Fetal Alcohol Syndrome (FAS)

Categories: Fetal diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Fetal Alcohol Syndrome

MalaCards integrated aliases for Fetal Alcohol Syndrome:

Name: Fetal Alcohol Syndrome 12 75 59 55 15 72 33
Fetal Alcohol Spectrum Disorders 59 43 3 72
Fetus or Newborn Affected by Alcohol Transmitted Via Placenta or Breast Milk 72
Alcohol-Related Neurodevelopmental Disorder 59
Alcohol Related Neurodevelopmental Disorder 72
Alcohol-Related Birth Defects 59
Alcohol Related Birth Defect 72
Arnd 59
Arbd 59
Fasd 59
Fas 59


Orphanet epidemiological data:

fetal alcohol syndrome
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Austria),1-9/100000 (Belgium),1-5/10000 (Germany),1-9/100000 (Hungary),1-9/100000 (Ireland),1-9/100000 (Italy),1-9/100000 (Norway),1-5/10000 (Switzerland),1-9/100000 (United Kingdom),1-5/10000 (France),1-9/1000000 (Poland),1-9/100000 (Spain),6-9/10000 (Ukraine); Age of onset: Antenatal,Neonatal; Age of death: any age;


External Ids:

Disease Ontology 12 DOID:0050665
ICD10 33 Q86.0
MESH via Orphanet 45 D005310
ICD10 via Orphanet 34 Q86.0
UMLS via Orphanet 73 C0015923 C0814154 C2985290 more
Orphanet 59 ORPHA1915
UMLS 72 C0015923 C0814154 C1542327 more

Summaries for Fetal Alcohol Syndrome

MedlinePlus : 43 Alcohol can harm your baby at any stage during a pregnancy. That includes the earliest stages, before you even know you are pregnant. Drinking during pregnancy can cause a group of conditions called fetal alcohol spectrum disorders (FASDs). Children who are born with FASD can have a mix of problems, such as medical, behavioral, educational, and social problems. The kinds of problems they have depend on which type of FASD they have. The problems could include Abnormal facial features, such as a smooth ridge between the nose and upper lip Small head size Shorter-than-average height Low body weight Poor coordination Hyperactive behavior Difficulty with attention and memory Learning disabilities and difficulty in school Speech and language delays Intellectual disability or low IQ Poor reasoning and judgment skills Sleep and sucking problems as a baby Vision or hearing problems Problems with the heart, kidneys, or bones Fetal alcohol syndrome (FAS) is the most serious type of FASD. People with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. Diagnosing FASD can be hard because there is no medical test for it. The health care provider will make a diagnosis by looking at the child's signs and symptoms, and will ask whether the mother drank alcohol during pregnancy. FASDs last a lifetime. There is no cure for FASDs, but treatments can help. These include medicines to help with some symptoms, medical care for health problems, behavior and education therapy, and parent training. A good treatment plan is specific to the child's problems. It should include close monitoring, follow-ups, and changes when needed. Certain "protective factors" can help reduce the effects of FASDs and help people who have them reach their full potential. They include Diagnosis before 6 years of age Loving, nurturing, and stable home environment during the school years Absence of violence around them Involvement in special education and social services There is no known safe amount of alcohol during pregnancy. To prevent FASDs, you should not drink alcohol while you are pregnant, or when you might get pregnant. Centers for Disease Control and Prevention

MalaCards based summary : Fetal Alcohol Syndrome, also known as fetal alcohol spectrum disorders, is related to fetal alcohol spectrum disorder and disease of mental health. An important gene associated with Fetal Alcohol Syndrome is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Glucose metabolism and Neuroscience. The drugs Epigallocatechin gallate and Epigallocatechin have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related phenotypes are intellectual disability and behavioral abnormality

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

CDC : 3 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose mother drank alcohol during pregnancy. FASDs are preventable if a woman does not drink alcohol during pregnancy.

Wikipedia : 75 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose... more...

Related Diseases for Fetal Alcohol Syndrome

Diseases in the Fetal Alcohol Syndrome family:

Fetal Alcohol Spectrum Disorder

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1211)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol spectrum disorder 31.2 RBP1 PFAS GRIN2B AKR1A1 ADH7
2 disease of mental health 29.4 SLC27A5 PVALB GRIN2B
3 status epilepticus 29.4 PVALB GRIN2B GFAP
4 alcohol dependence 29.3 GRIN2B ALDH2 AKR1A1 ADH7 ADH1B
5 ganglioneuroma 29.2 VIP GFAP
6 partial fetal alcohol syndrome 12.8
7 autoimmune lymphoproliferative syndrome 12.5
8 fanconi anemia, complementation group a 12.4
9 friedreich ataxia 1 12.1
10 graft-versus-host disease 12.1
11 dianzani autoimmune lymphoproliferative disease 12.0
12 alcohol-related birth defect 11.9
13 lung cancer 11.8
14 colorectal cancer 11.8
15 lymphoproliferative syndrome 11.7
16 breast cancer 11.7
17 prostate cancer 11.7
18 hepatitis c 11.7
19 lymphoma 11.7
20 mycosis fungoides 11.7
21 squamous cell carcinoma 11.7
22 autoimmune disease 11.6
23 hashimoto thyroiditis 11.6
24 viral hepatitis 11.6
25 lymphopenia 11.6
26 silicosis 11.6
27 autoimmune hepatitis 11.6
28 alcohol use disorder 11.6
29 systemic lupus erythematosus 11.6
30 fanconi anemia, complementation group d2 11.6
31 splenomegaly 11.6
32 fanconi anemia, complementation group i 11.6
33 graves' disease 11.6
34 fanconi anemia, complementation group l 11.6
35 myelodysplastic syndrome 11.6
36 aplastic anemia 11.6
37 burkitt lymphoma 11.6
38 fanconi anemia, complementation group j 11.6
39 fanconi anemia, complementation group d1 11.6
40 cowpox 11.6
41 fanconi anemia, complementation group n 11.6
42 alzheimer disease 11.6
43 fanconi anemia, complementation group b 11.6
44 severe cutaneous adverse reaction 11.6
45 fanconi anemia, complementation group o 11.5
46 pneumoconiosis 11.5
47 diabetes mellitus 11.5
48 lymphomatoid papulosis 11.5
49 asthma 11.5
50 cytomegalovirus infection 11.5

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:

Diseases related to Fetal Alcohol Syndrome

Symptoms & Phenotypes for Fetal Alcohol Syndrome

Human phenotypes related to Fetal Alcohol Syndrome:

59 32 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intellectual disability 59 32 hallmark (90%) Very frequent (99-80%) HP:0001249
2 behavioral abnormality 59 32 hallmark (90%) Very frequent (99-80%) HP:0000708
3 global developmental delay 59 32 hallmark (90%) Very frequent (99-80%) HP:0001263
4 microcephaly 59 32 hallmark (90%) Very frequent (99-80%) HP:0000252
5 short stature 59 32 hallmark (90%) Very frequent (99-80%) HP:0004322
6 cognitive impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0100543
7 intrauterine growth retardation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001511
8 specific learning disability 59 32 hallmark (90%) Very frequent (99-80%) HP:0001328
9 telecanthus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000506
10 narrow face 59 32 hallmark (90%) Very frequent (99-80%) HP:0000275
11 ptosis 59 32 frequent (33%) Frequent (79-30%) HP:0000508
12 joint stiffness 59 32 frequent (33%) Frequent (79-30%) HP:0001387
13 short nose 59 32 frequent (33%) Frequent (79-30%) HP:0003196
14 smooth philtrum 59 32 frequent (33%) Frequent (79-30%) HP:0000319
15 anteverted nares 59 32 frequent (33%) Frequent (79-30%) HP:0000463
16 micrognathia 59 32 frequent (33%) Frequent (79-30%) HP:0000347
17 strabismus 59 32 frequent (33%) Frequent (79-30%) HP:0000486
18 epicanthus 59 32 frequent (33%) Frequent (79-30%) HP:0000286
19 microdontia 59 32 frequent (33%) Frequent (79-30%) HP:0000691
20 biparietal narrowing 59 32 frequent (33%) Frequent (79-30%) HP:0004422
21 abnormal dermatoglyphics 59 32 frequent (33%) Frequent (79-30%) HP:0007477
22 atrial septal defect 59 32 frequent (33%) Frequent (79-30%) HP:0001631
23 abnormality of immune system physiology 59 32 frequent (33%) Frequent (79-30%) HP:0010978
24 non-midline cleft lip 59 32 frequent (33%) Frequent (79-30%) HP:0100335
25 microphthalmia 59 32 frequent (33%) Frequent (79-30%) HP:0000568
26 visceral angiomatosis 59 32 frequent (33%) Frequent (79-30%) HP:0100761
27 low-set, posteriorly rotated ears 59 32 frequent (33%) Frequent (79-30%) HP:0000368
28 thin upper lip vermilion 59 32 frequent (33%) Frequent (79-30%) HP:0000219
29 vertebral segmentation defect 59 32 frequent (33%) Frequent (79-30%) HP:0003422
30 cleft palate 59 32 occasional (7.5%) Occasional (29-5%) HP:0000175
31 generalized hirsutism 59 32 occasional (7.5%) Occasional (29-5%) HP:0002230
32 congenital diaphragmatic hernia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000776

MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.1 ADH7 AKR1A1 ALDH2 CHRM3 GFAP GRIN2B
2 behavior/neurological MP:0005386 10.07 ADH7 ALDH2 CHRM3 GFAP GRIN2B KCNJ2
3 homeostasis/metabolism MP:0005376 10 ADH7 AKR1A1 ALDH2 CHRM3 GFAP GRIN2B
4 mortality/aging MP:0010768 9.9 ADH7 AKR1A1 ALDH2 GFAP GRIN2B KCNJ2
5 pigmentation MP:0001186 9.26 ALDH2 L1CAM PFAS RBP1
6 vision/eye MP:0005391 9.23 ALDH2 CHRM3 GFAP L1CAM PFAS PVALB

Drugs & Therapeutics for Fetal Alcohol Syndrome

Drugs for Fetal Alcohol Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Epigallocatechin gallate Investigational Phase 2, Phase 3 989-51-5 65064
Epigallocatechin Experimental, Investigational Phase 2, Phase 3 970-74-1 72277
3 Neuroprotective Agents Phase 2, Phase 3
4 Antioxidants Phase 2, Phase 3
5 Protective Agents Phase 2, Phase 3
6 Neurotransmitter Agents Phase 3
7 Adrenergic Agents Phase 3
8 Neurotransmitter Uptake Inhibitors Phase 3
9 Atomoxetine Hydrochloride Phase 3
Choline Approved, Nutraceutical Phase 2 62-49-7 305
11 Gastrointestinal Agents Phase 2
12 Nootropic Agents Phase 2
13 Lipid Regulating Agents Phase 2
14 Hypolipidemic Agents Phase 2
15 Antimetabolites Phase 2
Nicotine Approved 54-11-5 942 89594
tannic acid Approved 1401-55-4
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
Nitric Oxide Approved 10102-43-9 145068
Ethanol Approved 64-17-5 702
21 Micronutrients
22 Trace Elements
23 Vitamins
24 Nutrients
25 Anti-Infective Agents, Local
26 Central Nervous System Depressants
27 Anti-Infective Agents

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Epigallocatechin Gallate (EGCG) as Therapeutic Tool to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children Unknown status NCT02558933 Phase 2, Phase 3
2 An Open-label Study of the Long Term Tolerability and Safety of Atomoxetine in Treating the Inattention, Impulsivity and Hyperactivity in Children With Fetal-Alcohol Syndrome or Effects. Completed NCT00418262 Phase 3 Atomoxetine
3 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
4 Neurocognitive Habilitation for Children With FAS/ARND Completed NCT00164346 Phase 1, Phase 2
5 Fetal Alcohol Syndrome/ARND Research Consortion-Oklahoma Completed NCT00164554 Phase 1, Phase 2
6 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2 Choline bitartrate
7 Study to Investigate the Effectiveness of a Math Intervention for Children With Fetal Alcohol Syndrome or Related Condition Completed NCT00164229 Phase 1, Phase 2
8 A Media Based Motivational Intervention to Reduce Alcohol Exposed Pregnancies (AEPs) Completed NCT00219336 Phase 2
9 Intervening With Children/Adolescents With FAS/ARND Completed NCT00164528 Phase 1, Phase 2
10 Assisting Children With Prenatal Alcohol Exposure in Developing Peer Friendships Completed NCT00164307 Phase 1, Phase 2
11 Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Recruiting NCT02735473 Phase 2 Choline bitartrate;Placebo
12 Neighborhood Alcohol & HIV Prevention in South African Townships (Philani) Active, not recruiting NCT00996528 Phase 2
13 A Study of the Efficacy of Atomoxetine in Treating the Inattention, Impulsivity and Hyperactivity in Children With Fetal Alcohol Syndrome or Effects Completed NCT00417794 Phase 1 Strattera;Placebo
14 Computer-delivered SBIRT for Alcohol Use in Pregnancy: Planning a Stage II Trial Completed NCT01643044 Phase 1
15 Effects of Hyperbaric Oxygen Therapy on Cognitive Function on Autistic Spectrum Disordered Children Unknown status NCT00631215
16 Strongest Families FASD: Parent Training for Challenging Behaviour in Children With Fetal Alcohol Spectrum Disorder (FASD) Completed NCT02210455
17 Preventing FAS/ARND in Russian Children Completed NCT01961050
18 Preventing FAS/ARND in Russian Children/Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603
19 Reducing Alcohol Exposed Pregnancy Risk Completed NCT01446653
20 Development of Education Materials for Prevention of Fetal Alcohol Syndrome (FAS) in Russia Completed NCT01971398
21 "Brief Alcohol Intervention: The Healthy Moms Project." Completed NCT00244062
22 Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention Completed NCT02457676
23 Neuromodulation Augmented Cognitive Remediation to Improve Executive Dysfunction in Fetal Alcohol Spectrum Disorder (FASD) Completed NCT03361293
24 Dog-Assisted Therapy for Children and Adolescents With FASD: a Randomized Controlled Pilot Study Completed NCT04038164
25 Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With Fetal Alcohol Spectrum Disorder (FASD) or At-risk for FASD: A Randomized Controlled Field Trial Completed NCT01536184
26 Prevention of Fetal Alcohol Damage Using Maternal Blood Markers Completed NCT00696085
27 A Randomized Clinical Trial of the Contraception and Alcohol Risk Reduction Internet Intervention to Reduce AEP Risk in Community Women Completed NCT02128880
28 Early Identification of Affected Children and Nutritional Risk Factors for FASD in Ukraine Completed NCT03782935
29 Self-Regulation in Adolescents With FASD: The Efficacy of a Targeted Intervention Completed NCT02912962
30 Modeling and Testing Change in Mental Abilities in Childhood Through Computer-based Interventions Completed NCT02459873
31 Effects of Hyperbaric Oxygen Therapy on Clinical Symptoms and Markers of Inflammation and Oxidative Stress in Autistic Children: A Pilot Study Completed NCT00324909 Hyperbaric Oxygen Therapy
32 Face Anthropometric Pattern Recognition Technology, Based on 3D Reconstruction Technology, for Computer Aided Diagnosis of Human Genetic Disorders. Multicenter Collaborative Study. Completed NCT00705055
33 Comprehensive Program for Youth Mental Health Completed NCT02169960
34 A Prospective, Randomized, Double-Blind, Controlled Study on the Clinical Effects of Hyperbaric Therapy in Autistic Children Completed NCT00335790
35 Augmented Biofeedback Training Combined With Physical Therapy Program Improves Visual-motor Integration, Visual Perception and Motor Coordination in Children With Spastic Hemiplegic Cerebral Palsy: a Randomized Control Trial Completed NCT03626077
36 In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions Recruiting NCT03371641
37 The Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Life Span: Continuing Prevention and Longitudinal Epidemiology Recruiting NCT04026620
38 Parent Emotion Socialization and Child Emotion Regulation in FASD Recruiting NCT03524664
39 Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum Disorder Recruiting NCT03494738
40 Newborn Phosphatidylethanol Screening to Detect Fetal Alcohol Exposure in Uruguay Recruiting NCT02600624
41 Fetal Alcohol Spectrum Disorder-Is This a Ciliopathy? Recruiting NCT03802708
42 Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial Recruiting NCT03342495
43 Native-Changing High-risk Alcohol Use and Increasing Contraception Effectiveness Study Recruiting NCT03930342
44 The Effectiveness of an Educational Program on Parenting Stress and Coping Mechanism Among Parents of Children With Autism Spectrum Disorder in Amman, Jordan Recruiting NCT03805828
45 Effectiveness of Visual and Auditory Feedback on Eye-hand Coordination in Children With Hemiplegic Cerebral Palsy Recruiting NCT03742999
46 Behavioral Exploration of Cognitive and Emotional Alterations in Adult Individuals Exposed to Alcohol During the Prenatal Period Active, not recruiting NCT03793920
47 Prevention of Fetal Alcohol Spectrum Disorder (FASD) by the Use of Technology Enrolling by invitation NCT02759874
48 Alcohol Related Brain Damage: Exploring Virtual Reality Based Cognitive Function Assessment and EEG Biomarkers. A Pilot Study Not yet recruiting NCT03826238
49 CHILD-BRIGHT READYorNot[TM] Brain-Based Disabilities Trial Not yet recruiting NCT03852550
50 Development, Implementation, and Evaluation of an Internet-based Behavioural Sleep Intervention for Children With NDD and Insomnia Not yet recruiting NCT02694003

Search NIH Clinical Center for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

Anatomical Context for Fetal Alcohol Syndrome

MalaCards organs/tissues related to Fetal Alcohol Syndrome:

Brain, Eye, Testes, Heart, Cortex, Bone, Placenta

Publications for Fetal Alcohol Syndrome

Articles related to Fetal Alcohol Syndrome:

(show top 50) (show all 2964)
# Title Authors PMID Year
Prenatal alcohol exposure and facial morphology in a UK cohort. 38 17
30772781 2019
Exon level machine learning analyses elucidate novel candidate miRNA targets in an avian model of fetal alcohol spectrum disorder. 17
30973878 2019
Policymakers' Perspectives Towards Developing a Guideline to Inform Policy on Fetal Alcohol Spectrum Disorder: A Qualitative Study. 17
30884766 2019
Effect of gestational ethanol exposure on parvalbumin and calretinin expressing hippocampal neurons in a chick model of fetal alcohol syndrome. 9 38
19251116 2009
Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview. 9 38
17618743 2007
The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome. 9 38
7748347 1993
A hypothetical mechanism for fetal alcohol syndrome involving ethanol inhibition of retinoic acid synthesis at the alcohol dehydrogenase step. 9 38
1877746 1991
Distinct functions of endogenous cannabinoid system in alcohol abuse disorders. 38
31265740 2019
Social deficits following embryonic ethanol exposure arise in post-larval zebrafish. 38
30178621 2019
Facebook ads to the rescue? Recruiting a hard to reach population into an Internet-based behavioral health intervention trial. 38
31080751 2019
Advocacy-Related Information Distortion: The Case of Fetal Alcohol Spectrum Disorders. 38
31288558 2019
Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder. 38
31160204 2019
6-month Follow up of the Families on Track Intervention Pilot Trial for Children with Fetal Alcohol Spectrum Disorders and Their Families. 38
31408192 2019
Impaired bidirectional synaptic plasticity in juvenile offspring following prenatal ethanol exposure. 38
31386206 2019
Chronic Ethanol Exposure Alters DNA Methylation in Neural Stem Cells: Role of Mouse Strain and Sex. 38
31414368 2019
Early life alcohol exposure primes hypothalamic microglia to later-life hypersensitivity to immune stress: possible epigenetic mechanism. 38
30737481 2019
Prenatal Alcohol Screening During Pregnancy by Midwives and Nurses. 38
31184777 2019
Coordinated Tcf7l2 regulation in a mouse model implicates Wnt signaling in fetal alcohol spectrum disorders. 38
30398926 2019
Association Analysis: Fetal Alcohol Spectrum Disorder and Hypertension Status in Children and Adolescents. 38
31166027 2019
Relation between adaptive function and IQ among youth with histories of heavy prenatal alcohol exposure. 38
30719847 2019
Hippocampal transcriptome reveals novel targets of FASD pathogenesis. 38
31140755 2019
Increased Maternal Care Rescues Altered Reinstatement Responding Following Moderate Prenatal Alcohol Exposure. 38
31318985 2019
Differentially sensitive neuronal subpopulations in the central nervous system and the formation of hindbrain heterotopias in ethanol-exposed zebrafish. 38
30793540 2019
DHA supplementation during prenatal ethanol exposure alters the expression of fetal rat liver genes involved in oxidative stress regulation. 38
30521352 2019
Comparisons of the BRIEF parental report and neuropsychological clinical tests of executive function in Fetal Alcohol Spectrum Disorders: data from the UK national specialist clinic. 38
30251596 2019
Nucleus reuniens of the midline thalamus of a rat is specifically damaged after early postnatal alcohol exposure. 38
31095109 2019
Sulforaphane protects against ethanol-induced apoptosis in neural crest cells through restoring epithelial-mesenchymal transition by epigenetically modulating the expression of Snail1. 38
31295528 2019
3D-Analysis of Mouth, Nose and Eye Parameters in Children with Fetal Alcohol Syndrome (FAS). 38
31315192 2019
Differential neuroimaging indices in prefrontal white matter in prenatal alcohol-associated ADHD versus idiopathic ADHD. 38
30694611 2019
Adverse Health Outcomes in Offspring Associated With Fetal Alcohol Exposure: A Systematic Review of Clinical and Preclinical Studies With a Focus on Metabolic and Body Composition Outcomes. 38
31063217 2019
Retinoic acid signaling reduction recapitulates the effects of alcohol on embryo size. 38
30672660 2019
The impairment argument for the immorality of abortion: A reply. 38
30945321 2019
Oxidative stress and DNA damage in the mechanism of fetal alcohol spectrum disorders. 38
31033255 2019
Fetal alcohol spectrum disorder prevention program: SBIRT's role in averting fetal alcohol spectrum disorders. 38
31334924 2019
Nurses and Fetal Alcohol Spectrum Disorders Prevention. 38
31045467 2019
Fetal alcohol spectrum disorders: Mechanisms, diagnosis, treatment, and prevention. 38
31334923 2019
Suicide risk in adolescents with fetal alcohol spectrum disorders. 38
30677250 2019
Prevalence of fetal alcohol spectrum disorder among special subpopulations: a systematic review and meta-analysis. 38
30831001 2019
Auxo-endocrinological features in a cohort of internationally adopted children in Italy. 38
30783950 2019
MicroRNA-34a mediates ethanol-induced impairment of neural differentiation of neural crest cells by targeting autophagy-related gene 9a. 38
31247197 2019
Alcohol Consumption and Smoking During Pregnancy Alters Maternal Plasma Fatty Acid Composition: Association with Fetal Alcohol Spectrum Disorders (P11-028-19). 38
31224760 2019
Untargeted Metabolomics Analysis of Maternal Plasma from Pregnant C57Bl/6J Mice Identifies Significant Metabolic Changes in Response to Gestational Alcohol Exposure (OR26-01-19). 38
31225007 2019
Statistical sensitivity analysis for the estimation of fetal alcohol spectrum disorders prevalence. 38
30959091 2019
Corrigendum: Fetal Alcohol Syndrome Disorder - diminished responsibility and mitigation of sentence. 38
31112032 2019
Proceedings of the 2018 Annual Meeting of the Fetal Alcohol Spectrum Disorders Study Group. 38
31173861 2019
Fetal Alcohol Spectrum Disorders: A Review of the Neurobehavioral Deficits Associated With Prenatal Alcohol Exposure. 38
30964197 2019
Maternal alcohol use and children's emotional and cognitive outcomes in rural South Africa. 38
31266581 2019
Are Low-to-Moderate Average Alcohol Consumption and Isolated Episodes of Binge Drinking in Early Pregnancy Associated with Facial Features Related to Fetal Alcohol Syndrome in 5-Year-Old Children? 38
30977899 2019
The Prevalence of Fetal Alcohol Spectrum Disorders in An American Indian Community. 38
31226736 2019
Ethanol Exposure In Utero Disrupts Radial Migration and Pyramidal Cell Development in the Somatosensory Cortex. 38
29688328 2019

Variations for Fetal Alcohol Syndrome

Expression for Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for Fetal Alcohol Syndrome

Pathways related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
11.47 ALDH2 AKR1A1 ADH1B
Show member pathways
Show member pathways
10.33 ALDH2 ADH1B
Show member pathways
10.13 ALDH2 ADH1B

GO Terms for Fetal Alcohol Syndrome

Biological processes related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.72 KDM4C ALDH2 AKR1A1 ADH7 ADH1B
2 retinol metabolic process GO:0042572 9.37 RBP1 ADH7
3 retinoic acid metabolic process GO:0042573 9.16 RBP1 ADH7
4 axon development GO:0061564 8.96 L1CAM
5 ethanol catabolic process GO:0006068 8.96 ALDH2 ADH7
6 ethanol oxidation GO:0006069 8.8 ALDH2 ADH7 ADH1B

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.35 KDM4C ALDH2 AKR1A1 ADH7 ADH1B
2 retinol binding GO:0019841 9.16 RBP1 ADH7
3 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.62 ADH7 ADH1B

Sources for Fetal Alcohol Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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