NAIT
MCID: FTL012
MIFTS: 47

Fetal and Neonatal Alloimmune Thrombocytopenia (NAIT)

Categories: Blood diseases, Fetal diseases, Immune diseases, Rare diseases
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Aliases & Classifications for Fetal and Neonatal Alloimmune Thrombocytopenia

MalaCards integrated aliases for Fetal and Neonatal Alloimmune Thrombocytopenia:

Name: Fetal and Neonatal Alloimmune Thrombocytopenia 19 58 28 5
Neonatal Alloimmune Thrombocytopenia 71 75
Nait 19 58
Fnait 58

Characteristics:


Prevelance:

1-5/10000 (Worldwide) >1/1000 (Worldwide) 58

Age Of Onset:

Antenatal,Neonatal 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 32 P61.0
UMLS via Orphanet 72 C3853779 C3854603
Orphanet 58 ORPHA853
UMLS 71 C3853779

Summaries for Fetal and Neonatal Alloimmune Thrombocytopenia

GARD: 19 Fetal and neonatal alloimmune thrombocytopenia (NAIT) is a blood disorder that affects pregnant women and their babies. NAIT was first reported in the literature in 1953 and is estimated to occur in as many as 1 in 1200 live births. NAIT results in the destruction of platelets in the fetus or infant due to a mismatch between the mother's platelets and those of the baby. Certain molecules (antigens) on the surface of the baby's platelets are recognized as foreign by the mother's immune system. The mother's immune system then creates antibodies that attack and destroy the baby's platelets. Though NAIT can occur whenever the mother's blood mixes with that of the baby, it is usually triggered when the mother is exposed to the baby's blood during delivery. Many cases of NAIT are mild. Signs and symptoms may include a low platelet count (thrombocytopenia) and signs of bleeding into the skin such as petechiae and purpura. In the most severe cases, NAIT can cause bleeding episodes that may result in death or long-term disability. Bleeding episodes can occur either during pregnancy or after birth.

MalaCards based summary: Fetal and Neonatal Alloimmune Thrombocytopenia, also known as neonatal alloimmune thrombocytopenia, is related to thrombocytopenia and myh-9 related disease. An important gene associated with Fetal and Neonatal Alloimmune Thrombocytopenia is CD109 (CD109 Molecule), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and PI3K-Akt signaling pathway. The drugs Immunologic Factors and Immunoglobulins, Intravenous have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and t cells, and related phenotypes are neonatal alloimmune thrombocytopenia and petechiae

Orphanet: 58 A rare hematological disease characterized by maternal alloimmunisation against fetal platelet antigens that are inherited from the father and different from those present in the mother, and usually presents as a severe isolated thrombocytopenia in otherwise healthy newborns.

Wikipedia: 75 Neonatal alloimmune thrombocytopenia (NAITP, NAIT, NATP or NAT) is a disease that affects babies in... more...

Related Diseases for Fetal and Neonatal Alloimmune Thrombocytopenia

Diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenia 30.3 ITGB3 ITGA2B ITGA2 GP1BB GP1BA
2 myh-9 related disease 30.0 GP1BB GP1BA
3 qualitative platelet defect 29.8 ITGA2B GP1BA
4 hemorrhagic disease 29.7 ITGA2B GP1BA
5 thrombocytopenia due to platelet alloimmunization 29.6 ITGB3 ITGA2B ITGA2 GP1BA
6 myeloproliferative syndrome, transient 29.5 ITGB3 ITGA2B GP1BA
7 von willebrand's disease 29.5 ITGA2B GP1BB GP1BA
8 thrombocytopenic purpura, autoimmune 29.5 ITGB3 ITGA2B GP1BA
9 purpura 29.3 ITGB3 ITGA2B GP1BA
10 thrombasthenia 29.2 ITGB3 ITGA2B ITGA2 GP1BA
11 thrombosis 29.0 ITGB3 ITGA2B ITGA2 GP1BA
12 blood platelet disease 29.0 ITGB3 ITGA2B ITGA2 GP1BB GP1BA
13 glanzmann thrombasthenia 1 28.9 ITGB3 ITGA2B ITGA2 GP1BB GP1BA
14 hemolytic disease due to fetomaternal alloimmunization 10.5
15 hemorrhage, intracerebral 10.4
16 down syndrome 10.3
17 deficiency anemia 10.3
18 cerebral palsy 10.3
19 hydrocephalus, congenital, 1 10.3
20 hpa i recognition polymorphism, beta-globin-related 10.2
21 macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss 10.2
22 ceroid lipofuscinosis, neuronal, 5 10.2
23 disseminated intravascular coagulation 10.2
24 hydrops fetalis, nonimmune 10.2
25 toe syndactyly, telecanthus, and anogenital and renal malformations 10.2
26 platelet glycoprotein iv deficiency 10.2
27 graft-versus-host disease 10.2
28 tatton-brown-rahman syndrome 10.2
29 hemolytic disease of fetus and newborn, rh-induced 10.2
30 chorioamnionitis 10.2
31 porencephaly 10.2
32 neutropenia 10.2
33 persistent fetal circulation syndrome 10.2
34 iron metabolism disease 10.2
35 hemolytic anemia 10.2
36 viral infectious disease 10.2
37 primary agammaglobulinemia 10.2
38 neonatal alloimmune neutropenia 10.2
39 twin-reversed arterial perfusion sequence 10.2
40 noonan syndrome 1 10.1
41 pulmonary hemosiderosis 10.1
42 thrombocytopenia 2 10.1
43 dandy-walker syndrome 10.1
44 factor vii deficiency 10.1
45 3-methylglutaconic aciduria, type iii 10.1
46 schizencephaly 10.1
47 sjogren syndrome 10.1
48 thrombocytopenia 3 10.1
49 wiskott-aldrich syndrome 10.1
50 histiocytosis-lymphadenopathy plus syndrome 10.1

Graphical network of the top 20 diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia:



Diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia

Symptoms & Phenotypes for Fetal and Neonatal Alloimmune Thrombocytopenia

Human phenotypes related to Fetal and Neonatal Alloimmune Thrombocytopenia:

58 30 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neonatal alloimmune thrombocytopenia 58 30 Obligate (100%) Obligate (100%)
HP:0004809
2 petechiae 58 30 Frequent (33%) Frequent (79-30%)
HP:0000967
3 spontaneous hematomas 58 30 Frequent (33%) Frequent (79-30%)
HP:0007420
4 cephalohematoma 58 30 Frequent (33%) Frequent (79-30%)
HP:0012541
5 hematuria 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000790
6 ecchymosis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0031364
7 melena 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002249
8 global developmental delay 58 30 Very rare (1%) Very rare (<4-1%)
HP:0001263
9 blindness 58 30 Very rare (1%) Very rare (<4-1%)
HP:0000618
10 cerebral palsy 58 30 Very rare (1%) Very rare (<4-1%)
HP:0100021
11 subarachnoid hemorrhage 58 30 Very rare (1%) Very rare (<4-1%)
HP:0002138
12 bilateral sensorineural hearing impairment 58 30 Very rare (1%) Very rare (<4-1%)
HP:0008619
13 purpura 58 Frequent (79-30%)
14 gastrointestinal hemorrhage 58 Occasional (29-5%)
15 intracranial hemorrhage 58 Occasional (29-5%)
16 abnormality of the nervous system 58 Very rare (<4-1%)
17 abnormal bleeding 58 Frequent (79-30%)

Drugs & Therapeutics for Fetal and Neonatal Alloimmune Thrombocytopenia

Drugs for Fetal and Neonatal Alloimmune Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors
2 Immunoglobulins, Intravenous
3 gamma-Globulins
4 Rho(D) Immune Globulin
5 Isoantibodies
6 Immunoglobulins
7 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neurodevelopmental Outcome After Fetal Neonatal AlloImmune Thrombocytopenia Unknown status NCT04529382
2 A Multi-center Prospective Cohort Study on the Anti-HPA Antibodies Caused Neonatal Alloimmune Thrombocytopenia in Chinese Pregnant Women Unknown status NCT02934906
3 An Open-label, Single Centre, Exploratory Trial Investigating the Kinetics of Platelets Transfused to Healthy, Male Subjects Completed NCT03561909
4 Towards Routine HPA-screening in Pregnancy to Prevent FNAIT: Assessing Disease Burden and Optimising Risk Group Selection Completed NCT04067375
5 A Prospective, Natural History Study to Assess the Occurrence of HPA-1a Alloimmunization in Women Identified at Higher Risk for Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT) Recruiting NCT05345561

Search NIH Clinical Center for Fetal and Neonatal Alloimmune Thrombocytopenia

Genetic Tests for Fetal and Neonatal Alloimmune Thrombocytopenia

Genetic tests related to Fetal and Neonatal Alloimmune Thrombocytopenia:

# Genetic test Affiliating Genes
1 Fetal and Neonatal Alloimmune Thrombocytopenia 28

Anatomical Context for Fetal and Neonatal Alloimmune Thrombocytopenia

Organs/tissues related to Fetal and Neonatal Alloimmune Thrombocytopenia:

MalaCards : Brain, Skin, T Cells, Nk Cells, Monocytes, Whole Blood, Endothelial

Publications for Fetal and Neonatal Alloimmune Thrombocytopenia

Articles related to Fetal and Neonatal Alloimmune Thrombocytopenia:

(show top 50) (show all 419)
# Title Authors PMID Year
1
Subamniotic haemorrhage, a possible new presentation of fetal and neonatal alloimmune thrombocytopenia. 62
36470221 2022
2
New Horizons in Fetal and Neonatal Alloimmune Thrombocytopenia. 62
36368687 2022
3
Prophylactic administration of HPA-1a-specific antibodies prevents fetal/neonatal alloimmune thrombocytopenia in mice. 62
35881848 2022
4
Postnatal treatment for children with fetal and neonatal alloimmune thrombocytopenia: a multicentre, retrospective, cohort study. 62
36108655 2022
5
Clinical and laboratory predictors of fetal and neonatal alloimmune thrombocytopenia. 62
36239096 2022
6
ABO Incompatibility between the Mother and Fetus Does Not Protect against Anti-Human Platelet Antigen-1a Immunization by Pregnancy. 62
36431288 2022
7
Maternal alloimmune antibodies against HPA and HLA class I antigens are associated with reduced birthweight among healthy neonates delivered by Chinese women. 62
35871773 2022
8
Protecting the fetus from FNAIT. 62
36394907 2022
9
Long-term neurodevelopmental outcome in children after antenatal intravenous immune globulin treatment in fetal and neonatal alloimmune thrombocytopenia. 62
35671780 2022
10
Current perspective and scope of fetal therapy: part 2. 62
33135520 2022
11
Alloimmune Neutropenia in a Neonate: Case Report and Review of Literature. 62
36278616 2022
12
Severe course of COVID-19 in pregnant woman and newborn's alloimmune thrombocytopenia - case study and review of the literature. 62
36134762 2022
13
Antenatal intravenous immunoglobulins in pregnancies at risk of fetal and neonatal alloimmune thrombocytopenia: comparison of neonatal outcome in treated and nontreated pregnancies. 62
35500612 2022
14
Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia due to antibodies against human platelet antigen 1b: Case report and literature review. 62
35730350 2022
15
Severe Neonatal Alloimmune Thrombocytopenia in a Multiparous Female With No Prior History. 62
36158336 2022
16
[Serological Diagnosis and Clinical Data Analysis of Neonatal Alloimmune Thrombocytopenia]. 62
35981388 2022
17
Preliminary mechanism in fetal alloimmune thrombocytopenia associated with anti-HPA 15b antibodies. 62
35388576 2022
18
Anti-human platelet antigen-5b antibodies and fetal and neonatal alloimmune thrombocytopenia; incidental association or cause and effect? 62
35383895 2022
19
Generation of induced pluripotent stem cell line derived from FNAIT patient with CD36 deficiency mutations. 62
35305469 2022
20
Severe thrombocytopenia and intracranial hemorrhage in a newborn with Noonan syndrome and neonatal alloimmune thrombocytopenia. 62
34904514 2022
21
Noninvasive Prenatal Testing in Immunohematology-Clinical, Technical and Ethical Considerations. 62
35629001 2022
22
Cerebral vasculature exhibits dose-dependent sensitivity to thrombocytopenia that is limited to fetal/neonatal life. 62
35148538 2022
23
A case of Philadelphia chromosome-positive acute lymphocytic leukaemia with type I CD36 deficiency. 62
34125957 2022
24
Subamniotic Hemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia. 62
35021176 2022
25
Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody. 62
35074850 2022
26
Fetal and neonatal alloimmune thrombocytopenia: a late or missed diagnosis disease in fetal and perinatal health-care settings. 62
31973628 2022
27
Subamniotic Haemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia. 62
35970173 2022
28
Clinical characteristics of human platelet antigen (HPA)-1a and HPA-5b alloimmunised pregnancies and the association between platelet HPA-5b antibodies and symptomatic fetal neonatal alloimmune thrombocytopenia. 62
34402048 2021
29
Are HPA-5b antibodies a significant cause of FNAIT and associated bleeding or merely an incidental finding? 62
34402050 2021
30
Fighting anti-CD36-mediated FNAIT. 62
34735001 2021
31
Development of a Pathway for Multidisciplinary Neurodevelopmental Assessment and Diagnosis in Children and Young People. 62
34828746 2021
32
Successful prenatal therapy for anti-CD36-mediated severe FNAIT by deglycosylated antibodies in a novel murine model. 62
34041523 2021
33
[Management of high-risk pregnancies in a context of maternal antiplatelet alloimmunization: Expert opinion of the French-speaking working group]. 62
34464715 2021
34
The first reported case of neonatal alloimmune thrombocytopenia due to low-frequency human platelet antigen-6b antibodies in the United Kingdom. 62
34156106 2021
35
Preclinical evaluation of immunotherapeutic regimens for fetal/neonatal alloimmune thrombocytopenia. 62
34470046 2021
36
Practices and opinions of New Zealand veterinarians regarding control of bovine viral diarrhoea. 62
33879036 2021
37
New developments in fetal and neonatal alloimmune thrombocytopenia. 62
33839095 2021
38
A nait-associated and previously unreported mutation in the ITGB3 gene with a low frequency in the local population. 62
33724573 2021
39
Platelet CD36 deficiency is present in 2.6% of Arabian individuals and can cause NAIT and platelet refractoriness. 62
33822386 2021
40
Down syndrome with neonatal alloimmune thrombocytopenia due to anti-HLA A31 and B61 antibodies. 62
33569741 2021
41
Placental Complement Activation in Fetal and Neonatal Alloimmune Thrombocytopenia: An Observational Study. 62
34201864 2021
42
Neonatal Alloimmune Thrombocytopenia: A Concise Review. 62
32657948 2021
43
An Unusual Case of Severe Persistent Neonatal Thrombocytopenia in an Extremely Low Birth Weight, Extreme Preterm Neonate. 62
34414253 2021
44
Maternal Anti-HPA-1a Antibodies Increase Endothelial Cell Apoptosis and Permeability. 62
33975315 2021
45
Neonatal alloimmune thrombocytopenia due to anti-HPA 5a in a HPA-5a homozygous neonate. 62
32763115 2020
46
Hydrops fetalis associated with anti-CD36 antibodies in fetal and neonatal alloimmune thrombocytopenia: Possible underlying mechanism. 62
32720360 2020
47
Fetal and Neonatal Alloimmune Thrombocytopenia-New Prospects for Fetal Risk Assessment of HPA-1a-Negative Pregnant Women. 62
33039264 2020
48
Naturally occurring point mutation Cys460Trp located in the I-EGF1 domain of integrin β3 alters the binding of some anti-HPA-1a antibodies. 62
32770549 2020
49
A new efficient tool for non-invasive diagnosis of fetomaternal platelet antigen incompatibility. 62
32266719 2020
50
A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy? 62
32608103 2020

Variations for Fetal and Neonatal Alloimmune Thrombocytopenia

ClinVar genetic disease variations for Fetal and Neonatal Alloimmune Thrombocytopenia:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ITGB3 NM_000212.3(ITGB3):c.1373A>G (p.Asp458Gly) SNV Association
446505 rs1555572829 GRCh37: 17:45369617-45369617
GRCh38: 17:47292251-47292251
2 ITGA2 NM_002203.4(ITGA2):c.1594A>C (p.Ile532Leu) SNV Benign
353752 rs199808499 GRCh37: 5:52358751-52358751
GRCh38: 5:53062921-53062921

Expression for Fetal and Neonatal Alloimmune Thrombocytopenia

Search GEO for disease gene expression data for Fetal and Neonatal Alloimmune Thrombocytopenia.

Pathways for Fetal and Neonatal Alloimmune Thrombocytopenia

Pathways related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 ITGB3 ITGA2B ITGA2 GP1BB GP1BA CD109
2
Show member pathways
12.65 ITGB3 ITGA2B ITGA2
3
Show member pathways
12.65 ITGB3 ITGA2B ITGA2
4
Show member pathways
12.63 ITGB3 ITGA2B ITGA2
5
Show member pathways
12.59 ITGB3 ITGA2B ITGA2
6
Show member pathways
12.57 ITGB3 ITGA2B ITGA2
7
Show member pathways
12.55 ITGB3 ITGA2B ITGA2
8
Show member pathways
12.48 ITGB3 ITGA2B ITGA2
9
Show member pathways
12.45 ITGA2 ITGA2B ITGB3
10
Show member pathways
12.44 ITGB3 ITGA2B ITGA2
11
Show member pathways
12.34 ITGB3 ITGA2B ITGA2
12
Show member pathways
12.11 ITGB3 ITGA2B ITGA2
13
Show member pathways
12.1 ITGB3 ITGA2B ITGA2
14 12.01 ITGB3 ITGA2B ITGA2
15
Show member pathways
11.95 ITGB3 ITGA2B ITGA2
16
Show member pathways
11.93 ITGB3 ITGA2B ITGA2
17
Show member pathways
11.92 ITGA2 ITGA2B ITGB3
18
Show member pathways
11.83 ITGB3 ITGA2B ITGA2
19
Show member pathways
11.67 ITGB3 ITGA2B ITGA2
20 11.64 ITGA2B ITGA2
21 11.58 ITGA2 ITGA2B ITGB3
22 11.52 ITGB3 ITGA2B ITGA2 GP1BA
23 11.46 ITGB3 ITGA2B ITGA2
24 11.27 ITGB3 ITGA2B
25 11.24 ITGB3 ITGA2B ITGA2
26
Show member pathways
11.24 ITGB3 ITGA2B GP1BB GP1BA
27 11.19 ITGB3 ITGA2B
28 11.15 ITGB3 ITGA2B
29 11.13 ITGA2B ITGA2
30 11.07 ITGB3 ITGA2B
31
Show member pathways
10.93 ITGA2 GP1BB GP1BA
32 10.87 ITGB3 ITGA2B
33 10.77 ITGB3 ITGA2B
34 10.73 ITGB3 ITGA2B ITGA2
35 10.63 ITGB3 ITGA2B ITGA2 GP1BB

GO Terms for Fetal and Neonatal Alloimmune Thrombocytopenia

Cellular components related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.87 ITGB3 ITGA2B ITGA2 GP1BA
2 cell surface GO:0009986 9.85 ITGB3 ITGA2B ITGA2 GP1BA CD109
3 glycoprotein Ib-IX-V complex GO:1990779 9.56 GP1BB GP1BA
4 integrin complex GO:0008305 9.43 ITGB3 ITGA2B ITGA2
5 platelet alpha granule membrane GO:0031092 9.1 ITGB3 ITGA2B CD109

Biological processes related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cell-matrix adhesion GO:0007160 9.91 ITGB3 ITGA2B ITGA2
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 ITGB3 ITGA2
3 platelet aggregation GO:0070527 9.86 ITGB3 GP1BA
4 release of sequestered calcium ion into cytosol GO:0051209 9.85 GP1BB GP1BA
5 integrin-mediated signaling pathway GO:0007229 9.85 ITGB3 ITGA2B ITGA2
6 megakaryocyte development GO:0035855 9.83 GP1BB GP1BA
7 cell-substrate adhesion GO:0031589 9.81 ITGA2 ITGB3
8 cell adhesion GO:0007155 9.81 ITGB3 ITGA2B ITGA2 GP1BB GP1BA
9 positive regulation of smooth muscle cell migration GO:0014911 9.8 ITGB3 ITGA2
10 mesodermal cell differentiation GO:0048333 9.76 ITGB3 ITGA2
11 platelet activation GO:0030168 9.73 ITGB3 GP1BB GP1BA
12 positive regulation of platelet activation GO:0010572 9.71 GP1BA GP1BB
13 positive regulation of leukocyte migration GO:0002687 9.65 ITGB3 ITGA2
14 blood coagulation, intrinsic pathway GO:0007597 9.62 GP1BB GP1BA
15 hemostasis GO:0007599 9.54 GP1BB GP1BA
16 cell adhesion mediated by integrin GO:0033627 9.43 ITGB3 ITGA2B ITGA2
17 blood coagulation GO:0007596 9.17 ITGB3 ITGA2 GP1BB GP1BA

Molecular functions related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 9.26 ITGB3 ITGA2B
2 integrin binding GO:0005178 9.1 ITGB3 ITGA2B ITGA2

Sources for Fetal and Neonatal Alloimmune Thrombocytopenia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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