MCID: FST010
MIFTS: 35

Fasting Hypoglycemia

Categories: Rare diseases

Aliases & Classifications for Fasting Hypoglycemia

MalaCards integrated aliases for Fasting Hypoglycemia:

Name: Fasting Hypoglycemia 52 71

Classifications:



External Ids:

UMLS 71 C0271708

Summaries for Fasting Hypoglycemia

MalaCards based summary : Fasting Hypoglycemia is related to glycogen storage disease type 0 and potter's syndrome. An important gene associated with Fasting Hypoglycemia is ACADM (Acyl-CoA Dehydrogenase Medium Chain), and among its related pathways/superpathways are PI3K-Akt signaling pathway and NFAT and Cardiac Hypertrophy. The drugs Metformin and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, liver and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Fasting Hypoglycemia

Diseases related to Fasting Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 glycogen storage disease type 0 30.3 GYS2 GYS1
2 potter's syndrome 29.6 IGF2 IGF1
3 glycogen storage disease 29.4 IGF2 IGF1 GYS2 GYS1
4 hyperglycemia 29.1 INSR IGF1 GYS1 GLP1R
5 hyperinsulinemic hypoglycemia 29.0 INSR IGF2 GLUD1
6 islet cell tumor 29.0 INSR IGF2 IGF1
7 insulin-like growth factor i 28.7 INSR IGF2 IGF1
8 hyperinsulinism 28.7 INSR IGF2 IGF1 GYS1 GLUD1
9 hypoglycemia 27.2 POMC INSR IGF2 IGF1 GYS2 GYS1
10 glycogen storage disease 0, liver 11.4
11 acyl-coa dehydrogenase, medium-chain, deficiency of 11.2
12 phosphoenolpyruvate carboxykinase deficiency, cytosolic 11.2
13 glycogen storage disease 0, muscle 11.2
14 3-hydroxyacyl-coa dehydrogenase deficiency 10.2 GLUD1 ACADM
15 insulinoma 10.2
16 acth-dependent cushing syndrome 10.2 POMC CRH
17 hypoadrenalism 10.1 POMC CRH
18 ectopic cushing syndrome 10.1 POMC CRH
19 atypical depressive disorder 10.1 POMC CRH
20 pituitary-dependent cushing's disease 10.1 POMC CRH
21 gangliocytoma 10.1 POMC CRH
22 nelson syndrome 10.1 POMC CRH
23 acth deficiency, isolated 10.1 POMC CRH
24 acute stress disorder 10.1 POMC CRH
25 carbohydrate metabolic disorder 10.1 GYS2 GYS1 GLUD1
26 growth hormone deficiency 10.1
27 acth-secreting pituitary adenoma 10.0 POMC CRH
28 melancholia 10.0 POMC CRH
29 pituitary carcinoma 10.0 POMC CRH
30 functionless pituitary adenoma 10.0 POMC IGF1
31 acidophil adenoma 10.0 POMC IGF1
32 hormone producing pituitary cancer 10.0 POMC IGF1
33 adrenal cortical hypofunction 10.0 POMC CRH
34 pituitary apoplexy 10.0 POMC IGF1
35 spinocerebellar degeneration 10.0 GLUD1 CRH CD36
36 leukemia, acute lymphoblastic 10.0
37 lymphocytic leukemia 10.0
38 aromatase excess syndrome 10.0 POMC IGF1
39 lipoid congenital adrenal hyperplasia 10.0 POMC CRH ACADM
40 intracranial hypertension, idiopathic 9.9 POMC IGF1
41 empty sella syndrome 9.9 POMC IGF1
42 withdrawal disorder 9.9 POMC CRH
43 olivopontocerebellar atrophy 9.9 GLUD1 CRH
44 acid-labile subunit deficiency 9.9 IGF2 IGF1
45 growth hormone secreting pituitary adenoma 9.9 POMC IGF1
46 pituitary tumors 9.8 POMC IGF1
47 hepatocellular carcinoma 9.8
48 multiple endocrine neoplasia, type i 9.8
49 carnitine palmitoyltransferase i deficiency 9.8
50 hyperinsulinemic hypoglycemia, familial, 6 9.8

Graphical network of the top 20 diseases related to Fasting Hypoglycemia:



Diseases related to Fasting Hypoglycemia

Symptoms & Phenotypes for Fasting Hypoglycemia

GenomeRNAi Phenotypes related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.89 IGF1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.89 IGF1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.89 IGF2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.89 GYS2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.89 GYS2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.89 GYS2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.89 GYS2 IGF2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.89 IGF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-144 9.89 IGF1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.89 GLP1R GYS2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.89 GLP1R
12 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.89 GLP1R GYS2 IGF1 IGF2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.89 GYS2 IGF1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.89 IGF1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.89 IGF2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.89 IGF1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.89 GLP1R
18 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.89 GYS2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.89 GYS2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.89 IGF1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.89 GYS2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.89 IGF1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.89 IGF1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.89 GLP1R
25 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.89 IGF1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.89 GYS2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.89 IGF2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.89 IGF2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.89 GLP1R
30 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.89 IGF2
31 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.89 IGF1

MGI Mouse Phenotypes related to Fasting Hypoglycemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 CD36 CRH GLP1R GYS1 GYS2 IGF2
2 cellular MP:0005384 10.06 AQP7 CD36 CRH GYS1 GYS2 IGF1
3 cardiovascular system MP:0005385 10.03 ACADM CD36 GYS1 GYS2 IGF1 IGF2
4 homeostasis/metabolism MP:0005376 10.03 ACADM AQP7 CD36 CRH GLP1R GLUD1
5 adipose tissue MP:0005375 10.02 AQP7 CD36 CRH GLP1R IGF1 INSR
6 endocrine/exocrine gland MP:0005379 10.02 AQP7 CD36 CRH GLP1R GLUD1 IGF1
7 growth/size/body region MP:0005378 10.02 AQP7 CD36 CRH GLP1R GLUD1 GYS1
8 liver/biliary system MP:0005370 9.76 ACADM CD36 CRH GYS1 GYS2 IGF2
9 muscle MP:0005369 9.5 ACADM CD36 GYS1 GYS2 IGF1 IGF2
10 renal/urinary system MP:0005367 9.17 AQP7 CD36 CRH IGF1 IGF2 INSR

Drugs & Therapeutics for Fasting Hypoglycemia

Drugs for Fasting Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Nitric Oxide Approved Phase 4 10102-43-9 145068
3 Incretins Phase 4
4 HIV Protease Inhibitors Phase 4
5 Hypoglycemic Agents Phase 4
6
protease inhibitors Phase 4
7 Hormone Antagonists Phase 4
8 Sitagliptin Phosphate Phase 4
9 Dipeptidyl-Peptidase IV Inhibitors Phase 4
10 Hormones Phase 4
11 Glucagon-Like Peptide 1 Phase 2
12
Glucagon Approved Phase 1 16941-32-5
13
Somatostatin Approved, Investigational Phase 1 51110-01-1, 38916-34-6 53481605
14
Octreotide Approved, Investigational Phase 1 83150-76-9 383414 6400441
15
Pasireotide Approved Phase 1 396091-73-9 9941444
16
Lactitol Investigational Phase 1 585-86-4, 585-88-6 493591
17 insulin Phase 1
18 Insulin, Globin Zinc Phase 1
19 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Crossover Design Study of Acute and Chronic Effects of Sitagliptin on Endothelial Function in Humans With Type 2 Diabetes on Background Metformin Completed NCT01859793 Phase 4 sitagliptin;Placebo
2 The Effects of the DPPIV Inhibitor Sitagliptin in Cystic Fibrosis-related Diabetes Terminated NCT01257464 Phase 2 Sitagliptin;Placebo
3 Treatment Plan for an Individual Patient With Pasireotide for Hyperinsulinemic Hypoglycemia Recruiting NCT03103009 Phase 1 Pasireotide
4 Testing Glial Pathways to HAAF in Human Subjects Using Carbon 13 Magnetic Resonance Spectroscopy Completed NCT02690168
5 Fasting Hypoglycemia: Diagnosis and Treatment Recruiting NCT00001276
6 Mini-Dose Glucagon to Treat Fasting-induced Hypoglycemia During Ramadan Recruiting NCT03970772 Glucagon Injection
7 The Effect of Gastric Bypass Surgery on Glucose Metabolism, Gestational Weight Gain and Fetal Growth in Subsequent Pregnancy Recruiting NCT03713060
8 Application of Novel Techniques to Devise Nutritional Therapies in Subjects With Glycogen Storage Disease Type I Recruiting NCT03218904

Search NIH Clinical Center for Fasting Hypoglycemia

Genetic Tests for Fasting Hypoglycemia

Anatomical Context for Fasting Hypoglycemia

MalaCards organs/tissues related to Fasting Hypoglycemia:

40
Pituitary, Liver, Testes, Pancreas, Endothelial, Brain, Skeletal Muscle

Publications for Fasting Hypoglycemia

Articles related to Fasting Hypoglycemia:

(show top 50) (show all 371)
# Title Authors PMID Year
1
Long-term metabolic consequences of acute dioxin exposure differ between male and female mice. 61
31996693 2020
2
Fasting- Evoked En route Hypoglycemia in Diabetes (FEEHD): From guidelines to clinical practice. 61
31914915 2020
3
Insulinoma Case Admitted with Reactive Hypoglycemia Symptoms. 61
31544700 2019
4
Attitude and safety of patients with diabetes observing the Ramadan fast. 61
30946851 2019
5
Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes. 61
31178432 2019
6
Uniparental isodisomy of chromosome 1 results in glycogen storage disease type III with profound growth retardation. 61
30916492 2019
7
Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia. 61
31033478 2019
8
Enhancement of postprandial endogenous insulin secretion rather than exogenous insulin injection ameliorated insulin antibody-induced unstable diabetes: a case report. 61
30621663 2019
9
GLUCOSE CHANGES IN A PATIENT WITH INSULIN AUTOIMMUNE SYNDROME DEMONSTRATED BY CONTINUOUS GLUCOSE MONITORING. 61
31966997 2019
10
Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia. 61
30828444 2019
11
Feasibility study of metabolically supported chemotherapy with weekly carboplatin/paclitaxel combined with ketogenic diet, hyperthermia and hyperbaric oxygen therapy in metastatic non-small cell lung cancer. 61
30931666 2019
12
The role of vasodilator-stimulated phosphoprotein (VASP) in the control of hepatic gluconeogenic gene expression. 61
31017943 2019
13
Insulin autoimmune syndrome: Three case reports. 61
30572448 2018
14
Hypoglycemia Unawareness in Insulinoma Revealed with Flash Glucose Monitoring Systems. 61
30101920 2018
15
Fasting hypoglycemia is associated with disease progression in presymptomatic early stage type 1 diabetes. 61
30098103 2018
16
An open-label pilot study on preventing glucocorticoid-induced diabetes mellitus with linagliptin. 61
30285859 2018
17
An unusual presentation of post gastric bypass hypoglycemia with both postprandial and fasting hypoglycemia 61
30427165 2018
18
Multicentric insulinoma associated with multiple endocrine neoplasia type 1: One case report 61
30394721 2018
19
Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases. 61
29784585 2018
20
Treatment with medium chain fatty acids milk of CD36-deficient preschool children. 61
29524782 2018
21
[Molecular and clinical characterization of Colombian patients suffering from type III glycogen storage disease]. 61
29809327 2018
22
Implementation of Low Glycemic Index Diet Together with Cornstarch in Post-Gastric Bypass Hypoglycemia: Two Case Reports. 61
29799438 2018
23
Late presentation of glycogen storage disease types Ia and III in children with short stature and hepatomegaly. 61
29374762 2018
24
G6PC mRNA Therapy Positively Regulates Fasting Blood Glucose and Decreases Liver Abnormalities in a Mouse Model of Glycogen Storage Disease 1a. 61
29428299 2018
25
Glycosuria and hyperglycemia in the neonatal period as the first clinical sign of Fanconi-Bickel syndrome. 61
28493372 2018
26
Severe fasting hypoglycemia in a child after total pancreatectomy with islet autotransplantation. 61
29139589 2018
27
Donohue syndrome: A review of literature, case series, and anesthetic considerations. 61
29148123 2018
28
INSR-Related Severe Syndromic Insulin Resistance 61
29369573 2018
29
Fluctuation of blood glucose levels in an infant with an ileostomy on continuous glucose monitoring: A case report. 61
29403155 2018
30
Glycogen storage disease type 0 due to a novel frameshift mutation in glycogen synthase 2 (GYS2) gene in a child presenting with fasting hypoglycemia and postprandial hyperglycemia. 61
30968641 2018
31
Diabetes mellitus in a patient with glycogen storage disease type Ia: a case report. 61
29127952 2017
32
Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia. 61
28911206 2017
33
High glycated albumin (GA) levels and the GA/HbA1c ratio in patients with insulin autoimmune syndrome. 61
30603322 2017
34
The variable clinical phenotype of three patients with hepatic glycogen synthase deficiency. 61
28245189 2017
35
Intractable Fasting Hypoglycemia as a Manifestation of Hepatocellular Carcinoma. 61
28785493 2017
36
Paroxysmal Hypertension Induced by an Insulinoma. 61
28202863 2017
37
The coexistence of hypercalcemia and hypoglycemia in a patient with a renal tumor and B cell lymphoma. 61
27737327 2017
38
Fasting Hypoglycemia on 18F-FDG PET/CT Scan. 61
28420855 2017
39
GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states. 61
27550964 2016
40
Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance. 61
27528620 2016
41
Expanding the molecular diversity and phenotypic spectrum of glycerol 3-phosphate dehydrogenase 1 deficiency. 61
27368975 2016
42
Fanconi Bickel Syndrome with Hypercalciuria due to GLUT 2 Mutation. 61
27771652 2016
43
Progressive development of renal cysts in glycogen storage disease type I. 61
27436577 2016
44
Erratum to "Hypothalamic glucagon signaling in fasting hypoglycemia" [Life Sci. 153 (2016) 118-123]. 61
27569756 2016
45
Spectrum of AGL mutations in Chinese patients with glycogen storage disease type III: identification of 31 novel mutations. 61
26984562 2016
46
Hypothalamic glucagon signaling in fasting hypoglycemia. 61
27084528 2016
47
Hypoglycemic Syndrome without Hyperinsulinemia. A Diagnostic Challenge. 61
26801953 2016
48
Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy. 61
26696124 2016
49
Estimation of glucose utilization in a type 2 diabetes mellitus patient on insulin analogs with tumor hypoglycemia induced by IGF-II. 61
26774399 2016
50
The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity. 61
26455881 2016

Variations for Fasting Hypoglycemia

Expression for Fasting Hypoglycemia

Search GEO for disease gene expression data for Fasting Hypoglycemia.

Pathways for Fasting Hypoglycemia

Pathways related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 INSR IGF2 IGF1 GYS2 GYS1
2
Show member pathways
12.29 INSR IGF2 IGF1 GYS2 GYS1
3
Show member pathways
11.89 INSR GYS2 GYS1
4 11.77 POMC GLP1R CRH
5
Show member pathways
11.55 POMC GYS2 GYS1
6
Show member pathways
11.43 INSR IGF1 GYS2 GYS1 CD36
7 11.38 CD36 AQP7 ACADM
8
Show member pathways
11.3 INSR GYS2 GYS1 CD36
9
Show member pathways
11 GYS2 GYS1
10 10.97 INSR GYS1
11
Show member pathways
10.91 IGF2 IGF1
12 10.78 IGF2 IGF1
13 10.1 POMC CRH

GO Terms for Fasting Hypoglycemia

Biological processes related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.81 INSR IGF2 IGF1 CRH
2 positive regulation of protein phosphorylation GO:0001934 9.67 INSR IGF2 CRH
3 platelet degranulation GO:0002576 9.58 IGF2 IGF1 CD36
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.54 IGF2 IGF1 CD36
5 activation of protein kinase B activity GO:0032148 9.52 INSR IGF1
6 positive regulation of activated T cell proliferation GO:0042104 9.48 IGF2 IGF1
7 positive regulation of glycolytic process GO:0045821 9.46 INSR IGF1
8 positive regulation of MAPK cascade GO:0043410 9.46 INSR IGF2 IGF1 CD36
9 adrenal gland development GO:0030325 9.43 INSR CRH
10 positive regulation of mitotic nuclear division GO:0045840 9.43 INSR IGF2 IGF1
11 exocrine pancreas development GO:0031017 9.32 INSR IGF2
12 glycogen biosynthetic process GO:0005978 9.13 GYS2 GYS1 ACADM
13 positive regulation of glycogen biosynthetic process GO:0045725 8.8 INSR IGF2 IGF1

Molecular functions related to Fasting Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.32 IGF2 IGF1
2 glycogen (starch) synthase activity GO:0004373 9.26 GYS2 GYS1
3 hormone activity GO:0005179 9.26 POMC IGF2 IGF1 CRH
4 glycogen synthase activity, transferring glucose-1-phosphate GO:0061547 9.16 GYS2 GYS1
5 insulin-like growth factor receptor binding GO:0005159 8.8 INSR IGF2 IGF1

Sources for Fasting Hypoglycemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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