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MCID: FTT001
MIFTS: 62

Fatty Liver Disease

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases, Metabolic diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Fatty Liver Disease

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MalaCards integrated aliases for Fatty Liver Disease:

Name: Fatty Liver Disease 12 42 15
Fatty Liver 74 54 6 44 71
Fatty Liver, Alcoholic 44 71
Alcoholic Fatty Liver 12 32
Fatty Change of Liver 12
Fatty Liver Alcoholic 54
Steatosis of Liver 12
Hepatic Lipidosis 12
Steatohepatitis 71

Classifications:

MalaCards categories:
Global: Metabolic diseases Cancer diseases
Anatomical: Gastrointestinal diseases Liver diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9452
ICD9CM 34 571.0
SNOMED-CT 67 371330000 50325005
ICD10 32 K70.0 K76.0
UMLS 71 C0015695 C0015696 C2711227
Sources

Summaries for Fatty Liver Disease

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MedlinePlus : 42 What is fatty liver disease? Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Fatty liver disease is a condition in which fat builds up in your liver. There are two main types: Nonalcoholic fatty liver disease (NAFLD) Alcoholic fatty liver disease, also called alcoholic steatohepatitis What is nonalcoholic fatty liver disease (NAFLD)? NAFLD is a type of fatty liver disease that is not related to heavy alcohol use. There are two kinds: Simple fatty liver, in which you have fat in your liver but little or no inflammation or liver cell damage. Simple fatty liver typically does not get bad enough to cause liver damage or complications. Nonalcoholic steatohepatitis (NASH), in which you have inflammation and liver cell damage, as well as fat in your liver. Inflammation and liver cell damage can cause fibrosis, or scarring, of the liver. NASH may lead to cirrhosis or liver cancer. What is alcoholic fatty liver disease? Alcoholic fatty liver disease is due to heavy alcohol use. Your liver breaks down most of the alcohol you drink, so it can be removed from your body. But the process of breaking it down can generate harmful substances. These substances can damage liver cells, promote inflammation, and weaken your body's natural defenses. The more alcohol that you drink, the more you damage your liver. Alcoholic fatty liver disease is the earliest stage of alcohol-related liver disease. The next stages are alcoholic hepatitis and cirrhosis. Who is at risk for fatty liver disease? The cause of nonalcoholic fatty liver disease (NAFLD) is unknown. Researchers do know that it is more common in people who Have type 2 diabetes and prediabetes Have obesity Are middle aged or older (although children can also get it) Are Hispanic, followed by non-Hispanic whites. It is less common in African Americans. Have high levels of fats in the blood, such as cholesterol and triglycerides Have high blood pressure Take certain drugs, such as corticosteroids and some cancer drugs Have certain metabolic disorders, including metabolic syndrome Have rapid weight loss Have certain infections, such as hepatitis C Have been exposed to some toxins NAFLD affects about 25 percent of people in the world. As the rates of obesity, type 2 diabetes, and high cholesterol are rising in the United States, so is the rate of NAFLD. NAFLD is the most common chronic liver disorder in the United States. Alcoholic fatty liver disease only happens in people who are heavy drinkers, especially those who have been drinking for a long period of time. The risk is higher for heavy drinkers who are women, have obesity, or have certain genetic mutations. What are the symptoms of fatty liver disease? Both NAFLD and alcoholic fatty liver disease are usually silent diseases with few or no symptoms. If you do have symptoms, you may feel tired or have discomfort in the upper right side of your abdomen. How is fatty liver disease diagnosed? Because there are often no symptoms, it is not easy to find fatty liver disease. Your doctor may suspect that you have it if you get abnormal results on liver tests that you had for other reasons. To make a diagnosis, your doctor will use Your medical history A physical exam Various tests, including blood and imaging tests, and sometimes a biopsy As part of the medical history, your doctor will ask about your alcohol use, to find out whether fat in your liver is a sign of alcoholic fatty liver disease or nonalcoholic fatty liver (NAFLD). He or she will also ask which medicines you take, to try to determine whether a medicine is causing your NAFLD. During the physical exam, your doctor will examine your body and check your weight and height. Your doctor will look for signs of fatty liver disease, such as An enlarged liver Signs of cirrhosis, such as jaundice, a condition that causes your skin and whites of your eyes to turn yellow You will likely have blood tests, including liver function tests and blood count tests. In some cases you may also have imaging tests, like those that check for fat in the liver and the stiffness of your liver. Liver stiffness can mean fibrosis, which is scarring of the liver. In some cases you may also need a liver biopsy to confirm the diagnosis, and to check how bad the liver damage is. What are the treatments for fatty liver disease? Doctors recommend weight loss for nonalcoholic fatty liver. Weight loss can reduce fat in the liver, inflammation, and fibrosis. If your doctor thinks that a certain medicine is the cause of your NAFLD, you should stop taking that medicine. But check with your doctor before stopping the medicine. You may need to get off the medicine gradually, and you might need to switch to another medicine instead. There are no medicines that have been approved to treat NAFLD. Studies are investigating whether a certain diabetes medicine or Vitamin E can help, but more studies are needed. The most important part of treating alcohol-related fatty liver disease is to stop drinking alcohol. If you need help doing that, you may want to see a therapist or participate in an alcohol recovery program. There are also medicines that can help, either by reducing your cravings or making you feel sick if you drink alcohol. Both alcoholic fatty liver disease and one type of nonalcoholic fatty liver disease (nonalcoholic steatohepatitis) can lead to cirrhosis. Doctors can treat the health problems caused by cirrhosis with medicines, operations, and other medical procedures. If the cirrhosis leads to liver failure, you may need a liver transplant. What are some lifestyle changes that can help with fatty liver disease? If you have any of the types of fatty liver disease, there are some lifestyle changes that can help: Eat a healthy diet, limiting salt and sugar, plus eating lots of fruits, vegetables, and whole grains Get vaccinations for hepatitis A and B, the flu and pneumococcal disease. If you get hepatitis A or B along with fatty liver, it is more likely to lead to liver failure. People with chronic liver disease are more likely to get infections, so the other two vaccinations are also important. Get regular exercise, which can help you lose weight and reduce fat in the liver Talk with your doctor before using dietary supplements, such as vitamins, or any complementary or alternative medicines or medical practices. Some herbal remedies can damage your liver.

MalaCards based summary : Fatty Liver Disease, also known as fatty liver, is related to non-alcoholic steatohepatitis and fatty liver disease, nonalcoholic 1. An important gene associated with Fatty Liver Disease is PRMT7 (Protein Arginine Methyltransferase 7), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and endothelial, and related phenotypes are homeostasis/metabolism and growth/size/body region

Disease Ontology : 12 A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis.

Wikipedia : 74 Fatty liver disease (FLD), also known as hepatic steatosis, is a condition where excess fat builds up in... more...

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Related Diseases for Fatty Liver Disease

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Diseases related to Fatty Liver Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 753)
# Related Disease Score Top Affiliating Genes
1 non-alcoholic steatohepatitis 33.2 TNF PPARA PNPLA3 MTTP LEPR INS
2 fatty liver disease, nonalcoholic 1 33.1 PRMT7 PNPLA3
3 liver disease 32.8 TNF SREBF1 SLC17A5 PPARA PNPLA3 MTTP
4 alcohol use disorder 32.6 SLC17A5 GPT GGT1 CYP2E1
5 non-alcoholic fatty liver disease 32.5 TNF SREBF1 PRMT7 PPARA PNPLA3 MTTP
6 hyperlipidemia, familial combined, 3 32.4 PPARA LEPR INS ADIPOQ
7 lipid metabolism disorder 32.2 SREBF1 PPARA MTTP LEP INSR INS
8 atherosclerosis susceptibility 32.1 TNF PPARA LEP INS IL6 ADIPOQ
9 viral hepatitis 32.0 TNF SLC17A5 PNPLA3 INS IL6 GPT
10 hyperuricemia 32.0 LEP INS GPT GGT1
11 hepatitis b 31.9 TNF SLC17A5 IL6 GPT GGT1
12 coronary heart disease 1 31.9 MTTP INS ADIPOQ
13 sleep apnea 31.8 TNF LEPR LEP INS IL6 GPT
14 polycystic ovary syndrome 31.8 LEP INSR INS ADIPOQ
15 hypothyroidism 31.8 TNF LEP INS GPT ADIPOQ
16 hyperinsulinism 31.8 SREBF1 PPARA LEPR LEP INSR INS
17 chronic kidney disease 31.7 TNF LEPR LEP INS IL6 FABP1
18 arteries, anomalies of 31.7 TNF LEP INS IL6 ADIPOQ
19 autoimmune hepatitis 31.7 TNF SLC17A5 GPT GGT1
20 portal hypertension 31.7 TNF PNPLA3 INS GPT
21 glucose intolerance 31.7 TNF LEPR LEP INSR INS IL6
22 leptin deficiency or dysfunction 31.7 TNF SREBF1 PPARA LEPR LEP INS
23 kidney disease 31.6 TNF LEP INS IL6 FABP1 ADIPOQ
24 lipoprotein quantitative trait locus 31.6 TNF PPARA INS IL6 GPT ADIPOQ
25 vascular disease 31.5 TNF LEP INS IL6 ADIPOQ
26 hyperglycemia 31.5 MALAT1 LEP INSR INS IL6 ADIPOQ
27 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 31.5 LEP INS ADIPOQ
28 liver cirrhosis 31.5 TNF SLC17A5 PNPLA3 MALAT1 LEPR LEP
29 proteasome-associated autoinflammatory syndrome 1 31.4 TNF PPARA INS IL6 ADIPOQ
30 disseminated intravascular coagulation 31.4 TNF IL6 GPT
31 heart disease 31.4 TNF PPARA LEP INSR INS IL6
32 cholangitis 31.4 TNF IL6 GPT GGT1
33 overnutrition 31.3 TNF SREBF1 PPARA LEPR LEP INS
34 hyperandrogenism 31.3 INSR INS ADIPOQ
35 alcoholic hepatitis 31.3 TNF SLC17A5 PNPLA3 IL6 GPT GGT1
36 cholelithiasis 31.3 LEP INS GPT
37 end stage renal disease 31.3 TNF LEP INS IL6 ADIPOQ
38 arteriosclerosis 31.3 PPARA INS IL6 GPT ADIPOQ
39 choline deficiency disease 31.3 SREBF1 PPARA GPT
40 gestational diabetes 31.3 TNF LEPR LEP INSR INS IL6
41 hepatic encephalopathy 31.2 TNF SLC17A5 IL6 GPT
42 alcohol dependence 31.2 TNF SLC17A5 LEP GGT1 CYP2E1
43 apnea, obstructive sleep 31.2 TNF LEP INS IL6 GPT ADIPOQ
44 wilson disease 31.2 TNF SLC17A5 PNPLA3 IL6 GPT
45 kwashiorkor 31.2 SLC17A5 INS GPT
46 sclerosing cholangitis 31.2 TNF IL6 GPT GGT1
47 cholangitis, primary sclerosing 31.2 TNF IL6 GPT GGT1
48 sleep disorder 31.2 TNF LEP INS IL6 ADIPOQ
49 acute pancreatitis 31.1 TNF INS IL6 GPT
50 diarrhea 31.1 TNF LEP IL6 GPT

Comorbidity relations with Fatty Liver Disease via Phenotypic Disease Network (PDN):


Alcoholic Hepatitis Alcoholic Liver Cirrhosis

Graphical network of the top 20 diseases related to Fatty Liver Disease:



Diseases related to Fatty Liver Disease
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Symptoms & Phenotypes for Fatty Liver Disease

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MGI Mouse Phenotypes related to Fatty Liver Disease:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 ADIPOQ ADIPOR2 CYP2E1 FABP1 GGT1 IL6
2 growth/size/body region MP:0005378 10.37 ADIPOQ ADIPOR2 CYP2E1 GGT1 IL6 INS
3 behavior/neurological MP:0005386 10.36 ADIPOQ ADIPOR2 CYP2E1 FABP1 GGT1 IL6
4 adipose tissue MP:0005375 10.34 ADIPOQ ADIPOR2 IL6 INS INSR LEP
5 cellular MP:0005384 10.3 ADIPOQ ADIPOR2 GGT1 IL6 INS INSR
6 cardiovascular system MP:0005385 10.28 ADIPOQ CYP2E1 IL6 INS INSR LEP
7 liver/biliary system MP:0005370 10.27 ADIPOQ ADIPOR2 CYP2E1 FABP1 IL6 INS
8 hematopoietic system MP:0005397 10.26 ADIPOQ ADIPOR2 FABP1 GGT1 IL6 INS
9 endocrine/exocrine gland MP:0005379 10.21 ADIPOQ ADIPOR2 GGT1 IL6 INS INSR
10 immune system MP:0005387 10.21 ADIPOQ ADIPOR2 FABP1 GGT1 IL6 INS
11 mortality/aging MP:0010768 10.17 ADIPOQ CYP2E1 GGT1 IL6 INS INSR
12 integument MP:0010771 10.06 ADIPOQ GGT1 IL6 INS LEP LEPR
13 muscle MP:0005369 9.91 ADIPOQ IL6 INS INSR LEP LEPR
14 neoplasm MP:0002006 9.7 ADIPOQ CYP2E1 IL6 LEP LEPR PRMT7
15 renal/urinary system MP:0005367 9.56 ADIPOQ GGT1 IL6 INS INSR LEP
16 skeleton MP:0005390 9.36 ADIPOQ ADIPOR2 CYP2E1 GGT1 GPT IL6
Sources

Drugs & Therapeutics for Fatty Liver Disease

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Drugs for Fatty Liver Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 377)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
2
Losartan Approved Phase 4 114798-26-4 3961
3
Atorvastatin Approved Phase 4 134523-00-5 60823
4
Milk thistle Approved, Experimental, Investigational Phase 4 65666-07-1
5
Glimepiride Approved Phase 4 93479-97-1 3476
6
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
7
Simvastatin Approved Phase 4 79902-63-9 54454
8
Amlodipine Approved Phase 4 88150-42-9 2162
9
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
10
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
11
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
12
Liraglutide Approved Phase 4 204656-20-2 44147092
13
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
14
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
15
Orlistat Approved, Investigational Phase 4 96829-58-2 3034010
16
Gliclazide Approved Phase 4 21187-98-4 3475
17
Insulin detemir Approved Phase 4 169148-63-4 5311023
18
Insulin aspart Approved Phase 4 116094-23-6 16132418
19
Phentermine Approved, Illicit Phase 4 122-09-8 4771
20
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
21
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
22
tannic acid Approved Phase 4 1401-55-4
23
Alogliptin Approved Phase 4 850649-61-5 11450633
24
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
25
Polyestradiol phosphate Approved Phase 4 28014-46-2
26
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
27
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
28
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
29
Empagliflozin Approved Phase 4 864070-44-0
30
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
31
Testosterone enanthate Approved Phase 4 315-37-7 9416
32
Testosterone Approved, Investigational Phase 4 58-22-0 6013
33
Methyltestosterone Approved Phase 4 58-18-4 6010
34
Dulaglutide Approved, Investigational Phase 4 923950-08-7
35
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
36
Zinc Approved, Investigational Phase 4 7440-66-6 32051
37
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
38
Metformin Approved Phase 4 657-24-9 14219 4091
39
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173 46783403
40
Insulin glargine Approved Phase 4 160337-95-1
41
Saxagliptin Approved Phase 4 361442-04-8 11243969
42
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
43
Ribavirin Approved Phase 4 36791-04-5 37542
44
Choline Approved, Nutraceutical Phase 4 62-49-7 305
45
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
46
Methionine Approved, Nutraceutical Phase 4 63-68-3 6137
47
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
48
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 6433735 5283731
49
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
50
Metadoxine Experimental Phase 4 74536-44-0

Interventional clinical trials:

(show top 50) (show all 1039)
# Name Status NCT ID Phase Drugs
1 Endobarrier Treatment in Obese Subjects With T2DM Unknown status NCT01718457 Phase 4
2 A Randomised Controlled Trial of Lifestyle Versus Ezetimibe Plus Lifestyle in Patients With Non-alcoholic Steatohepatitis Unknown status NCT01950884 Phase 4 Ezetimibe
3 Pleiotropic Effects and Safety of Sodium Glucose Co-transporter 2 Inhibitor Versus Sulfonylurea in Patients With Type 2 Diabetes and Non-alcoholic Fatty Liver Unknown status NCT02649465 Phase 4 Tofogliflozin;Glimepiride
4 Placebo Controlled Study Using Lovaza as Treatment for Non-Alcoholic Fatty Liver Disease Unknown status NCT00941642 Phase 4 Lovaza;placebo control
5 THE EFFECT OF DUAL TREATMENT WITH L-CARNITINE AND MAGNESIUM ON Patients With Non Alcoholic Fatty Liver Disease Unknown status NCT01956825 Phase 4
6 An Randomized Open Label Trial on the Impact of 24 Weeks of Atorvastatin Therapy on Liver Fat Content and Abdominal Fat Content in Patients With Type 2 Diabetes Combined With High LDL-C and Non-alcoholic Fatty Liver Disease Unknown status NCT01720719 Phase 4 atorvastatin;Vitamin E
7 Evaluation of Perindopril and Telmisartan for the Treatment of Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial Unknown status NCT02213224 Phase 4 Perindopril;Telmisartan;Amlodipine
8 Randomized Study Comparing Switching to Raltegravir-based Antiretroviral Versus Maintaining Any Other Antiretroviral Therapy in HIV Monoinfected Patients Impact on Fatty Liver and Liver Fibrosis Assessed by Noninvasive Diagnostic Methods Unknown status NCT02210715 Phase 4 Isentress.
9 Pilot Study to Assess the Antiviral Activity and Safety of Besifovir Dipivoxil 150mg and L-carnitine 660mg Compared to Tenofovir Alafenamide 25mg in Chronic Hepatitis B Patients With Nonalcoholic Fatty Liver Unknown status NCT03604016 Phase 4 Besifovir dipivoxil;L-carnitine;Tenofovir Alafenamide
10 Effect of Metadoxine on Oxidative Stress in Non-alcoholic Fatty Liver Disease Prediabetic Mexican Patients Unknown status NCT02051842 Phase 4 Metadoxine
11 The Effect of Empagliflozin on NAFLD in Asian Patients With Type 2 Diabetes Unknown status NCT02964715 Phase 4 Empagliflozin
12 Complex Imaging Assessment of Steatosis in Patients Under Treatment With Combination Silimarin, Phyllanthus Niruri and Choline Unknown status NCT02669641 Phase 4
13 Effect of Liraglutide on Fatty Liver Content Evaluated by Proton-spectroscopy (1H-spectroscopy) and Lipoprotein Kinetic, in Patients With Type 2 Diabetes Unknown status NCT02721888 Phase 4 Liraglutide;MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy)
14 Influence of Hepatic Steatosis on the Therapeutic Effect of Entecavir in Chronic Hepatitis B Patients-A Randomized, Double-Blinded, Controlled Trial Unknown status NCT01148576 Phase 4 entecavir;entecavir;essentiale + entecavir;Vitamin E + entecavir
15 Ultrasonographic Modification of Liver Steatosis and Visceral Fat Induced by Treatment With Losartan and Simvastatin in Hypertensive Normocholesterolemic Obese Patients Unknown status NCT00669435 Phase 4 Losartan + Simvastatin;Amlodipine + Simvastatin
16 NAFLD in T2DM: Prevalence in Hispanics and Role of Treatment Completed NCT01002547 Phase 4 pioglitazone-placebo;pioglitazone;pioglitazone-placebo;Vitamin E-placebo
17 Long-term Role of Pioglitazone in Non-Alcoholic Fatty Liver Disease (NAFLD) in Type 2 Diabetes Mellitus (T2DM). Completed NCT00994682 Phase 4 Pioglitazone study drug;Placebo;Pioglitazone Open Label
18 Effects of Exenatide (Byetta®) on Biochemical and Histological Parameters of Liver Function in Patients With Nonalcoholic Steatohepatitis (NASH) Completed NCT01208649 Phase 4 Exenatide
19 Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH) Completed NCT00227110 Phase 4 Pioglitazone;Placebo
20 Clinical Study Evaluating the Efficacy and Safety of Montelukast in the Treatment of Non-Alcoholic Steatohepatitis (NASH) Completed NCT04537780 Phase 4 Montelukast
21 Orlistat (Xenical) in the Treatment of Overweight Patients With Nonalcoholic Steatohepatitis (NASH) Completed NCT00160407 Phase 4 Orlistat (Xenical)
22 The Effects of Purified n-3 Fatty Acids on Serum Fibrosis Markers and Cardiovascular Risk Markers in a Randomized Placebo Controlled Trial in Patients With Non Alcoholic Fatty Liver Disease Completed NCT00760513 Phase 4 OMACOR;Placebo oral capsule
23 Impact of Short-term Fructose-enriched Diet on Serum Metabolome by Normal- and Over-weighed Women. Completed NCT03444233 Phase 4
24 Efficacy of Liraglutide vs. Sitagliptin vs. Insulin Glargine Per Day on Liver Fat When Combined With Metformin in T2DM Subjects With Non-alcoholic Fatty-liver Disease Completed NCT02147925 Phase 4 Liraglutide combined with metformin;Insulin glargine combined with metformin;Sitagliptin combined with metformin
25 PXR-aktivaation Vaikutus Maksan Rasvoittumiseen Completed NCT02329405 Phase 4 Rifampicin;Placebo
26 Use of Vitamin D in Treatment of Non-Alcoholic Fatty Liver Disease Detected by Transient Elastography Completed NCT04038853 Phase 4 1,25-Dihydroxyvitamin D;Placebo
27 Comparison of Efficacy of Liraglutide, Metformin and Gliclazide MR on Hepatic Lipid Content in Patients With Type 2 Diabetes (T2DM) and Non-alcoholic Fatty Liver (NAFLD) Completed NCT03068065 Phase 4 Liraglutide;Metformin;Gliclazide
28 Effects of Ipragliflozin on Excessive Fat in Type 2 Diabetes Patients With Non-alcoholic Fatty Liver Disease Treated With Metformin and Pioglitazone Completed NCT02875821 Phase 4 Ipragliflozin;metformin with pioglitazone
29 The Comparison of Effect Between Salsalate and Placebo in Osteoarthritis With Nonalcoholic Fatty Liver Disease: Investigator Initiated Randomized Placebo-controlled Double-blind, Pilot Study Completed NCT03222206 Phase 4 Salsalate
30 A New Treatment Strategy of Adding Exenatide to Insulin Therapy for Patients With Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD) Completed NCT01006889 Phase 4 Exenatide
31 Exenatide BID Compared With Insulin Glargine to Change Liver Fat Content in Non-alcoholic Fatty-liver Disease Patients With Type 2 Diabetes Completed NCT02303730 Phase 4 Exenatide;insulin glargine
32 A Randomized, Prospective, Open Label, Active Control, Phase IV Study to Evaluate the Effects of Statin Monotherapy or Statin / Ezetimibe Combination Therapy on Hepatic Steatosis in Patients With Hyperlipidemia and Nonalcoholic Fatty Liver Disease Completed NCT03434613 Phase 4 Rosuvastatin;Rosuvastatin/ezetimibe combination
33 Efficacy of Pioglitazone Hydrochloride and Metformin Hydrochloride Tablets on the Patients With Newly Diagnosed Type 2 Diabetes Mellitus Combined With Non-alcoholic Fatty Liver Disease：an Multicenter，Randomized, Double-blind, Parallel- Controlled Study. Completed NCT03796975 Phase 4 Combination of Pioglitazone and Metformin Tablets;Metformin Hydrochloride Tablets
34 Effects of Empagliflozin on Liver Fat Content, Energy Metabolism and Body Composition in Patients With Type 2 Diabetes Completed NCT02637973 Phase 4 Empagliflozin;Placebo
35 A 24 Week, Multicenter, Prospective, Open-labeled, Single-arm, Exploratory Phase 4 Clinical Trial to Evaluate the Safety and Efficacy of Lobeglitazone in Decreasing Intrahepatic Fat Contents in Type 2 Diabetes With NAFLD Completed NCT02285205 Phase 4 Oral administration of Lobeglitazone
36 Effectiveness and Tolerability of Phentermine in the Reduction of Intrahepatic Fat Infiltration, Adipose Tissue and Postoperative Complications in Patients Under Bariatric Surgery Completed NCT03849729 Phase 4 Phentermine
37 The Effect of Vitamin D Supplementation on the Glycemic Control and Non-alcoholic Fatty Liver Disease in Type 2 Diabetes Completed NCT01854463 Phase 4 Vitamin D3;placebo
38 Biochemical and Echosonographic Impacts Using Siliphos-Selenium-Methionine-Alpha Lipoic Acid + Metformin Versus Metformin in Patients With Fatty Liver and Steatohepatitis Completed NCT01650181 Phase 4 Metformin;Metformin
39 A Multi-Centered, Prospective, Randomized, Placebo-Controlled Clinical Trial for the Treatment of Significant Steatosis or NASH With Xenical Followed by Treatment of Hepatitis C (HCV) With PEG-Interferon Alpha-2a/Copegus Completed NCT00207311 Phase 4 Xenical, Pegasys, Copegus
40 Magnetic Resonance Assessment of Victoza Efficacy in the Regression of Cardiovascular Dysfunction In Type 2 Diabetes Mellitus Completed NCT01761318 Phase 4 Liraglutide;Liraglutide - Placebo
41 MRI Substudy; Metabolic Changes Due to Iatrogenic Hypogonadism in Patients With Prostate Cancer: Orchiectomy vs. Triptorelin Completed NCT02102646 Phase 4 Triptorelin
42 Magnetic Resonance Assessment of Victoza Efficacy in the Regression of Cardiovascular Dysfunction In Type 2 Diabetes Mellitus and South Asian Descent Completed NCT02660047 Phase 4 Liraglutide;Liraglutide - Placebo
43 A 24 Week Monocentric Prospective Randomized, Placebo-controlled Trial to Evaluate Efficacy of Combination of Exenatide and Dapagliflozin Compared to Dapagliflozin and Placebo and Its Effects on Hepatic, Myocardial and Pancreatic Fat Distribution in Patients With Uncontrolled Type 2 Diabetes Mellitus. Completed NCT03007329 Phase 4 Exenatide;Exenatide matching Placebo;Dapagliflozin
44 Changes in Liver Steatosis After Switching From Efavirenz to Raltegravir Among HIV/HCV-Coinfected Patients Receiving Two Nucleoside Analogs Plus Efavirenz: The Steral Study Completed NCT01900015 Phase 4 Raltegravir;Efavirenz
45 Effect on Liver Fat, Adipose Tissue and Metabolic Parameters When Switching a Protease Inhibitor or Efavirenz to Once Daily Raltegravir in HIV+ Patients With Body Mass Index Over 25 kg/m2 and With at Least One Metabolic Syndrome Component Completed NCT03374358 Phase 4 Raltegravir
46 To Evaluate the Effect of Nesinaact on Non-alcoholic Steatohepatitis Through MRI and Liver Fibroscan in Patients With Type 2 Diabetes: A Prospective, Open-Label, Single-Arm, Single-Center Clinical Study Recruiting NCT03950505 Phase 4 Nesinaact 25/15 (Alogliptin benzoate 25mg, pioglitazone hydrochloride 15mg) treatment for 24 weeks
47 Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis: a Multicentre, Randomised, Placebo-controlled Trial Recruiting NCT03198572 Phase 4 Placebo;Berberine
48 Comparison of The Effects of Thiazolidinediones(TZD), Sodium- Glucose Cotransporter 2 Inhibitors(SGLT2i) Alone and TZD / SGLT2i Combination Therapy on Non-alcoholic Fatty Liver Disease in Type 2 Diabetic Patients With Fatty Liver Recruiting NCT03646292 Phase 4 Pioglitazone;Empagliflozin;Combination of pioglitazone and empagliflozin
49 S.P.PRO LIVER POWDER is Used to Improve Liver and Metabolic Indexes in People With Non-alcoholic Fatty Liver Disease Recruiting NCT04718051 Phase 4 Shen Pu Yang Gan Wan;Placebo
50 The Effect of Consecutive Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease (NAFLD) - a Randomized-controlled Trial - Recruiting NCT04465032 Phase 4

Search NIH Clinical Center for Fatty Liver Disease

Cochrane evidence based reviews: fatty liver

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Genetic Tests for Fatty Liver Disease

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Anatomical Context for Fatty Liver Disease

About this section

MalaCards organs/tissues related to Fatty Liver Disease:

40
Liver, Kidney, Endothelial, Ovary, Skeletal Muscle, Adipocyte, Pancreas
Sources

Publications for Fatty Liver Disease

About this section

Articles related to Fatty Liver Disease:

(show top 50) (show all 30217)
# Title Authors PMID Year
1
Complementary and alternative therapies for non-alcoholic fatty liver disease: A Bayesian network meta-analysis protocol. 42 61
33530243 2021
2
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Sources

Variations for Fatty Liver Disease

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ClinVar genetic disease variations for Fatty Liver Disease:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 PRMT7 NM_019023.5(PRMT7):c.1713C>A (p.Cys571Ter) SNV Pathogenic 523434 rs1251713297 16:68389688-68389688 16:68355785-68355785
2 PRMT7 NM_019023.5(PRMT7):c.322G>T (p.Glu108Ter) SNV Pathogenic 523435 rs1014959895 16:68363008-68363008 16:68329105-68329105
3 OPA1 NM_001354663.2(OPA1):c.-260_-243del Deletion Uncertain significance 214916 rs863224140 3:193332587-193332604 3:193614798-193614815
4 MT-TL1 NC_012920.1:m.3275C>T SNV Uncertain significance 370045 rs1057516057 MT:3275-3275 MT:3275-3275
Sources

Expression for Fatty Liver Disease

About this section
Search GEO for disease gene expression data for Fatty Liver Disease.
Sources

Pathways for Fatty Liver Disease

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Pathways related to Fatty Liver Disease according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Metabolism 65
Show member pathways
 14 SREBF1 PPARA PNPLA3 MTTP MLXIPL INS
2
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 65
Show member pathways
 13 TNF SREBF1 PPARA MLXIPL LEPR LEP
3
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 65
Show member pathways
 12.8 TNF SREBF1 PPARA LEP FABP1 ADIPOQ
4
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 64
Show member pathways
 12.68 TNF LEP INSR INS IL6 ADIPOQ
5
Glucose / Energy Metabolism 4
12.42 SREBF1 INSR INS FABP1 ADIPOQ
6
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.37 SREBF1 LEPR LEP INSR INS ADIPOR2
7
Integration of energy metabolism 65
Show member pathways
 12.24 MLXIPL INS ADIPOR2 ADIPOQ
8
Folate Metabolism 1
Show member pathways
 12.21 TNF INSR INS IL6 GGT1
10
Longevity regulating pathway 36
Show member pathways
 12.04 INSR INS ADIPOR2 ADIPOQ
11
Type II diabetes mellitus 36 1
Show member pathways
 11.79 TNF INSR INS ADIPOQ
12
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.77 LEP INS IL6 ADIPOQ
13
PPAR signaling pathway 36
11.64 PPARA FABP1 ADIPOQ
14
Adipocytokine signaling pathway 36
11.64 TNF PPARA LEPR LEP ADIPOR2 ADIPOQ
15
Insulin resistance 36
Show member pathways
 11.54 TNF SREBF1 PPARA MLXIPL INSR INS
16
Signaling events mediated by PTP1B 1
11.43 LEPR LEP INSR INS
17
Adipogenesis 1
11.35 TNF SREBF1 PPARA PNPLA3 LEP INS
18
Transcription factor regulation in adipogenesis 1
11 TNF LEP INSR IL6 ADIPOQ
19
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.93 LEPR LEP INS
Sources

GO Terms for Fatty Liver Disease

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Biological processes related to Fatty Liver Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.98 SREBF1 PNPLA3 MTTP LEP GGT1 CYP2E1
2 fatty acid metabolic process GO:0006631 9.95 PPARA GGT1 CYP2E1 ADIPOR2
3 positive regulation of protein kinase B signaling GO:0051897 9.94 TNF LEP INSR INS
4 insulin receptor signaling pathway GO:0008286 9.87 SREBF1 INSR INS
5 response to nutrient GO:0007584 9.87 LEP ADIPOR2 ADIPOQ
6 response to nutrient levels GO:0031667 9.87 LEP ADIPOR2 ADIPOQ
7 positive regulation of MAPK cascade GO:0043410 9.87 LEP INSR INS IL6
8 response to bacterium GO:0009617 9.86 SLC17A5 CYP2E1 ADIPOR2 ADIPOQ
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 TNF LEP IL6
10 response to glucocorticoid GO:0051384 9.85 TNF IL6 ADIPOQ
11 positive regulation of cold-induced thermogenesis GO:0120162 9.84 LEPR LEP ADIPOR2 ADIPOQ
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.83 TNF LEP INSR INS
13 positive regulation of interleukin-8 production GO:0032757 9.82 TNF IL6 ADIPOQ
14 positive regulation of cytokine production GO:0001819 9.81 TNF LEP INS
15 circadian rhythm GO:0007623 9.81 SREBF1 MTTP LEP ADIPOQ
16 negative regulation of fat cell differentiation GO:0045599 9.79 TNF IL6 ADIPOQ
17 response to activity GO:0014823 9.79 LEP IL6 ADIPOQ
18 regulation of insulin secretion GO:0050796 9.76 TNF SREBF1 LEP IL6
19 positive regulation of JAK-STAT cascade GO:0046427 9.75 TNF LEP IL6
20 positive regulation of protein phosphorylation GO:0001934 9.73 TNF LEPR LEP INSR ADIPOR2 ADIPOQ
21 positive regulation of glycolytic process GO:0045821 9.72 MLXIPL INSR INS
22 glucose metabolic process GO:0006006 9.71 TNF LEP INS ADIPOQ
23 positive regulation of neuroinflammatory response GO:0150078 9.7 TNF IL6
24 neuron projection maintenance GO:1990535 9.69 INSR INS
25 regulation of fatty acid biosynthetic process GO:0042304 9.69 ADIPOR2 ADIPOQ
26 leptin-mediated signaling pathway GO:0033210 9.68 LEPR LEP
27 negative regulation of appetite GO:0032099 9.68 PPARA LEP
28 positive regulation of fatty acid beta-oxidation GO:0032000 9.68 PPARA FABP1
29 sexual reproduction GO:0019953 9.68 LEPR LEP
30 regulation of fatty acid metabolic process GO:0019217 9.67 SREBF1 PPARA
31 positive regulation of lipid biosynthetic process GO:0046889 9.67 PPARA MLXIPL INS
32 regulation of lipid storage GO:0010883 9.66 SREBF1 PPARA
33 positive regulation of respiratory burst GO:0060267 9.66 INSR INS
34 vascular endothelial growth factor production GO:0010573 9.65 TNF IL6
35 response to sucrose GO:0009744 9.65 PNPLA3 ADIPOQ
36 negative regulation of gluconeogenesis GO:0045721 9.65 LEPR INS ADIPOQ
37 bone growth GO:0098868 9.63 LEPR LEP
38 response to ethanol GO:0045471 9.63 SREBF1 PPARA LEP CYP2E1 ADIPOR2 ADIPOQ
39 regulation of bone remodeling GO:0046850 9.62 LEPR LEP
40 positive regulation of glucose import GO:0046326 9.62 INSR INS ADIPOR2 ADIPOQ
41 positive regulation of developmental growth GO:0048639 9.61 LEP INSR
42 positive regulation of fatty acid metabolic process GO:0045923 9.6 PPARA ADIPOQ
43 positive regulation of protein complex disassembly GO:0043243 9.59 TNF INSR
44 lipid localization GO:0010876 9.58 SREBF1 PPARA
45 negative regulation of lipid storage GO:0010888 9.54 TNF LEP IL6
46 cellular response to insulin stimulus GO:0032869 9.43 SREBF1 PNPLA3 LEP INSR GPT ADIPOQ
47 glucose homeostasis GO:0042593 9.23 MLXIPL LEPR LEP INSR INS IL6
Sources

Sources for Fatty Liver Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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