MCID: FML031
MIFTS: 40

Female Stress Incontinence

Categories: Nephrological diseases

Aliases & Classifications for Female Stress Incontinence

MalaCards integrated aliases for Female Stress Incontinence:

Name: Female Stress Incontinence 38 12 15 73
Female Urinary Stress Incontinence 12
Stress Incontinence - Female 12

Classifications:



External Ids:

Disease Ontology 12 DOID:724
ICD9CM 35 625.6
NCIt 50 C35042
UMLS 73 C0038437

Summaries for Female Stress Incontinence

MalaCards based summary : Female Stress Incontinence, also known as female urinary stress incontinence, is related to vaginitis and urethritis, and has symptoms including unspecified symptom associated with female genital organs, mittelschmerz and pain and other symptoms associated with female genital organs. An important gene associated with Female Stress Incontinence is MEOX2 (Mesenchyme Homeobox 2), and among its related pathways/superpathways are Gefitinib Pathway, Pharmacokinetics and Tamoxifen Pathway, Pharmacokinetics. The drugs Menthol and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include testes and bone, and related phenotype is taste/olfaction.

Related Diseases for Female Stress Incontinence

Diseases related to Female Stress Incontinence via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vaginitis 10.3
2 urethritis 10.1
3 amelogenesis imperfecta, type ib 10.0 CYP1A2 CYP2D6
4 tardive dyskinesia 9.9 CYP1A2 CYP2D6
5 acetaminophen metabolism 9.7 CYP1A2 CYP2D6

Comorbidity relations with Female Stress Incontinence via Phenotypic Disease Network (PDN):


Endometriosis of Uterus Hypothyroidism
Leukoplakia of Vagina Myofibroma
Postmenopausal Atrophic Vaginitis Submucous Uterine Fibroid
Subserous Uterine Fibroid Trigonitis
Urethral Intrinsic Sphincter Deficiency

Graphical network of the top 20 diseases related to Female Stress Incontinence:



Diseases related to Female Stress Incontinence

Symptoms & Phenotypes for Female Stress Incontinence

UMLS symptoms related to Female Stress Incontinence:


unspecified symptom associated with female genital organs, mittelschmerz, pain and other symptoms associated with female genital organs, other specified symptoms associated with female genital organs, female genital pain and other symptoms

MGI Mouse Phenotypes related to Female Stress Incontinence:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.8 MEOX2 SLC6A1 TERT

Drugs & Therapeutics for Female Stress Incontinence

Drugs for Female Stress Incontinence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Not Applicable 2216-51-5 16666
2
Levofloxacin Approved, Investigational 100986-85-4 149096
3
Nitrofurantoin Approved, Vet_approved 67-20-9 5353830
4
Ofloxacin Approved 82419-36-1 4583
5
Sulfamethoxazole Approved 723-46-6 5329
6
Trimethoprim Approved, Vet_approved 738-70-5 5578
7
Silicon Approved, Investigational Not Applicable 7440-21-3 4082203
8 Anesthetics Not Applicable
9 Anti-Bacterial Agents
10 Antibiotics, Antitubercular
11 Trimethoprim, Sulfamethoxazole Drug Combination

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Treatment of Female Stress Urinary Incontinence: Study Comparing Two Suburethral Slings, Retropubic Approach (TVT) and Trans-Obturator (TVT-O) Approach Unknown status NCT00135616 Phase 4
2 A Randomized Controlled Study Comparing Three Single-incision Devices for Female Urinary Stress Incontinence Completed NCT00751088 Phase 4
3 TVTO™ X TVTS ™ for Treatment of Stress Urinary Incontinence Completed NCT01095159 Phase 4
4 TVT-ABBREVO Versus SERASIS for the Treatment of Female Urinary Stress Incontinence: 1 Year Outcomes of a Comparative Study With 2 Trans-obturator Sub Mid Urethral Slings Not yet recruiting NCT02867748 Phase 4
5 Laparoscopic Burch Colposuspension Versus Transobturatory Tape for the Treatment of Female Urinary Stress Incontinence Withdrawn NCT00573703 Phase 4
6 Randomized, Multicenter Trial Comparing TVT With TVT-O for Treatment of Female Urinary Incontinence Unknown status NCT00379314 Phase 3
7 Autologous Rectus Sheath Fascia Versus Midurethral Transobturator Tension Free Vaginal Not yet recruiting NCT03473041 Phase 3
8 Feasibility of Comparing Two Surgical Treatment of Female Urodynamic Stress Completed NCT01230450 Phase 1
9 Lyrette: Renewing Continence Objective and Subjective Efficacy Study Unknown status NCT01455779 Not Applicable
10 The Prefyx PPS™ System eRegistry Unknown status NCT00688181
11 A Comparison of Electrical Pudendal Nerve Stimulation and Pelvic Floor Muscle Training for Female Stress Incontinence Completed NCT01763762 Not Applicable
12 A Feasibility Device Study to Prevent Female Urinary Stress Incontinence Completed NCT03010800 Not Applicable
13 TVT Versus TOT in Urinary Stress Incontinence With No Intrinsic Sphincter Deficiency Completed NCT01903590 Not Applicable
14 Incidence of Symptomatic and Asymptomatic Bacteriuria After Urodynamic Study in Women Completed NCT03106103
15 Continence Pessary Versus Disposable Intravaginal Device Trial Not yet recruiting NCT03174431 Not Applicable
16 Development and Evaluation of a New Diagnostic Test in Female Urinary Stress Incontinence Terminated NCT01563653 Not Applicable
17 Collection of Long Term Patient Outcomes Data Following Implantation of AMS Surgical Devices Terminated NCT01673360

Search NIH Clinical Center for Female Stress Incontinence

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Female Stress Incontinence cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Female Stress Incontinence:
AMDC, autologous muscle-derived cells for urinary incontinence
ICES13, autologous myoblasts for stress urinary incontinence
Embryonic/Adult Cultured Cells Related to Female Stress Incontinence:
Autologous muscle-derived cells PMIDs: 23260547
Muscle-derived myoblasts

Genetic Tests for Female Stress Incontinence

Anatomical Context for Female Stress Incontinence

MalaCards organs/tissues related to Female Stress Incontinence:

41
Testes, Bone

Publications for Female Stress Incontinence

Articles related to Female Stress Incontinence:

(show top 50) (show all 84)
# Title Authors Year
1
The use of polyacrylamide hydrogel in the setting of failed female stress incontinence surgery. ( 29319483 )
2017
2
Is the adjustable TVA mesh effective for the long-term treatment of female stress incontinence? ( 27496772 )
2016
3
Definition of Success after Surgery for Female Stress Incontinence or Voiding Dysfunction: An Attempt at Standardization. ( 28723368 )
2016
4
Efficacy of Electrical Pudendal Nerve Stimulation in Treating Female Stress Incontinence. ( 26921645 )
2016
5
Adjustable vs. ordinary transobturator tape for female stress incontinence. Is there a difference? ( 26413335 )
2015
6
Re: efficacy and safety of polyacrylamide hydrogel for the treatment of female stress incontinence: a randomized, prospective, multicenter north american study: e. R. Sokol, m. M. Karram and R. Dmochowski j urol 2014; 192: 843-849. ( 25481730 )
2015
7
Efficacy and safety of polyacrylamide hydrogel for the treatment of female stress incontinence: a randomized, prospective, multicenter North American study. ( 24704117 )
2014
8
The first Iraqi experience with the rectus fascia sling and transobturator tape for female stress incontinence: A randomised trial. ( 26019950 )
2014
9
Is antibiotic prophylaxis necessary before midurethral sling procedures for female stress incontinence? A decision analysis. ( 23903818 )
2013
10
Long-term follow-up after urethral injection with polyacrylamide hydrogel for female stress incontinence. ( 24372312 )
2013
11
The autologous fascia pubovaginal sling for complicated female stress incontinence. ( 22396366 )
2012
12
Simultaneous perineal ultrasound and vaginal pressure measurement prove the action of electrical pudendal nerve stimulation in treating female stress incontinence. ( 22417077 )
2012
13
Transobturator tape for female stress incontinence: follow-up after 24 months. ( 20165575 )
2010
14
Are urodynamics needed before surgery for straightforward female stress incontinence? ( 20961583 )
2010
15
Are urodynamics needed before surgery for straightforward female stress incontinence? ( 20965521 )
2010
16
Transobturator tape in the management of female stress incontinence: clinical outcomes at medium term follow-up. ( 18480630 )
2008
17
Urodynamics in the management of female stress incontinence--which test and when? ( 18520755 )
2008
18
Trans-obturator suburethral tape for female stress incontinence: a cohort of 254 women with 1-year to 2-year follow-up. ( 18231894 )
2008
19
Transobturator surgery for female stress incontinence: a comparative anatomical study of outside-in vs inside-out techniques. ( 17868425 )
2007
20
MRI urethrovesical junction mobility is associated with global pelvic floor laxity in female stress incontinence. ( 17851825 )
2007
21
A safety and quality of life analysis of intravaginal slingplasty in female stress incontinence: a prospective, open label, multicenter, and observational study. ( 17333435 )
2007
22
Autologous myoblasts and fibroblasts for female stress incontinence: a 1-year follow-up in 123 patients. ( 17760890 )
2007
23
Transobturator tape sling for female stress incontinence with polypropylene tape and outside-in procedure: prospective study with 1 year of minimal follow-up and review of transobturator tape sling. ( 17070348 )
2006
24
Dilemmas in the management of female stress incontinence: the role of pelvic floor muscle training. ( 17136582 )
2006
25
A cost-effectiveness analysis of tension-free vaginal tape versus laparoscopic mesh colposuspension for primary female stress incontinence. ( 17260226 )
2006
26
Quality of life after tension-free vaginal tape surgery for female stress incontinence. ( 16608811 )
2006
27
Urethral injections for female stress incontinence. ( 16911598 )
2006
28
Pubovaginal bone anchor fixation with polyethylene versus fascia lata slings in the treatment of female stress incontinence: sling material and processing are predominant factors in success. ( 15877939 )
2005
29
Trans-obturator vaginal tape (TOT) for female stress incontinence: one year follow-up in 120 patients. ( 16182440 )
2005
30
Cost effectiveness of tension-free vaginal tape for the surgical management of female stress incontinence. ( 15609795 )
2004
31
A costed profile audit of the surgical management of female stress incontinence. ( 15648705 )
2004
32
Tension-free vaginal tape and female stress incontinence: further evidence of effectiveness. ( 15153731 )
2004
33
Anterior urethropexy according to lapides: how effective is it in the treatment of genuine female stress incontinence? ( 12701489 )
2003
34
Clinical outcome of fascial slings for female stress incontinence. ( 12142854 )
2002
35
Vesicosuspension for female stress incontinence and cystocele using pubic bone anchors. ( 11820144 )
2001
36
Female stress incontinence. ( 11342928 )
2001
37
Inguinovaginal sling procedure for female stress incontinence: introduction of a minimally invasive technique. ( 11383987 )
2001
38
The thimble: a useful adjunct to needle suspension procedures for female stress incontinence. ( 11113759 )
2000
39
A urinary control device for management of female stress incontinence. ( 10711555 )
2000
40
beta(2)-adrenergic agonists and pelvic floor exercises for female stress incontinence. ( 11044540 )
2000
41
Effectiveness of the conveen continence guard (a disposable vaginal device) in the treatment of complicated female stress incontinence. ( 11130086 )
2000
42
Outcome results of transurethral collagen injection for female stress incontinence: assessment by urinary incontinence score. ( 11061903 )
2000
43
Tension-free vaginal tape (TVT) - a new surgical procedure for female stress incontinence. ( 15512507 )
2000
44
Minimally invasive pervaginam procedures for the treatment of female stress incontinence using a new pubic bone anchoring system. ( 9790087 )
1998
45
Transurethral collagen injection for female stress incontinence. ( 9657173 )
1998
46
Clinical value of vaginal cones for the management of female stress incontinence. ( 9557998 )
1997
47
Bladder neck suspension using bone anchors for the treatment of female stress incontinence. ( 9152492 )
1997
48
Incisionless per vaginal bone anchor cystourethropexy for the treatment of female stress incontinence: experience with the first 50 patients. ( 9334591 )
1997
49
Long-term efficacy and safety of a disposable vaginal device (continence guard) in the treatment of female stress incontinence. ( 9449583 )
1997
50
Voiding cystourethrography in female stress incontinence. ( 8819416 )
1996

Variations for Female Stress Incontinence

Expression for Female Stress Incontinence

Search GEO for disease gene expression data for Female Stress Incontinence.

Pathways for Female Stress Incontinence

GO Terms for Female Stress Incontinence

Biological processes related to Female Stress Incontinence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug metabolic process GO:0017144 9.4 CYP1A2 CYP2D6
2 exogenous drug catabolic process GO:0042738 9.37 CYP1A2 CYP2D6
3 oxidative demethylation GO:0070989 9.32 CYP1A2 CYP2D6
4 heterocycle metabolic process GO:0046483 9.26 CYP1A2 CYP2D6
5 drug catabolic process GO:0042737 9.16 CYP1A2 CYP2D6
6 monoterpenoid metabolic process GO:0016098 8.96 CYP1A2 CYP2D6
7 alkaloid metabolic process GO:0009820 8.62 CYP1A2 CYP2D6

Molecular functions related to Female Stress Incontinence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.43 CYP1A2 CYP2D6 PTGIS
2 oxygen binding GO:0019825 9.4 CYP1A2 CYP2D6
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.37 CYP1A2 CYP2D6
4 heme binding GO:0020037 9.33 CYP1A2 CYP2D6 PTGIS
5 aromatase activity GO:0070330 9.32 CYP1A2 CYP2D6
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.13 CYP1A2 CYP2D6 PTGIS
7 monooxygenase activity GO:0004497 8.8 CYP1A2 CYP2D6 PTGIS

Sources for Female Stress Incontinence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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