FAS
MCID: FTL001
MIFTS: 55

Fetal Alcohol Syndrome (FAS)

Categories: Fetal diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Fetal Alcohol Syndrome

MalaCards integrated aliases for Fetal Alcohol Syndrome:

Name: Fetal Alcohol Syndrome 12 74 58 54 15 71 32
Fetal Alcohol Spectrum Disorders 58 71
Fetus or Newborn Affected by Alcohol Transmitted Via Placenta or Breast Milk 71
Alcohol-Related Neurodevelopmental Disorder 58
Alcohol Related Neurodevelopmental Disorder 71
Alcohol-Related Birth Defects 58
Alcohol Related Birth Defect 71
Arnd 58
Arbd 58
Fasd 58
Fas 58

Characteristics:

Orphanet epidemiological data:

58
fetal alcohol syndrome
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Austria),1-9/100000 (Belgium),1-5/10000 (Germany),1-9/100000 (Hungary),1-9/100000 (Ireland),1-9/100000 (Italy),1-9/100000 (Norway),1-5/10000 (Switzerland),1-9/100000 (United Kingdom),1-5/10000 (France),1-9/1000000 (Poland),1-9/100000 (Spain),6-9/10000 (Ukraine); Age of onset: Antenatal,Neonatal; Age of death: any age;

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis
Teratologic disorders


External Ids:

Disease Ontology 12 DOID:0050665
ICD10 32 Q86.0
MESH via Orphanet 45 D005310
ICD10 via Orphanet 33 Q86.0
UMLS via Orphanet 72 C0015923 C0814154 C2985290 more
Orphanet 58 ORPHA1915
UMLS 71 C0015923 C0814154 C1542327 more

Summaries for Fetal Alcohol Syndrome

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

MalaCards based summary : Fetal Alcohol Syndrome, also known as fetal alcohol spectrum disorders, is related to alcohol-related birth defect and alcohol use disorder. An important gene associated with Fetal Alcohol Syndrome is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. The drugs Ethanol and Choline have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related phenotypes are intellectual disability and global developmental delay

Wikipedia : 74 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose... more...

Related Diseases for Fetal Alcohol Syndrome

Diseases in the Fetal Alcohol Syndrome family:

Fetal Alcohol Spectrum Disorder

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1190)
# Related Disease Score Top Affiliating Genes
1 alcohol-related birth defect 32.8 CYP2E1 ADH1B
2 alcohol use disorder 31.5 H2AC18 GRIN2B CYP2E1 BDNF ALDH2 AKR1A1
3 fetal alcohol spectrum disorder 31.1 PVALB MIR9-1 L1CAM KDM4C H2AC18 GRIN2B
4 traumatic brain injury 30.6 GFAP BDNF
5 substance abuse 30.4 H2AC18 CYP2E1 BDNF ALDH2 ADH1B
6 status epilepticus 30.3 PVALB GRIN2B GFAP CALB2 BDNF
7 mental depression 30.2 H2AC18 GRIN2B BDNF
8 malignant astrocytoma 30.2 MIR9-1 KDM4C H2AC18 GFAP
9 alcohol dependence 30.2 GRIN2B CYP2E1 BDNF ALDH2 AKR1A1 ADH7
10 drug dependence 30.1 BDNF ADH7 ADH1B
11 speech disorder 30.1 PVALB H2AC18 GRIN2B
12 autism spectrum disorder 30.1 MIR9-1 H2AC18 GRIN2B GFAP BDNF ADNP
13 psychotic disorder 30.0 PVALB MIR9-1 H2AC18 GRIN2B BDNF
14 amyotrophic lateral sclerosis 1 29.9 PVALB MIR9-1 H2AC18 GFAP CALB2 BDNF
15 fragile x syndrome 29.8 PVALB MIR9-1 H2AC18 GRIN2B BDNF
16 peripheral nervous system disease 29.8 MIR9-1 KDM4C H2AC18 GFAP BDNF
17 scrapie 29.8 PVALB MIR9-1 GFAP
18 supranuclear palsy, progressive, 1 29.7 PVALB GFAP ADNP
19 rett syndrome 29.7 VIP L1CAM H2AC18 BDNF
20 alcoholic liver cirrhosis 29.7 CYP2E1 ALDH2 AKR1A1 ADH1B
21 pervasive developmental disorder 29.6 PVALB MIR9-1 KDM4C H2AC18 GRIN2B BDNF
22 autism 29.6 KDM4C KCNJ2 GRIN2B GFAP CALB2 BDNF
23 parkinson disease, late-onset 29.5 PVALB MIR9-1 H2AC18 GRIN2B CALB2 BDNF
24 migraine with or without aura 1 29.4 VIP H2AC18 GRIN2B BDNF
25 nervous system disease 29.4 MIR9-1 KDM4C H2AC18 GFAP BDNF
26 schizophrenia 29.1 PVALB MIR9-1 GRIN2B GFAP CALB2 BDNF
27 disease of mental health 28.0 VIP PVALB MIR9-1 L1CAM KDM4C H2AC18
28 partial fetal alcohol syndrome 11.6
29 autoimmune lymphoproliferative syndrome 11.6
30 graft-versus-host disease 11.4
31 lung cancer 11.3
32 lymphoproliferative syndrome 11.2
33 adult t-cell leukemia 11.2
34 colorectal cancer 11.2
35 impulse control disorder 11.2
36 dianzani autoimmune lymphoproliferative disease 11.2
37 mycosis fungoides 11.2
38 ovarian cancer 11.2
39 autoimmune disease 11.2
40 systemic lupus erythematosus 11.1
41 hepatitis c 11.1
42 gastric cancer 11.1
43 lymphoma 11.1
44 squamous cell carcinoma 11.1
45 breast cancer 11.1
46 caspase 8 deficiency 11.1
47 prostate cancer 11.1
48 pancreatic cancer 11.1
49 lymphoma, non-hodgkin, familial 11.1
50 b-cell lymphoma 11.1

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to Fetal Alcohol Syndrome

Symptoms & Phenotypes for Fetal Alcohol Syndrome

Human phenotypes related to Fetal Alcohol Syndrome:

58 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intellectual disability 58 31 hallmark (90%) Very frequent (99-80%) HP:0001249
2 global developmental delay 58 31 hallmark (90%) Very frequent (99-80%) HP:0001263
3 behavioral abnormality 58 31 hallmark (90%) Very frequent (99-80%) HP:0000708
4 microcephaly 58 31 hallmark (90%) Very frequent (99-80%) HP:0000252
5 short stature 58 31 hallmark (90%) Very frequent (99-80%) HP:0004322
6 cognitive impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0100543
7 intrauterine growth retardation 58 31 hallmark (90%) Very frequent (99-80%) HP:0001511
8 specific learning disability 58 31 hallmark (90%) Very frequent (99-80%) HP:0001328
9 narrow face 58 31 hallmark (90%) Very frequent (99-80%) HP:0000275
10 telecanthus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000506
11 ptosis 58 31 frequent (33%) Frequent (79-30%) HP:0000508
12 joint stiffness 58 31 frequent (33%) Frequent (79-30%) HP:0001387
13 short nose 58 31 frequent (33%) Frequent (79-30%) HP:0003196
14 smooth philtrum 58 31 frequent (33%) Frequent (79-30%) HP:0000319
15 anteverted nares 58 31 frequent (33%) Frequent (79-30%) HP:0000463
16 strabismus 58 31 frequent (33%) Frequent (79-30%) HP:0000486
17 microdontia 58 31 frequent (33%) Frequent (79-30%) HP:0000691
18 biparietal narrowing 58 31 frequent (33%) Frequent (79-30%) HP:0004422
19 micrognathia 58 31 frequent (33%) Frequent (79-30%) HP:0000347
20 abnormal dermatoglyphics 58 31 frequent (33%) Frequent (79-30%) HP:0007477
21 epicanthus 58 31 frequent (33%) Frequent (79-30%) HP:0000286
22 atrial septal defect 58 31 frequent (33%) Frequent (79-30%) HP:0001631
23 abnormality of immune system physiology 58 31 frequent (33%) Frequent (79-30%) HP:0010978
24 low-set, posteriorly rotated ears 58 31 frequent (33%) Frequent (79-30%) HP:0000368
25 microphthalmia 58 31 frequent (33%) Frequent (79-30%) HP:0000568
26 thin upper lip vermilion 58 31 frequent (33%) Frequent (79-30%) HP:0000219
27 vertebral segmentation defect 58 31 frequent (33%) Frequent (79-30%) HP:0003422
28 visceral angiomatosis 58 31 frequent (33%) Frequent (79-30%) HP:0100761
29 non-midline cleft lip 58 31 frequent (33%) Frequent (79-30%) HP:0100335
30 cleft palate 58 31 occasional (7.5%) Occasional (29-5%) HP:0000175
31 generalized hirsutism 58 31 occasional (7.5%) Occasional (29-5%) HP:0002230
32 congenital diaphragmatic hernia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000776

MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 ADH7 ALDH2 BDNF CALB2 CHRM3 CYP2E1
2 mortality/aging MP:0010768 9.44 ADH7 ADNP AKR1A1 ALDH2 BDNF CYP2E1

Drugs & Therapeutics for Fetal Alcohol Syndrome

Drugs for Fetal Alcohol Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2, Phase 3 64-17-5 702
2
Choline Approved, Nutraceutical Phase 2, Phase 3 62-49-7 305
3 Neurotransmitter Agents Phase 3
4 Atomoxetine Hydrochloride Phase 3
5 Adrenergic Agents Phase 3
6 Gastrointestinal Agents Phase 2, Phase 3
7 Hypolipidemic Agents Phase 2, Phase 3
8 Antimetabolites Phase 2, Phase 3
9 Lipid Regulating Agents Phase 2, Phase 3
10
Glycerol Approved, Investigational Phase 2 56-81-5 753
11 Protective Agents Phase 2
12
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
13
tannic acid Approved 1401-55-4
14
Nicotine Approved 54-11-5 942 89594
15
Nitric Oxide Approved 10102-43-9 145068
16
Fluoxymesterone Approved, Illicit 76-43-7 6446
17
Epigallocatechin Experimental, Investigational 970-74-1 72277
18
Epigallocatechin gallate Investigational 989-51-5 65064
19
Imidacloprid Vet_approved 105827-78-9 86418
20 Antioxidants
21 Neuroprotective Agents
22 Vitamins

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 An Open-label Study of the Long Term Tolerability and Safety of Atomoxetine in Treating the Inattention, Impulsivity and Hyperactivity in Children With Fetal-Alcohol Syndrome or Effects. Completed NCT00418262 Phase 3 Atomoxetine
2 A Randomized, Double-Blind, Placebo-controlled Clinical Trial of Choline Supplementation During Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Development Not yet recruiting NCT04395196 Phase 2, Phase 3
3 Neurocognitive Habilitation for Children With FAS/ARND Completed NCT00164346 Phase 1, Phase 2
4 Fetal Alcohol Syndrome/ARND Research Consortion-Oklahoma Completed NCT00164554 Phase 1, Phase 2
5 Study to Investigate the Effectiveness of a Math Intervention for Children With Fetal Alcohol Syndrome or Related Condition Completed NCT00164229 Phase 1, Phase 2
6 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
7 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2 Choline bitartrate
8 A Media Based Motivational Intervention to Reduce Alcohol Exposed Pregnancies (AEPs) Completed NCT00219336 Phase 2
9 Intervening With Children/Adolescents With FAS/ARND Completed NCT00164528 Phase 1, Phase 2
10 Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Recruiting NCT02735473 Phase 2 Choline bitartrate;Placebo
11 Neighborhood Alcohol & HIV Prevention in South African Townships (Philani) Active, not recruiting NCT00996528 Phase 2
12 A Study of the Efficacy of Atomoxetine in Treating the Inattention, Impulsivity and Hyperactivity in Children With Fetal Alcohol Syndrome or Effects Completed NCT00417794 Phase 1 Strattera;Placebo
13 Prevention of Fetal Alcohol Spectrum Disorder (FASD) by the Use of Technology Unknown status NCT02759874
14 Effectiveness of Visual and Auditory Feedback on Eye-hand Coordination in Children With Hemiplegic Cerebral Palsy Unknown status NCT03742999
15 Development of Education Materials for Prevention of Fetal Alcohol Syndrome (FAS) in Russia Completed NCT01971398
16 Preventing FAS/ARND in Russian Children Completed NCT01961050
17 Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention Completed NCT02457676
18 Prevention of Fetal Alcohol Damage Using Maternal Blood Markers Completed NCT00696085
19 Epigallocatechin Gallate (EGCG) as Therapeutic Tool to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children Completed NCT02558933
20 "Brief Alcohol Intervention: The Healthy Moms Project." Completed NCT00244062
21 Newborn Phosphatidylethanol Screening to Detect Fetal Alcohol Exposure in Uruguay Completed NCT02600624
22 Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With Fetal Alcohol Spectrum Disorder (FASD) or At-risk for FASD: A Randomized Controlled Field Trial Completed NCT01536184
23 Strongest Families FASD: Parent Training for Challenging Behaviour in Children With Fetal Alcohol Spectrum Disorder (FASD) Completed NCT02210455
24 Early Identification of Affected Children and Nutritional Risk Factors for FASD in Ukraine Completed NCT03782935
25 Neuromodulation Augmented Cognitive Remediation to Improve Executive Dysfunction in Fetal Alcohol Spectrum Disorder (FASD) Completed NCT03361293
26 Dog-Assisted Therapy for Children and Adolescents With FASD: a Randomized Controlled Pilot Study Completed NCT04038164
27 Preventing FAS/ARND in Russian Children/Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603
28 Self-Regulation in Adolescents With FASD: The Efficacy of a Targeted Intervention Completed NCT02912962
29 A Randomized Clinical Trial of the Contraception and Alcohol Risk Reduction Internet Intervention to Reduce AEP Risk in Community Women Completed NCT02128880
30 Fetal Alcohol Spectrum Disorder-Is This a Ciliopathy? Completed NCT03802708
31 Augmented Biofeedback Training Combined With Physical Therapy Program Improves Visual-motor Integration, Visual Perception and Motor Coordination in Children With Spastic Hemiplegic Cerebral Palsy: a Randomized Control Trial Completed NCT03626077
32 In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions Recruiting NCT03371641
33 Parent Emotion Socialization and Child Emotion Regulation in FASD Recruiting NCT03524664
34 Feasibility Trial of the FMF Connect Mobile Health Intervention Recruiting NCT04194489
35 The Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Life Span: Continuing Prevention and Longitudinal Epidemiology Recruiting NCT04026620
36 Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum Disorder Recruiting NCT03494738
37 Etyyliglukuronidin Esiintyminen Virtsassa äitiysneuvola- ja äitiyspoliklinikkakäyntien yhteydessä HUS:n ja PHHYKY:n Alueella Recruiting NCT04571463
38 Dissecting the Genetics of Fetal Alcohol Spectrum Disorders Recruiting NCT04072809
39 CHILD-BRIGHT READYorNot[TM] Brain-Based Disabilities Trial Recruiting NCT03852550
40 Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial Recruiting NCT03342495
41 Hyperbaric Oxygen Therapy vs. Cognitive Training for Fetal Alcohol Spectrum Disorder; A Prospective, Randomized Clinical Trial Not yet recruiting NCT04664790
42 Scaling Up: A Multi-Site Trial of e-SBI for Alcohol Use in Pregnancy Not yet recruiting NCT04332172
43 Evaluating the Efficacy of a Video Based Intervention to Educate Teen Moms About Fetal Alcohol Syndrome Terminated NCT00747630 Early Phase 1

Search NIH Clinical Center for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

Anatomical Context for Fetal Alcohol Syndrome

MalaCards organs/tissues related to Fetal Alcohol Syndrome:

40
Brain, Eye, Cortex, Placenta, Breast, Cerebellum, Heart

Publications for Fetal Alcohol Syndrome

Articles related to Fetal Alcohol Syndrome:

(show top 50) (show all 3113)
# Title Authors PMID Year
1
Effect of gestational ethanol exposure on parvalbumin and calretinin expressing hippocampal neurons in a chick model of fetal alcohol syndrome. 61 54
19251116 2009
2
Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview. 54 61
17618743 2007
3
The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome. 61 54
7748347 1993
4
A hypothetical mechanism for fetal alcohol syndrome involving ethanol inhibition of retinoic acid synthesis at the alcohol dehydrogenase step. 54 61
1877746 1991
5
Use of Telemedicine for the Physical Examination of Children With Fetal Alcohol Spectrum Disorders. 61
33316074 2021
6
Prevalence of Fetal Alcohol Spectrum Disorders (FASD) among Children Adopted from Eastern European Countries: Russia and Ukraine. 61
33546212 2021
7
Infant Cardiac Orienting Responses Predict Later FASD in the Preschool Period. 61
33277942 2021
8
Disability, Hospital Care, and Cost: Utilization of Emergency and Inpatient Care by a Cohort of Children with Intellectual and Developmental Disabilities. 61
32890584 2021
9
Early-life exposure to alcohol and the risk of alcohol-induced liver disease in adulthood. 61
33577143 2021
10
Executive and Social Functioning Across Development in Children and Adolescents With Prenatal Alcohol Exposure. 61
33349933 2021
11
Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure. 61
33606320 2021
12
Estimated Prevalence of Harmful Alcohol Consumption in Pregnant and Non-pregnant Women in Saxony-Anhalt (North-East Germany) Using Biomarkers. 61
33547677 2021
13
Examination of cortically projecting cholinergic neurons following exercise and environmental intervention in a rodent model of fetal alcohol spectrum disorders. 61
33174398 2021
14
Evolution of the Physical Phenotype of Fetal Alcohol Spectrum Disorders from Childhood through Adolescence. 61
33320363 2021
15
Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders. 61
33533128 2021
16
Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain. 61
33189883 2021
17
Altered Resting-State Neural Oscillations and Spectral Power in Children with Fetal Alcohol Spectrum Disorder. 61
33164218 2021
18
Moderate prenatal alcohol exposure impairs cognitive control, but not attention, on a rodent touchscreen continuous performance task. 61
32144885 2021
19
Xenopus in revealing developmental toxicity and modeling human diseases. 61
33096388 2021
20
Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring. 61
32951039 2021
21
Psychopharmacological Treatments in Children with Fetal Alcohol Spectrum Disorders: A Review. 61
33502703 2021
22
White matter abnormalities in fetal alcohol spectrum disorders: Focus on axon growth and guidance. 61
33423552 2021
23
MANF is neuroprotective against ethanol-induced neurodegeneration through ameliorating ER stress. 61
33296727 2021
24
Nerve Growth Factor in Alcohol Use Disorders. 61
32348226 2021
25
Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders. 61
33446819 2021
26
Ethanol Gestational Exposure Impairs Vascular Development and Endothelial Potential to Control BBB-Associated Astrocyte Function in the Developing Cerebral Cortex. 61
33387302 2021
27
Hippocampal subfield abnormalities and memory functioning in children with fetal alcohol Spectrum disorders. 61
33232797 2021
28
Fetal alcohol spectrum disorders: an overview of current evidence and activities in the UK. 61
33441316 2021
29
Fetal Alcohol Exposure Alters BOLD Activation Patterns in Brain Regions Mediating the Interpretation of Facial Affect. 61
33220071 2021
30
Predictive value of indicators for identifying child maltreatment and intimate partner violence in coded electronic health records: a systematic review and meta-analysis. 61
32788201 2021
31
Calcitriol alleviates ethanol-induced hepatotoxicity via AMPK/mTOR-mediated autophagy. 61
33232716 2021
32
The prevalence, child characteristics, and maternal risk factors for the continuum of fetal alcohol spectrum disorders: A sixth population-based study in the same South African community. 61
33250379 2021
33
Molecules, Mechanisms, and Disorders of Self-Domestication: Keys for Understanding Emotional and Social Communication from an Evolutionary Perspective. 61
33375093 2020
34
Differential effects of maternal diets on birth outcomes and metabolic parameters in rats after ethanol consumption during pregnancy. 61
33355064 2020
35
Identifying fetal alcohol spectrum disorder among South African children at aged 1 and 5 years. 61
32956976 2020
36
A review of studies exploring fetal alcohol spectrum disorders through eye tracking measures. 61
32470497 2020
37
Pregnancy in women with physical and intellectual disability: psychiatric implications. 61
33349725 2020
38
Sleep and Cognition in Children with Fetal Alcohol Spectrum Disorders (FASD) and Children with Autism Spectrum Disorders (ASD). 61
33207724 2020
39
[Fetal alcohol spectrum disorders in adults]. 61
33104818 2020
40
Moderate prenatal alcohol exposure alters the number and function of GABAergic interneurons in the murine orbitofrontal cortex. 61
32540413 2020
41
Suggestibility and confabulation among individuals with Fetal Alcohol Spectrum Disorder: A review for criminal justice, forensic mental health, and legal interviewers. 61
33246222 2020
42
Hospitalizations and mortality among patients with fetal alcohol spectrum disorders: a prospective study. 61
33177533 2020
43
Alcohol use in pregnancy and its impact on the mother and child. 61
32149441 2020
44
In utero alcohol exposure exacerbates endothelial protease activity from pial microvessels and impairs GABA interneuron positioning. 61
32890773 2020
45
Fine-tuning the impairment argument. 61
33172908 2020
46
Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat. 61
32681672 2020
47
Multifactorial Genetic and Environmental Hedgehog Pathway Disruption Sensitizes Embryos to Alcohol-Induced Craniofacial Defects. 61
32767777 2020
48
Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids. 61
33051447 2020
49
Alcohol Increases Exosome Release from Microglia to Promote Complement C1q-Induced Cellular Death of Proopiomelanocortin Neurons in the Hypothalamus in a Rat Model of Fetal Alcohol Spectrum Disorders. 61
32887744 2020
50
Against the impairment argument: A reply to Hendricks. 61
32017158 2020

Variations for Fetal Alcohol Syndrome

Expression for Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for Fetal Alcohol Syndrome

Pathways related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 CYP2E1 ALDH2 AKR1A1 ADH7 ADH1B ADH1A
2
Show member pathways
12.53 CYP2E1 ALDH2 ADH7 ADH1B ADH1A
3
Show member pathways
12.21 ALDH2 ADH7 ADH1B ADH1A
4
Show member pathways
12.13 ALDH2 AKR1A1 ADH7 ADH1B ADH1A
5
Show member pathways
11.47 ALDH2 AKR1A1 ADH1B
6
Show member pathways
11.33 ADH7 ADH1B ADH1A
7
Show member pathways
10.68 ALDH2 ADH1B
8 10.55 ADH1B ADH1A
9
Show member pathways
10.51 ALDH2 AKR1A1 ADH7 ADH1B ADH1A
10
Show member pathways
10.36 CYP2E1 ADH1B
11
Show member pathways
10.31 CYP2E1 ALDH2 ADH1B

GO Terms for Fetal Alcohol Syndrome

Cellular components related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.1 L1CAM KCNJ2 CHRM3 CALB2 BDNF ADNP
2 cuticular plate GO:0032437 8.96 PVALB CALB2

Biological processes related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.5 KDM4C CYP2E1 ALDH2 AKR1A1 ADH7 ADH1B
2 retinol metabolic process GO:0042572 9.43 ADH7 ADH1B ADH1A
3 ethanol catabolic process GO:0006068 9.37 ALDH2 ADH7
4 retinoic acid metabolic process GO:0042573 9.33 ADH7 ADH1B ADH1A
5 alcohol metabolic process GO:0006066 9.32 ALDH2 ADH1A
6 ethanol oxidation GO:0006069 8.92 ALDH2 ADH7 ADH1B ADH1A

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.7 KDM4C CYP2E1 ALDH2 AKR1A1 ADH7 ADH1B
2 alcohol dehydrogenase (NAD) activity GO:0004022 9.26 ADH7 ADH1A
3 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.13 ADH7 ADH1B ADH1A
4 retinol dehydrogenase activity GO:0004745 8.92 AKR1A1 ADH7 ADH1B ADH1A

Sources for Fetal Alcohol Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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