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MCID: FML005
MIFTS: 41

Female Reproductive Endometrioid Cancer

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Female Reproductive Endometrioid Cancer

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MalaCards integrated aliases for Female Reproductive Endometrioid Cancer:

Name: Female Reproductive Endometrioid Cancer 12 15
Endometrioid Tumor 12 29 73
Female Reproductive Endometrioid Neoplasm 12
Carcinoma Endometrioid 55
Endometrioid Neoplasm 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3001
NCIt 50 C7113
SNOMED-CT 68 253013001
UMLS 73 C0474809
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Summaries for Female Reproductive Endometrioid Cancer

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MalaCards based summary : Female Reproductive Endometrioid Cancer, also known as endometrioid tumor, is related to endometrial adenocarcinoma and endometrial cancer. An important gene associated with Female Reproductive Endometrioid Cancer is KRT7 (Keratin 7), and among its related pathways/superpathways are Development HGF signaling pathway and Kaposi's sarcoma-associated herpesvirus infection. The drugs Hormones and taxane have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related phenotypes are Decreased sensitivity to paclitaxel and Increased cell death HMECs cells

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Related Diseases for Female Reproductive Endometrioid Cancer

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Diseases related to Female Reproductive Endometrioid Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 endometrial adenocarcinoma 29.9 KRT7 PGR PTEN TP53
2 endometrial cancer 29.1 CTNNB1 KRT7 PGR PTEN TP53
3 endometrioid ovary carcinoma 11.1
4 fallopian tube endometrioid adenocarcinoma 11.0
5 renal adenoma 10.6 KRT7 WT1
6 epithelial predominant wilms' tumor 10.5 KRT7 WT1
7 metanephric adenoma 10.5 KRT7 WT1
8 adenomatoid tumor 10.5 KRT7 WT1
9 malignant biphasic mesothelioma 10.5 KRT7 WT1
10 urethral diverticulum 10.5 KRT7 WT1
11 ovarian mucinous neoplasm 10.5 KRT7 WT1
12 large intestine adenocarcinoma 10.5 CTNNB1 KRT7
13 lung acinar adenocarcinoma 10.5 CTNNB1 KRT7
14 papillary craniopharyngioma 10.5 CTNNB1 KRT7
15 adenomyoma 10.5 CTNNB1 KRT7
16 benign mesothelioma 10.5 KRT7 WT1
17 bladder adenocarcinoma 10.5 CTNNB1 KRT7
18 nephrogenic adenofibroma 10.5 KRT7 WT1
19 pulmonary sclerosing hemangioma 10.5 CTNNB1 KRT7
20 ovarian brenner tumor 10.4 KRT7 WT1
21 sclerosing hemangioma 10.4 CTNNB1 KRT7
22 cystitis cystica 10.4 CTNNB1 KRT7
23 chronic leukemia 10.4 PTEN WT1
24 malignant spiradenoma 10.4 KRT7 TP53
25 eccrine sweat gland neoplasm 10.4 KRT7 TP53
26 bladder carcinoma in situ 10.3 KRT7 TP53
27 nasal cavity adenocarcinoma 10.3 KRT7 TP53
28 spiradenoma 10.3 KRT7 TP53
29 pleomorphic carcinoma 10.3 KRT7 TP53
30 biliary papillomatosis 10.3 KRT7 TP53
31 cerebellar angioblastoma 10.3 TP53 WT1
32 endocervical adenocarcinoma 10.3 KRT7 TP53
33 prostate squamous cell carcinoma 10.3 KRT7 TP53
34 ovary adenocarcinoma 10.3 KRT7 TP53
35 epithelial-myoepithelial carcinoma 10.3 KRT7 TP53
36 necrotizing sialometaplasia 10.3 KRT7 TP53
37 birt-hogg-dube syndrome 10.3 CTNNB1 PTEN
38 cystic teratoma 10.3 KRT7 TP53
39 basaloid squamous cell carcinoma 10.3 KRT7 TP53
40 biliary tract neoplasm 10.3 KRT7 TP53
41 inverted papilloma 10.3 KRT7 TP53
42 granulosa cell tumor of the ovary 10.3 KRT7 TP53
43 wilms tumor 5 10.3 CTNNB1 WT1
44 hidradenocarcinoma 10.3 KRT7 TP53
45 pseudomyxoma peritonei 10.3 KRT7 TP53
46 vulva cancer 10.3 KRT7 TP53
47 persistent mullerian duct syndrome 10.3 CTNNB1 WT1
48 bile duct adenocarcinoma 10.2 KRT7 TP53
49 germ cell and embryonal cancer 10.2 KRT7 TP53
50 adult hepatocellular carcinoma 10.2 CTNNB1 TP53

Graphical network of the top 20 diseases related to Female Reproductive Endometrioid Cancer:



Diseases related to Female Reproductive Endometrioid Cancer
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Symptoms & Phenotypes for Female Reproductive Endometrioid Cancer

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GenomeRNAi Phenotypes related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.96 PTEN WT1
2 Increased cell death HMECs cells GR00103-A-0 8.92 CTNNB1 PGR PTEN TP53

MGI Mouse Phenotypes related to Female Reproductive Endometrioid Cancer:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.99 WT1 PTEN CTNNB1 TP53 KRT7 PGR
2 homeostasis/metabolism MP:0005376 9.93 PGR PTEN CTNNB1 KRT7 TP53 WT1
3 cardiovascular system MP:0005385 9.92 PGR PTEN CTNNB1 TP53 WT1
4 embryo MP:0005380 9.89 PTEN CTNNB1 TP53 PGR WT1
5 endocrine/exocrine gland MP:0005379 9.88 PTEN CTNNB1 TP53 PGR WT1
6 muscle MP:0005369 9.77 WT1 PTEN CTNNB1 TP53 PGR
7 limbs/digits/tail MP:0005371 9.73 PGR PTEN CTNNB1 TP53
8 neoplasm MP:0002006 9.72 WT1 PTEN CTNNB1 TP53 PGR
9 liver/biliary system MP:0005370 9.71 PTEN CTNNB1 TP53 WT1
10 no phenotypic analysis MP:0003012 9.56 PGR CTNNB1 TP53 WT1
11 normal MP:0002873 9.55 PTEN CTNNB1 TP53 PGR WT1
12 renal/urinary system MP:0005367 9.35 WT1 PTEN CTNNB1 TP53 KRT7
13 reproductive system MP:0005389 9.02 PTEN CTNNB1 TP53 PGR WT1
Sources

Drugs & Therapeutics for Female Reproductive Endometrioid Cancer

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Drugs for Female Reproductive Endometrioid Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 4,Phase 2,Phase 1
2 taxane Phase 4
3
Carboplatin Approved Phase 3,Phase 1,Phase 2 41575-94-4 10339178 498142 38904
4
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
5
Gemcitabine Approved Phase 3,Phase 1,Phase 2 95058-81-4 60750
6
Olaparib Approved Phase 3,Phase 2 763113-22-0 23725625
7
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
8
Cediranib Investigational Phase 3,Phase 2 288383-20-0 9933475
9
Doxil Approved June 1999 Phase 3,Phase 2 31703
10
Maleic acid Experimental Phase 3,Phase 2 110-16-7 444266
11 Albumin-Bound Paclitaxel Phase 3,Phase 2
12 Anti-Bacterial Agents Phase 3,Phase 2
13 Antibiotics, Antitubercular Phase 3,Phase 2
14 Anti-Infective Agents Phase 3,Phase 1,Phase 2
15 Antimetabolites Phase 3,Phase 1,Phase 2
16 Antimetabolites, Antineoplastic Phase 3,Phase 1,Phase 2
17 Antimitotic Agents Phase 3,Phase 2
18 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
19 Antiviral Agents Phase 3,Phase 1,Phase 2
20 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
21 Poly(ADP-ribose) Polymerase Inhibitors Phase 3,Phase 2
22 Protein Kinase Inhibitors Phase 3,Phase 2
23 Topoisomerase Inhibitors Phase 3,Phase 2
24
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
25
Iodine Approved, Investigational Phase 2 7553-56-2 807
26
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
27
Everolimus Approved Phase 2 159351-69-6 6442177
28
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
29
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
30
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
31
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
32 Mitogens Phase 2
33 topoisomerase I inhibitors Phase 2
34 Hormone Antagonists Phase 2,Phase 1
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1
36 Antifungal Agents Phase 2
37 Aromatase Inhibitors Phase 2
38 Estrogen Antagonists Phase 2
39 Estrogens Phase 2
40 Steroid Synthesis Inhibitors Phase 2
41 Antidotes Phase 2
42 Antioxidants Phase 2
43 Expectorants Phase 2
44 N-monoacetylcystine Phase 2
45 Protective Agents Phase 2
46 Respiratory System Agents Phase 2
47 cysteine Nutraceutical Phase 2
48
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
49
Valproic Acid Approved, Investigational Phase 1 99-66-1 3121
50
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1,Not Applicable 59-30-3 6037

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Biomarker Guided Treatment in Gynaecological Cancer Recruiting NCT02543710 Phase 4 Biomarker guided weekly taxane treatment in endometrial/ ovarian cancer
2 Olaparib or Cediranib Maleate and Olaparib Compared With Standard Platinum-Based Chemotherapy in Treating Patients With Recurrent Platinum-Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Recruiting NCT02446600 Phase 3 Carboplatin;Cediranib Maleate;Gemcitabine Hydrochloride;Olaparib;Paclitaxel;Pegylated Liposomal Doxorubicin Hydrochloride
3 Cetuximab in Patients With Progressive or Recurrent Endometrial Cancer Completed NCT00392769 Phase 2 Cetuximab
4 Carboplatin and Gemcitabine Hydrochloride With or Without ATR Kinase Inhibitor VX-970 in Treating Patients With Recurrent and Metastatic Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Recruiting NCT02627443 Phase 1, Phase 2 ATR Kinase Inhibitor M6620;Carboplatin;Gemcitabine Hydrochloride
5 MV-NIS or Investigator's Choice Chemotherapy in Treating Patients With Ovarian, Fallopian, or Peritoneal Cancer Recruiting NCT02364713 Phase 2 Gemcitabine Hydrochloride;Paclitaxel;Pegylated Liposomal Doxorubicin Hydrochloride;Topotecan Hydrochloride
6 Olaparib and Cediranib Maleate in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Active, not recruiting NCT02345265 Phase 2 Cediranib Maleate;Olaparib
7 Study of Ribociclib (LEE011), Everolimus, and Letrozole, in Patients With Advanced or Recurrent Endometrial Carcinoma Active, not recruiting NCT03008408 Phase 2 Ribociclib;Everolimus;Letrozole
8 Effect of Acetylcysteine With Topotecan Hydrochloride on the Tumor Microenvironment in Patients With Persistent or Recurrent High Grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Terminated NCT02569957 Phase 2 Topotecan Hydrochloride;Topotecan Hydrochloride;Acetylcysteine
9 Folate Receptor in Diagnosing Ovarian Cancer Using Serum Samples From Patients With Newly Diagnosed Pelvic Mass or Previously Diagnosed Ovarian Cancer Recruiting NCT02520115 Phase 1 Dexamethasone;Valproic Acid
10 Vaccine Therapy in Treating Patients With Stage IIIC-IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer Following Surgery and Chemotherapy Active, not recruiting NCT02111941 Not Applicable
11 YKL-40 in Serum Samples From Patients With Newly Diagnosed Stage III-IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer Receiving Chemotherapy Terminated NCT00899093

Search NIH Clinical Center for Female Reproductive Endometrioid Cancer

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Genetic Tests for Female Reproductive Endometrioid Cancer

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Genetic tests related to Female Reproductive Endometrioid Cancer:

# Genetic test Affiliating Genes
1 Endometrioid Tumor 29
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Anatomical Context for Female Reproductive Endometrioid Cancer

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MalaCards organs/tissues related to Female Reproductive Endometrioid Cancer:

41
Ovary
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Publications for Female Reproductive Endometrioid Cancer

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Articles related to Female Reproductive Endometrioid Cancer:

# Title Authors Year
1
Endocervical-type mucinous borderline tumors are related to endometrioid tumors based on mutation and loss of expression of ARID1A. ( 22653341 )
2012
2
Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors. ( 19269675 )
2009
3
Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian sertoli cell tumor from endometrioid tumors and carcinoid tumor: A study of 160 cases. ( 17255771 )
2007
4
p16 expression in primary ovarian mucinous and endometrioid tumors and metastatic adenocarcinomas in the ovary: utility for identification of metastatic HPV-related endocervical adenocarcinomas. ( 17460447 )
2007
5
Molecular pathology of endometrial carcinoma: transcriptional signature in endometrioid tumors. ( 16329044 )
2006
6
Histopathologic subtyping of cervical adenocarcinoma reveals increasing incidence rates of endometrioid tumors in all age groups: a population based study with review of all nonsquamous cervical carcinomas in Norway from 1966 to 1970, 1976 to 1980, and 1986 to 1990. ( 11002225 )
2000
7
Expression of E-cadherin and N-cadherin in surface epithelial-stromal tumors of the ovary distinguishes mucinous from serous and endometrioid tumors. ( 9191009 )
1997
8
Ovarian endometrioid tumors with yolk sac tumor component, an unusual form of ovarian neoplasm. Analysis of six cases. ( 8764742 )
1996
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Variations for Female Reproductive Endometrioid Cancer

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Expression for Female Reproductive Endometrioid Cancer

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Search GEO for disease gene expression data for Female Reproductive Endometrioid Cancer.
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Pathways for Female Reproductive Endometrioid Cancer

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Pathways related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Development HGF signaling pathway 22
Show member pathways
 12.28 CTNNB1 PTEN TP53
2
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.1 CTNNB1 PTEN TP53
3
Integrated Breast Cancer Pathway 1
11.62 CTNNB1 PTEN TP53
4
Gastric cancer 37
Show member pathways
 11.59 CTNNB1 PGR PTEN TP53
5
DNA Damage Response (only ATM dependent) 1
11.39 CTNNB1 PTEN TP53
6
Pathways Affected in Adenoid Cystic Carcinoma 1
11.33 PTEN TP53
7
Central carbon metabolism in cancer 37
11.31 PTEN TP53
8
Copper homeostasis 1
11.19 PTEN TP53
9
Glioblastoma Multiforme 64
11.18 CTNNB1 PTEN TP53
10
Integrated Cancer Pathway 1
11.1 PTEN TP53
11
Ovarian tumor domain proteases 66
10.94 PTEN TP53
12
Gastric Cancer Network 2 1
10.84 CTNNB1 TP53
Sources

GO Terms for Female Reproductive Endometrioid Cancer

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Cellular components related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.1 CTNNB1 KRT7 PGR PTEN TP53 WT1

Biological processes related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.63 CTNNB1 PTEN TP53
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.62 CTNNB1 PGR TP53 WT1
3 cell proliferation GO:0008283 9.61 CTNNB1 PTEN TP53
4 positive regulation of apoptotic process GO:0043065 9.58 CTNNB1 PTEN TP53
5 vasculogenesis GO:0001570 9.48 CTNNB1 WT1
6 positive regulation of neuron apoptotic process GO:0043525 9.37 CTNNB1 TP53
7 heart development GO:0007507 9.33 CTNNB1 PTEN WT1
8 branching involved in ureteric bud morphogenesis GO:0001658 9.26 CTNNB1 WT1
9 male genitalia development GO:0030539 8.96 CTNNB1 WT1
10 negative regulation of cell proliferation GO:0008285 8.92 CTNNB1 PTEN TP53 WT1

Molecular functions related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.5 CTNNB1 PTEN TP53
2 DNA binding transcription factor activity GO:0003700 9.46 CTNNB1 PGR TP53 WT1
3 RNA polymerase II transcription factor binding GO:0001085 9.26 CTNNB1 TP53
4 disordered domain specific binding GO:0097718 8.96 CTNNB1 TP53
5 enzyme binding GO:0019899 8.92 CTNNB1 PGR PTEN TP53
Sources

Sources for Female Reproductive Endometrioid Cancer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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