MCID: FRM003
MIFTS: 40

Farmer's Lung

Categories: Immune diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Farmer's Lung

MalaCards integrated aliases for Farmer's Lung:

Name: Farmer's Lung 12 76 53 44 15 73
Farmers Lung 12 55
Farmer's Lung Disease 59
Farmer Lung 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14453
ICD10 33 J67.0
ICD9CM 35 495.0
MeSH 44 D005203
NCIt 50 C34605
SNOMED-CT 68 18690003
Orphanet 59 ORPHA99906
MESH via Orphanet 45 D005203
ICD10 via Orphanet 34 J67.0
UMLS via Orphanet 74 C0015634
UMLS 73 C0015634

Summaries for Farmer's Lung

Disease Ontology : 12 An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

MalaCards based summary : Farmer's Lung, also known as farmers lung, is related to lung disease and murray valley encephalitis. An important gene associated with Farmer's Lung is IL2 (Interleukin 2), and among its related pathways/superpathways are Innate Immune System and Developmental Biology. Affiliated tissues include lung, testes and skin.

Wikipedia : 76 Farmer''s lung (not to be confused with silo-filler''s disease) is a hypersensitivity pneumonitis... more...

Related Diseases for Farmer's Lung

Diseases related to Farmer's Lung via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 lung disease 30.2 ELANE PI3 TNF
2 murray valley encephalitis 10.2 IL2 PI3
3 balanoposthitis 10.2 IL2 PI3
4 oral tuberculosis 10.2 IL2 TNF
5 streptococcal toxic-shock syndrome 10.2 IL2 TNF
6 clonorchiasis 10.2 IL2 TNF
7 microscopic colitis 10.2 IL2 TNF
8 crohn's colitis 10.2 IL2 TNF
9 autoimmune gastritis 10.2 IL2 TNF
10 burning mouth syndrome 10.2 IL2 TNF
11 intermediate uveitis 10.2 IL2 TNF
12 posterior uveitis 10.2 IL2 TNF
13 trichuriasis 10.2 PI3 TNF
14 erythema multiforme 10.2 IL2 TNF
15 coccidiosis 10.2 IL2 TNF
16 hematopoietic stem cell transplantation 10.2 IL2 TNF
17 irritant dermatitis 10.1 PI3 TNF
18 progressive multifocal leukoencephalopathy 10.1 IL2 TNF
19 commensal bacterial infectious disease 10.1 IL2 TNF
20 lymphangiosarcoma 10.1 IL2 TNF
21 hypersensitivity reaction type iv disease 10.1 IL2 TNF
22 aphthous stomatitis 10.1 IL2 TNF
23 acute graft versus host disease 10.1 IL2 TNF
24 exanthem 10.1 IL2 TNF
25 rheumatic fever 10.1 IL2 TNF
26 lepromatous leprosy 10.1 IL2 TNF
27 prostatitis 10.1 IL2 TNF
28 autoimmune uveitis 10.1 IL2 TNF
29 paracoccidioidomycosis 10.1 IL2 TNF
30 testicular disease 10.1 IL2 TNF
31 pleurisy 10.1 IL2 TNF
32 lymphatic system disease 10.1 IL2 TNF
33 parasitic helminthiasis infectious disease 10.1 IL2 TNF
34 brucellosis 10.1 IL2 TNF
35 human immunodeficiency virus infectious disease 10.1 IL2 TNF
36 tonsillitis 10.1 IL2 TNF
37 smallpox 10.1 IL2 TNF
38 mumps 10.1 IL2 TNF
39 parasitic protozoa infectious disease 10.1 IL2 TNF
40 chronic graft versus host disease 10.1 CD36 TNF
41 leprosy 3 10.1 IL2 TNF
42 filariasis 10.1 IL2 TNF
43 autoimmune vasculitis 10.1 ELANE IL2
44 keratoconjunctivitis 10.1 IL2 TNF
45 autoimmune disease of musculoskeletal system 10.1 IL2 TNF
46 pulmonary sarcoidosis 10.1 IL2 TNF
47 pneumocystosis 10.1 FLNC TNF
48 alveolar echinococcosis 10.1 CD36 TNF
49 capillary leak syndrome 10.1 ELANE IL2
50 autoimmune disease of central nervous system 10.1 IL2 TNF

Comorbidity relations with Farmer's Lung via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to Farmer's Lung

Symptoms & Phenotypes for Farmer's Lung

Drugs & Therapeutics for Farmer's Lung

Search Clinical Trials , NIH Clinical Center for Farmer's Lung

Cochrane evidence based reviews: farmer's lung

Genetic Tests for Farmer's Lung

Anatomical Context for Farmer's Lung

MalaCards organs/tissues related to Farmer's Lung:

41
Lung, Testes, Skin, B Cells, Bone, Tonsil, Prostate

Publications for Farmer's Lung

Articles related to Farmer's Lung:

(show top 50) (show all 362)
# Title Authors Year
1
Farmer's lung disease: Analysis of 75 cases. ( 28587854 )
2017
2
Emphysema in active farmer's lung disease. ( 28614400 )
2017
3
Farmer's Lung Disease. A Review. ( 26874898 )
2016
4
Identification of Antigenic Proteins from Lichtheimia corymbifera for Farmer's Lung Disease Diagnosis. ( 27490813 )
2016
5
Western blotting as a tool for the serodiagnosis of farmer's lung disease: validation with Lichtheimia corymbifera protein extracts. ( 25666836 )
2015
6
Draft Genome Sequence of the Principal Etiological Agent of Farmer's Lung Disease, Saccharopolyspora rectivirgula. ( 25523783 )
2014
7
Immunoreactive proteins of Saccharopolyspora rectivirgula for farmer's lung serodiagnosis. ( 25264606 )
2014
8
Prevalence and Risk Factors for Farmer's Lung in Greenhouse Farmers: An Epidemiological Study of 5,880 Farmers from Northeast China. ( 25344645 )
2014
9
Farmer's lung in a case after bullectomy. ( 22398814 )
2012
10
Farmer's lung-induced hypersensitivity pneumonitis complicated by shock. ( 22005584 )
2012
11
Aspergillus species recombinant antigens for serodiagnosis of farmer's lung disease. ( 22608571 )
2012
12
Excellent visual outcome following Aspergillus flavus endogenous endophthalmitis-farmer's lung disease. ( 19132296 )
2010
13
New evidence of the involvement of Lichtheimia corymbifera in farmer's lung disease. ( 20353311 )
2010
14
Comparison of three antigenic extracts of Eurotium amstelodami in serological diagnosis of farmer's lung disease. ( 19906892 )
2010
15
Multilevel analysis of the impact of environmental factors and agricultural practices on the concentration in hay of microorganisms responsible for farmer's lung disease. ( 20047254 )
2009
16
Elevated levels of beta-D-glucan in bronchoalveolar lavage fluid in patients with farmer's lung in Miyazaki, Japan. ( 17202807 )
2008
17
Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study. ( 17182642 )
2007
18
Assessment of four serological techniques in the immunological diagnosis of farmers' lung disease. ( 17893167 )
2007
19
Farmer's lung is now in decline. ( 16986564 )
2006
20
Farmer's lung disease and microbiological composition of hay: a case-control study. ( 16244894 )
2005
21
Evaluation of salting as a hay preservative against farmer's lung disease agents. ( 16457476 )
2005
22
Microbiological evolution of hay and relapse in patients with farmer's lung. ( 14691284 )
2004
23
Farmer's lung. ( 15529581 )
2003
24
Long-term sequelae of Farmer's lung disease in HRCT: a 14-year follow-up study of 88 patients and 83 matched control farmers. ( 12928967 )
2003
25
Occurrence of farmer's lung disease is relevant to meteorological conditions: a 20-year follow-up field survey analysis. ( 12173376 )
2002
26
The risk of asthma among Finnish patients with farmer's lung. ( 12373322 )
2002
27
Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients. ( 11179110 )
2001
28
Role of molds in farmer's lung disease in Eastern France. ( 11401869 )
2001
29
Pulmonary glutathione levels in acute episodes of Farmer's lung. ( 10852775 )
2000
30
High-resolution computed tomographic characteristics in acute farmer's lung and in its follow-up. ( 10933085 )
2000
31
Farmer's lung in Ireland (1983-1996) remains at a constant level. ( 10098338 )
1999
32
IgG antibodies, chronic bronchitis, and pulmonary function values in farmer's lung patients and matched controls. ( 10604554 )
1999
33
Saccharopolyspora rectivirgula from Quebec dairy barns: application of simplified criteria for the identification of an agent responsible for farmer's lung disease. ( 9989646 )
1999
34
Long-term risk of emphysema in patients with farmer's lung and matched control farmers. ( 9700147 )
1998
35
Role of interleukin-2 in the development and persistence of lymphocytic alveolitis in farmer's lung. ( 9657567 )
1998
36
IgE antibody response against Aspergillus umbrosus in farmer's lung disease. ( 9066519 )
1997
37
Diagnostic accuracy of transbronchial biopsy in acute farmer's lung disease. ( 9404739 )
1997
38
Cardiopulmonary exercise testing following hay exposure challenge in farmer's lung. ( 9387965 )
1997
39
Asthma in patients with farmer's lung during a five-year follow-up. ( 9167238 )
1997
40
Long-term outcome of pulmonary function in farmer's lung: a 14 year follow-up with matched controls. ( 9311500 )
1997
41
Fatal cases of farmer's lung in a Canadian family. Probable new antigens, Penicillium brevicompactum and P olivicolor. ( 8996026 )
1997
42
Effect of contact avoidance or treatment with oral prednisolone on bronchoalveolar lavage surfactant protein A levels in subjects with farmer's lung. ( 8994517 )
1996
43
Viral infection enhances the response to Saccharopolyspora rectivirgula in mice prechallenged with this farmer's lung antigen. ( 8887935 )
1996
44
[Relationship between severity of farmer's lung and the level of soluble interleukin 2 receptors in serum]. ( 8937141 )
1996
45
Farmer's lung: patients' IgG2 antibodies specifically recognize Saccharopolyspora rectivirgula proteins and carbohydrate structures. ( 8757222 )
1996
46
Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung. ( 8887613 )
1996
47
Identification of the reactive subunits of Aspergillus umbrosus involved in the antigenic response in farmer's lung. ( 8809426 )
1996
48
Altered immunosuppressive activity of alveolar macrophages in farmer's lung disease. ( 8836659 )
1996
49
Smoking promotes insidious and chronic farmer's lung disease, and deteriorates the clinical outcome. ( 8563097 )
1995
50
Farmer's lung and variables related to the decision to quit farming. ( 7663816 )
1995

Variations for Farmer's Lung

Expression for Farmer's Lung

Search GEO for disease gene expression data for Farmer's Lung.

Pathways for Farmer's Lung

GO Terms for Farmer's Lung

Biological processes related to Farmer's Lung according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAP kinase activity GO:0043406 9.48 ELANE TNF
2 positive regulation of interleukin-6 production GO:0032755 9.46 CD36 TNF
3 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 ELANE TNF
4 cytokine-mediated signaling pathway GO:0019221 9.43 CD36 IL2 TNF
5 antimicrobial humoral response GO:0019730 9.4 ELANE PI3
6 positive regulation of interferon-gamma production GO:0032729 9.37 IL2 TNF
7 positive regulation of nitric oxide biosynthetic process GO:0045429 9.32 CD36 TNF
8 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.16 ELANE TNF
9 positive regulation of blood microparticle formation GO:2000334 8.96 CD36 TNF
10 negative regulation of growth of symbiont in host GO:0044130 8.8 CD36 ELANE TNF

Sources for Farmer's Lung

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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