MCID: FSC002
MIFTS: 41

Fascioliasis

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Fascioliasis

MalaCards integrated aliases for Fascioliasis:

Name: Fascioliasis 12 76 53 55 3 44 15 73
Fasciola Hepatica Infection 12 73
Sheep Liver Fluke Infection 12
Infection by Fasciola 12
Liver Flukes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:885
ICD10 33 B66.3
ICD9CM 35 121.3
MeSH 44 D005211
SNOMED-CT 68 111922007 187125007

Summaries for Fascioliasis

CDC : 3 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as “the common liver fluke” or “the sheep liver fluke.” A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary : Fascioliasis, also known as fasciola hepatica infection, is related to schistosomiasis and opisthorchiasis. An important gene associated with Fascioliasis is SLC17A5 (Solute Carrier Family 17 Member 5), and among its related pathways/superpathways are Folate Metabolism and Th1 Differentiation Pathway. Affiliated tissues include liver, lung and testes.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Wikipedia : 76 Fasciolosis is a parasitic worm infection caused by the common liver fluke Fasciola hepatica as well as... more...

Related Diseases for Fascioliasis

Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 30.7 ALB IFNG IL10
2 opisthorchiasis 30.4 GPT IL1B
3 peritonitis 29.9 ALB IL10 IL1B
4 cysticercosis 29.9 IL1B MT-CO1
5 food allergy 29.7 ALB IFNG IL10
6 obstructive jaundice 29.7 ALB ALPP GPT SLC17A5
7 echinococcosis 29.4 IFNG IL10 MT-CO1
8 hepatitis b 29.4 ALB GPT IFNG SLC17A5
9 clonorchiasis 29.2 CTSL IFNG IL10
10 leishmaniasis 29.1 IFNG IL10 IL1B
11 colitis 29.1 IFNG IL10 IL1B
12 osteoporosis 28.6 ALB ALPP IFNG IL1B
13 visceral leishmaniasis 28.6 ALB IFNG IL10 IL1B
14 paraquat poisoning 10.8 GPT SLC17A5
15 pyridoxine deficiency 10.8 GPT SLC17A5
16 primary hepatic neuroendocrine carcinoma 10.8 ALPP GPT
17 nonalcoholic steatohepatitis 10.7 GPT SLC17A5
18 meningitis and encephalitis 10.7 ALB CP
19 hepatic coma 10.7 ALB GPT
20 gastrointestinal tuberculosis 10.6 ALB IFNG
21 myiasis 10.5 ALPP MT-CO1
22 histoplasmosis 10.5 IFNG SLC17A5
23 pthirus pubis infestation 10.5 ALPP MT-CO1
24 endodermal sinus tumor 10.5 ALB ALPP
25 multidrug-resistant tuberculosis 10.5 IL10 SLC17A5
26 compartment syndrome 10.5 ALB SLC17A5
27 legionnaires' disease 10.5 ALB SLC17A5
28 hyperlucent lung 10.5 IFNG IL10
29 parasitic ectoparasitic infectious disease 10.5 ALPP MT-CO1
30 sporotrichosis 10.5 IFNG IL10
31 kwashiorkor 10.5 ALB GPT SLC17A5
32 hepatitis 10.5
33 baylisascariasis 10.5 IFNG IL10
34 analbuminemia 10.5 ALB GPT SLC17A5
35 acute liver failure 10.5 ALB GPT SLC17A5
36 chronic inflammatory demyelinating polyradiculoneuropathy 10.5 ALB IFNG
37 hepatic tuberculosis 10.4 ALB ALPP GPT
38 tuberculous peritonitis 10.4 ALB IFNG
39 bilirubin metabolic disorder 10.4 ALB GPT SLC17A5
40 hepatic encephalopathy 10.4 ALB GPT SLC17A5
41 pericardial tuberculosis 10.4 IFNG IL10
42 tuberculoid leprosy 10.4 IFNG IL10
43 boutonneuse fever 10.4 CP SELE
44 uremic pruritus 10.4 IL1B SLC17A5
45 viral hepatitis 10.4 ALB GPT SLC17A5
46 toxic oil syndrome 10.4 CP IFNG
47 buruli ulcer 10.4 IFNG IL10
48 multicentric castleman disease 10.4 IFNG IL10
49 hypersensitivity reaction type iii disease 10.4 ALB SELE
50 liver cirrhosis 10.4 ALB GPT SLC17A5

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to Fascioliasis

Symptoms & Phenotypes for Fascioliasis

Drugs & Therapeutics for Fascioliasis

Search Clinical Trials , NIH Clinical Center for Fascioliasis

Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

Anatomical Context for Fascioliasis

MalaCards organs/tissues related to Fascioliasis:

41
Liver, Lung, Testes, Brain, T Cells, Endothelial, Skin

Publications for Fascioliasis

Articles related to Fascioliasis:

(show top 50) (show all 577)
# Title Authors Year
1
Lethal Fascioliasis in Capybaras (Hydrochoerus hydrochaeris) in Brazil. ( 29185852 )
2018
2
Cross-Sectional Serological Survey of Human Fascioliasis in Canutama Municipality in Western Amazon, Brazil. ( 29593895 )
2018
3
Bile duct fascioliasis. ( 29916486 )
2018
4
Risk factors for human fascioliasis in schoolchildren in BaA+os del Inca, Cajamarca, Peru. ( 29860359 )
2018
5
Human case of Fasciola gigantica-like infection, review of human fascioliasis reports in Nepal, and epidemiological analysis within the South Central Asia. ( 29975653 )
2018
6
Endoscopic diagnosis and treatment of biliary obstruction due to acute cholangitis and acute pancreatitis secondary to Fasciola hepatica infection. ( 29350372 )
2018
7
Design and synthesis of a new peptide derived from Fasciola gigantica cathepsin L1 with potential application in serodiagnosis of fascioliasis. ( 29679594 )
2018
8
Prolonged antibiotic use leading to Clostridium difficile colitis in an ill returned traveller with acute fascioliasis. ( 29608740 )
2018
9
Accuracy of a diagnostic model based on serum biochemical parameters in detecting cows at an increased risk of chronic fascioliasis. ( 29657001 )
2018
10
Comparison of recombinant cathepsins L1, L2, and L5 as ELISA targets for serodiagnosis of bovine and ovine fascioliasis. ( 29564626 )
2018
11
Prevalence of bovine fascioliasis, areas at risk and ensuing losses in the state of GoiA!s, Brazil. ( 29846445 )
2018
12
Hepatic fascioliasis presenting with bile duct obstruction: a case report. ( 29158867 )
2017
13
Immunodiagnosis of Human Fascioliasis: An Update of Concepts and Performances of the Serological Assays. ( 28764235 )
2017
14
Fascioliasis risk factors and space-time clusters in domestic ruminants in Bangladesh. ( 28482863 )
2017
15
High prevalence of cattle fascioliasis in coastal areas of Thua Thien Hue province, Vietnam. ( 28458272 )
2017
16
A case of biliary fascioliasis mimicking a common bile duct tumor (with video). ( 28440243 )
2017
17
Fascioliasis: A Rare Parasitic Infection-Mimicking Tumor in the Liver: Report of Two Cases. ( 28272650 )
2017
18
Epidemiology of bovine fascioliasis in the Nile Delta region of Egypt: Its prevalence, evaluation of risk factors, and its economic significance. ( 29184371 )
2017
19
Human Cases of Fascioliasis in Fujian Province, China. ( 28285507 )
2017
20
Prevalence of fascioliasis (liver flukes) infection in cattle and buffaloes slaughtered at the municipal abattoir of El-Kharga, Egypt. ( 28919682 )
2017
21
Expression, purification and in vitro refolding of the recombinant truncated Saposin-like protein 2 antigen for development of diagnosis of human fascioliasis. ( 28300559 )
2017
22
Seroprevalence and Risk Factors of Fascioliasis in Yaks, Bos grunniens, from Three Counties of Gansu Province, China. ( 28285513 )
2017
23
Production of Monoclonal Antibody Against Excretory-Secretory Antigen of Fasciola hepatica and Evaluation of Its Efficacy in the Diagnosis of Fascioliasis. ( 28186433 )
2017
24
Fascioliasis: A report on a case presenting with abdominal pain. ( 28988787 )
2017
25
DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis. ( 28158188 )
2017
26
First case report of retroperitoneal metastasis of fascioliasis after surgery. ( 29390366 )
2017
27
Human fascioliasis by Fasciola hepatica: the first case report in Nepal. ( 28870243 )
2017
28
Fascioliasis-a rare cause of hepatic nodules. ( 28566417 )
2017
29
Hepatic fascioliasis in Mashhad, Northeast Iran: first report. ( 28954086 )
2017
30
Evaluation of modified Dennis parasitological technique for diagnosis of bovine fascioliasis. ( 27622626 )
2016
31
A pediatric case of Fascioliasis with eosinophilic pneumonia. ( 27922247 )
2016
32
Evaluation of patients diagnosed with fascioliasis: A six-year experience at a university hospital in Turkey. ( 27131001 )
2016
33
Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012. ( 27595647 )
2016
34
Animal Fascioliasis: Perspectives from high altitudinal regions. ( 27890078 )
2016
35
Epidemiological analysis of human fascioliasis in northeastern Punjab, Pakistan. ( 26763724 )
2016
36
Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series. ( 26808543 )
2016
37
First Report of Human Fascioliasis in an Endemic Region of Bovine Fascioliasis in Caldas-Colombia. ( 27045315 )
2016
38
Human fascioliasis endemic areas in Argentina: multigene characterisation of the lymnaeid vectors and climatic-environmental assessment of the transmission pattern. ( 27229862 )
2016
39
Development of Two FhSAP2 Recombinant-Based Assays for Immunodiagnosis of Human Chronic Fascioliasis. ( 27549636 )
2016
40
Seroprevalence of Human Fascioliasis in Chaharmahal and Bakhtiyari Province, Southwestern Iran. ( 27648421 )
2016
41
Biochemical assessment of oxidative status versus liver enzymes in patients with chronic fascioliasis. ( 26688624 )
2015
42
Screening for Zoonotic Fascioliasis in Slaughtered Large Ruminants in Abattoirs in Perak, Malaysia. ( 26868715 )
2015
43
The Endemicity of Human Fascioliasis in Guilan Province, Northern Iran: the Baseline for Implementation of Control Strategies. ( 26056669 )
2015
44
Fascioliasis: An Ongoing Zoonotic Trematode Infection. ( 26417603 )
2015
45
Diagnosis of human fascioliasis in Arusha region, northern Tanzania by microscopy and clinical manifestations in patients. ( 26695775 )
2015
46
Performance of a 27 kDa Fasciola hepatica Antigen in the Diagnosis of Human Fascioliasis. ( 25949054 )
2015
47
A Case of Fascioliasis Treated Successfully Without Sequelae in a Japanese Expatriate Living in Jakarta. ( 26309420 )
2015
48
Developing a climate-based risk map of fascioliasis outbreaks in Iran. ( 25982974 )
2015
49
The Status of Human and Animal Fascioliasis in Iran: A Narrative Review Article. ( 26622287 )
2015
50
Seroprevalence of human fascioliasis in Van province, Turkey. ( 26006203 )
2015

Variations for Fascioliasis

Expression for Fascioliasis

Search GEO for disease gene expression data for Fascioliasis.

Pathways for Fascioliasis

Pathways related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.08 ALB IFNG IL1B
2
Show member pathways
12 IFNG IL10 IL1B
3
Show member pathways
11.98 IFNG IL10 IL1B
4 11.94 IFNG IL10 IL1B
5
Show member pathways
11.87 CTSL IFNG IL1B
6 11.7 CTSL IFNG IL1B SELE
7 11.62 IFNG IL10 IL1B
8 11.56 CTSL IFNG IL1B
9 11.48 IFNG IL10 IL1B
10 11.41 IFNG IL10 IL1B
11
Show member pathways
11.3 IFNG IL1B SELE
12 11.12 IL10 IL1B
13 11.06 IFNG IL1B
14 10.95 IFNG IL10 IL1B SELE
15 10.94 IFNG IL10
16 10.89 IFNG IL1B
17 10.81 IFNG IL10 IL1B
18 10.47 IFNG IL10 IL1B SELE

GO Terms for Fascioliasis

Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ALB CP CTSL GPT IFNG IL10

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.43 IL10 IL1B SELE
2 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.16 IFNG IL1B
3 positive regulation of heterotypic cell-cell adhesion GO:0034116 8.96 IL10 IL1B
4 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IFNG IL1B

Molecular functions related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IFNG IL10 IL1B

Sources for Fascioliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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