MCID: FTL012
MIFTS: 33

Fetal and Neonatal Alloimmune Thrombocytopenia

Categories: Rare diseases, Blood diseases, Fetal diseases

Aliases & Classifications for Fetal and Neonatal Alloimmune Thrombocytopenia

MalaCards integrated aliases for Fetal and Neonatal Alloimmune Thrombocytopenia:

Name: Fetal and Neonatal Alloimmune Thrombocytopenia 53 59 6
Nait 53 59
Neonatal Alloimmune Thrombocytopenia 73

Classifications:



External Ids:

Orphanet 59 ORPHA853
ICD10 via Orphanet 34 P61.0
UMLS via Orphanet 74 C3854603 C3853779
UMLS 73 C3853779

Summaries for Fetal and Neonatal Alloimmune Thrombocytopenia

NIH Rare Diseases : 53 Fetal and neonatal alloimmune thrombocytopenia (NAIT) is a blood disorder that affects pregnant women and their babies. NAIT was first reported in the literature in 1953 and is estimated to occur in as many as 1 in 1200 live births. NAIT results in the destruction of platelets in the fetus or infant due to a mismatch between the mother’s platelets and those of the baby. Certain molecules (antigens) on the surface of the baby's platelets are recognized as foreign by the mother's immune system. The mother’s immune system then creates antibodies that attack and destroy the baby’s platelets. Though NAIT can occur whenever the mother’s blood mixes with that of the baby, it is usually triggered when the mother is exposed to the baby’s blood during delivery. Many cases of NAIT are mild. Signs and symptoms may include a low platelet count (thrombocytopenia) and signs of bleeding into the skin such as petechiae and purpura. In the most severe cases, NAIT can cause bleeding episodes that may result in death or long-term disability. Bleeding episodes can occur either during pregnancy or after birth. Management of the infant with neonatal alloimmune thrombocytopenia may include platelet transfusions, ultrasounds, and intravenous immunoglobulin (IVIG). Treatment for pregnant mothers at risk for NAIT may include IVIG and steroids. 

MalaCards based summary : Fetal and Neonatal Alloimmune Thrombocytopenia, also known as nait, is related to thrombocytopenia and bleeding disorder, platelet-type, 16. An important gene associated with Fetal and Neonatal Alloimmune Thrombocytopenia is ITGB3 (Integrin Subunit Beta 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Actin Nucleation by ARP-WASP Complex. Affiliated tissues include skin.

Related Diseases for Fetal and Neonatal Alloimmune Thrombocytopenia

Graphical network of the top 20 diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia:



Diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia

Symptoms & Phenotypes for Fetal and Neonatal Alloimmune Thrombocytopenia

Drugs & Therapeutics for Fetal and Neonatal Alloimmune Thrombocytopenia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Kinetics of Blood Platelets Transfused to Healthy Subjects Recruiting NCT03561909 Not Applicable

Search NIH Clinical Center for Fetal and Neonatal Alloimmune Thrombocytopenia

Genetic Tests for Fetal and Neonatal Alloimmune Thrombocytopenia

Anatomical Context for Fetal and Neonatal Alloimmune Thrombocytopenia

MalaCards organs/tissues related to Fetal and Neonatal Alloimmune Thrombocytopenia:

41
Skin

Publications for Fetal and Neonatal Alloimmune Thrombocytopenia

Articles related to Fetal and Neonatal Alloimmune Thrombocytopenia:

(show all 36)
# Title Authors Year
1
Intracranial hemorrhages in neonates born from 32 weeks of gestation-low frequency of associated fetal and neonatal alloimmune thrombocytopenia: a register-based study. ( 29119564 )
2018
2
Adding to the complexity of fetal and neonatal alloimmune thrombocytopenia: Reduced fibrinogen binding in the presence of anti-HPA-1a antibody and hypo-responsive neonatal platelets. ( 29306729 )
2018
3
Perinatal Outcome and Long-Term Neurodevelopment after Intracranial Haemorrhage due to Fetal and Neonatal Alloimmune Thrombocytopenia. ( 29730660 )
2018
4
Screening for fetal and neonatal alloimmune thrombocytopenia - lessons learned from a Norwegian screening program. ( 29412452 )
2018
5
Fetal and neonatal alloimmune thrombocytopenia: evidence based antenatal and postnatal management strategies. ( 28644735 )
2017
6
Current perspectives on fetal and neonatal alloimmune thrombocytopenia - increasing clinical concerns and new treatment opportunities. ( 28458583 )
2017
7
Antenatal management in fetal and neonatal alloimmune thrombocytopenia: a systematic review. ( 28130210 )
2017
8
Maternal HLA genotyping is not useful for predicting severity of fetal and neonatal alloimmune thrombocytopenia. ( 27748520 )
2017
9
Fetal and neonatal alloimmune thrombocytopenia. ( 26810319 )
2016
10
Fetal and neonatal alloimmune thrombocytopenia: predictive factors of intracranial hemorrhage. ( 26469867 )
2016
11
Fetal and Neonatal Alloimmune Thrombocytopenia: Management and Outcome of a Large International Retrospective Cohort. ( 27728915 )
2016
12
Lower-dose intravenous immunoglobulins for the treatment of fetal and neonatal alloimmune thrombocytopenia: a cohort study. ( 27383293 )
2016
13
Blood group A mothers are more likely to develop anemia during antenatal intravenous immunoglobulin treatment of fetal and neonatal alloimmune thrombocytopenia. ( 27611703 )
2016
14
HLA-DRB3*01:01 is a predictor of immunization against human platelet antigen-1a but not of the severity of fetal and neonatal alloimmune thrombocytopenia. ( 28019029 )
2016
15
Anti-Human Platelet Antigen-1a Immunoglobulin G Preparation Intended to Prevent Fetal and Neonatal Alloimmune Thrombocytopenia. ( 27627660 )
2016
16
What do we know about intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia? ( 26756707 )
2016
17
Placental histological lesions in fetal and neonatal alloimmune thrombocytopenia: A retrospective cohort study of 21 cases. ( 27871460 )
2016
18
Alloantibody against new platelet alloantigen (Lap(a)) on glycoprotein IIb is responsible for a case of fetal and neonatal alloimmune thrombocytopenia. ( 26388194 )
2015
19
Low-Dose versus Standard-Dose Intravenous Immunoglobulin to Prevent Fetal Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia: A Randomized Trial. ( 25896635 )
2015
20
Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia. ( 28345015 )
2015
21
Recent progress in understanding the pathogenesis of fetal and neonatal alloimmune thrombocytopenia. ( 26344048 )
2015
22
How do we treat fetal and neonatal alloimmune thrombocytopenia? ( 24773309 )
2014
23
Co-stimulation with LPS or Poly I:C markedly enhances the anti-platelet immune response and severity of fetal and neonatal alloimmune thrombocytopenia. ( 24067944 )
2013
24
Fetal and neonatal alloimmune thrombocytopenia. ( 23687553 )
2013
25
Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry. ( 23524102 )
2013
26
The implementation of surface plasmon resonance technique in monitoring pregnancies with expected fetal and neonatal alloimmune thrombocytopenia. ( 23278334 )
2013
27
Maternal hemolysis after intravenous immunoglobulin treatment in fetal and neonatal alloimmune thrombocytopenia. ( 23344412 )
2013
28
Would it be possible to prevent HPA-1a alloimmunization to reduce the incidence of fetal and neonatal alloimmune thrombocytopenia? ( 22780891 )
2012
29
A review of the contemporary management of fetal and neonatal alloimmune thrombocytopenia in an Australian tertiary obstetric hospital. ( 22510050 )
2012
30
Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody-mediated immune suppression and prevention of severe clinical complications in a murine model. ( 22251227 )
2012
31
Fetal and neonatal alloimmune thrombocytopenia. ( 23482913 )
2012
32
Delayed diagnosis of fetal and neonatal alloimmune thrombocytopenia: a cause of perinatal mortality and morbidity. ( 23078538 )
2012
33
Fetal and neonatal alloimmune thrombocytopenia: a management algorithm based on risk stratification. ( 22015886 )
2011
34
Fetal and neonatal alloimmune thrombocytopenia: prenatal interventions. ( 21618560 )
2011
35
The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia. ( 21708486 )
2011
36
A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. ( 16317099 )
2006

Variations for Fetal and Neonatal Alloimmune Thrombocytopenia

ClinVar genetic disease variations for Fetal and Neonatal Alloimmune Thrombocytopenia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ITGB3 NM_000212.2(ITGB3): c.1373A> G (p.Asp458Gly) single nucleotide variant association GRCh38 Chromosome 17, 47292251: 47292251
2 ITGB3 NM_000212.2(ITGB3): c.1373A> G (p.Asp458Gly) single nucleotide variant association GRCh37 Chromosome 17, 45369617: 45369617

Expression for Fetal and Neonatal Alloimmune Thrombocytopenia

Search GEO for disease gene expression data for Fetal and Neonatal Alloimmune Thrombocytopenia.

Pathways for Fetal and Neonatal Alloimmune Thrombocytopenia

Pathways related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 CD109 GP1BA GP1BB ITGA2 ITGA2B ITGB3
2
Show member pathways
12.66 HLA-DRB3 ITGA2 ITGA2B ITGB3
3
Show member pathways
12.55 ITGA2 ITGA2B ITGB3
4
Show member pathways
12.52 ITGA2 ITGA2B ITGB3
5
Show member pathways
12.47 ITGA2 ITGA2B ITGB3
6 12.37 ITGA2 ITGA2B ITGB3
7
Show member pathways
12.18 ITGA2 ITGA2B ITGB3
8
Show member pathways
11.97 ITGA2 ITGA2B ITGB3
9 11.92 ITGA2 ITGA2B ITGB3
10 11.91 HLA-DRB3 ITGA2 ITGB3
11
Show member pathways
11.78 ITGA2 ITGA2B ITGB3
12 11.77 GP1BA ITGA2 ITGA2B ITGB3
13
Show member pathways
11.73 GP1BA GP1BB ITGA2 ITGA2B ITGB3
14
Show member pathways
11.66 GP1BA GP1BB ITGA2B ITGB3
15 11.62 ITGA2 ITGA2B
16 11.58 ITGA2 ITGA2B ITGB3
17
Show member pathways
11.46 ITGA2 ITGB3
18 11.44 GP1BA GP1BB ITGA2 ITGA2B ITGB3
19 11.39 ITGA2 ITGA2B ITGB3
20 11.39 ITGA2 ITGA2B ITGB3
21 11.33 ITGA2B ITGB3
22 11.3 ITGA2B ITGB3
23 11.3 ITGA2 ITGA2B ITGB3
24 11.27 GP1BB ITGA2 ITGA2B ITGB3
25 11.22 ITGA2 ITGB3
26 11.17 ITGA2 ITGA2B
27 11.14 ITGA2B ITGB3
28 11.09 GP1BA GP1BB HLA-DRB3 ITGA2 ITGA2B ITGB3
29 11.02 ITGA2B ITGB3
30 10.89 ITGA2B ITGB3
31 10.61 GP1BA GP1BB ITGA2
32 10.49 GP1BA GP1BB

GO Terms for Fetal and Neonatal Alloimmune Thrombocytopenia

Cellular components related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.91 CD109 GP1BA GP1BB HLA-DRB3 ITGA2 ITGA2B
2 plasma membrane GO:0005886 9.8 CD109 GP1BA GP1BB HLA-DRB3 ITGA2 ITGA2B
3 cell surface GO:0009986 9.55 CD109 GP1BA ITGA2 ITGA2B ITGB3
4 focal adhesion GO:0005925 9.5 ITGA2 ITGA2B ITGB3
5 integrin complex GO:0008305 9.13 ITGA2 ITGA2B ITGB3
6 platelet alpha granule membrane GO:0031092 8.8 CD109 ITGA2B ITGB3

Biological processes related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.7 ITGA2 ITGA2B ITGB3
2 platelet degranulation GO:0002576 9.58 CD109 ITGA2B ITGB3
3 wound healing GO:0042060 9.57 ITGA2 ITGB3
4 viral entry into host cell GO:0046718 9.56 ITGA2 ITGB3
5 regulation of megakaryocyte differentiation GO:0045652 9.55 GP1BA ITGA2B
6 cell adhesion GO:0007155 9.55 GP1BA GP1BB ITGA2 ITGA2B ITGB3
7 hemostasis GO:0007599 9.54 GP1BA GP1BB
8 platelet activation GO:0030168 9.54 GP1BA GP1BB ITGB3
9 blood coagulation, intrinsic pathway GO:0007597 9.51 GP1BA GP1BB
10 cell-matrix adhesion GO:0007160 9.5 ITGA2 ITGA2B ITGB3
11 cell-substrate adhesion GO:0031589 9.49 ITGA2 ITGB3
12 cell adhesion mediated by integrin GO:0033627 9.48 ITGA2 ITGB3
13 positive regulation of leukocyte migration GO:0002687 9.46 ITGA2 ITGA2B
14 mesodermal cell differentiation GO:0048333 9.43 ITGA2 ITGB3
15 integrin-mediated signaling pathway GO:0007229 9.43 ITGA2 ITGA2B ITGB3
16 platelet aggregation GO:0070527 9.13 GP1BA ITGA2B ITGB3
17 blood coagulation GO:0007596 8.92 GP1BA GP1BB ITGA2 ITGB3

Molecular functions related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.96 ITGA2 ITGB3
2 extracellular matrix binding GO:0050840 8.62 ITGA2B ITGB3

Sources for Fetal and Neonatal Alloimmune Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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