MCID: FML005
MIFTS: 45

Female Reproductive Endometrioid Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Female Reproductive Endometrioid Cancer

MalaCards integrated aliases for Female Reproductive Endometrioid Cancer:

Name: Female Reproductive Endometrioid Cancer 12 15
Endometrioid Tumor 12 29 73
Female Reproductive Endometrioid Neoplasm 12
Carcinoma Endometrioid 55
Endometrioid Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3001
NCIt 50 C7113
UMLS 73 C0474809

Summaries for Female Reproductive Endometrioid Cancer

Disease Ontology : 12 A female reproductive organ cancer that is characterized by a resemblance to endometrium.

MalaCards based summary : Female Reproductive Endometrioid Cancer, also known as endometrioid tumor, is related to endometrial adenocarcinoma and adenocarcinoma. An important gene associated with Female Reproductive Endometrioid Cancer is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways are Pathways in cancer and Development HGF signaling pathway. Affiliated tissues include ovary, lung and brain, and related phenotypes are Decreased viability in esophageal squamous lineage and Decreased sensitivity to paclitaxel

Related Diseases for Female Reproductive Endometrioid Cancer

Diseases related to Female Reproductive Endometrioid Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 endometrial adenocarcinoma 30.9 CTNNB1 ESR1 KRT7 PGR PTEN TP53
2 adenocarcinoma 29.8 CTNNB1 PTEN TP53
3 ovarian cancer 1 29.6 KRT7 TP53 WT1
4 sertoli cell tumor 29.6 PGR WT1
5 endometriosis 29.5 ESR1 PGR PTEN
6 cervical adenocarcinoma 29.2 ESR1 KRT7 PGR TP53
7 endometrial cancer 28.8 CTNNB1 ESR1 KRT7 PGR PTEN TP53
8 endometrioid ovary carcinoma 11.3
9 fallopian tube endometrioid adenocarcinoma 11.1
10 mismatch repair cancer syndrome 10.2 CTNNB1 PTEN
11 cystitis cystica 10.2 CTNNB1 KRT7
12 supratentorial cancer 10.2 PTEN TP53
13 giant cell glioblastoma 10.2 PTEN TP53
14 cerebrum cancer 10.2 PTEN TP53
15 gliomatosis cerebri 10.2 PTEN TP53
16 biliary tract neoplasm 10.2 KRT7 TP53
17 endocervical adenocarcinoma 10.2 KRT7 TP53
18 ampulla of vater cancer 10.2 KRT7 TP53
19 appendix cancer 10.2 KRT7 TP53
20 vulva cancer 10.2 KRT7 TP53
21 necrotizing sialometaplasia 10.2 KRT7 TP53
22 eccrine sweat gland neoplasm 10.2 KRT7 TP53
23 sweat gland disease 10.2 KRT7 PGR
24 cystic teratoma 10.2 KRT7 TP53
25 dermoid cyst 10.2 KRT7 PGR
26 germ cell and embryonal cancer 10.2 KRT7 TP53
27 inverted papilloma 10.2 KRT7 TP53
28 pseudomyxoma peritonei 10.2 KRT7 TP53
29 pancreatic ductal carcinoma 10.2 KRT7 TP53
30 lung benign neoplasm 10.2 KRT7 TP53
31 ovary adenocarcinoma 10.2 KRT7 TP53
32 spindle cell carcinoma 10.2 KRT7 PGR
33 adenosquamous carcinoma 10.2 KRT7 TP53
34 bile duct adenocarcinoma 10.2 KRT7 TP53
35 epithelial-myoepithelial carcinoma 10.2 KRT7 TP53
36 breast secretory carcinoma 10.2 KRT7 PGR
37 basaloid squamous cell carcinoma 10.2 KRT7 TP53
38 oropharynx cancer 10.2 KRT7 TP53
39 tonsil cancer 10.2 KRT7 TP53
40 pancreatic mucinous cystadenoma 10.2 KRT7 PGR
41 granulosa cell tumor of the ovary 10.2 KRT7 TP53
42 breast duct papilloma 10.1 PGR PTEN
43 cervical squamous cell carcinoma 10.1 CTNNB1 TP53
44 pharynx cancer 10.1 CTNNB1 TP53
45 tongue disease 10.1 CTNNB1 TP53
46 atypical teratoid rhabdoid tumor 10.1 CTNNB1 TP53
47 cervix disease 10.1 CTNNB1 TP53
48 large intestine adenocarcinoma 10.1 CTNNB1 KRT7
49 intestinal benign neoplasm 10.1 CTNNB1 TP53
50 lung acinar adenocarcinoma 10.1 CTNNB1 KRT7

Graphical network of the top 20 diseases related to Female Reproductive Endometrioid Cancer:



Diseases related to Female Reproductive Endometrioid Cancer

Symptoms & Phenotypes for Female Reproductive Endometrioid Cancer

GenomeRNAi Phenotypes related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.43 CTNNB1 ESR1 KRT7 PGR PTEN TP53
2 Decreased sensitivity to paclitaxel GR00112-A-0 9.16 PTEN WT1
3 Increased cell death HMECs cells GR00103-A-0 8.92 CTNNB1 PGR PTEN TP53

MGI Mouse Phenotypes related to Female Reproductive Endometrioid Cancer:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 CTNNB1 ESR1 KRT7 PGR PTEN TP53
2 homeostasis/metabolism MP:0005376 10.07 CTNNB1 ESR1 KRT7 PGR PTEN TP53
3 cardiovascular system MP:0005385 10.05 CTNNB1 ESR1 PGR PTEN TP53 WT1
4 embryo MP:0005380 10.03 CTNNB1 ESR1 PGR PTEN TP53 WT1
5 endocrine/exocrine gland MP:0005379 10.02 CTNNB1 ESR1 PGR PTEN TP53 WT1
6 hematopoietic system MP:0005397 10.01 CTNNB1 ESR1 PGR PTEN TP53 WT1
7 immune system MP:0005387 9.99 CTNNB1 ESR1 PGR PTEN TP53 WT1
8 muscle MP:0005369 9.91 CTNNB1 ESR1 PGR PTEN TP53 WT1
9 integument MP:0010771 9.89 CTNNB1 ESR1 PGR PTEN TP53
10 limbs/digits/tail MP:0005371 9.88 CTNNB1 ESR1 PGR PTEN TP53
11 neoplasm MP:0002006 9.88 CTNNB1 ESR1 PGR PTEN TP53 WT1
12 liver/biliary system MP:0005370 9.85 CTNNB1 ESR1 PTEN TP53 WT1
13 normal MP:0002873 9.8 CTNNB1 ESR1 PGR PTEN TP53 WT1
14 no phenotypic analysis MP:0003012 9.77 CTNNB1 ESR1 PGR TP53 WT1
15 renal/urinary system MP:0005367 9.73 CTNNB1 ESR1 KRT7 PTEN TP53 WT1
16 reproductive system MP:0005389 9.63 CTNNB1 ESR1 PGR PTEN TP53 WT1
17 respiratory system MP:0005388 9.35 CTNNB1 ESR1 PTEN TP53 WT1
18 skeleton MP:0005390 9.02 CTNNB1 ESR1 PGR PTEN TP53

Drugs & Therapeutics for Female Reproductive Endometrioid Cancer

Search Clinical Trials , NIH Clinical Center for Female Reproductive Endometrioid Cancer

Genetic Tests for Female Reproductive Endometrioid Cancer

Genetic tests related to Female Reproductive Endometrioid Cancer:

# Genetic test Affiliating Genes
1 Endometrioid Tumor 29

Anatomical Context for Female Reproductive Endometrioid Cancer

MalaCards organs/tissues related to Female Reproductive Endometrioid Cancer:

41
Ovary, Lung, Brain, Bone, Tongue, Prostate, Cervix

Publications for Female Reproductive Endometrioid Cancer

Articles related to Female Reproductive Endometrioid Cancer:

# Title Authors Year
1
Atypical proliferative endometrioid tumor of ovary: Report of a rare case. ( 26497398 )
2016
2
Sertoliform Endometrioid Tumor of Ovary Presenting as Torsion. ( 27365921 )
2016
3
Prediction of staging with preoperative parameters and frozen/section in patients with a preoperative diagnosis of grade 1 endometrioid tumor in endometrial cancer. ( 24790516 )
2014
4
Borderline endometrioid tumor arising in a paratubal cyst: a case report. ( 15790473 )
2005
5
Morules with optically clear nuclei in ovarian borderline endometrioid tumor. ( 12588418 )
2002
6
Androgen-producing, atypically proliferating endometrioid tumor arising in endometriosis. ( 11332919 )
2001
7
Endometrioid tumor of the ovary with mucinous and serous components. ( 4652772 )
1972

Variations for Female Reproductive Endometrioid Cancer

Expression for Female Reproductive Endometrioid Cancer

Search GEO for disease gene expression data for Female Reproductive Endometrioid Cancer.

Pathways for Female Reproductive Endometrioid Cancer

GO Terms for Female Reproductive Endometrioid Cancer

Cellular components related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.8 CTNNB1 ESR1 KRT7 PGR PTEN TP53
2 nucleus GO:0005634 9.7 CTNNB1 ESR1 KRT7 PGR PTEN TP53
3 nucleoplasm GO:0005654 9.43 CTNNB1 ESR1 PGR PTEN TP53 WT1
4 cytosol GO:0005829 9.17 CTNNB1 ESR1 KRT7 PGR PTEN TP53

Biological processes related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.88 CTNNB1 ESR1 PGR TP53 WT1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.83 CTNNB1 ESR1 TP53 WT1
3 positive regulation of transcription, DNA-templated GO:0045893 9.76 CTNNB1 ESR1 TP53 WT1
4 positive regulation of apoptotic process GO:0043065 9.75 CTNNB1 PTEN TP53
5 regulation of apoptotic process GO:0042981 9.73 CTNNB1 ESR1 TP53
6 protein deubiquitination GO:0016579 9.72 ESR1 PTEN TP53
7 positive regulation of transcription by RNA polymerase II GO:0045944 9.72 CTNNB1 ESR1 PGR TP53 WT1
8 negative regulation of gene expression GO:0010629 9.71 CTNNB1 ESR1 PGR
9 negative regulation of apoptotic process GO:0043066 9.71 CTNNB1 PTEN TP53 WT1
10 heart development GO:0007507 9.69 CTNNB1 PTEN WT1
11 steroid hormone mediated signaling pathway GO:0043401 9.58 ESR1 PGR
12 branching involved in ureteric bud morphogenesis GO:0001658 9.57 CTNNB1 WT1
13 negative regulation of cell proliferation GO:0008285 9.56 CTNNB1 PTEN TP53 WT1
14 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.49 TP53 WT1
15 male genitalia development GO:0030539 9.43 CTNNB1 WT1
16 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.37 ESR1 TP53
17 positive regulation of DNA-binding transcription factor activity GO:0051091 9.33 CTNNB1 ESR1 PTEN
18 positive regulation of gene expression GO:0010628 9.26 CTNNB1 PTEN TP53 WT1
19 response to estradiol GO:0032355 8.8 CTNNB1 ESR1 PTEN

Molecular functions related to Female Reproductive Endometrioid Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.84 ESR1 PGR PTEN TP53
2 transcription factor binding GO:0008134 9.7 CTNNB1 ESR1 TP53
3 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.63 ESR1 PGR WT1
4 zinc ion binding GO:0008270 9.62 ESR1 PGR TP53 WT1
5 lipid binding GO:0008289 9.61 ESR1 PGR PTEN
6 RNA polymerase II transcription factor binding GO:0001085 9.51 CTNNB1 TP53
7 steroid hormone receptor activity GO:0003707 9.49 ESR1 PGR
8 nuclear receptor activity GO:0004879 9.48 ESR1 PGR
9 protein kinase binding GO:0019901 9.46 CTNNB1 ESR1 PTEN TP53
10 estrogen receptor binding GO:0030331 9.4 CTNNB1 ESR1
11 disordered domain specific binding GO:0097718 9.37 CTNNB1 TP53
12 DNA-binding transcription factor activity GO:0003700 9.35 CTNNB1 ESR1 PGR TP53 WT1
13 steroid binding GO:0005496 9.26 ESR1 PGR
14 enzyme binding GO:0019899 9.02 CTNNB1 ESR1 PGR PTEN TP53

Sources for Female Reproductive Endometrioid Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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