FASD
MCID: FTL006
MIFTS: 49

Fetal Alcohol Spectrum Disorder (FASD)

Categories: Fetal diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Fetal Alcohol Spectrum Disorder

MalaCards integrated aliases for Fetal Alcohol Spectrum Disorder:

Name: Fetal Alcohol Spectrum Disorder 12 15
Fetal Alcohol Spectrum Disorders 53 43 3 73
Alcohol-Related Neurodevelopmental Disorder - Type 53
Alcohol-Related Birth Defects - Type 53
Fetal Alcohol Syndrome - Type 53
Fetal Alcohol Syndrome 73
Fasd 53

Classifications:



External Ids:

Disease Ontology 12 DOID:0050696

Summaries for Fetal Alcohol Spectrum Disorder

MedlinePlus : 43 Alcohol can harm your baby at any stage during a pregnancy. That includes the earliest stages, before you even know you are pregnant. Drinking during pregnancy can cause a group of conditions called fetal alcohol spectrum disorders (FASDs). Children who are born with FASD can have a mix of problems, such as medical, behavioral, educational, and social problems. The kinds of problems they have depend on which type of FASD they have. The problems could include Abnormal facial features, such as a smooth ridge between the nose and upper lip Small head size Shorter-than-average height Low body weight Poor coordination Hyperactive behavior Difficulty with attention and memory Learning disabilities and difficulty in school Speech and language delays Intellectual disability or low IQ Poor reasoning and judgment skills Sleep and sucking problems as a baby Vision or hearing problems Problems with the heart, kidneys, or bones Fetal alcohol syndrome (FAS) is the most serious type of FASD. People with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. Diagnosing FASD can be hard because there is no medical test for it. The health care provider will make a diagnosis by looking at the child's signs and symptoms, and will ask whether the mother drank alcohol during pregnancy. FASDs last a lifetime. There is no cure for FASDs, but treatments can help. These include medicines to help with some symptoms, medical care for health problems, behavior and education therapy, and parent training. A good treatment plan is specific to the child's problems. It should include close monitoring, follow-ups, and changes when needed. Certain "protective factors" can help reduce the effects of FASDs and help people who have them reach their full potential. They include Diagnosis before 6 years of age Loving, nurturing, and stable home environment during the school years Absence of violence around them Involvement in special education and social services There is no known safe amount of alcohol during pregnancy. To prevent FASDs, you should not drink alcohol while you are pregnant, or when you might get pregnant. Centers for Disease Control and Prevention

MalaCards based summary : Fetal Alcohol Spectrum Disorder, also known as fetal alcohol spectrum disorders, is related to fetal alcohol syndrome and alcohol-related neurodevelopmental disorder. An important gene associated with Fetal Alcohol Spectrum Disorder is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are Ras signaling pathway and Glucose metabolism. The drugs Ethanol and Epigallocatechin have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and kidney, and related phenotypes are Decreased shRNA abundance and Decreased shRNA abundance

Disease Ontology : 12 A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.

Wikipedia : 76 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose... more...

Related Diseases for Fetal Alcohol Spectrum Disorder

Graphical network of the top 20 diseases related to Fetal Alcohol Spectrum Disorder:



Diseases related to Fetal Alcohol Spectrum Disorder

Symptoms & Phenotypes for Fetal Alcohol Spectrum Disorder

GenomeRNAi Phenotypes related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00251-A-1 9.17 ALDH9A1
2 Decreased shRNA abundance GR00251-A-2 9.17 ALDH9A1
3 Decreased shRNA abundance GR00297-A 9.17 ADH6 AKR1A1 ALDH9A1 DIO3 SV2C

MGI Mouse Phenotypes related to Fetal Alcohol Spectrum Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.96 ADH7 AKR1A1 ASPH BDNF DIO3 GRIN2B
2 mortality/aging MP:0010768 9.9 ADH7 ADNP AKR1A1 ASPH BDNF CUX2
3 craniofacial MP:0005382 9.8 AKR1A1 ASPH BDNF IGF2 PFAS SHH
4 nervous system MP:0003631 9.61 ADH7 ADNP BDNF CUX2 GRIN2A GRIN2B
5 taste/olfaction MP:0005394 8.8 ADH7 BDNF SHH

Drugs & Therapeutics for Fetal Alcohol Spectrum Disorder

Drugs for Fetal Alcohol Spectrum Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
2
Epigallocatechin Experimental, Investigational Phase 2, Phase 3 970-74-1 72277
3
Epigallocatechin gallate Investigational Phase 2, Phase 3 989-51-5 65064
4 Antioxidants Phase 2, Phase 3
5 Protective Agents Phase 2, Phase 3
6 Neuroprotective Agents Phase 2, Phase 3
7 Anti-Infective Agents, Local Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
8 Central Nervous System Depressants Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
9 Anti-Infective Agents Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
10 Neurotransmitter Agents Phase 3,Phase 1
11 Atomoxetine Hydrochloride Phase 3,Phase 1
12 Neurotransmitter Uptake Inhibitors Phase 3,Phase 1
13 Adrenergic Agents Phase 3,Phase 1
14
Choline Approved, Nutraceutical Phase 2,Phase 1 62-49-7 305
15 Nootropic Agents Phase 2,Phase 1
16 Lipid Regulating Agents Phase 2,Phase 1
17 Antimetabolites Phase 2,Phase 1
18 Gastrointestinal Agents Phase 2,Phase 1
19 Hypolipidemic Agents Phase 2,Phase 1
20
Nicotine Approved Not Applicable 54-11-5 942 89594
21 tannic acid Approved Not Applicable
22
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Epigallocatechin Gallate (EGCG) to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children Unknown status NCT02558933 Phase 2, Phase 3
2 Open-Label Study of the Long Term Tolerability and Safety of Atomoxetine in Children With FASD and ADD/ADHD Completed NCT00418262 Phase 3 Atomoxetine
3 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
4 Fetal Alcohol Syndrome/ARND Research Consortion Completed NCT00164554 Phase 1, Phase 2
5 Fetal Alcohol Syndrome: Socio-Cognitive Habilitation Completed NCT00164229 Phase 1, Phase 2
6 Neurocognitive Habilitation for Children With Fetal Alcohol Syndrome (FAS)/Alcohol-Related Neurodevelopmental Disorder (ARND) Completed NCT00164346 Phase 1, Phase 2
7 A Media Based Motivational Intervention to Prevent Alcohol Exposed Pregnancies (AEPs) Completed NCT00219336 Phase 2
8 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2 Choline bitartrate
9 Project CHOICES Efficacy Study Completed NCT00153478 Phase 2
10 Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Recruiting NCT02735473 Phase 2 Choline bitartrate;Placebo
11 Neighborhood Alcohol & HIV Prevention in South African Townships (Philani) Active, not recruiting NCT00996528 Phase 2
12 Assess the Effectiveness of Atomoxetine in Children With Fetal Alcohol Syndrome and ADD/ADHD Completed NCT00417794 Phase 1 Strattera;Placebo
13 Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With FASD Completed NCT01536184 Not Applicable
14 Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention Completed NCT02457676 Not Applicable
15 Parenting Training for Children With FASD Completed NCT02210455 Not Applicable
16 Contraception and Alcohol Risk Reduction Internet Intervention Randomized Trial Completed NCT02128880 Not Applicable
17 Development of Education Materials for Prevention of FAS in Russia Completed NCT01971398 Not Applicable
18 Preventing FAS/ARND in Russian Children Completed NCT01961050 Not Applicable
19 Nutritional Risk Factors for FASD in Ukraine Completed NCT03782935 Not Applicable
20 Self-Regulation in Adolescents With FASD: The Efficacy of a Targeted Intervention Completed NCT02912962 Not Applicable
21 Fetal Alcohol Damage Prevention Study Completed NCT00696085 Not Applicable
22 Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603 Not Applicable
23 Healthy Moms Alcohol Intervention Completed NCT00244062 Not Applicable
24 Comprehensive Program for Youth Mental Health Completed NCT02169960 Not Applicable
25 Modeling and Testing Change in Mental Abilities in Childhood Completed NCT02459873 Not Applicable
26 Effects of Hyperbaric Oxygen Therapy in Autistic Children: A Pilot Study Completed NCT00324909 Not Applicable Hyperbaric Oxygen Therapy
27 Reducing Alcohol Exposed Pregnancy Risk: EARLY Randomized Controlled Trial Completed NCT01446653 Not Applicable
28 Fetal Alcohol Spectrum Disorder-Is This a Ciliopathy? Recruiting NCT03802708 Not Applicable
29 A Study of Parent and Child Emotions in Fetal Alcohol Spectrum Disorder (FASD) Recruiting NCT03524664 Not Applicable
30 Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum Disorder Recruiting NCT03494738
31 Cognitive Training and tDCS for Children With FASD Recruiting NCT03361293 Not Applicable
32 In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions Recruiting NCT03371641 Not Applicable
33 Prenatal Alcohol Biomarker Study in Uruguay Recruiting NCT02600624
34 Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial Recruiting NCT03342495 Not Applicable
35 Effects of Prenatal Alcohol Exposure on Emotional and Cognitive Abilities in Adults Active, not recruiting NCT03793920 Not Applicable
36 Prevention of Fetal Alcohol Spectrum Disorder (FASD) by the Use of Technology Enrolling by invitation NCT02759874 Not Applicable
37 Better Nights, Better Days for Children With Neurodevelopment Disorders Not yet recruiting NCT02694003 Not Applicable
38 Evaluating the Efficacy of a Video Based Intervention to Educate Teen Moms About Fetal Alcohol Syndrome (FAS) Terminated NCT00747630 Early Phase 1

Search NIH Clinical Center for Fetal Alcohol Spectrum Disorder

Genetic Tests for Fetal Alcohol Spectrum Disorder

Anatomical Context for Fetal Alcohol Spectrum Disorder

MalaCards organs/tissues related to Fetal Alcohol Spectrum Disorder:

41
Testes, Eye, Kidney, Heart, Bone, Brain, Cortex

Publications for Fetal Alcohol Spectrum Disorder

Articles related to Fetal Alcohol Spectrum Disorder:

(show top 50) (show all 695)
# Title Authors Year
1
Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder. ( 29953483 )
2018
2
Global Prevalence of Fetal Alcohol Spectrum Disorder in Italy-Reply. ( 29582069 )
2018
3
Fetal alcohol spectrum disorder and youth justice: a prevalence study among young people sentenced to detention in Western Australia. ( 29440216 )
2018
4
An evaluation of the predictive validity of the SAVRY and YLS/CMI in justice-involved youth with fetal alcohol spectrum disorder. ( 29952591 )
2018
5
DNA methylation as a predictor of fetal alcohol spectrum disorder. ( 29344313 )
2018
6
Utility of Genetic Testing in Fetal Alcohol Spectrum Disorder. ( 29398060 )
2018
7
Assessing motor skills to inform a Fetal Alcohol Spectrum Disorder diagnosis focusing on persons older than 12 years: A systematic review of the literature. ( 29949680 )
2018
8
Study protocol for a self-controlled cluster randomised trial of the Alert Program to improve self-regulation and executive function in Australian Aboriginal children with fetal alcohol spectrum disorder. ( 29581212 )
2018
9
Ethical aspects of diagnosis and interventions for children with fetal alcohol Spectrum disorder (FASD) and their families. ( 29304784 )
2018
10
Benefits of caseload midwifery to prevent fetal alcohol spectrum disorder: A discussion paper. ( 29602689 )
2018
11
Correction: <i>Fetal alcohol spectrum disorder and youth justice: a prevalence study among young people sentenced to detention in Western Australia</i>. ( 29654055 )
2018
12
Fetal Alcohol Spectrum Disorder and the criminal justice system: A systematic literature review. ( 29548503 )
2018
13
Special issue on fetal alcohol spectrum disorder. ( 29634293 )
2018
14
Mathematics intervention for children with fetal alcohol spectrum disorder: A replication and extension of the math interactive learning experience (MILE) program. ( 29775869 )
2018
15
A Brief History of Awareness of the Link Between Alcohol and Fetal Alcohol Spectrum Disorder. ( 29807454 )
2018
16
Neurocognitive functioning in young offenders with Fetal Alcohol Spectrum Disorder. ( 29724514 )
2018
17
Global Prevalence of Fetal Alcohol Spectrum Disorder in Italy. ( 29582047 )
2018
18
Physiological self-regulation and mindfulness in children with a diagnosis of fetal alcohol spectrum disorder. ( 29634386 )
2018
19
A global research collaboration on fetal alcohol spectrum disorder. ( 29634353 )
2018
20
Deferred diagnosis in children assessed for fetal alcohol spectrum disorder. ( 29432031 )
2018
21
Addressing the public health concerns of Fetal Alcohol Spectrum Disorder: Impact of stigma and health literacy. ( 29477086 )
2018
22
Regional patterns of alcohol-induced neuronal loss depend on genetics: Implications for fetal alcohol spectrum disorder. ( 29957842 )
2018
23
The Standardization of Diagnostic Criteria for Fetal Alcohol Spectrum Disorder (FASD): Implications for Research, Clinical Practice and Population Health. ( 29788774 )
2018
24
The avian embryo as a model for fetal alcohol spectrum disorder. ( 29024604 )
2018
25
Postnatal nutritional treatment of neurocognitive deficits in fetal alcohol spectrum disorder. ( 29091739 )
2018
26
Investigating a theatre-based intervention for Indigenous youth with fetal alcohol spectrum disorder: Exploration d'une intervention basée sur le théâtre auprès de jeunes Autochtones atteints du syndrome d'alcoolisme fœtal. ( 29463135 )
2018
27
Copy number variation in fetal alcohol spectrum disorder. ( 29533680 )
2018
28
Factors predictive of a fetal alcohol spectrum disorder diagnosis: Parent and teacher ratings. ( 29996711 )
2018
29
Fetal Alcohol Spectrum Disorder (FASD): Knowledge, attitudes, experiences and practices of the Western Australian youth custodial workforce. ( 29996987 )
2018
30
An indigenous framework of the cycle of fetal alcohol spectrum disorder risk and prevention across the generations: historical trauma, harm and healing. ( 29999420 )
2018
31
Retinal Wnt signaling defect in a zebrafish fetal alcohol spectrum disorder model. ( 30067812 )
2018
32
Fetal alcohol spectrum disorder in Australia: What is the current state of affairs? ( 30109741 )
2018
33
The past, present, and future of fetal alcohol spectrum disorder work in Newfoundland and Labrador: A landscape paper for change. ( 30198632 )
2018
34
The Role of Integrated Care in a Medical Home for Patients With a Fetal Alcohol Spectrum Disorder. ( 30201625 )
2018
35
A review of interventions against fetal alcohol spectrum disorder targeting oxidative stress. ( 30205148 )
2018
36
Malocclusion Can Give Additional Hints for Diagnosis of Fetal Alcohol Spectrum Disorder. ( 30281068 )
2018
37
Everyday memory difficulties in children and adolescents with Fetal Alcohol Spectrum Disorder. ( 30289318 )
2018
38
Responding to fetal alcohol spectrum disorder in Australia. ( 30294984 )
2018
39
FAST Club: The Impact of a Physical Activity Intervention on Executive Function in Children With Fetal Alcohol Spectrum Disorder. ( 30360635 )
2018
40
A Current Evaluation of the Economic Costs for Fetal Alcohol Spectrum Disorder (FASD): A Comment on the Systematic Review by Greenmeyer et al. ( 30383614 )
2018
41
A Multicountry Updated Assessment of the Economic Impact of Fetal Alcohol Spectrum Disorder: Costs for Children and Adults. ( 30383615 )
2018
42
A systematic review of prevention interventions to reduce prenatal alcohol exposure and fetal alcohol spectrum disorder in indigenous communities. ( 30390661 )
2018
43
Language diversity, language disorder, and fetal alcohol spectrum disorder among youth sentenced to detention in Western Australia. ( 30420110 )
2018
44
Challenges in accurately assessing prenatal alcohol exposure in a study of Fetal Alcohol Spectrum Disorder in a youth detention center. ( 30427546 )
2018
45
Neurodevelopmental outcomes in individuals with fetal alcohol spectrum disorder (FASD) with and without exposure to neglect: Clinical cohort data from a national FASD diagnostic clinic. ( 30544006 )
2018
46
An investigation of intra-individual variability in children with fetal alcohol spectrum disorder (FASD). ( 28301980 )
2018
47
Harnessing neural stem cells for treating psychiatric symptoms associated with fetal alcohol spectrum disorder and epilepsy. ( 28365374 )
2018
48
Age-related differences in neuropsychological assessment of fetal alcohol spectrum disorder: a cross-sectional study. ( 28796950 )
2018
49
Diving into the world of alcohol teratogenesis: a review of zebrafish models of fetal alcohol spectrum disorder. ( 28817785 )
2018
50
Understanding and managing sleep disruption in children with fetal alcohol spectrum disorder. ( 28977761 )
2018

Variations for Fetal Alcohol Spectrum Disorder

Expression for Fetal Alcohol Spectrum Disorder

Search GEO for disease gene expression data for Fetal Alcohol Spectrum Disorder.

Pathways for Fetal Alcohol Spectrum Disorder

Pathways related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.35 BDNF GRIN2A GRIN2B IGF2
2
Show member pathways
12.2 ADH6 ADH7 AKR1A1 ALDH9A1
3
Show member pathways
11.9 ADH6 AKR1A1 ALDH9A1
4
Show member pathways
11.5 BDNF GRIN2A GRIN2B
5
Show member pathways
11.3 ADH6 ADH7 ALDH9A1
6
Show member pathways
11.02 ADH6 ADH7 ALDH9A1
7 10.92 GRIN2A GRIN2B
8 10.9 GRIN2A GRIN2B
9 10.69 GRIN2A GRIN2B
10
Show member pathways
10.29 ADH6 ADH7 AKR1A1

GO Terms for Fetal Alcohol Spectrum Disorder

Cellular components related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synaptic membrane GO:0097060 9.26 GRIN2A GRIN2B
2 postsynaptic density membrane GO:0098839 9.16 GRIN2A GRIN2B
3 synaptic vesicle GO:0008021 9.13 BDNF GRIN2A SV2C
4 NMDA selective glutamate receptor complex GO:0017146 8.62 GRIN2A GRIN2B

Biological processes related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 retinol metabolic process GO:0042572 9.54 ADH7 RBP1
2 ionotropic glutamate receptor signaling pathway GO:0035235 9.52 GRIN2A GRIN2B
3 glutamate receptor signaling pathway GO:0007215 9.51 GRIN2A GRIN2B
4 retinoic acid metabolic process GO:0042573 9.49 ADH7 RBP1
5 striated muscle cell differentiation GO:0051146 9.48 IGF2 SHH
6 activation of cysteine-type endopeptidase activity GO:0097202 9.46 ASPH GRIN2A
7 ethanol oxidation GO:0006069 9.43 ADH6 ADH7
8 oxidation-reduction process GO:0055114 9.43 ADH6 ADH7 AKR1A1 ALDH9A1 ASPH DIO3
9 cellular aldehyde metabolic process GO:0006081 9.4 AKR1A1 ALDH9A1
10 short-term memory GO:0007614 9.37 ADNP CUX2
11 positive regulation of synapse assembly GO:0051965 9.33 ADNP BDNF CUX2
12 excitatory chemical synaptic transmission GO:0098976 9.32 GRIN2A GRIN2B
13 calcium ion transmembrane import into cytosol GO:0097553 9.26 GRIN2A GRIN2B
14 response to ethanol GO:0045471 8.92 ADH6 ADH7 GRIN2A GRIN2B

Molecular functions related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.83 ADH6 ADH7 GRIN2A GRIN2B SHH
2 ionotropic glutamate receptor activity GO:0004970 9.4 GRIN2A GRIN2B
3 retinol binding GO:0019841 9.37 ADH7 RBP1
4 alcohol dehydrogenase (NAD) activity GO:0004022 9.32 ADH6 ADH7
5 NMDA glutamate receptor activity GO:0004972 9.26 GRIN2A GRIN2B
6 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.16 ADH6 ADH7
7 oxidoreductase activity GO:0016491 9.1 ADH6 ADH7 AKR1A1 ALDH9A1 ASPH DIO3
8 glutamate-gated calcium ion channel activity GO:0022849 8.96 GRIN2A GRIN2B

Sources for Fetal Alcohol Spectrum Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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