MCID: FSC002
MIFTS: 41

Fascioliasis

Categories: Gastrointestinal diseases, Infectious diseases, Liver diseases, Rare diseases

Aliases & Classifications for Fascioliasis

MalaCards integrated aliases for Fascioliasis:

Name: Fascioliasis 12 74 52 54 3 43 15 17 71 32
Fasciola Hepatica Infection 12 71
Sheep Liver Fluke Infection 12
Infection by Fasciola 12
Liver Flukes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:885
ICD9CM 34 121.3
MeSH 43 D005211
NCIt 49 C128387
ICD10 32 B66.3
UMLS 71 C0015652 C1331532

Summaries for Fascioliasis

CDC : 3 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all continents except Antarctica, in over 70 countries, especially where there are sheep or cattle. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The young worms move through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes that produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary : Fascioliasis, also known as fasciola hepatica infection, is related to cholecystitis and schistosomiasis. An important gene associated with Fascioliasis is ALB (Albumin), and among its related pathways/superpathways are Allograft rejection and Bacterial infections in CF airways. Affiliated tissues include liver, testes and lung, and related phenotype is immune system.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Wikipedia : 74 Fasciolosis is a parasitic worm infection caused by the common liver fluke Fasciola hepatica as well as... more...

Related Diseases for Fascioliasis

Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 397)
# Related Disease Score Top Affiliating Genes
1 cholecystitis 31.1 GPT CP ALB
2 schistosomiasis 31.0 IL10 IFNG GPT GGT1 FABP12 ALB
3 cholelithiasis 30.9 INS GPT GGT1 ALB
4 obstructive jaundice 30.9 SLC17A5 GPT GGT1 ALPP ALB
5 cholangitis 30.9 SLC17A5 IL10 GPT GGT1 ALPP ALB
6 acute cholangitis 30.8 GPT GGT1 ALB
7 echinococcosis 30.8 MT-ND1 MT-CO1 IL10 IFNG
8 dicrocoeliasis 30.7 GPT EPGN CTSL ALB
9 cholestasis 30.7 SLC17A5 GPT GGT1 CP ALPP ALB
10 pyridoxine deficiency anemia 30.6 SLC17A5 GPT
11 ascaris lumbricoides infection 30.6 IL1B IFNG EPGN
12 liver cirrhosis 30.6 SLC17A5 GPT GGT1 CP ALB
13 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.6 INS IL10 IFNG
14 paragonimiasis 30.6 MT-CO1 EPGN CTSF
15 heterophyiasis 30.5 SELE GPT ALB
16 visceral leishmaniasis 30.5 IL1B IL10 IFNG ALB
17 sclerosing cholangitis 30.5 IL10 GPT GGT1 ALB
18 diarrhea 30.4 IL1B IL10 IFNG GPT ALB
19 leptin deficiency or dysfunction 30.4 INS GPT ALB
20 mastitis 30.4 SELE CP ALB
21 ascending cholangitis 30.4 GPT ALB
22 cysticercosis 30.3 MT-ND1 MT-CO1 IL1B IL10 CTSL
23 hepatitis c 30.3 IL10 IFNG GPT GGT1
24 leishmaniasis 30.3 IL1B IL10 IFNG GPT ALB
25 food allergy 30.3 IL10 IFNG ALB
26 meningitis 30.3 IL1B IL10 IFNG ALB
27 esophageal varix 30.2 GPT GGT1 CP ALB
28 peritonitis 30.2 IL1B IL10 IFNG ALB
29 opisthorchiasis 30.2 IL1B GPT GGT1 EPGN CTSF
30 intestinal schistosomiasis 30.1 IL10 GOT2 EPGN
31 choledocholithiasis 30.1 SLC17A5 GPT GGT1 ALPP ALB
32 pancreatitis 30.1 SLC17A5 INS GGT1 CTSB
33 hepatitis b 30.0 SLC17A5 IFNG GPT GGT1 ALB
34 gastroenteritis 30.0 IL1B IL10 IFNG CP ALB
35 cystic echinococcosis 29.9 MT-ND1 MT-CO1 IL10 IFNG
36 trypanosomiasis 29.9 SELE IL1B IL10 IFNG GPT ALB
37 proteasome-associated autoinflammatory syndrome 1 29.9 SELE INS IL1B IL10 IFNG ALB
38 salmonellosis 29.8 IL1B IL10 IFNG GPT CP ALB
39 hepatitis a 29.8 INS IL10 IFNG GPT GGT1 ALB
40 acute pancreatitis 29.7 INS IL1B IL10 GPT CTSB ALB
41 clonorchiasis 29.7 IL10 IFNG EPGN CTSL CTSF CTSB
42 viral hepatitis 29.7 SLC17A5 INS IL10 IFNG GPT GGT1
43 taeniasis 29.6 MT-ND1 MT-CO1 IL10 CTSL ALB
44 liver disease 29.5 SLC17A5 INS IL1B GPT GGT1 CP
45 pneumonia 29.5 IL1B IL10 IFNG GPT CTSB ALB
46 osteoporosis 29.5 SELE INS IL1B IL10 IFNG ALPP
47 parasitic helminthiasis infectious disease 29.4 MT-ND1 MT-CO1 IL10 IFNG EPGN CTSL
48 fascioloidiasis 11.2
49 hypereosinophilic syndrome 10.8
50 schistosoma mansoni infection, susceptibility/ 10.7

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to Fascioliasis

Symptoms & Phenotypes for Fascioliasis

MGI Mouse Phenotypes related to Fascioliasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 ALB CP CTSB EPGN GGT1 IFNG

Drugs & Therapeutics for Fascioliasis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Parasitological Evaluation of Fascioliasis in Clinically Suspected Patients and the Effect of Some Plant Extract on The Adult Worm Not yet recruiting NCT03869788

Search NIH Clinical Center for Fascioliasis

Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

Anatomical Context for Fascioliasis

MalaCards organs/tissues related to Fascioliasis:

40
Liver, Testes, Lung, T Cells, Bone, Lymph Node, Brain

Publications for Fascioliasis

Articles related to Fascioliasis:

(show top 50) (show all 1884)
# Title Authors PMID Year
1
The liver profile in patients with hepatitis C virus and/or fascioliasis. 54 61
16927859 2006
2
Immunochemical characterization of alkaline phosphatase from the fluid of sterile and fertile Echinococcus granulosus cysts. 54 61
12733063 2003
3
Glutathione and related enzymes in fascioliasis before and after treatment with bithionol. 54 61
1977927 1990
4
Gross and histological lesions in the livers of sika deer with particular emphasis on fascioliasis. 61
31839651 2020
5
Case Report: Subarachnoid Hemorrhage and Eosinophilic Meningitis due to Disseminated Fascioliasis. 61
31933459 2020
6
Autochthonous Human Fascioliasis, Belgium. 61
31855542 2020
7
Development of analytical methods GC-MS vs LC-UV for the serum monitoring of an inflammatory glycotoxin (methylglyoxal): A new biomarker of bovine hepatobiliary distomatosis. 61
31707099 2020
8
Determination of the prevalence and intensity of Fasciola hepatica infection in dairy cattle from six irrigation regions of Victoria, South-eastern Australia, further identifying significant triclabendazole resistance on three properties. 61
31918044 2020
9
Triclabendazole for the treatment of fascioliasis. 61
31942877 2019
10
Fasciola hepatica in a country of low incidence: a tricky diagnosis. 61
31929986 2019
11
Triclabendazole in the treatment of human fascioliasis: a review. 61
31638149 2019
12
Cryptic intermediate snail host of the liver fluke Fasciola hepatica in Africa. 61
31801595 2019
13
Immunomodulatory effects of Moringa oleifera leaves aqueous extract in sheep naturally co-infected with Fasciola gigantica and Clostridium novyi. 61
31749528 2019
14
Lymnaeid Snail Vectors of Fascioliasis, Including the First Finding of Lymnaea neotropica in Ecuador, Assessed by Ribosomal DNA Sequencing in the Southern Zone Close to the Peru Border. 61
31420774 2019
15
Highlights of human ectopic fascioliasis: a systematic review. 61
31507248 2019
16
Incidence and geographical distribution of patients hospitalised with fascioliasis in Spain. 61
31694769 2019
17
Prevalence of bovine fascioliasis in a new-emerging focus of human fascioliasis in BoyerAhmad district, southwest of Iran. 61
31518959 2019
18
Use of the ELISA (Em2-Em18) and Western Blotting Methods on Diagnosis of Alveolar Echinococcosis 61
31591873 2019
19
Molecular characterization of Fasciola and Dicrocoelium species isolated from ruminant livestock in Qazvin, Iran 61
31595853 2019
20
A giant liver abscess due to Fasciola hepatica infection. 61
31545063 2019
21
Ecological niche modeling for predicting the habitat suitability of fascioliasis based on maximum entropy model in southern Caspian Sea littoral, Iran. 61
31299282 2019
22
Development of multi-epitope driven subunit vaccine against Fasciola gigantica using immunoinformatics approach. 61
31279880 2019
23
A socio-economic study of Fasciola infections in cattle and sheep at the Etoudi slaughterhouse, Yaoundé, Cameroon. 61
31581956 2019
24
Biliary Fascioliasis in Chronic Calcific Pancreatitis Presenting with Ascending Cholangitis and Biliary Stricture. 61
31762732 2019
25
Evaluation of nitazoxanide treatment following triclabendazole failure in an outbreak of human fascioliasis in Upper Egypt. 61
31553716 2019
26
An unusual cause of graft loss in pediatric liver transplant recipient-Fasciola hepatica. 61
31240781 2019
27
Molecular characterization of Fasciola jacksoni from wild elephants (Elephas maximus maximus) of Sri Lanka: a taxonomic evaluation. 61
31084638 2019
28
Profiling circulating microRNAs in serum of Fasciola gigantica-infected buffalo. 61
31377228 2019
29
Genetic Characterization of Cambodian Fasciola gigantica and Dispersal Direction of the Species in Asia. 61
31442892 2019
30
Fasciola hepatica in Brazil: genetic diversity provides insights into its origin and geographic dispersion. 61
31495340 2019
31
Prevalence and risk factors of Fascioliasis in China. 61
31077642 2019
32
Fascioliasis presenting as colon cancer liver metastasis on 18F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report. 61
31528248 2019
33
First reported case of clinical fascioliasis in Santa Catarina, Brazil. 61
31340366 2019
34
Fascioliasis in buffaloes: A 5-year forecast analysis of the disease based on a 15-year survey in Brazil. 61
31340249 2019
35
Comparison of Kato-Katz Thick Smear, Mini-FLOTAC, and Flukefinder for the Detection and Quantification of Fasciola hepatica Eggs in Artificially Spiked Human Stool. 61
31074405 2019
36
Detection of Spiked Fasciola hepatica Eggs in Stool Specimens Using LAMP Technique. 61
31673256 2019
37
Liver fluke (Fasciola hepatica) co-infection with bovine tuberculosis in cattle: A prospective herd-level assessment of herd bTB risk in dairy enterprises. 61
31012527 2019
38
Mass Drug Administration of Triclabendazole for Fasciola Hepatica in Bolivia. 61
31115295 2019
39
Progress on the development of rapid diagnostic tests for foodborne neglected zoonotic helminthiases: A systematic review. 61
30946810 2019
40
Fascioliasis mimicking malignancy in an old patient. 61
31124453 2019
41
Phylogenetic analysis of Fasciola spp. isolated from slaughtered cattle in KwaZulu-Natal and Mpumalanga provinces of South Africa based on the cytochrome c oxidase subunit I mitochondrial marker. 61
31291732 2019
42
Cathepsin L Inhibitors with Activity against the Liver Fluke Identified From a Focus Library of Quinoxaline 1,4-di-N-Oxide Derivatives. 61
31247891 2019
43
Pharmaceutical Approval Update. 61
31080332 2019
44
Studies on the prevalence of fascioliasis among ruminant animals in northern Bauchi state, north-eastern Nigeria. 61
30847412 2019
45
Target animal safety testing of an oral salicylanilide suspension, oxyclozanide, for the treatment of fascioliasis in bovine in China. 61
30634022 2019
46
Molecular Phylogenetic Variability of Fasciola gigantica in Iran. 61
31110985 2019
47
Fasciola hepatica infection in children actively detected in a survey in rural areas of Mardan district, Khyber Pakhtunkhawa province, northern Pakistan. 61
30445198 2019
48
Rafoxanide, an organohalogen drug, triggers apoptosis and cell cycle arrest in multiple myeloma by enhancing DNA damage responses and suppressing the p38 MAPK pathway. 61
30583070 2019
49
Human fascioliasis in nomads: A population-based serosurvey in southwest Iran. 61
30882381 2019
50
Numerous Fasciola plasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis. 61
30246668 2019

Variations for Fascioliasis

Expression for Fascioliasis

Search GEO for disease gene expression data for Fascioliasis.

Pathways for Fascioliasis

Pathways related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 INS IL1B IL10 IFNG CTSL CTSB
2
Show member pathways
11.98 IL1B IFNG CTSL CTSB
3
Show member pathways
11.89 INS IL1B IFNG GGT1 ALB
4 11.88 SELE IL1B IFNG CTSL
5
Show member pathways
11.81 IL1B IFNG CTSL CTSB
6 11.76 SLC17A5 CTSL CTSF CTSB
7 11.7 IL1B IFNG CTSL
8 11.62 IL1B IL10 IFNG
9 11.57 IL1B IL10 IFNG
10 11.54 IL1B IL10 IFNG
11
Show member pathways
11.47 SELE IL1B IFNG
12 11.39 SELE INS IFNG
13 10.96 SELE IL1B IL10 IFNG
14 10.9 IL1B IL10 IFNG
15
Show member pathways
10.66 GPT GOT2
16 10.49 SELE IL1B IL10 IFNG

GO Terms for Fascioliasis

Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 INS IL1B IL10 IFNG EPGN CTSL
2 lysosome GO:0005764 9.55 SLC17A5 IL1B CTSL CTSF CTSB
3 extracellular space GO:0005615 9.44 SELE INS IL1B IL10 IFNG GPT
4 endolysosome lumen GO:0036021 8.96 CTSL CTSB

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.56 SELE IL1B IL10 GGT1
2 proteolysis involved in cellular protein catabolic process GO:0051603 9.5 CTSL CTSF CTSB
3 cellular response to thyroid hormone stimulus GO:0097067 9.43 CTSL CTSB
4 positive regulation of chemokine biosynthetic process GO:0045080 9.4 IL1B IFNG
5 positive regulation of MHC class II biosynthetic process GO:0045348 9.37 IL10 IFNG
6 negative regulation of protein oligomerization GO:0032460 9.16 INS ALB
7 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IL1B IFNG
8 positive regulation of mitotic nuclear division GO:0045840 8.8 INS IL1B EPGN

Molecular functions related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.8 GPT GOT2 ALB

Sources for Fascioliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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