MCID: FTL012
MIFTS: 39

Fetal and Neonatal Alloimmune Thrombocytopenia

Categories: Blood diseases, Fetal diseases, Immune diseases, Rare diseases

Aliases & Classifications for Fetal and Neonatal Alloimmune Thrombocytopenia

MalaCards integrated aliases for Fetal and Neonatal Alloimmune Thrombocytopenia:

Name: Fetal and Neonatal Alloimmune Thrombocytopenia 54 60 6
Nait 54 60
Neonatal Alloimmune Thrombocytopenia 74
Fnait 60

Classifications:



External Ids:

ICD10 via Orphanet 35 P61.0
UMLS via Orphanet 75 C3853779 C3854603
Orphanet 60 ORPHA853
UMLS 74 C3853779

Summaries for Fetal and Neonatal Alloimmune Thrombocytopenia

NIH Rare Diseases : 54 Fetal and neonatal alloimmune thrombocytopenia (NAIT) is a blood disorder that affects pregnant women and their babies. NAIT was first reported in the literature in 1953 and is estimated to occur in as many as 1 in 1200 live births. NAIT results in the destruction of platelets in the fetus or infant due to a mismatch between the mother�??s platelets and those of the baby. Certain molecules (antigens) on the surface of the baby's platelets are recognized as foreign by the mother's immune system. The mother�??s immune system then creates antibodies that attack and destroy the baby�??s platelets. Though NAIT can occur whenever the mother�??s blood mixes with that of the baby, it is usually triggered when the mother is exposed to the baby�??s blood during delivery. Many cases of NAIT are mild. Signs and symptoms may include a low platelet count (thrombocytopenia) and signs of bleeding into the skin such as petechiae and purpura. In the most severe cases, NAIT can cause bleeding episodes that may result in death or long-term disability. Bleeding episodes can occur either during pregnancy or after birth. Management of the infant with neonatal alloimmune thrombocytopenia may include platelet transfusions, ultrasounds, and intravenous immunoglobulin (IVIG). Treatment for pregnant mothers at risk for NAIT may include IVIG and steroids. 

MalaCards based summary : Fetal and Neonatal Alloimmune Thrombocytopenia, also known as nait, is related to thrombocytopenia and thrombocytopenia due to platelet alloimmunization. An important gene associated with Fetal and Neonatal Alloimmune Thrombocytopenia is ITGB3 (Integrin Subunit Beta 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Actin Nucleation by ARP-WASP Complex. The drugs Immunoglobulins, Intravenous and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin and brain.

Wikipedia : 77 Neonatal alloimmune thrombocytopenia (NAITP, NAIT, NATP or NAT) is a disease that affects babies in... more...

Related Diseases for Fetal and Neonatal Alloimmune Thrombocytopenia

Diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenia 30.0 GP1BA GP1BB ITGA2 ITGA2B ITGB3
2 thrombocytopenia due to platelet alloimmunization 29.8 ITGA2 ITGA2B ITGB3
3 laryngeal adductor paralysis 10.1
4 neutropenia 10.1
5 aspirin resistance 10.1 ITGA2 ITGB3
6 myeloproliferative syndrome, transient 10.0 GP1BA ITGB3
7 coronary thrombosis 10.0 GP1BA ITGB3
8 bleeding disorder, platelet-type, 16 10.0 ITGA2B ITGB3
9 arteritic anterior ischemic optic neuropathy 10.0 GP1BA ITGB3
10 ischemic optic neuropathy 10.0 GP1BA ITGB3
11 infective endocarditis 9.9 GP1BA ITGB3
12 pseudo-von willebrand disease 9.8 GP1BA GP1BB
13 thrombocytopenic purpura, autoimmune 9.7 GP1BA ITGA2B ITGB3
14 hemorrhagic disease 9.7 GP1BA ITGA2B
15 essential thrombocythemia 9.7 GP1BA ITGA2B ITGB3
16 purpura 9.6 GP1BB ITGA2B ITGB3
17 velocardiofacial syndrome 9.5 GP1BA GP1BB
18 primary thrombocytopenia 9.5 GP1BA ITGA2 ITGA2B ITGB3
19 autoimmune disease of blood 9.5 GP1BA ITGA2 ITGA2B ITGB3
20 von willebrand disease, type 2 9.5 GP1BA ITGA2 ITGA2B ITGB3
21 thrombasthenia 9.5 GP1BA ITGA2 ITGA2B ITGB3
22 glanzmann thrombasthenia 9.5 GP1BA ITGA2 ITGA2B ITGB3
23 myocardial infarction 9.4 GP1BA ITGA2 ITGA2B ITGB3
24 autosomal dominant macrothrombocytopenia 9.3 GP1BA GP1BB ITGA2B ITGB3
25 inherited blood coagulation disease 9.3 GP1BA GP1BB ITGA2B ITGB3
26 blood coagulation disease 9.3 GP1BA GP1BB ITGA2B ITGB3
27 blood platelet disease 9.3 GP1BA GP1BB ITGA2B ITGB3
28 bernard-soulier syndrome 9.0 GP1BA GP1BB ITGA2 ITGA2B ITGB3

Graphical network of the top 20 diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia:



Diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia

Symptoms & Phenotypes for Fetal and Neonatal Alloimmune Thrombocytopenia

Drugs & Therapeutics for Fetal and Neonatal Alloimmune Thrombocytopenia

Drugs for Fetal and Neonatal Alloimmune Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins, Intravenous
2 Immunologic Factors
3 Rho(D) Immune Globulin
4 Immunoglobulins
5 gamma-Globulins
6 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Genotyping of Human Platelet Alloantigens : Non-invasive Prenatal Diagnosis Unknown status NCT02899598 Not Applicable
2 Kinetics of Blood Platelets Transfused to Healthy Subjects Completed NCT03561909 Not Applicable
3 Monitoring Outcome in Neonatal Thrombocytopenia Completed NCT03110887
4 Maternal High Blood Pressure and Newborn's Blood Profile Completed NCT03265704
5 Immune Thrombocytopenia in Pregnancy Recruiting NCT02892630
6 Mathematical Modeling to Predict the Duration of Thrombocytopenia in Neonates Active, not recruiting NCT02802982
7 Study on the Anti-HPA Antibodies Caused Neonatal Alloimmune Thrombocytopenia in Chinese Pregnant Women Not yet recruiting NCT02934906
8 Neonatal Thrombocytopenia Among Newborns Admitted to Neonatal Intensive Care Unit Not yet recruiting NCT03448952
9 Impact of Thrombocytopenia and Platelet Transfusions on Neonatal Bleeding and Inflammation Not yet recruiting NCT03848923

Search NIH Clinical Center for Fetal and Neonatal Alloimmune Thrombocytopenia

Genetic Tests for Fetal and Neonatal Alloimmune Thrombocytopenia

Anatomical Context for Fetal and Neonatal Alloimmune Thrombocytopenia

MalaCards organs/tissues related to Fetal and Neonatal Alloimmune Thrombocytopenia:

42
Skin, Brain

Publications for Fetal and Neonatal Alloimmune Thrombocytopenia

Articles related to Fetal and Neonatal Alloimmune Thrombocytopenia:

(show top 50) (show all 62)
# Title Authors Year
1
Perinatal Outcome and Long-Term Neurodevelopment after Intracranial Haemorrhage due to Fetal and Neonatal Alloimmune Thrombocytopenia. ( 29730660 )
2019
2
Fetal and neonatal alloimmune thrombocytopenia: recommendations for evidence-based practice, an international approach. ( 30828796 )
2019
3
Intracranial hemorrhages in neonates born from 32 weeks of gestation-low frequency of associated fetal and neonatal alloimmune thrombocytopenia: a register-based study. ( 29119564 )
2018
4
Adding to the complexity of fetal and neonatal alloimmune thrombocytopenia: Reduced fibrinogen binding in the presence of anti-HPA-1a antibody and hypo-responsive neonatal platelets. ( 29306729 )
2018
5
Screening for fetal and neonatal alloimmune thrombocytopenia - lessons learned from a Norwegian screening program. ( 29412452 )
2018
6
Implication of antibodies against human leukocyte antigen in simultaneous presentation of fetal and neonatal alloimmune thrombocytopenia and neutropenia. ( 30318177 )
2018
7
Investigations for fetal and neonatal alloimmune thrombocytopenia: communication from the SSC of the ISTH. ( 30382606 )
2018
8
Fetal and neonatal alloimmune thrombocytopenia. ( 30848151 )
2018
9
Fetal and Neonatal Alloimmune Thrombocytopenia: Management and Outcome of a Large International Retrospective Cohort. ( 27728915 )
2017
10
Maternal HLA genotyping is not useful for predicting severity of fetal and neonatal alloimmune thrombocytopenia. ( 27748520 )
2017
11
HLA-DRB3*01:01 is a predictor of immunization against human platelet antigen-1a but not of the severity of fetal and neonatal alloimmune thrombocytopenia. ( 28019029 )
2017
12
Antenatal management in fetal and neonatal alloimmune thrombocytopenia: a systematic review. ( 28130210 )
2017
13
Current perspectives on fetal and neonatal alloimmune thrombocytopenia - increasing clinical concerns and new treatment opportunities. ( 28458583 )
2017
14
Fetal and neonatal alloimmune thrombocytopenia: evidence based antenatal and postnatal management strategies. ( 28644735 )
2017
15
Fetal and neonatal alloimmune thrombocytopenia: predictive factors of intracranial hemorrhage. ( 26469867 )
2016
16
What do we know about intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia? ( 26756707 )
2016
17
Fetal and neonatal alloimmune thrombocytopenia. ( 26810319 )
2016
18
Lower-dose intravenous immunoglobulins for the treatment of fetal and neonatal alloimmune thrombocytopenia: a cohort study. ( 27383293 )
2016
19
Blood group A mothers are more likely to develop anemia during antenatal intravenous immunoglobulin treatment of fetal and neonatal alloimmune thrombocytopenia. ( 27611703 )
2016
20
Anti-Human Platelet Antigen-1a Immunoglobulin G Preparation Intended to Prevent Fetal and Neonatal Alloimmune Thrombocytopenia. ( 27627660 )
2016
21
Placental histological lesions in fetal and neonatal alloimmune thrombocytopenia: A retrospective cohort study of 21 cases. ( 27871460 )
2016
22
Low-Dose versus Standard-Dose Intravenous Immunoglobulin to Prevent Fetal Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia: A Randomized Trial. ( 25896635 )
2015
23
Recent progress in understanding the pathogenesis of fetal and neonatal alloimmune thrombocytopenia. ( 26344048 )
2015
24
Alloantibody against new platelet alloantigen (Lap(a)) on glycoprotein IIb is responsible for a case of fetal and neonatal alloimmune thrombocytopenia. ( 26388194 )
2015
25
Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia. ( 28345015 )
2015
26
How do we treat fetal and neonatal alloimmune thrombocytopenia? ( 24773309 )
2014
27
Core fucosylation and IgG function in NAIT. ( 24458274 )
2014
28
The implementation of surface plasmon resonance technique in monitoring pregnancies with expected fetal and neonatal alloimmune thrombocytopenia. ( 23278334 )
2013
29
Maternal hemolysis after intravenous immunoglobulin treatment in fetal and neonatal alloimmune thrombocytopenia. ( 23344412 )
2013
30
Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry. ( 23524102 )
2013
31
Fetal and neonatal alloimmune thrombocytopenia. ( 23687553 )
2013
32
Co-stimulation with LPS or Poly I:C markedly enhances the anti-platelet immune response and severity of fetal and neonatal alloimmune thrombocytopenia. ( 24067944 )
2013
33
Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody-mediated immune suppression and prevention of severe clinical complications in a murine model. ( 22251227 )
2012
34
A review of the contemporary management of fetal and neonatal alloimmune thrombocytopenia in an Australian tertiary obstetric hospital. ( 22510050 )
2012
35
Would it be possible to prevent HPA-1a alloimmunization to reduce the incidence of fetal and neonatal alloimmune thrombocytopenia? ( 22780891 )
2012
36
Delayed diagnosis of fetal and neonatal alloimmune thrombocytopenia: a cause of perinatal mortality and morbidity. ( 23078538 )
2012
37
Fetal and neonatal alloimmune thrombocytopenia. ( 23482913 )
2012
38
Fetal and neonatal alloimmune thrombocytopenia: harvesting the evidence to develop a clinical approach to management. ( 20700860 )
2011
39
A new platelet alloantigen, Swi(a) , located on glycoprotein Ia identified in a family with fetal and neonatal alloimmune thrombocytopenia. ( 21332723 )
2011
40
Fetal and neonatal alloimmune thrombocytopenia: prenatal interventions. ( 21618560 )
2011
41
The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia. ( 21708486 )
2011
42
Fetal and neonatal alloimmune thrombocytopenia: a management algorithm based on risk stratification. ( 22015886 )
2011
43
A review of pathophysiology and current treatment for neonatal alloimmune thrombocytopenia (NAIT) and introducing the Australian NAIT registry. ( 21631435 )
2011
44
Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention. ( 21083473 )
2010
45
Fetal and neonatal alloimmune thrombocytopenia. ( 17936686 )
2008
46
Fetal and neonatal alloimmune thrombocytopenia: progress and ongoing debates. ( 17981381 )
2008
47
Direct comparison between two quantitative assays in the measurement of maternal anti-HPA-1a antibody in neonatal alloimmune thrombocytopenia (NAIT). ( 18945639 )
2008
48
Noninvasive antenatal management of fetal and neonatal alloimmune thrombocytopenia: safe and effective. ( 17309545 )
2007
49
Postnatal management of fetal and neonatal alloimmune thrombocytopenia: the role of matched platelet transfusion and IVIG. ( 17177068 )
2007
50
A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. ( 16317099 )
2006

Variations for Fetal and Neonatal Alloimmune Thrombocytopenia

ClinVar genetic disease variations for Fetal and Neonatal Alloimmune Thrombocytopenia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ITGB3 NM_000212.2(ITGB3): c.1373A> G (p.Asp458Gly) single nucleotide variant association rs1555572829 GRCh38 Chromosome 17, 47292251: 47292251
2 ITGB3 NM_000212.2(ITGB3): c.1373A> G (p.Asp458Gly) single nucleotide variant association rs1555572829 GRCh37 Chromosome 17, 45369617: 45369617

Expression for Fetal and Neonatal Alloimmune Thrombocytopenia

Search GEO for disease gene expression data for Fetal and Neonatal Alloimmune Thrombocytopenia.

Pathways for Fetal and Neonatal Alloimmune Thrombocytopenia

Pathways related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 CD109 GP1BA GP1BB ITGA2 ITGA2B ITGB3
2
Show member pathways
12.73 HLA-DRB3 ITGA2 ITGA2B ITGB3
3
Show member pathways
12.55 ITGA2 ITGA2B ITGB3
4
Show member pathways
12.54 ITGA2 ITGA2B ITGB3
5
Show member pathways
12.49 ITGA2 ITGA2B ITGB3
6 12.39 ITGA2 ITGA2B ITGB3
7
Show member pathways
12.19 ITGA2 ITGA2B ITGB3
8
Show member pathways
12.13 ITGA2 ITGA2B ITGB3
9
Show member pathways
11.98 ITGA2 ITGA2B ITGB3
10
Show member pathways
11.97 ITGA2 ITGA2B ITGB3
11 11.91 HLA-DRB3 ITGA2 ITGB3
12 11.9 ITGA2 ITGA2B ITGB3
13
Show member pathways
11.78 ITGA2 ITGA2B ITGB3
14 11.77 GP1BA ITGA2 ITGA2B ITGB3
15
Show member pathways
11.74 GP1BA GP1BB ITGA2 ITGA2B ITGB3
16 11.7 ITGA2 ITGA2B ITGB3
17
Show member pathways
11.66 GP1BA GP1BB ITGA2B ITGB3
18 11.64 ITGA2 ITGA2B
19 11.58 ITGA2 ITGA2B ITGB3
20 11.5 ITGA2 ITGA2B ITGB3
21 11.45 GP1BA GP1BB ITGA2 ITGA2B ITGB3
22 11.39 ITGA2 ITGA2B ITGB3
23 11.39 ITGA2 ITGA2B ITGB3
24 11.35 ITGA2B ITGB3
25 11.32 ITGA2B ITGB3
26 11.3 ITGA2 ITGA2B ITGB3
27 11.27 GP1BB ITGA2 ITGA2B ITGB3
28 11.23 ITGA2 ITGB3
29 11.18 ITGA2 ITGA2B
30 11.17 ITGA2 ITGA2B ITGB3
31 11.15 ITGA2B ITGB3
32 11.09 GP1BA GP1BB HLA-DRB3 ITGA2 ITGA2B ITGB3
33 11.03 ITGA2B ITGB3
34 10.91 ITGA2B ITGB3
35 10.61 GP1BA GP1BB ITGA2
36 10.49 GP1BA GP1BB

GO Terms for Fetal and Neonatal Alloimmune Thrombocytopenia

Cellular components related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.95 CD109 GP1BA GP1BB HLA-DRB3 ITGA2 ITGA2B
2 plasma membrane GO:0005886 9.8 CD109 GP1BA GP1BB HLA-DRB3 ITGA2 ITGA2B
3 integral component of plasma membrane GO:0005887 9.67 GP1BA GP1BB HLA-DRB3 ITGB3
4 cell surface GO:0009986 9.55 CD109 GP1BA ITGA2 ITGA2B ITGB3
5 focal adhesion GO:0005925 9.5 ITGA2 ITGA2B ITGB3
6 integrin complex GO:0008305 9.13 ITGA2 ITGA2B ITGB3
7 platelet alpha granule membrane GO:0031092 8.8 CD109 ITGA2B ITGB3

Biological processes related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.7 ITGA2 ITGA2B ITGB3
2 platelet degranulation GO:0002576 9.58 CD109 ITGA2B ITGB3
3 wound healing GO:0042060 9.57 ITGA2 ITGB3
4 viral entry into host cell GO:0046718 9.56 ITGA2 ITGB3
5 regulation of megakaryocyte differentiation GO:0045652 9.55 GP1BA ITGA2B
6 hemostasis GO:0007599 9.54 GP1BA GP1BB
7 platelet activation GO:0030168 9.54 GP1BA GP1BB ITGB3
8 cell adhesion mediated by integrin GO:0033627 9.51 ITGA2 ITGB3
9 cell-matrix adhesion GO:0007160 9.5 ITGA2 ITGA2B ITGB3
10 cell-substrate adhesion GO:0031589 9.49 ITGA2 ITGB3
11 blood coagulation, intrinsic pathway GO:0007597 9.48 GP1BA GP1BB
12 mesodermal cell differentiation GO:0048333 9.46 ITGA2 ITGB3
13 positive regulation of leukocyte migration GO:0002687 9.43 ITGA2 ITGA2B
14 integrin-mediated signaling pathway GO:0007229 9.43 ITGA2 ITGA2B ITGB3
15 cell adhesion GO:0007155 9.35 GP1BA GP1BB ITGA2 ITGA2B ITGB3
16 platelet aggregation GO:0070527 9.33 GP1BA ITGA2B ITGB3
17 blood coagulation GO:0007596 8.92 GP1BA GP1BB ITGA2 ITGB3

Molecular functions related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.16 ITGA2 ITGB3
2 extracellular matrix binding GO:0050840 8.96 ITGA2B ITGB3
3 fibrinogen binding GO:0070051 8.62 ITGA2B ITGB3

Sources for Fetal and Neonatal Alloimmune Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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