MCID: FML031
MIFTS: 38

Female Stress Incontinence

Categories: Nephrological diseases

Aliases & Classifications for Female Stress Incontinence

MalaCards integrated aliases for Female Stress Incontinence:

Name: Female Stress Incontinence 38 12 15 73
Female Urinary Stress Incontinence 12
Stress Incontinence - Female 12

Classifications:



External Ids:

Disease Ontology 12 DOID:724
ICD9CM 35 625.6
NCIt 50 C35042
SNOMED-CT 68 60241006
UMLS 73 C0038437

Summaries for Female Stress Incontinence

MalaCards based summary : Female Stress Incontinence, also known as female urinary stress incontinence, is related to amelogenesis imperfecta, type ib and tardive dyskinesia, and has symptoms including pain and other symptoms associated with female genital organs, mittelschmerz and unspecified symptom associated with female genital organs. An important gene associated with Female Stress Incontinence is MEOX2 (Mesenchyme Homeobox 2), and among its related pathways/superpathways are Tamoxifen metabolism and Melatonin metabolism and effects. The drugs Sulfamethazine and Nitrofurantoin have been mentioned in the context of this disorder. Affiliated tissues include testes and bone, and related phenotype is taste/olfaction.

Related Diseases for Female Stress Incontinence

Diseases related to Female Stress Incontinence via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 amelogenesis imperfecta, type ib 10.0 CYP1A2 CYP2D6
2 tardive dyskinesia 10.0 CYP1A2 CYP2D6
3 acetaminophen metabolism 9.9 CYP1A2 CYP2D6

Comorbidity relations with Female Stress Incontinence via Phenotypic Disease Network (PDN):


Hypothyroidism Leukoplakia of Vagina
Myofibroma Postmenopausal Atrophic Vaginitis
Submucous Uterine Fibroid Subserous Uterine Fibroid
Trigonitis Urethral Intrinsic Sphincter Deficiency

Symptoms & Phenotypes for Female Stress Incontinence

UMLS symptoms related to Female Stress Incontinence:


pain and other symptoms associated with female genital organs, mittelschmerz, unspecified symptom associated with female genital organs, other specified symptoms associated with female genital organs, female genital pain and other symptoms

MGI Mouse Phenotypes related to Female Stress Incontinence:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.8 MEOX2 SLC6A1 TERT

Drugs & Therapeutics for Female Stress Incontinence

Drugs for Female Stress Incontinence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethazine Approved, Investigational, Vet_approved Not Applicable 57-68-1 5327
2
Nitrofurantoin Approved, Vet_approved 67-20-9 5353830
3
Trimethoprim Approved, Vet_approved 738-70-5 5578
4
Levofloxacin Approved, Investigational 100986-85-4 149096
5
Sulfamethoxazole Approved 723-46-6 5329
6
Ofloxacin Approved 82419-36-1 4583
7
Silicon Approved, Investigational Not Applicable 7440-21-3 4082203
8 Anesthetics Not Applicable
9 Antibiotics, Antitubercular
10 Trimethoprim, Sulfamethoxazole Drug Combination
11 Anti-Bacterial Agents

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Treatment of Female Stress Urinary Incontinence: Study Comparing Two Suburethral Slings, Retropubic Approach (TVT) and Trans-Obturator (TVT-O) Approach Unknown status NCT00135616 Phase 4
2 A Randomized Controlled Study Comparing Three Single-incision Devices for Female Urinary Stress Incontinence Completed NCT00751088 Phase 4
3 TVTO™ X TVTS ™ for Treatment of Stress Urinary Incontinence Completed NCT01095159 Phase 4
4 Laparoscopic Burch Colposuspension Versus Transobturatory Tape for the Treatment of Female Urinary Stress Incontinence Withdrawn NCT00573703 Phase 4
5 Randomized, Multicenter Trial Comparing TVT With TVT-O for Treatment of Female Urinary Incontinence Unknown status NCT00379314 Phase 3
6 Autologous Rectus Sheath Fascia Versus Midurethral Transobturator Tension Free Vaginal Not yet recruiting NCT03473041 Phase 3
7 Feasibility of Comparing Two Surgical Treatment of Female Urodynamic Stress Completed NCT01230450 Phase 1
8 Lyrette: Renewing Continence Objective and Subjective Efficacy Study Unknown status NCT01455779 Not Applicable
9 The Prefyx PPS™ System eRegistry Unknown status NCT00688181
10 A Comparison of Electrical Pudendal Nerve Stimulation and Pelvic Floor Muscle Training for Female Stress Incontinence Completed NCT01763762 Not Applicable
11 A Feasibility Device Study to Prevent Female Urinary Stress Incontinence Completed NCT03010800 Not Applicable
12 TVT Versus TOT in Urinary Stress Incontinence With No Intrinsic Sphincter Deficiency Completed NCT01903590 Not Applicable
13 Posture in Abdominopelvic Training in Women SUI Completed NCT03727945 Not Applicable
14 Electrostimulation PROTOCOL Incontinence Completed NCT03682926 Not Applicable
15 Incidence of Symptomatic and Asymptomatic Bacteriuria After Urodynamic Study in Women Completed NCT03106103
16 TVT-ABBREVO Versus SERASIS for the Treatment of Female Urinary Stress Incontinence: 1 Year Outcomes of a Comparative Study With 2 Trans-obturator Sub Mid Urethral Slings Active, not recruiting NCT02867748 Not Applicable
17 Continence Pessary Versus Disposable Intravaginal Device Trial Not yet recruiting NCT03174431 Not Applicable
18 Development and Evaluation of a New Diagnostic Test in Female Urinary Stress Incontinence Terminated NCT01563653 Not Applicable
19 Collection of Long Term Patient Outcomes Data Following Implantation of AMS Surgical Devices Terminated NCT01673360

Search NIH Clinical Center for Female Stress Incontinence

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Female Stress Incontinence cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Female Stress Incontinence:
AMDC, autologous muscle-derived cells for urinary incontinence
ICES13, autologous myoblasts for stress urinary incontinence
Embryonic/Adult Cultured Cells Related to Female Stress Incontinence:
Autologous muscle-derived cells PMIDs: 23260547
Muscle-derived myoblasts

Genetic Tests for Female Stress Incontinence

Anatomical Context for Female Stress Incontinence

MalaCards organs/tissues related to Female Stress Incontinence:

41
Testes, Bone

Publications for Female Stress Incontinence

Articles related to Female Stress Incontinence:

(show top 50) (show all 123)
# Title Authors Year
1
The use of polyacrylamide hydrogel in the setting of failed female stress incontinence surgery. ( 29319483 )
2017
2
Laser procedure for female urinary stress incontinence: A review of the literature. ( 29033365 )
2017
3
Is the adjustable TVA mesh effective for the long-term treatment of female stress incontinence? ( 27496772 )
2016
4
Definition of Success after Surgery for Female Stress Incontinence or Voiding Dysfunction: An Attempt at Standardization. ( 28723368 )
2016
5
Efficacy of Electrical Pudendal Nerve Stimulation in Treating Female Stress Incontinence. ( 26921645 )
2016
6
Tomographic Ultrasound Imaging to Control the Placement of Tension-Free Transobturator Tape in Female Urinary Stress Incontinence. ( 27610378 )
2016
7
Adjustable vs. ordinary transobturator tape for female stress incontinence. Is there a difference? ( 26413335 )
2015
8
Re: Efficacy and safety of polyacrylamide hydrogel for the treatment of female stress incontinence: a randomized, prospective, multicenter North American study. ( 25481730 )
2015
9
Female urinary stress incontinence. ( 26366798 )
2015
10
Efficacy and safety of polyacrylamide hydrogel for the treatment of female stress incontinence: a randomized, prospective, multicenter North American study. ( 24704117 )
2014
11
The first Iraqi experience with the rectus fascia sling and transobturator tape for female stress incontinence: A randomised trial. ( 26019950 )
2014
12
Mini-slings for female urinary stress incontinence: a promising option, but what comes later is not always progress. ( 24035681 )
2014
13
Is antibiotic prophylaxis necessary before midurethral sling procedures for female stress incontinence? A decision analysis. ( 23903818 )
2013
14
Long-term follow-up after urethral injection with polyacrylamide hydrogel for female stress incontinence. ( 24372312 )
2013
15
The autologous fascia pubovaginal sling for complicated female stress incontinence. ( 22396366 )
2012
16
Simultaneous perineal ultrasound and vaginal pressure measurement prove the action of electrical pudendal nerve stimulation in treating female stress incontinence. ( 22417077 )
2012
17
Long-term subjective results of tension-free vaginal tape operation for female urinary stress incontinence. ( 22095550 )
2012
18
How to achieve long-term success in the treatment of female urinary stress incontinence? Novel modification on vaginal sling. ( 21461282 )
2011
19
Transobturator tape for female stress incontinence: follow-up after 24 months. ( 20165575 )
2010
20
Are urodynamics needed before surgery for straightforward female stress incontinence? ( 20961583 )
2010
21
Are urodynamics needed before surgery for straightforward female stress incontinence? ( 20965521 )
2010
22
Two-year comparison of tension-free vaginal tape and transobturator tape for female urinary stress incontinence. ( 20373932 )
2010
23
Recent advances in tape slings for female urinary stress incontinence. ( 19399294 )
2009
24
Transobturator tape in the management of female stress incontinence: clinical outcomes at medium term follow-up. ( 18480630 )
2008
25
Urodynamics in the management of female stress incontinence--which test and when? ( 18520755 )
2008
26
Trans-obturator suburethral tape for female stress incontinence: a cohort of 254 women with 1-year to 2-year follow-up. ( 18231894 )
2008
27
Evaluation and outcome measures in the treatment of female urinary stress incontinence: International Urogynecological Association (IUGA) guidelines for research and clinical practice. ( 18026681 )
2008
28
Transobturator surgery for female stress incontinence: a comparative anatomical study of outside-in vs inside-out techniques. ( 17868425 )
2007
29
MRI urethrovesical junction mobility is associated with global pelvic floor laxity in female stress incontinence. ( 17851825 )
2007
30
A safety and quality of life analysis of intravaginal slingplasty in female stress incontinence: a prospective, open label, multicenter, and observational study. ( 17333435 )
2007
31
Autologous myoblasts and fibroblasts for female stress incontinence: a 1-year follow-up in 123 patients. ( 17760890 )
2007
32
Long-term results of tension-free vaginal tape (TVT) for the treatment of female urinary stress incontinence. ( 16891051 )
2007
33
Monarc transobturator sling system for the treatment of female urinary stress incontinence: results of a post-operative transvaginal ultrasonography. ( 17120171 )
2007
34
Transobturator tape sling for female stress incontinence with polypropylene tape and outside-in procedure: prospective study with 1 year of minimal follow-up and review of transobturator tape sling. ( 17070348 )
2006
35
Dilemmas in the management of female stress incontinence: the role of pelvic floor muscle training. ( 17136582 )
2006
36
A cost-effectiveness analysis of tension-free vaginal tape versus laparoscopic mesh colposuspension for primary female stress incontinence. ( 17260226 )
2006
37
Quality of life after tension-free vaginal tape surgery for female stress incontinence. ( 16608811 )
2006
38
Urethral injections for female stress incontinence. ( 16911598 )
2006
39
Pubovaginal bone anchor fixation with polyethylene versus fascia lata slings in the treatment of female stress incontinence: sling material and processing are predominant factors in success. ( 15877939 )
2005
40
Trans-obturator vaginal tape (TOT) for female stress incontinence: one year follow-up in 120 patients. ( 16182440 )
2005
41
Cost effectiveness of tension-free vaginal tape for the surgical management of female stress incontinence. ( 15609795 )
2004
42
A costed profile audit of the surgical management of female stress incontinence. ( 15648705 )
2004
43
Tension-free vaginal tape and female stress incontinence: further evidence of effectiveness. ( 15153731 )
2004
44
Age-related rhabdosphincter function in female urinary stress incontinence: assessment of intraurethral sonography. ( 15154529 )
2004
45
Anterior urethropexy according to lapides: how effective is it in the treatment of genuine female stress incontinence? ( 12701489 )
2003
46
Are slings now the gold standard treatment for the management of female urinary stress incontinence and if so which technique? ( 12811294 )
2003
47
Safyre: a readjustable minimally invasive sling for female urinary stress incontinence. ( 15745561 )
2003
48
Clinical outcome of fascial slings for female stress incontinence. ( 12142854 )
2002
49
Vesicosuspension for female stress incontinence and cystocele using pubic bone anchors. ( 11820144 )
2001
50
Female stress incontinence. ( 11342928 )
2001

Variations for Female Stress Incontinence

Expression for Female Stress Incontinence

Search GEO for disease gene expression data for Female Stress Incontinence.

Pathways for Female Stress Incontinence

GO Terms for Female Stress Incontinence

Biological processes related to Female Stress Incontinence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adherens junction organization GO:0034332 9.46 ANG PVR
2 drug metabolic process GO:0017144 9.43 CYP1A2 CYP2D6
3 exogenous drug catabolic process GO:0042738 9.4 CYP1A2 CYP2D6
4 long-chain fatty acid biosynthetic process GO:0042759 9.37 CYP1A2 CYP2D6
5 oxidative demethylation GO:0070989 9.32 CYP1A2 CYP2D6
6 heterocycle metabolic process GO:0046483 9.26 CYP1A2 CYP2D6
7 drug catabolic process GO:0042737 9.16 CYP1A2 CYP2D6
8 monoterpenoid metabolic process GO:0016098 8.96 CYP1A2 CYP2D6
9 alkaloid metabolic process GO:0009820 8.62 CYP1A2 CYP2D6

Molecular functions related to Female Stress Incontinence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.43 CYP1A2 CYP2D6 PTGIS
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.37 CYP1A2 CYP2D6
3 iron ion binding GO:0005506 9.33 CYP1A2 CYP2D6 PTGIS
4 aromatase activity GO:0070330 9.32 CYP1A2 CYP2D6
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.13 CYP1A2 CYP2D6 PTGIS
6 monooxygenase activity GO:0004497 8.8 CYP1A2 CYP2D6 PTGIS

Sources for Female Stress Incontinence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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