MCID: FSC002
MIFTS: 45

Fascioliasis

Categories: Gastrointestinal diseases, Infectious diseases, Liver diseases, Rare diseases

Aliases & Classifications for Fascioliasis

MalaCards integrated aliases for Fascioliasis:

Name: Fascioliasis 12 76 53 55 3 44 15 73
Fasciola Hepatica Infection 12 73
Sheep Liver Fluke Infection 12
Infection by Fasciola 12
Liver Flukes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:885
ICD10 33 B66.3
ICD9CM 35 121.3
MeSH 44 D005211
NCIt 50 C128387

Summaries for Fascioliasis

CDC : 3 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as “the common liver fluke” or “the sheep liver fluke.” A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary : Fascioliasis, also known as fasciola hepatica infection, is related to schistosomiasis and clonorchiasis. An important gene associated with Fascioliasis is SLC17A5 (Solute Carrier Family 17 Member 5), and among its related pathways/superpathways are Allograft rejection and Toxoplasmosis. Affiliated tissues include liver, lung and testes, and related phenotypes are liver/biliary system and vision/eye

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Wikipedia : 76 Fasciolosis is a parasitic worm infection caused by the common liver fluke Fasciola hepatica as well as... more...

Related Diseases for Fascioliasis

Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 30.8 ALB IFNG IL10
2 clonorchiasis 30.3 IFNG IL10
3 opisthorchiasis 30.3 GPT IL1B
4 liver cirrhosis 30.0 ALB GPT SLC17A5
5 food allergy 29.8 ALB IFNG IL10
6 visceral leishmaniasis 29.8 ALB IFNG IL10
7 obstructive jaundice 29.8 ALB ALPP GPT SLC17A5
8 leishmaniasis 29.7 IFNG IL10 IL1B
9 hepatitis b 29.7 ALB GPT IFNG SLC17A5
10 colitis 29.7 IFNG IL10 IL1B
11 viral infectious disease 29.5 GPT IFNG IL10 IL1B
12 salmonellosis 29.5 ALB CP IFNG IL1B
13 osteoporosis 29.2 ALB ALPP IFNG IL1B INS
14 asthma 28.9 CP IFNG IL10 IL1B INS SELE
15 fascioloidiasis 11.1
16 paraquat poisoning 10.3 GPT SLC17A5
17 pyridoxine deficiency 10.3 GPT SLC17A5
18 primary hepatic neuroendocrine carcinoma 10.2 ALPP GPT
19 hepatic coma 10.2 ALB GPT
20 meningitis and encephalitis 10.2 ALB CP
21 cephalosporin allergy 10.2 IFNG IL10
22 compartment syndrome 10.2 ALB SLC17A5
23 hyperlucent lung 10.2 IFNG IL10
24 uremic pruritus 10.2 IL1B SLC17A5
25 multidrug-resistant tuberculosis 10.2 IL10 SLC17A5
26 hepatocellular carcinoma 10.2
27 panniculitis 10.2
28 vasculitis 10.2
29 sporotrichosis 10.2 IFNG IL10
30 nickel allergic contact dermatitis 10.2 IFNG IL10
31 hepatitis 10.2
32 baylisascariasis 10.2 IFNG IL10
33 penicillin allergy 10.2 IFNG IL10
34 pericardial tuberculosis 10.1 IFNG IL10
35 kwashiorkor 10.1 ALB GPT SLC17A5
36 infantile liver failure syndrome 1 10.1 ALB GPT SLC17A5
37 analbuminemia 10.1 ALB GPT SLC17A5
38 tuberculoid leprosy 10.1 IFNG IL10
39 chronic inflammatory demyelinating polyradiculoneuropathy 10.1 ALB IFNG
40 acute liver failure 10.1 ALB GPT SLC17A5
41 fungal meningitis 10.1 IFNG IL10
42 tuberculous peritonitis 10.1 ALB IFNG
43 noma 10.1 ALB INS
44 hepatic tuberculosis 10.1 ALB ALPP GPT
45 bilirubin metabolic disorder 10.1 ALB GPT SLC17A5
46 hepatic encephalopathy 10.1 ALB GPT SLC17A5
47 euthyroid sick syndrome 10.1 ALB IL1B
48 funisitis 10.1 IL10 IL1B
49 hypersplenism 10.1 ALB IFNG
50 viral hepatitis 10.1 ALB GPT SLC17A5

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to Fascioliasis

Symptoms & Phenotypes for Fascioliasis

MGI Mouse Phenotypes related to Fascioliasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.43 ALB CP IFNG IL10 INS SELE
2 vision/eye MP:0005391 9.1 CP IFNG IL10 INS SELE SLC17A5

Drugs & Therapeutics for Fascioliasis

Search Clinical Trials , NIH Clinical Center for Fascioliasis

Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

Anatomical Context for Fascioliasis

MalaCards organs/tissues related to Fascioliasis:

41
Liver, Lung, Testes, T Cells, Lymph Node, Skin, Heart

Publications for Fascioliasis

Articles related to Fascioliasis:

(show top 50) (show all 878)
# Title Authors Year
1
Lethal Fascioliasis in Capybaras (Hydrochoerus hydrochaeris) in Brazil. ( 29185852 )
2018
2
Cross-Sectional Serological Survey of Human Fascioliasis in Canutama Municipality in Western Amazon, Brazil. ( 29593895 )
2018
3
Bile duct fascioliasis. ( 29916486 )
2018
4
Risk factors for human fascioliasis in schoolchildren in BaA+os del Inca, Cajamarca, Peru. ( 29860359 )
2018
5
Human case of Fasciola gigantica-like infection, review of human fascioliasis reports in Nepal, and epidemiological analysis within the South Central Asia. ( 29975653 )
2018
6
Endoscopic diagnosis and treatment of biliary obstruction due to acute cholangitis and acute pancreatitis secondary to Fasciola hepatica infection. ( 29350372 )
2018
7
Design and synthesis of a new peptide derived from Fasciola gigantica cathepsin L1 with potential application in serodiagnosis of fascioliasis. ( 29679594 )
2018
8
Prolonged antibiotic use leading to Clostridium difficile colitis in an ill returned traveller with acute fascioliasis. ( 29608740 )
2018
9
Accuracy of a diagnostic model based on serum biochemical parameters in detecting cows at an increased risk of chronic fascioliasis. ( 29657001 )
2018
10
Comparison of recombinant cathepsins L1, L2, and L5 as ELISA targets for serodiagnosis of bovine and ovine fascioliasis. ( 29564626 )
2018
11
Prevalence of bovine fascioliasis, areas at risk and ensuing losses in the state of GoiA!s, Brazil. ( 29846445 )
2018
12
Assessment of Fasciola hepatica glutathione S-transferase as an antigen for serodiagnosis of human chronic fascioliasis. ( 29990477 )
2018
13
Human fascioliasis infection sources, their diversity, incidence factors, analytical methods and prevention measures. ( 29991363 )
2018
14
Prevalence of human and animal fascioliasis in Iran: Systematic Review and Meta-analysis. ( 30113004 )
2018
15
Epidemiology of Fascioliasis in Kermanshah Province, Western Iran. ( 30181994 )
2018
16
A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea. ( 30196671 )
2018
17
Epidemiological and ultrasonographic investigation of bovine fascioliasis in smallholder production system in Eastern Nile Delta of Egypt. ( 30220394 )
2018
18
Numerous Fasciola plasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis. ( 30246668 )
2018
19
Evaluation of a set of refolded recombinant antigens for serodiagnosis of human fascioliasis. ( 30281608 )
2018
20
Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru: a preliminary report. ( 29768560 )
2018
21
Fasciola hepatica infection in water buffalo Bubalus bubalis in three provinces of the Nile Delta, Egypt: a cross-sectional study. ( 29151443 )
2018
22
Naltrexone; as an efficient adjuvant in induction of Th1 immunity and protection against Fasciola hepatica infection. ( 29729492 )
2018
23
Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection. ( 30189903 )
2018
24
Socioeconomic Factors Associated with Fasciola hepatica Infection Among Children from 26 Communities of the Cusco Region of Peru. ( 30226136 )
2018
25
Echinococcus granulosus hydatid cyst location is modified by Fasciola hepatica infection in cattle. ( 30305164 )
2018
26
Fasciola hepatica infection in children actively detected in a survey in rural areas of Mardan district, Khyber Pakhtunkhawa province, northern Pakistan. ( 30445198 )
2018
27
Histopathological findings of Fasciola hepatica infection in non-native European hare (Lepus europaeus) in Southern Chile. ( 30462821 )
2018
28
Hepatic fascioliasis presenting with bile duct obstruction: a case report. ( 29158867 )
2017
29
Immunodiagnosis of Human Fascioliasis: An Update of Concepts and Performances of the Serological Assays. ( 28764235 )
2017
30
Fascioliasis risk factors and space-time clusters in domestic ruminants in Bangladesh. ( 28482863 )
2017
31
High prevalence of cattle fascioliasis in coastal areas of Thua Thien Hue province, Vietnam. ( 28458272 )
2017
32
A case of biliary fascioliasis mimicking a common bile duct tumor (with video). ( 28440243 )
2017
33
Fascioliasis: A Rare Parasitic Infection-Mimicking Tumor in the Liver: Report of Two Cases. ( 28272650 )
2017
34
Epidemiology of bovine fascioliasis in the Nile Delta region of Egypt: Its prevalence, evaluation of risk factors, and its economic significance. ( 29184371 )
2017
35
Human Cases of Fascioliasis in Fujian Province, China. ( 28285507 )
2017
36
Prevalence of fascioliasis (liver flukes) infection in cattle and buffaloes slaughtered at the municipal abattoir of El-Kharga, Egypt. ( 28919682 )
2017
37
Expression, purification and in vitro refolding of the recombinant truncated Saposin-like protein 2 antigen for development of diagnosis of human fascioliasis. ( 28300559 )
2017
38
Seroprevalence and Risk Factors of Fascioliasis in Yaks, Bos grunniens, from Three Counties of Gansu Province, China. ( 28285513 )
2017
39
Production of Monoclonal Antibody Against Excretory-Secretory Antigen of Fasciola hepatica and Evaluation of Its Efficacy in the Diagnosis of Fascioliasis. ( 28186433 )
2017
40
Fascioliasis: A report on a case presenting with abdominal pain. ( 28988787 )
2017
41
DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis. ( 28158188 )
2017
42
First case report of retroperitoneal metastasis of fascioliasis after surgery. ( 29390366 )
2017
43
Human fascioliasis by Fasciola hepatica: the first case report in Nepal. ( 28870243 )
2017
44
Fascioliasis-a rare cause of hepatic nodules. ( 28566417 )
2017
45
Hepatic fascioliasis in Mashhad, Northeast Iran: first report. ( 28954086 )
2017
46
Fasciola hepatica: Infection Status of Freshwater Snails Collected from Gangwon-do (Province), Korea. ( 28285514 )
2017
47
Network Analysis of the Systemic Response to Fasciola hepatica Infection in Sheep Reveals Changes in Fibrosis, Apoptosis, Toll-Like Receptors 3/4, and B Cell Function. ( 28487699 )
2017
48
Estimation of the impact of Fasciola hepatica infection on time taken for UK beef cattle to reach slaughter weight. ( 28779120 )
2017
49
Farm-level risk factors for Fasciola hepatica infection in Danish dairy cattle as evaluated by two diagnostic methods. ( 29121986 )
2017
50
Evaluation of modified Dennis parasitological technique for diagnosis of bovine fascioliasis. ( 27622626 )
2016

Variations for Fascioliasis

Expression for Fascioliasis

Search GEO for disease gene expression data for Fascioliasis.

Pathways for Fascioliasis

Pathways related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.57 CTSL IFNG IL10 IL1B INS
2
Show member pathways
12.06 IFNG IL10 IL1B
3 12.03 IFNG IL10 IL1B
4
Show member pathways
11.98 CTSL IFNG IL1B
5
Show member pathways
11.96 ALB IFNG IL1B INS
6 11.88 ALB ALPP INS
7
Show member pathways
11.85 IFNG IL10 IL1B
8
Show member pathways
11.82 CTSL IFNG IL1B
9 11.74 IFNG IL1B INS
10 11.7 CTSL IFNG IL1B SELE
11 11.68 IFNG IL10 IL1B
12 11.64 CTSL IFNG IL1B
13 11.57 IFNG IL10 IL1B
14 11.52 IFNG IL10 IL1B
15 11.48 IFNG IL10 IL1B
16
Show member pathways
11.38 IFNG IL1B SELE
17 11.28 IFNG INS SELE
18 11.12 IFNG IL1B
19 11.02 IFNG IL10
20 10.99 IFNG IL1B
21 10.95 IFNG IL10 IL1B SELE
22 10.79 IFNG IL10 IL1B
23 10.77 GPT INS
24 10.47 IFNG IL10 IL1B SELE

GO Terms for Fascioliasis

Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ALB CP CTSL IFNG IL10 IL1B
2 extracellular space GO:0005615 9.28 ALB CP CTSL GPT IFNG IL10

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.63 ALB CP INS
2 regulation of signaling receptor activity GO:0010469 9.62 IFNG IL10 IL1B INS
3 response to lipopolysaccharide GO:0032496 9.54 IL10 IL1B SELE
4 positive regulation of cytokine secretion GO:0050715 9.43 IL10 INS
5 positive regulation of mitotic nuclear division GO:0045840 9.4 IL1B INS
6 negative regulation of lipid catabolic process GO:0050995 9.26 IL1B INS
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.16 IFNG IL1B
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 8.96 IL10 IL1B
9 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IFNG IL1B

Molecular functions related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IFNG IL10 IL1B

Sources for Fascioliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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