MCID: FST010
MIFTS: 39

Fasting Hypoglycemia

Categories: Rare diseases

Aliases & Classifications for Fasting Hypoglycemia

MalaCards integrated aliases for Fasting Hypoglycemia:

Name: Fasting Hypoglycemia 53 73

Classifications:



External Ids:

UMLS 73 C0271708

Summaries for Fasting Hypoglycemia

MalaCards based summary : Fasting Hypoglycemia is related to hypoglycemia and hyperinsulinism. An important gene associated with Fasting Hypoglycemia is ACADM (Acyl-CoA Dehydrogenase Medium Chain), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and PI3K-Akt signaling pathway. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include endothelial, cortex and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Fasting Hypoglycemia

Diseases related to Fasting Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 hypoglycemia 30.5 ACADM CRH GLUD1 GYS2 INSR
2 hyperinsulinism 29.8 GLUD1 IGF1 INSR
3 hyperglycemia 29.6 GLP1R IGF1 INSR
4 glycogen storage disease 0, liver 11.2
5 acyl-coa dehydrogenase, medium-chain, deficiency of 11.1
6 phosphoenolpyruvate carboxykinase deficiency, cytosolic 11.1
7 glycogen storage disease 0, muscle 11.1
8 glycogen storage disease type 0 10.2 GYS1 GYS2
9 hypothalamic disease 10.1 CRH POMC
10 gangliocytoma 10.1 CRH POMC
11 pituitary carcinoma 10.1 CRH POMC
12 acth deficiency, isolated 10.1 CRH POMC
13 nelson syndrome 10.1 CRH POMC
14 hypoadrenalism 10.1 CRH POMC
15 acth-secreting pituitary adenoma 10.1 CRH POMC
16 adrenal cortical hypofunction 10.1 CRH POMC
17 osteoporosis, juvenile 10.1 CD36 IGF1
18 withdrawal disorder 10.1 CRH POMC
19 acidophil adenoma 10.1 IGF1 POMC
20 ectopic cushing syndrome 10.1 CRH POMC
21 pituitary infarct 10.1 IGF1 POMC
22 persistent fetal circulation syndrome 10.1 CRH POMC
23 premenstrual tension 10.1 CRH POMC
24 fibromyalgia 10.0 CRH IGF1
25 spinocerebellar degeneration 10.0 CD36 CRH GLUD1
26 insulinoma 10.0
27 growth hormone deficiency 10.0
28 empty sella syndrome 10.0 IGF1 POMC
29 hyperpituitarism 10.0 IGF1 POMC
30 adrenal cortex disease 10.0 CRH POMC
31 pseudopapilledema 10.0 IGF1 IGF2
32 pituitary-dependent cushing's disease 10.0 CRH POMC
33 acid-labile subunit deficiency 10.0 IGF1 IGF2
34 adrenal gland disease 10.0 CRH POMC
35 leukemia, acute lymphoblastic 10.0
36 diabetes mellitus 10.0
37 lymphocytic leukemia 10.0
38 hallermann-streiff syndrome 9.9 IGF1 IGF2
39 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 9.9 IGF1 INSR
40 laron syndrome 9.9 IGF1 IGF2
41 sheehan syndrome 9.9 CRH IGF1 POMC
42 hypothyroidism, congenital, nongoitrous, 4 9.9 CRH IGF1 POMC
43 pituitary gland disease 9.9 CRH IGF1 POMC
44 cell type benign neoplasm 9.9 CRH IGF1 POMC
45 rubeosis iridis 9.9 IGF1 IGF2
46 hypopituitarism 9.9 CRH IGF1 POMC
47 chronic fatigue syndrome 9.9 CRH IGF1 POMC
48 gonadal disease 9.9 CRH IGF1 POMC
49 hypoadrenocorticism, familial 9.9 CRH POMC
50 donohue syndrome 9.9 IGF1 INSR

Graphical network of the top 20 diseases related to Fasting Hypoglycemia:



Diseases related to Fasting Hypoglycemia

Symptoms & Phenotypes for Fasting Hypoglycemia

GenomeRNAi Phenotypes related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

26 (show all 41)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.45 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.45 IGF1 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.45 IGF1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.45 IGF2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.45 GYS2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.45 POMC GYS2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.45 CD36
8 Increased shRNA abundance (Z-score > 2) GR00366-A-131 10.45 GYS2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.45 GYS2 IGF2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.45 IGF1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.45 GLP1R GYS2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.45 CD36 GLP1R
13 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.45 IGF1 GLP1R GYS2 IGF2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.45 IGF1 GYS2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.45 IGF1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.45 IGF2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.45 IGF1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.45 GLP1R
19 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.45 GYS2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.45 IGF2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.45 GYS2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.45 GYS2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-208 10.45 IGF1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.45 IGF1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.45 CD36
26 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.45 CD36 IGF1 POMC
27 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.45 CD36
28 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.45 POMC
29 Increased shRNA abundance (Z-score > 2) GR00366-A-4 10.45 CD36
30 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.45 CD36
31 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.45 GYS2
32 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.45 CD36
33 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.45 IGF2
34 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.45 IGF2
35 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.45 GLP1R
36 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.45 IGF2
37 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.45 IGF2
38 Increased shRNA abundance (Z-score > 2) GR00366-A-88 10.45 POMC
39 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.45 POMC
40 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.45 IGF1
41 Reduced mammosphere formation GR00396-S 9.02 GLP1R GYS2 IGF1 IGF2 POMC

MGI Mouse Phenotypes related to Fasting Hypoglycemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 CD36 CRH GLP1R GYS1 GYS2 IGF2
2 cardiovascular system MP:0005385 10.03 ACADM CD36 GYS1 GYS2 IGF1 IGF2
3 cellular MP:0005384 10.01 CD36 CRH GYS1 GYS2 IGF1 IGF2
4 homeostasis/metabolism MP:0005376 10 ACADM CD36 CRH GLP1R GLUD1 GYS1
5 endocrine/exocrine gland MP:0005379 9.97 CD36 CRH GLP1R GLUD1 IGF1 IGF2
6 growth/size/body region MP:0005378 9.97 CD36 CRH GLP1R GLUD1 GYS1 IGF1
7 adipose tissue MP:0005375 9.95 CD36 CRH GLP1R IGF1 INSR POMC
8 liver/biliary system MP:0005370 9.76 ACADM CD36 CRH GYS1 GYS2 IGF2
9 muscle MP:0005369 9.5 ACADM CD36 GYS1 GYS2 IGF1 IGF2
10 renal/urinary system MP:0005367 9.1 CD36 CRH IGF1 IGF2 INSR POMC

Drugs & Therapeutics for Fasting Hypoglycemia

Drugs for Fasting Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Non Invasive Assessment of Liver Glycogen Kinetics and ATP Synthesis in Type1 Diabetics Completed NCT00481598 Not Applicable
2 Diagnosing and Treating Low Blood Sugar Levels Recruiting NCT00001276

Search NIH Clinical Center for Fasting Hypoglycemia

Genetic Tests for Fasting Hypoglycemia

Anatomical Context for Fasting Hypoglycemia

MalaCards organs/tissues related to Fasting Hypoglycemia:

41
Endothelial, Cortex, Liver, Pituitary, Pancreas, Adrenal Gland, Adrenal Cortex

Publications for Fasting Hypoglycemia

Articles related to Fasting Hypoglycemia:

(show top 50) (show all 58)
# Title Authors Year
1
Severe fasting hypoglycemia in a child after total pancreatectomy with islet autotransplantation. ( 29139589 )
2018
2
Fasting hypoglycemia is associated with disease progression in presymptomatic early stage type 1 diabetes. ( 30098103 )
2018
3
An unusual presentation of post gastric bypass hypoglycemia with both postprandial and fasting hypoglycemia ( 30427165 )
2018
4
Fasting Hypoglycemia on (18)F-FDG PET/CT Scan. ( 28420855 )
2017
5
Intractable Fasting Hypoglycemia as a Manifestation of Hepatocellular Carcinoma. ( 28785493 )
2017
6
Hypothalamic glucagon signaling in fasting hypoglycemia. ( 27084528 )
2016
7
Erratum to "Hypothalamic glucagon signaling in fasting hypoglycemia" [Life Sci. 153 (2016) 118-123]. ( 27569756 )
2016
8
Sexual Dimorphism in Glucose and Lipid Metabolism during Fasting, Hypoglycemia, and Exercise. ( 25964778 )
2015
9
The association between fasting hypoglycemia and methylated mercaptopurine metabolites in children with acute lymphoblastic leukemia. ( 24415675 )
2014
10
Basal Insulin Use in the Non-Critical Care Setting: Is Fasting Hypoglycemia Inevitable or Preventable? ( 24876599 )
2014
11
Aromatic L-amino acid decarboxylase deficiency is a cause of long-fasting hypoglycemia. ( 24037885 )
2013
12
CD36 deficiency predisposing young children to fasting hypoglycemia. ( 20947105 )
2011
13
Poor specificity of low growth hormone and cortisol levels during fasting hypoglycemia for the diagnoses of growth hormone deficiency and adrenal insufficiency. ( 18694902 )
2008
14
Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion. ( 18635551 )
2008
15
Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency. ( 16239968 )
2005
16
Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. ( 15031319 )
2004
17
Fasting hypoglycemia in solitary fibrous tumor of the peritoneum: a diagnostic clue for an emergent situation. ( 15290507 )
2003
18
The diagnosis of fasting hypoglycemia due to an islet-cell tumor obscured by a highly specific insulin assay. ( 12679423 )
2003
19
Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia. ( 11372615 )
2001
20
Protein-sensitive and fasting hypoglycemia in children with the hyperinsulinism/hyperammonemia syndrome. ( 11241047 )
2001
21
Fasting hypoglycemia is common during maintenance therapy for childhood acute lymphoblastic leukemia. ( 11241057 )
2001
22
Primary malignant fibrous histiocytoma of the lung: IGF-II producing tumor induces fasting hypoglycemia. ( 11149628 )
2000
23
Anti-insulin receptor autoantibodies in a patient with type B insulin resistance and fasting hypoglycemia. ( 11450502 )
2000
24
Severe and recurrent fasting hypoglycemia due to growth hormone deficiency? ( 10493328 )
1999
25
[Peripheral plasma corticotropin-releasing hormone (CRH) in an aged patient with fasting hypoglycemia associated with an insufficient secretion of insulin: an implication of plasma CRH in glucose metabolism]. ( 7556777 )
1995
26
Mechanisms of fasting hypoglycemia and concomitant insulin resistance in insulinoma patients. ( 8446044 )
1993
27
Effect of insulin-induced and fasting hypoglycemia on perinatal hypoxic-ischemic brain damage. ( 1542541 )
1992
28
A practical approach to fasting hypoglycemia. ( 1545839 )
1992
29
A glucose reduction challenge in the differential diagnosis of fasting hypoglycemia: a two-center study. ( 2407752 )
1990
30
Hyperinsulinemia due to impaired insulin clearance associated with fasting hypoglycemia and postprandial hyperglycemia: an analysis of a patient with antiinsulin receptor antibodies. ( 2668322 )
1989
31
Adult nesidioblastosis. An unusual cause of fasting hypoglycemia. ( 2729774 )
1989
32
Prolonged fasting hypoglycemia due to insulin antibodies in patient with non-insulin-dependent diabetes mellitus: effect of insulin withdrawal on insulin-antibody-binding kinetics. ( 3582076 )
1987
33
Idiopathic fasting hypoglycemia in an adult. ( 3812525 )
1987
34
Fasting hypoglycemia. ( 6870429 )
1983
35
Fasting hypoglycemia associated with disopyramide. ( 6356848 )
1983
36
Hypoketonemia and age-related fasting hypoglycemia in growth hormone deficiency. ( 6341760 )
1983
37
Clinicopathologic Conference. Intra-abdominal malignancy and fasting hypoglycemia. ( 7124779 )
1982
38
Fasting hypoglycemia in adults. ( 6279046 )
1982
39
Fasting hypoglycemia resulting from hepatic carnitine palmitoyl transferase deficiency. ( 7014807 )
1981
40
Fasting hypoglycemia secondary to disopyramide therapy. Report of two cases. ( 6785461 )
1981
41
Glycemic response to glucagon during fasting hypoglycemia: an aid in the diagnosis of hyperinsulinism. ( 7351590 )
1980
42
Fasting hypoglycemia in a pup. ( 689974 )
1978
43
Spontaneous fasting hypoglycemia: basal levels of plasma free fatty acids and glycerol, blood ketone bodies, serum cholesterol and plasma growth hormone. ( 668979 )
1978
44
Fasting hypoglycemia in a pup. ( 730606 )
1978
45
An insulinoma without fasting hypoglycemia. ( 188337 )
1976
46
Fasting hypoglycemia. A clinicopathologic conference from Veterans Administration Hospital Hines, Illinois. ( 177961 )
1976
47
Hyperinsulinism in infancy: diagnosis by demonstration of abnormal response to fasting hypoglycemia. ( 940710 )
1976
48
The diagnosis of insulinomas and other causes of fasting hypoglycemia. ( 179928 )
1976
49
Fasting hypoglycemia in adults. ( 176582 )
1976
50
Hypoglycemia: Clinical implications. Part II: Fasting hypoglycemia. ( 1115649 )
1975

Variations for Fasting Hypoglycemia

Expression for Fasting Hypoglycemia

Search GEO for disease gene expression data for Fasting Hypoglycemia.

Pathways for Fasting Hypoglycemia

Pathways related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 GYS1 GYS2 IGF1 INSR
2
Show member pathways
12.56 GYS1 GYS2 IGF1 IGF2 INSR
3
Show member pathways
12.29 GYS1 GYS2 IGF1 IGF2 INSR
4
Show member pathways
12.14 CRH GLP1R INSR
5
Show member pathways
12.12 GYS1 IGF1 IGF2
6
Show member pathways
11.87 GYS1 GYS2 INSR
7 11.74 CRH GLP1R POMC
8
Show member pathways
11.51 GYS1 GYS2 POMC
9
Show member pathways
11.44 CD36 GYS1 GYS2 IGF1 INSR
10
Show member pathways
11.29 CD36 GYS1 GYS2 INSR
11 11.12 IGF1 INSR
12 11.09 GYS1 GYS2
13
Show member pathways
10.99 GYS1 GYS2
14 10.96 GYS1 INSR
15
Show member pathways
10.89 IGF1 IGF2
16 10.76 IGF1 IGF2
17 10.1 CRH POMC

GO Terms for Fasting Hypoglycemia

Biological processes related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.83 CRH IGF1 IGF2 INSR
2 positive regulation of protein phosphorylation GO:0001934 9.67 CRH IGF2 INSR
3 platelet degranulation GO:0002576 9.61 CD36 IGF1 IGF2
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.58 CD36 IGF1 IGF2
5 activation of protein kinase B activity GO:0032148 9.56 IGF1 INSR
6 positive regulation of MAPK cascade GO:0043410 9.56 CD36 IGF1 IGF2 INSR
7 positive regulation of glucose import GO:0046326 9.55 IGF1 INSR
8 cellular response to amyloid-beta GO:1904646 9.54 CD36 IGF1
9 positive regulation of activated T cell proliferation GO:0042104 9.51 IGF1 IGF2
10 adrenal gland development GO:0030325 9.48 CRH INSR
11 positive regulation of glycolytic process GO:0045821 9.46 IGF1 INSR
12 response to sucrose GO:0009744 9.37 GYS1 GYS2
13 positive regulation of mitotic nuclear division GO:0045840 9.33 IGF1 IGF2 INSR
14 exocrine pancreas development GO:0031017 9.32 IGF2 INSR
15 glycogen biosynthetic process GO:0005978 9.13 ACADM GYS1 GYS2
16 positive regulation of glycogen biosynthetic process GO:0045725 8.8 IGF1 IGF2 INSR

Molecular functions related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.37 IGF1 IGF2
2 glucose binding GO:0005536 9.32 GYS1 GYS2
3 glycogen (starch) synthase activity GO:0004373 9.26 GYS1 GYS2
4 hormone activity GO:0005179 9.26 CRH IGF1 IGF2 POMC
5 glycogen synthase activity, transferring glucose-1-phosphate GO:0061547 9.16 GYS1 GYS2
6 insulin-like growth factor receptor binding GO:0005159 8.8 IGF1 IGF2 INSR

Sources for Fasting Hypoglycemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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