MCID: FSC002
MIFTS: 46

Fascioliasis

Categories: Gastrointestinal diseases, Infectious diseases, Liver diseases, Rare diseases

Aliases & Classifications for Fascioliasis

MalaCards integrated aliases for Fascioliasis:

Name: Fascioliasis 12 77 54 56 45 15 17 74 3
Fasciola Hepatica Infection 12 74
Sheep Liver Fluke Infection 12
Infection by Fasciola 12
Liver Flukes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:885
ICD9CM 36 121.3
MeSH 45 D005211
NCIt 51 C128387
ICD10 34 B66.3

Summaries for Fascioliasis

CDC : 3 Above Images: Left: Fasciola hepatica egg in an unstained wet mount (400x magnification). F. hepatica eggs are broadly ellipsoidal, operculated, and measure 130–150 μm by 60–90 µm. Center: Adult Fasciola hepatica fluke stained with carmine (30mm x 13mm). Right: Fossaria bulamoides, a snail host for F. hepatica in the western United States. (Credit: DPDx; Conchology, Inc., Mactan Island, Philippines)

MalaCards based summary : Fascioliasis, also known as fasciola hepatica infection, is related to schistosomiasis and opisthorchiasis. An important gene associated with Fascioliasis is SLC17A5 (Solute Carrier Family 17 Member 5), and among its related pathways/superpathways are Allograft rejection and Tuberculosis. Affiliated tissues include liver, lung and testes, and related phenotypes are homeostasis/metabolism and liver/biliary system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Wikipedia : 77 Fasciolosis is a parasitic worm infection caused by the common liver fluke Fasciola hepatica as well as... more...

Related Diseases for Fascioliasis

Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 30.9 ALB IFNG IL10
2 opisthorchiasis 30.5 GPT IL1B
3 clonorchiasis 30.4 IFNG IL10
4 obstructive jaundice 29.9 ALB ALPP GPT SLC17A5
5 food allergy 29.9 ALB IFNG IL10
6 visceral leishmaniasis 29.9 ALB IFNG IL10
7 leishmaniasis 29.8 IFNG IL10 IL1B
8 trypanosomiasis 29.7 ALB IFNG IL10 IL1B
9 cysticercosis 29.7 IL1B MT-CO1
10 colitis 29.7 IFNG IL10 IL1B
11 hepatitis b 29.7 ALB GPT IFNG SLC17A5
12 salmonellosis 29.6 ALB CP IFNG IL1B
13 asthma 29.3 CP IFNG IL10 IL1B SELE
14 echinococcosis 29.0 IFNG IL10 MT-CO1 MT-ND1
15 fascioloidiasis 11.1
16 paraquat poisoning 10.4 GPT SLC17A5
17 pyridoxine deficiency 10.4 GPT SLC17A5
18 primary hepatic neuroendocrine carcinoma 10.4 ALPP GPT
19 meningitis and encephalitis 10.4 ALB CP
20 hepatic coma 10.3 ALB GPT
21 noma 10.3 ALB INS
22 uremic pruritus 10.3 IL1B SLC17A5
23 heterophyiasis 10.3 ALB SELE
24 funisitis 10.3 IL10 IL1B
25 kwashiorkor 10.3 ALB GPT SLC17A5
26 infantile liver failure syndrome 1 10.3 ALB GPT SLC17A5
27 analbuminemia 10.3 ALB GPT SLC17A5
28 severe nonproliferative diabetic retinopathy 10.3 ALB INS
29 hepatic tuberculosis 10.3 ALB ALPP GPT
30 acute liver failure 10.3 ALB GPT SLC17A5
31 bilirubin metabolic disorder 10.3 ALB GPT SLC17A5
32 euthyroid sick syndrome 10.3 ALB IL1B
33 hepatic encephalopathy 10.3 ALB GPT SLC17A5
34 viral hepatitis 10.2 ALB GPT SLC17A5
35 cephalosporin allergy 10.2 IFNG IL10
36 boutonneuse fever 10.2 CP SELE
37 hyperlucent lung 10.2 IFNG IL10
38 drug allergy 10.2 ALB INS
39 sporotrichosis 10.2 IFNG IL10
40 protein-energy malnutrition 10.2 ALB CP GPT
41 nickel allergic contact dermatitis 10.2 IFNG IL10
42 autoimmune gastritis 10.2 IL10 IL1B
43 retinitis pigmentosa 60 10.2 IL1B SELE
44 baylisascariasis 10.2 IFNG IL10
45 wilson disease 10.2 ALB CP GPT
46 staphylococcal toxic shock syndrome 10.2 IFNG IL1B
47 background diabetic retinopathy 10.2 ALB INS
48 actinic prurigo 10.2 IL1B SELE
49 nonalcoholic steatohepatitis 10.2 GPT INS SLC17A5
50 jejunoileitis 10.2 ALB IL1B

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to Fascioliasis

Symptoms & Phenotypes for Fascioliasis

MGI Mouse Phenotypes related to Fascioliasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 ALB CP IFNG IL10 IL1B INS
2 liver/biliary system MP:0005370 9.43 ALB CP IFNG IL10 INS SELE
3 vision/eye MP:0005391 9.1 CP IFNG IL10 INS SELE SLC17A5

Drugs & Therapeutics for Fascioliasis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Parasitological Evaluation of Fascioliasis in Clinically Suspected Patients . Not yet recruiting NCT03869788

Search NIH Clinical Center for Fascioliasis

Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

Anatomical Context for Fascioliasis

MalaCards organs/tissues related to Fascioliasis:

42
Liver, Lung, Testes, Brain, T Cells, Lymph Node, Eye

Publications for Fascioliasis

Articles related to Fascioliasis:

(show top 50) (show all 885)
# Title Authors Year
1
Case Report: Hepatic Fascioliasis in a Young Afghani Woman with Severe Wheezing, High-Grade Peripheral Eosinophilia, and Liver Lesions: A Brief Literature Review. ( 30628571 )
2019
2
Target animal safety testing of an oral salicylanilide suspension, oxyclozanide, for the treatment of fascioliasis in bovine in China. ( 30634022 )
2019
3
Prevalence of bovine fascioliasis and economic impact associated with liver condemnation in abattoirs in Mongu district of Zambia. ( 30665406 )
2019
4
Evaluation of a Commercial Enzyme-Linked Immunosorbent Assay Kit and In-House Fasciola gigantica Cysteine Proteinases-Based Enzyme-Linked Immunosorbent Assays for Diagnosis of Human Fascioliasis. ( 30675852 )
2019
5
Studies on the prevalence of fascioliasis among ruminant animals in northern Bauchi state, north-eastern Nigeria. ( 30847412 )
2019
6
Human fascioliasis in nomads: A population-based serosurvey in southwest Iran. ( 30882381 )
2019
7
Fasciola hepatica infection in children actively detected in a survey in rural areas of Mardan district, Khyber Pakhtunkhawa province, northern Pakistan. ( 30445198 )
2019
8
Lethal Fascioliasis in Capybaras (Hydrochoerus hydrochaeris) in Brazil. ( 29185852 )
2018
9
Cross-Sectional Serological Survey of Human Fascioliasis in Canutama Municipality in Western Amazon, Brazil. ( 29593895 )
2018
10
Bile duct fascioliasis. ( 29916486 )
2018
11
Risk factors for human fascioliasis in schoolchildren in BaA+os del Inca, Cajamarca, Peru. ( 29860359 )
2018
12
Human case of Fasciola gigantica-like infection, review of human fascioliasis reports in Nepal, and epidemiological analysis within the South Central Asia. ( 29975653 )
2018
13
Endoscopic diagnosis and treatment of biliary obstruction due to acute cholangitis and acute pancreatitis secondary to Fasciola hepatica infection. ( 29350372 )
2018
14
Design and synthesis of a new peptide derived from Fasciola gigantica cathepsin L1 with potential application in serodiagnosis of fascioliasis. ( 29679594 )
2018
15
Prolonged antibiotic use leading to Clostridium difficile colitis in an ill returned traveller with acute fascioliasis. ( 29608740 )
2018
16
Accuracy of a diagnostic model based on serum biochemical parameters in detecting cows at an increased risk of chronic fascioliasis. ( 29657001 )
2018
17
Comparison of recombinant cathepsins L1, L2, and L5 as ELISA targets for serodiagnosis of bovine and ovine fascioliasis. ( 29564626 )
2018
18
Prevalence of bovine fascioliasis, areas at risk and ensuing losses in the state of GoiA!s, Brazil. ( 29846445 )
2018
19
Assessment of Fasciola hepatica glutathione S-transferase as an antigen for serodiagnosis of human chronic fascioliasis. ( 29990477 )
2018
20
Human fascioliasis infection sources, their diversity, incidence factors, analytical methods and prevention measures. ( 29991363 )
2018
21
Prevalence of human and animal fascioliasis in Iran: Systematic Review and Meta-analysis. ( 30113004 )
2018
22
Epidemiology of Fascioliasis in Kermanshah Province, Western Iran. ( 30181994 )
2018
23
A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea. ( 30196671 )
2018
24
Epidemiological and ultrasonographic investigation of bovine fascioliasis in smallholder production system in Eastern Nile Delta of Egypt. ( 30220394 )
2018
25
Numerous Fasciola plasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis. ( 30246668 )
2018
26
Evaluation of a set of refolded recombinant antigens for serodiagnosis of human fascioliasis. ( 30281608 )
2018
27
Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru: a preliminary report. ( 29768560 )
2018
28
Fasciola hepatica infection in water buffalo Bubalus bubalis in three provinces of the Nile Delta, Egypt: a cross-sectional study. ( 29151443 )
2018
29
Naltrexone; as an efficient adjuvant in induction of Th1 immunity and protection against Fasciola hepatica infection. ( 29729492 )
2018
30
Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection. ( 30189903 )
2018
31
Socioeconomic Factors Associated with Fasciola hepatica Infection Among Children from 26 Communities of the Cusco Region of Peru. ( 30226136 )
2018
32
Echinococcus granulosus hydatid cyst location is modified by Fasciola hepatica infection in cattle. ( 30305164 )
2018
33
Histopathological findings of Fasciola hepatica infection in non-native European hare (Lepus europaeus) in Southern Chile. ( 30462821 )
2018
34
Patterns of Fasciola hepatica infection in Danish dairy cattle: implications for on-farm control of the parasite based on different diagnostic methods. ( 30594235 )
2018
35
Hepatic fascioliasis presenting with bile duct obstruction: a case report. ( 29158867 )
2017
36
Immunodiagnosis of Human Fascioliasis: An Update of Concepts and Performances of the Serological Assays. ( 28764235 )
2017
37
Fascioliasis risk factors and space-time clusters in domestic ruminants in Bangladesh. ( 28482863 )
2017
38
High prevalence of cattle fascioliasis in coastal areas of Thua Thien Hue province, Vietnam. ( 28458272 )
2017
39
A case of biliary fascioliasis mimicking a common bile duct tumor (with video). ( 28440243 )
2017
40
Fascioliasis: A Rare Parasitic Infection-Mimicking Tumor in the Liver: Report of Two Cases. ( 28272650 )
2017
41
Epidemiology of bovine fascioliasis in the Nile Delta region of Egypt: Its prevalence, evaluation of risk factors, and its economic significance. ( 29184371 )
2017
42
Human Cases of Fascioliasis in Fujian Province, China. ( 28285507 )
2017
43
Prevalence of fascioliasis (liver flukes) infection in cattle and buffaloes slaughtered at the municipal abattoir of El-Kharga, Egypt. ( 28919682 )
2017
44
Expression, purification and in vitro refolding of the recombinant truncated Saposin-like protein 2 antigen for development of diagnosis of human fascioliasis. ( 28300559 )
2017
45
Seroprevalence and Risk Factors of Fascioliasis in Yaks, Bos grunniens, from Three Counties of Gansu Province, China. ( 28285513 )
2017
46
Production of Monoclonal Antibody Against Excretory-Secretory Antigen of Fasciola hepatica and Evaluation of Its Efficacy in the Diagnosis of Fascioliasis. ( 28186433 )
2017
47
Fascioliasis: A report on a case presenting with abdominal pain. ( 28988787 )
2017
48
DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis. ( 28158188 )
2017
49
First case report of retroperitoneal metastasis of fascioliasis after surgery. ( 29390366 )
2017
50
Human fascioliasis by Fasciola hepatica: the first case report in Nepal. ( 28870243 )
2017

Variations for Fascioliasis

Expression for Fascioliasis

Search GEO for disease gene expression data for Fascioliasis.

Pathways for Fascioliasis

Pathways related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 CTSL IFNG IL10 IL1B INS
2 12.03 IFNG IL10 IL1B
3
Show member pathways
12 ALB IFNG IL1B INS
4
Show member pathways
11.98 CTSL IFNG IL1B
5 11.88 ALB ALPP INS
6
Show member pathways
11.86 IFNG IL10 IL1B
7
Show member pathways
11.83 CTSL IFNG IL1B
8 11.74 IFNG IL1B INS
9 11.7 CTSL IFNG IL1B SELE
10 11.68 IFNG IL10 IL1B
11 11.65 CTSL IFNG IL1B
12 11.56 IFNG IL10 IL1B
13 11.5 IFNG IL10 IL1B
14 11.46 IFNG IL10 IL1B
15
Show member pathways
11.38 IFNG IL1B SELE
16 11.24 IFNG INS SELE
17 11.01 IFNG IL10
18 10.99 IFNG IL1B
19 10.95 IFNG IL10 IL1B SELE
20 10.79 IFNG IL10 IL1B
21 10.75 GPT INS
22 10.49 IFNG IL10 IL1B SELE

GO Terms for Fascioliasis

Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ALB CP CTSL IFNG IL10 IL1B
2 extracellular space GO:0005615 9.28 ALB CP CTSL GPT IFNG IL10

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.62 IFNG IL10 IL1B INS
2 response to lipopolysaccharide GO:0032496 9.54 IL10 IL1B SELE
3 positive regulation of cytokine secretion GO:0050715 9.43 IL10 INS
4 positive regulation of mitotic nuclear division GO:0045840 9.4 IL1B INS
5 negative regulation of lipid catabolic process GO:0050995 9.26 IL1B INS
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.16 IFNG IL1B
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 8.96 IL10 IL1B
8 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IFNG IL1B

Sources for Fascioliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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