FGQTL1
MCID: FST012
MIFTS: 13

Fasting Plasma Glucose Level Quantitative Trait Locus 1 (FGQTL1)

Categories: Genetic diseases

Aliases & Classifications for Fasting Plasma Glucose Level Quantitative Trait Locus 1

MalaCards integrated aliases for Fasting Plasma Glucose Level Quantitative Trait Locus 1:

Name: Fasting Plasma Glucose Level Quantitative Trait Locus 1 56 29 6
Fasting Plasma Glucose Level Qtl 1 56 13
Fgqtl1 56

Classifications:



External Ids:

OMIM 56 612108

Summaries for Fasting Plasma Glucose Level Quantitative Trait Locus 1

OMIM : 56 Glucose is the major source of energy in humans, with levels in vivo determined by a balance of glucose absorption via the gut, production primarily by the liver, and utilization by both insulin-sensitive and insulin-insensitive tissues. Blood and plasma fasting glucose levels are tightly regulated within a narrow physiologic range by a feedback mechanism that targets a particular fasting glucose set point for each individual. Within healthy, nondiabetic populations there is substantial variation in fasting glucose levels. Approximately one-third of this variation is genetic. Disruption of normal glucose homeostasis and substantial elevations of fasting glucose are hallmarks of type 2 diabetes (T2D) and typically result from sustained reduction in pancreatic beta-cell function and insulin secretion (summary by Chen et al., 2008 and Prokopenko et al., 2009). (612108)

MalaCards based summary : Fasting Plasma Glucose Level Quantitative Trait Locus 1, also known as fasting plasma glucose level qtl 1, is related to fasting plasma glucose level quantitative trait locus 2. An important gene associated with Fasting Plasma Glucose Level Quantitative Trait Locus 1 is FGQTL1 (Fasting Plasma Glucose Level QTL 1). Affiliated tissues include liver.

Related Diseases for Fasting Plasma Glucose Level Quantitative Trait Locus 1

Symptoms & Phenotypes for Fasting Plasma Glucose Level Quantitative Trait Locus 1

Clinical features from OMIM:

612108

Drugs & Therapeutics for Fasting Plasma Glucose Level Quantitative Trait Locus 1

Search Clinical Trials , NIH Clinical Center for Fasting Plasma Glucose Level Quantitative Trait Locus 1

Genetic Tests for Fasting Plasma Glucose Level Quantitative Trait Locus 1

Genetic tests related to Fasting Plasma Glucose Level Quantitative Trait Locus 1:

# Genetic test Affiliating Genes
1 Fasting Plasma Glucose Level Quantitative Trait Locus 1 29

Anatomical Context for Fasting Plasma Glucose Level Quantitative Trait Locus 1

MalaCards organs/tissues related to Fasting Plasma Glucose Level Quantitative Trait Locus 1:

40
Liver

Publications for Fasting Plasma Glucose Level Quantitative Trait Locus 1

Articles related to Fasting Plasma Glucose Level Quantitative Trait Locus 1:

(showing 4, show less)
# Title Authors PMID Year
1
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. 56
20081858 2010
2
Variants in MTNR1B influence fasting glucose levels. 56
19060907 2009
3
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. 56
18521185 2008
4
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. 56
18451265 2008

Variations for Fasting Plasma Glucose Level Quantitative Trait Locus 1

ClinVar genetic disease variations for Fasting Plasma Glucose Level Quantitative Trait Locus 1:

6 (showing 1, show less) ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 G6PC2 NM_021176.3(G6PC2):c.847C>T (p.Arg283Ter)SNV Uncertain significance 548513 rs146779637 2:169764368-169764368 2:168907858-168907858

Expression for Fasting Plasma Glucose Level Quantitative Trait Locus 1

Search GEO for disease gene expression data for Fasting Plasma Glucose Level Quantitative Trait Locus 1.

Pathways for Fasting Plasma Glucose Level Quantitative Trait Locus 1

GO Terms for Fasting Plasma Glucose Level Quantitative Trait Locus 1

Sources for Fasting Plasma Glucose Level Quantitative Trait Locus 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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