FAS
MCID: FTL001
MIFTS: 63

Fetal Alcohol Syndrome (FAS)

Categories: Fetal diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Fetal Alcohol Syndrome

MalaCards integrated aliases for Fetal Alcohol Syndrome:

Name: Fetal Alcohol Syndrome 12 76 59 55 15 73
Fetal Alcohol Spectrum Disorders 59 73
Fetus or Newborn Affected by Alcohol Transmitted Via Placenta or Breast Milk 73
Alcohol-Related Neurodevelopmental Disorder 59
Alcohol Related Neurodevelopmental Disorder 73
Alcohol-Related Birth Defects 59
Alcohol Related Birth Defect 73
Arnd 59
Arbd 59
Fasd 59
Fas 59

Characteristics:

Orphanet epidemiological data:

59
fetal alcohol syndrome
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Austria),1-9/100000 (Belgium),1-5/10000 (Germany),1-9/100000 (Hungary),1-9/100000 (Ireland),1-9/100000 (Italy),1-9/100000 (Norway),1-5/10000 (Switzerland),1-9/100000 (United Kingdom),1-5/10000 (France),1-9/1000000 (Poland),1-9/100000 (Spain),6-9/10000 (Ukraine); Age of onset: Antenatal,Neonatal; Age of death: any age;

Classifications:



Summaries for Fetal Alcohol Syndrome

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

MalaCards based summary : Fetal Alcohol Syndrome, also known as fetal alcohol spectrum disorders, is related to fetal alcohol spectrum disorder and ocular dominance. An important gene associated with Fetal Alcohol Syndrome is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Glucose metabolism and Dopamine-DARPP32 Feedback onto cAMP Pathway. The drugs Ethanol and Epigallocatechin have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and placenta, and related phenotypes are ptosis and intellectual disability

CDC : 3 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose mother drank alcohol during pregnancy. FASDs are completely preventable if a woman does not drink alcohol during pregnancy.

Wikipedia : 76 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose... more...

Related Diseases for Fetal Alcohol Syndrome

Diseases in the Fetal Alcohol Syndrome family:

Fetal Alcohol Spectrum Disorder

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 612)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol spectrum disorder 31.9 ADH7 ADNP AKR1A1 GRIN2A GRIN2B PFAS
2 ocular dominance 29.9 GRIN2A GRIN2B
3 disease of mental health 29.5 GRIN2A GRIN2B PVALB
4 autism 29.1 ADNP GRIN2A GRIN2B PVALB
5 alcohol dependence 28.9 ADH1B ADH7 AKR1A1 ALDH2 GRIN2A GRIN2B
6 partial fetal alcohol syndrome 12.6
7 autoimmune lymphoproliferative syndrome 12.3
8 fanconi anemia, complementation group a 12.2
9 alcohol-related birth defect 12.2
10 friedreich ataxia 1 11.7
11 dianzani autoimmune lymphoproliferative disease 11.6
12 lung cancer 11.6
13 colorectal cancer 11.6
14 lymphoproliferative syndrome 11.6
15 squamous cell carcinoma 11.5
16 prostate cancer 11.5
17 silicosis 11.5
18 graft-versus-host disease 11.5
19 viral hepatitis 11.4
20 autoimmune hepatitis 11.4
21 lymphopenia 11.4
22 hashimoto thyroiditis 11.4
23 systemic lupus erythematosus 11.4
24 autoimmune disease 11.4
25 b-cell lymphomas 11.4
26 alzheimer disease 11.4
27 graves' disease 11.4
28 diabetes mellitus 11.4
29 severe cutaneous adverse reaction 11.4
30 myelodysplastic syndrome 11.4
31 burkitt lymphoma 11.4
32 aplastic anemia 11.4
33 asthma 11.4
34 pneumoconiosis 11.4
35 burn scar 11.4
36 keloids 11.4
37 adult t-cell leukemia 11.3
38 leukemia, chronic lymphocytic 11.3
39 common variable immunodeficiency 11.3
40 breast adenocarcinoma 11.3
41 kashin-beck disease 11.3
42 gastric adenocarcinoma 11.3
43 persistent polyclonal b-cell lymphocytosis 11.3
44 autoimmune lymphoproliferative syndrome, type v 11.3
45 acute myocarditis 11.3
46 stevens-johnson syndrome/toxic epidermal necrolysis 11.3
47 type ii mixed cryoglobulinemia 11.3
48 cartilage-hair hypoplasia 11.3
49 lymphoma, non-hodgkin, familial 11.3
50 ewing sarcoma 11.3

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to Fetal Alcohol Syndrome

Symptoms & Phenotypes for Fetal Alcohol Syndrome

Human phenotypes related to Fetal Alcohol Syndrome:

59 32 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 59 32 frequent (33%) Frequent (79-30%) HP:0000508
2 intellectual disability 59 32 hallmark (90%) Very frequent (99-80%) HP:0001249
3 behavioral abnormality 59 32 hallmark (90%) Very frequent (99-80%) HP:0000708
4 global developmental delay 59 32 hallmark (90%) Very frequent (99-80%) HP:0001263
5 joint stiffness 59 32 frequent (33%) Frequent (79-30%) HP:0001387
6 short nose 59 32 frequent (33%) Frequent (79-30%) HP:0003196
7 microcephaly 59 32 hallmark (90%) Very frequent (99-80%) HP:0000252
8 smooth philtrum 59 32 frequent (33%) Frequent (79-30%) HP:0000319
9 anteverted nares 59 32 frequent (33%) Frequent (79-30%) HP:0000463
10 short stature 59 32 hallmark (90%) Very frequent (99-80%) HP:0004322
11 cognitive impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0100543
12 cleft palate 59 32 occasional (7.5%) Occasional (29-5%) HP:0000175
13 micrognathia 59 32 frequent (33%) Frequent (79-30%) HP:0000347
14 strabismus 59 32 frequent (33%) Frequent (79-30%) HP:0000486
15 epicanthus 59 32 frequent (33%) Frequent (79-30%) HP:0000286
16 generalized hirsutism 59 32 occasional (7.5%) Occasional (29-5%) HP:0002230
17 microdontia 59 32 frequent (33%) Frequent (79-30%) HP:0000691
18 biparietal narrowing 59 32 frequent (33%) Frequent (79-30%) HP:0004422
19 intrauterine growth retardation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001511
20 specific learning disability 59 32 hallmark (90%) Very frequent (99-80%) HP:0001328
21 abnormal dermatoglyphics 59 32 frequent (33%) Frequent (79-30%) HP:0007477
22 atrial septal defect 59 32 frequent (33%) Frequent (79-30%) HP:0001631
23 abnormality of immune system physiology 59 32 frequent (33%) Frequent (79-30%) HP:0010978
24 telecanthus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000506
25 non-midline cleft lip 59 32 frequent (33%) Frequent (79-30%) HP:0100335
26 microphthalmia 59 32 frequent (33%) Frequent (79-30%) HP:0000568
27 visceral angiomatosis 59 32 frequent (33%) Frequent (79-30%) HP:0100761
28 low-set, posteriorly rotated ears 59 32 frequent (33%) Frequent (79-30%) HP:0000368
29 narrow face 59 32 hallmark (90%) Very frequent (99-80%) HP:0000275
30 thin upper lip vermilion 59 32 frequent (33%) Frequent (79-30%) HP:0000219
31 vertebral segmentation defect 59 32 frequent (33%) Frequent (79-30%) HP:0003422
32 congenital diaphragmatic hernia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000776

MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ADH7 ALDH2 CHRM3 GFAP GRIN2A GRIN2B
2 growth/size/body region MP:0005378 9.97 ADH7 AKR1A1 ALDH2 CHRM3 GFAP GRIN2B
3 homeostasis/metabolism MP:0005376 9.91 ADH7 AKR1A1 ALDH2 CHRM3 GFAP GRIN2B
4 mortality/aging MP:0010768 9.85 ADH7 ADNP AKR1A1 ALDH2 GFAP GRIN2B
5 nervous system MP:0003631 9.61 ADH7 ADNP ALDH2 CHRM3 GFAP GRIN2A
6 vision/eye MP:0005391 9.17 ALDH2 CHRM3 GFAP PFAS PVALB RBP1

Drugs & Therapeutics for Fetal Alcohol Syndrome

Drugs for Fetal Alcohol Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
2
Epigallocatechin Experimental, Investigational Phase 2, Phase 3 970-74-1 72277
3
Epigallocatechin gallate Investigational Phase 2, Phase 3 989-51-5 65064
4 Antioxidants Phase 2, Phase 3
5 Protective Agents Phase 2, Phase 3
6 Neuroprotective Agents Phase 2, Phase 3
7 Anti-Infective Agents, Local Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
8 Central Nervous System Depressants Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
9 Anti-Infective Agents Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
10 Neurotransmitter Agents Phase 3,Phase 1
11 Atomoxetine Hydrochloride Phase 3,Phase 1
12 Neurotransmitter Uptake Inhibitors Phase 3,Phase 1
13 Adrenergic Agents Phase 3,Phase 1
14
Choline Approved, Nutraceutical Phase 2,Phase 1 62-49-7 305
15 Nootropic Agents Phase 2,Phase 1
16 Lipid Regulating Agents Phase 2,Phase 1
17 Antimetabolites Phase 2,Phase 1
18 Gastrointestinal Agents Phase 2,Phase 1
19 Hypolipidemic Agents Phase 2,Phase 1
20
Nicotine Approved Not Applicable 54-11-5 942 89594
21 tannic acid Approved Not Applicable
22
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Epigallocatechin Gallate (EGCG) to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children Unknown status NCT02558933 Phase 2, Phase 3
2 Open-Label Study of the Long Term Tolerability and Safety of Atomoxetine in Children With FASD and ADD/ADHD Completed NCT00418262 Phase 3 Atomoxetine
3 Fetal Alcohol Syndrome/ARND Research Consortion Completed NCT00164554 Phase 1, Phase 2
4 Fetal Alcohol Syndrome: Socio-Cognitive Habilitation Completed NCT00164229 Phase 1, Phase 2
5 Neurocognitive Habilitation for Children With Fetal Alcohol Syndrome (FAS)/Alcohol-Related Neurodevelopmental Disorder (ARND) Completed NCT00164346 Phase 1, Phase 2
6 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
7 A Media Based Motivational Intervention to Prevent Alcohol Exposed Pregnancies (AEPs) Completed NCT00219336 Phase 2
8 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2 Choline bitartrate
9 Project CHOICES Efficacy Study Completed NCT00153478 Phase 2
10 Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Recruiting NCT02735473 Phase 2 Choline bitartrate;Placebo
11 Neighborhood Alcohol & HIV Prevention in South African Townships (Philani) Active, not recruiting NCT00996528 Phase 2
12 Assess the Effectiveness of Atomoxetine in Children With Fetal Alcohol Syndrome and ADD/ADHD Completed NCT00417794 Phase 1 Strattera;Placebo
13 Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention Completed NCT02457676 Not Applicable
14 Development of Education Materials for Prevention of FAS in Russia Completed NCT01971398 Not Applicable
15 Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With FASD Completed NCT01536184 Not Applicable
16 Parenting Training for Children With FASD Completed NCT02210455 Not Applicable
17 Contraception and Alcohol Risk Reduction Internet Intervention Randomized Trial Completed NCT02128880 Not Applicable
18 Preventing FAS/ARND in Russian Children Completed NCT01961050 Not Applicable
19 Nutritional Risk Factors for FASD in Ukraine Completed NCT03782935 Not Applicable
20 Self-Regulation in Adolescents With FASD: The Efficacy of a Targeted Intervention Completed NCT02912962 Not Applicable
21 Fetal Alcohol Damage Prevention Study Completed NCT00696085 Not Applicable
22 Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603 Not Applicable
23 Healthy Moms Alcohol Intervention Completed NCT00244062 Not Applicable
24 Effects of Hyperbaric Oxygen Therapy in Autistic Children: A Pilot Study Completed NCT00324909 Not Applicable Hyperbaric Oxygen Therapy
25 Comprehensive Program for Youth Mental Health Completed NCT02169960 Not Applicable
26 Modeling and Testing Change in Mental Abilities in Childhood Completed NCT02459873 Not Applicable
27 Reducing Alcohol Exposed Pregnancy Risk: EARLY Randomized Controlled Trial Completed NCT01446653 Not Applicable
28 Fetal Alcohol Spectrum Disorder-Is This a Ciliopathy? Recruiting NCT03802708 Not Applicable
29 A Study of Parent and Child Emotions in Fetal Alcohol Spectrum Disorder (FASD) Recruiting NCT03524664 Not Applicable
30 Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum Disorder Recruiting NCT03494738
31 Cognitive Training and tDCS for Children With FASD Recruiting NCT03361293 Not Applicable
32 In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions Recruiting NCT03371641 Not Applicable
33 Prenatal Alcohol Biomarker Study in Uruguay Recruiting NCT02600624
34 Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial Recruiting NCT03342495 Not Applicable
35 Effects of Prenatal Alcohol Exposure on Emotional and Cognitive Abilities in Adults Active, not recruiting NCT03793920 Not Applicable
36 Prevention of Fetal Alcohol Spectrum Disorder (FASD) by the Use of Technology Enrolling by invitation NCT02759874 Not Applicable
37 Better Nights, Better Days for Children With Neurodevelopment Disorders Not yet recruiting NCT02694003 Not Applicable
38 Evaluating the Efficacy of a Video Based Intervention to Educate Teen Moms About Fetal Alcohol Syndrome (FAS) Terminated NCT00747630 Early Phase 1

Search NIH Clinical Center for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

Anatomical Context for Fetal Alcohol Syndrome

MalaCards organs/tissues related to Fetal Alcohol Syndrome:

41
Brain, Eye, Placenta, Breast, Liver, Testes, Kidney

Publications for Fetal Alcohol Syndrome

Articles related to Fetal Alcohol Syndrome:

(show top 50) (show all 1225)
# Title Authors Year
1
Recognition of clinical characteristics for population-based surveillance of fetal alcohol syndrome. ( 29368410 )
2018
2
Genetic predisposition to fetal alcohol syndrome: association with congenital disorders of N-glycosylation. ( 28820871 )
2018
3
Effects of ethanol and varenicline on female Sprague-Dawley rats in a third trimester model of fetal alcohol syndrome. ( 30059955 )
2018
4
Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology. ( 30068419 )
2018
5
Comparing diagnostic outcomes of children with fetal alcohol syndrome in South Africa with diagnostic outcomes when using the updated Institute of Medicine diagnostic guidelines. ( 30347134 )
2018
6
Erratum to: "Functional MRI of Human Eyeblink Classical Conditioning in Children with Fetal Alcohol Spectrum Disorders". ( 28334243 )
2018
7
Fetal alcohol spectrum disorders: Zebrafish in the analysis of the milder and more prevalent form of the disease. ( 28988969 )
2018
8
GoFAR: improving attention, behavior and adaptive functioning in children with fetal alcohol spectrum disorders: Brief report. ( 29313400 )
2018
9
Challenges of diagnosing fetal alcohol spectrum disorders in foster and adopted children. ( 29316477 )
2018
10
An Environmental Scan of the Role of Nurses in Preventing Fetal Alcohol Spectrum Disorders. ( 29370546 )
2018
11
Screening and brief intervention to prevent fetal alcohol spectrum disorders. ( 29384835 )
2018
12
Implications of Higher Than Expected Prevalence of Fetal Alcohol Spectrum Disorders. ( 29411016 )
2018
13
Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities. ( 29411031 )
2018
14
Screening and brief intervention to prevent fetal alcohol spectrum disorders. ( 29465524 )
2018
15
Experiences of living with fetal alcohol spectrum disorders: a systematic review and synthesis of qualitative data. ( 29479676 )
2018
16
Effectiveness of evidence-based treatments of fetal alcohol spectrum disorders in children and adolescents: a systematic review protocol. ( 29525767 )
2018
17
Proceedings of the 2017 annual meeting of the Fetal Alcohol Spectrum Disorders study group. ( 29550584 )
2018
18
Fetal alcohol spectrum disorders (FASD) - What we know and what we should know - The knowledge of German health professionals and parents. ( 29551660 )
2018
19
Have we done enough for people with fetal alcohol spectrum disorders? ( 29569352 )
2018
20
The contributions of Dr. Kathleen K. Sulik to fetal alcohol spectrum disorders research and prevention. ( 29571046 )
2018
21
A modified Delphi study towards developing a guideline to inform policy on fetal alcohol spectrum disorders in South Africa: a study protocol. ( 29703853 )
2018
22
Amplitude by Peak Interaction but No Evidence of Auditory Mismatch Response Deficits to Frequency Change in Preschool-Aged Children with Fetal Alcohol Spectrum Disorders. ( 29797565 )
2018
23
Review and gap analysis: molecular pathways leading to fetal alcohol spectrum disorders. ( 29892052 )
2018
24
Nonprotein-coding RNAs in Fetal Alcohol Spectrum Disorders. ( 29933954 )
2018
25
Combined Face-Brain Morphology and Associated Neurocognitive Correlates in Fetal Alcohol Spectrum Disorders. ( 29935097 )
2018
26
Moderate developmental alcohol exposure reduces repetitive alternation in a zebrafish model of fetal alcohol spectrum disorders. ( 30201482 )
2018
27
Comparisons of the BRIEF parental report and neuropsychological clinical tests of executive function in Fetal Alcohol Spectrum Disorders: data from the UK national specialist clinic. ( 30251596 )
2018
28
White matter microstructure in fetal alcohol spectrum disorders: A systematic review of diffusion tensor imaging studies. ( 30289588 )
2018
29
Speech Impairment in Boys With Fetal Alcohol Spectrum Disorders. ( 30398563 )
2018
30
Coordinated Tcf7l2 regulation in a mouse model implicates Wnt signaling in Fetal Alcohol Spectrum Disorders. ( 30398926 )
2018
31
Exploring service providers' perspectives on the prevention and management of fetal alcohol spectrum disorders in South Africa: a qualitative study. ( 30400900 )
2018
32
Screening prevalence of fetal alcohol spectrum disorders in a region of the United Kingdom: A population-based birth-cohort study. ( 30503408 )
2018
33
<i>Xenopus</i> embryos to study Fetal Alcohol Syndrome, a model for environmental teratogenesis. ( 29069552 )
2017
34
Fetal Alcohol Syndrome and Fetal Alcohol Spectrum Disorders. ( 29094891 )
2017
35
Differences in neural crest sensitivity to ethanol account for the infrequency of anterior segment defects in the eye compared with craniofacial anomalies in a zebrafish model of fetal alcohol syndrome. ( 28681995 )
2017
36
Unreliable estimation of prevalence of fetal alcohol syndrome. ( 28495259 )
2017
37
Unreliable estimation of prevalence of fetal alcohol syndrome. ( 28495260 )
2017
38
Unreliable estimation of prevalence of fetal alcohol syndrome - Authors' reply. ( 28495261 )
2017
39
Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis. ( 28089487 )
2017
40
Competition between ethanol clearance and retinoic acid biosynthesis in the induction of Fetal Alcohol Syndrome. ( 28982012 )
2017
41
Digital assessment of the fetal alcohol syndrome facial phenotype: reliability and agreement study. ( 29637153 )
2017
42
The Prevalence of Fetal Alcohol Syndrome and Its Impact on a Child's Classroom Performance: A Case Study of a Rural South African School. ( 28792446 )
2017
43
Fetal Alcohol Syndrome Disorder: diminished responsibility and mitigation of sentence. ( 28699765 )
2017
44
A Rat Model of Fetal Alcohol Syndrome: A Series of Undergraduate Laboratory Exercises for Biopsychology Courses. ( 28690436 )
2017
45
Fetal Alcohol Syndrome ( 28846263 )
2017
46
High global prevalence of alcohol use during pregnancy and fetal alcohol syndrome indicates need for urgent action. ( 28089488 )
2017
47
'Too Young To Drink'. An international communication campaign to raise public awareness of fetal alcohol spectrum disorders. ( 27600792 )
2017
48
Correlation between morphological MRI findings and specific diagnostic categories in fetal alcohol spectrum disorders. ( 27620364 )
2017
49
Seizures and electroencephalography findings in 61 patients with fetal alcohol spectrum disorders. ( 27638326 )
2017
50
Prevalence of alcohol consumption during pregnancy and Fetal Alcohol Spectrum Disorders among the general and Aboriginal populations in Canada and the United States. ( 27638329 )
2017

Variations for Fetal Alcohol Syndrome

Expression for Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for Fetal Alcohol Syndrome

Pathways related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.25 ADH1B ADH7 AKR1A1 ALDH2
2 12.04 GRIN2A GRIN2B KCNJ2
3 11.99 GFAP GRIN2A GRIN2B VIP
4
Show member pathways
11.85 ADH1B AKR1A1 ALDH2
5 11.1 GRIN2A GRIN2B
6
Show member pathways
11.1 ADH1B ADH7 ALDH2
7 10.94 GRIN2A GRIN2B
8 10.92 GRIN2A GRIN2B
9 10.73 GRIN2A GRIN2B
10
Show member pathways
10.5 ADH1B ALDH2
11
Show member pathways
10.43 ADH1B ALDH2
12
Show member pathways
10.42 ADH1B ADH7 AKR1A1 ALDH2

GO Terms for Fetal Alcohol Syndrome

Cellular components related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.56 AKR1A1 CHRM3 GRIN2A GRIN2B
2 synaptic membrane GO:0097060 9.16 GRIN2A GRIN2B
3 postsynaptic density membrane GO:0098839 8.96 GRIN2A GRIN2B
4 NMDA selective glutamate receptor complex GO:0017146 8.62 GRIN2A GRIN2B

Biological processes related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.63 ADH7 GRIN2A GRIN2B
2 regulation of sensory perception of pain GO:0051930 9.51 GRIN2A VIP
3 retinol metabolic process GO:0042572 9.49 ADH7 RBP1
4 ionotropic glutamate receptor signaling pathway GO:0035235 9.48 GRIN2A GRIN2B
5 glutamate receptor signaling pathway GO:0007215 9.43 GRIN2A GRIN2B
6 retinoic acid metabolic process GO:0042573 9.4 ADH7 RBP1
7 ethanol catabolic process GO:0006068 9.37 ADH7 ALDH2
8 learning or memory GO:0007611 9.33 GRIN2A GRIN2B VIP
9 excitatory chemical synaptic transmission GO:0098976 9.32 GRIN2A GRIN2B
10 calcium ion transmembrane import into cytosol GO:0097553 9.26 GRIN2A GRIN2B
11 long-term synaptic potentiation GO:0060291 9.13 GFAP GRIN2A GRIN2B
12 ethanol oxidation GO:0006069 8.8 ADH1B ADH7 ALDH2

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.67 ADH1B ADH7 AKR1A1 ALDH2
2 ionotropic glutamate receptor activity GO:0004970 9.32 GRIN2A GRIN2B
3 retinol binding GO:0019841 9.26 ADH7 RBP1
4 NMDA glutamate receptor activity GO:0004972 9.16 GRIN2A GRIN2B
5 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.96 ADH1B ADH7
6 glutamate-gated calcium ion channel activity GO:0022849 8.62 GRIN2A GRIN2B

Sources for Fetal Alcohol Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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