MCID: FTL001
MIFTS: 59

Fetal Alcohol Syndrome

Categories: Fetal diseases, Rare diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Fetal Alcohol Syndrome

MalaCards integrated aliases for Fetal Alcohol Syndrome:

Name: Fetal Alcohol Syndrome 12 76 59 55 15 73
Fetal Alcohol Spectrum Disorders 59 73
Fetus or Newborn Affected by Alcohol Transmitted Via Placenta or Breast Milk 73
Alcohol-Related Neurodevelopmental Disorder 59
Alcohol Related Neurodevelopmental Disorder 73
Alcohol-Related Birth Defects 59
Alcohol Related Birth Defect 73
Arnd 59
Arbd 59
Fasd 59
Fas 59

Characteristics:

Orphanet epidemiological data:

59
fetal alcohol syndrome
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Austria),1-9/100000 (Belgium),1-5/10000 (Germany),1-9/100000 (Hungary),1-9/100000 (Ireland),1-9/100000 (Italy),1-9/100000 (Norway),1-5/10000 (Switzerland),1-9/100000 (United Kingdom),1-5/10000 (France),1-9/1000000 (Poland),1-9/100000 (Spain),6-9/10000 (Ukraine); Age of onset: Antenatal,Neonatal; Age of death: any age;

Classifications:



Summaries for Fetal Alcohol Syndrome

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

MalaCards based summary : Fetal Alcohol Syndrome, also known as fetal alcohol spectrum disorders, is related to fetal alcohol spectrum disorder and partial fetal alcohol syndrome. An important gene associated with Fetal Alcohol Syndrome is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Glucose metabolism and Dopamine-DARPP32 Feedback onto cAMP Pathway. The drugs Ethanol and Epigallocatechin gallate have been mentioned in the context of this disorder. Affiliated tissues include eye, placenta and breast, and related phenotypes are cleft palate and thin upper lip vermilion

Wikipedia : 76 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose... more...

Related Diseases for Fetal Alcohol Syndrome

Diseases in the Fetal Alcohol Syndrome family:

Fetal Alcohol Spectrum Disorder

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol spectrum disorder 29.0 ADH7 GRIN2A GRIN2B MIR496 PFAS RBP1
2 partial fetal alcohol syndrome 12.4
3 autoimmune lymphoproliferative syndrome 12.2
4 fanconi anemia, complementation group a 12.0
5 alcohol-related birth defect 11.8
6 friedreich ataxia 1 11.5
7 lung cancer 11.5
8 dianzani autoimmune lymphoproliferative disease 11.5
9 lymphoproliferative syndrome 11.5
10 colorectal cancer 11.4
11 squamous cell carcinoma 11.3
12 methanol poisoning 10.7 ADH1B AKR1A1
13 subcortical arteriosclerotic encephalopathy 10.6 GFAP VIP
14 binswanger's disease 10.5 GFAP VIP
15 alcoholic pancreatitis 10.4 ADH1B ALDH2
16 cornea cancer 10.2 GFAP GRIN2A
17 von economo's disease 10.2 GFAP GRIN2B
18 aging 10.0
19 neuronitis 10.0
20 epilepsy, focal, with speech disorder and with or without mental retardation 10.0 GRIN2A GRIN2B
21 alcohol-related neurodevelopmental disorder 9.9
22 ganglioneuroma 9.9 GFAP VIP
23 status epilepticus 9.9 GFAP GRIN2B PVALB
24 ocular dominance 9.9 GRIN2A GRIN2B
25 optic nerve hypoplasia, bilateral 9.9
26 d-2-hydroxyglutaric aciduria 1 9.8 GRIN2A GRIN2B
27 gilles de la tourette syndrome 9.8
28 attention deficit-hyperactivity disorder 9.8
29 autism 9.8
30 substance abuse 9.8
31 hersh podruch weisskopk syndrome 9.8
32 valproate embryopathy 9.7 GRIN2A GRIN2B
33 toxic encephalopathy 9.7 GFAP GRIN2A GRIN2B
34 cleft palate, isolated 9.6
35 prader-willi syndrome 9.6
36 schizophrenia 9.6
37 neural tube defects 9.6
38 digeorge syndrome 9.6
39 down syndrome 9.6
40 chiari malformation type ii 9.6
41 phenylketonuria 9.6
42 schizencephaly 9.6
43 sudden infant death syndrome 9.6
44 spondylocarpotarsal synostosis syndrome 9.6
45 cognitive function 1, social 9.6
46 fragile x syndrome 9.6
47 rett syndrome 9.6
48 neural tube defects, folate-sensitive 9.6
49 body mass index quantitative trait locus 1 9.6
50 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 9.6

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to Fetal Alcohol Syndrome

Symptoms & Phenotypes for Fetal Alcohol Syndrome

Human phenotypes related to Fetal Alcohol Syndrome:

59 32 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cleft palate 59 32 occasional (7.5%) Occasional (29-5%) HP:0000175
2 thin upper lip vermilion 59 32 frequent (33%) Frequent (79-30%) HP:0000219
3 microcephaly 59 32 hallmark (90%) Very frequent (99-80%) HP:0000252
4 narrow face 59 32 hallmark (90%) Very frequent (99-80%) HP:0000275
5 epicanthus 59 32 frequent (33%) Frequent (79-30%) HP:0000286
6 smooth philtrum 59 32 frequent (33%) Frequent (79-30%) HP:0000319
7 micrognathia 59 32 frequent (33%) Frequent (79-30%) HP:0000347
8 low-set, posteriorly rotated ears 59 32 frequent (33%) Frequent (79-30%) HP:0000368
9 anteverted nares 59 32 frequent (33%) Frequent (79-30%) HP:0000463
10 strabismus 59 32 frequent (33%) Frequent (79-30%) HP:0000486
11 telecanthus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000506
12 ptosis 59 32 frequent (33%) Frequent (79-30%) HP:0000508
13 microphthalmia 59 32 frequent (33%) Frequent (79-30%) HP:0000568
14 microdontia 59 32 frequent (33%) Frequent (79-30%) HP:0000691
15 behavioral abnormality 59 32 hallmark (90%) Very frequent (99-80%) HP:0000708
16 congenital diaphragmatic hernia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000776
17 intellectual disability 59 32 hallmark (90%) Very frequent (99-80%) HP:0001249
18 global developmental delay 59 32 hallmark (90%) Very frequent (99-80%) HP:0001263
19 specific learning disability 59 32 hallmark (90%) Very frequent (99-80%) HP:0001328
20 joint stiffness 59 32 frequent (33%) Frequent (79-30%) HP:0001387
21 intrauterine growth retardation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001511
22 atrial septal defect 59 32 frequent (33%) Frequent (79-30%) HP:0001631
23 generalized hirsutism 59 32 occasional (7.5%) Occasional (29-5%) HP:0002230
24 short nose 59 32 frequent (33%) Frequent (79-30%) HP:0003196
25 vertebral segmentation defect 59 32 frequent (33%) Frequent (79-30%) HP:0003422
26 short stature 59 32 hallmark (90%) Very frequent (99-80%) HP:0004322
27 biparietal narrowing 59 32 frequent (33%) Frequent (79-30%) HP:0004422
28 abnormal dermatoglyphics 59 32 frequent (33%) Frequent (79-30%) HP:0007477
29 abnormality of immune system physiology 59 32 frequent (33%) Frequent (79-30%) HP:0010978
30 non-midline cleft lip 59 32 frequent (33%) Frequent (79-30%) HP:0100335
31 cognitive impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0100543
32 visceral angiomatosis 59 32 frequent (33%) Frequent (79-30%) HP:0100761

MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 ADH7 ALDH2 CHRM3 GFAP GRIN2A GRIN2B
2 growth/size/body region MP:0005378 9.81 ADH7 AKR1A1 ALDH2 CHRM3 GFAP GRIN2B
3 homeostasis/metabolism MP:0005376 9.61 ADH7 AKR1A1 ALDH2 CHRM3 GFAP GRIN2B
4 nervous system MP:0003631 9.23 CHRM3 GFAP GRIN2A GRIN2B PVALB RBP1

Drugs & Therapeutics for Fetal Alcohol Syndrome

Drugs for Fetal Alcohol Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
2
Epigallocatechin gallate Investigational Phase 2, Phase 3 989-51-5 65064
3 Anti-Infective Agents Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
4 Anti-Infective Agents, Local Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
5 Antioxidants Phase 2, Phase 3
6 Central Nervous System Depressants Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
7 Neuroprotective Agents Phase 2, Phase 3
8 Protective Agents Phase 2, Phase 3
9 Adrenergic Agents Phase 3,Phase 1
10 Atomoxetine Hydrochloride Phase 3,Phase 1
11 Neurotransmitter Agents Phase 3,Phase 1
12 Neurotransmitter Uptake Inhibitors Phase 3,Phase 1
13
Epigallocatechin Experimental, Investigational, Nutraceutical Phase 2, Phase 3 970-74-1 72277
14
Choline Approved, Nutraceutical Phase 2,Phase 1 62-49-7 305
15 Antimetabolites Phase 2,Phase 1
16 Gastrointestinal Agents Phase 2,Phase 1
17 Hypolipidemic Agents Phase 2,Phase 1
18 Lipid Regulating Agents Phase 2,Phase 1
19 Nootropic Agents Phase 2,Phase 1
20
Nicotine Approved Not Applicable 54-11-5 942 89594
21
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
22 tannic acid Approved, Nutraceutical Not Applicable

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Epigallocatechin Gallate (EGCG) to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children Unknown status NCT02558933 Phase 2, Phase 3
2 Open-Label Study of the Long Term Tolerability and Safety of Atomoxetine in Children With FASD and ADD/ADHD Completed NCT00418262 Phase 3 Atomoxetine
3 Fetal Alcohol Syndrome/ARND Research Consortion Completed NCT00164554 Phase 1, Phase 2
4 Fetal Alcohol Syndrome: Socio-Cognitive Habilitation Completed NCT00164229 Phase 1, Phase 2
5 Neurocognitive Habilitation for Children With Fetal Alcohol Syndrome (FAS)/Alcohol-Related Neurodevelopmental Disorder (ARND) Completed NCT00164346 Phase 1, Phase 2
6 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
7 A Media Based Motivational Intervention to Prevent Alcohol Exposed Pregnancies (AEPs) Completed NCT00219336 Phase 2
8 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2 Choline bitartrate
9 Project CHOICES Efficacy Study Completed NCT00153478 Phase 2
10 Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Recruiting NCT02735473 Phase 2 Choline bitartrate;Placebo
11 Neighborhood Alcohol & HIV Prevention in South African Townships (Philani) Active, not recruiting NCT00996528 Phase 2
12 Assess the Effectiveness of Atomoxetine in Children With Fetal Alcohol Syndrome and ADD/ADHD Completed NCT00417794 Phase 1 Strattera;Placebo
13 Parenting Training for Children With FASD Unknown status NCT02210455 Not Applicable
14 Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention Completed NCT02457676 Not Applicable
15 Development of Education Materials for Prevention of FAS in Russia Completed NCT01971398 Not Applicable
16 Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With FASD Completed NCT01536184 Not Applicable
17 Contraception and Alcohol Risk Reduction Internet Intervention Randomized Trial Completed NCT02128880 Not Applicable
18 Preventing FAS/ARND in Russian Children Completed NCT01961050 Not Applicable
19 Fetal Alcohol Damage Prevention Study Completed NCT00696085 Not Applicable
20 Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603 Not Applicable
21 Healthy Moms Alcohol Intervention Completed NCT00244062 Not Applicable
22 Effects of Hyperbaric Oxygen Therapy in Autistic Children: A Pilot Study Completed NCT00324909 Not Applicable Hyperbaric Oxygen Therapy
23 Comprehensive Program for Youth Mental Health Completed NCT02169960 Not Applicable
24 Modeling and Testing Change in Mental Abilities in Childhood Completed NCT02459873 Not Applicable
25 Reducing Alcohol Exposed Pregnancy Risk: EARLY Randomized Controlled Trial Completed NCT01446653 Not Applicable
26 Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum Disorder Recruiting NCT03494738
27 Cognitive Training and tDCS for Children With FASD Recruiting NCT03361293 Not Applicable
28 In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions Recruiting NCT03371641 Not Applicable
29 Prenatal Alcohol Biomarker Study in Uruguay Recruiting NCT02600624
30 Self-Regulation in Adolescents With FASD: The Efficacy of a Targeted Intervention Recruiting NCT02912962 Not Applicable
31 Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial Recruiting NCT03342495 Not Applicable
32 Prevention of Fetal Alcohol Spectrum Disorder (FASD) by the Use of Technology Enrolling by invitation NCT02759874 Not Applicable
33 A Study of Parent and Child Emotions in Fetal Alcohol Spectrum Disorder (FASD) Not yet recruiting NCT03524664 Not Applicable
34 Better Nights, Better Days for Children With Neurodevelopment Disorders Not yet recruiting NCT02694003 Not Applicable
35 Evaluating the Efficacy of a Video Based Intervention to Educate Teen Moms About Fetal Alcohol Syndrome (FAS) Terminated NCT00747630 Early Phase 1

Search NIH Clinical Center for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

Anatomical Context for Fetal Alcohol Syndrome

MalaCards organs/tissues related to Fetal Alcohol Syndrome:

41
Eye, Placenta, Breast, Brain, Testes, Fetal Brain, Liver

Publications for Fetal Alcohol Syndrome

Articles related to Fetal Alcohol Syndrome:

(show top 50) (show all 557)
# Title Authors Year
1
Recognition of clinical characteristics for population-based surveillance of fetal alcohol syndrome. ( 29368410 )
2018
2
<i>Xenopus</i> embryos to study Fetal Alcohol Syndrome, a model for environmental teratogenesis. ( 29069552 )
2017
3
Fetal Alcohol Syndrome and Fetal Alcohol Spectrum Disorders. ( 29094891 )
2017
4
Differences in neural crest sensitivity to ethanol account for the infrequency of anterior segment defects in the eye compared with craniofacial anomalies in a zebrafish model of fetal alcohol syndrome. ( 28681995 )
2017
5
Unreliable estimation of prevalence of fetal alcohol syndrome. ( 28495259 )
2017
6
Unreliable estimation of prevalence of fetal alcohol syndrome. ( 28495260 )
2017
7
Unreliable estimation of prevalence of fetal alcohol syndrome - Authors' reply. ( 28495261 )
2017
8
Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis. ( 28089487 )
2017
9
Competition between ethanol clearance and retinoic acid biosynthesis in the induction of Fetal Alcohol Syndrome. ( 28982012 )
2017
10
Digital assessment of the fetal alcohol syndrome facial phenotype: reliability and agreement study. ( 29637153 )
2017
11
The Prevalence of Fetal Alcohol Syndrome and Its Impact on a Child's Classroom Performance: A Case Study of a Rural South African School. ( 28792446 )
2017
12
Fetal Alcohol Syndrome Disorder: diminished responsibility and mitigation of sentence. ( 28699765 )
2017
13
A Rat Model of Fetal Alcohol Syndrome: A Series of Undergraduate Laboratory Exercises for Biopsychology Courses. ( 28690436 )
2017
14
Fetal Alcohol Syndrome ( 28846263 )
2017
15
High global prevalence of alcohol use during pregnancy and fetal alcohol syndrome indicates need for urgent action. ( 28089488 )
2017
16
Genetic predisposition to fetal alcohol syndrome: association with congenital disorders of N-glycosylation. ( 28820871 )
2017
17
Societal costs of fetal alcohol syndrome in Sweden. ( 27279344 )
2016
18
An Update on Fetal Alcohol Syndrome-Pathogenesis, Risks, and Treatment. ( 27375266 )
2016
19
Magnetic resonance imaging (MRI) findings among children with fetal alcohol syndrome (FAS), partial fetal alcohol syndrome (pFAS) and alcohol related neurodevelopmental disorders (ARND). ( 29688653 )
2016
20
Life Expectancy of People with Fetal Alcohol Syndrome. ( 26962962 )
2016
21
Changes in drinking patterns during and after pregnancy among mothers of children with fetal alcohol syndrome: A study in three districts of South Africa. ( 27610936 )
2016
22
Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis. ( 27349777 )
2016
23
Modeling Symptoms of Attention-Deficit Hyperactivity Disorder in a Rat Model of Fetal Alcohol Syndrome. ( 27117236 )
2016
24
Fetal Alcohol Syndrome and Maternal Alcohol Biomarkers in Sera: A Register-Based Case-Control Study. ( 27228551 )
2016
25
Fetal Alcohol Syndrome in Sudden Unexpected Death in Infancy: A Case Report in Medicolegal Autopsy. ( 26730801 )
2016
26
Childhood placement in out-of-home care in relation to psychosocial outcomes in adults with fetal alcohol syndrome. ( 27371665 )
2016
27
Mental and Motor Development of Children with Preterm Birth and Children with Fetal Alcohol Syndrome. ( 26038965 )
2015
28
Reduced DNA methylation at the PEG3 DMR and KvDMR1 loci in children exposed to alcohol in utero: a South African Fetal Alcohol Syndrome cohort study. ( 25806045 )
2015
29
Fetal alcohol syndrome among children aged 7-9 years - Arizona, Colorado, and New York, 2010. ( 25632951 )
2015
30
Psychosocial outcomes of fetal alcohol syndrome in adulthood. ( 25535260 )
2015
31
Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. ( 26421061 )
2015
32
Methods for surveillance of fetal alcohol syndrome: The fetal alcohol syndrome surveillance network II (FASSNetII) - Arizona, Colorado, New York, 2009 - 2014. ( 25761572 )
2015
33
Cognitive and executive functions, social cognition and sense of coherence in adults with fetal alcohol syndrome. ( 25697067 )
2015
34
A transition in fetal alcohol syndrome research: the shift from animal modeling to human intervention. ( 25614482 )
2015
35
Prevalence and characteristics of fetal alcohol syndrome and partial fetal alcohol syndrome in a Rocky Mountain Region City. ( 26321671 )
2015
36
Prevalence of fetal alcohol syndrome in a South African city with a predominantly Black African population. ( 25941030 )
2015
37
Prevalence of fetal alcohol syndrome in a population-based sample of children living in remote Australia: The Lililwan Project. ( 25594247 )
2015
38
Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. ( 25667671 )
2015
39
Ethanol-induced impairment of polyamine homeostasis--a potential cause of neural tube defect and intrauterine growth restriction in fetal alcohol syndrome. ( 24582559 )
2014
40
Habilitational treatment of a child with fetal alcohol syndrome: case report. ( 24974670 )
2014
41
Renal dysfunction in fetal alcohol syndrome: a potential contributor on developmental disabilities of offspring. ( 25610884 )
2014
42
Neural crest development in fetal alcohol syndrome. ( 25219761 )
2014
43
Fetal alcohol syndrome, chemo-biology and OMICS: ethanol effects on vitamin metabolism during neurodevelopment as measured by systems biology analysis. ( 24816220 )
2014
44
Brainstem Disconnection in a Late Preterm Neonate With Classic Features of Fetal Alcohol Syndrome. ( 25152965 )
2014
45
Fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorder (FASD)-diagnosis and moral policing; an ethical dilemma for paediatricians. ( 25005521 )
2014
46
Fetal alcohol syndrome surveillance: age of syndrome manifestation in case ascertainment. ( 24737611 )
2014
47
Exploring the feasibility of using electronic health records in the surveillance of fetal alcohol syndrome. ( 24591358 )
2014
48
Brainstem disconnection in a patient with fetal alcohol syndrome. ( 25079579 )
2014
49
Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome. ( 25027850 )
2014
50
Fetal Alcohol Syndrome In Ghana:Case Series Report From Korle Bu Teaching Hospital, Accra. ( 26445073 )
2014

Variations for Fetal Alcohol Syndrome

Expression for Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for Fetal Alcohol Syndrome

Pathways related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.25 ADH1B ADH7 AKR1A1 ALDH2
2 12.04 GRIN2A GRIN2B KCNJ2
3 11.99 GFAP GRIN2A GRIN2B VIP
4
Show member pathways
11.85 ADH1B AKR1A1 ALDH2
5 11.1 GRIN2A GRIN2B
6
Show member pathways
11.1 ADH1B ADH7 ALDH2
7 10.94 GRIN2A GRIN2B
8 10.92 GRIN2A GRIN2B
9 10.73 GRIN2A GRIN2B
10
Show member pathways
10.5 ADH1B ALDH2
11
Show member pathways
10.43 ADH1B ALDH2
12
Show member pathways
10.42 ADH1B ADH7 AKR1A1 ALDH2

GO Terms for Fetal Alcohol Syndrome

Cellular components related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic density membrane GO:0098839 9.16 GRIN2A GRIN2B
2 synaptic membrane GO:0097060 8.96 GRIN2A GRIN2B
3 NMDA selective glutamate receptor complex GO:0017146 8.62 GRIN2A GRIN2B

Biological processes related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.58 ADH7 GRIN2A GRIN2B
2 retinol metabolic process GO:0042572 9.48 ADH7 RBP1
3 ionotropic glutamate receptor signaling pathway GO:0035235 9.46 GRIN2A GRIN2B
4 retinoic acid metabolic process GO:0042573 9.43 ADH7 RBP1
5 glutamate receptor signaling pathway GO:0007215 9.37 GRIN2A GRIN2B
6 ethanol catabolic process GO:0006068 9.32 ADH7 ALDH2
7 excitatory chemical synaptic transmission GO:0098976 9.26 GRIN2A GRIN2B
8 calcium ion transmembrane import into cytosol GO:0097553 9.16 GRIN2A GRIN2B
9 long-term synaptic potentiation GO:0060291 9.13 GFAP GRIN2A GRIN2B
10 ethanol oxidation GO:0006069 8.8 ADH1B ADH7 ALDH2

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ionotropic glutamate receptor activity GO:0004970 9.37 GRIN2A GRIN2B
2 extracellularly glutamate-gated ion channel activity GO:0005234 9.32 GRIN2A GRIN2B
3 retinol binding GO:0019841 9.26 ADH7 RBP1
4 NMDA glutamate receptor activity GO:0004972 9.16 GRIN2A GRIN2B
5 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.96 ADH1B ADH7
6 glutamate-gated calcium ion channel activity GO:0022849 8.62 GRIN2A GRIN2B

Sources for Fetal Alcohol Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....