Aliases & Classifications for Farsightedness

MalaCards integrated aliases for Farsightedness:

Name: Farsightedness 25
Hypermetropia 25 29 6
Hyperopia 25 55
Long-Sightedness 25
Far-Sightedness 25
Long-Sighted 25
Farsighted 25

Classifications:



External Ids:

ICD10 33 H52.0

Summaries for Farsightedness

Genetics Home Reference : 25 Farsightedness, also known as hyperopia, is an eye condition that causes blurry near vision. People who are farsighted have more trouble seeing things that are close up (such as when reading or using a computer) than things that are far away (such as when driving).

MalaCards based summary : Farsightedness, also known as hypermetropia, is related to hyperopia, high and microphthalmia with hyperopia, retinal degeneration, macrophakia, and dental anomalies. An important gene associated with Farsightedness is ANKRD11 (Ankyrin Repeat Domain 11). The drugs Ketorolac and Nepafenac have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes.

Wikipedia : 76 Far-sightedness, also known as hyperopia, is a condition of the eye in which light is focused behind,... more...

Related Diseases for Farsightedness

Diseases related to Farsightedness via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 hyperopia, high 12.1
2 microphthalmia with hyperopia, retinal degeneration, macrophakia, and dental anomalies 12.1
3 stapes ankylosis with broad thumbs and toes 11.9
4 pilodental dysplasia with refractive errors 11.7
5 nanophthalmos 1 11.6
6 leber congenital amaurosis 4 11.2
7 nanophthalmos 4 11.2
8 leber congenital amaurosis 11.2
9 cornea plana 2, autosomal recessive 11.1
10 microphthalmia, isolated 6 11.1
11 leber congenital amaurosis 6 11.1
12 anisometropia 11.1
13 leber congenital amaurosis 10 11.0
14 leber congenital amaurosis 13 11.0
15 achromatopsia 2 11.0
16 senior-loken syndrome 1 11.0
17 amblyopia 11.0
18 refractive error 11.0
19 kenny-caffey syndrome, type 2 11.0
20 vitreoretinochoroidopathy 11.0
21 leber congenital amaurosis 1 11.0
22 leber congenital amaurosis 2 11.0
23 kenny-caffey syndrome, type 1 11.0
24 microphthalmia, isolated 1 11.0
25 retinitis pigmentosa 12 11.0
26 microphthalmia, isolated 5 11.0
27 leber congenital amaurosis 7 11.0
28 leber congenital amaurosis 8 11.0
29 leber congenital amaurosis 11 11.0
30 familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis 11.0
31 cornea plana 1, autosomal dominant 10.9
32 retinal degeneration with nanophthalmos, cystic macular degeneration, and angle closure glaucoma 10.9
33 night blindness, congenital stationary, type 1a 10.9
34 retinoschisis 1, x-linked, juvenile 10.9
35 leber congenital amaurosis 3 10.9
36 leber congenital amaurosis 5 10.9
37 craniosynostosis 2 10.9
38 retinitis pigmentosa 7 10.9
39 leber congenital amaurosis 9 10.9
40 nanophthalmos 2 10.9
41 leber congenital amaurosis 12 10.9
42 fontaine progeroid syndrome 10.9
43 leber congenital amaurosis 14 10.9
44 leber congenital amaurosis 15 10.9
45 leber congenital amaurosis 16 10.9
46 leber congenital amaurosis 17 10.9
47 accommodative spasm 10.9
48 metaphyseal dysostosis-intellectual disability-conductive deafness syndrome 10.9
49 progeroid syndrome petty type 10.9
50 esotropia 10.4

Graphical network of the top 20 diseases related to Farsightedness:



Diseases related to Farsightedness

Symptoms & Phenotypes for Farsightedness

Drugs & Therapeutics for Farsightedness

Drugs for Farsightedness (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
2
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
3 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
4 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
5 Antirheumatic Agents Phase 4
6 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
7 Analgesics, Non-Narcotic Phase 4
8 Ketorolac Tromethamine Phase 4
9 Analgesics Phase 4
10 Anti-Inflammatory Agents, Non-Steroidal Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
13
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
14
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
15
Dopamine Approved Phase 2,Not Applicable 51-61-6, 62-31-7 681
16
Ranibizumab Approved Phase 2 347396-82-1 459903
17
Sulpiride Approved, Investigational Phase 2 15676-16-1 5355
18
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 1, Phase 2,Not Applicable 83-88-5 493570
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2,Not Applicable
21 Anti-Bacterial Agents Phase 1, Phase 2
22 Anti-Asthmatic Agents Phase 1, Phase 2
23 Antitubercular Agents Phase 1, Phase 2
24 Hormones Phase 1, Phase 2,Phase 2,Not Applicable
25 Topoisomerase Inhibitors Phase 1, Phase 2
26 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
27 Betamethasone benzoate Phase 1, Phase 2
28 Hormone Antagonists Phase 1, Phase 2,Not Applicable
29 Antibiotics, Antitubercular Phase 1, Phase 2
30 Betamethasone Valerate Phase 1, Phase 2 2152-44-5
31 glucocorticoids Phase 1, Phase 2
32 Betamethasone sodium phosphate Phase 1, Phase 2
33 Cytochrome P-450 CYP1A2 Inhibitors Phase 1, Phase 2
34 Anti-Infective Agents Phase 1, Phase 2,Not Applicable
35 Respiratory System Agents Phase 1, Phase 2
36 Renal Agents Phase 1, Phase 2
37 Anti-Infective Agents, Urinary Phase 1, Phase 2
38 Betamethasone-17,21-dipropionate Phase 1, Phase 2
39 Mydriatics Phase 2,Phase 1
40 Sympathomimetics Phase 2,Not Applicable
41 Dopamine Agents Phase 2,Not Applicable
42 Neurotransmitter Agents Phase 2,Not Applicable
43 Autonomic Agents Phase 2,Not Applicable
44 Vitamin B2 Phase 1, Phase 2,Not Applicable
45 Dermatologic Agents Phase 1, Phase 2,Not Applicable
46 Dextrans Phase 1, Phase 2,Not Applicable
47 Central Nervous System Depressants Phase 2
48 Antidepressive Agents Phase 2
49 Antipsychotic Agents Phase 2
50 Psychotropic Drugs Phase 2

Interventional clinical trials:

(show top 50) (show all 113)
# Name Status NCT ID Phase Drugs
1 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser in Asian Eyes Using LASIK Unknown status NCT01977807 Phase 4
2 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser Using LASIK Unknown status NCT02071576 Phase 4
3 A Prospective Safety and Effectiveness Study of a New High Repetition Rate Excimer Laser Using LASIK for the Correction of Ammetropia and Presbyopia Unknown status NCT02112968 Phase 4
4 Prospective Investigation of SUPRACOR Visual Outcomes of Presbyopic Hyperopic Patients With and Without Astigmatism Unknown status NCT01628146 Phase 4
5 Daily Wear Corneal Infiltrative Event Study Completed NCT00937105 Phase 4
6 Corneal and Conjunctival Sensitivity and Staining Study Completed NCT00455455 Phase 4 Optifree RepleniSH Multipurpose Disinfecting Solution;ReNu Multiplus Multipurpose Solution
7 Comparison of Acular LS Versus Nevanac for Pain Control in Eyes Undergoing PRK Completed NCT00347204 Phase 4 ketorolac (Acular LS);Nepafenac (Nevanac)
8 Presbyopic Supracor Treatment for Near Myopic/Hyperopic Pseudophakic Eyes Completed NCT01387360 Phase 4
9 Intrastromal Correction of Ametropia by a Femtosecond Laser Unknown status NCT00928122 Phase 3
10 Safety and Efficacy Study of Topography-Guided LASIK to Treat Myopia and Hyperopia Completed NCT01028378 Phase 3
11 Multicenter Evaluation of Safety and Effectiveness of Presbyopic LASIK for Hyperopes Completed NCT00910403 Phase 3
12 Multipurpose Disinfecting Solution Compatibility With a Silicone Hydrogel Contact Lens Completed NCT00520689 Phase 3
13 Safety and Efficacy Study to Evaluate the Treatment of Both Near and Distance Vision in a Simultaneous Laser Procedure Completed NCT01322919 Phase 3
14 Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria Completed NCT00785135 Phase 3
15 Study of Soft Contact Lens Use With 7 Day Extended Wear Completed NCT00597467 Phase 3
16 Corneal Epithelium Repair and Therapy Using Autologous Limbal Stem Cell Transplantation Unknown status NCT02148016 Phase 1, Phase 2 Levofloxacin;Betamethasone;Limbal stem cells (LSCs)
17 Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia? Completed NCT01308307 Phase 2
18 Comparative Evaluation of Corneal Staining With Balafilcon A Lenses and Two Multi-Purpose Solutions Completed NCT01024855 Phase 1, Phase 2
19 Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular Edema Recruiting NCT03161652 Phase 2 DME lactose pill;DME levosulpiride;DR lactose pill;DR levosulpiride;DR vitrectomy lactose pill;DR vitrectomy levosulpiride;DME plus ranibizumab lactose pill;DME plus ranibizumab levosulpiride
20 Safety and Efficacy of Corneal Collagen Cross-linking Following LASIK for Treatment of Hyperopia and Hyperopic Astigmatism Terminated NCT01893359 Phase 1, Phase 2 riboflavin ophthalmic solution, 0% dextran
21 Enhancement of Emmetropization in Hyperopic Infants Terminated NCT00574717 Phase 1, Phase 2
22 Creating LASIK Flaps With the LenSx Femtosecond Laser Completed NCT01556893 Phase 1
23 Visual Cortex Stimulation in Patients With Amblyopia Completed NCT00097162 Phase 1
24 Feasibility of Measurement of Optical Aberrations in Hyperopia by Using an Adaptive Optics Visual Simulator (AOVIS-I) Unknown status NCT01884805 Early Phase 1
25 Study to Evaluate the Safety and Efficacy of HI-BRITE Large Diameter Rigid Gas Permeable Contact Lens Unknown status NCT02812316 Not Applicable
26 Prevalence of Angle Closure in Caucasian Hyperopes Unknown status NCT00823706
27 Ocular Imaging With Spectral Domain Optical Coherence Tomography Unknown status NCT00926549 Not Applicable
28 Randomized, Non-inferiority Trial Comparing SMILE and LASIK Unknown status NCT01216475 Not Applicable
29 Development of a Validated Chart for Intermediate Vision Assessment Unknown status NCT02279446
30 Lipolytic Effects of GH in Human Subjects in Vivo Unknown status NCT02782221 Not Applicable Growth Hormone;Pegisomant
31 Lipolytic Effects of GH in Hypopituitary Patients in Vivo Unknown status NCT02782208 Not Applicable Acipimox;Placebo;GH substitution
32 Study to Evaluate the Clinical Performance of SynergEyes A2 Hybrid Contact Lenses Unknown status NCT01058629 Not Applicable
33 Correction of Farsightedness in Children Study Completed NCT00472212 Not Applicable
34 Hyperopia Treatment Study 1 (HTS1) - Glasses vs Observation Completed NCT01515475 Not Applicable
35 Investigation of the Effect of Different Eye Exercises on Hypermetropia in School-age Children Completed NCT03347734 Not Applicable
36 Photorefractive Keratectomy (PRK) for Hyperopia After Radial Keratotomy Completed NCT00917657 Not Applicable
37 Safety and Effectiveness Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Hyperopia Completed NCT00762281 Not Applicable
38 A Study to Evaluate the Safety and Effectiveness of the Technols 217z Zyoptix System for Hyperopia Completed NCT00348205 Not Applicable
39 High Refractive Index Material 510(k) Completed NCT00766168 Not Applicable
40 Safety and Effectiveness of Wavefront-Guided LASIK Correction of Hyperopic Refractive Errors Completed NCT01675479 Not Applicable
41 First-Sight Refractive Error Correction in the Developing World Completed NCT01598818
42 Hyperopic LASIK With Crosslinking Versus Standard LASIK Completed NCT03224013 Not Applicable
43 Pilot Dispensing Evaluation of a Plus Power Lens Completed NCT01228591 Not Applicable
44 Patient Reported Outcomes With LASIK: PROWL-2 Completed NCT01655420
45 Vision Device Validation Study Completed NCT03456245 Not Applicable
46 One-month Clinical Evaluation of Oté Sensation Multi-Purpose Solution Care System Completed NCT03278223 Not Applicable
47 Clinical Study of Visibility Tinted Clariti Contact Lens Completed NCT01996787 Not Applicable
48 Accuracy of LASIK Flaps Created With the LenSx® Femtosecond Laser - A Pilot Study Completed NCT02575911 Not Applicable
49 Clinical Performance of Habitual Wearers of Bioclear 1-day Lenses When Refitted With Biomedics 1-day Extra for 1 Week Completed NCT02406495 Not Applicable
50 Clinical Study of Clariti Monthly Contact Lens Completed NCT01392950 Not Applicable

Search NIH Clinical Center for Farsightedness

Genetic Tests for Farsightedness

Genetic tests related to Farsightedness:

# Genetic test Affiliating Genes
1 Hypermetropia 29

Anatomical Context for Farsightedness

MalaCards organs/tissues related to Farsightedness:

41
Eye, Retina, Testes, Endothelial

Publications for Farsightedness

Articles related to Farsightedness:

(show top 50) (show all 61)
# Title Authors Year
1
Comparision of Optical Low Coherence Reflectometry Versus Ultrasonic Biometry in High Hypermetropia. ( 27898517 )
2018
2
Sensitivity and specificity of school nurse screening for hypermetropia and convergence insufficiency exophoria in primary schoolchildren in Denmark. ( 30338671 )
2018
3
Cycloplegic effect of atropine compared with cyclopentolate-tropicamide combination in children with hypermetropia. ( 27397958 )
2016
4
The long-term outcome of the refractive error in children with hypermetropia. ( 25952040 )
2015
5
Passive smoking exposure might be associated with hypermetropia. ( 22670861 )
2012
6
Farsightedness (presbyopia) in a wild elderly chimpanzee: the first report. ( 20102392 )
2010
7
Chalazion-induced hypermetropia: a topographic illustration. ( 17975558 )
2008
8
Capturing myopia and hypermetropia 'phenotypes' without formal refraction. ( 17347679 )
2008
9
Association between accommodative accuracy, hypermetropia, and strabismus in children with Down's syndrome. ( 17299346 )
2007
10
Essential hypertension and hypermetropia: is there really an association? ( 17947828 )
2007
11
Hypermetropia-succeeded myopia after hyperbaric oxygen therapy. ( 16534462 )
2006
12
Hypermetropia is not associated with hypertension: the Blue Mountains Eye Study. ( 16564816 )
2006
13
Hypermetropia, axial length, and hypertension: the Tanjong Pagar survey. ( 16765692 )
2006
14
Hypermetropia is not associated with hypertension: the Blue Mountains Eye Study. ( 16876543 )
2006
15
Hereditary high hypermetropia in the Faroe Islands. ( 15823920 )
2005
16
Clinical practice. Use of lasers for vision correction of nearsightedness and farsightedness. ( 15282354 )
2004
17
Uveal effusion following laser in situ keratomileusis (LASIK) for hypermetropia. ( 15059725 )
2004
18
Wavefront aberrations following laser in situ keratomileusis and refractive lens exchange for hypermetropia. ( 15307391 )
2004
19
Oculometric characteristics of extreme hypermetropia in two faroese families. ( 15557850 )
2004
20
Associations of high hypermetropia in childhood. ( 12724716 )
2003
21
Three-year follow-up of the Artisan phakic intraocular lens for hypermetropia. ( 12867397 )
2003
22
New fix for farsightedness. ( 12085786 )
2002
23
The surgical correction of moderate hypermetropia: the management controversy. ( 12084756 )
2002
24
Myopia. Confusing myopia with hypermetropia is dangerous. ( 12411372 )
2002
25
Laser in situ keratomileusis to correct myopia, hypermetropia and astigmatism after penetrating keratoplasty for keratoconus: a series of 27 cases. ( 11794388 )
2001
26
Effect of spectacles on changes of spherical hypermetropia in infants who did, and did not, have strabismus. ( 10684846 )
2000
27
Effect of spectacles on changes of spherical hypermetropia in infants. ( 11049962 )
2000
28
A randomized comparison of prism adaptation and augmented surgery in the surgical management of esotropia associated with hypermetropia. ( 10442726 )
1999
29
Stellate ganglion block alleviates pseudo-obstruction symptoms followed by episodes of hypermetropia: case report. ( 9168223 )
1997
30
Anterior segment pathology associated with hypermetropia. ( 8832725 )
1996
31
1 Optical correction of hypermetropia in early childhood results in better visual acuity in children of 8 to 12 years. ( 21314523 )
1994
32
Visual function in hypermetropia. An electroretinographic and psychophysical study. ( 8223110 )
1993
33
Costs and methods of preventive visual screening and the relation between esotropia and increasing hypermetropia. ( 1305031 )
1992
34
Optic disc drusen and hypermetropia. ( 1818233 )
1991
35
Results of a randomised trial of treating abnormal hypermetropia from the age of 6 months. ( 2182103 )
1990
36
Accommodative convergence in hypermetropia. ( 2396654 )
1990
37
Hypermetropia in dark reared chicks and the effect of lid suture. ( 3750881 )
1986
38
A family of squints: the differing effects of hypermetropia on four siblings. ( 3801206 )
1986
39
Hypermetropia in accommodative esodeviation. ( 6502404 )
1984
40
The AC/A ratio and convergence in hypermetropia corrected with spectacles or contact lenses. ( 7055201 )
1982
41
Excessive hypermetropia: review and case report documented by echography. ( 7125435 )
1982
42
Testing for hypermetropia in the school vision screening programme. ( 7324885 )
1981
43
Hypermetropia of small animals and chromatic aberration. ( 307294 )
1978
44
Relative hypermetropia: a conception of Donders fallen into oblivion. ( 937946 )
1976
45
Amblyopia associated with anisometropic hypermetropia. ( 4529608 )
1974
46
Central serous retinopathy with transitory monocular hypermetropia--a case report. ( 4507464 )
1972
47
Transient monocular hypermetropia with transient lens opacities. ( 5249726 )
1969
48
Results and principles of a new method of optical correction of hypermetropia in cases of esotropia. ( 5755696 )
1968
49
MANAGEMENT OF HYPERMETROPIA. ( 14328342 )
1965
50
TRANSITORY MONOCULAR HYPERMETROPIA--A REPORT OF THREE CASES. ( 14217665 )
1964

Variations for Farsightedness

ClinVar genetic disease variations for Farsightedness:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DMBX1 NM_147192.2(DMBX1): c.367C> T (p.Arg123Trp) single nucleotide variant Likely pathogenic rs730882203 GRCh38 Chromosome 1, 46510953: 46510953
2 DMBX1 NM_147192.2(DMBX1): c.367C> T (p.Arg123Trp) single nucleotide variant Likely pathogenic rs730882203 GRCh37 Chromosome 1, 46976625: 46976625
3 ANKRD11 NM_013275.5(ANKRD11): c.5317G> T (p.Glu1773Ter) single nucleotide variant Pathogenic rs1114167291 GRCh37 Chromosome 16, 89347633: 89347633
4 ANKRD11 NM_013275.5(ANKRD11): c.5317G> T (p.Glu1773Ter) single nucleotide variant Pathogenic rs1114167291 GRCh38 Chromosome 16, 89281225: 89281225
5 TOPORS NM_005802.4(TOPORS): c.2666A> G (p.His889Arg) single nucleotide variant Uncertain significance rs762457246 GRCh37 Chromosome 9, 32541857: 32541857
6 TOPORS NM_005802.4(TOPORS): c.2666A> G (p.His889Arg) single nucleotide variant Uncertain significance rs762457246 GRCh38 Chromosome 9, 32541859: 32541859
7 SLC9A6 NM_001042537.1(SLC9A6): c.1346C> A (p.Ala449Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome X, 135098913: 135098913
8 SLC9A6 NM_001042537.1(SLC9A6): c.1346C> A (p.Ala449Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome X, 136016754: 136016754
9 GFOD1; MCUR1; NOL7; PHACTR1; RANBP9; RNF182; SIRT5; TBC1D7 GRCh37/hg19 6p24.1-23(chr6: 12536624-13968949) copy number gain Uncertain significance GRCh37 Chromosome 6, 12536624: 13968949
10 C5orf17; CDH10; CDH12; PRDM9 GRCh37/hg19 5p14.3-14.2(chr5: 22308420-24492723) copy number gain Uncertain significance GRCh37 Chromosome 5, 22308420: 24492723

Expression for Farsightedness

Search GEO for disease gene expression data for Farsightedness.

Pathways for Farsightedness

GO Terms for Farsightedness

Biological processes related to Farsightedness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 8.96 ANKRD11 NOG
2 face morphogenesis GO:0060325 8.62 ANKRD11 NOG

Sources for Farsightedness

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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