MCID: FBR031
MIFTS: 51

Febrile Seizures

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Febrile Seizures

MalaCards integrated aliases for Febrile Seizures:

Name: Febrile Seizures 53 36 29 6
Febrile Convulsions 71 32
Seizures Febrile 54

Classifications:



External Ids:

KEGG 36 H00783
ICD10 32 R56.0
UMLS 71 C0009952

Summaries for Febrile Seizures

NINDS : 53 Febrile seizures are convulsions or seizures in infants or small children that are brought on by a fever or febrile illness. The seizures may come before the fever. Most often during a febrile seizure, a child loses consciousness and shakes uncontrollably. Less commonly, a child becomes rigid or has twitches in only a portion of the body. Most febrile seizures last a minute or two; some can be as brief as a few seconds, while others may last for more than 15 minutes. Approximately one in every 25 children will have at least one febrile seizure. Febrile seizures usually occur in children between the ages of 6 months and 5 years, with the risk peaking in the second year of life. The older a child is when the first febrile seizure occurs, the less likely that child is to have more febrile seizures as they will spend less time in the age group at risk.  A few factors appear to boost a child's risk of having recurrent febrile seizures, including a family history of febrile seizures in a first- or second-degree relative, a young age (less than 18 months) at the first febrile seizure, having a lower peak temperature during the illness when the febrile seizure occurs, and the febrile seizure occurring within an hour of recognized fever.

MalaCards based summary : Febrile Seizures, also known as febrile convulsions, is related to generalized epilepsy with febrile seizures plus, type 7 and generalized epilepsy with febrile seizures plus, type 1, and has symptoms including seizures, fever and other convulsions. An important gene associated with Febrile Seizures is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Dopaminergic synapse and Neuroactive ligand-receptor interaction. The drugs Diazepam and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and testes, and related phenotypes are behavior/neurological and nervous system

KEGG : 36 Febrile seizures (FS), or febrile convulsions (FEB), are acute symptomatic seizures that occur in response to fever and represent the most common form of childhood seizures. Generalized epilepsy with febrile seizures plus (GEFS+) is a familial epilepsy syndrome with a spectrum of phenotypes including FS. Severe epilepsy phenotypes such as Dravet syndrome (SMEI) have also been described within GEFS+ families. A significant genetic component exists for susceptibility to FS and GEFS+. Extensive genetic studies have shown that at least ten loci are responsible for FS. Furthermore, mutations in the voltage-gated sodium channel subunit genes (SCN1A, SCN2A and SCN1B) and the GABA(A) receptor subunit genes (GABRG2 and GABRD) have been identified in GEFS+.

Wikipedia : 74 A febrile seizure, also known as a fever fit or febrile convulsion, is a seizure associated with a high... more...

Related Diseases for Febrile Seizures

Diseases in the Febrile Seizures family:

Febrile Seizures, Familial, 1 Febrile Seizures, Familial, 2
Febrile Seizures, Familial, 4 Febrile Seizures, Familial, 8
Febrile Seizures, Familial, 6 Febrile Seizures, Familial, 5
Febrile Seizures, Familial, 7 Febrile Seizures, Familial, 9
Febrile Seizures, Familial, 10 Febrile Seizures, Familial, 11
Familial Febrile Seizures

Diseases related to Febrile Seizures via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 310)
# Related Disease Score Top Affiliating Genes
1 generalized epilepsy with febrile seizures plus, type 7 35.0 SCN9A SCN1A-AS1
2 generalized epilepsy with febrile seizures plus, type 1 34.8 SCN1B SCN1A
3 febrile seizures, familial, 1 34.5 SCN9A SCN1A-AS1 ADGRV1
4 genetic epilepsy with febrile seizures plus 34.3 SCN9A SCN2A SCN1A
5 familial febrile seizures 33.5 SCN9A SCN1A-AS1 SCN1A GABRG2 ADGRV1
6 seizure disorder 33.2 SCN2A SCN1A
7 benign familial neonatal epilepsy 31.8 SCN2A SCN1A PRRT2
8 generalized epilepsy with febrile seizures plus 31.2 STX1B SCN9A SCN2A SCN1B SCN1A-AS1 SCN1A
9 epileptic encephalopathy, early infantile, 6 31.2 SCN9A SCN2A SCN1B SCN1A PRRT2 GABRG2
10 temporal lobe epilepsy 31.1 SCN1B SCN1A CPA6
11 myoclonic epilepsy of infancy 31.0 SCN1A GABRG2
12 visual epilepsy 30.7 STX1B SCN2A SCN1B SCN1A PRRT2 GABRG2
13 childhood absence epilepsy 30.7 SCN2A SCN1B SCN1A PRRT2 HCN1 GABRG2
14 scn1a seizure disorders 30.6 SCN9A SCN1B SCN1A
15 early myoclonic encephalopathy 30.1 SCN2A SCN1B SCN1A GABRG2 GABRD
16 epilepsy, nocturnal frontal lobe, 1 30.1 SCN1B SCN1A GABRG2
17 gastroenteritis 30.0 SCN1B SCN1A PRRT2
18 epilepsy with generalized tonic-clonic seizures 29.9 SCN2A SCN1B SCN1A GABRG2
19 hemiplegic migraine 29.8 SCN1A PRRT2
20 west syndrome 29.8 SCN2A SCN1B SCN1A GABRG2
21 focal epilepsy 29.8 SCN2A SCN1B SCN1A GABRG2 GABRD CPA6
22 migraine with or without aura 1 29.7 SCN9A SCN2A SCN1A PRRT2
23 benign neonatal seizures 29.6 SCN2A SCN1B SCN1A GABRG2
24 early onset absence epilepsy 29.5 SCN2A SCN1B SCN1A GABRG2
25 brugada syndrome 29.5 SCN9A SCN2A SCN1B SCN1A
26 autosomal dominant nocturnal frontal lobe epilepsy 29.4 SCN2A SCN1B SCN1A GABRG2 GABRD
27 autism spectrum disorder 29.3 SCN2A SCN1A HCN1 GABRG2 GABRD
28 benign familial infantile epilepsy 29.0 SCN2A SCN1B SCN1A PRRT2 GABRG2
29 epilepsy 29.0 STX1B SCN9A SCN2A SCN1B SCN1A-AS1 SCN1A
30 epilepsy, idiopathic generalized 28.7 SCN9A SCN2A SCN1B SCN1A PRRT2 HCN1
31 epilepsy, familial temporal lobe, 5 28.7 SCN9A SCN1B SCN1A GABRG2 GABRD CPA6
32 epilepsy, myoclonic juvenile 28.7 STX1B SCN2A SCN1B SCN1A GABRG2 GABRD
33 generalized epilepsy with febrile seizures plus, type 2 12.9
34 febrile seizures, familial, 8 12.9
35 febrile seizures, familial, 11 12.8
36 febrile seizures, familial, 4 12.8
37 generalized epilepsy with febrile seizures plus, type 9 12.8
38 generalized epilepsy with febrile seizures plus, type 4 12.7
39 generalized epilepsy with febrile seizures plus, type 6 12.7
40 generalized epilepsy with febrile seizures plus, type 10 12.7
41 generalized epilepsy with febrile seizures plus, type 8 12.7
42 febrile seizures, familial, 2 12.7
43 febrile seizures, familial, 6 12.7
44 febrile seizures, familial, 5 12.7
45 febrile seizures, familial, 7 12.7
46 febrile seizures, familial, 9 12.7
47 febrile seizures, familial, 10 12.7
48 mental retardation, keratoconus, febrile seizures, and sinoatrial block 12.5
49 epilepsy, idiopathic generalized 10 12.4
50 exanthema subitum 11.5

Graphical network of the top 20 diseases related to Febrile Seizures:



Diseases related to Febrile Seizures

Symptoms & Phenotypes for Febrile Seizures

UMLS symptoms related to Febrile Seizures:


seizures, fever, other convulsions, symptomatic seizures

MGI Mouse Phenotypes related to Febrile Seizures:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 ADGRV1 CHAT GABRD GABRG2 HCN1 IMPA2
2 nervous system MP:0003631 9.77 ADGRV1 CHAT GABRD GABRG2 HCN1 IMPA2
3 normal MP:0002873 9.23 CHAT GABRG2 HCN1 IMPA2 SCN1A SCN1B

Drugs & Therapeutics for Febrile Seizures

Drugs for Febrile Seizures (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
5
Phenobarbital Approved, Investigational Phase 4 50-06-6 4763
6
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
7
BCG vaccine Investigational Phase 4
8 Tranquilizing Agents Phase 4
9 Anti-Anxiety Agents Phase 4
10 Antiemetics Phase 4
11 Gastrointestinal Agents Phase 4
12 Anesthetics, General Phase 4
13 Psychotropic Drugs Phase 4
14 Anesthetics Phase 4
15 Antioxidants Phase 4
16 Adjuvants, Anesthesia Phase 4
17 Neuromuscular Agents Phase 4
18 Protective Agents Phase 4
19 Anesthetics, Intravenous Phase 4
20 Autonomic Agents Phase 4
21 Vaccines Phase 4
22 Anti-Inflammatory Agents Phase 4
23 Anti-Inflammatory Agents, Non-Steroidal Phase 4
24 Analgesics, Non-Narcotic Phase 4
25 Antipyretics Phase 4
26 Cyclooxygenase Inhibitors Phase 4
27 Antirheumatic Agents Phase 4
28 Analgesics Phase 4
29 Immunologic Factors Phase 4
30 Adjuvants, Immunologic Phase 4
31 Neurotransmitter Agents Phase 4
32 GABA Agents Phase 4
33 Hypnotics and Sedatives Phase 4
34 Anticonvulsants Phase 4
35 GABA Modulators Phase 4
36 Central Nervous System Depressants Phase 4
37 Cytochrome P-450 CYP3A Inducers Phase 4
38 Excitatory Amino Acid Antagonists Phase 4
39 Excitatory Amino Acids Phase 4
40
Phenylalanine Approved, Investigational, Nutraceutical 63-91-2 6140
41 Hemostatics
42 Natriuretic Agents
43 Vasoconstrictor Agents
44 Coagulants
45 Arginine Vasopressin
46 Vasopressins
47 Antibodies
48 Immunoglobulins
49 Heptavalent Pneumococcal Conjugate Vaccine
50
Arginine Investigational, Nutraceutical 74-79-3 6322

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Comparison Between Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures: Randomized Clinical Trial Completed NCT03631901 Phase 4 oral melatonin;oral diazepam
2 Antipyretics for Preventing Recurrences of Febrile Seizures Completed NCT00568217 Phase 4 Diclofenac, Paracetamol, Ibuprofen
3 A Prospective, Randomized, Open-label Clinical Trial to Assess Fever Following Simultaneous Versus Sequential Administration of PCV13, DTaP Vaccine and IIV in Young Children Completed NCT03165981 Phase 4
4 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. A Prospective, Randomised, Clinical Trial. Completed NCT01694108 Phase 4
5 Prophylactic Phenobarbital After Resolution of Neonatal Seizures Terminated NCT01089504 Phase 4 phenobarbital;placebo
6 Efficacy and Safety of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia Completed NCT01373281 Phase 3
7 Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures Terminated NCT01370044 Phase 2, Phase 3 Carbogen;Placebo
8 Investigation of the Respiratory Physiology of Children With and Without Febrile Seizures During Febrile Illness. Unknown status NCT01906619
9 Viral Respiratory and Gastrointestinal Infections in Children Under 6 Years of Age - the Clinical Relevance of Newly Discovered Viruses Unknown status NCT00987519
10 The Relevance of Performing Lumbar Puncture in Infants Aged 3 to 12 Months With First Episode of Febrile Convulsion Completed NCT01443611
11 Pharmacoepidemiological Methodology to Evaluate the Vaccination Risk in Young Infants Completed NCT01931813
12 Nervous System Infections Among Patients With Febrile Seizure : Retrospective Cohort Review of Consecutive Patients Admitted in 7 Pediatric Emergency Departments in Ile-de-France Between 2007 and 2011 Completed NCT01694524
13 Prospective Study on Copeptin in Childhood Epilepsy Completed NCT01884766
14 A Multi-centre, Open-label, Clinical, Phase 4 Trial, Following on From a Head-to-head Comparison Study of Two H1N1 Influenza Vaccines in Children, to Compare Firstly, the Persistence of Antibody Against the A/California/7/2009 (H1N1) Virus and Secondly the Immunogenicity and Reactogenicity of One Dose of a Non-adjuvanted Trivalent Seasonal Influenza Vaccine, in Children Who Had Received a Two-dose Immunisation Regimen of Celvapan or Pandemrix. Completed NCT01239537 Seasonal Flu vaccine
15 Hyperphenylalaninemia in Cerebral Malaria Completed NCT00338520
16 Anthropogenetic Variability in the Group of Individuals With Febrile Seizures Population Genetic Study Recruiting NCT03481764
17 AN OBSERVATIONAL SAFETY STUDY FOR PREVENAR 13 AMONG CHINESE CHILDREN Active, not recruiting NCT03656939
18 Pattern of Pediatric Seizures at Al-Arish Central Hospital - North Sinai Not yet recruiting NCT03374384
19 The DNA and Cell Bank of IFR of Neurosciences: Clinical and Genetic Study of Parkinson's Disease and Epilepsies Terminated NCT00142363

Search NIH Clinical Center for Febrile Seizures

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Phenobarbital
Phenobarbital Sodium

Genetic Tests for Febrile Seizures

Genetic tests related to Febrile Seizures:

# Genetic test Affiliating Genes
1 Febrile Seizures 29

Anatomical Context for Febrile Seizures

MalaCards organs/tissues related to Febrile Seizures:

40
Temporal Lobe, Brain, Testes, Cortex, Thyroid, Eye, Kidney

Publications for Febrile Seizures

Articles related to Febrile Seizures:

(show top 50) (show all 3729)
# Title Authors PMID Year
1
Mechanisms for variable expressivity of inherited SCN1A mutations causing Dravet syndrome. 54 61
20522430 2010
2
Mutations in GABAA receptor subunits associated with genetic epilepsies. 54 61
20308251 2010
3
Generalized epilepsy with febrile seizures plus: novel SCN1A mutation. 54 61
20117752 2010
4
SCN1A mutation screening in adult patients with Lennox-Gastaut syndrome features. 54 61
19782004 2009
5
Advances on the genetics of mendelian idiopathic epilepsies. 54 61
19853223 2009
6
Parental SCN1A mutation mosaicism in familial Dravet syndrome. 54 61
19673951 2009
7
Severe epilepsy syndromes of early childhood: the link between genetics and pathophysiology with a focus on SCN1A mutations. 54 61
19666879 2009
8
[Clinical analysis and screening for SCN1A gene mutation in two pedigrees of generalized epilepsies with febrile seizures plus]. 54 61
19951487 2009
9
Clinical spectrum of SCN1A mutations. 54 61
19469841 2009
10
Dravet syndrome or genetic (generalized) epilepsy with febrile seizures plus? 54 61
19203856 2009
11
Does a SCN1A gene mutation confer earlier age of onset of febrile seizures in GEFS+? 54 61
19292758 2009
12
A novel inherited mutation in the voltage sensor region of SCN1A is associated with Panayiotopoulos syndrome in siblings and generalized epilepsy with febrile seizures plus. 54 61
19339291 2009
13
A splice site variant in the sodium channel gene SCN1A confers risk of febrile seizures. 54 61
19289736 2009
14
The GABRG2 mutation, Q351X, associated with generalized epilepsy with febrile seizures plus, has both loss of function and dominant-negative suppression. 54 61
19261880 2009
15
Novel de novo splice-site mutation of SCN1A in a patient with partial epilepsy with febrile seizures plus. 54 61
18632234 2009
16
Febrile seizures: interleukin 1beta and interleukin-1 receptor antagonist polymorphisms. 54 61
19135625 2009
17
[Analysis of the GABRG2 gene mutation in a Chinese family with generalized epilepsy with febrile seizures plus]. 54 61
19065515 2008
18
Genetic screening of Scandinavian families with febrile seizures and epilepsy or GEFS+. 54 61
17927801 2008
19
[Epilepsy in Israel--2008]. 54 61
18357670 2008
20
SCN1A, SCN1B, and GABRG2 gene mutation analysis in Chinese families with generalized epilepsy with febrile seizures plus. 54 61
18566737 2008
21
Neuropeptide Y gene polymorphism and plasma neuropeptide Y level in febrile seizure patients in Taiwan. 54 61
18055304 2007
22
GEFS+ where focal seizures evolve from generalized spike wave: video-EEG study of two children. 54 61
17884755 2007
23
Idiopathic epilepsies with seizures precipitated by fever and SCN1A abnormalities. 54 61
17561957 2007
24
Association analysis of gamma2 subunit of gamma-aminobutyric acid (GABA) type A receptor and voltage-gated sodium channel type II alpha-polypeptide gene mutation in southern Chinese children with febrile seizures. 54 61
17641256 2007
25
Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures. 54 61
17340635 2007
26
Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. 54 61
17388992 2007
27
Neuropeptide Y: potential role in recurrent developmental seizures. 54 61
17196709 2007
28
Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. 54 61
17068342 2007
29
Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. 54 61
17020904 2007
30
Epilepsy with a de novo missense mutation in the sodium channel a1 subunit: a case report. 54 61
17129991 2006
31
Role of genetics in the diagnosis and treatment of epilepsy. 54 61
17181426 2006
32
Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy-associated SCN1A mutation. 54 61
17065438 2006
33
Familial occurrence of febrile seizures and epilepsy in severe myoclonic epilepsy of infancy (SMEI) patients with SCN1A mutations. 54 61
17054684 2006
34
Na channel gene mutations in epilepsy--the functional consequences. 54 61
16806834 2006
35
A novel GABRG2 mutation associated with febrile seizures. 54 61
16924025 2006
36
Molecular genetics of febrile seizures. 54 61
16887333 2006
37
Increased IL-1beta production from dsRNA-stimulated leukocytes in febrile seizures. 54 61
16876005 2006
38
Phenotypes and genotypes in epilepsy with febrile seizures plus. 54 61
16884893 2006
39
Mutations in GABRA1, GABRA5, GABRG2 and GABRD receptor genes are not a major factor in the pathogenesis of familial focal epilepsy preceded by febrile seizures. 54 61
16256272 2006
40
Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic-clonic seizures. 54 61
16210358 2005
41
A missense mutation in SCN1A in brothers with severe myoclonic epilepsy in infancy (SMEI) inherited from a father with febrile seizures. 54 61
16122630 2005
42
Seizures of idiopathic generalized epilepsies. 54 61
16302874 2005
43
Endogenous neuropeptide Y prevents recurrence of experimental febrile seizures by increasing seizure threshold. 54 61
15800380 2005
44
Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18. 54 61
15557493 2004
45
Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy. 54 61
15263074 2004
46
Febrile convulsions and genetic susceptibility: role of the neuronal nicotinic acetylcholine receptor alpha 4 subunit. 54 61
15101840 2004
47
Clinical correlations of mutations in the SCN1A gene: from febrile seizures to severe myoclonic epilepsy in infancy. 54 61
15087100 2004
48
A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline. 54 61
15028761 2004
49
Generalized epilepsy with febrile seizures plus (GEFS+): clinical spectrum in seven Italian families unrelated to SCN1A, SCN1B, and GABRG2 gene mutations. 54 61
14738422 2004
50
Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A. 54 61
14672992 2003

Variations for Febrile Seizures

ClinVar genetic disease variations for Febrile Seizures:

6 (show all 11) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;X;inv(X)(p11.4q24)dninversion Pathogenic 267883
2 SCN1A NM_006920.6(SCN1A):c.327C>G (p.Tyr109Ter)SNV Pathogenic 437911 rs1553553485 2:166915136-166915136 2:166058626-166058626
3 CHAT NM_020549.4(CHAT):c.2081C>G (p.Ser694Cys)SNV Pathogenic 523529 rs201439531 10:50872926-50872926 10:49664880-49664880
4 SCN1A NM_006920.6(SCN1A):c.3294dup (p.Ser1099fs)duplication Pathogenic 599005 rs1559193213 2:166892659-166892660 2:166036149-166036150
5 GRIN1 NM_007327.4(GRIN1):c.2531G>T (p.Arg844Leu)SNV Likely pathogenic 598966 rs1564365418 9:140058298-140058298 9:137163846-137163846
6 SCN8A NM_001330260.2(SCN8A):c.4235T>C (p.Phe1412Ser)SNV Conflicting interpretations of pathogenicity 523505 rs1555228665 12:52182486-52182486 12:51788702-51788702
7 CHAT NM_020549.4(CHAT):c.1061C>T (p.Thr354Met)SNV Conflicting interpretations of pathogenicity 523528 rs769234940 10:50835781-50835781 10:49627735-49627735
8 AMER1 NM_152424.4(AMER1):c.1907_1908GA[2] (p.Glu637fs)short repeat Uncertain significance 523561 rs1555933313 X:63411255-63411256 X:64191375-64191376
9 46;XY;t(2;10)(p15;p14)dnTranslocation Uncertain significance 268032
10 NF1 NM_000267.3(NF1):c.1987G>A (p.Gly663Arg)SNV Uncertain significance 184278 rs140653372 17:29552254-29552254 17:31225236-31225236
11 TNFRSF1A NM_001065.3(TNFRSF1A):c.434A>G (p.Asn145Ser)SNV Uncertain significance 97703 rs104895288 12:6442571-6442571 12:6333405-6333405

Expression for Febrile Seizures

Search GEO for disease gene expression data for Febrile Seizures.

Pathways for Febrile Seizures

Pathways related to Febrile Seizures according to KEGG:

36
# Name Kegg Source Accession
1 Dopaminergic synapse hsa04728
2 Neuroactive ligand-receptor interaction hsa04080
3 GABAergic synapse hsa04727

GO Terms for Febrile Seizures

Cellular components related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.17 STX1B SEZ6 SCN9A SCN2A SCN1B SCN1A
2 plasma membrane GO:0005886 10.14 STX1B SEZ6 SCN9A SCN2A SCN1B SCN1A
3 integral component of plasma membrane GO:0005887 9.95 SCN9A SCN2A SCN1B HCN1 GABRG2 GABRD
4 cell projection GO:0042995 9.89 SCN9A SCN1B PRRT2 GABRG2 ADGRV1
5 presynapse GO:0098793 9.63 STX1B PRRT2 CHAT
6 intercalated disc GO:0014704 9.54 SCN2A SCN1B SCN1A
7 T-tubule GO:0030315 9.5 SCN2A SCN1B SCN1A
8 node of Ranvier GO:0033268 9.43 SCN2A SCN1B SCN1A
9 sodium channel complex GO:0034706 9.33 SCN2A SCN1B SCN1A
10 voltage-gated sodium channel complex GO:0001518 9.26 SCN9A SCN2A SCN1B SCN1A
11 axon GO:0030424 9.23 STX1B SCN9A SCN2A SCN1B SCN1A PRRT2

Biological processes related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.8 SCN9A SCN2A SCN1A GABRG2 GABRD
2 ion transport GO:0006811 9.8 SCN9A SCN2A SCN1B SCN1A HCN1 GABRG2
3 regulation of membrane potential GO:0042391 9.67 SCN1A HCN1 GABRG2 GABRD
4 nervous system process GO:0050877 9.63 GABRG2 GABRD ADGRV1
5 neuronal action potential GO:0019228 9.61 SCN9A SCN2A SCN1A
6 regulation of ion transmembrane transport GO:0034765 9.55 SCN9A SCN2A SCN1B SCN1A HCN1
7 cardiac muscle cell action potential involved in contraction GO:0086002 9.52 SCN1B SCN1A
8 neuromuscular process controlling posture GO:0050884 9.51 SCN1A PRRT2
9 membrane depolarization during action potential GO:0086010 9.5 SCN9A SCN2A SCN1A
10 synaptic vesicle fusion to presynaptic active zone membrane GO:0031629 9.49 STX1B PRRT2
11 neuronal action potential propagation GO:0019227 9.48 SCN1B SCN1A
12 sodium ion transport GO:0006814 9.35 SCN9A SCN2A SCN1B SCN1A HCN1
13 sodium ion transmembrane transport GO:0035725 9.02 SCN9A SCN2A SCN1B SCN1A HCN1

Molecular functions related to Febrile Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.65 SCN9A SCN2A SCN1B SCN1A HCN1
2 ion channel activity GO:0005216 9.63 SCN9A SCN2A SCN1A HCN1 GABRG2 GABRD
3 sodium channel activity GO:0005272 9.35 SCN9A SCN2A SCN1B SCN1A HCN1
4 GABA-A receptor activity GO:0004890 9.32 GABRG2 GABRD
5 voltage-gated sodium channel activity GO:0005248 9.02 SCN9A SCN2A SCN1B SCN1A HCN1

Sources for Febrile Seizures

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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