FGQTL5
MCID: FST017
MIFTS: 12

Fasting Plasma Glucose Level Quantitative Trait Locus 5 (FGQTL5)

Categories: Genetic diseases

Aliases & Classifications for Fasting Plasma Glucose Level Quantitative Trait Locus 5

MalaCards integrated aliases for Fasting Plasma Glucose Level Quantitative Trait Locus 5:

Name: Fasting Plasma Glucose Level Quantitative Trait Locus 5 57 29 6 39
Fasting Plasma Glucose Level Qtl 5 57
Fgqtl5 57

Classifications:



External Ids:

OMIM® 57 613463

Summaries for Fasting Plasma Glucose Level Quantitative Trait Locus 5

MalaCards based summary : Fasting Plasma Glucose Level Quantitative Trait Locus 5, is also known as fasting plasma glucose level qtl 5. An important gene associated with Fasting Plasma Glucose Level Quantitative Trait Locus 5 is GCKR (Glucokinase Regulator).

More information from OMIM: 613463

Related Diseases for Fasting Plasma Glucose Level Quantitative Trait Locus 5

Symptoms & Phenotypes for Fasting Plasma Glucose Level Quantitative Trait Locus 5

Clinical features from OMIM®:

613463 (Updated 20-May-2021)

Drugs & Therapeutics for Fasting Plasma Glucose Level Quantitative Trait Locus 5

Search Clinical Trials , NIH Clinical Center for Fasting Plasma Glucose Level Quantitative Trait Locus 5

Genetic Tests for Fasting Plasma Glucose Level Quantitative Trait Locus 5

Genetic tests related to Fasting Plasma Glucose Level Quantitative Trait Locus 5:

# Genetic test Affiliating Genes
1 Fasting Plasma Glucose Level Quantitative Trait Locus 5 29 GCKR

Anatomical Context for Fasting Plasma Glucose Level Quantitative Trait Locus 5

Publications for Fasting Plasma Glucose Level Quantitative Trait Locus 5

Articles related to Fasting Plasma Glucose Level Quantitative Trait Locus 5:

(showing 9, show less)
# Title Authors PMID Year
1
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. 6 57
20081858 2010
2
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. 57 6
19643913 2009
3
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. 6 57
18678614 2008
4
The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. 57 6
18556336 2008
5
Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes. 6
22182842 2012
6
The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. 57
20574426 2010
7
Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. 57
18477659 2008
8
The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. 57
18008060 2008
9
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. 57
17463246 2007

Variations for Fasting Plasma Glucose Level Quantitative Trait Locus 5

ClinVar genetic disease variations for Fasting Plasma Glucose Level Quantitative Trait Locus 5:

6 (showing 3, show less)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 GCKR NM_001486.4(GCKR):c.1337T>C (p.Leu446Pro) SNV association 8751 rs1260326 GRCh37: 2:27730940-27730940
GRCh38: 2:27508073-27508073
2 GCKR NM_001486.4(GCKR):c.307G>A (p.Val103Met) SNV Likely pathogenic 225370 rs146175795 GRCh37: 2:27721143-27721143
GRCh38: 2:27498276-27498276
3 GCKR NM_001486.4(GCKR):c.230A>G (p.Glu77Gly) SNV Uncertain significance 225371 rs8179206 GRCh37: 2:27720442-27720442
GRCh38: 2:27497575-27497575

Expression for Fasting Plasma Glucose Level Quantitative Trait Locus 5

Search GEO for disease gene expression data for Fasting Plasma Glucose Level Quantitative Trait Locus 5.

Pathways for Fasting Plasma Glucose Level Quantitative Trait Locus 5

GO Terms for Fasting Plasma Glucose Level Quantitative Trait Locus 5

Sources for Fasting Plasma Glucose Level Quantitative Trait Locus 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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