Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: FML039
MIFTS: 47

Female Reproductive System Disease

Categories: Reproductive diseases
Genes Tissues Related diseases Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Female Reproductive System Disease

About this section

MalaCards integrated aliases for Female Reproductive System Disease:

Name: Female Reproductive System Disease 12 15
Female Reproductive System Disorder 73
Genital Diseases, Female 44

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:229
ICD9CM 35 629.9
MeSH 44 D005831
SNOMED-CT 68 38233001
Sources

Summaries for Female Reproductive System Disease

About this section
Disease Ontology : 12 A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes.

MalaCards based summary : Female Reproductive System Disease, also known as female reproductive system disorder, is related to fallopian tube disease and endometriosis of ovary, and has symptoms including menometrorrhagia, mastodynia and breast engorgement. An important gene associated with Female Reproductive System Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Gene Expression and ERK Signaling. The drugs Insulin, Globin Zinc and Hormones have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and cervix, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 The female reproductive system is made up of the internal and external sex organs that function in... more...

Sources

Related Diseases for Female Reproductive System Disease

About this section

Diseases related to Female Reproductive System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 fallopian tube disease 32.1 BRCA1 BRCA2 MAPK8IP1
2 endometriosis of ovary 32.1 AMH ESR1 PGR
3 endometriosis 32.1 VEGFA PTEN PGR GNRH1 ESR1
4 uterine anomalies 31.6 AKT1 AREG CDKN2A ERBB2 ESR1 MAPK8IP1
5 preterm premature rupture of the membranes 11.1
6 ectopic pregnancy 11.1
7 pelvic inflammatory disease 11.1
8 fallopian tube endometriosis 11.1
9 endosalpingiosis 11.1
10 endometriosis of intestine 11.1
11 endometriosis of pelvic peritoneum 11.1
12 endometriosis in scar of skin 11.1
13 endometriosis of rectovaginal septum and vagina 11.1
14 vaginal disease 11.1
15 hernia of ovary and fallopian tube 11.1
16 prolapse of female genital organ 11.1
17 amenorrhea 11.1
18 masters-allen syndrome 11.1
19 vulvovaginitis 11.1
20 gynatresia 11.1
21 parovarian cyst 11.1
22 bartholin's duct cyst 11.1
23 breast reconstruction 10.5 BRCA1 BRCA2
24 vulvar benign neoplasm 10.4 ESR1 PGR
25 trigonitis 10.4 ESR1 PGR
26 lung leiomyoma 10.4 ESR1 PGR
27 vulvar leiomyoma 10.4 ESR1 PGR
28 progesterone-receptor negative breast cancer 10.4 ERBB2 PGR
29 oncocytic breast carcinoma 10.4 ESR1 PGR
30 gastric papillary adenocarcinoma 10.4 ERBB2 TP53
31 predominantly cortical thymoma 10.4 ESR1 PGR
32 intracystic papillary adenoma 10.4 ERBB2 PGR
33 bladder squamous cell carcinoma 10.4 CDKN2A TP53
34 breast metaplastic carcinoma 10.4 ERBB2 PGR
35 rare adenocarcinoma of the breast 10.4 AKT1 TP53
36 vulvar dystrophy 10.4 CDKN2A PGR
37 mucinous stomach adenocarcinoma 10.4 PTEN VEGFA
38 bizarre leiomyoma 10.4 CDKN2A PGR
39 comedo carcinoma 10.4 ERBB2 ESR1
40 pharynx squamous cell carcinoma 10.4 AKT1 PTEN
41 sebaceous adenoma 10.4 ESR1 MLH1
42 infiltrating angiolipoma 10.4 CDKN2A VEGFA
43 endometrial stromal sarcoma 10.4 ESR1 PGR TP53
44 leukocyte disease 10.4 AKT1 TLR9 TP53
45 renal cell carcinoma, papillary, 1 10.4 ERBB2 PTEN TP53
46 suppression of tumorigenicity 12 10.4 AKT1 PTEN TP53
47 autosomal genetic disease 10.4 MLH1 TP53 VEGFA
48 colorectal adenocarcinoma 10.4 MLH1 TP53 VEGFA
49 laryngeal squamous cell carcinoma 10.4 CDKN2A TP53 VEGFA
50 prostate disease 10.4 AKT1 PTEN TP53

Graphical network of the top 20 diseases related to Female Reproductive System Disease:



Diseases related to Female Reproductive System Disease
Sources

Symptoms & Phenotypes for Female Reproductive System Disease

About this section

UMLS symptoms related to Female Reproductive System Disease:


menometrorrhagia, mastodynia, breast engorgement, nipple discharge, leukorrhea, vaginal pruritus, vaginal odor, vaginal discomfort, pruritus vulvae, genital itching, perineal pain female, genitalia external painful, menopausal symptoms, vaginal pain, burning feeling vagina, mastoscirrhus, discomfort of vulva

GenomeRNAi Phenotypes related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 10.28 MAPK8IP1
2 Decreased viability GR00221-A-1 10.28 AKT1 CDKN2A ESR1
3 Decreased viability GR00221-A-2 10.28 AKT1 ESR1
4 Decreased viability GR00221-A-3 10.28 AKT1 CDKN2A ERBB2
5 Decreased viability GR00221-A-4 10.28 AKT1 CDKN2A ERBB2 ESR1 MAPK8IP1
6 Decreased viability GR00301-A 10.28 MAPK8IP1
7 Decreased viability GR00342-S-3 10.28 MAPK8IP1
8 Decreased viability GR00402-S-2 10.28 AKT1 CDKN2A ERBB2 ESR1 MAPK8IP1
9 Decreased viability in esophageal squamous lineage GR00235-A 9.93 AMH BRCA1 BRCA2 CDKN2A ERBB2 ESR1
10 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.83 AKT1 BRCA1 BRCA2 CDKN2A ESS2 MLH1
11 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.83 AKT1 BRCA1 BRCA2 CDKN2A ESS2 MLH1
12 Increased cell death HMECs cells GR00103-A-0 9.43 AREG BRCA1 PGR PTEN PTPRN TP53

MGI Mouse Phenotypes related to Female Reproductive System Disease:

46 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.51 AKT1 AMH AREG BRCA1 BRCA2 CDKN2A
2 homeostasis/metabolism MP:0005376 10.5 AKT1 AMH AREG BRCA1 BRCA2 CDKN2A
3 cellular MP:0005384 10.44 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
4 behavior/neurological MP:0005386 10.39 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
5 growth/size/body region MP:0005378 10.38 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
6 immune system MP:0005387 10.38 AKT1 AREG BRCA1 BRCA2 CDKN2A ESR1
7 mortality/aging MP:0010768 10.38 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
8 digestive/alimentary MP:0005381 10.37 AREG BRCA1 BRCA2 CDKN2A ERBB2 ESR1
9 hematopoietic system MP:0005397 10.37 AKT1 AREG BRCA1 BRCA2 CDKN2A ESR1
10 integument MP:0010771 10.34 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
11 cardiovascular system MP:0005385 10.3 AKT1 AREG BRCA1 CDKN2A ERBB2 ESR1
12 embryo MP:0005380 10.28 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
13 neoplasm MP:0002006 10.25 AKT1 AMH BRCA1 BRCA2 CDKN2A ERBB2
14 nervous system MP:0003631 10.22 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
15 limbs/digits/tail MP:0005371 10.11 BRCA1 BRCA2 ERBB2 ESR1 PGR PTEN
16 muscle MP:0005369 10.11 AKT1 BRCA1 CDKN2A ERBB2 ESR1 PGR
17 liver/biliary system MP:0005370 10.1 AKT1 CDKN2A ESR1 GNRH1 MAPK8IP1 PTEN
18 reproductive system MP:0005389 10.06 AKT1 AMH AREG BRCA1 BRCA2 CDKN2A
19 normal MP:0002873 10.02 AKT1 BRCA1 BRCA2 ERBB2 ESR1 GNRH1
20 no phenotypic analysis MP:0003012 9.97 AMH CDKN2A ESR1 ESS2 MAPK8IP2 PGR
21 renal/urinary system MP:0005367 9.8 BRCA1 ESR1 GNRH1 PTEN TLR9 TP53
22 respiratory system MP:0005388 9.65 AKT1 BRCA1 CDKN2A ERBB2 ESR1 MLH1
23 skeleton MP:0005390 9.36 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
Sources

Drugs & Therapeutics for Female Reproductive System Disease

About this section

Drugs for Female Reproductive System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Insulin, Globin Zinc Not Applicable
2 Hormones Not Applicable
3 insulin Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Modifications of Nutritional Intake Upon Reproductive Hormones in Normal Women Completed NCT02233283 Not Applicable

Search NIH Clinical Center for Female Reproductive System Disease

Cochrane evidence based reviews: genital diseases, female

Sources

Genetic Tests for Female Reproductive System Disease

About this section
Sources

Anatomical Context for Female Reproductive System Disease

About this section

MalaCards organs/tissues related to Female Reproductive System Disease:

41
Uterus, Ovary, Cervix, Lung, Colon, Breast, Tonsil
Sources

Publications for Female Reproductive System Disease

About this section
Sources

Variations for Female Reproductive System Disease

About this section
Sources

Expression for Female Reproductive System Disease

About this section
Search GEO for disease gene expression data for Female Reproductive System Disease.
Sources

Pathways for Female Reproductive System Disease

About this section

Pathways related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Gene Expression 66
Show member pathways
 13.8 AKT1 BRCA1 CDKN2A ERBB2 ESR1 MLH1
2
ERK Signaling 64
Show member pathways
 13.72 AKT1 AREG BRCA1 CDKN2A ERBB2 ESR1
3
GPCR Pathway 64
Show member pathways
 13.69 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
4
TGF-Beta Pathway 64
Show member pathways
 13.52 AKT1 AREG BRCA1 ERBB2 GNRH1 MAPK8IP1
5
Akt Signaling 64
Show member pathways
 13.38 AKT1 AREG ERBB2 GNRH1 MAPK8IP1 MAPK8IP2
6
PAK Pathway 64
Show member pathways
 13.29 AKT1 AREG ERBB2 GNRH1 PTEN PTPRN
7
PI3K-Akt signaling pathway 37
Show member pathways
 12.98 AKT1 AREG BRCA1 ERBB2 PTEN TP53
8
Regulation of TP53 Activity 66
Show member pathways
 12.94 AKT1 BRCA1 CDKN2A MLH1 PTEN TP53
9
Endometrial cancer 37
Show member pathways
 12.77 AKT1 AREG BRCA2 CDKN2A ERBB2 MLH1
10
Development HGF signaling pathway 22
Show member pathways
 12.7 AKT1 ERBB2 ESR1 PTEN TP53
11
Pathways in cancer 37
12.7 AKT1 BRCA2 CDKN2A ERBB2 ESR1 MLH1
12
MAPK signaling pathway 37 1
12.69 AKT1 AREG ERBB2 MAPK8IP1 MAPK8IP2 TP53
13
Glioma 37
Show member pathways
 12.58 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
14
DNA Damage 4
12.5 BRCA1 BRCA2 CDKN2A MLH1 TP53
15
MicroRNAs in cancer 37
12.48 BRCA1 CDKN2A ERBB2 PTEN TP53 VEGFA
16
ErbB signaling pathway 1 37
Show member pathways
 12.46 AKT1 AREG ERBB2 TP53 VEGFA
17
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.38 AKT1 BRCA1 ESR1 VEGFA
18
DNA Damage Response 1
Show member pathways
 12.35 BRCA1 CDKN2A PTEN TP53
19
Proteoglycans in cancer 37
12.29 AKT1 ERBB2 ESR1 TP53 VEGFA
20
p53 Signaling 64
Show member pathways
 12.23 AKT1 BRCA1 PTEN TP53
21
Cell cycle Role of SCF complex in cell cycle regulation 22
Show member pathways
 12.21 BRCA1 CDKN2A ESR1 PGR
22
VEGF Signaling Pathway 61 67
Show member pathways
 12.21 AKT1 AREG PTEN VEGFA
23
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 12.18 AKT1 ERBB2 PTEN TP53
24
Cellular senescence (KEGG) 37
12.15 AKT1 CDKN2A PTEN TP53
25
Colorectal Cancer Metastasis 64
12.15 AKT1 MLH1 TLR9 TP53 VEGFA
26
AKT Signaling Pathway 67
12.13 AKT1 ERBB2 PTEN TP53
27
MAPK Pathway 72
Show member pathways
 12.02 AKT1 ERBB2 TLR9 TP53
28
Gastric cancer 37
Show member pathways
 11.99 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
29
Glioblastoma Multiforme 64
11.95 AKT1 CDKN2A PTEN TP53
30
DNA Damage Response (only ATM dependent) 1
11.92 AKT1 CDKN2A ERBB2 PTEN TP53
31
Integrated Breast Cancer Pathway 1
11.89 AKT1 BRCA1 BRCA2 ESR1 PTEN TP53
32
Fanconi anemia pathway 37 66
11.85 BRCA1 BRCA2 MLH1
33
Small cell lung cancer 37
11.85 AKT1 PTEN TP53
34
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 66
Show member pathways
 11.84 ERBB2 ESR1 VEGFA
35
Androgen receptor signaling pathway 1
11.83 AKT1 BRCA1 PTEN
36
TP53 Regulates Metabolic Genes 66
11.8 AKT1 PTEN TP53
37
BRCA1 Pathway 64
Show member pathways
 11.79 BRCA1 BRCA2 TP53
38
Bladder cancer 37 1
11.73 CDKN2A ERBB2 TP53 VEGFA
39
Regulation of TP53 Expression and Degradation 66
Show member pathways
 11.72 AKT1 CDKN2A TP53
40
Central carbon metabolism in cancer 37
11.66 AKT1 ERBB2 PTEN TP53
41
Pathways Affected in Adenoid Cystic Carcinoma 1
11.62 AKT1 BRCA1 ERBB2 PTEN TP53
42
Copper homeostasis 1
11.57 AKT1 PTEN TP53
43
HIF1Alpha Pathway 64
11.57 CDKN2A TP53 VEGFA
44
DNA damage_Role of Brca1 and Brca2 in DNA repair 22
11.56 AKT1 BRCA1 BRCA2 MLH1 TP53
45
Hepatitis C and Hepatocellular Carcinoma 1
11.52 AKT1 BRCA1 TP53 VEGFA
46
Integrated Cancer Pathway 1
11.46 AKT1 BRCA1 PTEN TP53
47
Ovarian tumor domain proteases 66
11.38 ESR1 PTEN TP53
48
Platinum drug resistance 37
11.3 AKT1 BRCA1 CDKN2A ERBB2 MLH1 TP53
49
Aurora A signaling 1
11.28 AKT1 BRCA1 TP53
Sources

GO Terms for Female Reproductive System Disease

About this section

Cellular components related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.83 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
2 protein-containing complex GO:0032991 9.63 AKT1 BRCA1 BRCA2 ESR1 MAPK8IP2 TP53
3 nucleus GO:0005634 9.5 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2

Biological processes related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.98 AMH AREG GNRH1 MAPK8IP2 VEGFA
2 regulation of apoptotic process GO:0042981 9.94 AKT1 BRCA1 ESR1 TP53
3 protein deubiquitination GO:0016579 9.93 BRCA1 ESR1 PTEN TP53
4 negative regulation of gene expression GO:0010629 9.92 AKT1 ESR1 PGR VEGFA
5 cell-cell signaling GO:0007267 9.89 AMH AREG GNRH1 PGR
6 aging GO:0007568 9.86 AKT1 AMH GNRH1 PTEN
7 cell proliferation GO:0008283 9.85 AKT1 AREG BRCA2 ERBB2 PTEN TP53
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.81 AREG TP53 VEGFA
9 negative regulation of apoptotic process GO:0043066 9.8 AKT1 ERBB2 GNRH1 MAPK8IP1 PTEN TP53
10 response to organic cyclic compound GO:0014070 9.76 AMH AREG GNRH1 PTEN
11 response to estrogen GO:0043627 9.75 BRCA1 ESR1 PTPRN
12 cellular response to hypoxia GO:0071456 9.73 AKT1 PTEN TP53 VEGFA
13 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.72 BRCA1 BRCA2 MLH1
14 response to estradiol GO:0032355 9.71 AREG BRCA2 ESR1 PTEN
15 replicative senescence GO:0090399 9.64 CDKN2A TP53
16 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.61 ESR1 TP53
17 negative regulation of cell size GO:0045792 9.61 AKT1 PTEN
18 positive regulation of transcription by RNA polymerase II GO:0045944 9.61 AKT1 BRCA1 CDKN2A ESR1 PGR PTPRN
19 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.57 CDKN2A PTEN
20 negative regulation of immature T cell proliferation in thymus GO:0033088 9.54 CDKN2A ERBB2
21 cellular response to decreased oxygen levels GO:0036294 9.51 AKT1 PTEN
22 mammary gland alveolus development GO:0060749 9.5 AREG ESR1 VEGFA
23 chordate embryonic development GO:0043009 9.49 BRCA1 BRCA2
24 epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 9.48 AREG ESR1
25 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.33 BRCA1 BRCA2 TP53
26 positive regulation of gene expression GO:0010628 9.28 AKT1 AMH BRCA1 CDKN2A ERBB2 PTEN
27 nervous system development GO:0007399 10.02 AKT1 ERBB2 ESS2 PTEN VEGFA
28 cellular response to DNA damage stimulus GO:0006974 10 AKT1 BRCA1 BRCA2 MLH1 TP53
29 positive regulation of transcription, DNA-templated GO:0045893 10 AKT1 BRCA1 BRCA2 CDKN2A ESR1 TP53

Molecular functions related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.7 AKT1 CDKN2A ESR1 MAPK8IP1 MAPK8IP2 PTEN
2 identical protein binding GO:0042802 9.61 AKT1 BRCA1 BRCA2 ERBB2 ESR1 PGR
3 nitric-oxide synthase regulator activity GO:0030235 9.37 AKT1 ESR1
4 MAP-kinase scaffold activity GO:0005078 9.32 MAPK8IP1 MAPK8IP2
5 enzyme binding GO:0019899 9.17 AKT1 BRCA1 ESR1 MLH1 PGR PTEN
6 protein binding GO:0005515 10.19 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
Sources

Sources for Female Reproductive System Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....