MCID: FML039
MIFTS: 47

Female Reproductive System Disease

Categories: Reproductive diseases

Aliases & Classifications for Female Reproductive System Disease

MalaCards integrated aliases for Female Reproductive System Disease:

Name: Female Reproductive System Disease 12 15
Female Reproductive System Disorder 73
Genital Diseases, Female 44

Classifications:



External Ids:

Disease Ontology 12 DOID:229
ICD9CM 35 629.9
MeSH 44 D005831
SNOMED-CT 68 38233001

Summaries for Female Reproductive System Disease

Disease Ontology : 12 A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes.

MalaCards based summary : Female Reproductive System Disease, also known as female reproductive system disorder, is related to fallopian tube disease and endometriosis of ovary, and has symptoms including menometrorrhagia, mastodynia and breast engorgement. An important gene associated with Female Reproductive System Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Gene Expression and ERK Signaling. The drugs Insulin, Globin Zinc and Hormones have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and cervix, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 The female reproductive system is made up of the internal and external sex organs that function in... more...

Related Diseases for Female Reproductive System Disease

Diseases related to Female Reproductive System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 fallopian tube disease 32.1 BRCA1 BRCA2 MAPK8IP1
2 endometriosis of ovary 32.1 AMH ESR1 PGR
3 endometriosis 32.1 VEGFA PTEN PGR GNRH1 ESR1
4 uterine anomalies 31.6 AKT1 AREG CDKN2A ERBB2 ESR1 MAPK8IP1
5 preterm premature rupture of the membranes 11.1
6 ectopic pregnancy 11.1
7 pelvic inflammatory disease 11.1
8 fallopian tube endometriosis 11.1
9 endosalpingiosis 11.1
10 endometriosis of intestine 11.1
11 endometriosis of pelvic peritoneum 11.1
12 endometriosis in scar of skin 11.1
13 endometriosis of rectovaginal septum and vagina 11.1
14 vaginal disease 11.1
15 hernia of ovary and fallopian tube 11.1
16 prolapse of female genital organ 11.1
17 amenorrhea 11.1
18 masters-allen syndrome 11.1
19 vulvovaginitis 11.1
20 gynatresia 11.1
21 parovarian cyst 11.1
22 bartholin's duct cyst 11.1
23 breast reconstruction 10.5 BRCA1 BRCA2
24 vulvar benign neoplasm 10.4 ESR1 PGR
25 trigonitis 10.4 ESR1 PGR
26 lung leiomyoma 10.4 ESR1 PGR
27 vulvar leiomyoma 10.4 ESR1 PGR
28 progesterone-receptor negative breast cancer 10.4 ERBB2 PGR
29 oncocytic breast carcinoma 10.4 ESR1 PGR
30 gastric papillary adenocarcinoma 10.4 ERBB2 TP53
31 predominantly cortical thymoma 10.4 ESR1 PGR
32 intracystic papillary adenoma 10.4 ERBB2 PGR
33 bladder squamous cell carcinoma 10.4 CDKN2A TP53
34 breast metaplastic carcinoma 10.4 ERBB2 PGR
35 rare adenocarcinoma of the breast 10.4 AKT1 TP53
36 vulvar dystrophy 10.4 CDKN2A PGR
37 mucinous stomach adenocarcinoma 10.4 PTEN VEGFA
38 bizarre leiomyoma 10.4 CDKN2A PGR
39 comedo carcinoma 10.4 ERBB2 ESR1
40 pharynx squamous cell carcinoma 10.4 AKT1 PTEN
41 sebaceous adenoma 10.4 ESR1 MLH1
42 infiltrating angiolipoma 10.4 CDKN2A VEGFA
43 endometrial stromal sarcoma 10.4 ESR1 PGR TP53
44 leukocyte disease 10.4 AKT1 TLR9 TP53
45 renal cell carcinoma, papillary, 1 10.4 ERBB2 PTEN TP53
46 suppression of tumorigenicity 12 10.4 AKT1 PTEN TP53
47 autosomal genetic disease 10.4 MLH1 TP53 VEGFA
48 colorectal adenocarcinoma 10.4 MLH1 TP53 VEGFA
49 laryngeal squamous cell carcinoma 10.4 CDKN2A TP53 VEGFA
50 prostate disease 10.4 AKT1 PTEN TP53

Graphical network of the top 20 diseases related to Female Reproductive System Disease:



Diseases related to Female Reproductive System Disease

Symptoms & Phenotypes for Female Reproductive System Disease

UMLS symptoms related to Female Reproductive System Disease:


menometrorrhagia, mastodynia, breast engorgement, nipple discharge, leukorrhea, vaginal pruritus, vaginal odor, vaginal discomfort, pruritus vulvae, genital itching, perineal pain female, genitalia external painful, menopausal symptoms, vaginal pain, burning feeling vagina, mastoscirrhus, discomfort of vulva

GenomeRNAi Phenotypes related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 10.28 MAPK8IP1
2 Decreased viability GR00221-A-1 10.28 AKT1 CDKN2A ESR1
3 Decreased viability GR00221-A-2 10.28 AKT1 ESR1
4 Decreased viability GR00221-A-3 10.28 AKT1 CDKN2A ERBB2
5 Decreased viability GR00221-A-4 10.28 AKT1 CDKN2A ERBB2 ESR1 MAPK8IP1
6 Decreased viability GR00301-A 10.28 MAPK8IP1
7 Decreased viability GR00342-S-3 10.28 MAPK8IP1
8 Decreased viability GR00402-S-2 10.28 AKT1 CDKN2A ERBB2 ESR1 MAPK8IP1
9 Decreased viability in esophageal squamous lineage GR00235-A 9.93 AMH BRCA1 BRCA2 CDKN2A ERBB2 ESR1
10 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.83 AKT1 BRCA1 BRCA2 CDKN2A ESS2 MLH1
11 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.83 AKT1 BRCA1 BRCA2 CDKN2A ESS2 MLH1
12 Increased cell death HMECs cells GR00103-A-0 9.43 AREG BRCA1 PGR PTEN PTPRN TP53

MGI Mouse Phenotypes related to Female Reproductive System Disease:

46 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.51 AKT1 AMH AREG BRCA1 BRCA2 CDKN2A
2 homeostasis/metabolism MP:0005376 10.5 AKT1 AMH AREG BRCA1 BRCA2 CDKN2A
3 cellular MP:0005384 10.44 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
4 behavior/neurological MP:0005386 10.39 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
5 growth/size/body region MP:0005378 10.38 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
6 immune system MP:0005387 10.38 AKT1 AREG BRCA1 BRCA2 CDKN2A ESR1
7 mortality/aging MP:0010768 10.38 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
8 digestive/alimentary MP:0005381 10.37 AREG BRCA1 BRCA2 CDKN2A ERBB2 ESR1
9 hematopoietic system MP:0005397 10.37 AKT1 AREG BRCA1 BRCA2 CDKN2A ESR1
10 integument MP:0010771 10.34 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
11 cardiovascular system MP:0005385 10.3 AKT1 AREG BRCA1 CDKN2A ERBB2 ESR1
12 embryo MP:0005380 10.28 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
13 neoplasm MP:0002006 10.25 AKT1 AMH BRCA1 BRCA2 CDKN2A ERBB2
14 nervous system MP:0003631 10.22 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
15 limbs/digits/tail MP:0005371 10.11 BRCA1 BRCA2 ERBB2 ESR1 PGR PTEN
16 muscle MP:0005369 10.11 AKT1 BRCA1 CDKN2A ERBB2 ESR1 PGR
17 liver/biliary system MP:0005370 10.1 AKT1 CDKN2A ESR1 GNRH1 MAPK8IP1 PTEN
18 reproductive system MP:0005389 10.06 AKT1 AMH AREG BRCA1 BRCA2 CDKN2A
19 normal MP:0002873 10.02 AKT1 BRCA1 BRCA2 ERBB2 ESR1 GNRH1
20 no phenotypic analysis MP:0003012 9.97 AMH CDKN2A ESR1 ESS2 MAPK8IP2 PGR
21 renal/urinary system MP:0005367 9.8 BRCA1 ESR1 GNRH1 PTEN TLR9 TP53
22 respiratory system MP:0005388 9.65 AKT1 BRCA1 CDKN2A ERBB2 ESR1 MLH1
23 skeleton MP:0005390 9.36 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1

Drugs & Therapeutics for Female Reproductive System Disease

Drugs for Female Reproductive System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Insulin, Globin Zinc Not Applicable
2 Hormones Not Applicable
3 insulin Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Modifications of Nutritional Intake Upon Reproductive Hormones in Normal Women Completed NCT02233283 Not Applicable

Search NIH Clinical Center for Female Reproductive System Disease

Cochrane evidence based reviews: genital diseases, female

Genetic Tests for Female Reproductive System Disease

Anatomical Context for Female Reproductive System Disease

MalaCards organs/tissues related to Female Reproductive System Disease:

41
Uterus, Ovary, Cervix, Lung, Colon, Breast, Tonsil

Publications for Female Reproductive System Disease

Variations for Female Reproductive System Disease

Expression for Female Reproductive System Disease

Search GEO for disease gene expression data for Female Reproductive System Disease.

Pathways for Female Reproductive System Disease

Pathways related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 AKT1 BRCA1 CDKN2A ERBB2 ESR1 MLH1
2
Show member pathways
13.72 AKT1 AREG BRCA1 CDKN2A ERBB2 ESR1
3
Show member pathways
13.69 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
4
Show member pathways
13.52 AKT1 AREG BRCA1 ERBB2 GNRH1 MAPK8IP1
5
Show member pathways
13.38 AKT1 AREG ERBB2 GNRH1 MAPK8IP1 MAPK8IP2
6
Show member pathways
13.29 AKT1 AREG ERBB2 GNRH1 PTEN PTPRN
7
Show member pathways
12.98 AKT1 AREG BRCA1 ERBB2 PTEN TP53
8
Show member pathways
12.94 AKT1 BRCA1 CDKN2A MLH1 PTEN TP53
9
Show member pathways
12.77 AKT1 AREG BRCA2 CDKN2A ERBB2 MLH1
10
Show member pathways
12.7 AKT1 ERBB2 ESR1 PTEN TP53
11 12.7 AKT1 BRCA2 CDKN2A ERBB2 ESR1 MLH1
12 12.69 AKT1 AREG ERBB2 MAPK8IP1 MAPK8IP2 TP53
13
Show member pathways
12.58 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
14 12.5 BRCA1 BRCA2 CDKN2A MLH1 TP53
15 12.48 BRCA1 CDKN2A ERBB2 PTEN TP53 VEGFA
16
Show member pathways
12.46 AKT1 AREG ERBB2 TP53 VEGFA
17
Show member pathways
12.38 AKT1 BRCA1 ESR1 VEGFA
18
Show member pathways
12.35 BRCA1 CDKN2A PTEN TP53
19 12.29 AKT1 ERBB2 ESR1 TP53 VEGFA
20
Show member pathways
12.23 AKT1 BRCA1 PTEN TP53
21
Show member pathways
12.21 BRCA1 CDKN2A ESR1 PGR
22
Show member pathways
12.21 AKT1 AREG PTEN VEGFA
23
Show member pathways
12.18 AKT1 ERBB2 PTEN TP53
24 12.15 AKT1 CDKN2A PTEN TP53
25 12.15 AKT1 MLH1 TLR9 TP53 VEGFA
26 12.13 AKT1 ERBB2 PTEN TP53
27
Show member pathways
12.02 AKT1 ERBB2 TLR9 TP53
28
Show member pathways
11.99 AKT1 BRCA1 BRCA2 CDKN2A ERBB2 ESR1
29 11.95 AKT1 CDKN2A PTEN TP53
30 11.92 AKT1 CDKN2A ERBB2 PTEN TP53
31 11.89 AKT1 BRCA1 BRCA2 ESR1 PTEN TP53
32 11.85 BRCA1 BRCA2 MLH1
33 11.85 AKT1 PTEN TP53
34
Show member pathways
11.84 ERBB2 ESR1 VEGFA
35 11.83 AKT1 BRCA1 PTEN
36 11.8 AKT1 PTEN TP53
37
Show member pathways
11.79 BRCA1 BRCA2 TP53
38 11.73 CDKN2A ERBB2 TP53 VEGFA
39
Show member pathways
11.72 AKT1 CDKN2A TP53
40 11.66 AKT1 ERBB2 PTEN TP53
41 11.62 AKT1 BRCA1 ERBB2 PTEN TP53
42 11.57 AKT1 PTEN TP53
43 11.57 CDKN2A TP53 VEGFA
44 11.56 AKT1 BRCA1 BRCA2 MLH1 TP53
45 11.52 AKT1 BRCA1 TP53 VEGFA
46 11.46 AKT1 BRCA1 PTEN TP53
47 11.38 ESR1 PTEN TP53
48 11.3 AKT1 BRCA1 CDKN2A ERBB2 MLH1 TP53
49 11.28 AKT1 BRCA1 TP53

GO Terms for Female Reproductive System Disease

Cellular components related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.83 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2
2 protein-containing complex GO:0032991 9.63 AKT1 BRCA1 BRCA2 ESR1 MAPK8IP2 TP53
3 nucleus GO:0005634 9.5 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2

Biological processes related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.98 AMH AREG GNRH1 MAPK8IP2 VEGFA
2 regulation of apoptotic process GO:0042981 9.94 AKT1 BRCA1 ESR1 TP53
3 protein deubiquitination GO:0016579 9.93 BRCA1 ESR1 PTEN TP53
4 negative regulation of gene expression GO:0010629 9.92 AKT1 ESR1 PGR VEGFA
5 cell-cell signaling GO:0007267 9.89 AMH AREG GNRH1 PGR
6 aging GO:0007568 9.86 AKT1 AMH GNRH1 PTEN
7 cell proliferation GO:0008283 9.85 AKT1 AREG BRCA2 ERBB2 PTEN TP53
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.81 AREG TP53 VEGFA
9 negative regulation of apoptotic process GO:0043066 9.8 AKT1 ERBB2 GNRH1 MAPK8IP1 PTEN TP53
10 response to organic cyclic compound GO:0014070 9.76 AMH AREG GNRH1 PTEN
11 response to estrogen GO:0043627 9.75 BRCA1 ESR1 PTPRN
12 cellular response to hypoxia GO:0071456 9.73 AKT1 PTEN TP53 VEGFA
13 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.72 BRCA1 BRCA2 MLH1
14 response to estradiol GO:0032355 9.71 AREG BRCA2 ESR1 PTEN
15 replicative senescence GO:0090399 9.64 CDKN2A TP53
16 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.61 ESR1 TP53
17 negative regulation of cell size GO:0045792 9.61 AKT1 PTEN
18 positive regulation of transcription by RNA polymerase II GO:0045944 9.61 AKT1 BRCA1 CDKN2A ESR1 PGR PTPRN
19 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.57 CDKN2A PTEN
20 negative regulation of immature T cell proliferation in thymus GO:0033088 9.54 CDKN2A ERBB2
21 cellular response to decreased oxygen levels GO:0036294 9.51 AKT1 PTEN
22 mammary gland alveolus development GO:0060749 9.5 AREG ESR1 VEGFA
23 chordate embryonic development GO:0043009 9.49 BRCA1 BRCA2
24 epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 9.48 AREG ESR1
25 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.33 BRCA1 BRCA2 TP53
26 positive regulation of gene expression GO:0010628 9.28 AKT1 AMH BRCA1 CDKN2A ERBB2 PTEN
27 nervous system development GO:0007399 10.02 AKT1 ERBB2 ESS2 PTEN VEGFA
28 cellular response to DNA damage stimulus GO:0006974 10 AKT1 BRCA1 BRCA2 MLH1 TP53
29 positive regulation of transcription, DNA-templated GO:0045893 10 AKT1 BRCA1 BRCA2 CDKN2A ESR1 TP53

Molecular functions related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.7 AKT1 CDKN2A ESR1 MAPK8IP1 MAPK8IP2 PTEN
2 identical protein binding GO:0042802 9.61 AKT1 BRCA1 BRCA2 ERBB2 ESR1 PGR
3 nitric-oxide synthase regulator activity GO:0030235 9.37 AKT1 ESR1
4 MAP-kinase scaffold activity GO:0005078 9.32 MAPK8IP1 MAPK8IP2
5 enzyme binding GO:0019899 9.17 AKT1 BRCA1 ESR1 MLH1 PGR PTEN
6 protein binding GO:0005515 10.19 AKT1 AREG BRCA1 BRCA2 CDKN2A ERBB2

Sources for Female Reproductive System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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