Fetal Akinesia Deformation Sequence 2 (FADS2)

Categories: Fetal diseases, Genetic diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Fetal Akinesia Deformation Sequence 2

MalaCards integrated aliases for Fetal Akinesia Deformation Sequence 2:

Name: Fetal Akinesia Deformation Sequence 2 56 73 29 6
Fads2 56 12 73
Fetal Akinesia Deformation Sequence Syndrome 2 12



autosomal recessive


External Ids:

Disease Ontology 12 DOID:0111378
OMIM 56 618388
OMIM Phenotypic Series 56 PS208150
MedGen 41 CN258279

Summaries for Fetal Akinesia Deformation Sequence 2

OMIM : 56 The fetal akinesia deformation sequence (FADS) refers to a clinically and genetically heterogeneous constellation of features including fetal akinesia, intrauterine growth retardation, arthrogryposis, and developmental anomalies, including lung hypoplasia, cleft palate, and cryptorchidism (Vogt et al., 2009). It shows phenotypic overlap with the lethal form of multiple pterygium syndrome (see 253290). For a general phenotypic description and a discussion of genetic heterogeneity of FADS, see 208150. (618388)

MalaCards based summary : Fetal Akinesia Deformation Sequence 2, also known as fads2, is related to fetal akinesia deformation sequence 4 and attention deficit-hyperactivity disorder. An important gene associated with Fetal Akinesia Deformation Sequence 2 is RAPSN (Receptor Associated Protein Of The Synapse). The drugs Olive and Fat Emulsions, Intravenous have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain.

Disease Ontology : 12 A fetal akinesia deformation sequence that has material basis in homozygous or compound heterozygous mutation in RAPSN on chromosome 11p11.2.

UniProtKB/Swiss-Prot : 73 Fetal akinesia deformation sequence 2: A clinically and genetically heterogeneous group of disorders with congenital malformations related to impaired fetal movement. Clinical features include fetal akinesia, intrauterine growth retardation, polyhydramnios, arthrogryposis, pulmonary hypoplasia, craniofacial abnormalities, and cryptorchidism. FADS2 inheritance is autosomal recessive.

Related Diseases for Fetal Akinesia Deformation Sequence 2

Graphical network of the top 20 diseases related to Fetal Akinesia Deformation Sequence 2:

Diseases related to Fetal Akinesia Deformation Sequence 2

Symptoms & Phenotypes for Fetal Akinesia Deformation Sequence 2

Symptoms via clinical synopsis from OMIM:

Head And Neck Eyes:
downslanting palpebral fissures

Head And Neck Mouth:
cleft palate
high-arched palate
small mouth
thin lips

Head And Neck Face:
short philtrum
flat facial profile

Prenatal Manifestations:
fetal akinesia sequence
hydrops fetalis (mild)

respiratory distress

Skeletal Limbs:
joint contractures
abnormally flexed elbows

Abdomen Gastrointestinal:
feeding problems

Prenatal Manifestations Movement:
decreased fetal movements

Head And Neck Neck:
short, broad neck

Skeletal Feet:
hyperextended toes

Head And Neck Nose:
wide nasal bridge
short nose

Genitourinary Internal Genitalia Male:

Head And Neck Ears:
low-set ears

weak cry

Neurologic Central Nervous System:

Chest External Features:
small thorax

Respiratory Lung:
hypoplastic lungs

Skeletal Hands:
flexed fingers
wrist hyperextension

Chest Diaphragm:
thin diaphragm

Clinical features from OMIM:


Drugs & Therapeutics for Fetal Akinesia Deformation Sequence 2

Drugs for Fetal Akinesia Deformation Sequence 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 13, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Olive Phase 4
2 Fat Emulsions, Intravenous Phase 4
3 Soybean oil, phospholipid emulsion Phase 4
4 Soy Bean Phase 4
5 Parenteral Nutrition Solutions Phase 4
6 Pharmaceutical Solutions Phase 4
7 Phytosterol Phase 4
8 Liver Extracts Phase 4
9 Nutrients
10 Linoleate
11 Sunflower
12 Flax
13 Omega 3 Fatty Acid

Interventional clinical trials:

(showing 6, show less)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Controlled, Clinical Trial to Evaluate the Risk of Developing Essential Fatty Acid Deficiency in Pediatric Patients, Including Neonates, Receiving Either Clinolipid (Lipid Injectable Emulsion, USP) 20% or Standard-of-Care Soybean Oil-Based Lipid Emulsion Terminated NCT02476994 Phase 4 Clinolipid;Intralipid
2 The Influence of FADS2 rs 174575 on Breastmilk Fatty Acid Levels and the Recognition Memory Abilities of 6-month Old Breastfed Infants and Follow-up Completed NCT01942434
3 The Role of Fillagrin Gene Mutations and FADS Genes Variation Through Its Effect on the Concentration of Polyunsaturated Fatty Acids Towards the Occurance of Atopic Dermatitis in Indonesian Infants Completed NCT02401178
4 Fatty Acid Desaturase Gene Locus Interactions With Diet (FADSDIET2) Completed NCT03572205
5 Canola and Flax Oils in Modulation of Vascular Function and Biomarkers of Cardiovascular Disease Risk Completed NCT01351012
6 The Effect of Alpha Linolenic Acid (ALA) Supplementation on Essential Fatty Acids Profile During Pregnancy Compared to Common Supplements and the Epigenetic Effect on the Newborn Not yet recruiting NCT03040856

Search NIH Clinical Center for Fetal Akinesia Deformation Sequence 2

Genetic Tests for Fetal Akinesia Deformation Sequence 2

Genetic tests related to Fetal Akinesia Deformation Sequence 2:

# Genetic test Affiliating Genes
1 Fetal Akinesia Deformation Sequence 2 29

Anatomical Context for Fetal Akinesia Deformation Sequence 2

MalaCards organs/tissues related to Fetal Akinesia Deformation Sequence 2:

Liver, Lung, Brain, Breast, Heart, Cortex, Adipocyte

Publications for Fetal Akinesia Deformation Sequence 2

Articles related to Fetal Akinesia Deformation Sequence 2:

(showing 479, show less)
# Title Authors PMID Year
Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders. 56 6
18252226 2008
Mutation analysis of CHRNA1, CHRNB1, CHRND, and RAPSN genes in multiple pterygium syndrome/fetal akinesia patients. 56 6
18179903 2008
Germline mutation in DOK7 associated with fetal akinesia deformation sequence. 56
19261599 2009
Rapsyn mutations in hereditary myasthenia: distinct early- and late-onset phenotypes. 6
14504330 2003
PCTR1 ameliorates lipopolysaccharide-induced acute inflammation and multiple organ damage via regulation of linoleic acid metabolism by promoting FADS1/FASDS2/ELOV2 expression and reducing PLA2 expression. 61
32123295 2020
Limited Evidence for Selection at the FADS Locus in Native American Populations. 61
32145021 2020
Fatty acid induced lipolysis influences embryo development, gene expression and lipid droplet formation in the porcine cumulus cells†. 61
32318713 2020
Whole Blood DNA Methylation Signatures of Diet Are Associated with Cardiovascular Disease Risk Factors and All-cause Mortality. 61
32525743 2020
Region-specific changes in the mRNA and protein expression of LCPUFA biosynthesis enzymes and transporters in the placentae of women with preeclampsia. 61
32452400 2020
FADS1 (Fatty Acid Desaturase 1) Genotype Associates With Aortic Valve FADS mRNA Expression, Fatty Acid Content and Calcification. 61
32397743 2020
Transcription factor pparαb activates fads2s to promote LC-PUFA biosynthesis in the golden pompano Trachinotus ovatus (Linnaeus 1758). 61
32535207 2020
Expression of enzymes involved in polyunsaturated fatty acid synthesis in the stallion testis and epididymis. 61
32527375 2020
Huang-Qi San improves glucose and lipid metabolism and exerts protective effects against hepatic steatosis in high fat diet-fed rats. 61
32114355 2020
Transcriptional regulation mechanism of SREBP on Δ6 Fad in razor clam Sinonovacula constricta. 61
32517818 2020
Comparative and functional analysis of desaturase FADS1 (∆5) and FADS2 (∆6) orthologues of marine organisms. 61
32554222 2020
Dietary ω3-and ω6-Polyunsaturated fatty acids reconstitute fertility of Juvenile and adult Fads2-Deficient mice. 61
32272092 2020
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway. 61
32432943 2020
Disturbance of Fatty Acid Desaturation Mediated by FADS2 in Mesenteric Adipocytes Contributes to Chronic Inflammation of Crohn's Disease. 61
32365195 2020
Risk SNP-Mediated Enhancer-Promoter Interaction Drives Colorectal Cancer through Both FADS2 and AP002754.2. 61
32127356 2020
Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme. 61
32392704 2020
Stearoyl-CoA desaturase (scd1a) is epigenetically regulated by broodstock nutrition in gilthead sea bream (Sparus aurata). 61
31790638 2020
The miR-15/16 Cluster Is Involved in the Regulation of Vertebrate LC-PUFA Biosynthesis by Targeting pparγ as Demonostrated in Rabbitfish Siganus canaliculatus. 61
32418070 2020
Maternal Long-Chain Polyunsaturated Fatty Acid Status, Methylmercury Exposure, and Birth Outcomes in a High-Fish-Eating Mother-Child Cohort. 61
32433731 2020
High-throughput transcriptome and pathogenesis analysis of clinical psoriasis. 61
32381429 2020
Effects of dietary incorporation of linseed oil with soybean isoflavone on fatty acid profiles and lipid metabolism-related gene expression in breast muscle of chickens. 61
32423522 2020
Fatty acid desaturation in red blood cell membranes of patients with type 2 diabetes is improved by zinc supplementation. 61
32534376 2020
CRISPR/Cas9 Based Knockout of miR-145 Affects Intracellular Fatty Acid Metabolism by Targeting INSIG1 in Goat Mammary Epithelial Cells. 61
32299216 2020
Genes controlling polyunsaturated fatty acid synthesis are developmentally regulated in broiler chicks. 61
32316746 2020
Polymorphisms in Fatty Acid Desaturase 2 Gene are Associated with Milk Production Traits in Chinese Holstein Cows. 61
32290630 2020
Functional characterisation of fatty acyl desaturase, Fads2, and elongase, Elovl5, in the Boddart's goggle-eyed goby Boleophthalmus boddarti (Gobiidae) suggests an incapacity for long-chain polyunsaturated fatty acid biosynthesis. 61
32222967 2020
Fatty acid desaturase 2 (FADS2) but not FADS1 desaturates branched chain and odd chain saturated fatty acids. 61
31751799 2020
Multi-omics Data Integration for Identifying Osteoporosis Biomarkers and Their Biological Interaction and Causal Mechanisms. 61
32058959 2020
A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia. 61
32107650 2020
Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific. 61
32031713 2020
Integrated metabolomic and transcriptomic analyses identify critical genes in eicosapentaenoic acid biosynthesis and metabolism in the sea urchin Strongylocentrotus intermedius. 61
32015446 2020
Differential Regulation of circRNA, miRNA, and piRNA during Early Osteogenic and Chondrogenic Differentiation of Human Mesenchymal Stromal Cells. 61
32050423 2020
Molecular and functional characterisation of a putative elovl4 gene and its expression in response to dietary fatty acid profile in Atlantic bluefin tuna (Thunnus thynnus). 61
31669375 2020
Comparative Transcriptome Analysis Provides Insights into the Polyunsaturated Fatty Acid Synthesis Regulation of Fat-1 Transgenic Sheep. 61
32046209 2020
A comparative metabolomics study on anadromous clupeid Tenualosa ilisha for better understanding the influence of habitat on nutritional composition. 61
32100135 2020
Improvement on metabolic syndrome in high fat diet-induced obese mice through modulation of gut microbiota by sangguayin decoction. 61
31509781 2020
Sodium Orthovanadate Changes Fatty Acid Composition and Increased Expression of Stearoyl-Coenzyme A Desaturase in THP-1 Macrophages. 61
30927246 2020
Ximenynic Acid Regulation of n-3 PUFA Content in Liver and Brain. 61
32036361 2020
High rumen degradable starch decreased goat milk fat via trans-10, cis-12 conjugated linoleic acid-mediated downregulation of lipogenesis genes, particularly, INSIG1. 61
32280461 2020
The NASA Twins Study: The Effect of One Year in Space on Long-Chain Fatty Acid Desaturases and Elongases. 61
32375154 2020
Phenome-wide association studies on cardiovascular health and fatty acids considering phenotype quality control practices for epidemiological data. 61
31797636 2020
Assessment of Fatty Acid Desaturase (Fads2) Structure-Function Properties in Fish in the Context of Environmental Adaptations and as a Target for Genetic Engineering. 61
32023831 2020
Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome. 61
31991592 2020
Effects of Dietary Lipid Composition and Fatty Acid Desaturase 2 Expression in Broodstock Gilthead Sea Bream on Lipid Metabolism-Related Genes and Methylation of the fads2 Gene Promoter in Their Offspring. 61
31835772 2019
A Functional 3' UTR Polymorphism of FADS2 Affects Cow Milk Composition through Modifying Mir-744 Binding. 61
31817629 2019
FADS1 and FADS2 polymorphism are associated with changes in fatty acid concentrations after calorie-restricted Central European and Mediterranean diets. 61
31567872 2019
Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach. 61
31888468 2019
Human milk fatty acid composition is associated with dietary, genetic, sociodemographic, and environmental factors in the CHILD Cohort Study. 61
31589250 2019
Comprehensive transcriptome analysis based on RNA sequencing identifies critical genes for lipopolysaccharide-induced epididymitis in a rat model. 61
31044753 2019
Dietary Fish Oil Alters DNA Methylation of Genes Involved in Polyunsaturated Fatty Acid Biosynthesis in Muscle and Liver of Atlantic Salmon (Salmo salar). 61
31658496 2019
Effects of algae supplementation in high-energy dietary on fatty acid composition and the expression of genes involved in lipid metabolism in Hu sheep managed under intensive finishing system. 61
31276903 2019
Contribution of a genetic risk score to clinical prediction of hepatic steatosis in obese children and adolescents. 61
31255630 2019
Effects of the rs3834458 Single Nucleotide Polymorphism in FADS2 on Levels of n-3 Long-chain Polyunsaturated Fatty Acids: A Meta-analysis. 61
31487670 2019
Maternal polymorphisms in the FADS1 and FADS2 genes modify the association between PUFA ingestion and plasma concentrations of omega-3 polyunsaturated fatty acids. 61
31568926 2019
CRISPR/Cas9-mediated editing of Δ5 and Δ6 desaturases impairs Δ8-desaturation and docosahexaenoic acid synthesis in Atlantic salmon (Salmo salar L.). 61
31729437 2019
Sp1 is Involved in Vertebrate LC-PUFA Biosynthesis by Upregulating the Expression of Liver Desaturase and Elongase Genes. 61
31614732 2019
Influence of iron-deficient diets during gestation and lactation on cerebral fatty acids and eicosanoids in guinea pig offspring-Comparison of studies with different sources of dietary lipids. 61
31422159 2019
Temperature affects liver and muscle metabolism in photostimulated migratory redheaded buntings (Emberiza bruniceps). 61
31410562 2019
The TRPV1 channel regulates glucose metabolism. 61
31408376 2019
Dietary fish oil and flaxseed for rabbit does: fatty acids distribution and Δ6-desaturase enzyme expression of different tissues. 61
30774049 2019
FadR1, a pathway-specific activator of fidaxomicin biosynthesis in Actinoplanes deccanensis Yp-1. 61
31327020 2019
Comparative adipose transcriptome analysis digs out genes related to fat deposition in two pig breeds. 61
31501489 2019
Long-Term Effects of Dietary Olive Oil and Hydrogenated Vegetable Oil on Expression of Lipogenic Genes in Subcutaneous Adipose Tissue of Dairy Cows. 61
31540163 2019
Early nutrition in combination with polymorphisms in fatty acid desaturase gene cluster modulate fatty acid composition of cheek cells' glycerophospholipids in school-age children. 61
31638497 2019
Plasma phospholipid fatty acids, bone mineral density and fracture risk: Evidence from a Mendelian randomization study. 61
31564377 2019
FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health. 61
31433740 2019
Functional diversification of teleost Fads2 fatty acyl desaturases occurs independently of the trophic level. 61
31371768 2019
MicroRNAs Involved in the Regulation of LC-PUFA Biosynthesis in Teleosts: miR-33 Enhances LC-PUFA Biosynthesis in Siganus canaliculatus by Targeting insig1 which in Turn Upregulates srebp1. 61
31020472 2019
FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression. 61
30082751 2019
Novel CB1-ligands maintain homeostasis of the endocannabinoid system in ω3- and ω6-long-chain-PUFA deficiency. 61
31167809 2019
Deficiency or activation of peroxisome proliferator-activated receptor α reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice. 61
31388404 2019
Effects of dietary Antrodia cinnamomea fermented product supplementation on metabolism pathways of antioxidant, inflammatory, and lipid metabolism pathways-a potential crosstalk. 61
31480133 2019
Short-Term Oral UMP/UR Administration Regulates Lipid Metabolism in Early-Weaned Piglets. 61
31461833 2019
Long-chain PUFA profiles in parental diets induce long-term effects on growth, fatty acid profiles, expression of fatty acid desaturase 2 and selected immune system-related genes in the offspring of gilthead seabream. 61
31266551 2019
Fatty acid desaturase 2 is up-regulated by the treatment with statin through geranylgeranyl pyrophosphate-dependent Rho kinase pathway in HepG2 cells. 61
31292513 2019
Delta-6-desaturase (FADS2) inhibition and omega-3 fatty acids in skeletal muscle protein turnover. 61
30923750 2019
Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome. 61
31494266 2019
Serelaxin (recombinant human relaxin-2) treatment affects the endogenous synthesis of long chain poly-unsaturated fatty acids and induces substantial alterations of lipidome and metabolome profiles in rat cardiac tissue. 61
30954631 2019
Fatty Acid Elongase 7 (ELOVL7) Plays a Role in the Synthesis of Long-Chain Unsaturated Fatty Acids in Goat Mammary Epithelial Cells. 61
31242694 2019
Tropical Vegetable Oils Do Not Alter Growth Performance in African Catfish through a High n-6 Polyunsaturated Fatty Acids Biosynthesis Capacity. 61
31006877 2019
Molecular cloning and functional characterization of elongase (elovl5) and fatty acyl desaturase (fads2) in sciaenid, Nibea diacanthus (Lacepède, 1802). 61
30742892 2019
Maternal dietary calcium status during pregnancy and lactation affects brain DHA accretion through modifying DNA methylation of fatty acid desaturases in the mouse offspring. 61
30954344 2019
Reduced delta-6 desaturase activity partially protects against high-fat diet-induced impairment in whole-body glucose tolerance. 61
30928647 2019
A key metabolic gene for recurrent freshwater colonization and radiation in fishes. 61
31147520 2019
Uncovering Plasticity in Tumor Lipid Metabolism. 61
30814093 2019
The combined effects of FADS gene variation and dietary fats in obesity-related traits in a population from the far north of Sweden: the GLACIER Study. 61
29795460 2019
Carrying minor allele of FADS1 and haplotype of FADS1 and FADS2 increased the risk of metabolic syndrome and moderate but not low fat diets lowered the risk in two Korean cohorts. 61
29779171 2019
Correction to: Liver DNA methylation of FADS2 associates with FADS2 genotype. 61
30867039 2019
Fatty acid levels alterations in THP-1 macrophages cultured with lead (Pb). 61
30732887 2019
Double bonds of unsaturated fatty acids differentially regulate mitochondrial cardiolipin remodeling. 61
30764880 2019
Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis. 61
30541029 2019
Pparγ Is Involved in the Transcriptional Regulation of Liver LC-PUFA Biosynthesis by Targeting the Δ6Δ5 Fatty Acyl Desaturase Gene in the Marine Teleost Siganus canaliculatus. 61
30206714 2019
Dietary pattern regulates fatty acid desaturase 1 gene expression in Indian pregnant women to spare overall long chain polyunsaturated fatty acids levels. 61
30511301 2019
Long-chain polyunsaturated fatty acid biosynthesis and its response to cadmium exposure in silver pomfret. 61
30453168 2019
A complete enzymatic capacity for long-chain polyunsaturated fatty acid biosynthesis is present in the Amazonian teleost tambaqui, Colossoma macropomum. 61
30290221 2019
Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatty acids in cardiac remodeling after acute myocardial infarction-Post-hoc analysis from the OMEGA-REMODEL randomized controlled trial. 61
31532795 2019
Dietary EPA and DHA prevent changes in white adipose tissue omega-3 PUFA and oxylipin content associated with a Fads2 deficiency. 61
30368227 2019
The effect of polymorphism in the FADS2 gene on the fatty acid composition of bovine milk. 61
31807666 2019
Liver DNA methylation of FADS2 associates with FADS2 genotype. 61
30654845 2019
A novel polymorphism in the fatty acid desaturase 2 gene (Fads2): A possible role in the basal metabolic rate. 61
30818386 2019
FADS2 and ELOVL6 mutation frequencies in Japanese Crohn's disease patients. 61
31956234 2019
Docosahexaenoic Acid (DHA) Inhibits FADS2 Expression in Astrocytes but Increases Survival of Neurons Co-cultured with DHA-enriched Astrocytes. 61
32489952 2019
Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population. 61
31781193 2019
Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition. 61
31993375 2019
Tissue-Specific Orchestration of Gilthead Sea Bream Resilience to Hypoxia and High Stocking Density. 61
31354511 2019
Gene Expression and Fatty Acid Profiling in Longissimus thoracis Muscle, Subcutaneous Fat, and Liver of Light Lambs in Response to Concentrate or Alfalfa Grazing. 61
31737049 2019
The mechanism through which dietary supplementation with heated linseed grain increases n-3 long-chain polyunsaturated fatty acid concentration in subcutaneous adipose tissue of cashmere kids. 61
30312437 2019
Duration of the flaxseed diet promotes deposition of n-3 fatty acids in the meat and skin of Peking ducks. 61
31839790 2019
Landscape of Loci and Candidate Genes for Muscle Fatty Acid Composition in Pigs Revealed by Multiple Population Association Analysis. 61
31708975 2019
Alpha-Linolenic Acid: It Contribute Regulation of Fertilization Capacity and Subsequent Development by Promoting of Cumulus Expansion during Maturation. 61
30680329 2018
Polyunsaturated fatty acid elongation and desaturation in activated human T-cells: ELOVL5 is the key elongase. 61
30293059 2018
FADS1 and the Timing of Human Adaptation to Agriculture. 61
30272210 2018
Genes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membranes. 61
30453550 2018
Genome-Wide Association Studies of Estimated Fatty Acid Desaturase Activity in Serum and Adipose Tissue in Elderly Individuals: Associations with Insulin Sensitivity. 61
30453627 2018
A novel FADS2 isoform identified in human milk fat globule suppresses FADS2 mediated Δ6-desaturation of omega-3 fatty acids. 61
30041907 2018
Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates. 61
30340454 2018
Two weeks of docosahexaenoic acid (DHA) supplementation increases synthesis-secretion kinetics of n-3 polyunsaturated fatty acids compared to 8 weeks of DHA supplementation. 61
30041049 2018
Transcriptomic analysis of Momordica charantia polysaccharide on streptozotocin-induced diabetic rats. 61
30180967 2018
"Out of the Can": A Draft Genome Assembly, Liver Transcriptome, and Nutrigenomics of the European Sardine, Sardina pilchardus. 61
30304855 2018
Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits. 61
28774683 2018
Triacylglycerol-Lowering Effect of Docosahexaenoic Acid Is Not Influenced by Single-Nucleotide Polymorphisms Involved in Lipid Metabolism in Humans. 61
30407633 2018
Flavonoids as putative modulators of Δ4-, Δ5-, and Δ6-desaturases: Studies in cultured hepatocytes, myocytes, and adipocytes. 61
30365230 2018
A polymorphism in the fatty acid desaturase-2 gene is associated with the arachidonic acid metabolism in pigs. 61
30254373 2018
Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels. 61
30170993 2018
Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy. 61
28161285 2018
FADS1-FADS2 and ELOVL2 gene polymorphisms in susceptibility to autism spectrum disorders in Chinese children. 61
30180836 2018
FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression. 61
30157936 2018
DHA upregulates FADS2 expression in primary cortical astrocytes exposed to vitamin A. 61
29750879 2018
Associations between Fatty Acid Intake and Status, Desaturase Activities, and FADS Gene Polymorphism in Centrally Obese Postmenopausal Polish Women. 61
30103441 2018
Weight gain prevention buffers the impact of CETP rs3764261 on high density lipoprotein cholesterol in young adulthood: The Study of Novel Approaches to Weight Gain Prevention (SNAP). 61
29699816 2018
A rare eicosanoid precursor analogue, sciadonic acid (5Z,11Z,14Z-20:3), detected in vivo in hormone positive breast cancer tissue. 61
29886893 2018
Long-chain polyunsaturated fatty acids, gestation duration, and birth size: a Mendelian randomization study using fatty acid desaturase variants. 61
29878044 2018
Hnf4α is involved in the regulation of vertebrate LC-PUFA biosynthesis: insights into the regulatory role of Hnf4α on expression of liver fatty acyl desaturases in the marine teleost Siganus canaliculatus. 61
29352428 2018
A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study. 61
29746616 2018
Sequence-Based Analysis of Lipid-Related Metabolites in a Multiethnic Study. 61
29610217 2018
Decreased testosterone levels after caponization leads to abdominal fat deposition in chickens. 61
29743036 2018
Fatty acid elongase 5 (ELOVL5) alters the synthesis of long-chain unsaturated fatty acids in goat mammary epithelial cells. 61
29454701 2018
Alteration of Hepatic Gene Expression along with the Inherited Phenotype of Acquired Fatty Liver in Chicken. 61
29642504 2018
CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification. 61
29193869 2018
LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity. 61
29515023 2018
Characteristics of the fads2 gene promoter in marine teleost Epinephelus coioides and role of Sp1-binding site in determining promoter activity. 61
29593294 2018
Transcriptional activation of zebrafish fads2 promoter and its transient transgene expression in yolk syncytial layer of zebrafish embryos. 61
29497119 2018
A common variant in ARHGEF10 alters delta-6 desaturase activity and influence susceptibility to hypertriglyceridemia. 61
29246731 2018
FADS2 inhibition in essential fatty acid deficiency induces hepatic lipid accumulation via impairment of very low-density lipoprotein (VLDL) secretion. 61
29353041 2018
Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population. 61
29491470 2018
Expression analysis of candidate genes for fatty acid composition in adipose tissue and identification of regulatory regions. 61
29391556 2018
The distribution of three candidate cold-resistant SNPs in six minorities in North China. 61
29433421 2018
Temperature and metal exposure affect membrane fatty acid composition and transcription of desaturases and elongases in fathead minnow muscle and brain. 61
29132009 2018
RNA-Seq reveals differentially expressed genes affecting polyunsaturated fatty acids percentage in the Huangshan Black chicken population. 61
29672513 2018
Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes. 61
29636834 2018
PEMT, Δ6 desaturase, and palmitoyldocosahexaenoyl phosphatidylcholine are increased in rats during pregnancy. 61
29167412 2018
Resveratrol Modulates Desaturase Expression and Fatty Acid Composition of Cultured Hepatocytes. 61
30488034 2018
Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells. 61
29556240 2018
The effect of FADS2 gene rs174583 polymorphism on desaturase activities, fatty acid profile, insulin resistance, biochemical indices, and incidence of type 2 diabetes. 61
29937909 2018
The role of fatty acid desaturase (FADS) genes in oleic acid metabolism: FADS1 Δ7 desaturates 11-20:1 to 7,11-20:2. 61
29413358 2018
Ubiquitous Promoters Direct the Expression of Fatty Acid Delta-6 Desaturase from Nile Tilapia (Oreochromis niloticus) in Saccharomyces cerevisiae. 61
31234173 2018
Molecular mechanisms underlying catalytic activity of delta 6 desaturase from Glossomastix chrysoplasta and Thalassiosira pseudonana. 61
29167410 2018
Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression. 61
29590160 2018
Association of Polymorphism in Fatty Acid Desaturase Gene with the Risk of Type 2 Diabetes in Iranian Population. 61
30050886 2018
Cloning and functional characterization of fads2 desaturase and elovl5 elongase from Japanese flounder Paralichthys olivaceus. 61
28943298 2017
The compositional and metabolic responses of gilthead seabream (Sparus aurata) to a gradient of dietary fish oil and associated n-3 long-chain PUFA content. 61
29151385 2017
Genetic mapping using 1.4M SNP array refined loci for fatty acid composition traits in Chinese Erhualian and Bamaxiang pigs. 61
28940847 2017
Individual variation of the extent of milk fat depression in dairy ewes fed fish oil: Milk fatty acid profile and mRNA abundance of candidate genes involved in mammary lipogenesis. 61
29031877 2017
Effects of Dietary n-6:n-3 PUFA Ratios on Lipid Levels and Fatty Acid Profile of Cherry Valley Ducks at 15-42 Days of Age. 61
29084426 2017
Naringenin inhibits alcoholic injury by improving lipid metabolism and reducing apoptosis in zebrafish larvae. 61
29048675 2017
Genetic Polymorphisms in Fatty Acid Metabolism Modify the Association Between Dietary n3: n6 Intake and Risk of Ulcerative Colitis: A Prospective Cohort Study. 61
28991856 2017
Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets. 61
29031400 2017
Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells. 61
28765914 2017
Interactions of bovine oocytes with follicular elements with respect to lipid metabolism. 61
28402007 2017
Molecular and functional characterisation of two elovl4 elongases involved in the biosynthesis of very long-chain (>C24) polyunsaturated fatty acids in black seabream Acanthopagrus schlegelii. 61
28668330 2017
The comprehensive liver transcriptome of two cattle breeds with different intramuscular fat content. 61
28669724 2017
3' UTR G-quadruplexes regulate miRNA binding. 61
28473452 2017
Fads3 modulates docosahexaenoic acid in liver and brain. 61
28838557 2017
Dietary essential α-linolenic acid and linoleic acid differentially modulate TNFα-induced NFκB activity in FADS2-deficient HEK-293 cells. 61
27960561 2017
Identification and characterization of single nucleotide polymorphism markers in FADS2 gene associated with olive oil fatty acids composition. 61
28701171 2017
Association between serum phospholipid fatty acid levels and adiposity in Mexican women. 61
28465289 2017
Impact of temperature on sea bass, Dicentrarchus labrax, retina: Fatty acid composition, expression of rhodopsin and enzymes of lipid and melatonin metabolism. 61
28347705 2017
Two alternative pathways for docosahexaenoic acid (DHA, 22:6n-3) biosynthesis are widespread among teleost fish. 61
28634391 2017
FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes. 61
28555039 2017
In silico pathway analysis and tissue specific cis-eQTL for colorectal cancer GWAS risk variants. 61
28506205 2017
Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation? 61
28334935 2017
Curcumin and linseed oil co-delivered in phospholipid nanoemulsions enhances the levels of docosahexaenoic acid in serum and tissue lipids of rats. 61
28410669 2017
Reduction of Arachidonate Is Associated With Increase in B-Cell Activation Marker in Infants: A Randomized Trial. 61
27276431 2017
Potential protective function of the sterol regulatory element binding factor 1-fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration. 61
28367511 2017
Study protocol to investigate the environmental and genetic aetiology of atopic dermatitis: the Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI). 61
28259851 2017
Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity. 61
28145068 2017
PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c. 61
27932482 2017
Exploration of the perceived and actual benefits of omega-3 fatty acids and the impact of FADS1 and FADS2 genetic information on dietary intake and blood levels of EPA and DHA. 61
28186827 2017
Association of the FADS gene cluster with coronary artery disease and plasma lipid concentrations in the northern Chinese Han population. 61
28237083 2017
The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults. 61
27527582 2017
Brain xanthophyll content and exploratory gene expression analysis: subspecies differences in rhesus macaque. 61
28286579 2017
Long Non-Coding RNA Profiling in a Non-Alcoholic Fatty Liver Disease Rodent Model: New Insight into Pathogenesis. 61
28275212 2017
Prepubertal heifers versus cows-The differences in the follicular environment. 61
27634396 2017
Hesperidin Protects against Acute Alcoholic Injury through Improving Lipid Metabolism and Cell Damage in Zebrafish Larvae. 61
28596796 2017
EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes. 61
28900510 2017
Dietary DHA/EPA ratio affected tissue fatty acid profiles, antioxidant capacity, hematological characteristics and expression of lipid-related genes but not growth in juvenile black seabream (Acanthopagrus schlegelii). 61
28430821 2017
Negative effects of long-term feeding of high-grain diets to lactating goats on milk fat production and composition by regulating gene expression and DNA methylation in the mammary gland. 61
29026537 2017
Physical Interactions and Expression Quantitative Traits Loci Identify Regulatory Connections for Obesity and Type 2 Diabetes Associated SNPs. 61
29081791 2017
Molecular and functional characterization of a fads2 orthologue in the Amazonian teleost, Arapaima gigas. 61
27693628 2017
Regulation of FADS2 transcription by SREBP-1 and PPAR-α influences LC-PUFA biosynthesis in fish. 61
28067297 2017
Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster. 61
28957329 2017
Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up. 61
28598979 2017
Effect of feeding lambs with a tanniferous shrub (rockrose) and a vegetable oil blend on fatty acid composition of meat lipids. 61
27306827 2016
Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio. 61
27613800 2016
A fatty acyl desaturase (fads2) with dual Δ6 and Δ5 activities from the freshwater carnivorous striped snakehead Channa striata. 61
27421235 2016
Analysis of the Uterine Epithelial and Conceptus Transcriptome and Luminal Fluid Proteome During the Peri-Implantation Period of Pregnancy in Sheep. 61
27535962 2016
Systematic analysis of the regulatory functions of microRNAs in chicken hepatic lipid metabolism. 61
27535581 2016
Alternative splicing generates novel Fads3 transcript in mice. 61
27216536 2016
Correction: Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: protocol for a collaborative meta-analysis. 61
27489150 2016
Echium oil increased the expression of a Δ4 Fads2 fatty acyl desaturase and the deposition of n-3 long-chain polyunsaturated fatty acid in comparison with linseed oil in striped snakehead (Channa striata) muscle. 61
26842427 2016
Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits. 61
27399967 2016
Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic Acid. 61
27188529 2016
FADS2 genotype influences whole-body resting fat oxidation in young adult men. 61
27144909 2016
Fads1 and 2 are promoted to meet instant need for long-chain polyunsaturated fatty acids in goose fatty liver. 61
27344166 2016
Influence of difenoconazole on lipid metabolism in marine medaka (Oryzias melastigma). 61
27112457 2016
Characterization of long non-coding RNA transcriptome in high-energy diet induced nonalcoholic steatohepatitis minipigs. 61
27466003 2016
Regulation of glucose and lipid metabolism by dietary carbohydrate levels and lipid sources in gilthead sea bream juveniles. 61
27160810 2016
The delta 6 desaturase knock out mouse reveals that immunomodulatory effects of essential n-6 and n-3 polyunsaturated fatty acids are both independent of and dependent upon conversion. 61
27142734 2016
Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders. 61
27341449 2016
Dietary Oil Source and Selenium Supplementation Modulate Fads2 and Elovl5 Transcriptional Levels in Liver and Brain of Meagre (Argyrosomus regius). 61
27169705 2016
Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: protocol for a collaborative meta-analysis. 61
27311901 2016
Association of polyunsaturated fatty acids in breast milk with fatty acid desaturase gene polymorphisms among Chinese lactating mothers. 61
27269715 2016
Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity. 61
27085774 2016
A High-Fat, High-Oleic Diet, But Not a High-Fat, Saturated Diet, Reduces Hepatic α-Linolenic Acid and Eicosapentaenoic Acid Content in Mice. 61
26694605 2016
Genome-wide association studies for fatty acid metabolic traits in five divergent pig populations. 61
27097669 2016
Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding. 61
26750116 2016
Fatty acid composition of chicken breast meat is dependent on genotype-related variation of FADS1 and FADS2 gene expression and desaturating activity. 61
26670346 2016
Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis. 61
26805387 2016
Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior. 61
26513616 2016
Desaturase and elongase-limiting endogenous long-chain polyunsaturated fatty acid biosynthesis. 61
26828581 2016
Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease. 61
27004414 2016
Synthesis of docosahexaenoic acid from eicosapentaenoic acid in retina neurons protects photoreceptors from oxidative stress. 61
26662863 2016
Expression profiling analysis: Uncoupling protein 2 deficiency improves hepatic glucose, lipid profiles and insulin sensitivity in high-fat diet-fed mice by modulating expression of genes in peroxisome proliferator-activated receptor signaling pathway. 61
27042269 2016
A Transgenic Camelina sativa Seed Oil Effectively Replaces Fish Oil as a Dietary Source of Eicosapentaenoic Acid in Mice. 61
26791554 2016
FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome. 61
26879377 2016
Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 ɑ-linolenic acids for FADS2 mediated Δ6-desaturation. 61
26597785 2016
Activity, Expression, and Substrate Preference of the Δ(6)-Desaturase in Slow- or Fast-Growing Rabbit Genotypes. 61
26745387 2016
Correlating chemical sensitivity and basal gene expression reveals mechanism of action. 61
26656090 2016
Genetic Variants of the FADS Gene Cluster Are Associated with Erythrocyte Membrane LC PUFA Levels in Patients with Mild Cognitive Impairment. 61
27273350 2016
[Sperm acrosome formation-associated genes in mice: Advances in studies]. 61
26931031 2016
Isolation and Functional Characterisation of a fads2 in Rainbow Trout (Oncorhynchus mykiss) with Δ5 Desaturase Activity. 61
26943160 2016
FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue. 61
26609056 2016
Cloning and functional characterization of Δ6 fatty acid desaturase (FADS2) in Eurasian perch (Perca fluviatilis). 61
26478265 2016
Purified Betacyanins from Hylocereus undatus Peel Ameliorate Obesity and Insulin Resistance in High-Fat-Diet-Fed Mice. 61
26653843 2016
[Desaturases of fatty acids (FADS) and their physiological and clinical implication]. 61
27088787 2016
Genomic and Metabolomic Profile Associated to Clustering of Cardio-Metabolic Risk Factors. 61
27589269 2016
Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque. 61
27382320 2016
A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits. 61
27322064 2016
Effects of Addition of Linseed and Marine Algae to the Diet on Adipose Tissue Development, Fatty Acid Profile, Lipogenic Gene Expression, and Meat Quality in Lambs. 61
27253325 2016
Transgenesis of humanized fat1 promotes n-3 polyunsaturated fatty acid synthesis and expression of genes involved in lipid metabolism in goat cells. 61
26474750 2016
The mining chemical Polydadmac is cytotoxic but does not interfere with Cu-induced toxicity in Atlantic salmon hepatocytes. 61
26368670 2015
Dietary Linseed Oil Reduces Growth While Differentially Impacting LC-PUFA Synthesis and Accretion into Tissues in Eurasian Perch (Perca fluviatilis). 61
26439838 2015
Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study. 61
26474818 2015
Forms of n-3 (ALA, C18:3n-3 or DHA, C22:6n-3) Fatty Acids Affect Carcass Yield, Blood Lipids, Muscle n-3 Fatty Acids and Liver Gene Expression in Lambs. 61
26395388 2015
Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance. 61
26455892 2015
Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part I: maternal FADS2 genotype and DNA methylation correlate with polyunsaturated fatty acid status in toddlers: an exploratory analysis. 61
26439440 2015
A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population. 61
26584805 2015
Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes. 61
26251408 2015
Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. 61
26365444 2015
Polyunsaturated fatty acid metabolism in a marine teleost, Nibe croaker Nibea mitsukurii: Functional characterization of Fads2 desaturase and Elovl5 and Elovl4 elongases. 61
26112824 2015
The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells. 61
26065859 2015
Excess Linoleic Acid Increases Collagen I/III Ratio and "Stiffens" the Heart Muscle Following High Fat Diets. 61
26240151 2015
Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice. 61
26033744 2015
Lipidomic analysis reveals a radiosensitizing role of gamma-linolenic acid in glioma cells. 61
26092623 2015
Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor. 61
25864624 2015
Polymorphisms of rs174616 in the FADS1-FADS2 gene cluster is associated with a reduced risk of type 2 diabetes mellitus in northern Han Chinese people. 61
25981324 2015
Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver. 61
25921305 2015
Effect of vitamin E supplementation or alfalfa grazing on fatty acid composition and expression of genes related to lipid metabolism in lambs. 61
26115290 2015
Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n-3 and n-6 polyunsaturated fatty acids. 61
25581263 2015
Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. 61
25550171 2015
Three unsaturated fatty acid biosynthesis-related genes in yellow catfish Pelteobagrus fulvidraco: Molecular characterization, tissue expression and transcriptional regulation by leptin. 61
25497832 2015
Influence of the cis-9, cis-12 and cis-15 double bond position in octadecenoic acid (18:1) isomers on the rat FADS2-catalyzed Δ6-desaturation. 61
25701799 2015
Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function. 61
25755223 2015
Genomic structural analysis of porcine fatty acid desaturase cluster on chromosome 2. 61
25409917 2015
The capacity for long-chain polyunsaturated fatty acid synthesis in a carnivorous vertebrate: Functional characterisation and nutritional regulation of a Fads2 fatty acyl desaturase with Δ4 activity and an Elovl5 elongase in striped snakehead (Channa striata). 61
25542509 2015
Anthocyanins do not influence long-chain n-3 fatty acid status: studies in cells, rodents and humans. 61
25573539 2015
Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. 61
25646338 2015
Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol. 61
25765115 2015
Activation of ATP citrate lyase by mTOR signal induces disturbed lipid metabolism in hepatitis B virus pre-S2 mutant tumorigenesis. 61
25339766 2015
Gene Expression Signature in Adipose Tissue of Acromegaly Patients. 61
26087292 2015
Fatty acid desaturase 1 gene polymorphisms control human hepatic lipid composition. 61
25123259 2015
Genetic variants of FADS gene cluster, plasma LC-PUFA levels and the association with cognitive function of under-two-year-old Sasaknese Indonesian children. 61
26078250 2015
Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study. 61
25914723 2015
Genetic Contribution of Variants near SORT1 and APOE on LDL Cholesterol Independent of Obesity in Children. 61
26375028 2015
DNA methylation perturbations in genes involved in polyunsaturated Fatty Acid biosynthesis associated with depression and suicide risk. 61
25972837 2015
Association of two polymorphisms in the FADS1/FADS2 gene cluster and the risk of coronary artery disease and ischemic stroke. 61
26261632 2015
A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes. 61
24934276 2014
Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation. 61
25367143 2014
Fatty acid and phospholipid biosynthetic pathways are regulated throughout mammary epithelial cell differentiation and correlate to breast cancer survival. 61
24970396 2014
Role of maternal tissue in the synthesis of polyunsaturated fatty acids in response to a lipid-deficient diet during pregnancy and lactation in rats. 61
25046614 2014
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. 61
25352340 2014
Genetic determinants of P wave duration and PR segment. 61
24850809 2014
Effects of pasture versus confinement and marine oil supplementation on the expression of genes involved in lipid metabolism in mammary, liver, and adipose tissues of lactating dairy cows. 61
24792801 2014
Diversification of substrate specificities in teleostei Fads2: characterization of Δ4 and Δ6Δ5 desaturases of Chirostoma estor. 61
24792929 2014
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. 61
24836286 2014
N-3 fatty acid intake altered fat content and fatty acid distribution in chicken breast muscle, but did not influence mRNA expression of lipid-related enzymes. 61
24894510 2014
The role of FADS1/2 polymorphisms on cardiometabolic markers and fatty acid profiles in young adults consuming fish oil supplements. 61
24936800 2014
Adjacent SNPs in the transcriptional regulatory region of the FADS2 gene associated with fatty acid and growth traits in chickens. 61
24841665 2014
Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease. 61
24406470 2014
Interactive effects of in utero nutrition and genetic inheritance on cognition: new evidence using sibling comparisons. 61
24172871 2014
Fatty acids and epigenetics. 61
24322369 2014
Is hepatic lipid metabolism of beef cattle influenced by breed and dietary silage level? 61
24621212 2014
Unsaturated fatty acids, desaturases, and human health. 61
24460221 2014
Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. 61
24057673 2014
Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice. 61
24320056 2014
Associations between variants of FADS genes and omega-3 and omega-6 milk fatty acids of Canadian Holstein cows. 61
24533445 2014
Effect of sex hormones on n-3 polyunsaturated fatty acid biosynthesis in HepG2 cells and in human primary hepatocytes. 61
24411721 2014
Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young. 61
24240437 2014
Increased FADS2-derived n-6 PUFAs and reduced n-3 PUFAs in plasma of atopic dermatitis patients. 61
24854601 2014
Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). 61
24346170 2014
Regulation of tissue LC-PUFA contents, Δ6 fatty acyl desaturase (FADS2) gene expression and the methylation of the putative FADS2 gene promoter by different dietary fatty acid profiles in Japanese seabass (Lateolabrax japonicus). 61
24498178 2014
Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. 61
24378641 2014
Loss of FADS2 function severely impairs the use of HeLa cells as an in vitro model for host response studies involving fatty acid effects. 61
25549244 2014
DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. 61
24842322 2014
Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease. 61
25038994 2014
Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells. 61
25329159 2014
Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency. 61
24184513 2014
Dietary strategy to repair plasma membrane after brain trauma: implications for plasticity and cognition. 61
23911971 2014
Conservation of lipid metabolic gene transcriptional regulatory networks in fish and mammals. 61
24177230 2014
Alterations in hepatic miRNA expression during negative energy balance in postpartum dairy cattle. 61
24428929 2014
Effect of varying dietary levels of LC-PUFA and vegetable oil sources on performance and fatty acids of Senegalese sole post larvae: puzzling results suggest complete biosynthesis pathway from C18 PUFA to DHA. 61
24120522 2014
Maternal fatty acids in pregnancy, FADS polymorphisms, and child intelligence quotient at 8 y of age. 61
24067669 2013
Trans-vaccenate is Δ13-desaturated by FADS3 in rodents. 61
24070791 2013
Fatty acid desaturase 2 (FADS2) insertion/deletion polymorphism impact on muscle fatty acid profile in European grayling (Thymallus thymallus). 61
23578405 2013
Interaction of fatty acid genotype and diet on changes in colonic fatty acids in a Mediterranean diet intervention study. 61
24022589 2013
Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. 61
24075244 2013
Characterization of fatty acid delta-6 desaturase gene in Nile tilapia and heterogenous expression in Saccharomyces cerevisiae. 61
23939229 2013
Differential gene expression in cumulus oocyte complexes collected by ovum pick up from repeat breeder and normally fertile Holstein Friesian heifers. 61
23911014 2013
Variation in the FADS1/2 gene cluster alters plasma n-6 PUFA and is weakly associated with hsCRP levels in healthy young adults. 61
23867726 2013
Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. 61
23813869 2013
Polymorphisms in Fatty Acid Desaturase (FADS) Gene Cluster: Effects on Glycemic Controls Following an Omega-3 Polyunsaturated Fatty Acids (PUFA) Supplementation. 61
24705214 2013
Dietary and ontogenic regulation of fatty acid desaturase and elongase expression in broiler chickens. 61
23809327 2013
Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma. 61
23749645 2013
A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems. 61
23737301 2013
Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver. 61
23107313 2013
Delta-6-desaturase gene polymorphism is associated with lipoprotein oxidation in vitro. 61
23721366 2013
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. 61
23362303 2013
How selected tissues of lactating holstein cows respond to dietary polyunsaturated fatty acid supplementation. 61
23129256 2013
Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study. 61
23404124 2013
Hormone-sensitive lipase deficiency disturbs the fatty acid composition of mouse testis. 61
23369366 2013
Candidate gene marker associations with fatty acid profiles in heavy pigs. 61
23273456 2013
Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement. 61
23160180 2013
Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children. 61
24167612 2013
Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers. 61
22997227 2013
Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. 61
22398025 2013
Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses. 61
23844124 2013
Fatty Acid desaturase gene polymorphisms and metabolic measures in schizophrenia and bipolar patients taking antipsychotics. 61
24455201 2013
Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. 61
23221573 2013
FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain. 61
23826354 2013
A case-control study between gene polymorphisms of polyunsaturated fatty acid metabolic rate-limiting enzymes and acute coronary syndrome in Chinese Han population. 61
23555103 2013
Genetic variation in FADS genes and plasma cholesterol levels in 2-year-old infants: KOALA Birth Cohort Study. 61
23667444 2013
TGFβ signaling regulates lipogenesis in human sebaceous glands cells. 61
23343495 2013
Dietary alpha-linolenic acid does not enhance accumulation of omega-3 long-chain polyunsaturated fatty acids in barramundi (Lates calcarifer). 61
23085323 2013
Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men. 61
23818766 2013
Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. 61
24040040 2013
Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males. 61
22960237 2012
Association of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjects. 61
22884424 2012
L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease. 61
22796714 2012
Regulation of inflammatory and lipid metabolism genes by eicosapentaenoic acid-rich oil. 61
22556214 2012
Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. 61
22743310 2012
Nutritional aspects of epigenetic inheritance. 61
22803604 2012
A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids. 61
22619218 2012
Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin. 61
22748975 2012
Influence of pregnancy on the adipocytokine and peroxisome proliferator-activated receptor pathways in peripheral blood mononuclear cells from healthy donors and rheumatoid arthritis patients. 61
22231457 2012
Interactions between dietary n-3 fatty acids and genetic variants and risk of disease. 61
22591901 2012
Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids. 61
22503634 2012
Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms. 61
22194195 2012
Changes in rat n-3 and n-6 fatty acid composition during pregnancy are associated with progesterone concentrations and hepatic FADS2 expression. 61
22495065 2012
Characteristics of fads2 gene expression and putative promoter in European sea bass (Dicentrarchus labrax): comparison with salmonid species and analysis of CpG methylation. 61
22325717 2012
Coexisting role of fasting or feeding and dietary lipids in the control of gene expression of enzymes involved in the synthesis of saturated, monounsaturated and polyunsaturated fatty acids. 61
22248624 2012
Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a US urban black population. 61
21847588 2012
Recent insights into the relation of Δ5 desaturase and Δ6 desaturase activity to the development of type 2 diabetes. 61
22123669 2012
FADS gene cluster modulates the effect of breastfeeding on asthma. Results from the GINIplus and LISAplus studies. 61
21933193 2012
Age and haplotype variations within FADS1 interact and associate with alterations in fatty acid composition in human male cortical brain tissue. 61
22900039 2012
Induction of 1-acylglycerophosphocholine acyltransferase genes by fibrates in the liver of rats. 61
22975502 2012
Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis. 61
22509311 2012
Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan Eskimos. 61
22701466 2012
Fats and factors: lipid profiles associate with personality factors and suicidal history in bipolar subjects. 61
22253709 2012
Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. 61
22384110 2012
FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies. 61
22629455 2012
A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population. 61
21917437 2011
The polypyrimidine tract binding protein regulates desaturase alternative splicing and PUFA composition. 61
21980057 2011
FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children. 61
21793953 2011
Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). 61
22013196 2011
Fatty acid desaturase 2 promoter mutation is not responsible for Δ6-desaturase deficiency. 61
21629299 2011
Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice. 61
21653892 2011
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. 61
22001757 2011
Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses. 61
21977987 2011
Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status. 61
22024496 2011
Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis. 61
21457203 2011
Delta-8 desaturation activity varies among fatty acyl desaturases of teleost fish: high activity in delta-6 desaturases of marine species. 61
21571087 2011
FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents. 61
21593353 2011
Insulin induces fatty acid desaturase expression in human monocytes. 61
21413848 2011
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. 61
21829377 2011
Implications of discoveries from genome-wide association studies in current cardiovascular practice. 61
21860704 2011
Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults. 61
21414826 2011
Postpartum changes in maternal and infant erythrocyte fatty acids are likely to be driven by restoring insulin sensitivity and DHA status. 61
21388747 2011
Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression. 61
21458237 2011
The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol. 61
21444760 2011
Growth hormone enhances arachidonic acid metabolites in a growth hormone transgenic mouse. 61
21442273 2011
Participation of mammary gland in long-chain polyunsaturated fatty acid synthesis during pregnancy and lactation in rats. 61
21292028 2011
Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study. 61
21513558 2011
Dietary arachidonate differentially alters desaturase-elongase pathway flux and gene expression in liver and intestine of suckling pigs. 61
21310868 2011
[A case-control study between gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and paranoid schizophrenia of Han ethnicity in Jilin Province]. 61
21560298 2011
Phospholipidosis induced by PPARγ signaling in human bronchial epithelial (BEAS-2B) cells exposed to amiodarone. 61
21123845 2011
Reduced expression of fatty acid biosynthesis genes in the prefrontal cortex of patients with major depressive disorder. 61
20863572 2011
Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. 61
21184748 2011
Microarray analysis of cultured rat hippocampal neurons treated with brain derived neurotrophic factor. 61
20535563 2011
Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. 61
21383846 2011
Elevated Delta-6 desaturase (FADS2) gene expression in the prefrontal cortex of patients with bipolar disorder. 61
20615514 2011
FADS gene polymorphisms in Koreans: association with ω6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease. 61
21040914 2011
Cognitive function in adolescence: testing for interactions between breast-feeding and FADS2 polymorphisms. 61
21156270 2011
FADS2 function loss at the cancer hotspot 11q13 locus diverts lipid signaling precursor synthesis to unusual eicosanoid fatty acids. 61
22140540 2011
Elongase reactions as control points in long-chain polyunsaturated fatty acid synthesis. 61
22216341 2011
Fatty Acid Desaturase 3 (Fads3) is a singular member of the Fads cluster. 61
20226833 2011
Effects of perfluorinated fatty acids with different carbon chain length on fatty acid profiles of hepatic lipids in mice. 61
21628884 2011
Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. 61
21106917 2011
Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. 61
20980488 2011
Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study. 61
20691134 2010
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life. 61
20948998 2010
Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state. 61
20610391 2010
FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population. 61
20562440 2010
Effect of PUFA on embryo cryoresistance, gene expression and AMPKalpha phosphorylation in IVF-derived bovine embryos. 61
20601073 2010
Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression. 61
20573490 2010
Regulation of FADS2 expression and activity in European sea bass (Dicentrarchus labrax, L.) fed a vegetable diet. 61
20363355 2010
Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. 61
20427696 2010
FADS2 polymorphisms modify the effect of breastfeeding on child IQ. 61
20644632 2010
Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism. 61
20045144 2010
Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk. 61
20558833 2010
Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study. 61
20484448 2010
Genetic variation in lipid desaturases and its impact on the development of human disease. 61
20565855 2010
Do FADS genotypes enhance our knowledge about fatty acid related phenotypes? 61
19948371 2010
Alternative splicing generates a novel FADS2 alternative transcript in baboons. 61
19693691 2010
A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle. 61
20364269 2010
FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk. 61
20335541 2010
Alternative transcripts of fatty acid desaturase (FADS) genes. 61
20236814 2010
The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. 61
20018209 2010
The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues. 61
19752397 2010
Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism. 61
19809313 2010
A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1. 61
19546342 2010
Genomic dissection of population substructure of Han Chinese and its implication in association studies. 61
19944404 2009
Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing. 61
19573581 2009
Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration. 61
19351970 2009
An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3. 61
19202133 2009
Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition. 61
19195843 2009
Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome? 61
19144731 2009
Association of fatty acid desaturase gene polymorphisms with blood lipid essential fatty acids and perinatal depression among Canadian women: a pilot study. 61
20395685 2009
Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. 61
18479586 2009
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. 61
19060910 2009
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. 61
19060911 2009
Common variants at 30 loci contribute to polygenic dyslipidemia. 61
19060906 2009
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. 61
19148276 2009
FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases. 61
19776639 2009
Transcriptome profiling of the feeding-to-fasting transition in chicken liver. 61
19091074 2008
Liver TAG transiently decreases while PL n-3 and n-6 fatty acids are persistently elevated in insulin resistant mice. 61
18763007 2008
Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. 61
18936223 2008
FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. 61
18842780 2008
Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids. 61
19172737 2008
Long-term phytosterol treatment alters gene expression in the liver of apo E-deficient mice. 61
18155511 2008
SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease. 61
18320251 2008
Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance. 61
18030445 2008
Genetically determined variation in polyunsaturated fatty acid metabolism may result in different dietary requirements. 61
18626191 2008
Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia. 61
17971455 2007
Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. 61
17984066 2007
Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response. 61
17823443 2007
alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. 61
17284757 2007
Association of the FADS2 gene with omega-6 and omega-3 PUFA Concentration in the egg yolk of Japanese quail. 61
17612842 2007
Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder. 61
16893529 2006
Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. 61
16670158 2006
Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism. 61
16105858 2006
The surprising diversity of Delta6-desaturase substrates. 61
14748719 2004
A nucleotide insertion in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency. 61
12951357 2003
Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity. 61
12713571 2003
Conversion of hexadecanoic acid to hexadecenoic acid by rat Delta 6-desaturase. 61
12562851 2003
cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. 61
10860662 2000

Variations for Fetal Akinesia Deformation Sequence 2

ClinVar genetic disease variations for Fetal Akinesia Deformation Sequence 2:

6 (showing 3, show less) ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 RAPSN RAPSN, 2-BP DEL, 1177AAdeletion Pathogenic 8057
2 RAPSN NM_005055.5(RAPSN):c.416T>C (p.Phe139Ser)SNV Pathogenic 8058 rs121909256 11:47469479-47469479 11:47447927-47447927
3 RAPSN NM_005055.5(RAPSN):c.566C>T (p.Ala189Val)SNV Pathogenic 8059 rs121909257 11:47464332-47464332 11:47442780-47442780

UniProtKB/Swiss-Prot genetic disease variations for Fetal Akinesia Deformation Sequence 2:

73 (showing 2, show less)
# Symbol AA change Variation ID SNP ID
1 RAPSN p.Phe139Ser VAR_043899 rs121909256
2 RAPSN p.Ala189Val VAR_043902 rs121909257

Expression for Fetal Akinesia Deformation Sequence 2

Search GEO for disease gene expression data for Fetal Akinesia Deformation Sequence 2.

Pathways for Fetal Akinesia Deformation Sequence 2

GO Terms for Fetal Akinesia Deformation Sequence 2

Sources for Fetal Akinesia Deformation Sequence 2

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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