Febrile Seizures, Familial, 4 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Febrile Seizures, Familial, 4

MalaCards integrated aliases for Febrile Seizures, Familial, 4:

Name: Febrile Seizures, Familial, 4 ⁵⁷ ⁷³ ²⁹ ¹³ ⁶ ³⁹

Feb4 ⁵⁷ ¹² ⁷³

Familial Febrile Convulsions 4 ¹² ⁷³

Familial Febrile Seizures 4 ¹² ¹⁵

Convulsions, Familial Febrile, 4 ⁵⁷

Characteristics:

OMIM®:

⁵⁷ (Updated 05-Mar-2021)

Inheritance:
autosomal dominant

Miscellaneous:
onset 3 months of age up to 5 years
seizures remit by age 5 years
genetic heterogeneity (see feb1 )
mutation in the mass1 gene has been identified in 1 of 48 families with familial febrile seizures linked to 5q14

HPO:

³¹

febrile seizures, familial, 4:
Inheritance autosomal dominant inheritance heterogeneous
Onset and clinical course infantile onset childhood onset

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0111305

OMIM® ⁵⁷ 604352

OMIM Phenotypic Series ⁵⁷ PS121210

MeSH ⁴⁴ D003294

MedGen ⁴¹ C1858493

SNOMED-CT via HPO ⁶⁸ 189198006 263681008 41497008 more

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Summaries for Febrile Seizures, Familial, 4

UniProtKB/Swiss-Prot : ⁷³ Febrile seizures, familial, 4: Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.

MalaCards based summary : Febrile Seizures, Familial, 4, also known as feb4, is related to seizure disorder and febrile seizures. An important gene associated with Febrile Seizures, Familial, 4 is ADGRV1 (Adhesion G Protein-Coupled Receptor V1), and among its related pathways/superpathways are Nicotine addiction and Interaction between L1 and Ankyrins. Related phenotypes are atonic seizure and bilateral tonic-clonic seizure

Disease Ontology : ¹² A familial febrile seizures that has material basis in heterozygous mutation ADGRV1 on chromosome 5q14.3.

More information from OMIM: 604352 PS121210

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Related Diseases for Febrile Seizures, Familial, 4

Diseases in the Febrile Seizures family:

Febrile Seizures, Familial, 1	Febrile Seizures, Familial, 2
Febrile Seizures, Familial, 4	Febrile Seizures, Familial, 8
Febrile Seizures, Familial, 6	Febrile Seizures, Familial, 5
Febrile Seizures, Familial, 7	Febrile Seizures, Familial, 9
Febrile Seizures, Familial, 10	Febrile Seizures, Familial, 11
Familial Febrile Seizures

Diseases related to Febrile Seizures, Familial, 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)

#	Related Disease	Score	Top Affiliating Genes
1	seizure disorder	29.6	SCN1B SCN1A GABRG2
2	febrile seizures	29.6	SCN1B SCN1A GABRG2 GABRD ADGRV1
3	epilepsy	29.5	SCN1B SCN1A GABRG2 GABRD ADGRV1
4	generalized epilepsy with febrile seizures plus	29.5	SCN1B SCN1A GABRG2 GABRD ADGRV1
5	verbal auditory agnosia	10.2	SCN1B GABRG2
6	myoclonic epilepsy of infancy	10.2	SCN1A GABRG2
7	developmental and epileptic encephalopathy 13	10.2	SCN1B SCN1A
8	reflex epilepsy	10.2	SCN1A GABRG2
9	landau-kleffner syndrome	10.2	SCN1A GABRG2
10	juvenile absence epilepsy	10.2	SCN1A GABRG2
11	infancy electroclinical syndrome	10.2	SCN1B SCN1A
12	benign neonatal seizures	10.1	SCN1B SCN1A
13	sturge-weber syndrome	10.1	SCN1A GABRG2
14	early onset absence epilepsy	10.1	SCN1B SCN1A GABRG2
15	long qt syndrome 3	10.1	SCN1B SCN1A
16	generalized epilepsy with febrile seizures plus, type 1	10.1	SCN1B SCN1A GABRG2
17	epilepsy, nocturnal frontal lobe, 1	10.1	SCN1B SCN1A GABRG2
18	epilepsy, familial temporal lobe, 1	10.1	SCN1B GABRG2 ADGRV1
19	photosensitive epilepsy	10.1	SCN1B SCN1A GABRG2
20	benign familial neonatal epilepsy	10.1	SCN1B SCN1A GABRG2
21	paroxysmal extreme pain disorder	10.1	SCN1B SCN1A
22	benign familial infantile epilepsy	10.1	SCN1B SCN1A GABRG2
23	generalized epilepsy with febrile seizures plus, type 4	10.0	TBC1D22A GABRD
24	unverricht-lundborg syndrome	10.0	SCN1B SCN1A GABRG2 ADGRV1
25	focal epilepsy	10.0	SCN1A GABRG2 GABRD
26	genetic epilepsy with febrile seizures plus	9.9
27	epilepsy with generalized tonic-clonic seizures	9.9	SCN1B SCN1A GABRG2 GABRD
28	adolescence-adult electroclinical syndrome	9.9	SCN1B SCN1A GABRG2 GABRD
29	electroclinical syndrome	9.9	SCN1B SCN1A GABRG2 GABRD
30	childhood electroclinical syndrome	9.9	SCN1B SCN1A GABRG2 GABRD
31	neonatal period electroclinical syndrome	9.9	SCN1B SCN1A GABRG2 GABRD
32	lennox-gastaut syndrome	9.9	SCN1B SCN1A GABRG2 GABRD
33	frontometaphyseal dysplasia	9.9	STT3A ACD
34	paramyotonia congenita of von eulenburg	9.9	SCN1B SCN1A
35	autosomal dominant nocturnal frontal lobe epilepsy	9.9	SCN1B SCN1A GABRG2 GABRD
36	early myoclonic encephalopathy	9.9	SCN1B SCN1A GABRG2 GABRD
37	epilepsy, myoclonic juvenile	9.9	SCN1B SCN1A GABRG2 GABRD
38	dravet syndrome	9.9	SCN1B SCN1A GABRG2 GABRD
39	epilepsy, idiopathic generalized	9.9	SCN1B SCN1A GABRG2 GABRD
40	childhood absence epilepsy	9.9	SCN1B SCN1A GABRG2 GABRD
41	west syndrome	9.9	SCN1B SCN1A GABRG2 GABRD
42	febrile seizures, familial, 6	9.9	TBC1D22A SCN1B SCN1A GABRG2
43	febrile seizures, familial, 5	9.8	TBC1D22A SCN1B SCN1A GABRG2
44	early infantile epileptic encephalopathy	9.8	SCN1B SCN1A GABRG2 GABRD
45	febrile seizures, familial, 1	9.7	TBC1D22A SCN1B SCN1A GABRG2 ADGRV1
46	osteogenesis imperfecta, type x	9.7	VASP STT3A MOB4
47	febrile seizures, familial, 11	9.6	TBC1D22A SCN1A GABRG2 GABRD ADGRV1
48	generalized epilepsy with febrile seizures plus, type 2	9.6	TBC1D22A SCN1B SCN1A GABRG2 GABRD
49	benign epilepsy with centrotemporal spikes	9.6	SCN1B SCN1A GABRG2 GABRD CMIP
50	epilepsy, familial temporal lobe, 5	9.5	TBC1D22A SCN1B SCN1A GABRG2 GABRD ADGRV1

Graphical network of the top 20 diseases related to Febrile Seizures, Familial, 4:

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Symptoms & Phenotypes for Febrile Seizures, Familial, 4

Human phenotypes related to Febrile Seizures, Familial, 4:

³¹

#	Description	HPO Source Accession
1	atonic seizure ³¹	HP:0010819
2	bilateral tonic-clonic seizure ³¹	HP:0002069
3	febrile seizure (within the age range of 3 months to 6 years) ³¹	HP:0002373
4	generalized tonic seizure ³¹	HP:0010818

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 05-Mar-2021)

Neurologic Central Nervous System:
generalized tonic-clonic seizures
seizures, generalized, associated with fever
hypertonic seizures
hypotonic seizures
seizures occur in absence of intracranial infection or defined pathologic or traumatic cause
more

Clinical features from OMIM®:

604352 (Updated 05-Mar-2021)

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Drugs & Therapeutics for Febrile Seizures, Familial, 4

Search Clinical Trials , NIH Clinical Center for Febrile Seizures, Familial, 4

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Genetic Tests for Febrile Seizures, Familial, 4

Genetic tests related to Febrile Seizures, Familial, 4:

#	Genetic test	Affiliating Genes
1	Febrile Seizures, Familial, 4 ²⁹	ADGRV1

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Anatomical Context for Febrile Seizures, Familial, 4

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Publications for Febrile Seizures, Familial, 4

Articles related to Febrile Seizures, Familial, 4:

(show all 15)

#	Title	Authors	PMID	Year
1	A nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures. ⁶¹ ⁵⁷ ⁶	Nakayama J...Ptacek LJ	12402266	2002
2	Genome-wide linkage of febrile seizures and epilepsy to the FEB4 locus at 5q14.3-q23.1 and no MASS1 mutation. ⁶¹ ⁵⁷	Deprez L...De Jonghe P	16273391	2006
3	Significant evidence for linkage of febrile seizures to chromosome 5q14-q15. ⁵⁷ ⁶¹	Nakayama J...Arinami T	10587582	2000
4	Structural variety beyond appearance: high-pressure phases of CrB4 in comparison with FeB4. ⁶¹	Zhang Y...Mao HK	26692374	2016
5	Revealing an unusual transparent phase of superhard iron tetraboride under high pressure. ⁶¹	Kotmool K...Ahuja R	25404295	2014
6	A semiconductive superhard FeB₄ phase from first-principles calculations. ⁶¹	Wang Q...He J	25204967	2014
7	Hardness of FeB4: density functional theory investigation. ⁶¹	Zhang M...Liu H	24811644	2014
8	Structural and relative stabilities, electronic properties, and hardness of iron tetraborides from first prinicples. ⁶¹	Ding LP...Huang XF	24605919	2014
9	The prevalence of Familial Mediterranean Fever common gene mutations in patients with simple febrile seizures. ⁶¹	Ozen F...Ozdemir O	24668705	2014
10	Discovery of a superhard iron tetraboride superconductor. ⁶¹	Gou H...Dubrovinsky L	24160619	2013
11	Interstitial deletion 5q14.3q21.3 with MEF2C haploinsufficiency and mild phenotype: when more is less. ⁶¹	Tonk V...Wilson GN	21567930	2011
12	New superconducting and semiconducting Fe-B compounds predicted with an ab initio evolutionary search. ⁶¹	Kolmogorov AN...Drautz R	21231344	2010
13	Molecular genetics of febrile seizures. ⁶¹	Nakayama J...Arinami T	16887333	2006
14	Molecular genetics of febrile seizures. ⁶¹	Iwasaki N...Arinami T	12383277	2002
15	Autosomal dominant epilepsy with febrile seizures plus with missense mutations of the (Na+)-channel alpha 1 subunit gene, SCN1A. ⁶¹	Ito M...Kaneko S	11823106	2002

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Genes for Febrile Seizures, Familial, 4

Genes related to Febrile Seizures, Familial, 4 (1 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ADGRV1	Adhesion G Protein-Coupled Receptor V1	Protein Coding	1075.81	Molecular basis known ⁵⁷ Pathogenic ⁶ Genetic Tests ²⁹ Unconfirmed association ⁵⁷ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)	12402266
2	SCN1B	Sodium Voltage-Gated Channel Beta Subunit 1	Protein Coding	7.11	DISEASES inferred ¹⁵
3	GABRG2	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma2	Protein Coding	6.86	DISEASES inferred ¹⁵
4	SCN1A	Sodium Voltage-Gated Channel Alpha Subunit 1	Protein Coding	6.52	DISEASES inferred ¹⁵
5	MOB4	MOB Family Member 4, Phocein	Protein Coding	6.28	DISEASES inferred ¹⁵
6	ACD	ACD Shelterin Complex Subunit And Telomerase Recruitment Factor	Protein Coding	6.18	DISEASES inferred ¹⁵
7	NREP	Neuronal Regeneration Related Protein	Protein Coding	5.82	DISEASES inferred ¹⁵
8	GABRD	Gamma-Aminobutyric Acid Type A Receptor Subunit Delta	Protein Coding	5.67	DISEASES inferred ¹⁵
9	LINS1	Lines Homolog 1	Protein Coding	5.59	DISEASES inferred ¹⁵
10	STT3A	STT3 Oligosaccharyltransferase Complex Catalytic Subunit A	Protein Coding	5.52	DISEASES inferred ¹⁵
11	CMIP	C-Maf Inducing Protein	Protein Coding	5.47	DISEASES inferred ¹⁵
12	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	5.38	DISEASES inferred ¹⁵
13	TBC1D22A	TBC1 Domain Family Member 22A	Protein Coding	5.3	DISEASES inferred ¹⁵

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Variations for Febrile Seizures, Familial, 4

ClinVar genetic disease variations for Febrile Seizures, Familial, 4:

⁶ (show all 38)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	ADGRV1	NM_032119.4(ADGRV1):c.6901C>T (p.Gln2301Ter)	SNV	Pathogenic	6798	rs121909762	5:89986808-89986808	5:90690991-90690991
2	ADGRV1	NM_032119.4(ADGRV1):c.17062C>T (p.Arg5688Ter)	SNV	Pathogenic	503694	rs747622607	5:90144496-90144496	5:90848679-90848679
3	ADGRV1	NM_032119.4(ADGRV1):c.8495C>A (p.Ser2832Ter)	SNV	Pathogenic	6797	rs121909761	5:90001325-90001325	5:90705508-90705508
4	ADGRV1	NM_032119.4(ADGRV1):c.2398C>T (p.Arg800Ter)	SNV	Pathogenic	46306	rs373780305	5:89938703-89938703	5:90642886-90642886
5	ADGRV1	NM_032119.4(ADGRV1):c.3151G>T (p.Asp1051Tyr)	SNV	Uncertain significance	46311	rs145556097	5:89943443-89943443	5:90647626-90647626
6	ADGRV1	NM_032119.4(ADGRV1):c.11338C>T (p.Arg3780Cys)	SNV	Uncertain significance	158644	rs201742794	5:90049607-90049607	5:90753790-90753790
7	ADGRV1	NM_032119.4(ADGRV1):c.12032G>T (p.Gly4011Val)	SNV	Uncertain significance	158646	rs369044000	5:90055317-90055317	5:90759500-90759500
8	ADGRV1	NM_032119.4(ADGRV1):c.18273A>G (p.Ala6091=)	SNV	Uncertain significance	100602	rs137853918	5:90368384-90368384	5:91072567-91072567
9	ADGRV1	NM_032119.4(ADGRV1):c.1855T>G (p.Leu619Val)	SNV	Uncertain significance	158649	rs202064612	5:89930946-89930946	5:90635129-90635129
10	ADGRV1	NM_032119.4(ADGRV1):c.2456G>A (p.Ser819Asn)	SNV	Uncertain significance	158650	rs182395524	5:89938761-89938761	5:90642944-90642944
11	ADGRV1	NM_032119.4(ADGRV1):c.3191A>C (p.Glu1064Ala)	SNV	Uncertain significance	46312	rs190922596	5:89943483-89943483	5:90647666-90647666
12	ADGRV1	NM_032119.4(ADGRV1):c.6133G>A (p.Gly2045Arg)	SNV	Uncertain significance	46348	rs41308846	5:89979871-89979871	5:90684054-90684054
13	ADGRV1	NM_032119.4(ADGRV1):c.7413C>A (p.Ser2471Arg)	SNV	Uncertain significance	598769	rs746779681	5:89989986-89989986	5:90694169-90694169
14	ADGRV1	NM_032119.4(ADGRV1):c.14602A>G (p.Ile4868Val)	SNV	Uncertain significance	598770	rs1561765715	5:90098640-90098640	5:90802823-90802823
15	ADGRV1	NM_032119.4(ADGRV1):c.8471G>T (p.Gly2824Val)	SNV	Uncertain significance	598773	rs975296721	5:90001301-90001301	5:90705484-90705484
16	ADGRV1	NM_032119.4(ADGRV1):c.3509A>G (p.Tyr1170Cys)	SNV	Uncertain significance	46318	rs188772875	5:89948255-89948255	5:90652438-90652438
17	ADGRV1	NM_032119.4(ADGRV1):c.3775T>A (p.Ser1259Thr)	SNV	Uncertain significance	46320	rs376900429	5:89949166-89949166	5:90653349-90653349
18	ADGRV1	NM_032119.4(ADGRV1):c.3974C>T (p.Thr1325Met)	SNV	Uncertain significance	546975	rs756414393	5:89949365-89949365	5:90653548-90653548
19	ADGRV1	NM_032119.4(ADGRV1):c.4487A>G (p.Tyr1496Cys)	SNV	Uncertain significance	290823	rs376401006	5:89953830-89953830	5:90658013-90658013
20	ADGRV1	NM_032119.4(ADGRV1):c.5576A>G (p.His1859Arg)	SNV	Uncertain significance	46338	rs200974394	5:89977183-89977183	5:90681366-90681366
21	ADGRV1	NM_032119.4(ADGRV1):c.7571T>A (p.Val2524Glu)	SNV	Uncertain significance	228723	rs191036195	5:89990144-89990144	5:90694327-90694327
22	ADGRV1	NM_032119.4(ADGRV1):c.7873C>T (p.Arg2625Cys)	SNV	Uncertain significance	178958	rs201583659	5:89990446-89990446	5:90694629-90694629
23	ADGRV1	NM_032119.4(ADGRV1):c.8110A>T (p.Ile2704Phe)	SNV	Uncertain significance	46383	rs376318779	5:89992918-89992918	5:90697101-90697101
24	ADGRV1	NM_032119.4(ADGRV1):c.8369A>G (p.Tyr2790Cys)	SNV	Uncertain significance	196987	rs751129081	5:90000288-90000288	5:90704471-90704471
25	ADGRV1	NM_032119.4(ADGRV1):c.9635T>C (p.Ile3212Thr)	SNV	Uncertain significance	290825	rs199833843	5:90016763-90016763	5:90720946-90720946
26	ADGRV1	NM_032119.4(ADGRV1):c.9643G>A (p.Glu3215Lys)	SNV	Uncertain significance	46406	rs199499672	5:90016771-90016771	5:90720954-90720954
27	ADGRV1	NM_032119.4(ADGRV1):c.12128T>C (p.Ile4043Thr)	SNV	Uncertain significance	228706	rs375632680	5:90059129-90059129	5:90763312-90763312
28	ADGRV1	NM_032119.4(ADGRV1):c.12181G>T (p.Val4061Phe)	SNV	Uncertain significance	163601	rs200816323	5:90059182-90059182	5:90763365-90763365
29	ADGRV1	NM_032119.4(ADGRV1):c.12349C>T (p.Arg4117Cys)	SNV	Uncertain significance	198304	rs138908576	5:90070066-90070066	5:90774249-90774249
30	ADGRV1	NM_032119.4(ADGRV1):c.12704A>G (p.Tyr4235Cys)	SNV	Uncertain significance	505865	rs200644004	5:90074281-90074281	5:90778464-90778464
31	ADGRV1	NM_032119.4(ADGRV1):c.12982G>A (p.Glu4328Lys)	SNV	Uncertain significance	439392	rs182452385	5:90074814-90074814	5:90778997-90778997
32	ADGRV1	NM_032119.4(ADGRV1):c.13358A>G (p.His4453Arg)	SNV	Uncertain significance	426807	rs200212083	5:90079067-90079067	5:90783250-90783250
33	ADGRV1	NM_032119.4(ADGRV1):c.13382A>G (p.His4461Arg)	SNV	Uncertain significance	376988	rs182698253	5:90079091-90079091	5:90783274-90783274
34	ADGRV1	NM_032119.4(ADGRV1):c.14303C>T (p.Ser4768Leu)	SNV	Uncertain significance	228711	rs200130204	5:90086949-90086949	5:90791132-90791132
35	ADGRV1	NM_032119.4(ADGRV1):c.14719G>T (p.Val4907Phe)	SNV	Uncertain significance	504584	rs373391623	5:90101158-90101158	5:90805341-90805341
36	ADGRV1	NM_032119.4(ADGRV1):c.15169C>T (p.Pro5057Ser)	SNV	Uncertain significance	285387	rs183633457	5:90106246-90106246	5:90810429-90810429
37	ADGRV1	NM_032119.4(ADGRV1):c.16331C>A (p.Thr5444Lys)	SNV	Uncertain significance	198666	rs370906851	5:90119376-90119376	5:90823559-90823559
38	ADGRV1	NM_032119.4(ADGRV1):c.17758C>A (p.Leu5920Ile)	SNV	Uncertain significance	283512	rs202110635	5:90159576-90159576	5:90863759-90863759

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Expression for Febrile Seizures, Familial, 4

Search GEO for disease gene expression data for Febrile Seizures, Familial, 4.

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Pathways for Febrile Seizures, Familial, 4

Pathways related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Nicotine addiction ³⁶	10.76	GABRG2 GABRD
2	Interaction between L1 and Ankyrins ⁶⁵	10.43	SCN1B SCN1A
3	Synaptic Neurotransmission Pathways: GABAergic Inhibition ⁶⁴	9.85	GABRG2 GABRD

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GO Terms for Febrile Seizures, Familial, 4

Cellular components related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:0030424	9.56	SCN1B SCN1A GABRG2 GABRD
2	chloride channel complex	GO:0034707	9.43	GABRG2 GABRD
3	intercalated disc	GO:0014704	9.4	SCN1B SCN1A
4	T-tubule	GO:0030315	9.37	SCN1B SCN1A
5	GABA-A receptor complex	GO:1902711	9.32	GABRG2 GABRD
6	voltage-gated sodium channel complex	GO:0001518	9.16	SCN1B SCN1A
7	node of Ranvier	GO:0033268	8.96	SCN1B SCN1A
8	sodium channel complex	GO:0034706	8.62	SCN1B SCN1A

Biological processes related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ion transport	GO:0006811	9.67	SCN1B SCN1A GABRG2 GABRD
2	ion transmembrane transport	GO:0034220	9.46	SCN1B SCN1A GABRG2 GABRD
3	regulation of membrane potential	GO:0042391	9.43	SCN1A GABRG2 GABRD
4	cardiac muscle cell action potential involved in contraction	GO:0086002	9.32	SCN1B SCN1A
5	neuronal action potential propagation	GO:0019227	8.96	SCN1B SCN1A
6	nervous system process	GO:0050877	8.8	GABRG2 GABRD ADGRV1

Molecular functions related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:0004888	9.58	GABRG2 GABRD ADGRV1
2	extracellular ligand-gated ion channel activity	GO:0005230	9.37	GABRG2 GABRD
3	ion channel activity	GO:0005216	9.33	SCN1A GABRG2 GABRD
4	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	GO:1904315	9.32	GABRG2 GABRD
5	sodium channel activity	GO:0005272	9.26	SCN1B SCN1A
6	voltage-gated sodium channel activity	GO:0005248	8.96	SCN1B SCN1A
7	GABA-A receptor activity	GO:0004890	8.62	GABRG2 GABRD

Sources

Sources for Febrile Seizures, Familial, 4

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

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Febrile Seizures, Familial, 4 (FEB4)

Aliases & Classifications for Febrile Seizures, Familial, 4

MalaCards integrated aliases for Febrile Seizures, Familial, 4:

Characteristics:

OMIM®:

HPO:

Classifications:

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Summaries for Febrile Seizures, Familial, 4

Related Diseases for Febrile Seizures, Familial, 4

Diseases in the Febrile Seizures family:

Diseases related to Febrile Seizures, Familial, 4 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Febrile Seizures, Familial, 4:

Symptoms & Phenotypes for Febrile Seizures, Familial, 4

Human phenotypes related to Febrile Seizures, Familial, 4:

Symptoms via clinical synopsis from OMIM®:

Clinical features from OMIM®:

Drugs & Therapeutics for Febrile Seizures, Familial, 4

Genetic Tests for Febrile Seizures, Familial, 4

Genetic tests related to Febrile Seizures, Familial, 4:

Anatomical Context for Febrile Seizures, Familial, 4

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Genes for Febrile Seizures, Familial, 4

Genes related to Febrile Seizures, Familial, 4 (1 elite genes):

Variations for Febrile Seizures, Familial, 4

ClinVar genetic disease variations for Febrile Seizures, Familial, 4:

Expression for Febrile Seizures, Familial, 4

Pathways for Febrile Seizures, Familial, 4

Pathways related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

GO Terms for Febrile Seizures, Familial, 4

Cellular components related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

Biological processes related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

Molecular functions related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

Sources for Febrile Seizures, Familial, 4