Female Reproductive Endometrioid Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Female Reproductive Endometrioid Cancer

MalaCards integrated aliases for Female Reproductive Endometrioid Cancer:

Name: Female Reproductive Endometrioid Cancer ¹² ¹⁵

Endometrioid Tumor ¹² ²⁹ ⁷³

Female Reproductive Endometrioid Neoplasm ¹²

Carcinoma Endometrioid ⁵⁵

Endometrioid Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3001

NCIt ⁵⁰ C7113

UMLS ⁷³ C0474809

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Summaries for Female Reproductive Endometrioid Cancer

Disease Ontology : ¹² A female reproductive organ cancer that is characterized by a resemblance to endometrium.

MalaCards based summary : Female Reproductive Endometrioid Cancer, also known as endometrioid tumor, is related to endometrial adenocarcinoma and adenocarcinoma. An important gene associated with Female Reproductive Endometrioid Cancer is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways are Pathways in cancer and Development HGF signaling pathway. Affiliated tissues include ovary, lung and brain, and related phenotypes are Decreased viability in esophageal squamous lineage and Decreased sensitivity to paclitaxel

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Related Diseases for Female Reproductive Endometrioid Cancer

Diseases related to Female Reproductive Endometrioid Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)

#	Related Disease	Score	Top Affiliating Genes
1	endometrial adenocarcinoma	30.9	CTNNB1 ESR1 KRT7 PGR PTEN TP53
2	adenocarcinoma	29.8	CTNNB1 PTEN TP53
3	ovarian cancer 1	29.6	KRT7 TP53 WT1
4	sertoli cell tumor	29.6	PGR WT1
5	endometriosis	29.5	ESR1 PGR PTEN
6	cervical adenocarcinoma	29.2	ESR1 KRT7 PGR TP53
7	endometrial cancer	28.8	CTNNB1 ESR1 KRT7 PGR PTEN TP53
8	endometrioid ovary carcinoma	11.3
9	fallopian tube endometrioid adenocarcinoma	11.1
10	mismatch repair cancer syndrome	10.2	CTNNB1 PTEN
11	cystitis cystica	10.2	CTNNB1 KRT7
12	supratentorial cancer	10.2	PTEN TP53
13	giant cell glioblastoma	10.2	PTEN TP53
14	cerebrum cancer	10.2	PTEN TP53
15	gliomatosis cerebri	10.2	PTEN TP53
16	biliary tract neoplasm	10.2	KRT7 TP53
17	endocervical adenocarcinoma	10.2	KRT7 TP53
18	ampulla of vater cancer	10.2	KRT7 TP53
19	appendix cancer	10.2	KRT7 TP53
20	vulva cancer	10.2	KRT7 TP53
21	necrotizing sialometaplasia	10.2	KRT7 TP53
22	eccrine sweat gland neoplasm	10.2	KRT7 TP53
23	sweat gland disease	10.2	KRT7 PGR
24	cystic teratoma	10.2	KRT7 TP53
25	dermoid cyst	10.2	KRT7 PGR
26	germ cell and embryonal cancer	10.2	KRT7 TP53
27	inverted papilloma	10.2	KRT7 TP53
28	pseudomyxoma peritonei	10.2	KRT7 TP53
29	pancreatic ductal carcinoma	10.2	KRT7 TP53
30	lung benign neoplasm	10.2	KRT7 TP53
31	ovary adenocarcinoma	10.2	KRT7 TP53
32	spindle cell carcinoma	10.2	KRT7 PGR
33	adenosquamous carcinoma	10.2	KRT7 TP53
34	bile duct adenocarcinoma	10.2	KRT7 TP53
35	epithelial-myoepithelial carcinoma	10.2	KRT7 TP53
36	breast secretory carcinoma	10.2	KRT7 PGR
37	basaloid squamous cell carcinoma	10.2	KRT7 TP53
38	oropharynx cancer	10.2	KRT7 TP53
39	tonsil cancer	10.2	KRT7 TP53
40	pancreatic mucinous cystadenoma	10.2	KRT7 PGR
41	granulosa cell tumor of the ovary	10.2	KRT7 TP53
42	breast duct papilloma	10.1	PGR PTEN
43	cervical squamous cell carcinoma	10.1	CTNNB1 TP53
44	pharynx cancer	10.1	CTNNB1 TP53
45	tongue disease	10.1	CTNNB1 TP53
46	atypical teratoid rhabdoid tumor	10.1	CTNNB1 TP53
47	cervix disease	10.1	CTNNB1 TP53
48	large intestine adenocarcinoma	10.1	CTNNB1 KRT7
49	intestinal benign neoplasm	10.1	CTNNB1 TP53
50	lung acinar adenocarcinoma	10.1	CTNNB1 KRT7

Graphical network of the top 20 diseases related to Female Reproductive Endometrioid Cancer:

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Symptoms & Phenotypes for Female Reproductive Endometrioid Cancer

GenomeRNAi Phenotypes related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability in esophageal squamous lineage	GR00235-A	9.43	CTNNB1 ESR1 KRT7 PGR PTEN TP53
2	Decreased sensitivity to paclitaxel	GR00112-A-0	9.16	PTEN WT1
3	Increased cell death HMECs cells	GR00103-A-0	8.92	CTNNB1 PGR PTEN TP53

MGI Mouse Phenotypes related to Female Reproductive Endometrioid Cancer:

⁴⁶ (show all 18)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.11	CTNNB1 ESR1 KRT7 PGR PTEN TP53
2	homeostasis/metabolism	MP:0005376	10.07	CTNNB1 ESR1 KRT7 PGR PTEN TP53
3	cardiovascular system	MP:0005385	10.05	CTNNB1 ESR1 PGR PTEN TP53 WT1
4	embryo	MP:0005380	10.03	CTNNB1 ESR1 PGR PTEN TP53 WT1
5	endocrine/exocrine gland	MP:0005379	10.02	CTNNB1 ESR1 PGR PTEN TP53 WT1
6	hematopoietic system	MP:0005397	10.01	CTNNB1 ESR1 PGR PTEN TP53 WT1
7	immune system	MP:0005387	9.99	CTNNB1 ESR1 PGR PTEN TP53 WT1
8	muscle	MP:0005369	9.91	CTNNB1 ESR1 PGR PTEN TP53 WT1
9	integument	MP:0010771	9.89	CTNNB1 ESR1 PGR PTEN TP53
10	limbs/digits/tail	MP:0005371	9.88	CTNNB1 ESR1 PGR PTEN TP53
11	neoplasm	MP:0002006	9.88	CTNNB1 ESR1 PGR PTEN TP53 WT1
12	liver/biliary system	MP:0005370	9.85	CTNNB1 ESR1 PTEN TP53 WT1
13	normal	MP:0002873	9.8	CTNNB1 ESR1 PGR PTEN TP53 WT1
14	no phenotypic analysis	MP:0003012	9.77	CTNNB1 ESR1 PGR TP53 WT1
15	renal/urinary system	MP:0005367	9.73	CTNNB1 ESR1 KRT7 PTEN TP53 WT1
16	reproductive system	MP:0005389	9.63	CTNNB1 ESR1 PGR PTEN TP53 WT1
17	respiratory system	MP:0005388	9.35	CTNNB1 ESR1 PTEN TP53 WT1
18	skeleton	MP:0005390	9.02	CTNNB1 ESR1 PGR PTEN TP53

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Drugs & Therapeutics for Female Reproductive Endometrioid Cancer

Search Clinical Trials , NIH Clinical Center for Female Reproductive Endometrioid Cancer

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Genetic Tests for Female Reproductive Endometrioid Cancer

Genetic tests related to Female Reproductive Endometrioid Cancer:

#	Genetic test	Affiliating Genes
1	Endometrioid Tumor ²⁹

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Anatomical Context for Female Reproductive Endometrioid Cancer

MalaCards organs/tissues related to Female Reproductive Endometrioid Cancer:

⁴¹

Ovary, Lung, Brain, Bone, Tongue, Prostate, Cervix

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Publications for Female Reproductive Endometrioid Cancer

Articles related to Female Reproductive Endometrioid Cancer:

#	Title	Authors	Year
1	Atypical proliferative endometrioid tumor of ovary: Report of a rare case. ( 26497398 )	Jetley S...Jairajpuri ZS	2016
2	Sertoliform Endometrioid Tumor of Ovary Presenting as Torsion. ( 27365921 )	Pai P...Kittur SK	2016
3	Prediction of staging with preoperative parameters and frozen/section in patients with a preoperative diagnosis of grade 1 endometrioid tumor in endometrial cancer. ( 24790516 )	Karalok A...K?se MF	2014
4	Borderline endometrioid tumor arising in a paratubal cyst: a case report. ( 15790473 )	Salamon C...Chi DS	2005
5	Morules with optically clear nuclei in ovarian borderline endometrioid tumor. ( 12588418 )	Li CC...Sano T	2002
6	Androgen-producing, atypically proliferating endometrioid tumor arising in endometriosis. ( 11332919 )	Powell JL...Henderson GS	2001
7	Endometrioid tumor of the ovary with mucinous and serous components. ( 4652772 )	Anderson MC	1972

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Genes for Female Reproductive Endometrioid Cancer

Genes related to Female Reproductive Endometrioid Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PTEN	Phosphatase And Tensin Homolog	Protein Coding	23.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	18653908 12405911 11156411 (more) 15668893 12766611 11873308 11949955 11197771 9699651 15584653 16793127 16676097 14976538 12866376 16429393 19930726 16803539 18035676 15492994 16776856 17062663 18977806 15761464
2	KRT7	Keratin 7	Protein Coding	22.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	9656124 8933513 14571433
3	CTNNB1	Catenin Beta 1	Protein Coding	22.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	19820688 10433945 15668893 (more) 18295959 16021566 12379748 18607832 11957146 11161379 15761464 15785075 16429393 20396392 11048799 14747944 16776856 15262114 15492994 18035676
4	TP53	Tumor Protein P53	Protein Coding	22.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	8972476 8156496 9744308 (more) 11324501 11419970 9421074 9474874 19623034 11873308 11349218 20003326 15084839 7590703 14595509 8602616 16175073 8626128 16510175 7942635 8625241 15634502 11710596 10479512 8972757 8626141 14976538 15761464 14747944 10786803 9635673 19435786 12496703 9740709 17581423 15894417 16174251 18035676 15084841 9696931 7567946 9292705 11342729
5	WT1	Wilms Tumor 1	Protein Coding	22.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	15084839 15754297 17721194 (more) 19967725 18929401 18724243 15084838 18317227 15628914
6	ESR1	Estrogen Receptor 1	Protein Coding	20.67	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	18931615 19446313 8958805 (more) 10023715 10835496 18317227 8625241 16575402 9329560 10786803 16648864
7	PGR	Progesterone Receptor	Protein Coding	18.82	Novoseek inferred ⁵⁵	9744308 14595509 18753970 (more) 19446313 8958805 10786803 16575402 10835496 16648864 14961567 10023715

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Variations for Female Reproductive Endometrioid Cancer

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Expression for Female Reproductive Endometrioid Cancer

Search GEO for disease gene expression data for Female Reproductive Endometrioid Cancer.

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Pathways for Female Reproductive Endometrioid Cancer

Pathways related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁷	12.45	CTNNB1 ESR1 PTEN TP53
2	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ Neurotrophin signaling pathway ³⁷ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.19	CTNNB1 ESR1 PTEN TP53
3	Proteoglycans in cancer ³⁷	11.94	CTNNB1 ESR1 TP53
4	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	11.69	CTNNB1 ESR1 PGR PTEN TP53
5	Thyroid hormone signaling pathway ³⁷	11.64	CTNNB1 ESR1 TP53
6	DNA Damage Response (only ATM dependent) ¹	11.6	CTNNB1 PTEN TP53
7	Glioblastoma Multiforme ⁶⁴	11.54	CTNNB1 PTEN TP53
8	Integrated Breast Cancer Pathway ¹	11.44	CTNNB1 ESR1 PTEN TP53
9	Copper homeostasis ¹	11.27	PTEN TP53
10	Integrated Cancer Pathway ¹	11.19	PTEN TP53
11	LKB1 signaling events ¹	11.13	ESR1 TP53
12	Signaling mediated by p38-alpha and p38-beta ¹	11.04	ESR1 TP53
13	Gastric Cancer Network 2 ¹	11	CTNNB1 TP53
14	Ovarian tumor domain proteases ⁶⁶	10.9	ESR1 PTEN TP53

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GO Terms for Female Reproductive Endometrioid Cancer

Cellular components related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	9.8	CTNNB1 ESR1 KRT7 PGR PTEN TP53
2	nucleus	GO:0005634	9.7	CTNNB1 ESR1 KRT7 PGR PTEN TP53
3	nucleoplasm	GO:0005654	9.43	CTNNB1 ESR1 PGR PTEN TP53 WT1
4	cytosol	GO:0005829	9.17	CTNNB1 ESR1 KRT7 PGR PTEN TP53

Biological processes related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

(show all 19)

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of transcription, DNA-templated	GO:0006355	9.88	CTNNB1 ESR1 PGR TP53 WT1
2	negative regulation of transcription by RNA polymerase II	GO:0000122	9.83	CTNNB1 ESR1 TP53 WT1
3	positive regulation of transcription, DNA-templated	GO:0045893	9.76	CTNNB1 ESR1 TP53 WT1
4	positive regulation of apoptotic process	GO:0043065	9.75	CTNNB1 PTEN TP53
5	regulation of apoptotic process	GO:0042981	9.73	CTNNB1 ESR1 TP53
6	protein deubiquitination	GO:0016579	9.72	ESR1 PTEN TP53
7	positive regulation of transcription by RNA polymerase II	GO:0045944	9.72	CTNNB1 ESR1 PGR TP53 WT1
8	negative regulation of gene expression	GO:0010629	9.71	CTNNB1 ESR1 PGR
9	negative regulation of apoptotic process	GO:0043066	9.71	CTNNB1 PTEN TP53 WT1
10	heart development	GO:0007507	9.69	CTNNB1 PTEN WT1
11	steroid hormone mediated signaling pathway	GO:0043401	9.58	ESR1 PGR
12	branching involved in ureteric bud morphogenesis	GO:0001658	9.57	CTNNB1 WT1
13	negative regulation of cell proliferation	GO:0008285	9.56	CTNNB1 PTEN TP53 WT1
14	positive regulation of pri-miRNA transcription by RNA polymerase II	GO:1902895	9.49	TP53 WT1
15	male genitalia development	GO:0030539	9.43	CTNNB1 WT1
16	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.37	ESR1 TP53
17	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.33	CTNNB1 ESR1 PTEN
18	positive regulation of gene expression	GO:0010628	9.26	CTNNB1 PTEN TP53 WT1
19	response to estradiol	GO:0032355	8.8	CTNNB1 ESR1 PTEN

Molecular functions related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.84	ESR1 PGR PTEN TP53
2	transcription factor binding	GO:0008134	9.7	CTNNB1 ESR1 TP53
3	proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	GO:0001077	9.63	ESR1 PGR WT1
4	zinc ion binding	GO:0008270	9.62	ESR1 PGR TP53 WT1
5	lipid binding	GO:0008289	9.61	ESR1 PGR PTEN
6	RNA polymerase II transcription factor binding	GO:0001085	9.51	CTNNB1 TP53
7	steroid hormone receptor activity	GO:0003707	9.49	ESR1 PGR
8	nuclear receptor activity	GO:0004879	9.48	ESR1 PGR
9	protein kinase binding	GO:0019901	9.46	CTNNB1 ESR1 PTEN TP53
10	estrogen receptor binding	GO:0030331	9.4	CTNNB1 ESR1
11	disordered domain specific binding	GO:0097718	9.37	CTNNB1 TP53
12	DNA-binding transcription factor activity	GO:0003700	9.35	CTNNB1 ESR1 PGR TP53 WT1
13	steroid binding	GO:0005496	9.26	ESR1 PGR
14	enzyme binding	GO:0019899	9.02	CTNNB1 ESR1 PGR PTEN TP53

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