Femoral Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Femoral Cancer

MalaCards integrated aliases for Femoral Cancer:

Name: Femoral Cancer ¹² ¹⁵ ¹⁷

Femoral Neoplasms ⁴⁴ ⁷¹

Neoplasm of Femur ¹²

Femoral Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5546

MeSH ⁴⁴ D005266

SNOMED-CT ⁶⁷ 126583006

EFO ¹⁷ EFO_0007270

UMLS ⁷¹ C0015807

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Summaries for Femoral Cancer

Disease Ontology : ¹² A bone cancer that is located in the femur.

MalaCards based summary : Femoral Cancer, also known as femoral neoplasms, is related to low compliance bladder and tuberculum sellae meningioma. An important gene associated with Femoral Cancer is P2RX3 (Purinergic Receptor P2X 3), and among its related pathways/superpathways are PEDF Induced Signaling and PAK Pathway. Affiliated tissues include femur, and related phenotypes are behavior/neurological and integument

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Related Diseases for Femoral Cancer

Diseases related to Femoral Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)

#	Related Disease	Score	Top Affiliating Genes
1	low compliance bladder	10.3	P2RX3 NGF
2	tuberculum sellae meningioma	10.2	TCF21 EDNRA
3	sella turcica neoplasm	10.2	TCF21 EDNRA
4	benign struma ovarii	10.2	TCF21 NTRK1
5	neuropathy, hereditary sensory and autonomic, type v	10.2	NTRK1 NGF
6	neuropathy, hereditary sensory and autonomic, type viii	10.2	NTRK1 NGF
7	neurodermatitis	10.2	TAC1 MRGPRD
8	ocular cicatricial pemphigoid	10.2	NTRK1 NGF
9	reflex sympathetic dystrophy	10.2	TAC1 P2RX3
10	decubitus ulcer	10.2	NGF ASIC3
11	retrograde amnesia	10.1	PDYN FOS
12	paralytic ileus	10.1	TCF21 TAC1
13	algoneurodystrophy	10.1	TAC1 NGF
14	punctate epithelial keratoconjunctivitis	10.1	TAC1 NGF
15	mononeuropathy	10.0	TAC1 NGF
16	patulous eustachian tube	10.0	FOS CCL11
17	causalgia	10.0	TAC1 P2RX3 NGF
18	detrusor sphincter dyssynergia	10.0	TAC1 P2RX3 NGF
19	chronic cystitis	10.0	TAC1 P2RX3 NGF
20	cystitis	10.0	TAC1 P2RX3 NGF
21	burning mouth syndrome	10.0	TAC1 P2RX3 NGF
22	neurogenic bladder	10.0	TAC1 P2RX3 NGF
23	myofascial pain syndrome	10.0	TAC1 NGF ASIC3
24	somatoform disorder	10.0	TAC1 P2RX3 NGF
25	urethral syndrome	10.0	TAC1 P2RX3 NGF
26	osteopetrosis, autosomal recessive 2	10.0	TNFSF11 ACP5
27	interstitial cystitis	10.0	TAC1 P2RX3 NGF
28	tendinitis	10.0	TAC1 ACP5
29	osteopetrosis, autosomal dominant 2	10.0	TNFSF11 ACP5
30	amnestic disorder	10.0	PDYN NGF FOS
31	periapical periodontitis	10.0	TNFSF11 ACP5
32	opiate dependence	10.0	PDYN NGF FOS
33	neurogenic arthropathy	10.0	TAC1 NTRK1 NGF
34	tooth resorption	10.0	TNFSF11 ACP5
35	motion sickness	10.0	TAC1 FOS
36	malignant renovascular hypertension	9.9	EDNRA EDN1
37	acquired color blindness	9.9	EDNRA EDN1
38	perinephritis	9.9	EDNRA EDN1
39	mandibulofacial dysostosis with alopecia	9.9	EDNRA EDN1
40	morphine dependence	9.9	PDYN FOS
41	anhidrosis, isolated, with normal sweat glands	9.9	EDNRA EDN1
42	malignant secondary hypertension	9.9	EDNRA EDN1
43	nephrogenic systemic fibrosis	9.9	EDNRA EDN1
44	osteopetrosis, autosomal recessive 8	9.9	TNFSF11 ACP5
45	corneal ulcer	9.9	TAC1 NGF CCL11
46	raynaud disease	9.9	EDNRA EDN1
47	bone benign neoplasm	9.9	TNFSF11 ACP5
48	pigmented villonodular synovitis	9.8	TNFSF11 ACP5
49	chronic pulmonary heart disease	9.8	EDNRA EDN1
50	nerve compression syndrome	9.8	TNFSF11 TAC1 NGF

Graphical network of the top 20 diseases related to Femoral Cancer:

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Symptoms & Phenotypes for Femoral Cancer

MGI Mouse Phenotypes related to Femoral Cancer:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.02	ASIC3 EDNRA FOS MRGPRD NGF NTRK1
2	integument	MP:0010771	10	ASIC3 EDNRA FOS MRGPRD NGF NTRK1
3	muscle	MP:0005369	9.7	EDN1 EDNRA MRGPRD NGF NTRK1 TCF21
4	nervous system	MP:0003631	9.61	ASIC3 EDN1 EDNRA FOS MRGPRD NGF
5	normal	MP:0002873	9.32	CCL11 EDN1 EDNRA FOS MRGPRD NGF

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Drugs & Therapeutics for Femoral Cancer

Search Clinical Trials , NIH Clinical Center for Femoral Cancer

Cochrane evidence based reviews: femoral neoplasms

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Genetic Tests for Femoral Cancer

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Anatomical Context for Femoral Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Femoral Cancer:

¹⁹

Femur

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Publications for Femoral Cancer

Articles related to Femoral Cancer:

#	Title	Authors	PMID	Year
1	Loading comparison of two structures in the moving tube of a non-invasive prosthesis. ⁶¹	Zhang J...Chang Z	33492253	2021

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Genes for Femoral Cancer

Genes related to Femoral Cancer (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	P2RX3	Purinergic Receptor P2X 3	Protein Coding	5.58	DISEASES inferred ¹⁵
2	MRGPRD	MAS Related GPR Family Member D	Protein Coding	5.54	DISEASES inferred ¹⁵
3	ASIC3	Acid Sensing Ion Channel Subunit 3	Protein Coding	5.07	DISEASES inferred ¹⁵
4	PDYN	Prodynorphin	Protein Coding	4.37	DISEASES inferred ¹⁵
5	TCF21	Transcription Factor 21	Protein Coding	4.36	DISEASES inferred ¹⁵
6	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	4.29	DISEASES inferred ¹⁵
7	NGF	Nerve Growth Factor	Protein Coding	4.16	DISEASES inferred ¹⁵
8	EDNRA	Endothelin Receptor Type A	Protein Coding	4.12	DISEASES inferred ¹⁵
9	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	3.95	DISEASES inferred ¹⁵
10	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	3.77	DISEASES inferred ¹⁵
11	TAC1	Tachykinin Precursor 1	Protein Coding	3.52	DISEASES inferred ¹⁵
12	TNFSF11	TNF Superfamily Member 11	Protein Coding	3.35	DISEASES inferred ¹⁵
13	EDN1	Endothelin 1	Protein Coding	3.31	DISEASES inferred ¹⁵
14	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3.23	DISEASES inferred ¹⁵

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Variations for Femoral Cancer

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Expression for Femoral Cancer

Search GEO for disease gene expression data for Femoral Cancer.

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Pathways for Femoral Cancer

Pathways related to Femoral Cancer according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.38	TNFSF11 NTRK1 NGF FOS EDNRA EDN1
2	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.95	TNFSF11 TCF21 NTRK1 NGF FOS CCL11
3	Calcium signaling pathway ³⁶	11.84	P2RX3 NTRK1 NGF EDNRA
4	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway ¹	11.81	NTRK1 NGF FOS
5	Osteoclast differentiation ³⁶	11.74	TNFSF11 FOS ACP5
6	Development Endothelin-1/EDNRA signaling ²³ Show member pathways Cytoskeleton remodeling FAK signaling ²³ Development Endothelin-1/EDNRA transactivation of EGFR ²³ GnRH signaling pathway ³⁶ Inflammatory mediator regulation of TRP channels ³⁶	11.69	NTRK1 NGF FOS EDNRA EDN1 ASIC3
7	Rheumatoid arthritis ³⁶	11.47	TNFSF11 FOS ACP5
8	EGFR Transactivation by Gastrin ⁶⁵ Show member pathways EGFR-dependent Endothelin signaling events ¹ SHC-related events triggered by IGF1R ⁶⁵	10.94	EDNRA EDN1
9	Physiological and Pathological Hypertrophy of the Heart ¹	10.91	FOS EDN1
10	Endothelins ¹	10.86	FOS EDNRA EDN1
11	Osteoclast Signaling ¹	10.64	TNFSF11 ACP5
12	G-protein signaling_Rap2B regulation pathway ²³	10.56	TNFSF11 NTRK1 NGF FOS CCL11
13	Activation of TRKA receptors ⁶⁵ Show member pathways NGF-independant TRKA activation ⁶⁵	10.41	NTRK1 NGF

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GO Terms for Femoral Cancer

Cellular components related to Femoral Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:0030424	9.26	TAC1 P2RX3 NTRK1 NGF
2	neuronal cell body	GO:0043025	8.92	TAC1 PDYN P2RX3 NTRK1

Biological processes related to Femoral Cancer according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor signaling pathway	GO:0007186	9.93	TAC1 PDYN MRGPRD EDNRA EDN1 CCL11
2	response to hypoxia	GO:0001666	9.78	P2RX3 EDNRA EDN1
3	response to lipopolysaccharide	GO:0032496	9.77	TAC1 FOS EDN1
4	positive regulation of cytosolic calcium ion concentration	GO:0007204	9.76	TAC1 EDNRA EDN1
5	neural crest cell development	GO:0014032	9.59	EDNRA EDN1
6	bone resorption	GO:0045453	9.58	TNFSF11 ACP5
7	positive regulation of osteoclast differentiation	GO:0045672	9.57	TNFSF11 FOS
8	neurotrophin TRK receptor signaling pathway	GO:0048011	9.56	NTRK1 NGF
9	vasoconstriction	GO:0042310	9.55	EDNRA EDN1
10	detection of temperature stimulus involved in sensory perception of pain	GO:0050965	9.54	NTRK1 ASIC3
11	response to muscle stretch	GO:0035994	9.52	FOS EDN1
12	detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	9.51	NTRK1 ASIC3
13	positive regulation of renal sodium excretion	GO:0035815	9.49	TAC1 EDN1
14	sensory perception	GO:0007600	9.48	PDYN ASIC3
15	nerve growth factor signaling pathway	GO:0038180	9.43	NTRK1 NGF
16	regulation of blood pressure	GO:0008217	9.43	TAC1 EDNRA EDN1
17	artery smooth muscle contraction	GO:0014824	9.4	EDNRA EDN1
18	regulation of glucose transmembrane transport	GO:0010827	9.37	EDNRA EDN1
19	response to mechanical stimulus	GO:0009612	9.33	P2RX3 FOS ASIC3
20	endothelin receptor signaling pathway	GO:0086100	9.32	EDNRA EDN1
21	sensory perception of pain	GO:0019233	9.13	TAC1 NTRK1 EDN1
22	behavioral response to formalin induced pain	GO:0061368	8.62	P2RX3 NTRK1

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Sources for Femoral Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia