Female Reproductive System Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: FML039 MIFTS: 39	Female Reproductive System Disease Categories: Reproductive diseases
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Aliases & Classifications for Female Reproductive System Disease

MalaCards integrated aliases for Female Reproductive System Disease:

Name: Female Reproductive System Disease ¹² ¹⁵

Female Reproductive System Disorder ⁷³

Genital Diseases, Female ⁴⁴

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:229

ICD9CM ³⁵ 629.9

MeSH ⁴⁴ D005831

SNOMED-CT ⁶⁸ 156032001 156066005 198486002 more

UMLS ⁷³ C0017411 C0236100

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Summaries for Female Reproductive System Disease

Disease Ontology : ¹² A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes.

MalaCards based summary : Female Reproductive System Disease, also known as female reproductive system disorder, is related to preterm premature rupture of the membranes and endometriosis, and has symptoms including leukorrhea, mastodynia and genital itching. An important gene associated with Female Reproductive System Disease is AMH (Anti-Mullerian Hormone), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Hormones and insulin have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and ovary, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

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Related Diseases for Female Reproductive System Disease

Diseases related to Female Reproductive System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)

#	Related Disease	Score	Top Affiliating Genes
1	preterm premature rupture of the membranes	32.7	CXCL8 IL6 SERPINH1
2	endometriosis	32.2	CXCL8 CYP19A1 GNRH1 IL6 PGR
3	uterine anomalies	31.8	CXCL8 CYP19A1 IL6 OXT SERPINH1 TLR9
4	pituitary infarct	11.1	GNRH1 PRL
5	endometriosis of uterus	11.0	GNRH1 PRL
6	precocious puberty, male-limited	11.0	CYP19A1 FSHR
7	intracystic papillary adenoma	11.0	PGR PRL
8	mccune-albright syndrome	11.0	AMH CYP19A1 PRL
9	oocyte maturation defect 1	11.0	BMP15 CYP19A1
10	endometriosis of ovary	11.0	AMH CYP19A1 PGR
11	mammographic density	11.0	CYP19A1 PGR PRL
12	hypogonadotropism	11.0	GNRH1 PRL
13	hypogonadotropic hypogonadism 23 without anosmia	11.0	FSHR GNRH1
14	recurrent corneal erosion	11.0	CXCL8 IL6
15	hypoactive sexual desire disorder	11.0	CYP19A1 SHBG
16	bagassosis	10.9	CXCL8 IL6
17	androgenic alopecia	10.9	CYP19A1 PRL SHBG
18	ectopic pregnancy	10.9
19	hyperprolactinemia	10.9	GNRH1 PRL SHBG
20	juvenile nasopharyngeal angiofibroma	10.9	CYP19A1 PGR TLR9
21	funisitis	10.9	CXCL8 IL6 SERPINH1
22	vaginal disease	10.9	CXCL8 IL6 SERPINH1
23	cervical incompetence	10.9	IL6 SERPINH1
24	ovarian cyst	10.9	FOXL2 NOBOX PRL
25	vaginitis	10.9	CXCL8 IL6 SERPINH1
26	ovarian hyperstimulation syndrome	10.9	AMH CYP19A1 FSHR GNRH1
27	nasal cavity disease	10.9	CXCL8 TLR9 TRPV1
28	eye lymphoma	10.9	IL6 TLR9
29	nose disease	10.9	CXCL8 TLR9 TRPV1
30	hypothalamic disease	10.9	GNRH1 PRL
31	pulpitis	10.9	CXCL8 IL6 TRPV1
32	upper respiratory tract disease	10.9	CXCL8 TLR9 TRPV1
33	interstitial cystitis	10.8	CXCL8 IL6 TRPV1
34	chiasmal syndrome	10.8	GNRH1 PRL
35	hypersensitivity reaction disease	10.8	IL6 TLR9 TRPV1
36	leiomyoma	10.8	CYP19A1 GNRH1 PGR
37	progesterone-receptor positive breast cancer	10.8	CYP19A1 PGR
38	esophagitis	10.8	CXCL8 IL6 TRPV1
39	breast disease	10.8	PGR PRL SHBG
40	varicocele	10.8	AMH GNRH1 PRL SHBG
41	cystitis	10.8	CXCL8 IL6 TRPV1
42	mouth disease	10.8	IL6 TLR9 TRPV1
43	cryptorchidism, unilateral or bilateral	10.8	AMH CYP19A1 GNRH1 SHBG
44	androgen insensitivity, partial	10.8	CYP19A1 SHBG
45	sexual disorder	10.8	OXT PRL SHBG
46	hyperandrogenism	10.8	CYP19A1 GNRH1 PRL SHBG
47	glucose metabolism disease	10.8	IL6 TLR9 TRPV1
48	acute transverse myelitis	10.8	CXCL8 IL6
49	urinary system disease	10.8	IL6 TLR9 TRPV1
50	gonadal disease	10.8	AMH FSHR GNRH1 SHBG

Graphical network of the top 20 diseases related to Female Reproductive System Disease:

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Symptoms & Phenotypes for Female Reproductive System Disease

UMLS symptoms related to Female Reproductive System Disease:

leukorrhea, mastodynia, genital itching, pruritus vulvae, vaginal pruritus, breast engorgement, nipple discharge, menometrorrhagia, perineal pain female, genitalia external painful, vaginal odor, menopausal symptoms, vaginal discomfort, vaginal pain, burning feeling vagina, mastoscirrhus, discomfort of vulva

MGI Mouse Phenotypes related to Female Reproductive System Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	10.2	AREG IL6 BMP15 CYP19A1 NOBOX OXT
2	homeostasis/metabolism	MP:0005376	10.07	GNRH1 AREG IL6 CYP19A1 OXT FOXL2
3	digestive/alimentary	MP:0005381	9.91	GNRH1 AREG IL6 CYP19A1 OXT TLR9
4	integument	MP:0010771	9.85	AREG IL6 CYP19A1 OXT FMR1 PGR
5	neoplasm	MP:0002006	9.5	GNRH1 IL6 PGR FSHR AMH TRPV1
6	reproductive system	MP:0005389	9.5	IL6 BMP15 CYP19A1 NOBOX OXT FMR1

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Drugs & Therapeutics for Female Reproductive System Disease

Drugs for Female Reproductive System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Hormones		Not Applicable
2	insulin		Not Applicable
3	Insulin, Globin Zinc		Not Applicable

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Effect of Modifications of Nutritional Intake Upon Reproductive Hormones in Normal Women	Completed	NCT02233283	Not Applicable

Search NIH Clinical Center for Female Reproductive System Disease

Cochrane evidence based reviews: genital diseases, female

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Genetic Tests for Female Reproductive System Disease

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Anatomical Context for Female Reproductive System Disease

MalaCards organs/tissues related to Female Reproductive System Disease:

⁴¹

Cervix, Uterus, Ovary

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Publications for Female Reproductive System Disease

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Genes for Female Reproductive System Disease

Genes related to Female Reproductive System Disease (0 elite genes):

(show all 32)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AMH	Anti-Mullerian Hormone	Protein Coding	18.86	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	18.62	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	SERPINH1	Serpin Family H Member 1	Protein Coding	18.53	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	17.63	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	PRL	Prolactin	Protein Coding	17.61	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	GDF9	Growth Differentiation Factor 9	Protein Coding	17.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	17.56	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	FMR1	Fragile X Mental Retardation 1	Protein Coding	17.55	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	FSHR	Follicle Stimulating Hormone Receptor	Protein Coding	17.53	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	BMP15	Bone Morphogenetic Protein 15	Protein Coding	17.52	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	FOXL2	Forkhead Box L2	Protein Coding	17.5	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	PGR	Progesterone Receptor	Protein Coding	17.43	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	TLR9	Toll Like Receptor 9	Protein Coding	17.4	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	17.31	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	IL6	Interleukin 6	Protein Coding	17.3	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	SHBG	Sex Hormone Binding Globulin	Protein Coding	17.28	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
17	NOBOX	NOBOX Oogenesis Homeobox	Protein Coding	17.16	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
18	ZP3	Zona Pellucida Glycoprotein 3	Protein Coding	17.15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
19	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	7.77	DISEASES inferred ¹⁵
20	AREG	Amphiregulin	Protein Coding	7.64	DISEASES inferred ¹⁵ ¹⁵
21	IL1B	Interleukin 1 Beta	Protein Coding	7.11	DISEASES inferred ¹⁵
22	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	6.97	DISEASES inferred ¹⁵
23	TNF	Tumor Necrosis Factor	Protein Coding	6.9	DISEASES inferred ¹⁵
24	ESR2	Estrogen Receptor 2	Protein Coding	6.86	DISEASES inferred ¹⁵
25	NR5A1	Nuclear Receptor Subfamily 5 Group A Member 1	Protein Coding	6.85	DISEASES inferred ¹⁵
26	HOXA10	Homeobox A10	Protein Coding	6.85	DISEASES inferred ¹⁵
27	ESR1	Estrogen Receptor 1	Protein Coding	6.81	DISEASES inferred ¹⁵
28	INS	Insulin	Protein Coding	6.77	DISEASES inferred ¹⁵
29	POMC	Proopiomelanocortin	Protein Coding	6.68	DISEASES inferred ¹⁵
30	CYP17A1	Cytochrome P450 Family 17 Subfamily A Member 1	Protein Coding	6.53	DISEASES inferred ¹⁵
31	CSH1	Chorionic Somatomammotropin Hormone 1	Protein Coding	6.47	DISEASES inferred ¹⁵
32	CSH2	Chorionic Somatomammotropin Hormone 2	Protein Coding	6.47	DISEASES inferred ¹⁵

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Variations for Female Reproductive System Disease

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Expression for Female Reproductive System Disease

Search GEO for disease gene expression data for Female Reproductive System Disease.

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Pathways for Female Reproductive System Disease

Pathways related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.26	AREG BMP15 CXCL8 GDF9 GNRH1 IL6
2	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.15	AREG BMP15 CXCL8 GDF9 GNRH1 IL6
3	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.38	AREG GDF9 GNRH1 IL6 TLR9
4	Glucocorticoid receptor regulatory network ¹	11.49	CXCL8 IL6 PRL
5	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.45	AREG BMP15 CXCL8 GDF9 GNRH1 IL6
6	Malaria ³⁷	11.19	CXCL8 IL6 TLR9
7	Ovarian steroidogenesis ³⁷	11.12	BMP15 CYP19A1 FSHR
8	Follicle Stimulating Hormone (FSH) signaling pathway ¹	10.76	AREG CYP19A1 FSHR
9	Hormone ligand-binding receptors ⁶⁶	10.55	FSHR GNRH1
10	Ovarian Infertility Genes ¹	10.53	CYP19A1 FSHR GDF9 PGR ZP3

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GO Terms for Female Reproductive System Disease

Cellular components related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.7	AMH BMP15 CXCL8 GDF9 GNRH1 IL6
2	extracellular space	GO:0005615	9.4	AMH AREG BMP15 CXCL8 GDF9 GNRH1

Biological processes related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	BMP signaling pathway	GO:0030509	9.73	AMH BMP15 GDF9
2	response to organic cyclic compound	GO:0014070	9.73	AMH AREG GNRH1 OXT
3	female pregnancy	GO:0007565	9.72	GNRH1 OXT PRL
4	response to glucocorticoid	GO:0051384	9.67	AREG IL6 OXT
5	regulation of MAPK cascade	GO:0043408	9.63	BMP15 FSHR GDF9
6	mammary gland development	GO:0030879	9.58	CYP19A1 PGR PRL
7	negative regulation of bone resorption	GO:0045779	9.54	FSHR IL6
8	gonad development	GO:0008406	9.52	AMH FSHR
9	response to molecule of bacterial origin	GO:0002237	9.51	CXCL8 TLR9
10	female gonad development	GO:0008585	9.5	CYP19A1 FOXL2 FSHR
11	response to prostaglandin E	GO:0034695	9.48	GNRH1 OXT
12	female gamete generation	GO:0007292	9.43	BMP15 FSHR GDF9
13	oocyte growth	GO:0001555	9.37	FOXL2 GDF9
14	uterus development	GO:0060065	9.33	CYP19A1 FOXL2 FSHR
15	regulation of signaling receptor activity	GO:0010469	9.32	AMH AREG BMP15 CXCL8 GDF9 GNRH1
16	response to peptide hormone	GO:0043434	9.26	AREG GNRH1 OXT TRPV1

Molecular functions related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.46	AMH GNRH1 OXT PRL
2	transforming growth factor beta receptor binding	GO:0005160	9.43	AMH BMP15 GDF9
3	cytokine activity	GO:0005125	9.35	AREG BMP15 CXCL8 GDF9 IL6
4	siRNA binding	GO:0035197	9.32	FMR1 TLR9
5	growth factor activity	GO:0008083	9.02	AMH AREG BMP15 GDF9 IL6

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Sources for Female Reproductive System Disease

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