MCID: FST010
MIFTS: 36

Fasting Hypoglycemia

Categories: Rare diseases

Aliases & Classifications for Fasting Hypoglycemia

MalaCards integrated aliases for Fasting Hypoglycemia:

Name: Fasting Hypoglycemia 53 73

Classifications:



External Ids:

UMLS 73 C0271708

Summaries for Fasting Hypoglycemia

MalaCards based summary : Fasting Hypoglycemia is related to hypoglycemia and hyperglycemia. An important gene associated with Fasting Hypoglycemia is ACADM (Acyl-CoA Dehydrogenase Medium Chain), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and PI3K-Akt signaling pathway. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver, pituitary and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Fasting Hypoglycemia

Diseases related to Fasting Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 hypoglycemia 29.6 ACADM CRH GLUD1 GYS2 INSR
2 hyperglycemia 29.4 GLP1R IGF1 INSR
3 hyperinsulinism 29.4 GLUD1 IGF1 INSR
4 diabetes mellitus, noninsulin-dependent 27.8 GLP1R GYS1 IGF1 IGF2 INSR
5 glycogen storage disease 0, liver 11.1
6 acyl-coa dehydrogenase, medium-chain, deficiency of 10.9
7 phosphoenolpyruvate carboxykinase deficiency, cytosolic 10.9
8 glycogen storage disease 0, muscle 10.9
9 glycogen storage disease type 0 10.7 GYS1 GYS2
10 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.2 IGF1 INSR
11 fibromyalgia 10.1 CRH IGF1
12 donohue syndrome 10.1 IGF1 INSR
13 pseudopapilledema 10.0 IGF1 IGF2
14 insulinoma 10.0
15 acid-labile subunit deficiency 10.0 IGF1 IGF2
16 growth hormone deficiency 9.9
17 hypothalamic disease 9.9 CRH POMC
18 pituitary carcinoma 9.9 CRH POMC
19 acth deficiency, isolated 9.9 CRH POMC
20 nelson syndrome 9.9 CRH POMC
21 hypoadrenalism 9.9 CRH POMC
22 acth-secreting pituitary adenoma 9.9 CRH POMC
23 hemangiopericytoma, malignant 9.9
24 aging 9.9
25 leukemia, acute lymphoblastic 9.9
26 diabetes mellitus 9.9
27 lymphoblastic leukemia 9.9
28 acidophil adenoma 9.8 IGF1 POMC
29 pituitary infarct 9.8 IGF1 POMC
30 adrenal cortical hypofunction 9.8 CRH POMC
31 withdrawal disorder 9.8 CRH POMC
32 empty sella syndrome 9.8 IGF1 POMC
33 adrenal cortex disease 9.8 CRH POMC
34 laron syndrome 9.8 IGF1 IGF2
35 hyperpituitarism 9.8 IGF1 POMC
36 adrenal gland disease 9.7 CRH POMC
37 hypothyroidism, congenital, nongoitrous, 4 9.7 IGF1 POMC
38 hallermann-streiff syndrome 9.7 IGF1 IGF2
39 ectopic cushing syndrome 9.7 CRH POMC
40 hepatocellular carcinoma 9.7
41 multiple endocrine neoplasia, type i 9.7
42 hyperinsulinemic hypoglycemia, familial, 6 9.7
43 platelet glycoprotein iv deficiency 9.7
44 aromatic l-amino acid decarboxylase deficiency 9.7
45 hyperprolactinemia 9.7
46 glycogen storage disease 9.7
47 hepatitis 9.7
48 islet cell tumor 9.7
49 leukemia 9.7
50 malignant fibroxanthoma 9.7

Graphical network of the top 20 diseases related to Fasting Hypoglycemia:



Diseases related to Fasting Hypoglycemia

Symptoms & Phenotypes for Fasting Hypoglycemia

GenomeRNAi Phenotypes related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

26 (show all 42)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.45 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.45 POMC IGF1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.45 IGF1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.45 IGF2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.45 GYS2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.45 GYS2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.45 POMC GYS2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.45 CD36
9 Increased shRNA abundance (Z-score > 2) GR00366-A-131 10.45 GYS2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.45 IGF2 GYS2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.45 IGF1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.45 GLP1R GYS2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.45 CD36 GLP1R
14 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.45 IGF2 IGF1 GLP1R GYS2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.45 IGF1 GYS2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.45 IGF1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.45 IGF2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.45 IGF1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.45 GLP1R
20 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.45 GYS2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.45 IGF2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.45 GYS2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.45 GYS2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-208 10.45 IGF1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.45 IGF1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.45 CD36
27 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.45 POMC IGF1 CD36
28 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.45 CD36
29 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.45 POMC
30 Increased shRNA abundance (Z-score > 2) GR00366-A-4 10.45 CD36
31 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.45 CD36
32 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.45 GYS2
33 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.45 CD36
34 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.45 IGF2
35 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.45 IGF2
36 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.45 GLP1R
37 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.45 IGF2
38 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.45 IGF2
39 Increased shRNA abundance (Z-score > 2) GR00366-A-88 10.45 POMC
40 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.45 POMC
41 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.45 IGF1
42 Reduced mammosphere formation GR00396-S 9.02 IGF2 POMC GYS2 IGF1 GLP1R

MGI Mouse Phenotypes related to Fasting Hypoglycemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 INSR POMC IGF2 GLP1R GYS1 CD36
2 cardiovascular system MP:0005385 10.03 INSR POMC IGF2 ACADM GYS1 CD36
3 cellular MP:0005384 10.01 IGF2 INSR POMC CRH IGF1 GYS1
4 homeostasis/metabolism MP:0005376 10 INSR POMC GLP1R IGF2 GLUD1 ACADM
5 endocrine/exocrine gland MP:0005379 9.97 INSR POMC GLP1R IGF2 GLUD1 CD36
6 growth/size/body region MP:0005378 9.97 INSR POMC IGF2 GLP1R GLUD1 GYS1
7 adipose tissue MP:0005375 9.95 INSR POMC GLP1R CD36 CRH IGF1
8 liver/biliary system MP:0005370 9.76 INSR POMC IGF2 ACADM GYS1 CD36
9 muscle MP:0005369 9.5 INSR IGF2 ACADM GYS1 CD36 GYS2
10 renal/urinary system MP:0005367 9.1 INSR POMC IGF2 IGF1 CD36 CRH

Drugs & Therapeutics for Fasting Hypoglycemia

Drugs for Fasting Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Non Invasive Assessment of Liver Glycogen Kinetics and ATP Synthesis in Type1 Diabetics Completed NCT00481598 Not Applicable
2 Diagnosing and Treating Low Blood Sugar Levels Recruiting NCT00001276

Search NIH Clinical Center for Fasting Hypoglycemia

Genetic Tests for Fasting Hypoglycemia

Anatomical Context for Fasting Hypoglycemia

MalaCards organs/tissues related to Fasting Hypoglycemia:

41
Liver, Pituitary, Testes, Lung, Brain

Publications for Fasting Hypoglycemia

Articles related to Fasting Hypoglycemia:

(show top 50) (show all 55)
# Title Authors Year
1
Severe fasting hypoglycemia in a child after total pancreatectomy with islet autotransplantation. ( 29139589 )
2018
2
Fasting Hypoglycemia on (18)F-FDG PET/CT Scan. ( 28420855 )
2017
3
Intractable Fasting Hypoglycemia as a Manifestation of Hepatocellular Carcinoma. ( 28785493 )
2017
4
Hypothalamic glucagon signaling in fasting hypoglycemia. ( 27084528 )
2016
5
Sexual Dimorphism in Glucose and Lipid Metabolism during Fasting, Hypoglycemia, and Exercise. ( 25964778 )
2015
6
The association between fasting hypoglycemia and methylated mercaptopurine metabolites in children with acute lymphoblastic leukemia. ( 24415675 )
2014
7
Basal Insulin Use in the Non-Critical Care Setting: Is Fasting Hypoglycemia Inevitable or Preventable? ( 24876599 )
2014
8
Aromatic L-amino acid decarboxylase deficiency is a cause of long-fasting hypoglycemia. ( 24037885 )
2013
9
CD36 deficiency predisposing young children to fasting hypoglycemia. ( 20947105 )
2011
10
Poor specificity of low growth hormone and cortisol levels during fasting hypoglycemia for the diagnoses of growth hormone deficiency and adrenal insufficiency. ( 18694902 )
2008
11
Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion. ( 18635551 )
2008
12
Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency. ( 16239968 )
2005
13
Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. ( 15031319 )
2004
14
Fasting hypoglycemia in solitary fibrous tumor of the peritoneum: a diagnostic clue for an emergent situation. ( 15290507 )
2003
15
The diagnosis of fasting hypoglycemia due to an islet-cell tumor obscured by a highly specific insulin assay. ( 12679423 )
2003
16
Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia. ( 11372615 )
2001
17
Protein-sensitive and fasting hypoglycemia in children with the hyperinsulinism/hyperammonemia syndrome. ( 11241047 )
2001
18
Fasting hypoglycemia is common during maintenance therapy for childhood acute lymphoblastic leukemia. ( 11241057 )
2001
19
Primary malignant fibrous histiocytoma of the lung: IGF-II producing tumor induces fasting hypoglycemia. ( 11149628 )
2000
20
Anti-insulin receptor autoantibodies in a patient with type B insulin resistance and fasting hypoglycemia. ( 11450502 )
2000
21
Severe and recurrent fasting hypoglycemia due to growth hormone deficiency? ( 10493328 )
1999
22
[Peripheral plasma corticotropin-releasing hormone (CRH) in an aged patient with fasting hypoglycemia associated with an insufficient secretion of insulin: an implication of plasma CRH in glucose metabolism]. ( 7556777 )
1995
23
Mechanisms of fasting hypoglycemia and concomitant insulin resistance in insulinoma patients. ( 8446044 )
1993
24
Effect of insulin-induced and fasting hypoglycemia on perinatal hypoxic-ischemic brain damage. ( 1542541 )
1992
25
A practical approach to fasting hypoglycemia. ( 1545839 )
1992
26
A glucose reduction challenge in the differential diagnosis of fasting hypoglycemia: a two-center study. ( 2407752 )
1990
27
Hyperinsulinemia due to impaired insulin clearance associated with fasting hypoglycemia and postprandial hyperglycemia: an analysis of a patient with antiinsulin receptor antibodies. ( 2668322 )
1989
28
Adult nesidioblastosis. An unusual cause of fasting hypoglycemia. ( 2729774 )
1989
29
Prolonged fasting hypoglycemia due to insulin antibodies in patient with non-insulin-dependent diabetes mellitus: effect of insulin withdrawal on insulin-antibody-binding kinetics. ( 3582076 )
1987
30
Idiopathic fasting hypoglycemia in an adult. ( 3812525 )
1987
31
Fasting hypoglycemia. ( 6870429 )
1983
32
Fasting hypoglycemia associated with disopyramide. ( 6356848 )
1983
33
Hypoketonemia and age-related fasting hypoglycemia in growth hormone deficiency. ( 6341760 )
1983
34
Clinicopathologic Conference. Intra-abdominal malignancy and fasting hypoglycemia. ( 7124779 )
1982
35
Fasting hypoglycemia in adults. ( 6279046 )
1982
36
Fasting hypoglycemia resulting from hepatic carnitine palmitoyl transferase deficiency. ( 7014807 )
1981
37
Fasting hypoglycemia secondary to disopyramide therapy. Report of two cases. ( 6785461 )
1981
38
Glycemic response to glucagon during fasting hypoglycemia: an aid in the diagnosis of hyperinsulinism. ( 7351590 )
1980
39
Fasting hypoglycemia in a pup. ( 689974 )
1978
40
Spontaneous fasting hypoglycemia: basal levels of plasma free fatty acids and glycerol, blood ketone bodies, serum cholesterol and plasma growth hormone. ( 668979 )
1978
41
Fasting hypoglycemia in a pup. ( 730606 )
1978
42
An insulinoma without fasting hypoglycemia. ( 188337 )
1976
43
Fasting hypoglycemia. A clinicopathologic conference from Veterans Administration Hospital Hines, Illinois. ( 177961 )
1976
44
Hyperinsulinism in infancy: diagnosis by demonstration of abnormal response to fasting hypoglycemia. ( 940710 )
1976
45
The diagnosis of insulinomas and other causes of fasting hypoglycemia. ( 179928 )
1976
46
Fasting hypoglycemia in adults. ( 176582 )
1976
47
Hypoglycemia: Clinical implications. Part II: Fasting hypoglycemia. ( 1115649 )
1975
48
Fasting hypoglycemia, hypercalcemia and hyperprolactinemia. Multiple endocrine neoplasia, type 1? ( 4372884 )
1974
49
Fasting hypoglycemia. Diazoxide as a test for endogenous insulin release. ( 4373514 )
1974
50
Control of refractory fasting hypoglycemia in a patient with suspected insulinoma with diphenylhydantoin. ( 4358644 )
1974

Variations for Fasting Hypoglycemia

Expression for Fasting Hypoglycemia

Search GEO for disease gene expression data for Fasting Hypoglycemia.

Pathways for Fasting Hypoglycemia

Pathways related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 GYS1 GYS2 IGF1 INSR
2
Show member pathways
12.55 GYS1 GYS2 IGF1 IGF2 INSR
3
Show member pathways
12.29 GYS1 GYS2 IGF1 IGF2 INSR
4
Show member pathways
11.89 GYS1 GYS2 INSR
5 11.77 CRH GLP1R POMC
6
Show member pathways
11.68 GYS1 IGF1 IGF2
7
Show member pathways
11.51 GYS1 GYS2 POMC
8
Show member pathways
11.44 CD36 GYS1 GYS2 IGF1 INSR
9
Show member pathways
11.29 CD36 GYS1 GYS2 INSR
10 11.13 IGF1 INSR
11 11.1 GYS1 GYS2
12
Show member pathways
11 GYS1 GYS2
13 10.97 GYS1 INSR
14
Show member pathways
10.91 IGF1 IGF2
15 10.78 IGF1 IGF2
16 10.1 CRH POMC

GO Terms for Fasting Hypoglycemia

Biological processes related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.86 CRH IGF1 IGF2 INSR
2 positive regulation of protein phosphorylation GO:0001934 9.71 CRH IGF2 INSR
3 platelet degranulation GO:0002576 9.65 CD36 IGF1 IGF2
4 activation of MAPK activity GO:0000187 9.63 IGF1 IGF2 INSR
5 positive regulation of MAPK cascade GO:0043410 9.62 CD36 IGF1 IGF2 INSR
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 CD36 IGF1 IGF2
7 activation of protein kinase B activity GO:0032148 9.58 IGF1 INSR
8 positive regulation of glucose import GO:0046326 9.58 IGF1 INSR
9 cellular response to amyloid-beta GO:1904646 9.57 CD36 IGF1
10 positive regulation of activated T cell proliferation GO:0042104 9.55 IGF1 IGF2
11 response to glucose GO:0009749 9.54 GYS2 IGF1 IGF2
12 adrenal gland development GO:0030325 9.52 CRH INSR
13 positive regulation of glycolytic process GO:0045821 9.51 IGF1 INSR
14 positive regulation of insulin receptor signaling pathway GO:0046628 9.49 IGF1 IGF2
15 glycogen biosynthetic process GO:0005978 9.43 ACADM GYS1 GYS2
16 exocrine pancreas development GO:0031017 9.4 IGF2 INSR
17 positive regulation of mitotic nuclear division GO:0045840 9.33 IGF1 IGF2 INSR
18 glucose homeostasis GO:0042593 9.26 IGF1 IGF2 INSR POMC
19 positive regulation of glycogen biosynthetic process GO:0045725 8.8 IGF1 IGF2 INSR

Molecular functions related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.4 CRH POMC
2 insulin receptor binding GO:0005158 9.37 IGF1 IGF2
3 receptor activator activity GO:0030546 9.32 IGF1 IGF2
4 glycogen synthase activity, transferring glucose-1-phosphate GO:0061547 9.26 GYS1 GYS2
5 hormone activity GO:0005179 9.26 CRH IGF1 IGF2 POMC
6 glycogen (starch) synthase activity GO:0004373 9.16 GYS1 GYS2
7 insulin-like growth factor receptor binding GO:0005159 8.8 IGF1 IGF2 INSR

Sources for Fasting Hypoglycemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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