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FAS
MCID: FTL001
MIFTS: 57

Fetal Alcohol Syndrome (FAS)

Categories: Fetal diseases, Mental diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Fetal Alcohol Syndrome

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MalaCards integrated aliases for Fetal Alcohol Syndrome:

Name: Fetal Alcohol Syndrome 12 74 58 54 15 71 32
Fetal Alcohol Spectrum Disorders 58 42 3 71
Fetus or Newborn Affected by Alcohol Transmitted Via Placenta or Breast Milk 71
Alcohol-Related Neurodevelopmental Disorder 58
Alcohol Related Neurodevelopmental Disorder 71
Alcohol-Related Birth Defects 58
Alcohol Related Birth Defect 71
Arnd 58
Arbd 58
Fasd 58
Fas 58

Characteristics:

Orphanet epidemiological data:

58
fetal alcohol syndrome
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Austria),1-9/100000 (Belgium),1-5/10000 (Germany),1-9/100000 (Hungary),1-9/100000 (Ireland),1-9/100000 (Italy),1-9/100000 (Norway),1-5/10000 (Switzerland),1-9/100000 (United Kingdom),1-5/10000 (France),1-9/1000000 (Poland),1-9/100000 (Spain),6-9/10000 (Ukraine); Age of onset: Antenatal,Neonatal; Age of death: any age;

Classifications:

MalaCards categories:
Global: Fetal diseases Rare diseases
Anatomical: Mental diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Developmental anomalies during embryogenesis
Teratologic disorders


External Ids:

Disease Ontology 12 DOID:0050665
ICD10 32 Q86.0
MESH via Orphanet 44 D005310
ICD10 via Orphanet 33 Q86.0
UMLS via Orphanet 72 C0015923 C0814154 C2985290 more
Orphanet 58 ORPHA1915
UMLS 71 C0015923 C0814154 C1542327 more
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Summaries for Fetal Alcohol Syndrome

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MedlinePlus : 42 Alcohol can harm your baby at any stage during a pregnancy. That includes the earliest stages, before you even know you are pregnant. Drinking during pregnancy can cause a group of conditions called fetal alcohol spectrum disorders (FASDs). Children who are born with FASD can have a mix of problems, such as medical, behavioral, educational, and social problems. The kinds of problems they have depend on which type of FASD they have. The problems could include Abnormal facial features, such as a smooth ridge between the nose and upper lip Small head size Shorter-than-average height Low body weight Poor coordination Hyperactive behavior Difficulty with attention and memory Learning disabilities and difficulty in school Speech and language delays Intellectual disability or low IQ Poor reasoning and judgment skills Sleep and sucking problems as a baby Vision or hearing problems Problems with the heart, kidneys, or bones Fetal alcohol syndrome (FAS) is the most serious type of FASD. People with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. Diagnosing FASD can be hard because there is no specific test for it. The health care provider will make a diagnosis by looking at the child's signs and symptoms and asking whether the mother drank alcohol during pregnancy. FASDs last a lifetime. There is no cure for FASDs, but treatments can help. These include medicines to help with some symptoms, medical care for health problems, behavior and education therapy, and parent training. A good treatment plan is specific to the child's problems. It should include close monitoring, follow-ups, and changes when needed. Certain "protective factors" can help reduce the effects of FASDs and help people who have them reach their full potential. They include Diagnosis before 6 years of age Loving, nurturing, and stable home environment during the school years Absence of violence around them Involvement in special education and social services There is no known safe amount of alcohol during pregnancy. To prevent FASDs, you should not drink alcohol while you are pregnant, or when you might get pregnant. Centers for Disease Control and Prevention

MalaCards based summary : Fetal Alcohol Syndrome, also known as fetal alcohol spectrum disorders, is related to alcohol-related birth defect and renal cell carcinoma, nonpapillary. An important gene associated with Fetal Alcohol Syndrome is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. The drugs Ethanol and Choline have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related phenotypes are intellectual disability and global developmental delay

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

CDC : 3 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose mother drank alcohol during pregnancy. FASDs are preventable if a woman does not drink alcohol during pregnancy.

Wikipedia : 74 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose... more...

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Related Diseases for Fetal Alcohol Syndrome

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Diseases in the Fetal Alcohol Syndrome family:

Fetal Alcohol Spectrum Disorder

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1255)
# Related Disease Score Top Affiliating Genes
1 alcohol-related birth defect 33.2 SLC27A5 PFAS CYP2E1 ADH1B
2 renal cell carcinoma, nonpapillary 32.0 SLC27A5 PVALB MIR9-1 KDM4C H2AC18 CALB2
3 alcohol use disorder 31.5 SLC27A5 KDM4C H2AC18 GRIN2B CYP2E1 BDNF
4 fetal alcohol spectrum disorder 31.3 SLC27A5 PVALB PFAS MIR9-1 KDM4C H2AC18
5 liver cirrhosis 30.8 CYP2E1 ALDH2 AKR1A1 ADH1B
6 mood disorder 30.3 MIR9-1 H2AC18 GFAP BDNF
7 alcohol dependence 30.2 GRIN2B CYP2E1 BDNF ALDH2 AKR1A1 ADH7
8 traumatic brain injury 30.1 GFAP BDNF
9 status epilepticus 30.1 PVALB GRIN2B GFAP CALB2 BDNF
10 disease of mental health 30.1 PVALB MIR9-1 KDM4C H2AC18 GRIN2B BDNF
11 mental depression 30.1 H2AC18 GRIN2B BDNF
12 speech disorder 30.1 PVALB H2AC18 GRIN2B
13 constipation 30.1 VIP H2AC18 CALB2 BDNF
14 drug dependence 30.0 BDNF ADH7 ADH1B
15 substance abuse 30.0 SLC27A5 H2AC18 CYP2E1 BDNF ALDH2 ADH1B
16 scrapie 29.9 PVALB MIR9-1 GFAP
17 grade iii astrocytoma 29.8 KDM4C H2AC18 GFAP
18 amyotrophic lateral sclerosis 1 29.8 PVALB MIR9-1 H2AC18 GFAP CALB2 BDNF
19 alcoholic liver cirrhosis 29.8 CYP2E1 ALDH2 AKR1A1 ADH1B
20 prion disease 29.7 MIR9-1 H2AC18 GFAP
21 gangliocytoma 29.7 PVALB GFAP
22 fragile x syndrome 29.6 PVALB MIR9-1 H2AC18 GRIN2B BDNF
23 psychotic disorder 29.6 SLC27A5 PVALB MIR9-1 H2AC18 GRIN2B BDNF
24 nervous system disease 29.5 MIR9-1 KDM4C H2AC18 BDNF
25 migraine with or without aura 1 29.3 VIP H2AC18 GRIN2B BDNF
26 autism 29.3 KDM4C KCNJ2 GRIN2B GFAP CALB2 BDNF
27 eye disease 29.3 SLC27A5 MIR9-1 KDM4C H2AC18 GFAP BDNF
28 schizophrenia 29.0 PVALB MIR9-1 GRIN2B GFAP CALB2 BDNF
29 pervasive developmental disorder 28.8 PVALB MIR9-1 KDM4C H2AC18 GRIN2B GFAP
30 partial fetal alcohol syndrome 12.8
31 fanconi anemia, complementation group a 12.6
32 autoimmune lymphoproliferative syndrome 12.5
33 friedreich ataxia 12.2
34 graft-versus-host disease 12.0
35 dianzani autoimmune lymphoproliferative disease 11.9
36 adult t-cell leukemia 11.9
37 lung cancer 11.8
38 colorectal cancer 11.7
39 mycosis fungoides 11.7
40 lymphoproliferative syndrome 11.7
41 breast cancer 11.6
42 prostate cancer 11.6
43 ovarian cancer 11.6
44 gastric cancer 11.6
45 caspase 8 deficiency 11.6
46 hepatitis c 11.6
47 lymphoma 11.6
48 autoimmune disease 11.6
49 fanconi anemia, complementation group d2 11.6
50 systemic lupus erythematosus 11.6

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to Fetal Alcohol Syndrome
Sources

Symptoms & Phenotypes for Fetal Alcohol Syndrome

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Human phenotypes related to Fetal Alcohol Syndrome:

58 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intellectual disability 58 31 hallmark (90%) Very frequent (99-80%) HP:0001249
2 global developmental delay 58 31 hallmark (90%) Very frequent (99-80%) HP:0001263
3 behavioral abnormality 58 31 hallmark (90%) Very frequent (99-80%) HP:0000708
4 microcephaly 58 31 hallmark (90%) Very frequent (99-80%) HP:0000252
5 short stature 58 31 hallmark (90%) Very frequent (99-80%) HP:0004322
6 cognitive impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0100543
7 intrauterine growth retardation 58 31 hallmark (90%) Very frequent (99-80%) HP:0001511
8 specific learning disability 58 31 hallmark (90%) Very frequent (99-80%) HP:0001328
9 narrow face 58 31 hallmark (90%) Very frequent (99-80%) HP:0000275
10 telecanthus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000506
11 joint stiffness 58 31 frequent (33%) Frequent (79-30%) HP:0001387
12 short nose 58 31 frequent (33%) Frequent (79-30%) HP:0003196
13 smooth philtrum 58 31 frequent (33%) Frequent (79-30%) HP:0000319
14 anteverted nares 58 31 frequent (33%) Frequent (79-30%) HP:0000463
15 strabismus 58 31 frequent (33%) Frequent (79-30%) HP:0000486
16 microdontia 58 31 frequent (33%) Frequent (79-30%) HP:0000691
17 biparietal narrowing 58 31 frequent (33%) Frequent (79-30%) HP:0004422
18 micrognathia 58 31 frequent (33%) Frequent (79-30%) HP:0000347
19 abnormal dermatoglyphics 58 31 frequent (33%) Frequent (79-30%) HP:0007477
20 epicanthus 58 31 frequent (33%) Frequent (79-30%) HP:0000286
21 ptosis 58 31 frequent (33%) Frequent (79-30%) HP:0000508
22 atrial septal defect 58 31 frequent (33%) Frequent (79-30%) HP:0001631
23 abnormality of immune system physiology 58 31 frequent (33%) Frequent (79-30%) HP:0010978
24 low-set, posteriorly rotated ears 58 31 frequent (33%) Frequent (79-30%) HP:0000368
25 microphthalmia 58 31 frequent (33%) Frequent (79-30%) HP:0000568
26 thin upper lip vermilion 58 31 frequent (33%) Frequent (79-30%) HP:0000219
27 vertebral segmentation defect 58 31 frequent (33%) Frequent (79-30%) HP:0003422
28 visceral angiomatosis 58 31 frequent (33%) Frequent (79-30%) HP:0100761
29 non-midline cleft lip 58 31 frequent (33%) Frequent (79-30%) HP:0100335
30 cleft palate 58 31 occasional (7.5%) Occasional (29-5%) HP:0000175
31 generalized hirsutism 58 31 occasional (7.5%) Occasional (29-5%) HP:0002230
32 congenital diaphragmatic hernia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000776

MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 ADH7 ALDH2 BDNF CALB2 CHRM3 CYP2E1
2 growth/size/body region MP:0005378 9.93 ADH7 AKR1A1 ALDH2 BDNF CHRM3 CYP2E1
3 homeostasis/metabolism MP:0005376 9.77 ADH7 AKR1A1 ALDH2 BDNF CHRM3 CYP2E1
4 mortality/aging MP:0010768 9.44 ADH7 ADNP AKR1A1 ALDH2 BDNF CYP2E1
Sources

Drugs & Therapeutics for Fetal Alcohol Syndrome

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Drugs for Fetal Alcohol Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2, Phase 3 64-17-5 702
2
Choline Approved, Nutraceutical Phase 2, Phase 3 62-49-7 305
3 Neurotransmitter Agents Phase 3
4 Adrenergic Agents Phase 3
5 Atomoxetine Hydrochloride Phase 3
6 Hypolipidemic Agents Phase 2, Phase 3
7 Lipid Regulating Agents Phase 2, Phase 3
8 Gastrointestinal Agents Phase 2, Phase 3
9 Antimetabolites Phase 2, Phase 3
10
Glycerol Approved, Investigational Phase 2 56-81-5 753
11 Protective Agents Phase 2
12
Nicotine Approved 54-11-5 942 89594
13
tannic acid Approved 1401-55-4
14
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
15
Nitric Oxide Approved 10102-43-9 145068
16
leucovorin Approved 58-05-9 6006 143
17
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
18
Epigallocatechin Experimental, Investigational 970-74-1 72277
19
Epigallocatechin gallate Investigational 989-51-5 65064
20
Imidacloprid Vet_approved 105827-78-9 86418
21 Antioxidants
22 Neuroprotective Agents
23 Vitamins
24 Vitamin B Complex
25 Folate
26 Vitamin B9

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 An Open-label Study of the Long Term Tolerability and Safety of Atomoxetine in Treating the Inattention, Impulsivity and Hyperactivity in Children With Fetal-Alcohol Syndrome or Effects. Completed NCT00418262 Phase 3 Atomoxetine
2 A Randomized, Double-Blind, Placebo-controlled Clinical Trial of Choline Supplementation During Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Development Not yet recruiting NCT04395196 Phase 2, Phase 3
3 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
4 Neurocognitive Habilitation for Children With FAS/ARND Completed NCT00164346 Phase 1, Phase 2
5 Fetal Alcohol Syndrome/ARND Research Consortion-Oklahoma Completed NCT00164554 Phase 1, Phase 2
6 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2 Choline bitartrate
7 Study to Investigate the Effectiveness of a Math Intervention for Children With Fetal Alcohol Syndrome or Related Condition Completed NCT00164229 Phase 1, Phase 2
8 A Media Based Motivational Intervention to Reduce Alcohol Exposed Pregnancies (AEPs) Completed NCT00219336 Phase 2
9 Intervening With Children/Adolescents With FAS/ARND Completed NCT00164528 Phase 1, Phase 2
10 Project CHOICES Efficacy Study for Preventing Alcohol-Exposed Pregnancies Completed NCT00153478 Phase 2
11 Assisting Children With Prenatal Alcohol Exposure in Developing Peer Friendships Completed NCT00164307 Phase 1, Phase 2
12 Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Recruiting NCT02735473 Phase 2 Choline bitartrate;Placebo
13 Neighborhood Alcohol & HIV Prevention in South African Townships (Philani) Active, not recruiting NCT00996528 Phase 2
14 A Study of the Efficacy of Atomoxetine in Treating the Inattention, Impulsivity and Hyperactivity in Children With Fetal Alcohol Syndrome or Effects Completed NCT00417794 Phase 1 Strattera;Placebo
15 Computer-delivered SBIRT for Alcohol Use in Pregnancy: Planning a Stage II Trial Completed NCT01643044 Phase 1
16 Prevention of Fetal Alcohol Spectrum Disorder (FASD) by the Use of Technology Unknown status NCT02759874
17 Effects of Hyperbaric Oxygen Therapy on Cognitive Function on Autistic Spectrum Disordered Children Unknown status NCT00631215
18 Development, Implementation, and Evaluation of an Internet-based Behavioural Sleep Intervention for Children With NDD and Insomnia Unknown status NCT02694003
19 Strongest Families FASD: Parent Training for Challenging Behaviour in Children With Fetal Alcohol Spectrum Disorder (FASD) Completed NCT02210455
20 Preventing FAS/ARND in Russian Children Completed NCT01961050
21 Preventing FAS/ARND in Russian Children/Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603
22 Reducing Alcohol Exposed Pregnancy Risk Completed NCT01446653
23 Development of Education Materials for Prevention of Fetal Alcohol Syndrome (FAS) in Russia Completed NCT01971398
24 "Brief Alcohol Intervention: The Healthy Moms Project." Completed NCT00244062
25 Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention Completed NCT02457676
26 Neuromodulation Augmented Cognitive Remediation to Improve Executive Dysfunction in Fetal Alcohol Spectrum Disorder (FASD) Completed NCT03361293
27 Dog-Assisted Therapy for Children and Adolescents With FASD: a Randomized Controlled Pilot Study Completed NCT04038164
28 Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With Fetal Alcohol Spectrum Disorder (FASD) or At-risk for FASD: A Randomized Controlled Field Trial Completed NCT01536184
29 Newborn Phosphatidylethanol Screening to Detect Fetal Alcohol Exposure in Uruguay Completed NCT02600624
30 Prevention of Fetal Alcohol Damage Using Maternal Blood Markers Completed NCT00696085
31 A Randomized Clinical Trial of the Contraception and Alcohol Risk Reduction Internet Intervention to Reduce AEP Risk in Community Women Completed NCT02128880
32 Epigallocatechin Gallate (EGCG) as Therapeutic Tool to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children Completed NCT02558933
33 Early Identification of Affected Children and Nutritional Risk Factors for FASD in Ukraine Completed NCT03782935
34 Self-Regulation in Adolescents With FASD: The Efficacy of a Targeted Intervention Completed NCT02912962
35 Fetal Alcohol Spectrum Disorder-Is This a Ciliopathy? Completed NCT03802708
36 Modeling and Testing Change in Mental Abilities in Childhood Through Computer-based Interventions Completed NCT02459873
37 Effects of Hyperbaric Oxygen Therapy on Clinical Symptoms and Markers of Inflammation and Oxidative Stress in Autistic Children: A Pilot Study Completed NCT00324909 Hyperbaric Oxygen Therapy
38 Face Anthropometric Pattern Recognition Technology, Based on 3D Reconstruction Technology, for Computer Aided Diagnosis of Human Genetic Disorders. Multicenter Collaborative Study. Completed NCT00705055
39 Comprehensive Program for Youth Mental Health Completed NCT02169960
40 A Prospective, Randomized, Double-Blind, Controlled Study on the Clinical Effects of Hyperbaric Therapy in Autistic Children Completed NCT00335790
41 Augmented Biofeedback Training Combined With Physical Therapy Program Improves Visual-motor Integration, Visual Perception and Motor Coordination in Children With Spastic Hemiplegic Cerebral Palsy: a Randomized Control Trial Completed NCT03626077
42 Dissecting the Genetics of Fetal Alcohol Spectrum Disorders Recruiting NCT04072809
43 In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions Recruiting NCT03371641
44 Feasibility Trial of the FMF Connect Mobile Health Intervention Recruiting NCT04194489
45 The Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Life Span: Continuing Prevention and Longitudinal Epidemiology Recruiting NCT04026620
46 Parent Emotion Socialization and Child Emotion Regulation in FASD Recruiting NCT03524664
47 Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum Disorder Recruiting NCT03494738
48 Preventing Alcohol Exposed Pregnancy Among Urban Native Young Women: Mobile CHOICES Recruiting NCT04376346
49 Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial Recruiting NCT03342495
50 Native-Changing High-risk Alcohol Use and Increasing Contraception Effectiveness Study Recruiting NCT03930342

Search NIH Clinical Center for Fetal Alcohol Syndrome

Sources

Genetic Tests for Fetal Alcohol Syndrome

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Anatomical Context for Fetal Alcohol Syndrome

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MalaCards organs/tissues related to Fetal Alcohol Syndrome:

40
Brain, Eye, Testes, Cortex, Heart, Bone, Placenta
Sources

Publications for Fetal Alcohol Syndrome

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Articles related to Fetal Alcohol Syndrome:

(show top 50) (show all 3063)
# Title Authors PMID Year
1
Neurodevelopmental Outcomes Associated with Prefrontal Cortical Deoxygenation in Children with Fetal Alcohol Spectrum Disorders. 61 42
31914808 2020
2
Fetal Alcohol Spectrum Disorder: Embryogenesis Under Reduced Retinoic Acid Signaling Conditions. 42
32297301 2020
3
Looking back, moving forward: 50 years of South African Medical Research Council alcohol-related publications. 42
32252865 2019
4
Effect of gestational ethanol exposure on parvalbumin and calretinin expressing hippocampal neurons in a chick model of fetal alcohol syndrome. 54 61
19251116 2009
5
Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview. 54 61
17618743 2007
6
The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome. 61 54
7748347 1993
7
A hypothetical mechanism for fetal alcohol syndrome involving ethanol inhibition of retinoic acid synthesis at the alcohol dehydrogenase step. 61 54
1877746 1991
8
A review of studies exploring fetal alcohol spectrum disorders through eye tracking measures. 61
32470497 2020
9
Proceedings of the 2019 annual meeting of the Fetal Alcohol Spectrum Disorders Study Group. 61
32171771 2020
10
A randomized controlled trial of transcranial direct-current stimulation and cognitive training in children with fetal alcohol spectrum disorder. 61
32360392 2020
11
Sleep disturbance as a predictor of anxiety in children with Fetal Alcohol Spectrum Disorders and typically developing children. 61
32224364 2020
12
Moderate prenatal alcohol exposure alters the number and function of GABAergic interneurons in the murine orbitofrontal cortex. 61
32540413 2020
13
Short Exposure to Moderate Concentration of Alcohol During Embryonic Development Does Not Alter Gross Morphology in Zebrafish. 61
32493176 2020
14
Ophthalmologic Findings in Fetal Alcohol Spectrum Disorders - A Cohort Study From Childhood to Adulthood. 61
31926885 2020
15
Incontinence in persons with fetal alcohol spectrum disorders: a polish cohort. 61
32222270 2020
16
Chronic Binge Alcohol Exposure During Pregnancy Alters mTOR System in Rat Fetal Hippocampus. 61
32333810 2020
17
Fetal alcohol spectrum disorder among pre-adopted and foster children. 61
32493264 2020
18
Strengthening the impairment argument against abortion. 61
32503928 2020
19
Characterizing Alcohol-Related Neurodevelopmental Disorder: Prenatal Alcohol Exposure and the Spectrum of Outcomes. 61
32173870 2020
20
Hippocampal transcriptome analysis following maternal separation implicates altered RNA processing in a mouse model of fetal alcohol spectrum disorder. 61
32416732 2020
21
Rescue of ethanol-induced FASD-like phenotypes via prenatal co-administration of choline. 61
32044264 2020
22
Single-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens. 61
32251710 2020
23
Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. 61
32202514 2020
24
Postnatal Ethanol-Induced Neurodegeneration Involves CB1R-Mediated β-Catenin Degradation in Neonatal Mice. 61
32370076 2020
25
Early Ethanol Exposure Inhibits the Differentiation of Hippocampal Dentate Gyrus Granule Cells in a Mouse Model of Fetal Alcohol Spectrum Disorders. 61
32220014 2020
26
Corrigendum: Graded Cerebellar Lobular Volume Deficits in Adolescents and Young Adults with Fetal Alcohol Spectrum Disorders (FASD). 61
32249891 2020
27
Motor performance and sensory processing behaviors among children with fetal alcohol spectrum disorders compared to children with developmental coordination disorders. 61
32446153 2020
28
Fetal alcohol spectrum disorders: Genetic and epigenetic mechanisms. 61
32386259 2020
29
Maternal alcohol consumption during pregnancy associates with bone fractures in early childhood. A birth-cohort study of 6718 participants. 61
32485362 2020
30
Fetus morphology changes by second-trimester ultrasound in pregnant women drinking alcohol. 61
30811093 2020
31
Postnatal Ethanol Exposure Activates HDAC-Mediated Histone Deacetylation, Impairs Synaptic Plasticity Gene Expression and Behavior in Mice. 61
32170298 2020
32
Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. 61
32173352 2020
33
Folic acid supplement rescues ethanol-induced developmental defects in the zebrafish embryos. 61
32369106 2020
34
Prevalence and patterns of sensory processing behaviors in a large clinical sample of children with prenatal alcohol exposure. 61
32203885 2020
35
Morphological changes of the dorsal contour of the corpus callosum during the first two years of life. 61
31840188 2020
36
Fetal Alcohol Spectrum Disorders in a Rocky Mountain Region City: Child Characteristics, Maternal Risk Traits, and Prevalence. 61
32293732 2020
37
Neurodevelopment in adolescents and adults with fetal alcohol spectrum disorders (FASD): A magnetic resonance region of interest analysis. 61
31930998 2020
38
Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders. 61
32203497 2020
39
Hydrogen Sulfide Attenuates the Neurotoxicity in the Animal Model of Fetal Alcohol Spectrum Disorders. 61
31900896 2020
40
A Mobile Health Intervention for Fetal Alcohol Spectrum Disorders (Families Moving Forward Connect): Development and Qualitative Evaluation of Design and Functionalities. 61
32250274 2020
41
Increased Notching of the Corpus Callosum in Fetal Alcohol Spectrum Disorder: A Callosal Misunderstanding? 61
32193189 2020
42
Nerve Growth Factor in Alcohol Use Disorders. 61
32348226 2020
43
Prenatal Drinking in the Northern Plains: Differences Between American Indian and Caucasian Mothers. 61
32061456 2020
44
Mental health outcomes among parents of a child who has a developmental disability: Comparing different types of developmental disability. 61
31796336 2020
45
Alcohol use in young adults associated with cortical gyrification. 61
32088591 2020
46
18q12.3-q21.1 microdeletion detected in the prenatally alcohol-exposed dizygotic twin with discordant fetal alcohol syndrome phenotype. 61
32096599 2020
47
Reduced Hippocampal Volumes Partially Mediate Effects of Prenatal Alcohol Exposure on Spatial Navigation on a Virtual Water Maze Task in Children. 61
32196695 2020
48
Fetal Alcohol Spectrum Disorders in a Southeastern County of the United States: Child Characteristics and Maternal Risk Traits. 61
32293734 2020
49
Fetal Alcohol Spectrum Disorders in a Midwestern City: Child Characteristics, Maternal Risk Traits, and Prevalence. 61
32293735 2020
50
Animal models of gene-alcohol interactions. 61
31774246 2020
Sources

Variations for Fetal Alcohol Syndrome

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Expression for Fetal Alcohol Syndrome

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Search GEO for disease gene expression data for Fetal Alcohol Syndrome.
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Pathways for Fetal Alcohol Syndrome

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Pathways related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Cytochrome P450 - arranged by substrate type 65
Show member pathways
 12.97 CYP2E1 ALDH2 AKR1A1 ADH7 ADH1B ADH1A
2
Drug metabolism - cytochrome P450 36
Show member pathways
 12.53 CYP2E1 ALDH2 ADH7 ADH1B ADH1A
3
Fatty Acyl-CoA Biosynthesis 65
Show member pathways
 12.21 ALDH2 ADH7 ADH1B ADH1A
4
Glucose metabolism 65
Show member pathways
 12.13 ALDH2 AKR1A1 ADH7 ADH1B ADH1A
5
superpathway of tryptophan utilization 1
Show member pathways
 11.47 ALDH2 AKR1A1 ADH1B
6
Tyrosine metabolism 36
Show member pathways
 11.31 ADH7 ADH1B ADH1A
7
noradrenaline and adrenaline degradation 1
Show member pathways
 10.68 ALDH2 ADH1B
8
Abacavir Pathway, Pharmacokinetics/Pharmacodynamics 60
10.55 ADH1B ADH1A
9
Cyclophosphamide Pathway, Pharmacodynamics 60
Show member pathways
 10.51 ALDH2 AKR1A1 ADH7 ADH1B ADH1A
10
acetone degradation I (to methylglyoxal) 1
Show member pathways
 10.36 CYP2E1 ADH1B
11
ethanol degradation II 1
Show member pathways
 10.31 CYP2E1 ALDH2 ADH1B
Sources

GO Terms for Fetal Alcohol Syndrome

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Cellular components related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.35 KCNJ2 CHRM3 CALB2 BDNF ADNP
2 cuticular plate GO:0032437 8.62 PVALB CALB2

Biological processes related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.61 GRIN2B CYP2E1 ADH7
2 oxidation-reduction process GO:0055114 9.56 SLC27A5 KDM4C CYP2E1 ALDH2 AKR1A1 ADH7
3 learning or memory GO:0007611 9.54 VIP GRIN2B BDNF
4 retinol metabolic process GO:0042572 9.43 ADH7 ADH1B ADH1A
5 ethanol catabolic process GO:0006068 9.4 ALDH2 ADH7
6 retinoic acid metabolic process GO:0042573 9.33 ADH7 ADH1B ADH1A
7 alcohol metabolic process GO:0006066 9.32 ALDH2 ADH1A
8 ethanol oxidation GO:0006069 8.92 ALDH2 ADH7 ADH1B ADH1A

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.56 SLC27A5 KDM4C CYP2E1 ALDH2 AKR1A1 ADH7
2 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.33 ADH7 ADH1B ADH1A
3 alcohol dehydrogenase (NAD) activity GO:0004022 9.26 ADH7 ADH1A
4 retinol dehydrogenase activity GO:0004745 8.92 AKR1A1 ADH7 ADH1B ADH1A
Sources

Sources for Fetal Alcohol Syndrome

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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