MCID: FML038
MIFTS: 42

Female Reproductive Organ Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Female Reproductive Organ Cancer

MalaCards integrated aliases for Female Reproductive Organ Cancer:

Name: Female Reproductive Organ Cancer 12 15
Malignant Female Reproductive System Neoplasm 73
Malignant Neoplasm of Female Genital Organ 12
Malignant Gynecologic Tumor 12
Female Reproductive Cancer 12
Genital Neoplasms, Female 44

Classifications:



External Ids:

Disease Ontology 12 DOID:120
ICD10 33 C57 C57.7
ICD9CM 35 184
MeSH 44 D005833
NCIt 50 C3053 C4913
SNOMED-CT 68 126907002 188207007

Summaries for Female Reproductive Organ Cancer

Disease Ontology : 12 A reproductive organ cancer that is manifested in the female genitals. This includes organs such as the ovaries, fallopian tubes, uterus, cervix, vagina and vulva.

MalaCards based summary : Female Reproductive Organ Cancer, also known as malignant female reproductive system neoplasm, is related to cervical cancer and fallopian tube carcinoma. An important gene associated with Female Reproductive Organ Cancer is BRCA1 (BRCA1, DNA Repair Associated), and among its related pathways/superpathways are Gene Expression and ERK Signaling. Affiliated tissues include cervix, uterus and ovary, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Female Reproductive Organ Cancer

Diseases related to Female Reproductive Organ Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 cervical cancer 32.9 AKT1 CDKN2A ERBB2 PTEN TLR9 TP53
2 fallopian tube carcinoma 32.8 BRCA1 BRCA2 ERBB2 ESR1 PGR TP53
3 cervical adenocarcinoma 32.3 CDKN2A ERBB2 ESR1 TP53
4 ovarian cancer 32.1 AKT1 BRCA1 BRCA2 ERBB2 ESR1 MLH1
5 hereditary site-specific ovarian cancer syndrome 11.3 BRCA1 BRCA2
6 nosophobia 11.3 BRCA1 BRCA2 PGR
7 cancerophobia 11.3 BRCA1 BRCA2 PGR
8 tuberculous salpingitis 11.3 BRCA1 BRCA2 ERBB2
9 endometrium carcinoma in situ 11.3 PGR TP53
10 scirrhous adenocarcinoma 11.3 ERBB2 PGR
11 breast duct papilloma 11.3 PGR PTEN
12 breast apocrine carcinoma 11.3 ERBB2 PGR
13 vestibular gland benign neoplasm 11.3 ESR1 PGR TP53
14 bartholin's gland adenoma 11.3 ESR1 PGR TP53
15 peritoneum cancer 11.3 BRCA1 BRCA2 TUBB3
16 papillary serous adenocarcinoma 11.2 BRCA1 PGR TP53
17 glassy cell carcinoma of the cervix 11.2 ERBB2 ESR1 PGR
18 vulvar syringoma 11.2 ESR1 PGR
19 lung leiomyoma 11.2 ESR1 PGR
20 endometrial clear cell adenocarcinoma 11.2 ESR1 TP53
21 female reproductive endometrioid cancer 11.2 PGR PTEN TP53
22 breast reconstruction 11.2 BRCA1 BRCA2
23 brain stem astrocytic neoplasm 11.2 CDKN2A TP53
24 breast scirrhous carcinoma 11.2 ERBB2 ESR1 PGR
25 uterine body mixed cancer 11.2 ERBB2 PGR TP53
26 breast papillomatosis 11.2 CDKN2A ERBB2
27 mutagen sensitivity 11.2 BRCA1 BRCA2 TP53
28 breast squamous cell carcinoma 11.2 ERBB2 PGR TP53
29 progesterone-receptor positive breast cancer 11.2 ERBB2 ESR1 PGR
30 early invasive cervical adenocarcinoma 11.2 CDKN2A INSM1
31 microinvasive cervical squamous cell carcinoma 11.2 INSM1 PTPRN
32 oncocytic breast carcinoma 11.2 ERBB2 ESR1 PGR
33 microglandular adenosis 11.2 ERBB2 PGR TP53
34 apocrine adenocarcinoma 11.2 ERBB2 ESR1 PGR
35 endocervical carcinoma 11.2 CDKN2A ESR1 MAPK8IP1
36 uterine corpus serous adenocarcinoma 11.2 BRCA1 BRCA2 ERBB2 TP53
37 breast adenoid cystic carcinoma 11.2 ERBB2 ESR1 PGR
38 rare adenocarcinoma of the breast 11.2 AKT1 TP53
39 lobular neoplasia 11.2 BRCA1 ERBB2 ESR1
40 adenosarcoma 11.2 ESR1 PGR TP53
41 endometrial squamous cell carcinoma 11.2 CDKN2A ESR1 PGR
42 lynch syndrome i 11.2 BRCA1 BRCA2 MLH1
43 oral leukoplakia 11.2 CDKN2A ERBB2 TP53
44 endometrial mucinous adenocarcinoma 11.2 CDKN2A ESR1 PGR
45 luminal breast carcinoma 11.2 ERBB2 ESR1 PGR
46 adenoid basal cell carcinoma 11.2 CDKN2A ESR1 PGR
47 breast giant fibroadenoma 11.2 BRCA2 CDKN2A ESR1
48 inflammatory breast carcinoma 11.2 ERBB2 ESR1 PGR
49 vulvar benign neoplasm 11.2 ESR1 PGR
50 hidradenocarcinoma 11.2 ERBB2 ESR1 TP53

Graphical network of the top 20 diseases related to Female Reproductive Organ Cancer:



Diseases related to Female Reproductive Organ Cancer

Symptoms & Phenotypes for Female Reproductive Organ Cancer

GenomeRNAi Phenotypes related to Female Reproductive Organ Cancer according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 10.28 MAPK8IP1
2 Decreased viability GR00221-A-1 10.28 CDKN2A AKT1 ESR1
3 Decreased viability GR00221-A-2 10.28 AKT1 ESR1
4 Decreased viability GR00221-A-3 10.28 CDKN2A ERBB2 AKT1
5 Decreased viability GR00221-A-4 10.28 MAPK8IP1 CDKN2A ERBB2 AKT1 ESR1
6 Decreased viability GR00301-A 10.28 MAPK8IP1
7 Decreased viability GR00342-S-3 10.28 MAPK8IP1
8 Decreased viability GR00402-S-2 10.28 CDKN2A ERBB2 AKT1 ESR1 MAPK8IP1
9 Decreased viability in esophageal squamous lineage GR00235-A 9.9 PTEN TP53 TUBB3 BRCA2 MLH1 CDKN2A
10 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.83 PTEN TP53 BRCA2 MLH1 CDKN2A AKT1
11 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.83 PTEN TP53 BRCA2 MLH1 CDKN2A AKT1
12 Increased cell death HMECs cells GR00103-A-0 9.43 PTEN PTPRN TP53 PGR AREG BRCA1

MGI Mouse Phenotypes related to Female Reproductive Organ Cancer:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.49 VEGFA ERBB2 CDKN2A ESR1 MAPK8IP2 GP5
2 cellular MP:0005384 10.47 TUBB3 VEGFA ESR1 ERBB2 CDKN2A MAPK8IP1
3 endocrine/exocrine gland MP:0005379 10.47 VEGFA ERBB2 CDKN2A ESR1 MAPK8IP2 MLH1
4 mortality/aging MP:0010768 10.39 TUBB3 VEGFA ERBB2 CDKN2A ESR1 MAPK8IP1
5 behavior/neurological MP:0005386 10.38 VEGFA TP53 BRCA2 ERBB2 CDKN2A MAPK8IP1
6 growth/size/body region MP:0005378 10.37 VEGFA TP53 BRCA2 ERBB2 CDKN2A MAPK8IP1
7 digestive/alimentary MP:0005381 10.36 VEGFA ERBB2 CDKN2A ESR1 MLH1 INSM1
8 cardiovascular system MP:0005385 10.3 VEGFA TP53 CDKN2A ERBB2 ESR1 BRCA1
9 immune system MP:0005387 10.3 VEGFA TP53 BRCA2 CDKN2A ESR1 PTPRN
10 hematopoietic system MP:0005397 10.29 TP53 VEGFA CDKN2A BRCA2 ESR1 BRCA1
11 integument MP:0010771 10.29 VEGFA BRCA2 ERBB2 CDKN2A ESR1 MLH1
12 embryo MP:0005380 10.27 VEGFA BRCA2 ERBB2 CDKN2A ESR1 PTEN
13 nervous system MP:0003631 10.18 TUBB3 VEGFA BRCA2 ERBB2 CDKN2A ESR1
14 neoplasm MP:0002006 10.14 VEGFA ERBB2 CDKN2A ESR1 MLH1 PGR
15 limbs/digits/tail MP:0005371 10.1 VEGFA BRCA2 ERBB2 ESR1 PTEN TP53
16 muscle MP:0005369 10.09 VEGFA ERBB2 CDKN2A ESR1 PGR AKT1
17 liver/biliary system MP:0005370 10.02 VEGFA TP53 CDKN2A MAPK8IP1 ESR1 AKT1
18 reproductive system MP:0005389 10 VEGFA ERBB2 CDKN2A ESR1 MAPK8IP1 MAPK8IP2
19 normal MP:0002873 9.96 VEGFA TP53 BRCA2 ERBB2 ESR1 GP5
20 no phenotypic analysis MP:0003012 9.92 TP53 VEGFA CDKN2A ESR1 MAPK8IP2 ESS2
21 respiratory system MP:0005388 9.7 TUBB3 VEGFA ERBB2 CDKN2A ESR1 MLH1
22 skeleton MP:0005390 9.32 VEGFA TP53 BRCA2 ERBB2 CDKN2A ESR1

Drugs & Therapeutics for Female Reproductive Organ Cancer

Search Clinical Trials , NIH Clinical Center for Female Reproductive Organ Cancer

Cochrane evidence based reviews: genital neoplasms, female

Genetic Tests for Female Reproductive Organ Cancer

Anatomical Context for Female Reproductive Organ Cancer

MalaCards organs/tissues related to Female Reproductive Organ Cancer:

41
Cervix, Uterus, Ovary

Publications for Female Reproductive Organ Cancer

Articles related to Female Reproductive Organ Cancer:

# Title Authors Year
1
Statin use and female reproductive organ cancer risk in a large population-based setting. ( 19043788 )
2009

Variations for Female Reproductive Organ Cancer

Expression for Female Reproductive Organ Cancer

Search GEO for disease gene expression data for Female Reproductive Organ Cancer.

Pathways for Female Reproductive Organ Cancer

Pathways related to Female Reproductive Organ Cancer according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 AKT1 BRCA1 CDKN2A ERBB2 ESR1 MLH1
2
Show member pathways
13.8 AKT1 AREG BRCA1 CDKN2A ERBB2 ESR1
3
Show member pathways
13.69 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
4
Show member pathways
13.48 AKT1 AREG BRCA1 ERBB2 MAPK8IP1 MAPK8IP2
5
Show member pathways
13.38 AKT1 AREG ERBB2 MAPK8IP1 MAPK8IP2 PTEN
6
Show member pathways
12.95 AKT1 AREG BRCA1 ERBB2 PTEN TP53
7
Show member pathways
12.94 AKT1 BRCA1 CDKN2A MLH1 PTEN TP53
8
Show member pathways
12.77 AKT1 AREG BRCA2 CDKN2A ERBB2 MLH1
9
Show member pathways
12.7 AKT1 ERBB2 ESR1 PTEN TP53
10 12.7 AKT1 BRCA2 CDKN2A ERBB2 ESR1 MLH1
11 12.67 AKT1 AREG ERBB2 MAPK8IP1 MAPK8IP2 TP53
12
Show member pathways
12.58 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
13 12.48 BRCA1 BRCA2 CDKN2A MLH1 TP53
14 12.46 BRCA1 CDKN2A ERBB2 PTEN TP53 VEGFA
15
Show member pathways
12.44 AKT1 AREG ERBB2 TP53 VEGFA
16
Show member pathways
12.37 AKT1 BRCA1 ESR1 VEGFA
17
Show member pathways
12.35 BRCA1 CDKN2A PTEN TP53
18 12.27 AKT1 ERBB2 ESR1 TP53 VEGFA
19
Show member pathways
12.24 AKT1 BRCA1 PTEN TP53
20
Show member pathways
12.21 AKT1 AREG PTEN VEGFA
21
Show member pathways
12.19 BRCA1 CDKN2A ESR1 PGR
22 12.14 AKT1 CDKN2A PTEN TP53
23 12.14 AKT1 MLH1 TLR9 TP53 VEGFA
24 12.13 AKT1 ERBB2 PTEN TP53
25
Show member pathways
12 AKT1 ERBB2 TLR9 TP53
26
Show member pathways
11.99 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
27 11.93 AKT1 CDKN2A PTEN TP53
28 11.89 AKT1 CDKN2A ERBB2 PTEN TP53
29 11.89 AKT1 BRCA1 BRCA2 ESR1 PTEN TP53
30 11.83 AKT1 BRCA1 PTEN
31 11.79 AKT1 PTEN TP53
32
Show member pathways
11.78 BRCA1 BRCA2 TP53
33
Show member pathways
11.72 AKT1 CDKN2A TP53
34 11.71 CDKN2A ERBB2 TP53 VEGFA
35 11.65 AKT1 ERBB2 PTEN TP53
36 11.62 AKT1 BRCA1 ERBB2 PTEN TP53
37 11.56 AKT1 PTEN TP53
38 11.56 CDKN2A TP53 VEGFA
39 11.5 AKT1 BRCA1 TP53 VEGFA
40 11.44 AKT1 BRCA1 PTEN TP53
41 11.36 ESR1 PTEN TP53
42 11.3 AKT1 BRCA1 CDKN2A ERBB2 MLH1 TP53
43 11.26 AKT1 BRCA1 TP53

GO Terms for Female Reproductive Organ Cancer

Cellular components related to Female Reproductive Organ Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.53 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
2 protein-containing complex GO:0032991 9.43 AKT1 BRCA1 BRCA2 ESR1 MAPK8IP2 TP53
3 cytoplasm GO:0005737 10.03 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2

Biological processes related to Female Reproductive Organ Cancer according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.99 AKT1 BRCA1 BRCA2 MLH1 TP53
2 negative regulation of apoptotic process GO:0043066 9.93 AKT1 ERBB2 MAPK8IP1 PTEN TP53 VEGFA
3 nervous system development GO:0007399 9.91 AKT1 ERBB2 ESS2 INSM1 PTEN VEGFA
4 negative regulation of gene expression GO:0010629 9.9 AKT1 ESR1 PGR VEGFA
5 cell proliferation GO:0008283 9.8 AKT1 AREG BRCA2 ERBB2 PTEN TP53
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.79 AREG TP53 VEGFA
7 response to estrogen GO:0043627 9.76 BRCA1 ESR1 PTPRN
8 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.73 BRCA1 BRCA2 MLH1
9 cellular response to hypoxia GO:0071456 9.71 AKT1 PTEN TP53 VEGFA
10 replicative senescence GO:0090399 9.62 CDKN2A TP53
11 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.61 ESR1 TP53
12 negative regulation of cell size GO:0045792 9.61 AKT1 PTEN
13 positive regulation of transcription by RNA polymerase II GO:0045944 9.61 AKT1 BRCA1 CDKN2A ESR1 PGR PTPRN
14 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.58 CDKN2A PTEN
15 negative regulation of immature T cell proliferation in thymus GO:0033088 9.54 CDKN2A ERBB2
16 positive regulation of cell cycle arrest GO:0071158 9.54 BRCA1 INSM1 TP53
17 chordate embryonic development GO:0043009 9.51 BRCA1 BRCA2
18 cellular response to decreased oxygen levels GO:0036294 9.49 AKT1 PTEN
19 epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 9.48 AREG ESR1
20 mammary gland alveolus development GO:0060749 9.43 AREG ESR1 VEGFA
21 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.33 BRCA1 BRCA2 TP53
22 positive regulation of gene expression GO:0010628 9.23 AKT1 BRCA1 CDKN2A ERBB2 PTEN TLR9
23 regulation of transcription, DNA-templated GO:0006355 10.27 BRCA1 BRCA2 CDKN2A ERBB2 ESR1 INSM1
24 positive regulation of cell proliferation GO:0008284 10.03 AKT1 AREG INSM1 PTEN VEGFA
25 cell cycle GO:0007049 10.02 BRCA1 BRCA2 CDKN2A INSM1 MLH1 TP53
26 positive regulation of transcription, DNA-templated GO:0045893 10 AKT1 BRCA1 BRCA2 CDKN2A ESR1 TP53

Molecular functions related to Female Reproductive Organ Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.86 AKT1 BRCA2 ERBB2 ESR1 PGR PTEN
2 enzyme binding GO:0019899 9.43 AKT1 BRCA1 ESR1 PGR PTEN TP53
3 MAP-kinase scaffold activity GO:0005078 9.37 MAPK8IP1 MAPK8IP2
4 nitric-oxide synthase regulator activity GO:0030235 9.32 AKT1 ESR1
5 protein kinase binding GO:0019901 9.17 AKT1 CDKN2A ESR1 MAPK8IP1 MAPK8IP2 PTEN
6 protein binding GO:0005515 10.13 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2

Sources for Female Reproductive Organ Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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