MCID: FML039
MIFTS: 39

Female Reproductive System Disease

Categories: Reproductive diseases

Aliases & Classifications for Female Reproductive System Disease

MalaCards integrated aliases for Female Reproductive System Disease:

Name: Female Reproductive System Disease 12 15
Female Reproductive System Disorder 73
Genital Diseases, Female 44

Classifications:



External Ids:

Disease Ontology 12 DOID:229
ICD9CM 35 629.9
MeSH 44 D005831

Summaries for Female Reproductive System Disease

Disease Ontology : 12 A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes.

MalaCards based summary : Female Reproductive System Disease, also known as female reproductive system disorder, is related to preterm premature rupture of the membranes and endometriosis, and has symptoms including leukorrhea, mastodynia and genital itching. An important gene associated with Female Reproductive System Disease is AMH (Anti-Mullerian Hormone), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Hormones and insulin have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and ovary, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Female Reproductive System Disease

Diseases related to Female Reproductive System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 preterm premature rupture of the membranes 32.7 CXCL8 IL6 SERPINH1
2 endometriosis 32.2 CXCL8 CYP19A1 GNRH1 IL6 PGR
3 uterine anomalies 31.8 CXCL8 CYP19A1 IL6 OXT SERPINH1 TLR9
4 pituitary infarct 11.1 GNRH1 PRL
5 endometriosis of uterus 11.0 GNRH1 PRL
6 precocious puberty, male-limited 11.0 CYP19A1 FSHR
7 intracystic papillary adenoma 11.0 PGR PRL
8 mccune-albright syndrome 11.0 AMH CYP19A1 PRL
9 oocyte maturation defect 1 11.0 BMP15 CYP19A1
10 endometriosis of ovary 11.0 AMH CYP19A1 PGR
11 mammographic density 11.0 CYP19A1 PGR PRL
12 hypogonadotropism 11.0 GNRH1 PRL
13 hypogonadotropic hypogonadism 23 without anosmia 11.0 FSHR GNRH1
14 recurrent corneal erosion 11.0 CXCL8 IL6
15 hypoactive sexual desire disorder 11.0 CYP19A1 SHBG
16 bagassosis 10.9 CXCL8 IL6
17 androgenic alopecia 10.9 CYP19A1 PRL SHBG
18 ectopic pregnancy 10.9
19 hyperprolactinemia 10.9 GNRH1 PRL SHBG
20 juvenile nasopharyngeal angiofibroma 10.9 CYP19A1 PGR TLR9
21 funisitis 10.9 CXCL8 IL6 SERPINH1
22 vaginal disease 10.9 CXCL8 IL6 SERPINH1
23 cervical incompetence 10.9 IL6 SERPINH1
24 ovarian cyst 10.9 FOXL2 NOBOX PRL
25 vaginitis 10.9 CXCL8 IL6 SERPINH1
26 ovarian hyperstimulation syndrome 10.9 AMH CYP19A1 FSHR GNRH1
27 nasal cavity disease 10.9 CXCL8 TLR9 TRPV1
28 eye lymphoma 10.9 IL6 TLR9
29 nose disease 10.9 CXCL8 TLR9 TRPV1
30 hypothalamic disease 10.9 GNRH1 PRL
31 pulpitis 10.9 CXCL8 IL6 TRPV1
32 upper respiratory tract disease 10.9 CXCL8 TLR9 TRPV1
33 interstitial cystitis 10.8 CXCL8 IL6 TRPV1
34 chiasmal syndrome 10.8 GNRH1 PRL
35 hypersensitivity reaction disease 10.8 IL6 TLR9 TRPV1
36 leiomyoma 10.8 CYP19A1 GNRH1 PGR
37 progesterone-receptor positive breast cancer 10.8 CYP19A1 PGR
38 esophagitis 10.8 CXCL8 IL6 TRPV1
39 breast disease 10.8 PGR PRL SHBG
40 varicocele 10.8 AMH GNRH1 PRL SHBG
41 cystitis 10.8 CXCL8 IL6 TRPV1
42 mouth disease 10.8 IL6 TLR9 TRPV1
43 cryptorchidism, unilateral or bilateral 10.8 AMH CYP19A1 GNRH1 SHBG
44 androgen insensitivity, partial 10.8 CYP19A1 SHBG
45 sexual disorder 10.8 OXT PRL SHBG
46 hyperandrogenism 10.8 CYP19A1 GNRH1 PRL SHBG
47 glucose metabolism disease 10.8 IL6 TLR9 TRPV1
48 acute transverse myelitis 10.8 CXCL8 IL6
49 urinary system disease 10.8 IL6 TLR9 TRPV1
50 gonadal disease 10.8 AMH FSHR GNRH1 SHBG

Graphical network of the top 20 diseases related to Female Reproductive System Disease:



Diseases related to Female Reproductive System Disease

Symptoms & Phenotypes for Female Reproductive System Disease

UMLS symptoms related to Female Reproductive System Disease:


leukorrhea, mastodynia, genital itching, pruritus vulvae, vaginal pruritus, breast engorgement, nipple discharge, menometrorrhagia, perineal pain female, genitalia external painful, vaginal odor, menopausal symptoms, vaginal discomfort, vaginal pain, burning feeling vagina, mastoscirrhus, discomfort of vulva

MGI Mouse Phenotypes related to Female Reproductive System Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.2 AREG IL6 BMP15 CYP19A1 NOBOX OXT
2 homeostasis/metabolism MP:0005376 10.07 GNRH1 AREG IL6 CYP19A1 OXT FOXL2
3 digestive/alimentary MP:0005381 9.91 GNRH1 AREG IL6 CYP19A1 OXT TLR9
4 integument MP:0010771 9.85 AREG IL6 CYP19A1 OXT FMR1 PGR
5 neoplasm MP:0002006 9.5 GNRH1 IL6 PGR FSHR AMH TRPV1
6 reproductive system MP:0005389 9.5 IL6 BMP15 CYP19A1 NOBOX OXT FMR1

Drugs & Therapeutics for Female Reproductive System Disease

Drugs for Female Reproductive System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Not Applicable
2 insulin Not Applicable
3 Insulin, Globin Zinc Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Modifications of Nutritional Intake Upon Reproductive Hormones in Normal Women Completed NCT02233283 Not Applicable

Search NIH Clinical Center for Female Reproductive System Disease

Cochrane evidence based reviews: genital diseases, female

Genetic Tests for Female Reproductive System Disease

Anatomical Context for Female Reproductive System Disease

MalaCards organs/tissues related to Female Reproductive System Disease:

41
Cervix, Uterus, Ovary

Publications for Female Reproductive System Disease

Variations for Female Reproductive System Disease

Expression for Female Reproductive System Disease

Search GEO for disease gene expression data for Female Reproductive System Disease.

Pathways for Female Reproductive System Disease

GO Terms for Female Reproductive System Disease

Cellular components related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 AMH BMP15 CXCL8 GDF9 GNRH1 IL6
2 extracellular space GO:0005615 9.4 AMH AREG BMP15 CXCL8 GDF9 GNRH1

Biological processes related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 BMP signaling pathway GO:0030509 9.73 AMH BMP15 GDF9
2 response to organic cyclic compound GO:0014070 9.73 AMH AREG GNRH1 OXT
3 female pregnancy GO:0007565 9.72 GNRH1 OXT PRL
4 response to glucocorticoid GO:0051384 9.67 AREG IL6 OXT
5 regulation of MAPK cascade GO:0043408 9.63 BMP15 FSHR GDF9
6 mammary gland development GO:0030879 9.58 CYP19A1 PGR PRL
7 negative regulation of bone resorption GO:0045779 9.54 FSHR IL6
8 gonad development GO:0008406 9.52 AMH FSHR
9 response to molecule of bacterial origin GO:0002237 9.51 CXCL8 TLR9
10 female gonad development GO:0008585 9.5 CYP19A1 FOXL2 FSHR
11 response to prostaglandin E GO:0034695 9.48 GNRH1 OXT
12 female gamete generation GO:0007292 9.43 BMP15 FSHR GDF9
13 oocyte growth GO:0001555 9.37 FOXL2 GDF9
14 uterus development GO:0060065 9.33 CYP19A1 FOXL2 FSHR
15 regulation of signaling receptor activity GO:0010469 9.32 AMH AREG BMP15 CXCL8 GDF9 GNRH1
16 response to peptide hormone GO:0043434 9.26 AREG GNRH1 OXT TRPV1

Molecular functions related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.46 AMH GNRH1 OXT PRL
2 transforming growth factor beta receptor binding GO:0005160 9.43 AMH BMP15 GDF9
3 cytokine activity GO:0005125 9.35 AREG BMP15 CXCL8 GDF9 IL6
4 siRNA binding GO:0035197 9.32 FMR1 TLR9
5 growth factor activity GO:0008083 9.02 AMH AREG BMP15 GDF9 IL6

Sources for Female Reproductive System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....