MCID: FML006
MIFTS: 20

Female Breast Central Part Cancer

Categories: Cancer diseases

Aliases & Classifications for Female Breast Central Part Cancer

MalaCards integrated aliases for Female Breast Central Part Cancer:

Name: Female Breast Central Part Cancer 12 15
Malignant Neoplasm of Central Portion of Female Breast 12
Malignant Neoplasm of Central Part of Female Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13799
ICD9CM 34 174.1
SNOMED-CT 67 188151006
ICD10 32 C50.11
UMLS 71 C0153549

Summaries for Female Breast Central Part Cancer

Disease Ontology : 12 A female breast cancer that is located in the center of the breast.

MalaCards based summary : Female Breast Central Part Cancer, also known as malignant neoplasm of central portion of female breast, is related to impotence and cerebral palsy. An important gene associated with Female Breast Central Part Cancer is NOS1 (Nitric Oxide Synthase 1), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and VEGF Signaling. Affiliated tissues include center of the breast and breast, and related phenotypes are Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation and renal/urinary system

Related Diseases for Female Breast Central Part Cancer

Diseases related to Female Breast Central Part Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 impotence 9.4 NOS2 NOS1
2 cerebral palsy 9.4 NOS2 NOS1
3 constipation 9.3 NOS2 NOS1
4 ischemia 9.2 NOS2 NOS1
5 female breast upper-inner quadrant cancer 9.1 NOS2 NOS1 CD2AP

Graphical network of the top 20 diseases related to Female Breast Central Part Cancer:



Diseases related to Female Breast Central Part Cancer

Symptoms & Phenotypes for Female Breast Central Part Cancer

GenomeRNAi Phenotypes related to Female Breast Central Part Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 8.62 NOS1 NOS2

MGI Mouse Phenotypes related to Female Breast Central Part Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.8 CD2AP NOS1 NOS2

Drugs & Therapeutics for Female Breast Central Part Cancer

Search Clinical Trials , NIH Clinical Center for Female Breast Central Part Cancer

Genetic Tests for Female Breast Central Part Cancer

Anatomical Context for Female Breast Central Part Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Female Breast Central Part Cancer:

19
Center Of The Breast

MalaCards organs/tissues related to Female Breast Central Part Cancer:

40
Breast

Publications for Female Breast Central Part Cancer

Variations for Female Breast Central Part Cancer

Expression for Female Breast Central Part Cancer

Search GEO for disease gene expression data for Female Breast Central Part Cancer.

Pathways for Female Breast Central Part Cancer

Pathways related to Female Breast Central Part Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.09 NOS2 NOS1
2
Show member pathways
12.01 NOS2 NOS1
3
Show member pathways
11.99 NOS2 NOS1
4
Show member pathways
11.83 NOS2 NOS1
5
Show member pathways
11.79 NOS2 NOS1
6 11.63 NOS2 NOS1
7 11.56 NOS2 NOS1
8
Show member pathways
11.23 NOS2 NOS1
9
Show member pathways
11.19 NOS2 NOS1
10
Show member pathways
11.03 NOS2 NOS1
11
Show member pathways
10.97 NOS2 NOS1
12 10.77 NOS2 NOS1
13
Show member pathways
10.67 NOS2 NOS1
14 10.54 NOS2 NOS1
15 10.07 NOS2 NOS1
16 9.53 NOS2 NOS1

GO Terms for Female Breast Central Part Cancer

Cellular components related to Female Breast Central Part Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 9.13 NOS2 NOS1 CD2AP
2 vesicle membrane GO:0012506 8.62 NOS2 NOS1

Biological processes related to Female Breast Central Part Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.48 NOS2 NOS1
2 response to lipopolysaccharide GO:0032496 9.46 NOS2 NOS1
3 cell redox homeostasis GO:0045454 9.43 NOS2 NOS1
4 response to hormone GO:0009725 9.4 NOS2 NOS1
5 negative regulation of blood pressure GO:0045776 9.37 NOS2 NOS1
6 nitric oxide mediated signal transduction GO:0007263 9.32 NOS2 NOS1
7 nitric oxide biosynthetic process GO:0006809 9.26 NOS2 NOS1
8 positive regulation of guanylate cyclase activity GO:0031284 9.16 NOS2 NOS1
9 arginine catabolic process GO:0006527 8.96 NOS2 NOS1
10 peptidyl-cysteine S-nitrosylation GO:0018119 8.62 NOS2 NOS1

Molecular functions related to Female Breast Central Part Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.48 NOS2 NOS1
2 heme binding GO:0020037 9.46 NOS2 NOS1
3 flavin adenine dinucleotide binding GO:0050660 9.43 NOS2 NOS1
4 NADP binding GO:0050661 9.4 NOS2 NOS1
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.37 NOS2 NOS1
6 FMN binding GO:0010181 9.32 NOS2 NOS1
7 arginine binding GO:0034618 9.26 NOS2 NOS1
8 NADPH-hemoprotein reductase activity GO:0003958 9.16 NOS2 NOS1
9 tetrahydrobiopterin binding GO:0034617 8.96 NOS2 NOS1
10 nitric-oxide synthase activity GO:0004517 8.62 NOS2 NOS1

Sources for Female Breast Central Part Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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