MCID: FBR031
MIFTS: 52

Febrile Seizures

Categories: Genetic diseases, Neuronal diseases, Oral diseases, Rare diseases
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Aliases & Classifications for Febrile Seizures

Summaries for Febrile Seizures

NINDS: 52 Febrile seizures are convulsions or seizures in infants or small children that are brought on by a fever or febrile illness. The seizures may come before the fever. Most often during a febrile seizure, a child loses consciousness and shakes uncontrollably. Less commonly, a child becomes rigid or has twitches in only a portion of the body. Most febrile seizures last a minute or two; some can be as brief as a few seconds, while others may last for more than 15 minutes. Approximately one in every 25 children will have at least one febrile seizure. Febrile seizures usually occur in children between the ages of 6 months and 5 years, with the risk peaking in the second year of life. The older a child is when the first febrile seizure occurs, the less likely that child is to have more febrile seizures as they will spend less time in the age group at risk.  A few factors appear to boost a child's risk of having recurrent febrile seizures, including a family history of febrile seizures in a first- or second-degree relative, a young age (less than 18 months) at the first febrile seizure, having a lower peak temperature during the illness when the febrile seizure occurs, and the febrile seizure occurring within an hour of recognized fever.

MalaCards based summary: Febrile Seizures, also known as febrile seizure, is related to generalized epilepsy with febrile seizures plus, type 1 and febrile seizures, familial, 8, and has symptoms including fever, seizures and other convulsions. An important gene associated with Febrile Seizures is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Nervous system development and Cardiac conduction. The drugs Acetaminophen and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related phenotypes are nervous system and normal

Wikipedia: 75 A febrile seizure, also known as a fever fit or febrile convulsion, is a seizure associated with an... more...

Related Diseases for Febrile Seizures

Diseases in the Febrile Seizures family:

Febrile Seizures, Familial, 1 Febrile Seizures, Familial, 4
Febrile Seizures, Familial, 8 Febrile Seizures, Familial, 6
Febrile Seizures, Familial, 5 Febrile Seizures, Familial, 7
Febrile Seizures, Familial, 9 Febrile Seizures, Familial, 10
Febrile Seizures, Familial, 11 Familial Febrile Seizures

Diseases related to Febrile Seizures via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 390)
# Related Disease Score Top Affiliating Genes
1 generalized epilepsy with febrile seizures plus, type 1 33.0 SCN1B SCN1A GABRG2
2 febrile seizures, familial, 8 32.8 SCN1B SCN1A GABRG2 GABRD ADGRV1
3 febrile seizures, familial, 11 32.6 SCN1A GABRG2 GABRD CPA6 ADGRV1
4 generalized epilepsy with febrile seizures plus, type 4 32.6 SCN1B GABRG2 GABRD ADGRV1
5 generalized epilepsy with febrile seizures plus, type 6 32.6 SCN1B GABRG2 GABRD ADGRV1
6 generalized epilepsy with febrile seizures plus, type 7 32.5 SCN9A SCN1B SCN1A GABRG2 GABRD ADGRV1
7 febrile seizures, familial, 4 32.5 SCN1B SCN1A GABRG2 GABRD ADGRV1
8 febrile seizures, familial, 9 32.3 SCN1B GABRG2 GABRD ADGRV1
9 febrile seizures, familial, 7 32.3 SCN1B GABRG2 GABRD ADGRV1
10 generalized epilepsy with febrile seizures plus, type 2 32.1 SCN9A SCN2A SCN1B SCN1A LOC102724058 GABRG2
11 generalized epilepsy with febrile seizures plus 31.7 SCN9A SCN8A SCN2A SCN1B SCN1A HCN1
12 childhood absence epilepsy 31.3 SCN8A SCN2A SCN1B SCN1A GABRG2 GABRD
13 familial febrile seizures 30.9 SCN9A SCN8A SCN2A SCN1B SCN1A IMPA2
14 dravet syndrome 30.8 SCN9A SCN8A SCN2A SCN1B SCN1A LOC102724058
15 juvenile absence epilepsy 30.7 SCN1A GABRG2 GABRD
16 focal epilepsy 30.5 SCN8A SCN2A SCN1A GABRG2 GABRD
17 scn1a seizure disorders 30.4 SCN1A LOC102724058
18 early myoclonic encephalopathy 30.3 SCN8A SCN2A SCN1B SCN1A GABRG2 GABRD
19 epilepsy, familial temporal lobe, 5 30.1 SCN1A CPA6
20 unverricht-lundborg syndrome 30.0 SCN1B SCN1A
21 developmental and epileptic encephalopathy 7 30.0 SCN2A SCN1A
22 brugada syndrome 29.9 SCN9A SCN8A SCN2A SCN1B SCN1A
23 photosensitive epilepsy 29.9 SCN2A SCN1A GABRG2 GABRD
24 migraine with or without aura 1 29.9 SCN9A SCN8A SCN2A SCN1A
25 epilepsy, familial temporal lobe, 1 29.9 SCN1B SCN1A GABRG2 ADGRV1
26 ohtahara syndrome 29.8 SCN8A SCN2A SCN1A LOC102724058 HCN1
27 autism spectrum disorder 29.8 SCN2A SCN1A HCN1 GABRG2 GABRD
28 early onset absence epilepsy 29.8 SCN2A SCN1B SCN1A GABRG2
29 epilepsy with generalized tonic-clonic seizures 29.7 SCN8A SCN2A SCN1B SCN1A GABRG2 GABRD
30 non-specific early-onset epileptic encephalopathy 29.6 SCN8A HCN1 GABRG2
31 benign neonatal seizures 29.6 SCN8A SCN2A SCN1B SCN1A
32 autosomal dominant nocturnal frontal lobe epilepsy 29.6 SCN8A SCN2A SCN1B SCN1A GABRG2 GABRD
33 benign familial infantile epilepsy 29.6 SCN9A SCN8A SCN2A SCN1B SCN1A GABRG2
34 epilepsy 29.6 SCN9A SCN8A SCN2A SCN1B SCN1A HCN1
35 epilepsy, idiopathic generalized 29.6 SCN9A SCN8A SCN2A SCN1B SCN1A HCN1
36 familial hemiplegic migraine 29.6 SCN9A SCN8A SCN2A SCN1A
37 progressive myoclonus epilepsy 29.6 SCN8A SCN2A SCN1B SCN1A GABRG2
38 west syndrome 29.5 SCN9A SCN8A SCN2A SCN1B SCN1A GABRG2
39 benign familial neonatal epilepsy 29.5 SCN8A SCN2A SCN1B SCN1A GABRG2
40 epilepsy, myoclonic juvenile 29.5 SCN8A SCN2A SCN1B SCN1A GABRG2 GABRD
41 developmental and epileptic encephalopathy 29.1 SCN9A SCN8A SCN2A SCN1B SCN1A LOC102724058
42 nervous system disease 29.0 SCN9A SCN8A SCN2A SCN1A GRIN1 CHAT
43 early infantile epileptic encephalopathy 28.7 SCN9A SCN8A SCN2A SCN1B SCN1A LOC102724058
44 autism 28.4 SCN9A SCN8A SCN2A SCN1A LOC102724058 HCN1
45 benign epilepsy with centrotemporal spikes 27.9 SCN9A SCN8A SCN2A SCN1B SCN1A LOC102724058
46 generalized epilepsy with febrile seizures plus, type 9 11.8
47 epilepsy, idiopathic generalized 17 11.7
48 generalized epilepsy with febrile seizures plus, type 10 11.7
49 generalized epilepsy with febrile seizures plus, type 8 11.7
50 epilepsy, idiopathic generalized 10 11.7

Graphical network of the top 20 diseases related to Febrile Seizures:



Diseases related to Febrile Seizures

Symptoms & Phenotypes for Febrile Seizures

UMLS symptoms related to Febrile Seizures:


fever; seizures; other convulsions; symptomatic seizures

MGI Mouse Phenotypes related to Febrile Seizures:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.1 ADGRV1 CHAT GABRD GABRG2 GRIN1 HCN1
2 normal MP:0002873 10.02 CHAT GABRG2 GRIN1 HCN1 IMPA2 MFSD2A
3 behavior/neurological MP:0005386 10 ADGRV1 CHAT GABRD GABRG2 GRIN1 HCN1
4 mortality/aging MP:0010768 9.36 ADGRV1 CHAT GABRD GABRG2 GRIN1 MFSD2A
5 taste/olfaction MP:0005394 9.13 GRIN1 HCN1 SCN9A

Drugs & Therapeutics for Febrile Seizures

Drugs for Febrile Seizures (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
4
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
5 Immunologic Factors Phase 4
6 Vaccines Phase 4
7 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
8 Antirheumatic Agents Phase 4
9 Antipyretics Phase 4
10 Cyclooxygenase Inhibitors Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Analgesics, Non-Narcotic Phase 4
14 Analgesics Phase 4
15 Antioxidants Phase 4
16 Protective Agents Phase 4
17
Diazepam Approved, Illicit, Investigational, Vet_approved 439-14-5 3016
18
Clonazepam Approved, Illicit 1622-61-3 2802
19
Arginine Approved, Investigational, Nutraceutical 74-79-3 6322
20 Neurotransmitter Agents
21 Anti-Anxiety Agents
22 Psychotropic Drugs
23 Antiemetics
24 Anesthetics, Intravenous
25 Anticonvulsants
26 Anesthetics, General
27 Anesthetics
28 Hypnotics and Sedatives
29 GABA Modulators
30 Gastrointestinal Agents
31 Arginine Vasopressin
32 Vasopressins
33 Vasoconstrictor Agents
34 Hemostatics
35 Coagulants

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Open-label Clinical Trial to Assess Fever Following Simultaneous Versus Sequential Administration of PCV13, DTaP Vaccine and IIV in Young Children Completed NCT03165981 Phase 4
2 Antipyretics for Preventing Recurrences of Febrile Seizures Completed NCT00568217 Phase 4 Diclofenac, Paracetamol, Ibuprofen
3 Comparison Between Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures: Randomized Clinical Trial Completed NCT03631901 Phase 4 oral melatonin;oral diazepam
4 Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures Terminated NCT01370044 Phase 2, Phase 3 Carbogen;Placebo
5 Investigation of the Respiratory Physiology of Children With and Without Febrile Seizures During Febrile Illness. Unknown status NCT01906619
6 Viral Respiratory and Gastrointestinal Infections in Children Under 6 Years of Age - the Clinical Relevance of Newly Discovered Viruses Unknown status NCT00987519
7 Nervous System Infections Among Patients With Febrile Seizure : Retrospective Cohort Review of Consecutive Patients Admitted in 7 Pediatric Emergency Departments in Ile-de-France Between 2007 and 2011 Completed NCT01694524
8 Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures Completed NCT04368936
9 Serum Levels of Adipocytokines in Children With Febrile Seizures: A Cross-Sectional Study at Sohag University Hospital Completed NCT04967066
10 Anthropogenetic Variability in the Group of Individuals With Febrile Seizures - Population Genetic Study Completed NCT03481764
11 Pharmacoepidemiological Methodology to Evaluate the Vaccination Risk in Young Infants Completed NCT01931813
12 The Relevance of Performing Lumbar Puncture in Infants Aged 3 to 12 Months With First Episode of Febrile Convulsion Completed NCT01443611
13 Prospective Study on Copeptin in Childhood Epilepsy Completed NCT01884766
14 Value of Copeptin Assay in Children With Febrile Seizures at Sohag University Hospital Recruiting NCT05215366
15 The Efficacy of A Single Dose Clonazepam Compared With the Intermittent Diazepam to Prevent Recurrent Febrile Seizures in Queen Sirikit National Institute of Child Health Recruiting NCT04364321 Clonazepam 0.5 MG;Diazepam Tablets
16 Value of Von Willebrand Factor and Copeptin Assay in Children With Febrile Seizures at Sohag University Hospital Not yet recruiting NCT05008458

Search NIH Clinical Center for Febrile Seizures

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Phenobarbital
Phenobarbital Sodium

Genetic Tests for Febrile Seizures

Genetic tests related to Febrile Seizures:

# Genetic test Affiliating Genes
1 Febrile Seizure (within the Age Range of 3 Months to 6 Years) 28

Anatomical Context for Febrile Seizures

Organs/tissues related to Febrile Seizures:

MalaCards : Temporal Lobe, Brain, Cortex, Amygdala, Skeletal Muscle, Neutrophil, Eye

Publications for Febrile Seizures

Articles related to Febrile Seizures:

(show top 50) (show all 4558)
# Title Authors PMID Year
1
Mechanisms for variable expressivity of inherited SCN1A mutations causing Dravet syndrome. 53 62
20522430 2010
2
Mutations in GABAA receptor subunits associated with genetic epilepsies. 53 62
20308251 2010
3
Generalized epilepsy with febrile seizures plus: novel SCN1A mutation. 53 62
20117752 2010
4
SCN1A mutation screening in adult patients with Lennox-Gastaut syndrome features. 53 62
19782004 2009
5
Advances on the genetics of mendelian idiopathic epilepsies. 53 62
19853223 2009
6
Parental SCN1A mutation mosaicism in familial Dravet syndrome. 53 62
19673951 2009
7
Severe epilepsy syndromes of early childhood: the link between genetics and pathophysiology with a focus on SCN1A mutations. 53 62
19666879 2009
8
[Clinical analysis and screening for SCN1A gene mutation in two pedigrees of generalized epilepsies with febrile seizures plus]. 53 62
19951487 2009
9
Clinical spectrum of SCN1A mutations. 53 62
19469841 2009
10
Dravet syndrome or genetic (generalized) epilepsy with febrile seizures plus? 53 62
19203856 2009
11
Does a SCN1A gene mutation confer earlier age of onset of febrile seizures in GEFS+? 53 62
19292758 2009
12
A novel inherited mutation in the voltage sensor region of SCN1A is associated with Panayiotopoulos syndrome in siblings and generalized epilepsy with febrile seizures plus. 53 62
19339291 2009
13
A splice site variant in the sodium channel gene SCN1A confers risk of febrile seizures. 53 62
19289736 2009
14
The GABRG2 mutation, Q351X, associated with generalized epilepsy with febrile seizures plus, has both loss of function and dominant-negative suppression. 53 62
19261880 2009
15
Febrile seizures: interleukin 1beta and interleukin-1 receptor antagonist polymorphisms. 53 62
19135625 2009
16
Novel de novo splice-site mutation of SCN1A in a patient with partial epilepsy with febrile seizures plus. 53 62
18632234 2009
17
[Analysis of the GABRG2 gene mutation in a Chinese family with generalized epilepsy with febrile seizures plus]. 53 62
19065515 2008
18
Genetic screening of Scandinavian families with febrile seizures and epilepsy or GEFS+. 53 62
17927801 2008
19
[Epilepsy in Israel--2008]. 53 62
18357670 2008
20
Genetic etiology of new forms of familial epilepsy. 53 62
17981785 2008
21
SCN1A, SCN1B, and GABRG2 gene mutation analysis in Chinese families with generalized epilepsy with febrile seizures plus. 53 62
18566737 2008
22
GEFS+ is not related to the most common mutations of SCN1B, SCN1A and GABRG2 in two Tunisian families. 53 62
18175077 2007
23
Neuropeptide Y gene polymorphism and plasma neuropeptide Y level in febrile seizure patients in Taiwan. 53 62
18055304 2007
24
Idiopathic epilepsies with seizures precipitated by fever and SCN1A abnormalities. 53 62
17561957 2007
25
GEFS+ where focal seizures evolve from generalized spike wave: video-EEG study of two children. 53 62
17884755 2007
26
Association analysis of gamma2 subunit of gamma-aminobutyric acid (GABA) type A receptor and voltage-gated sodium channel type II alpha-polypeptide gene mutation in southern Chinese children with febrile seizures. 53 62
17641256 2007
27
Patients with a sodium channel alpha 1 gene mutation show wide phenotypic variation. 53 62
17507202 2007
28
Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures. 53 62
17340635 2007
29
Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. 53 62
17388992 2007
30
Neuropeptide Y: potential role in recurrent developmental seizures. 53 62
17196709 2007
31
Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. 53 62
17020904 2007
32
Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. 53 62
17068342 2007
33
Role of genetics in the diagnosis and treatment of epilepsy. 53 62
17181426 2006
34
Epilepsy with a de novo missense mutation in the sodium channel a1 subunit: a case report. 53 62
17129991 2006
35
Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy-associated SCN1A mutation. 53 62
17065438 2006
36
Familial occurrence of febrile seizures and epilepsy in severe myoclonic epilepsy of infancy (SMEI) patients with SCN1A mutations. 53 62
17054684 2006
37
A novel GABRG2 mutation associated with febrile seizures. 53 62
16924025 2006
38
Phenotypes and genotypes in epilepsy with febrile seizures plus. 53 62
16884893 2006
39
Molecular genetics of febrile seizures. 53 62
16887333 2006
40
Na channel gene mutations in epilepsy--the functional consequences. 53 62
16806834 2006
41
Increased IL-1beta production from dsRNA-stimulated leukocytes in febrile seizures. 53 62
16876005 2006
42
Mutations in GABRA1, GABRA5, GABRG2 and GABRD receptor genes are not a major factor in the pathogenesis of familial focal epilepsy preceded by febrile seizures. 53 62
16256272 2006
43
Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic-clonic seizures. 53 62
16210358 2005
44
A missense mutation in SCN1A in brothers with severe myoclonic epilepsy in infancy (SMEI) inherited from a father with febrile seizures. 53 62
16122630 2005
45
Seizures of idiopathic generalized epilepsies. 53 62
16302874 2005
46
Endogenous neuropeptide Y prevents recurrence of experimental febrile seizures by increasing seizure threshold. 53 62
15800380 2005
47
Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18. 53 62
15557493 2004
48
Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy. 53 62
15263074 2004
49
Febrile convulsions and genetic susceptibility: role of the neuronal nicotinic acetylcholine receptor alpha 4 subunit. 53 62
15101840 2004
50
Clinical correlations of mutations in the SCN1A gene: from febrile seizures to severe myoclonic epilepsy in infancy. 53 62
15087100 2004

Variations for Febrile Seizures

ClinVar genetic disease variations for Febrile Seizures:

5 (show all 17)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SCN1A NM_001165963.4(SCN1A):c.327C>G (p.Tyr109Ter) SNV Pathogenic
437911 rs1553553485 GRCh37: 2:166915136-166915136
GRCh38: 2:166058626-166058626
2 HCN1 NM_021072.4(HCN1):c.737A>C (p.Glu246Ala) SNV Pathogenic
1341556 GRCh37: 5:45645399-45645399
GRCh38: 5:45645297-45645297
3 CHAT NM_020549.5(CHAT):c.2081C>G (p.Ser694Cys) SNV Pathogenic
523529 rs201439531 GRCh37: 10:50872926-50872926
GRCh38: 10:49664880-49664880
4 CHAT NM_020549.5(CHAT):c.1061C>T (p.Thr354Met) SNV Pathogenic
523528 rs769234940 GRCh37: 10:50835781-50835781
GRCh38: 10:49627735-49627735
5 SCN1A, LOC102724058 NM_001165963.4(SCN1A):c.3327dup (p.Ser1110fs) DUP Pathogenic
599005 rs1559193213 GRCh37: 2:166892659-166892660
GRCh38: 2:166036149-166036150
6 MFSD2A NM_032793.5(MFSD2A):c.229-25_229-23del DEL Pathogenic
684729 rs1570238098 GRCh37: 1:40424346-40424348
GRCh38: 1:39958674-39958676
7 SCN2A NM_001040142.2(SCN2A):c.3043G>A (p.Asp1015Asn) SNV Pathogenic
331730 rs747451714 GRCh37: 2:166210825-166210825
GRCh38: 2:165354315-165354315
8 GRIN1 NM_007327.4(GRIN1):c.2531G>T (p.Arg844Leu) SNV Likely Pathogenic
598966 rs1564365418 GRCh37: 9:140058298-140058298
GRCh38: 9:137163846-137163846
9 SCN8A NM_001330260.2(SCN8A):c.4235T>C (p.Phe1412Ser) SNV Likely Pathogenic
523505 rs1555228665 GRCh37: 12:52182486-52182486
GRCh38: 12:51788702-51788702
10 AMER1 NM_152424.4(AMER1):c.1911_1912del (p.Glu637fs) MICROSAT Uncertain Significance
523561 rs1555933313 GRCh37: X:63411255-63411256
GRCh38: X:64191375-64191376
11 OCA2 NM_000275.3(OCA2):c.2020C>G (p.Leu674Val) SNV Uncertain Significance
194918 rs371412500 GRCh37: 15:28171332-28171332
GRCh38: 15:27926186-27926186
12 SLC30A3 NM_003459.5(SLC30A3):c.1154C>G (p.Pro385Arg) SNV Uncertain Significance
1342466 GRCh37: 2:27478193-27478193
GRCh38: 2:27255325-27255325
13 SCN2A NM_001040143.2(SCN2A):c.4447-1C>A SNV Uncertain Significance
1676604 GRCh37:
GRCh38:
14 ARFGEF3 NM_020340.5(ARFGEF3):c.1960C>T (p.Arg654Ter) SNV Uncertain Significance
1705269 GRCh37: 6:138584580-138584580
GRCh38: 6:138263443-138263443
15 TNFRSF1A NM_001065.4(TNFRSF1A):c.434A>G (p.Asn145Ser) SNV Uncertain Significance
97703 rs104895288 GRCh37: 12:6442571-6442571
GRCh38: 12:6333405-6333405
16 NF1 NM_001042492.3(NF1):c.1987G>A (p.Gly663Arg) SNV Uncertain Significance
184278 rs140653372 GRCh37: 17:29552254-29552254
GRCh38: 17:31225236-31225236
17 HCN2 NM_001194.4(HCN2):c.1348G>T (p.Val450Leu) SNV Not Provided
1339851 GRCh37: 19:608093-608093
GRCh38: 19:608093-608093

Expression for Febrile Seizures

Search GEO for disease gene expression data for Febrile Seizures.

Pathways for Febrile Seizures

Pathways related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.43 SCN9A SCN8A SCN2A SCN1B SCN1A GRIN1
2
Show member pathways
12.59 SCN9A SCN8A SCN2A SCN1B SCN1A
3
Show member pathways
12.42 SCN9A SCN8A SCN2A SCN1B SCN1A
4
Show member pathways
12.39 SCN9A SCN8A SCN2A SCN1B SCN1A GRIN1
5 12.27 SCN9A SCN8A SCN2A SCN1B SCN1A GRIN1
6
Show member pathways
12.04 SCN1A SCN1B SCN2A SCN8A SCN9A
7
Show member pathways
11.8 SCN9A SCN2A SCN1B
8
Show member pathways
11.8 HCN1 GRIN1 GABRG2 GABRD
9 11.14 SCN8A SCN2A SCN1A GABRD
10 10.98 MFSD2A CHAT
11 10.89 SCN9A SCN8A SCN2A SCN1B SCN1A
12 10.87 SCN1B SCN1A
13 10.71 GABRG2 GABRD
14 10.51 SCN9A SCN8A SCN2A SCN1B SCN1A

GO Terms for Febrile Seizures

Cellular components related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.51 ADGRV1 GABRD GABRG2 GRIN1 HCN1 MFSD2A
2 membrane GO:0016021 10.51 ADGRV1 GABRD GABRG2 GRIN1 HCN1 MFSD2A
3 plasma membrane GO:0005887 10.4 GABRD GABRG2 GRIN1 HCN1 MFSD2A SCN1B
4 plasma membrane GO:0005886 10.4 GABRD GABRG2 GRIN1 HCN1 MFSD2A SCN1B
5 neuron projection GO:0043005 10.13 SCN9A GRIN1 GABRG2 GABRD CHAT
6 postsynaptic membrane GO:0045211 9.93 HCN1 GRIN1 GABRG2 GABRD
7 intercalated disc GO:0014704 9.91 SCN1A SCN1B SCN2A
8 T-tubule GO:0030315 9.88 SCN2A SCN1B SCN1A
9 axon GO:0030424 9.83 GABRD GABRG2 HCN1 SCN1A SCN1B SCN2A
10 node of Ranvier GO:0033268 9.76 SCN8A SCN2A SCN1B SCN1A
11 sodium channel complex GO:0034706 9.56 SCN2A SCN1B SCN1A
12 voltage-gated sodium channel complex GO:0001518 9.32 SCN9A SCN8A SCN2A SCN1B SCN1A

Biological processes related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of membrane potential GO:0042391 10.11 SCN1A HCN1 GRIN1 GABRG2 GABRD
2 regulation of monoatomic ion transmembrane transport GO:0034765 10.1 HCN1 SCN1A SCN1B SCN2A SCN8A SCN9A
3 sodium ion transmembrane transport GO:0035725 10.1 SCN9A SCN8A SCN2A SCN1B SCN1A HCN1
4 excitatory postsynaptic potential GO:0060079 10.08 SEZ6 GRIN1 GABRG2 GABRD
5 transmembrane transport GO:0055085 10.04 HCN1 MFSD2A SCN1A SCN2A SCN8A SCN9A
6 nervous system process GO:0050877 10 GABRG2 GABRD ADGRV1
7 membrane depolarization during action potential GO:0086010 9.97 SCN9A SCN8A SCN2A SCN1A
8 sodium ion transport GO:0006814 9.96 HCN1 SCN1A SCN1B SCN2A SCN8A SCN9A
9 monoatomic cation transmembrane transport GO:0098655 9.91 SCN9A SCN8A SCN2A SCN1A GRIN1
10 cardiac muscle cell action potential involved in contraction GO:0086002 9.86 SCN1B SCN1A
11 regulation of dendrite development GO:0050773 9.85 SEZ6 MFSD2A
12 neuronal action potential propagation GO:0019227 9.84 SCN1B SCN1A
13 regulation of postsynaptic membrane potential GO:0060078 9.81 HCN1 GABRG2 GABRD
14 neuronal action potential GO:0019228 9.81 SCN9A SCN8A SCN2A SCN1A HCN1
15 monoatomic ion transport GO:0006811 9.61 SCN9A SCN8A SCN2A SCN1B SCN1A HCN1
16 monoatomic ion transmembrane transport GO:0034220 9.32 SCN9A SCN8A SCN2A SCN1B SCN1A GRIN1

Molecular functions related to Febrile Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated monoatomic ion channel activity GO:0005244 9.96 SCN9A SCN8A SCN2A SCN1B SCN1A HCN1
2 voltage-gated sodium channel activity GO:0005248 9.93 SCN9A SCN8A SCN2A SCN1B SCN1A HCN1
3 monoatomic cation channel activity GO:0005261 9.62 SCN9A SCN8A SCN2A SCN1A
4 sodium channel activity GO:0005272 9.43 SCN9A SCN8A SCN2A SCN1B SCN1A HCN1
5 monoatomic ion channel activity GO:0005216 9.23 SCN9A SCN8A SCN2A SCN1A HCN1 GRIN1

Sources for Febrile Seizures

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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