MCID: FSC002
MIFTS: 44

Fascioliasis

Categories: Gastrointestinal diseases, Infectious diseases, Liver diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Fascioliasis

MalaCards integrated aliases for Fascioliasis:

Name: Fascioliasis 12 73 20 54 3 44 15 17 70 32
Fasciola Hepatica Infection 12 70
Sheep Liver Fluke Infection 12
Infection by Fasciola 12
Liver Flukes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:885
ICD9CM 34 121.3
MeSH 44 D005211
NCIt 50 C128387
SNOMED-CT 67 187125007
ICD10 32 B66.3
UMLS 70 C0015652 C1331532

Summaries for Fascioliasis

CDC : 3 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all continents except Antarctica, in over 70 countries, especially where there are sheep or cattle. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The young worms move through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes that produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary : Fascioliasis, also known as fasciola hepatica infection, is related to schistosomiasis and cholangitis. An important gene associated with Fascioliasis is ALB (Albumin), and among its related pathways/superpathways are Allograft rejection and Bacterial infections in CF airways. The drugs Triclabendazole and Antiparasitic Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and eye, and related phenotype is vision/eye.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Wikipedia : 73 Fasciolosis is a parasitic worm infection caused by the common liver fluke Fasciola hepatica as well as... more...

Related Diseases for Fascioliasis

Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 423)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 31.1 IL10 IFNG GPT FABP12 ALB
2 cholangitis 30.8 IL10 GPT GGT1 ALPP ALB
3 cholelithiasis 30.8 INS GPT ALB
4 cholecystitis 30.7 GPT CP ALB
5 obstructive jaundice 30.6 SLC17A5 GPT GGT1 ALPP ALB
6 echinococcosis 30.6 MT-ND1 MT-CO1 IL10 IFNG
7 dicrocoeliasis 30.5 MT-ND1 GPT CTSL ALB
8 cholestasis 30.4 SLC17A5 GPT GGT1 CP ALPP ALB
9 amebiasis 30.3 IL1B IL10 ALB
10 pyridoxine deficiency anemia 30.3 SLC17A5 GPT
11 cysticercosis 30.3 MT-ND1 MT-CO1 IL1B IL10 CTSL
12 ostertagiasis 30.2 IL10 ALB
13 visceral leishmaniasis 30.2 IL1B IL10 IFNG ALB
14 sclerosing cholangitis 30.2 IL10 GPT GGT1 ALB
15 heterophyiasis 30.2 SELE GPT ALB
16 hemosiderosis 30.1 GPT CP ALB
17 ascending cholangitis 30.1 GPT ALB
18 disease by infectious agent 30.0 IL1B IL10 IFNG GPT ALB
19 pneumonia 30.0 IL1B IL10 IFNG ALB
20 esophageal varix 30.0 INS GPT CP ALB
21 meningitis 30.0 IL1B IL10 IFNG ALB
22 food allergy 30.0 IL10 IFNG ALB
23 gastroenteritis 30.0 IL1B IL10 IFNG ALB
24 trypanosomiasis 29.9 SELE IL1B IL10 IFNG GPT ALB
25 intestinal schistosomiasis 29.9 MT-CO1 IL10 GOT2
26 hepatitis a 29.8 IL1B IL10 IFNG GPT ALB
27 salmonellosis 29.8 IL1B IL10 IFNG GPT ALB
28 choledocholithiasis 29.8 SLC17A5 GPT GGT1 ALPP ALB
29 opisthorchiasis 29.8 IL1B GRN GPT GGT1 CTSF
30 cystic echinococcosis 29.8 MT-ND1 MT-CO1 IL10 IFNG
31 hepatitis b 29.8 SLC17A5 IFNG GPT GGT1 ALB
32 parasitic helminthiasis infectious disease 29.8 MT-ND1 MT-CO1 IL1B IL10 CTSL ALB
33 acute pancreatitis 29.7 INS IL1B IL10 GPT CTSB
34 cercarial dermatitis 29.6 MT-CO1 CTSB
35 taeniasis 29.6 MT-ND1 MT-CO1 IL10 CTSL ALB
36 amyloidosis 29.5 INS IL1B CTSB ALB
37 osteoporosis 29.5 INS IL1B IL10 IFNG ALPP ALB
38 myopathy 29.4 SLC17A5 MT-ND1 MT-CO1 INS IL1B IFNG
39 viral hepatitis 29.4 SLC17A5 INS IL1B IL10 IFNG GPT
40 liver disease 29.2 SLC17A5 INS IL1B GPT GGT1 CP
41 clonorchiasis 29.1 MT-CO1 IL10 IFNG GRN CTSL CTSF
42 liver cirrhosis 29.1 SLC17A5 INS IL1B IL10 IFNG GPT
43 hypereosinophilic syndrome 10.7
44 schistosoma mansoni infection, susceptibility/ 10.6
45 paraquat poisoning 10.5 SLC17A5 GPT
46 afferent loop syndrome 10.4 GPT ALB
47 primary hepatic neuroendocrine carcinoma 10.4 GPT ALPP
48 ankylosing spondylitis 1 10.4 GPT ALB
49 meningitis and encephalitis 10.4 CP ALB
50 uvulitis 10.4 INS GPT

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to Fascioliasis

Symptoms & Phenotypes for Fascioliasis

MGI Mouse Phenotypes related to Fascioliasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.28 CP GGT1 GOT2 GRN IFNG IL10

Drugs & Therapeutics for Fascioliasis

Drugs for Fascioliasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triclabendazole Approved, Investigational Phase 4 68786-66-3
2 Antiparasitic Agents Phase 4
3 Anti-Infective Agents Phase 4
4 Anthelmintics Phase 4
5 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase IV, Multi-center, Open-label Study to Determine the Safety, Tolerability and Clinical Outcomes Following Oral Administration of EGATEN™ (Triclabendazole) in Patients (6 Years of Age or Older) With Fascioliasis. Not yet recruiting NCT04230148 Phase 4 Egaten (Triclabendazole) 250 mg tablets
2 Pathogenesis of Liver Fluke Induced Cancer in Thailand Completed NCT00472602
3 Parasitological Evaluation of Fascioliasis in Clinically Suspected Patients and the Effect of Some Plant Extract on The Adult Worm Not yet recruiting NCT03869788

Search NIH Clinical Center for Fascioliasis

Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

Anatomical Context for Fascioliasis

MalaCards organs/tissues related to Fascioliasis:

40
Liver, T Cells, Eye, Thymus, Brain, Colon, Uterus

Publications for Fascioliasis

Articles related to Fascioliasis:

(show top 50) (show all 1975)
# Title Authors PMID Year
1
The liver profile in patients with hepatitis C virus and/or fascioliasis. 61 54
16927859 2006
2
Immunochemical characterization of alkaline phosphatase from the fluid of sterile and fertile Echinococcus granulosus cysts. 61 54
12733063 2003
3
Glutathione and related enzymes in fascioliasis before and after treatment with bithionol. 61 54
1977927 1990
4
Surgically resected hepatic mass caused by fascioliasis. 61
33471251 2021
5
Rapid detection of seven indexes in sheep serum based on Raman spectroscopy combined with DOSC-SPA-PLSR-DS model. 61
33307346 2021
6
Prevalence of Fascioliasis and Associated Economic Losses in Cattle Slaughtered at Lira Municipality Abattoir in Northern Uganda. 61
33806313 2021
7
Recent Developments in Recombinant Proteins for Diagnosis of Human Fascioliasis. 61
32974849 2021
8
Serum liver enzyme profile in Timor deer (Cervus timorensis) with fascioliasis in Indonesia. 61
33797525 2021
9
Accurate and rapid detection of Fasciola hepatica copro-DNA in sheep using loop-mediated isothermal amplification (LAMP) technique. 61
33624950 2021
10
Diagnosis and Risk Factors of Bovine and Human Fascioliasis in Cattle Farms from a Venezuelan Andean Rural Area. 61
33547991 2021
11
Characterization and localization of antigens for serodiagnosis of human paragonimiasis. 61
33415393 2021
12
Molecular, Morphological, and Spatial Study of Galba schirazensis (Pulmonata, Lymnaeidae) from Southeastern Iran. 61
33786047 2021
13
Efficacy of a multivalent vaccine against Fasciola hepatica infection in sheep. 61
33509286 2021
14
Fasciola Hepatica Induced Hepatic Abscess Treated with Triclabendazole. 61
33495431 2021
15
Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver. 61
33430759 2021
16
Concurrent Infection of Fascioliasis andTrypanosomosis and Associated Risk Factors in Local Zebu Breed Cattle of Western Ethiopia. 61
33564623 2021
17
Fascioliasis and fasciolopsiasis: Current knowledge and future trends. 61
33278757 2021
18
Identification of Adult Fasciola spp. Using Matrix-Assisted Laser/Desorption Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry. 61
33396299 2020
19
Triclabendazole for the treatment of human fascioliasis and the threat of treatment failures. 61
33267701 2020
20
Seroepidemiology of human fascioliasis in rural and nomad areas of Lorestan Province, western Iran, in 2016 and 2017. 61
33184547 2020
21
Ovicidal in vitro activity of the fixed oil of Helianthus annus L. and the essential oil of Cuminum cyminum L. against Fasciola hepatica (Linnaeus, 1758). 61
32871143 2020
22
The prevalence and risk factors of liver fluke infection in Mexican horses, donkeys and mules in tropical and temperate regions. 61
33006039 2020
23
Seroprevalence of fascioliasis in the eastern region of Turkey: an eight-year investigation. 61
33361036 2020
24
Effectiveness of Fasciola gigantica excretory-secretory and recombinant cathepsin L antigens for rapid diagnosis of human fascioliasis using immunochromatographic devices. 61
33009945 2020
25
Prevalence and distribution of livestock schistosomiasis and fascioliasis in Côte d'Ivoire: results from a cross-sectional survey. 61
33203412 2020
26
Early Postnatal and Preschool-Age Infection by Fasciola spp.: Report of Five Cases from Vietnam and Worldwide Review. 61
32618259 2020
27
Use of the PCR in a Combined Methodological Approach for the Study of Human Fascioliasis in an Endemic Area. 61
33113104 2020
28
Fasciola hepatica infection in cattle and the use of simulation models for endemic areas. 61
32907641 2020
29
Atypical Presentation of a Rare Parasitic Infection with Fasciola hepatica: A Multidisciplinary Case Report. 61
32936789 2020
30
Equines as reservoirs of human fascioliasis: transmission capacity, epidemiology and pathogenicity in Fasciola hepatica-infected mules. 61
32907643 2020
31
Impact of fascioliasis reinfection on Fasciola hepatica egg shedding: relationship with the immune-regulatory response. 61
32371223 2020
32
Designing a vaccine for fascioliasis using immunogenic 24 kDa mu-class glutathione s-transferase. 61
32387753 2020
33
Milk As a New Diagnostic Tool for Rapid Detection of Fascioliasis in Dairy Goats Using Excretory/Secretory Antigen. 61
32990897 2020
34
Rapid detection of Galba truncatula in water sources on pasture-land using loop-mediated isothermal amplification for control of trematode infections. 61
32998778 2020
35
Closing the Brief Case: What a Fluke! A Case of Fascioliasis with Pulmonary Involvement in a Peace Corps Volunteer. 61
32963081 2020
36
The Brief Case: What a Fluke! A Case of Fascioliasis with Pulmonary Involvement in a Peace Corps Volunteer. 61
32963080 2020
37
Evidence of sequestration of triclabendazole and associated metabolites by extracellular vesicles of Fasciola hepatica. 61
32778698 2020
38
Serological Study of Fascioliasis Using Indirect ELISA in Gorgan City, Golestan Province, Northern Iran. 61
33082807 2020
39
Pharmacological Uses of the Plants Belonging to the Genus Commiphora. 61
32614755 2020
40
Selective flukicide treatment of non-lactating cows and the corresponding production impact of Fasciola hepatica in dairy herds in Sweden. 61
32682280 2020
41
Evaluation of the Diagnostic Performance of Recombinant Antigen B1 for Detection of Cystic Echinococcosis Using Lateral Flow Dipstick Test. 61
33082792 2020
42
Genome-wide identification and characterization of eukaryotic protein kinases. 61
32472758 2020
43
Detecting Fasciola hepatica and Fasciola gigantica microRNAs with loop-mediated isothermal amplification (LAMP). 61
32508411 2020
44
High seroprevalence of anti-Fasciola antibody among cattle farm workers and dwellers in Kelantan. 61
33612808 2020
45
Fungal and Parasitic Infections of the Liver. 61
32389369 2020
46
Human fascioliasis emergence risks in developed countries: From individual patients and small epidemics to climate and global change impacts. 61
32107024 2020
47
Incidence and geographical distribution of patients hospitalised with fascioliasis in Spain. 61
31694769 2020
48
Correction: Evaluation of nitazoxanide treatment following triclabendazole failure in an outbreak of human fascioliasis in Upper Egypt. 61
32555602 2020
49
Draft Genome of the Liver Fluke Fasciola gigantica. 61
32455229 2020
50
Biochemical and immunological investigation of fascioliasis in cattle in Egypt. 61
32636589 2020

Variations for Fascioliasis

Expression for Fascioliasis

Search GEO for disease gene expression data for Fascioliasis.

Pathways for Fascioliasis

Pathways related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 INS IL1B IL10 IFNG CTSL CTSB
2
Show member pathways
11.95 IL1B IFNG CTSL CTSB
3
Show member pathways
11.89 INS IL1B IFNG GGT1 ALB
4 11.85 SELE IL1B IFNG CTSL
5 11.78 SLC17A5 CTSL CTSF CTSB
6 11.6 IL1B IL10 IFNG
7
Show member pathways
11.57 IL1B IL10 IFNG
8 11.54 IL1B IL10 IFNG
9
Show member pathways
11.45 SELE IL1B IFNG
10 11.37 SELE INS IFNG
11 10.96 SELE IL1B IL10 IFNG
12 10.9 IL1B IL10 IFNG
13
Show member pathways
10.65 GPT GOT2
14 10.49 SELE IL1B IL10 IFNG

GO Terms for Fascioliasis

Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 INS IL1B IL10 IFNG GRN CTSL
2 extracellular exosome GO:0070062 9.91 GRN GPT GOT2 GGT1 CTSL CTSF
3 extracellular space GO:0005615 9.44 SELE INS IL1B IL10 IFNG GRN
4 lysosome GO:0005764 9.43 SLC17A5 IL1B GRN CTSL CTSF CTSB
5 endolysosome lumen GO:0036021 9.16 CTSL CTSB

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.56 SELE IL1B IL10 GGT1
2 positive regulation of cytokine production GO:0001819 9.5 INS IL10 IFNG
3 positive regulation of signaling receptor activity GO:2000273 9.4 IL10 IFNG
4 positive regulation of MHC class II biosynthetic process GO:0045348 9.37 IL10 IFNG
5 proteolysis involved in cellular protein catabolic process GO:0051603 9.33 CTSL CTSF CTSB
6 negative regulation of respiratory burst involved in inflammatory response GO:0060266 8.96 INS GRN
7 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IL1B IFNG

Molecular functions related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 IL1B IL10 IFNG GRN
2 pyridoxal phosphate binding GO:0030170 8.8 GPT GOT2 ALB

Sources for Fascioliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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