Febrile Seizures, Familial, 4 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Febrile Seizures, Familial, 4

MalaCards integrated aliases for Febrile Seizures, Familial, 4:

Name: Febrile Seizures, Familial, 4 ⁵⁶ ⁷³ ²⁹ ¹³ ⁶ ³⁹

Feb4 ⁵⁶ ¹² ⁷³

Familial Febrile Convulsions 4 ¹² ⁷³

Familial Febrile Seizures 4 ¹² ¹⁵

Convulsions, Familial Febrile, 4 ⁵⁶

Characteristics:

OMIM:

⁵⁶

Inheritance:
autosomal dominant

Miscellaneous:
onset 3 months of age up to 5 years
seizures remit by age 5 years
genetic heterogeneity (see feb1 )
mutation in the mass1 gene has been identified in 1 of 48 families with familial febrile seizures linked to 5q14

HPO:

³¹

febrile seizures, familial, 4:
Inheritance autosomal dominant inheritance heterogeneous
Onset and clinical course infantile onset childhood onset

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0111305

OMIM ⁵⁶ 604352

OMIM Phenotypic Series ⁵⁶ PS121210

MeSH ⁴³ D003294

MedGen ⁴¹ C1858493

SNOMED-CT via HPO ⁶⁸ 189198006 263681008 41497008 more

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Summaries for Febrile Seizures, Familial, 4

UniProtKB/Swiss-Prot : ⁷³ Febrile seizures, familial, 4: Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.

MalaCards based summary : Febrile Seizures, Familial, 4, also known as feb4, is related to visual epilepsy and febrile seizures. An important gene associated with Febrile Seizures, Familial, 4 is ADGRV1 (Adhesion G Protein-Coupled Receptor V1), and among its related pathways/superpathways are Nicotine addiction and Interaction between L1 and Ankyrins. Related phenotypes are atonic seizure and bilateral tonic-clonic seizure

Disease Ontology : ¹² A familial febrile seizures that has material basis in heterozygous mutation ADGRV1 on chromosome 5q14.3.

More information from OMIM: 604352 PS121210

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Related Diseases for Febrile Seizures, Familial, 4

Diseases in the Febrile Seizures family:

Febrile Seizures, Familial, 1	Febrile Seizures, Familial, 2
Febrile Seizures, Familial, 4	Febrile Seizures, Familial, 8
Febrile Seizures, Familial, 6	Febrile Seizures, Familial, 5
Febrile Seizures, Familial, 7	Febrile Seizures, Familial, 9
Febrile Seizures, Familial, 10	Febrile Seizures, Familial, 11
Familial Febrile Seizures

Diseases related to Febrile Seizures, Familial, 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)

#	Related Disease	Score	Top Affiliating Genes
1	visual epilepsy	30.2	SCN1B SCN1A GABRG2
2	febrile seizures	29.7	SCN1B SCN1A GABRG2 GABRD ADGRV1
3	generalized epilepsy with febrile seizures plus	29.6	SCN1B SCN1A GABRG2 GABRD ADGRV1
4	epilepsy	29.6	SCN1B SCN1A GABRG2 GABRD ADGRV1
5	myoclonic epilepsy of infancy	10.3	SCN1A GABRG2
6	verbal auditory agnosia	10.3	SCN1B GABRG2
7	epileptic encephalopathy, early infantile, 13	10.3	SCN1B SCN1A
8	reflex epilepsy	10.3	SCN1A GABRG2
9	landau-kleffner syndrome	10.3	SCN1A GABRG2
10	juvenile absence epilepsy	10.2	SCN1A GABRG2
11	infancy electroclinical syndrome	10.2	SCN1B SCN1A
12	early onset absence epilepsy	10.2	SCN1B SCN1A GABRG2
13	generalized epilepsy with febrile seizures plus, type 1	10.2	SCN1B SCN1A GABRG2
14	epilepsy, nocturnal frontal lobe, 1	10.2	SCN1B SCN1A GABRG2
15	benign familial neonatal epilepsy	10.2	SCN1B SCN1A GABRG2
16	photosensitive epilepsy	10.2	SCN1B SCN1A GABRG2
17	genetic epilepsy with febrile seizures plus	10.2
18	seizure disorder	10.2
19	benign neonatal seizures	10.2	SCN1B SCN1A GABRG2
20	amyotrophic neuralgia	10.1	SEPTIN14 SEPTIN1
21	benign familial infantile epilepsy	10.1	SCN1B SCN1A GABRG2
22	sturge-weber syndrome	10.1	SCN1A GABRG2
23	brachial plexus neuropathy	10.1	SEPTIN14 SEPTIN1
24	febrile seizures, familial, 7	10.1	RTL8C C11orf40
25	paramyotonia congenita of von eulenburg	10.1	SCN1B SCN1A
26	febrile seizures, familial, 10	10.0	SCN1A RTL8C C11orf40
27	febrile seizures, familial, 6	10.0	SCN1B SCN1A MOB4 GABRG2
28	febrile seizures, familial, 2	10.0	SCN1B SCN1A MOB4 GABRG2
29	febrile seizures, familial, 5	9.9	SCN1B SCN1A RTL8C GABRG2
30	frontometaphyseal dysplasia	9.9	ADGRV1 ACD
31	paroxysmal extreme pain disorder	9.9	SCN1B SCN1A
32	generalized epilepsy with febrile seizures plus, type 2	9.8	SCN1B SCN1A GABRG2 GABRD
33	epilepsy with generalized tonic-clonic seizures	9.8	SCN1B SCN1A GABRG2 GABRD
34	adolescence-adult electroclinical syndrome	9.8	SCN1B SCN1A GABRG2 GABRD
35	electroclinical syndrome	9.7	SCN1B SCN1A GABRG2 GABRD
36	childhood electroclinical syndrome	9.7	SCN1B SCN1A GABRG2 GABRD
37	neonatal period electroclinical syndrome	9.7	SCN1B SCN1A GABRG2 GABRD
38	lennox-gastaut syndrome	9.7	SCN1B SCN1A GABRG2 GABRD
39	autosomal dominant nocturnal frontal lobe epilepsy	9.7	SCN1B SCN1A GABRG2 GABRD
40	early myoclonic encephalopathy	9.7	SCN1B SCN1A GABRG2 GABRD
41	epileptic encephalopathy, early infantile, 6	9.7	SCN1B SCN1A GABRG2 GABRD
42	epilepsy, myoclonic juvenile	9.7	SCN1B SCN1A GABRG2 GABRD
43	childhood absence epilepsy	9.7	SCN1B SCN1A GABRG2 GABRD
44	epilepsy, idiopathic generalized	9.7	SCN1B SCN1A GABRG2 GABRD
45	focal epilepsy	9.7	SCN1B SCN1A GABRG2 GABRD
46	west syndrome	9.7	SCN1B SCN1A GABRG2 GABRD
47	early infantile epileptic encephalopathy	9.7	SCN1B SCN1A GABRG2 GABRD
48	generalized epilepsy with febrile seizures plus, type 7	9.6	SCN1B SCN1A GABRG2 GABRD ADGRV1
49	epilepsy, familial temporal lobe, 5	9.6	SCN1B SCN1A GABRG2 GABRD ADGRV1
50	febrile seizures, familial, 11	9.4	SEPTIN14 SCN1A RTL8C GABRG2 GABRD

Graphical network of the top 20 diseases related to Febrile Seizures, Familial, 4:

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Symptoms & Phenotypes for Febrile Seizures, Familial, 4

Human phenotypes related to Febrile Seizures, Familial, 4:

³¹

#	Description	HPO Source Accession
1	atonic seizure ³¹	HP:0010819
2	bilateral tonic-clonic seizure ³¹	HP:0002069
3	febrile seizure (within the age range of 3 months to 6 years) ³¹	HP:0002373
4	generalized tonic seizure ³¹	HP:0010818

Symptoms via clinical synopsis from OMIM:

⁵⁶

Neurologic Central Nervous System:
generalized tonic-clonic seizures
seizures, generalized, associated with fever
hypertonic seizures
hypotonic seizures
seizures occur in absence of intracranial infection or defined pathologic or traumatic cause
more

Clinical features from OMIM:

604352

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Drugs & Therapeutics for Febrile Seizures, Familial, 4

Search Clinical Trials , NIH Clinical Center for Febrile Seizures, Familial, 4

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Genetic Tests for Febrile Seizures, Familial, 4

Genetic tests related to Febrile Seizures, Familial, 4:

#	Genetic test	Affiliating Genes
1	Febrile Seizures, Familial, 4 ²⁹	ADGRV1

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Anatomical Context for Febrile Seizures, Familial, 4

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Publications for Febrile Seizures, Familial, 4

Articles related to Febrile Seizures, Familial, 4:

(show all 15)

#	Title	Authors	PMID	Year
1	A nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures. ⁵⁶ ⁶ ⁶¹	Nakayama J...Ptacek LJ	12402266	2002
2	Genome-wide linkage of febrile seizures and epilepsy to the FEB4 locus at 5q14.3-q23.1 and no MASS1 mutation. ⁵⁶ ⁶¹	Deprez L...De Jonghe P	16273391	2006
3	Significant evidence for linkage of febrile seizures to chromosome 5q14-q15. ⁵⁶ ⁶¹	Nakayama J...Arinami T	10587582	2000
4	Structural variety beyond appearance: high-pressure phases of CrB4 in comparison with FeB4. ⁶¹	Zhang Y...Mao HK	26692374	2016
5	Revealing an unusual transparent phase of superhard iron tetraboride under high pressure. ⁶¹	Kotmool K...Ahuja R	25404295	2014
6	A semiconductive superhard FeB₄ phase from first-principles calculations. ⁶¹	Wang Q...He J	25204967	2014
7	Hardness of FeB4: density functional theory investigation. ⁶¹	Zhang M...Liu H	24811644	2014
8	Structural and relative stabilities, electronic properties, and hardness of iron tetraborides from first prinicples. ⁶¹	Ding LP...Huang XF	24605919	2014
9	The prevalence of Familial Mediterranean Fever common gene mutations in patients with simple febrile seizures. ⁶¹	Ozen F...Ozdemir O	24668705	2014
10	Discovery of a superhard iron tetraboride superconductor. ⁶¹	Gou H...Dubrovinsky L	24160619	2013
11	Interstitial deletion 5q14.3q21.3 with MEF2C haploinsufficiency and mild phenotype: when more is less. ⁶¹	Tonk V...Wilson GN	21567930	2011
12	New superconducting and semiconducting Fe-B compounds predicted with an ab initio evolutionary search. ⁶¹	Kolmogorov AN...Drautz R	21231344	2010
13	Molecular genetics of febrile seizures. ⁶¹	Nakayama J...Arinami T	16887333	2006
14	Autosomal dominant epilepsy with febrile seizures plus with missense mutations of the (Na+)-channel alpha 1 subunit gene, SCN1A. ⁶¹	Ito M...Kaneko S	11823106	2002
15	Molecular genetics of febrile seizures. ⁶¹	Iwasaki N...Arinami T	12383277	2002

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Genes for Febrile Seizures, Familial, 4

Genes related to Febrile Seizures, Familial, 4 (1 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	ADGRV1	Adhesion G Protein-Coupled Receptor V1	Protein Coding	1075.79	Molecular basis known ⁵⁶ Pathogenic ⁶ Genetic Tests ²⁹ Unconfirmed association ⁵⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)	12402266
2	SCN1B	Sodium Voltage-Gated Channel Beta Subunit 1	Protein Coding	6.98	DISEASES inferred ¹⁵
3	GABRG2	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma2	Protein Coding	6.74	DISEASES inferred ¹⁵
4	SCN1A	Sodium Voltage-Gated Channel Alpha Subunit 1	Protein Coding	6.44	DISEASES inferred ¹⁵
5	SEPTIN1	Septin 1	Protein Coding	6.3	DISEASES inferred ¹⁵
6	MOB4	MOB Family Member 4, Phocein	Protein Coding	6.15	DISEASES inferred ¹⁵
7	SCGB2A1	Secretoglobin Family 2A Member 1	Protein Coding	6.15	DISEASES inferred ¹⁵
8	C11orf40	Chromosome 11 Putative Open Reading Frame 40	Protein Coding	5.84	DISEASES inferred ¹⁵
9	SEPTIN14	Septin 14	Protein Coding	5.8	DISEASES inferred ¹⁵
10	RTL8C	Retrotransposon Gag Like 8C	Protein Coding	5.68	DISEASES inferred ¹⁵
11	ACD	ACD Shelterin Complex Subunit And Telomerase Recruitment Factor	Protein Coding	5.68	DISEASES inferred ¹⁵
12	NREP	Neuronal Regeneration Related Protein	Protein Coding	5.63	DISEASES inferred ¹⁵
13	GABRD	Gamma-Aminobutyric Acid Type A Receptor Subunit Delta	Protein Coding	5.57	DISEASES inferred ¹⁵
14	CMIP	C-Maf Inducing Protein	Protein Coding	5.27	DISEASES inferred ¹⁵
15	KRT86	Keratin 86	Protein Coding	5.24	DISEASES inferred ¹⁵

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Variations for Febrile Seizures, Familial, 4

ClinVar genetic disease variations for Febrile Seizures, Familial, 4:

⁶ (show all 38) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	ADGRV1	NM_032119.4(ADGRV1):c.17062C>T (p.Arg5688Ter)	SNV	Pathogenic	503694	rs747622607	5:90144496-90144496	5:90848679-90848679
2	ADGRV1	NM_032119.4(ADGRV1):c.8495C>A (p.Ser2832Ter)	SNV	Pathogenic	6797	rs121909761	5:90001325-90001325	5:90705508-90705508
3	ADGRV1	NM_032119.4(ADGRV1):c.2398C>T (p.Arg800Ter)	SNV	Pathogenic	46306	rs373780305	5:89938703-89938703	5:90642886-90642886
4	ADGRV1	NM_032119.4(ADGRV1):c.6901C>T (p.Gln2301Ter)	SNV	Pathogenic/Likely pathogenic	6798	rs121909762	5:89986808-89986808	5:90690991-90690991
5	ADGRV1	NM_032119.4(ADGRV1):c.18273A>G (p.Ala6091=)	SNV	Conflicting interpretations of pathogenicity	100602	rs137853918	5:90368384-90368384	5:91072567-91072567
6	ADGRV1	NM_032119.4(ADGRV1):c.1855T>G (p.Leu619Val)	SNV	Conflicting interpretations of pathogenicity	158649	rs202064612	5:89930946-89930946	5:90635129-90635129
7	ADGRV1	NM_032119.4(ADGRV1):c.2456G>A (p.Ser819Asn)	SNV	Conflicting interpretations of pathogenicity	158650	rs182395524	5:89938761-89938761	5:90642944-90642944
8	ADGRV1	NM_032119.4(ADGRV1):c.3151G>T (p.Asp1051Tyr)	SNV	Conflicting interpretations of pathogenicity	46311	rs145556097	5:89943443-89943443	5:90647626-90647626
9	ADGRV1	NM_032119.4(ADGRV1):c.3191A>C (p.Glu1064Ala)	SNV	Conflicting interpretations of pathogenicity	46312	rs190922596	5:89943483-89943483	5:90647666-90647666
10	ADGRV1	NM_032119.4(ADGRV1):c.6133G>A (p.Gly2045Arg)	SNV	Conflicting interpretations of pathogenicity	46348	rs41308846	5:89979871-89979871	5:90684054-90684054
11	ADGRV1	NM_032119.4(ADGRV1):c.12128T>C (p.Ile4043Thr)	SNV	Conflicting interpretations of pathogenicity	228706	rs375632680	5:90059129-90059129	5:90763312-90763312
12	ADGRV1	NM_032119.4(ADGRV1):c.17758C>A (p.Leu5920Ile)	SNV	Conflicting interpretations of pathogenicity	283512	rs202110635	5:90159576-90159576	5:90863759-90863759
13	ADGRV1	NM_032119.4(ADGRV1):c.4487A>G (p.Tyr1496Cys)	SNV	Conflicting interpretations of pathogenicity	290823	rs376401006	5:89953830-89953830	5:90658013-90658013
14	ADGRV1	NM_032119.4(ADGRV1):c.9635T>C (p.Ile3212Thr)	SNV	Conflicting interpretations of pathogenicity	290825	rs199833843	5:90016763-90016763	5:90720946-90720946
15	ADGRV1	NM_032119.4(ADGRV1):c.13382A>G (p.His4461Arg)	SNV	Uncertain significance	376988	rs182698253	5:90079091-90079091	5:90783274-90783274
16	ADGRV1	NM_032119.4(ADGRV1):c.15169C>T (p.Pro5057Ser)	SNV	Uncertain significance	285387	rs183633457	5:90106246-90106246	5:90810429-90810429
17	ADGRV1	NM_032119.4(ADGRV1):c.14303C>T (p.Ser4768Leu)	SNV	Uncertain significance	228711	rs200130204	5:90086949-90086949	5:90791132-90791132
18	ADGRV1	NM_032119.4(ADGRV1):c.8110A>T (p.Ile2704Phe)	SNV	Uncertain significance	46383	rs376318779	5:89992918-89992918	5:90697101-90697101
19	ADGRV1	NM_032119.4(ADGRV1):c.9643G>A (p.Glu3215Lys)	SNV	Uncertain significance	46406	rs199499672	5:90016771-90016771	5:90720954-90720954
20	ADGRV1	NM_032119.4(ADGRV1):c.3509A>G (p.Tyr1170Cys)	SNV	Uncertain significance	46318	rs188772875	5:89948255-89948255	5:90652438-90652438
21	ADGRV1	NM_032119.4(ADGRV1):c.3775T>A (p.Ser1259Thr)	SNV	Uncertain significance	46320	rs376900429	5:89949166-89949166	5:90653349-90653349
22	ADGRV1	NM_032119.4(ADGRV1):c.5576A>G (p.His1859Arg)	SNV	Uncertain significance	46338	rs200974394	5:89977183-89977183	5:90681366-90681366
23	ADGRV1	NM_032119.4(ADGRV1):c.11338C>T (p.Arg3780Cys)	SNV	Uncertain significance	158644	rs201742794	5:90049607-90049607	5:90753790-90753790
24	ADGRV1	NM_032119.4(ADGRV1):c.12032G>T (p.Gly4011Val)	SNV	Uncertain significance	158646	rs369044000	5:90055317-90055317	5:90759500-90759500
25	ADGRV1	NM_032119.4(ADGRV1):c.7873C>T (p.Arg2625Cys)	SNV	Uncertain significance	178958	rs201583659	5:89990446-89990446	5:90694629-90694629
26	ADGRV1	NM_032119.4(ADGRV1):c.12181G>T (p.Val4061Phe)	SNV	Uncertain significance	163601	rs200816323	5:90059182-90059182	5:90763365-90763365
27	ADGRV1	NM_032119.4(ADGRV1):c.8369A>G (p.Tyr2790Cys)	SNV	Uncertain significance	196987	rs751129081	5:90000288-90000288	5:90704471-90704471
28	ADGRV1	NM_032119.4(ADGRV1):c.12349C>T (p.Arg4117Cys)	SNV	Uncertain significance	198304	rs138908576	5:90070066-90070066	5:90774249-90774249
29	ADGRV1	NM_032119.4(ADGRV1):c.16331C>A (p.Thr5444Lys)	SNV	Uncertain significance	198666	rs370906851	5:90119376-90119376	5:90823559-90823559
30	ADGRV1	NM_032119.4(ADGRV1):c.7571T>A (p.Val2524Glu)	SNV	Uncertain significance	228723	rs191036195	5:89990144-89990144	5:90694327-90694327
31	ADGRV1	NM_032119.4(ADGRV1):c.13358A>G (p.His4453Arg)	SNV	Uncertain significance	426807	rs200212083	5:90079067-90079067	5:90783250-90783250
32	ADGRV1	NM_032119.4(ADGRV1):c.12982G>A (p.Glu4328Lys)	SNV	Uncertain significance	439392	rs182452385	5:90074814-90074814	5:90778997-90778997
33	ADGRV1	NM_032119.4(ADGRV1):c.12704A>G (p.Tyr4235Cys)	SNV	Uncertain significance	505865	rs200644004	5:90074281-90074281	5:90778464-90778464
34	ADGRV1	NM_032119.4(ADGRV1):c.14719G>T (p.Val4907Phe)	SNV	Uncertain significance	504584	rs373391623	5:90101158-90101158	5:90805341-90805341
35	ADGRV1	NM_032119.4(ADGRV1):c.3974C>T (p.Thr1325Met)	SNV	Uncertain significance	546975	rs756414393	5:89949365-89949365	5:90653548-90653548
36	ADGRV1	NM_032119.4(ADGRV1):c.7413C>A (p.Ser2471Arg)	SNV	Uncertain significance	598769	rs746779681	5:89989986-89989986	5:90694169-90694169
37	ADGRV1	NM_032119.4(ADGRV1):c.8471G>T (p.Gly2824Val)	SNV	Uncertain significance	598773	rs975296721	5:90001301-90001301	5:90705484-90705484
38	ADGRV1	NM_032119.4(ADGRV1):c.14602A>G (p.Ile4868Val)	SNV	Uncertain significance	598770	rs1561765715	5:90098640-90098640	5:90802823-90802823

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Expression for Febrile Seizures, Familial, 4

Search GEO for disease gene expression data for Febrile Seizures, Familial, 4.

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Pathways for Febrile Seizures, Familial, 4

Pathways related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Nicotine addiction ³⁶	10.76	GABRG2 GABRD
2	Interaction between L1 and Ankyrins ⁶⁵	10.43	SCN1B SCN1A
3	Synaptic Neurotransmission: GABAergic Inhibition ⁶⁴	9.85	GABRG2 GABRD

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GO Terms for Febrile Seizures, Familial, 4

Cellular components related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:0030424	9.71	SCN1B SCN1A GABRG2 GABRD
2	cell division site	GO:0032153	9.43	SEPTIN14 SEPTIN1
3	GABA-A receptor complex	GO:1902711	9.37	GABRG2 GABRD
4	voltage-gated sodium channel complex	GO:0001518	9.32	SCN1B SCN1A
5	node of Ranvier	GO:0033268	9.26	SCN1B SCN1A
6	septin complex	GO:0031105	9.16	SEPTIN14 SEPTIN1
7	septin ring	GO:0005940	8.96	SEPTIN14 SEPTIN1
8	sodium channel complex	GO:0034706	8.62	SCN1B SCN1A

Biological processes related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of membrane potential	GO:0042391	9.33	GABRD GABRG2 SCN1A
2	cytoskeleton-dependent cytokinesis	GO:0061640	9.32	SEPTIN1 SEPTIN14
3	cardiac muscle cell action potential involved in contraction	GO:0086002	9.26	SCN1A SCN1B
4	neuronal action potential propagation	GO:0019227	8.96	SCN1A SCN1B
5	nervous system process	GO:0050877	8.8	ADGRV1 GABRD GABRG2

Molecular functions related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ion channel activity	GO:0005216	9.43	SCN1A GABRG2 GABRD
2	sodium channel activity	GO:0005272	9.16	SCN1B SCN1A
3	voltage-gated sodium channel activity	GO:0005248	8.96	SCN1B SCN1A
4	GABA-A receptor activity	GO:0004890	8.62	GABRG2 GABRD

Sources

Sources for Febrile Seizures, Familial, 4

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

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Febrile Seizures, Familial, 4 (FEB4)

Aliases & Classifications for Febrile Seizures, Familial, 4

MalaCards integrated aliases for Febrile Seizures, Familial, 4:

Characteristics:

OMIM:

HPO:

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Summaries for Febrile Seizures, Familial, 4

Related Diseases for Febrile Seizures, Familial, 4

Diseases in the Febrile Seizures family:

Diseases related to Febrile Seizures, Familial, 4 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Febrile Seizures, Familial, 4:

Symptoms & Phenotypes for Febrile Seizures, Familial, 4

Human phenotypes related to Febrile Seizures, Familial, 4:

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Drugs & Therapeutics for Febrile Seizures, Familial, 4

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Genes for Febrile Seizures, Familial, 4

Genes related to Febrile Seizures, Familial, 4 (1 elite genes):

Variations for Febrile Seizures, Familial, 4

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Expression for Febrile Seizures, Familial, 4

Pathways for Febrile Seizures, Familial, 4

Pathways related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

GO Terms for Febrile Seizures, Familial, 4

Cellular components related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

Biological processes related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

Molecular functions related to Febrile Seizures, Familial, 4 according to GeneCards Suite gene sharing:

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