MCID: FST010
MIFTS: 33

Fasting Hypoglycemia

Categories: Rare diseases

Aliases & Classifications for Fasting Hypoglycemia

MalaCards integrated aliases for Fasting Hypoglycemia:

Name: Fasting Hypoglycemia 20 70

Classifications:



External Ids:

UMLS 70 C0271708

Summaries for Fasting Hypoglycemia

MalaCards based summary : Fasting Hypoglycemia is related to glycogen storage disease type 0 and potter's syndrome. An important gene associated with Fasting Hypoglycemia is ACADM (Acyl-CoA Dehydrogenase Medium Chain), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and PI3K-Akt signaling pathway. The drugs Glucagon and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, pancreas and pancreatic islet, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Fasting Hypoglycemia

Diseases related to Fasting Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 glycogen storage disease type 0 32.0 GYS2 GYS1
2 potter's syndrome 29.8 IGF2 IGF1
3 glycogen storage disease 29.7 IGF2 IGF1 GYS2 GYS1
4 hyperinsulinism 29.5 INSR IGF2 IGF1 GLUD1
5 hyperinsulinemic hypoglycemia 29.4 INSR IGF2 GLUD1
6 hyperglycemia 29.4 INSR IGF1 GYS2 GYS1 GLP1R
7 islet cell tumor 29.4 INSR IGF2 IGF1
8 insulin-like growth factor i 29.1 INSR IGF2 IGF1
9 hypoglycemia 28.4 POMC INSR IGF2 IGF1 GYS2 GYS1
10 glycogen storage disease 0, liver 11.2
11 acyl-coa dehydrogenase, medium-chain, deficiency of 11.0
12 phosphoenolpyruvate carboxykinase deficiency, cytosolic 11.0
13 glycogen storage disease 0, muscle 11.0
14 insulinoma 10.3
15 glycogen storage disease vi 10.2 GYS2 GYS1
16 3-hydroxyacyl-coa dehydrogenase deficiency 10.2 GLUD1 ACADM
17 growth hormone deficiency 10.1
18 ectopic cushing syndrome 10.1 POMC CRH
19 somatization disorder 10.1 POMC CRH
20 pituitary-dependent cushing's disease 10.1 POMC CRH
21 hypothalamic disease 10.1 POMC CRH
22 atypical depressive disorder 10.1 POMC CRH
23 nelson syndrome 10.1 POMC CRH
24 gangliocytoma 10.1 POMC CRH
25 mixed cell adenoma 10.1 IGF1 CRH
26 adjustment disorder 10.1 POMC CRH
27 inappropriate adh syndrome 10.1 POMC CRH
28 acute stress disorder 10.0 POMC CRH
29 functionless pituitary adenoma 10.0 POMC IGF1
30 acth deficiency, isolated 10.0 POMC CRH
31 leukemia, acute lymphoblastic 10.0
32 acidophil adenoma 10.0 POMC IGF1
33 melancholia 10.0 POMC CRH
34 dysthymic disorder 10.0 POMC CRH
35 hormone producing pituitary cancer 10.0 POMC IGF1
36 pituitary apoplexy 10.0 POMC IGF1
37 empty sella syndrome 10.0 POMC IGF1
38 pituitary carcinoma 10.0 POMC CRH
39 intracranial hypertension, idiopathic 10.0 POMC IGF1
40 adrenal cortical hypofunction 10.0 POMC CRH
41 withdrawal disorder 9.9 POMC CRH
42 hepatocellular carcinoma 9.9
43 multiple endocrine neoplasia, type i 9.9
44 carnitine palmitoyltransferase i deficiency 9.9
45 hyperinsulinemic hypoglycemia, familial, 6 9.9
46 platelet glycoprotein iv deficiency 9.9
47 aromatic l-amino acid decarboxylase deficiency 9.9
48 hyperinsulinemic hypoglycemia, familial, 5 9.9
49 hyperinsulinemic hypoglycemia, familial, 4 9.9
50 hyperprolactinemia 9.9

Graphical network of the top 20 diseases related to Fasting Hypoglycemia:



Diseases related to Fasting Hypoglycemia

Symptoms & Phenotypes for Fasting Hypoglycemia

GenomeRNAi Phenotypes related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

26 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 9.75 IGF1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.75 IGF1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-125 9.75 GYS2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-132 9.75 GYS2 IGF2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.75 IGF1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.75 IGF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 9.75 GYS2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.75 IGF1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-161 9.75 GYS2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.75 IGF2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-189 9.75 GLP1R
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 9.75 GYS2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.75 IGF1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-205 9.75 GYS2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-21 9.75 IGF1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.75 GLP1R IGF1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.75 GLP1R
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.75 IGF1
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.75 IGF2
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-67 9.75 IGF2
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.75 GLP1R
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-74 9.75 IGF2
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.75 IGF2
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.75 IGF1
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.75 IGF2

MGI Mouse Phenotypes related to Fasting Hypoglycemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 ACADM CD36 GLP1R GYS1 GYS2 IGF1
2 cellular MP:0005384 10.06 AQP7 CD36 CRH GYS1 GYS2 IGF1
3 homeostasis/metabolism MP:0005376 10.03 ACADM AQP7 CD36 CRH GLP1R GLUD1
4 endocrine/exocrine gland MP:0005379 10.02 AQP7 CD36 CRH GLP1R GLUD1 IGF1
5 growth/size/body region MP:0005378 10.02 AQP7 CD36 CRH GLP1R GLUD1 GYS1
6 adipose tissue MP:0005375 10 AQP7 CD36 CRH GLP1R IGF1 INSR
7 liver/biliary system MP:0005370 9.76 ACADM CD36 CRH GYS1 GYS2 IGF2
8 muscle MP:0005369 9.5 ACADM CD36 GYS1 GYS2 IGF1 IGF2
9 renal/urinary system MP:0005367 9.17 AQP7 CD36 CRH IGF1 IGF2 INSR

Drugs & Therapeutics for Fasting Hypoglycemia

Drugs for Fasting Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glucagon Approved 16941-32-5
2 Hormone Antagonists
3 Glucagon-Like Peptide 1
4 Hormones
5 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mini-Dose Glucagon to Treat Fasting-induced Hypoglycemia During Ramadan Recruiting NCT03970772 Glucagon Injection
2 Fasting Hypoglycemia: Diagnosis and Treatment Recruiting NCT00001276

Search NIH Clinical Center for Fasting Hypoglycemia

Genetic Tests for Fasting Hypoglycemia

Anatomical Context for Fasting Hypoglycemia

MalaCards organs/tissues related to Fasting Hypoglycemia:

40
Skeletal Muscle, Pancreas, Pancreatic Islet, Pituitary, Spleen, Colon, B Cells

Publications for Fasting Hypoglycemia

Articles related to Fasting Hypoglycemia:

(show top 50) (show all 395)
# Title Authors PMID Year
1
Refractory and Severe Hepatogenous Diabetes in a Patient with Cirrhosis Improved by Balloon-Occluded Retrograde Transvenous Obliteration of a Large Portosystemic Shunt. 61
33709280 2021
2
Glucose and lipid metabolism disorders in children and adolescents with spinal muscular atrophy types 2 and 3. 61
33685840 2021
3
SGLT2 inhibition alleviated hyperglycemia, glucose intolerance, and dumping syndrome-like symptoms in a patient with glycogen storage disease type Ia: a case report. 61
33588940 2021
4
Emerging roles of autophagy in hepatic tumorigenesis and therapeutic strategies in glycogen storage disease type Ia: A review. 61
32474930 2021
5
Three successful pregnancies in a patient with glycogen storage disease type 0. 61
33473338 2021
6
[Pancreatic proinsulinoma]. 61
33710820 2021
7
Correction of metabolic abnormalities in a mouse model of glycogen storage disease type Ia by CRISPR/Cas9-based gene editing. 61
33359667 2020
8
Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish. 61
33251496 2020
9
Benign or not benign? Deep phenotyping of liver Glycogen Storage Disease IX. 61
33317799 2020
10
Intrauterine Growth Restriction and Hypertrophic Cardiomyopathy as Prenatal Ultrasound Findings in a Case of Leprechaunism. 61
33224016 2020
11
Hyperinsulinemic Hypoglycemia in a Patient with Costello Syndrome: An Etiology to Consider in Hypoglycemia. 61
33224014 2020
12
Fanconi-Bickel syndrome in an infant with cytomegalovirus infection: A case report and review of the literature. 61
33269285 2020
13
Hyperglycemia and Hypoinsulinemia in Patients with Fanconi-Bickel Syndrome. 61
33600694 2020
14
A case report of acute pancreatitis with glycogen storage disease type IA in an adult patient and review of the literature. 61
33080702 2020
15
[A case of glycogen storage disease type Ⅰa with gout as the main clinical manifestation]. 61
32924126 2020
16
Insulinoma presenting with postprandial hypoglycemia and a low body mass index: A case report. 61
33024775 2020
17
Fanconi-Bickel Syndrome: A Review of the Mechanisms That Lead to Dysglycaemia. 61
32877990 2020
18
Non-islet cell tumor hypoglycemia as an initial presentation of hepatocellular carcinoma coupled with end-stage liver cirrhosis: A case report and review of literature. 61
32952878 2020
19
Sargassum fusiforme Polysaccharides Prevent High-Fat Diet-Induced Early Fasting Hypoglycemia and Regulate the Gut Microbiota Composition. 61
32867177 2020
20
Rare causes of hypoglycemia in adults. 61
32409005 2020
21
Spectrum of amyloglucosidase mutations in Asian Indian patients with Glycogen storage disease type III. 61
32222031 2020
22
Doege-Potter Syndrome and Pierre-Marie-Bamberger Syndrome in a Patient With Pleural Solitary Fibrous Tumor: A Rare Case With Literature Review. 61
32494533 2020
23
Survival outcomes of metabolically supported chemotherapy combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy in advanced gastric cancer. 61
32367884 2020
24
Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes. 61
31178432 2020
25
Fasting-Evoked En Route Hypoglycemia in Diabetes (FEEHD): From Guidelines to Clinical Practice. 61
31914915 2020
26
Long-term metabolic consequences of acute dioxin exposure differ between male and female mice. 61
31996693 2020
27
Insulinoma Case Admitted with Reactive Hypoglycemia Symptoms. 61
31544700 2020
28
Unusual Glycemic Presentations in a Child with a Novel Heterozygous Intragenic INSR Deletion. 61
33040071 2020
29
Attitude and safety of patients with diabetes observing the Ramadan fast. 61
30946851 2019
30
Uniparental isodisomy of chromosome 1 results in glycogen storage disease type III with profound growth retardation. 61
30916492 2019
31
Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia. 61
31033478 2019
32
Enhancement of postprandial endogenous insulin secretion rather than exogenous insulin injection ameliorated insulin antibody-induced unstable diabetes: a case report. 61
30621663 2019
33
GLUCOSE CHANGES IN A PATIENT WITH INSULIN AUTOIMMUNE SYNDROME DEMONSTRATED BY CONTINUOUS GLUCOSE MONITORING. 61
31966997 2019
34
Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia. 61
30828444 2019
35
Feasibility study of metabolically supported chemotherapy with weekly carboplatin/paclitaxel combined with ketogenic diet, hyperthermia and hyperbaric oxygen therapy in metastatic non-small cell lung cancer. 61
30931666 2019
36
The role of vasodilator-stimulated phosphoprotein (VASP) in the control of hepatic gluconeogenic gene expression. 61
31017943 2019
37
Insulin autoimmune syndrome: Three case reports. 61
30572448 2018
38
Hypoglycemia Unawareness in Insulinoma Revealed with Flash Glucose Monitoring Systems. 61
30101920 2018
39
Fasting hypoglycemia is associated with disease progression in presymptomatic early stage type 1 diabetes. 61
30098103 2018
40
An unusual presentation of post gastric bypass hypoglycemia with both postprandial and fasting hypoglycemia 61
30427165 2018
41
Multicentric insulinoma associated with multiple endocrine neoplasia type 1: One case report 61
30394721 2018
42
An open-label pilot study on preventing glucocorticoid-induced diabetes mellitus with linagliptin. 61
30285859 2018
43
Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases. 61
29784585 2018
44
Treatment with medium chain fatty acids milk of CD36-deficient preschool children. 61
29524782 2018
45
[Molecular and clinical characterization of Colombian patients suffering from type III glycogen storage disease]. 61
29809327 2018
46
Implementation of Low Glycemic Index Diet Together with Cornstarch in Post-Gastric Bypass Hypoglycemia: Two Case Reports. 61
29799438 2018
47
G6PC mRNA Therapy Positively Regulates Fasting Blood Glucose and Decreases Liver Abnormalities in a Mouse Model of Glycogen Storage Disease 1a. 61
29428299 2018
48
Late presentation of glycogen storage disease types Ia and III in children with short stature and hepatomegaly. 61
29374762 2018
49
Glycosuria and hyperglycemia in the neonatal period as the first clinical sign of Fanconi-Bickel syndrome. 61
28493372 2018
50
Severe fasting hypoglycemia in a child after total pancreatectomy with islet autotransplantation. 61
29139589 2018

Variations for Fasting Hypoglycemia

Expression for Fasting Hypoglycemia

Search GEO for disease gene expression data for Fasting Hypoglycemia.

Pathways for Fasting Hypoglycemia

Pathways related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 INSR IGF1 GYS2 GYS1
2
Show member pathways
12.6 INSR IGF2 IGF1 GYS2 GYS1
3
Show member pathways
12.29 INSR IGF2 IGF1 GYS2 GYS1
4
Show member pathways
11.89 INSR GYS2 GYS1
5 11.77 POMC GLP1R CRH
6
Show member pathways
11.55 POMC GYS2 GYS1
7
Show member pathways
11.48 INSR IGF1 GYS2 GYS1 CD36
8 11.38 CD36 AQP7 ACADM
9
Show member pathways
11.3 INSR GYS2 GYS1 CD36
10
Show member pathways
11 GYS2 GYS1
11 10.97 INSR GYS1
12
Show member pathways
10.91 IGF2 IGF1
13 10.78 IGF2 IGF1
14 10.1 POMC CRH

GO Terms for Fasting Hypoglycemia

Biological processes related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.76 INSR IGF2 IGF1 CRH
2 positive regulation of protein phosphorylation GO:0001934 9.65 INSR IGF2 CRH
3 platelet degranulation GO:0002576 9.54 IGF2 IGF1 CD36
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.5 IGF2 IGF1 CD36
5 activation of protein kinase B activity GO:0032148 9.49 INSR IGF1
6 positive regulation of MAPK cascade GO:0043410 9.46 INSR IGF2 IGF1 CD36
7 positive regulation of activated T cell proliferation GO:0042104 9.43 IGF2 IGF1
8 positive regulation of mitotic nuclear division GO:0045840 9.43 INSR IGF2 IGF1
9 positive regulation of glycolytic process GO:0045821 9.4 INSR IGF1
10 glycogen biosynthetic process GO:0005978 9.13 GYS2 GYS1 ACADM
11 positive regulation of glycogen biosynthetic process GO:0045725 8.8 INSR IGF2 IGF1

Molecular functions related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.32 IGF2 IGF1
2 glycogen (starch) synthase activity GO:0004373 9.26 GYS2 GYS1
3 hormone activity GO:0005179 9.26 POMC IGF2 IGF1 CRH
4 glycogen synthase activity, transferring glucose-1-phosphate GO:0061547 9.16 GYS2 GYS1
5 insulin-like growth factor receptor binding GO:0005159 8.8 INSR IGF2 IGF1

Sources for Fasting Hypoglycemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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