FAS
MCID: FTL001
MIFTS: 55

Fetal Alcohol Syndrome (FAS)

Categories: Fetal diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Fetal Alcohol Syndrome

MalaCards integrated aliases for Fetal Alcohol Syndrome:

Name: Fetal Alcohol Syndrome 12 74 58 54 15 71 32
Fetal Alcohol Spectrum Disorders 58 42 3 71
Fetus or Newborn Affected by Alcohol Transmitted Via Placenta or Breast Milk 71
Alcohol-Related Neurodevelopmental Disorder 58
Alcohol Related Neurodevelopmental Disorder 71
Alcohol-Related Birth Defects 58
Alcohol Related Birth Defect 71
Arnd 58
Arbd 58
Fasd 58
Fas 58

Characteristics:

Orphanet epidemiological data:

58
fetal alcohol syndrome
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Austria),1-9/100000 (Belgium),1-5/10000 (Germany),1-9/100000 (Hungary),1-9/100000 (Ireland),1-9/100000 (Italy),1-9/100000 (Norway),1-5/10000 (Switzerland),1-9/100000 (United Kingdom),1-5/10000 (France),1-9/1000000 (Poland),1-9/100000 (Spain),6-9/10000 (Ukraine); Age of onset: Antenatal,Neonatal; Age of death: any age;

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis
Teratologic disorders


External Ids:

Disease Ontology 12 DOID:0050665
ICD10 32 Q86.0
MESH via Orphanet 44 D005310
ICD10 via Orphanet 33 Q86.0
UMLS via Orphanet 72 C0015923 C0814154 C2985290 more
Orphanet 58 ORPHA1915
UMLS 71 C0015923 C0814154 C1542327 more

Summaries for Fetal Alcohol Syndrome

MedlinePlus : 42 Alcohol can harm your baby at any stage during a pregnancy. That includes the earliest stages, before you even know you are pregnant. Drinking during pregnancy can cause a group of conditions called fetal alcohol spectrum disorders (FASDs). Children who are born with FASD can have a mix of problems, such as medical, behavioral, educational, and social problems. The kinds of problems they have depend on which type of FASD they have. The problems could include Abnormal facial features, such as a smooth ridge between the nose and upper lip Small head size Shorter-than-average height Low body weight Poor coordination Hyperactive behavior Difficulty with attention and memory Learning disabilities and difficulty in school Speech and language delays Intellectual disability or low IQ Poor reasoning and judgment skills Sleep and sucking problems as a baby Vision or hearing problems Problems with the heart, kidneys, or bones Fetal alcohol syndrome (FAS) is the most serious type of FASD. People with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. Diagnosing FASD can be hard because there is no medical test for it. The health care provider will make a diagnosis by looking at the child's signs and symptoms, and will ask whether the mother drank alcohol during pregnancy. FASDs last a lifetime. There is no cure for FASDs, but treatments can help. These include medicines to help with some symptoms, medical care for health problems, behavior and education therapy, and parent training. A good treatment plan is specific to the child's problems. It should include close monitoring, follow-ups, and changes when needed. Certain "protective factors" can help reduce the effects of FASDs and help people who have them reach their full potential. They include Diagnosis before 6 years of age Loving, nurturing, and stable home environment during the school years Absence of violence around them Involvement in special education and social services There is no known safe amount of alcohol during pregnancy. To prevent FASDs, you should not drink alcohol while you are pregnant, or when you might get pregnant. Centers for Disease Control and Prevention

MalaCards based summary : Fetal Alcohol Syndrome, also known as fetal alcohol spectrum disorders, is related to alcohol-related birth defect and renal cell carcinoma, nonpapillary. An important gene associated with Fetal Alcohol Syndrome is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Fatty Acyl-CoA Biosynthesis and Glucose metabolism. The drugs Neurotransmitter Agents and Atomoxetine Hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and bone, and related phenotypes are intellectual disability and global developmental delay

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

CDC : 3 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose mother drank alcohol during pregnancy. FASDs are preventable if a woman does not drink alcohol during pregnancy.

Wikipedia : 74 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose... more...

Related Diseases for Fetal Alcohol Syndrome

Diseases in the Fetal Alcohol Syndrome family:

Fetal Alcohol Spectrum Disorder

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1242)
# Related Disease Score Top Affiliating Genes
1 alcohol-related birth defect 33.5 SLC27A5 PFAS ADH1B
2 renal cell carcinoma, nonpapillary 32.0 SLC27A5 PVALB MIR9-1 KDM4C H2AC18 CALB2
3 alcohol use disorder 31.9 SLC27A5 KDM4C H2AC18 GRIN2B BDNF ALDH2
4 fetal alcohol spectrum disorder 31.7 SLC27A5 PVALB PFAS MIR9-1 KDM4C H2AC18
5 alcohol-related neurodevelopmental disorder 30.6 PFAS GRIN2B
6 alcohol dependence 30.5 GRIN2B BDNF ALDH2 AKR1A1 ADH7 ADH1B
7 substance abuse 30.3 SLC27A5 H2AC18 BDNF ALDH2 ADH1B
8 testicular disease 30.3 KDM4C H2AC18 CALB2
9 traumatic brain injury 30.3 GFAP BDNF
10 status epilepticus 30.1 PVALB GRIN2B GFAP CALB2 BDNF
11 disease of mental health 30.1 PVALB MIR9-1 KDM4C H2AC18 GRIN2B BDNF
12 drug dependence 30.0 BDNF ADH7 ADH1B
13 alcoholic liver cirrhosis 30.0 ALDH2 AKR1A1 ADH1B
14 mental depression 30.0 MIR9-1 H2AC18 GRIN2B BDNF
15 grade iii astrocytoma 29.9 KDM4C H2AC18 GFAP
16 ocular dominance 29.9 GRIN2B BDNF
17 scrapie 29.9 PVALB MIR9-1 GFAP
18 gangliocytoma 29.9 PVALB GFAP
19 psychotic disorder 29.9 PVALB MIR9-1 H2AC18 GRIN2B BDNF
20 supranuclear palsy, progressive, 1 29.8 PVALB MIR9-1 ADNP
21 amyotrophic lateral sclerosis 1 29.7 PVALB MIR9-1 H2AC18 GFAP CALB2 BDNF
22 fragile x syndrome 29.7 MIR9-1 H2AC18 GRIN2B BDNF
23 nervous system disease 29.5 MIR9-1 KDM4C H2AC18 BDNF
24 autism 29.4 KDM4C GRIN2B GFAP CALB2 BDNF ADNP
25 migraine with or without aura 1 29.4 VIP H2AC18 GRIN2B BDNF
26 eye disease 29.3 SLC27A5 MIR9-1 KDM4C H2AC18 GFAP BDNF
27 schizophrenia 29.1 PVALB MIR9-1 GRIN2B GFAP CALB2 BDNF
28 pervasive developmental disorder 28.9 PVALB MIR9-1 KDM4C H2AC18 GRIN2B GFAP
29 partial fetal alcohol syndrome 12.8
30 fanconi anemia, complementation group a 12.6
31 autoimmune lymphoproliferative syndrome 12.4
32 friedreich ataxia 12.1
33 graft-versus-host disease 12.0
34 dianzani autoimmune lymphoproliferative disease 11.9
35 adult t-cell leukemia 11.9
36 lung cancer 11.8
37 colorectal cancer 11.7
38 mycosis fungoides 11.7
39 lymphoproliferative syndrome 11.7
40 breast cancer 11.6
41 prostate cancer 11.6
42 ovarian cancer 11.6
43 gastric cancer 11.6
44 hepatitis c 11.6
45 caspase 8 deficiency 11.6
46 lymphoma 11.6
47 autoimmune disease 11.6
48 systemic lupus erythematosus 11.6
49 squamous cell carcinoma 11.6
50 fanconi anemia, complementation group d2 11.6

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to Fetal Alcohol Syndrome

Symptoms & Phenotypes for Fetal Alcohol Syndrome

Human phenotypes related to Fetal Alcohol Syndrome:

58 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intellectual disability 58 31 hallmark (90%) Very frequent (99-80%) HP:0001249
2 global developmental delay 58 31 hallmark (90%) Very frequent (99-80%) HP:0001263
3 behavioral abnormality 58 31 hallmark (90%) Very frequent (99-80%) HP:0000708
4 short stature 58 31 hallmark (90%) Very frequent (99-80%) HP:0004322
5 intrauterine growth retardation 58 31 hallmark (90%) Very frequent (99-80%) HP:0001511
6 microcephaly 58 31 hallmark (90%) Very frequent (99-80%) HP:0000252
7 cognitive impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0100543
8 specific learning disability 58 31 hallmark (90%) Very frequent (99-80%) HP:0001328
9 telecanthus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000506
10 narrow face 58 31 hallmark (90%) Very frequent (99-80%) HP:0000275
11 ptosis 58 31 frequent (33%) Frequent (79-30%) HP:0000508
12 joint stiffness 58 31 frequent (33%) Frequent (79-30%) HP:0001387
13 short nose 58 31 frequent (33%) Frequent (79-30%) HP:0003196
14 micrognathia 58 31 frequent (33%) Frequent (79-30%) HP:0000347
15 smooth philtrum 58 31 frequent (33%) Frequent (79-30%) HP:0000319
16 anteverted nares 58 31 frequent (33%) Frequent (79-30%) HP:0000463
17 strabismus 58 31 frequent (33%) Frequent (79-30%) HP:0000486
18 epicanthus 58 31 frequent (33%) Frequent (79-30%) HP:0000286
19 microdontia 58 31 frequent (33%) Frequent (79-30%) HP:0000691
20 biparietal narrowing 58 31 frequent (33%) Frequent (79-30%) HP:0004422
21 abnormal dermatoglyphics 58 31 frequent (33%) Frequent (79-30%) HP:0007477
22 atrial septal defect 58 31 frequent (33%) Frequent (79-30%) HP:0001631
23 abnormality of immune system physiology 58 31 frequent (33%) Frequent (79-30%) HP:0010978
24 non-midline cleft lip 58 31 frequent (33%) Frequent (79-30%) HP:0100335
25 microphthalmia 58 31 frequent (33%) Frequent (79-30%) HP:0000568
26 thin upper lip vermilion 58 31 frequent (33%) Frequent (79-30%) HP:0000219
27 visceral angiomatosis 58 31 frequent (33%) Frequent (79-30%) HP:0100761
28 low-set, posteriorly rotated ears 58 31 frequent (33%) Frequent (79-30%) HP:0000368
29 vertebral segmentation defect 58 31 frequent (33%) Frequent (79-30%) HP:0003422
30 cleft palate 58 31 occasional (7.5%) Occasional (29-5%) HP:0000175
31 generalized hirsutism 58 31 occasional (7.5%) Occasional (29-5%) HP:0002230
32 congenital diaphragmatic hernia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000776

MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.36 ADH7 ALDH2 BDNF CALB2 CHRM3 GFAP

Drugs & Therapeutics for Fetal Alcohol Syndrome

Drugs for Fetal Alcohol Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Neurotransmitter Agents Phase 3
2 Atomoxetine Hydrochloride Phase 3
3 Adrenergic Agents Phase 3
4
Choline Approved, Nutraceutical Phase 2 62-49-7 305
5 Gastrointestinal Agents Phase 2
6 Hypolipidemic Agents Phase 2
7 Nootropic Agents Phase 2
8 Lipid Regulating Agents Phase 2
9 Antimetabolites Phase 2
10
Nicotine Approved 54-11-5 942 89594
11
tannic acid Approved 1401-55-4
12
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
13
Nitric Oxide Approved 10102-43-9 145068
14
leucovorin Approved 58-05-9 6006 143
15
Ethanol Approved 64-17-5 702
16
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
17
Epigallocatechin Experimental, Investigational 970-74-1 72277
18
Epigallocatechin gallate Investigational 989-51-5 65064
19 Antioxidants
20 Protective Agents
21 Neuroprotective Agents
22 Central Nervous System Depressants
23 Anti-Infective Agents, Local
24 Anti-Infective Agents
25 Vitamins
26 Trace Elements
27 Micronutrients
28 Nutrients
29 Hematinics
30 Vitamin B Complex
31 Vitamin B9
32 Folate
33 Tetrahydrofolates

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 An Open-label Study of the Long Term Tolerability and Safety of Atomoxetine in Treating the Inattention, Impulsivity and Hyperactivity in Children With Fetal-Alcohol Syndrome or Effects. Completed NCT00418262 Phase 3 Atomoxetine
2 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
3 Neurocognitive Habilitation for Children With FAS/ARND Completed NCT00164346 Phase 1, Phase 2
4 Fetal Alcohol Syndrome/ARND Research Consortion-Oklahoma Completed NCT00164554 Phase 1, Phase 2
5 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2 Choline bitartrate
6 Study to Investigate the Effectiveness of a Math Intervention for Children With Fetal Alcohol Syndrome or Related Condition Completed NCT00164229 Phase 1, Phase 2
7 A Media Based Motivational Intervention to Reduce Alcohol Exposed Pregnancies (AEPs) Completed NCT00219336 Phase 2
8 Intervening With Children/Adolescents With FAS/ARND Completed NCT00164528 Phase 1, Phase 2
9 Project CHOICES Efficacy Study for Preventing Alcohol-Exposed Pregnancies Completed NCT00153478 Phase 2
10 Assisting Children With Prenatal Alcohol Exposure in Developing Peer Friendships Completed NCT00164307 Phase 1, Phase 2
11 Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Recruiting NCT02735473 Phase 2 Choline bitartrate;Placebo
12 Neighborhood Alcohol & HIV Prevention in South African Townships (Philani) Active, not recruiting NCT00996528 Phase 2
13 A Study of the Efficacy of Atomoxetine in Treating the Inattention, Impulsivity and Hyperactivity in Children With Fetal Alcohol Syndrome or Effects Completed NCT00417794 Phase 1 Strattera;Placebo
14 Computer-delivered SBIRT for Alcohol Use in Pregnancy: Planning a Stage II Trial Completed NCT01643044 Phase 1
15 Prevention of Fetal Alcohol Spectrum Disorder (FASD) by the Use of Technology Unknown status NCT02759874
16 Effects of Hyperbaric Oxygen Therapy on Cognitive Function on Autistic Spectrum Disordered Children Unknown status NCT00631215
17 Strongest Families FASD: Parent Training for Challenging Behaviour in Children With Fetal Alcohol Spectrum Disorder (FASD) Completed NCT02210455
18 Preventing FAS/ARND in Russian Children Completed NCT01961050
19 Preventing FAS/ARND in Russian Children/Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603
20 Reducing Alcohol Exposed Pregnancy Risk Completed NCT01446653
21 Development of Education Materials for Prevention of Fetal Alcohol Syndrome (FAS) in Russia Completed NCT01971398
22 "Brief Alcohol Intervention: The Healthy Moms Project." Completed NCT00244062
23 Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention Completed NCT02457676
24 Neuromodulation Augmented Cognitive Remediation to Improve Executive Dysfunction in Fetal Alcohol Spectrum Disorder (FASD) Completed NCT03361293
25 Dog-Assisted Therapy for Children and Adolescents With FASD: a Randomized Controlled Pilot Study Completed NCT04038164
26 Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With Fetal Alcohol Spectrum Disorder (FASD) or At-risk for FASD: A Randomized Controlled Field Trial Completed NCT01536184
27 Prevention of Fetal Alcohol Damage Using Maternal Blood Markers Completed NCT00696085
28 A Randomized Clinical Trial of the Contraception and Alcohol Risk Reduction Internet Intervention to Reduce AEP Risk in Community Women Completed NCT02128880
29 Epigallocatechin Gallate (EGCG) as Therapeutic Tool to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children Completed NCT02558933
30 Early Identification of Affected Children and Nutritional Risk Factors for FASD in Ukraine Completed NCT03782935
31 Self-Regulation in Adolescents With FASD: The Efficacy of a Targeted Intervention Completed NCT02912962
32 Modeling and Testing Change in Mental Abilities in Childhood Through Computer-based Interventions Completed NCT02459873
33 Effects of Hyperbaric Oxygen Therapy on Clinical Symptoms and Markers of Inflammation and Oxidative Stress in Autistic Children: A Pilot Study Completed NCT00324909 Hyperbaric Oxygen Therapy
34 Face Anthropometric Pattern Recognition Technology, Based on 3D Reconstruction Technology, for Computer Aided Diagnosis of Human Genetic Disorders. Multicenter Collaborative Study. Completed NCT00705055
35 Comprehensive Program for Youth Mental Health Completed NCT02169960
36 A Prospective, Randomized, Double-Blind, Controlled Study on the Clinical Effects of Hyperbaric Therapy in Autistic Children Completed NCT00335790
37 Augmented Biofeedback Training Combined With Physical Therapy Program Improves Visual-motor Integration, Visual Perception and Motor Coordination in Children With Spastic Hemiplegic Cerebral Palsy: a Randomized Control Trial Completed NCT03626077
38 Dissecting the Genetics of Fetal Alcohol Spectrum Disorders Recruiting NCT04072809
39 In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions Recruiting NCT03371641
40 The Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Life Span: Continuing Prevention and Longitudinal Epidemiology Recruiting NCT04026620
41 Parent Emotion Socialization and Child Emotion Regulation in FASD Recruiting NCT03524664
42 Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum Disorder Recruiting NCT03494738
43 Newborn Phosphatidylethanol Screening to Detect Fetal Alcohol Exposure in Uruguay Recruiting NCT02600624
44 Fetal Alcohol Spectrum Disorder-Is This a Ciliopathy? Recruiting NCT03802708
45 Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial Recruiting NCT03342495
46 Native-Changing High-risk Alcohol Use and Increasing Contraception Effectiveness Study Recruiting NCT03930342
47 The Effectiveness of an Educational Program on Parenting Stress and Coping Mechanism Among Parents of Children With Autism Spectrum Disorder in Amman, Jordan Recruiting NCT03805828
48 Food and Alcohol Behavior Study: Meaningful Enhancement Recruiting NCT04095052
49 Effectiveness of Visual and Auditory Feedback on Eye-hand Coordination in Children With Hemiplegic Cerebral Palsy Recruiting NCT03742999
50 Behavioral Exploration of Cognitive and Emotional Alterations in Adult Individuals Exposed to Alcohol During the Prenatal Period Active, not recruiting NCT03793920

Search NIH Clinical Center for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

Anatomical Context for Fetal Alcohol Syndrome

MalaCards organs/tissues related to Fetal Alcohol Syndrome:

40
Brain, T Cells, Bone, Eye, Thyroid, Kidney, Heart

Publications for Fetal Alcohol Syndrome

Articles related to Fetal Alcohol Syndrome:

(show top 50) (show all 3015)
# Title Authors PMID Year
1
Population-based prevalence of fetal alcohol spectrum disorder in Canada. 42
31253131 2019
2
Collaborative Action on Fetal Alcohol Spectrum Disorder Prevention: Principles for Enacting the Truth and Reconciliation Commission Call to Action #33. 42
31067652 2019
3
National Evaluation of Canadian Multi-Service FASD Prevention Programs: Interim Findings from the Co-Creating Evidence Study. 42
31109087 2019
4
Effect of gestational ethanol exposure on parvalbumin and calretinin expressing hippocampal neurons in a chick model of fetal alcohol syndrome. 54 61
19251116 2009
5
Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview. 54 61
17618743 2007
6
The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome. 54 61
7748347 1993
7
A hypothetical mechanism for fetal alcohol syndrome involving ethanol inhibition of retinoic acid synthesis at the alcohol dehydrogenase step. 54 61
1877746 1991
8
Developmental stage and genotype dependent behavioral effects of embryonic alcohol exposure in zebrafish larvae. 61
31655157 2020
9
Abortion is incommensurable with fetal alcohol syndrome. 61
31788809 2020
10
The impairment argument for the immorality of abortion revisited. 61
31788824 2020
11
Against the impairment argument: A reply to Hendricks. 61
32017158 2020
12
Family reflections: fetal alcohol spectrum disorders. 61
32028526 2020
13
The best possible start: A qualitative study on the experiences of parents of young children with or at risk for fetal alcohol spectrum disorders. 61
31884315 2020
14
Ophthalmological findings in fetal alcohol spectrum disorders - a cohort study from childhood to adulthood. 61
31926885 2020
15
Unisensory and Multisensory Responses in Fetal Alcohol Spectrum Disorders (FASD): Effects of Spatial Congruence. 61
31982473 2020
16
Hydrogen Sulfide Attenuates the Neurotoxicity in the Animal Model of Fetal Alcohol Spectrum Disorders. 61
31900896 2020
17
Neurodevelopmental Outcomes Associated with Prefrontal Cortical Deoxygenation in Children with Fetal Alcohol Spectrum Disorders. 61
31914808 2020
18
The protective effect of quercetin in the alcohol-induced liver and lymphoid tissue injuries in newborns. 61
31673888 2020
19
Prenatal Alcohol Exposure Alters Error Detection During Simple Arithmetic Processing: An Electroencephalography Study. 61
31742737 2020
20
Fetal Alcohol Spectrum Disorders: Health Needs Assessment in Brazil. 61
31984499 2020
21
Self-care in caregivers of children with FASD: How do caregivers care for themselves, and what are the benefits and obstacles for doing so? 61
32014800 2020
22
Neurodevelopment in adolescents and adults with fetal alcohol spectrum disorders (FASD): A magnetic resonance region of interest analysis. 61
31930998 2020
23
Novel Ethanol-Sensitive Mutants Identified in an F3 Forward Genetic Screen. 61
31742718 2020
24
Prenatal Ethanol Exposure Leads to Attention Deficits in Both Male and Female Rats. 61
32038156 2020
25
The Impact of Paternal Alcohol Consumption on Offspring Brain and Behavioral Development. 61
31746471 2020
26
Association of adverse childhood experiences and neurodevelopmental disorders in people with fetal alcohol spectrum disorders (FASD) and non-FASD controls. 61
31842817 2019
27
Comparing Executive Functioning in Children and Adolescents With Fetal Alcohol Spectrum Disorders and ADHD: A Meta-Analysis. 61
26729621 2019
28
Alcohol use, pregnancy and associated risk factors: a pilot cross-sectional study of pregnant women attending prenatal care in an urban city. 61
31805891 2019
29
Radiological Findings on Structural Magnetic Resonance Imaging in Fetal Alcohol Spectrum Disorders and Healthy Controls. 61
31840819 2019
30
Children with Fetal Alcohol Syndrome (FAS): 3D-Analysis of Palatal Depth and 3D-Metric Facial Length. 61
31877770 2019
31
The Subplate: A Potential Driver of Cortical Folding? 61
30721930 2019
32
Episodic Prenatal Exposure To Ethanol Affects Postnatal Neurogenesis In The Macaque Dentate Gyrus And Visual Recognition Memory. 61
31706015 2019
33
Fetal Alcohol Spectrum Disorders in a Pacific Southwest City: Maternal and Child Characteristics. 61
31688971 2019
34
Two case reports of fetal alcohol syndrome: broadening into the spectrum of cardiac disease to personalize and to improve clinical assessment. 61
31856879 2019
35
Spatial Navigation in Children and Young Adults with Fetal Alcohol Spectrum Disorders. 61
31593324 2019
36
Early Detection of Fetal Alcohol Spectrum Disorders: An Elusive but Critical Goal. 61
31744892 2019
37
Ocular fetal alcohol spectrum disorders. 61
31879141 2019
38
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. 61
31744890 2019
39
Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood. 61
31872887 2019
40
Morphological changes of the dorsal contour of the corpus callosum during the first two years of life. 61
31840188 2019
41
Maternal adverse childhood experiences are associated with binge drinking during pregnancy in a dose-dependent pattern: Findings from the All Our Families cohort. 61
31896532 2019
42
Modification of stem cell states by alcohol and acetaldehyde. 61
31846616 2019
43
Proceedings of the 2018 annual meeting of the Fetal Alcohol Spectrum Disorders study group. 61
31173861 2019
44
Programmed increases in LXRα induced by paternal alcohol use enhance offspring metabolic adaptation to high-fat diet induced obesity. 61
31767168 2019
45
Tooth Malformations, DMFT Index, Speech Impairment and Oral Habits in Patients with Fetal Alcohol Syndrome. 61
31717945 2019
46
Mental health outcomes among parents of a child who has a developmental disability: Comparing different types of developmental disability. 61
31796336 2019
47
[Fetal alcohol exposure: when placenta would help to the early diagnosis of child brain impairments]. 61
31845877 2019
48
Animal models of gene-alcohol interactions. 61
31774246 2019
49
Prenatal and postnatal alcohol exposure increases vulnerability to cocaine addiction in adult mice. 61
31705540 2019
50
Fetal alcohol spectrum disorders from childhood to adulthood: a Swedish population-based naturalistic cohort study of adoptees from Eastern Europe. 61
31666274 2019

Variations for Fetal Alcohol Syndrome

Expression for Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for Fetal Alcohol Syndrome

Pathways related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.12 ALDH2 ADH7 ADH1B ADH1A
2
Show member pathways
11.93 ALDH2 AKR1A1 ADH7 ADH1B ADH1A
3
Show member pathways
11.36 ALDH2 AKR1A1 ADH1B
4
Show member pathways
11.21 ADH7 ADH1B ADH1A
5
Show member pathways
10.61 ALDH2 ADH1B
6
Show member pathways
10.58 ALDH2 ADH1B
7
Show member pathways
10.51 ALDH2 AKR1A1 ADH7 ADH1B ADH1A
8 10.44 ADH1B ADH1A

GO Terms for Fetal Alcohol Syndrome

Cellular components related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.35 KCNJ2 CHRM3 CALB2 BDNF ADNP
2 cuticular plate GO:0032437 8.62 PVALB CALB2

Biological processes related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.5 SLC27A5 KDM4C ALDH2 AKR1A1 ADH7 ADH1B
2 retinol metabolic process GO:0042572 9.43 ADH7 ADH1B ADH1A
3 ethanol catabolic process GO:0006068 9.37 ALDH2 ADH7
4 retinoic acid metabolic process GO:0042573 9.33 ADH7 ADH1B ADH1A
5 alcohol metabolic process GO:0006066 9.32 ALDH2 ADH1A
6 ethanol oxidation GO:0006069 8.92 ALDH2 ADH7 ADH1B ADH1A

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.7 SLC27A5 KDM4C ALDH2 AKR1A1 ADH7 ADH1B
2 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.13 ADH7 ADH1B ADH1A
3 retinol dehydrogenase activity GO:0004745 8.92 AKR1A1 ADH7 ADH1B ADH1A

Sources for Fetal Alcohol Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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