI3
27 impetigo 10.3 ELANE PI3
28 impetigo herpetiformis 10.3 ELANE PI3
29 pulmonary sarcoidosis 10.3 IL2 TNF
30 arthus reaction 10.2 ELANE TNF
31 netherton syndrome 10.1 ELANE PI3
32 trichomoniasis 10.1 CD79A IL2
33 cervicitis 10.1 CD79A IL2
34 toxic shock syndrome 10.1 IL2 TNF
35 vulvovaginal candidiasis 10.1 CD79A IL2
36 adult respiratory distress syndrome 10.0 ELANE TNF
37 chorioamnionitis 10.0 ELANE TNF
38 vernal conjunctivitis 10.0 CD79A IL2
39 osteosclerotic myeloma 10.0 CD79A TNF
40 jejunoileitis 10.0 CD79A TNF
41 acute salpingitis 10.0 CD79A TNF
42 monoclonal gammopathy of uncertain significance 10.0 CD79A TNF
43 orofacial granulomatosis 10.0 CD79A TNF
44 pneumocystosis 10.0 CD79A TNF
45 chronic salpingitis 10.0 CD79A TNF
46 lichen disease 10.0 CD79A TNF
47 chronic fatigue syndrome 10.0 IL2 TNF
48 middle ear disease 10.0 CD79A TNF
49 q fever 9.9 CD79A TNF
50 geographic tongue 9.9 CD79A TNF

Comorbidity relations with Farmer's Lung via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to Farmer's Lung

Symptoms & Phenotypes for Farmer's Lung

MGI Mouse Phenotypes related to Farmer's Lung:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 CD79A ELANE IL2 TNF

Drugs & Therapeutics for Farmer's Lung

Search Clinical Trials , NIH Clinical Center for Farmer's Lung

Cochrane evidence based reviews: farmer's lung

Genetic Tests for Farmer's Lung

Anatomical Context for Farmer's Lung

MalaCards organs/tissues related to Farmer's Lung:

41
Lung, Testes, Skin, Neutrophil, B Cells

Publications for Farmer's Lung

Articles related to Farmer's Lung:

(show top 50) (show all 339)
# Title Authors Year
1
Farmer's lung disease: Analysis of 75 cases. ( 28587854 )
2017
2
Emphysema in active farmer's lung disease. ( 28614400 )
2017
3
Farmer's Lung Disease. A Review. ( 26874898 )
2016
4
Identification of Antigenic Proteins from Lichtheimia corymbifera for Farmer's Lung Disease Diagnosis. ( 27490813 )
2016
5
Western blotting as a tool for the serodiagnosis of farmer's lung disease: validation with Lichtheimia corymbifera protein extracts. ( 25666836 )
2015
6
Draft Genome Sequence of the Principal Etiological Agent of Farmer's Lung Disease, Saccharopolyspora rectivirgula. ( 25523783 )
2014
7
Immunoreactive proteins of Saccharopolyspora rectivirgula for farmer's lung serodiagnosis. ( 25264606 )
2014
8
Prevalence and Risk Factors for Farmer's Lung in Greenhouse Farmers: An Epidemiological Study of 5,880 Farmers from Northeast China. ( 25344645 )
2014
9
Farmer's lung in a case after bullectomy. ( 22398814 )
2012
10
Aspergillus species recombinant antigens for serodiagnosis of farmer's lung disease. ( 22608571 )
2012
11
Farmer's lung-induced hypersensitivity pneumonitis complicated by shock. ( 22005584 )
2012
12
Excellent visual outcome following Aspergillus flavus endogenous endophthalmitis-farmer's lung disease. ( 19132296 )
2010
13
New evidence of the involvement of Lichtheimia corymbifera in farmer's lung disease. ( 20353311 )
2010
14
Comparison of three antigenic extracts of Eurotium amstelodami in serological diagnosis of farmer's lung disease. ( 19906892 )
2010
15
Multilevel analysis of the impact of environmental factors and agricultural practices on the concentration in hay of microorganisms responsible for farmer's lung disease. ( 20047254 )
2009
16
Elevated levels of beta-D-glucan in bronchoalveolar lavage fluid in patients with farmer's lung in Miyazaki, Japan. ( 17202807 )
2008
17
Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study. ( 17182642 )
2007
18
Farmer's lung is now in decline. ( 16986564 )
2006
19
Farmer's lung disease and microbiological composition of hay: a case-control study. ( 16244894 )
2005
20
Evaluation of salting as a hay preservative against farmer's lung disease agents. ( 16457476 )
2005
21
Microbiological evolution of hay and relapse in patients with farmer's lung. ( 14691284 )
2004
22
Farmer's lung. ( 15529581 )
2003
23
Long-term sequelae of Farmer's lung disease in HRCT: a 14-year follow-up study of 88 patients and 83 matched control farmers. ( 12928967 )
2003
24
Occurrence of farmer's lung disease is relevant to meteorological conditions: a 20-year follow-up field survey analysis. ( 12173376 )
2002
25
The risk of asthma among Finnish patients with farmer's lung. ( 12373322 )
2002
26
Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients. ( 11179110 )
2001
27
Role of molds in farmer's lung disease in Eastern France. ( 11401869 )
2001
28
Pulmonary glutathione levels in acute episodes of Farmer's lung. ( 10852775 )
2000
29
High-resolution computed tomographic characteristics in acute farmer's lung and in its follow-up. ( 10933085 )
2000
30
Farmer's lung in Ireland (1983-1996) remains at a constant level. ( 10098338 )
1999
31
IgG antibodies, chronic bronchitis, and pulmonary function values in farmer's lung patients and matched controls. ( 10604554 )
1999
32
Saccharopolyspora rectivirgula from Quebec dairy barns: application of simplified criteria for the identification of an agent responsible for farmer's lung disease. ( 9989646 )
1999
33
Long-term risk of emphysema in patients with farmer's lung and matched control farmers. ( 9700147 )
1998
34
Role of interleukin-2 in the development and persistence of lymphocytic alveolitis in farmer's lung. ( 9657567 )
1998
35
IgE antibody response against Aspergillus umbrosus in farmer's lung disease. ( 9066519 )
1997
36
Diagnostic accuracy of transbronchial biopsy in acute farmer's lung disease. ( 9404739 )
1997
37
Cardiopulmonary exercise testing following hay exposure challenge in farmer's lung. ( 9387965 )
1997
38
Asthma in patients with farmer's lung during a five-year follow-up. ( 9167238 )
1997
39
Long-term outcome of pulmonary function in farmer's lung: a 14 year follow-up with matched controls. ( 9311500 )
1997
40
Fatal cases of farmer's lung in a Canadian family. Probable new antigens, Penicillium brevicompactum and P olivicolor. ( 8996026 )
1997
41
Effect of contact avoidance or treatment with oral prednisolone on bronchoalveolar lavage surfactant protein A levels in subjects with farmer's lung. ( 8994517 )
1996
42
Viral infection enhances the response to Saccharopolyspora rectivirgula in mice prechallenged with this farmer's lung antigen. ( 8887935 )
1996
43
[Relationship between severity of farmer's lung and the level of soluble interleukin 2 receptors in serum]. ( 8937141 )
1996
44
Farmer's lung: patients' IgG2 antibodies specifically recognize Saccharopolyspora rectivirgula proteins and carbohydrate structures. ( 8757222 )
1996
45
Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung. ( 8887613 )
1996
46
Identification of the reactive subunits of Aspergillus umbrosus involved in the antigenic response in farmer's lung. ( 8809426 )
1996
47
Smoking promotes insidious and chronic farmer's lung disease, and deteriorates the clinical outcome. ( 8563097 )
1995
48
Farmer's lung and variables related to the decision to quit farming. ( 7663816 )
1995
49
Detection of specific antibodies in immune complexes of farmer's lung patients. ( 8705008 )
1995
50
Mast cell and histamine involvement in farmer's lung disease. ( 8162747 )
1994

Variations for Farmer's Lung

Expression for Farmer's Lung

Search GEO for disease gene expression data for Farmer's Lung.

Pathways for Farmer's Lung

GO Terms for Farmer's Lung

Cellular components related to Farmer's Lung according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD36 CD79A TNF
2 membrane raft GO:0045121 8.8 CD36 CD79A TNF

Biological processes related to Farmer's Lung according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.58 CD36 IL2 TNF
2 positive regulation of MAP kinase activity GO:0043406 9.49 ELANE TNF
3 positive regulation of smooth muscle cell proliferation GO:0048661 9.48 ELANE TNF
4 antimicrobial humoral response GO:0019730 9.46 ELANE PI3
5 positive regulation of interleukin-6 production GO:0032755 9.43 CD36 TNF
6 MAPK cascade GO:0000165 9.43 IL2 PSMA1 TNF
7 positive regulation of interferon-gamma production GO:0032729 9.37 IL2 TNF
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.32 CD36 TNF
9 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.16 ELANE TNF
10 positive regulation of blood microparticle formation GO:2000334 8.96 CD36 TNF
11 negative regulation of growth of symbiont in host GO:0044130 8.8 CD36 ELANE TNF

Sources for Farmer's Lung

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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