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MCID: FRM003
MIFTS: 41

Farmer's Lung

Categories: Immune diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Farmer's Lung

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MalaCards integrated aliases for Farmer's Lung:

Name: Farmer's Lung 12 73 20 44 15 70
Farmers Lung 12 54
Farmer Lung 12 32
Farmer's Lung Disease 58

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare respiratory diseases
Rare allergic disease


External Ids:

Disease Ontology 12 DOID:14453
ICD9CM 34 495.0
MeSH 44 D005203
NCIt 50 C34605
SNOMED-CT 67 155581001
ICD10 32 J67.0
MESH via Orphanet 45 D005203
ICD10 via Orphanet 33 J67.0
UMLS via Orphanet 71 C0015634
Orphanet 58 ORPHA99906
UMLS 70 C0015634
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Summaries for Farmer's Lung

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Disease Ontology : 12 An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

MalaCards based summary : Farmer's Lung, also known as farmers lung, is related to extrinsic allergic alveolitis and bronchitis. An important gene associated with Farmer's Lung is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include lung, skin and t cells, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Wikipedia : 73 Farmer's lung (not to be confused with silo-filler's disease) is a hypersensitivity pneumonitis induced... more...

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Related Diseases for Farmer's Lung

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Diseases related to Farmer's Lung via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 466)
# Related Disease Score Top Affiliating Genes
1 extrinsic allergic alveolitis 32.1 PI3 IGHE ELANE
2 bronchitis 31.0 TNF SLPI ELANE
3 allergic disease 30.7 TNF IL2 IGHE
4 bird fancier's lung 30.3 CD8A CD4
5 lung disease 30.1 TNF SLPI SERPINA3 PI3 IL17A ELANE
6 polyclonal hypergammaglobulinemia 30.0 SERPINA3 CD4
7 ventilation pneumonitis 30.0 CD8A CD4
8 pulmonary emphysema 30.0 SLPI SERPINA3 ELANE
9 rhinitis 29.9 TNF IL17A IGHE
10 proteasome-associated autoinflammatory syndrome 1 29.8 TNF IL17A IGHE ELANE
11 chronic granulomatous disease 29.7 TNF SLPI IL17A ELANE
12 respiratory failure 29.4 TNF SERPINA3 ELANE CD8A CD4
13 sarcoidosis 1 29.2 TNF SERPINA3 IL2 CD8A CD4
14 dermatitis 28.9 TNF IL2 IL17A IGHE CD8A CD4
15 asthma 28.7 TNF SERPINA3 IL2 IL17A IGHE ELANE
16 dermatitis, atopic 28.5 TNF SERPINA3 IL2 IL17A IGHE CD8A
17 interstitial lung disease 11.1
18 pulmonary fibrosis 10.4
19 streptococcal toxic-shock syndrome 10.4 TNF IL2
20 aspergillosis 10.3
21 staphylococcal toxic shock syndrome 10.3 TNF IGHE
22 cardiac rupture 10.3 TNF ELANE
23 impetigo herpetiformis 10.3 PI3 ELANE
24 atopic keratoconjunctivitis 10.3 IL2 IGHE
25 chronic asthma 10.3 IL2 IGHE
26 pustulosis palmaris et plantaris 10.3 TNF ELANE
27 balanoposthitis 10.3 SLPI IL2
28 corneal abscess 10.3 SLPI PI3
29 aspiration pneumonitis 10.2 TNF SERPINA3
30 elephantiasis 10.2 ELANE CD4
31 rheumatoid arthritis interstitial lung disease 10.2 TNF CD4
32 palladium allergic contact dermatitis 10.2 TNF IL17A
33 chromium allergic contact dermatitis 10.2 IL2 IL17A
34 opportunistic bacterial infectious disease 10.2 TNF CD4
35 nocardiosis 10.2 TNF CD4
36 arachnoiditis 10.2 TNF CD4
37 gastrointestinal tuberculosis 10.2 TNF CD4
38 intestinal tuberculosis 10.2 TNF CD4
39 subacute lymphocytic thyroiditis 10.2 IL2 CD4
40 granuloma annulare 10.2 TNF CD4
41 mononeuritis of upper limb and mononeuritis multiplex 10.2 TNF CD4
42 mononeuritis multiplex 10.2 TNF CD4
43 lymph node tuberculosis 10.2 TNF CD4
44 central nervous system tuberculosis 10.2 TNF CD4
45 odontogenic myxoma 10.2 SERPINA3 CD36
46 chemical colitis 10.2 TNF IL17A
47 tenosynovitis 10.2 TNF CD4
48 clonorchiasis 10.2 TNF IL2 IGHE
49 lung abscess 10.2 TNF CD4
50 conjunctivitis 10.2 TNF IL2 IGHE

Comorbidity relations with Farmer's Lung via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to Farmer's Lung
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Symptoms & Phenotypes for Farmer's Lung

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MGI Mouse Phenotypes related to Farmer's Lung:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 CD36 CD4 CD8A CRIP3 IL17A IL2
2 hematopoietic system MP:0005397 9.61 CD36 CD4 CD8A CRIP3 ELANE IL17A
3 immune system MP:0005387 9.28 CD36 CD4 CD8A CRIP3 ELANE IL17A
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Drugs & Therapeutics for Farmer's Lung

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Search Clinical Trials , NIH Clinical Center for Farmer's Lung

Cochrane evidence based reviews: farmer's lung

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Genetic Tests for Farmer's Lung

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Anatomical Context for Farmer's Lung

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MalaCards organs/tissues related to Farmer's Lung:

40
Lung, Skin, T Cells, B Cells, Pituitary, Neutrophil
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Publications for Farmer's Lung

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Articles related to Farmer's Lung:

(show top 50) (show all 759)
# Title Authors PMID Year
1
[Relationship between severity of farmer's lung and the level of soluble interleukin 2 receptors in serum]. 61 54
8937141 1996
2
[A study on interleukin 2 and soluble interleukin 2 receptor in serum and bronchoalveolar lavage fluid from patients with farmer's lung]. 54 61
1770680 1991
3
Sooty bark disease of maples: the risk for hypersensitivity pneumonitis by fungal spores not only for woodman. 61
33478566 2021
4
Studying smoking benefit in farmer's lung to understand Covid-19. 61
32779722 2020
5
[A case of farmer's lung associated with allergic bronchopulmonary aspergillosis]. 61
31870516 2020
6
[ALLERGIC ALVEOLITIS [ARTICLE IN POLISH]]. 61
33055317 2020
7
Characteristics of hypersensitivity pneumonitis diagnosed by interstitial and occupational lung disease multi-disciplinary team consensus. 61
31295673 2019
8
Hypersensitivity pneumonitis: A new strategy for serodiagnosis and environmental surveys. 61
30961934 2019
9
Farmer's lung disease: Analysis of 75 cases. 61
28587854 2017
10
Mold and Human Health: a Reality Check. 61
28299723 2017
11
Emphysema in active farmer's lung disease. 61
28614400 2017
12
Farmer's Lung Disease. A Review. 61
26874898 2016
13
High prevalence of obstructive lung disease in non-smoking farmers: The Irish farmers lung health study. 61
27215498 2016
14
Identification of Antigenic Proteins from Lichtheimia corymbifera for Farmer's Lung Disease Diagnosis. 61
27490813 2016
15
Combined pulmonary fibrosis and emphysema in hypersensitivity pneumonitis. 61
26689249 2015
16
Western blotting as a tool for the serodiagnosis of farmer's lung disease: validation with Lichtheimia corymbifera protein extracts. 61
25666836 2015
17
Prevalence and risk factors for farmer's lung in greenhouse farmers: an epidemiological study of 5,880 farmers from Northeast China. 61
25344645 2015
18
[Chronic Farmer's lung disease with emphysema]. 61
25847206 2015
19
Cross-Shift Changes in Lung Function Among Palestinian Farmers During High- and Low-Exposure Periods to Pesticides: A Longitudinal Study. 61
25386741 2015
20
Draft Genome Sequence of the Principal Etiological Agent of Farmer's Lung Disease, Saccharopolyspora rectivirgula. 61
25523783 2014
21
Immunoreactive proteins of Saccharopolyspora rectivirgula for farmer's lung serodiagnosis. 61
25264606 2014
22
Assessing the implications of contradictory farm exposure data in an aging rural population. 61
24959758 2014
23
Draft Genome Sequence of Saccharopolyspora rectivirgula. 61
24407634 2014
24
[A case report of farmer's lung]. 61
24370311 2013
25
Nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan. 61
23978646 2013
26
Quantification of Saccharopolyspora rectivirgula in composting plants: assessment of the relevance of S. rectivirgula. 61
23579625 2013
27
Defining syndromes using cattle meat inspection data for syndromic surveillance purposes: a statistical approach with the 2005-2010 data from ten French slaughterhouses. 61
23628140 2013
28
[Domestic hypersensitivity pneumonitis]. 61
23101639 2012
29
Aspergillus species recombinant antigens for serodiagnosis of farmer's lung disease. 61
22608571 2012
30
[Farmer's lung antigens in Germany]. 61
22477566 2012
31
Characterization of bioaerosols from dairy barns: reconstructing the puzzle of occupational respiratory diseases by using molecular approaches. 61
22367078 2012
32
Farmer's lung-induced hypersensitivity pneumonitis complicated by shock. 61
22005584 2012
33
Bioaerosol exposure assessment in the workplace: the past, present and recent advances. 61
22267210 2012
34
Bronchoalveolar lavage in hypersensitivity pneumonitis: a series of 139 patients. 61
22309080 2012
35
Farmer's lung in a case after bullectomy. 61
22398814 2012
36
Salt induces biosynthesis of hemolytically active compounds in the xerotolerant food-borne fungus Wallemia sebi. 61
22092533 2012
37
Pneumomediastinum as a primary manifestation of chronic hypersensitivity pneumonitis. 61
22129907 2011
38
Consequences of respiratory exposures in the farm environment. 61
22523860 2011
39
Work-related lung diseases. 61
22997873 2011
40
[Chronic and acute hypersensitivity pneumonitis in a dairy farmer and his son]. 61
21346406 2011
41
[Case of bird-related hypersensitivity pneumonitis in a farmer]. 61
21226310 2010
42
New evidence of the involvement of Lichtheimia corymbifera in farmer's lung disease. 61
20353311 2010
43
Genomics and the ancient origins of the daptomycin biosynthetic gene cluster. 61
20648020 2010
44
Protein kinase D1 is essential for the proinflammatory response induced by hypersensitivity pneumonitis-causing thermophilic actinomycetes Saccharopolyspora rectivirgula. 61
20142359 2010
45
Excellent visual outcome following Aspergillus flavus endogenous endophthalmitis-farmer's lung disease. 61
19132296 2010
46
Comparison of three antigenic extracts of Eurotium amstelodami in serological diagnosis of farmer's lung disease. 61
19906892 2010
47
[Epidemiology of interstitial lung diseases]. 61
19962852 2010
48
Mature CD11c(+) cells are enhanced in hypersensitivity pneumonitis. 61
19282343 2009
49
Complete genome sequence of Saccharomonospora viridis type strain (P101). 61
21304650 2009
50
Occupational hypersensitivity pneumonitis reported to the Czech National Registry Of Occupational Diseases in the period 1992-2005. 61
19672020 2009
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Variations for Farmer's Lung

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Expression for Farmer's Lung

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Search GEO for disease gene expression data for Farmer's Lung.
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Pathways for Farmer's Lung

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Pathways related to Farmer's Lung according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.49 TNF SLPI SERPINA3 PI3 IL2 IL17A
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.11 TNF IL2 IL17A IGHE CD4 CD36
3
Allograft rejection 1 36
Show member pathways
 12.63 TNF IL2 IL17A CD8A CD4
4
Immune response NFAT in immune response 23
Show member pathways
 12.43 TNF IL2 IGHE CD4
5
Th17 cell differentiation 36
Show member pathways
 12.4 TNF IL2 IL17A CD4
6
Immune response IL-23 signaling pathway 23
Show member pathways
 12.38 TNF IL2 IL17A CD4
7
T cell receptor signaling pathway 36
Show member pathways
 12.37 TNF IL2 IL17A CD8A CD4
8
NF-kappaB Signaling 4
12.35 TNF IL2 IL17A CD8A
9
Yersinia infection 36
11.91 TNF IL2 CD8A CD4
10
IL12-mediated signaling events 1
Show member pathways
 11.8 IL2 CD8A CD4
11
Interleukin-4 and 13 signaling 65
11.76 TNF IL17A IGHE CD36
12
Hematopoietic cell lineage 36
11.66 TNF CD8A CD4 CD36
13
Th1 Differentiation Pathway 64
Show member pathways
 11.5 TNF IL2 IL17A CD4
14
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.47 TNF IL2 CD8A
15
Dendritic Cells Developmental Lineage Pathway 64
11.43 TNF IL2 CD8A CD4
16
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.42 TNF IL2 CD8A CD4 CD36
17
Cytokines and Inflammatory Response 1
11.1 TNF IL2 CD4
18
Innate Lymphoid Cell Differentiation Pathways 64
10.92 TNF IL2 IL17A CD8A CD4
19
LDL Oxidation in Atherogenesis 63
10.79 TNF CD36
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GO Terms for Farmer's Lung

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Cellular components related to Farmer's Lung according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 TNF SLPI SERPINA3 PI3 IL2 IL17A
2 extracellular region GO:0005576 9.61 TNF SLPI SERPINA3 PI3 IL2 IL17A
3 external side of plasma membrane GO:0009897 9.1 TNF IL17A IGHE CD8A CD4 CD36

Biological processes related to Farmer's Lung according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.8 SLPI SERPINA3 ELANE CD36
2 immune system process GO:0002376 9.73 SLPI IL2 IL17A IGHE CD8A CD4
3 adaptive immune response GO:0002250 9.72 IL2 IL17A IGHE CD8A CD4
4 defense response to bacterium GO:0042742 9.67 TNF SLPI IGHE ELANE
5 negative regulation of endopeptidase activity GO:0010951 9.65 SLPI SERPINA3 PI3
6 negative regulation of peptidase activity GO:0010466 9.63 SLPI SERPINA3 PI3
7 defense response to Gram-positive bacterium GO:0050830 9.61 TNF IL17A CD36
8 positive regulation of interleukin-6 production GO:0032755 9.58 TNF IL17A CD36
9 positive regulation of osteoclast differentiation GO:0045672 9.51 TNF IL17A
10 cytokine-mediated signaling pathway GO:0019221 9.43 TNF IL2 IL17A IGHE CD4 CD36
11 immune response GO:0006955 9.23 TNF SLPI IL2 IL17A IGHE CD8A
12 positive regulation of blood microparticle formation GO:2000334 9.16 TNF CD36

Molecular functions related to Farmer's Lung according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase inhibitor activity GO:0030414 9.13 SLPI SERPINA3 PI3
2 serine-type endopeptidase inhibitor activity GO:0004867 8.8 SLPI SERPINA3 PI3
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Sources for Farmer's Lung

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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