MCID: FMR002
MIFTS: 27

Femoral Cancer

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Femoral Cancer

MalaCards integrated aliases for Femoral Cancer:

Name: Femoral Cancer 12 15 17
Femoral Neoplasms 44 71
Neoplasm of Femur 12
Femoral Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5546
MeSH 44 D005266
SNOMED-CT 67 126583006
UMLS 71 C0015807

Summaries for Femoral Cancer

Disease Ontology : 12 A bone cancer that is located in the femur.

MalaCards based summary : Femoral Cancer, also known as femoral neoplasms, is related to low compliance bladder and tuberculum sellae meningioma. An important gene associated with Femoral Cancer is P2RX3 (Purinergic Receptor P2X 3), and among its related pathways/superpathways are PEDF Induced Signaling and PAK Pathway. Affiliated tissues include femur, and related phenotypes are behavior/neurological and integument

Related Diseases for Femoral Cancer

Diseases related to Femoral Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 low compliance bladder 10.3 P2RX3 NGF
2 tuberculum sellae meningioma 10.2 TCF21 EDNRA
3 sella turcica neoplasm 10.2 TCF21 EDNRA
4 benign struma ovarii 10.2 TCF21 NTRK1
5 neuropathy, hereditary sensory and autonomic, type v 10.2 NTRK1 NGF
6 neuropathy, hereditary sensory and autonomic, type viii 10.2 NTRK1 NGF
7 neurodermatitis 10.2 TAC1 MRGPRD
8 ocular cicatricial pemphigoid 10.2 NTRK1 NGF
9 reflex sympathetic dystrophy 10.2 TAC1 P2RX3
10 decubitus ulcer 10.2 NGF ASIC3
11 retrograde amnesia 10.1 PDYN FOS
12 paralytic ileus 10.1 TCF21 TAC1
13 algoneurodystrophy 10.1 TAC1 NGF
14 punctate epithelial keratoconjunctivitis 10.1 TAC1 NGF
15 mononeuropathy 10.0 TAC1 NGF
16 patulous eustachian tube 10.0 FOS CCL11
17 causalgia 10.0 TAC1 P2RX3 NGF
18 detrusor sphincter dyssynergia 10.0 TAC1 P2RX3 NGF
19 chronic cystitis 10.0 TAC1 P2RX3 NGF
20 cystitis 10.0 TAC1 P2RX3 NGF
21 burning mouth syndrome 10.0 TAC1 P2RX3 NGF
22 neurogenic bladder 10.0 TAC1 P2RX3 NGF
23 myofascial pain syndrome 10.0 TAC1 NGF ASIC3
24 somatoform disorder 10.0 TAC1 P2RX3 NGF
25 urethral syndrome 10.0 TAC1 P2RX3 NGF
26 osteopetrosis, autosomal recessive 2 10.0 TNFSF11 ACP5
27 interstitial cystitis 10.0 TAC1 P2RX3 NGF
28 tendinitis 10.0 TAC1 ACP5
29 osteopetrosis, autosomal dominant 2 10.0 TNFSF11 ACP5
30 amnestic disorder 10.0 PDYN NGF FOS
31 periapical periodontitis 10.0 TNFSF11 ACP5
32 opiate dependence 10.0 PDYN NGF FOS
33 neurogenic arthropathy 10.0 TAC1 NTRK1 NGF
34 tooth resorption 10.0 TNFSF11 ACP5
35 motion sickness 10.0 TAC1 FOS
36 malignant renovascular hypertension 9.9 EDNRA EDN1
37 acquired color blindness 9.9 EDNRA EDN1
38 perinephritis 9.9 EDNRA EDN1
39 mandibulofacial dysostosis with alopecia 9.9 EDNRA EDN1
40 morphine dependence 9.9 PDYN FOS
41 anhidrosis, isolated, with normal sweat glands 9.9 EDNRA EDN1
42 malignant secondary hypertension 9.9 EDNRA EDN1
43 nephrogenic systemic fibrosis 9.9 EDNRA EDN1
44 osteopetrosis, autosomal recessive 8 9.9 TNFSF11 ACP5
45 corneal ulcer 9.9 TAC1 NGF CCL11
46 raynaud disease 9.9 EDNRA EDN1
47 bone benign neoplasm 9.9 TNFSF11 ACP5
48 pigmented villonodular synovitis 9.8 TNFSF11 ACP5
49 chronic pulmonary heart disease 9.8 EDNRA EDN1
50 nerve compression syndrome 9.8 TNFSF11 TAC1 NGF

Graphical network of the top 20 diseases related to Femoral Cancer:



Diseases related to Femoral Cancer

Symptoms & Phenotypes for Femoral Cancer

MGI Mouse Phenotypes related to Femoral Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ASIC3 EDNRA FOS MRGPRD NGF NTRK1
2 integument MP:0010771 10 ASIC3 EDNRA FOS MRGPRD NGF NTRK1
3 muscle MP:0005369 9.7 EDN1 EDNRA MRGPRD NGF NTRK1 TCF21
4 nervous system MP:0003631 9.61 ASIC3 EDN1 EDNRA FOS MRGPRD NGF
5 normal MP:0002873 9.32 CCL11 EDN1 EDNRA FOS MRGPRD NGF

Drugs & Therapeutics for Femoral Cancer

Search Clinical Trials , NIH Clinical Center for Femoral Cancer

Cochrane evidence based reviews: femoral neoplasms

Genetic Tests for Femoral Cancer

Anatomical Context for Femoral Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Femoral Cancer:

19
Femur

Publications for Femoral Cancer

Articles related to Femoral Cancer:

# Title Authors PMID Year
1
Loading comparison of two structures in the moving tube of a non-invasive prosthesis. 61
33492253 2021

Variations for Femoral Cancer

Expression for Femoral Cancer

Search GEO for disease gene expression data for Femoral Cancer.

Pathways for Femoral Cancer

Pathways related to Femoral Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 TNFSF11 NTRK1 NGF FOS EDNRA EDN1
2
Show member pathways
12.95 TNFSF11 TCF21 NTRK1 NGF FOS CCL11
3 11.84 P2RX3 NTRK1 NGF EDNRA
4 11.81 NTRK1 NGF FOS
5 11.74 TNFSF11 FOS ACP5
6
Show member pathways
11.69 NTRK1 NGF FOS EDNRA EDN1 ASIC3
7 11.47 TNFSF11 FOS ACP5
8
Show member pathways
10.94 EDNRA EDN1
9 10.91 FOS EDN1
10 10.86 FOS EDNRA EDN1
11 10.64 TNFSF11 ACP5
12 10.56 TNFSF11 NTRK1 NGF FOS CCL11
13
Show member pathways
10.41 NTRK1 NGF

GO Terms for Femoral Cancer

Cellular components related to Femoral Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.26 TAC1 P2RX3 NTRK1 NGF
2 neuronal cell body GO:0043025 8.92 TAC1 PDYN P2RX3 NTRK1

Biological processes related to Femoral Cancer according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.93 TAC1 PDYN MRGPRD EDNRA EDN1 CCL11
2 response to hypoxia GO:0001666 9.78 P2RX3 EDNRA EDN1
3 response to lipopolysaccharide GO:0032496 9.77 TAC1 FOS EDN1
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.76 TAC1 EDNRA EDN1
5 neural crest cell development GO:0014032 9.59 EDNRA EDN1
6 bone resorption GO:0045453 9.58 TNFSF11 ACP5
7 positive regulation of osteoclast differentiation GO:0045672 9.57 TNFSF11 FOS
8 neurotrophin TRK receptor signaling pathway GO:0048011 9.56 NTRK1 NGF
9 vasoconstriction GO:0042310 9.55 EDNRA EDN1
10 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.54 NTRK1 ASIC3
11 response to muscle stretch GO:0035994 9.52 FOS EDN1
12 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.51 NTRK1 ASIC3
13 positive regulation of renal sodium excretion GO:0035815 9.49 TAC1 EDN1
14 sensory perception GO:0007600 9.48 PDYN ASIC3
15 nerve growth factor signaling pathway GO:0038180 9.43 NTRK1 NGF
16 regulation of blood pressure GO:0008217 9.43 TAC1 EDNRA EDN1
17 artery smooth muscle contraction GO:0014824 9.4 EDNRA EDN1
18 regulation of glucose transmembrane transport GO:0010827 9.37 EDNRA EDN1
19 response to mechanical stimulus GO:0009612 9.33 P2RX3 FOS ASIC3
20 endothelin receptor signaling pathway GO:0086100 9.32 EDNRA EDN1
21 sensory perception of pain GO:0019233 9.13 TAC1 NTRK1 EDN1
22 behavioral response to formalin induced pain GO:0061368 8.62 P2RX3 NTRK1

Sources for Femoral Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....