Fetal and Neonatal Alloimmune Thrombocytopenia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Fetal and neonatal alloimmune thrombocytopenia (NAIT) is a blood disorder that affects pregnant women and their babies. NAIT was first reported in the literature in 1953 and is estimated to occur in as many as 1 in 1200 live births. NAIT results in the destruction of platelets in the fetus or infant due to a mismatch between the mother's platelets and those of the baby. Certain molecules (antigens) on the surface of the baby's platelets are recognized as foreign by the mother's immune system. The mother's immune system then creates antibodies that attack and destroy the baby's platelets. Though NAIT can occur whenever the mother's blood mixes with that of the baby, it is usually triggered when the mother is exposed to the baby's blood during delivery. Many cases of NAIT are mild. Signs and symptoms may include a low platelet count (thrombocytopenia) and signs of bleeding into the skin such as petechiae and purpura. In the most severe cases, NAIT can cause bleeding episodes that may result in death or long-term disability. Bleeding episodes can occur either during pregnancy or after birth.

MalaCards based summary: Fetal and Neonatal Alloimmune Thrombocytopenia, also known as neonatal alloimmune thrombocytopenia, is related to thrombocytopenia and myh-9 related disease. An important gene associated with Fetal and Neonatal Alloimmune Thrombocytopenia is CD109 (CD109 Molecule), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and PI3K-Akt signaling pathway. The drugs Immunologic Factors and Immunoglobulins, Intravenous have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and t cells, and related phenotypes are neonatal alloimmune thrombocytopenia and petechiae

Orphanet: ⁵⁸ A rare hematological disease characterized by maternal alloimmunisation against fetal platelet antigens that are inherited from the father and different from those present in the mother, and usually presents as a severe isolated thrombocytopenia in otherwise healthy newborns.

Wikipedia: ⁷⁵ Neonatal alloimmune thrombocytopenia (NAITP, NAIT, NATP or NAT) is a disease that affects babies in... more...

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Related Diseases for Fetal and Neonatal Alloimmune Thrombocytopenia

Diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)

#	Related Disease	Score	Top Affiliating Genes
1	thrombocytopenia	30.3	ITGB3 ITGA2B ITGA2 GP1BB GP1BA
2	myh-9 related disease	30.0	GP1BB GP1BA
3	qualitative platelet defect	29.8	ITGA2B GP1BA
4	hemorrhagic disease	29.7	ITGA2B GP1BA
5	thrombocytopenia due to platelet alloimmunization	29.6	ITGB3 ITGA2B ITGA2 GP1BA
6	myeloproliferative syndrome, transient	29.5	ITGB3 ITGA2B GP1BA
7	von willebrand's disease	29.5	ITGA2B GP1BB GP1BA
8	thrombocytopenic purpura, autoimmune	29.5	ITGB3 ITGA2B GP1BA
9	purpura	29.3	ITGB3 ITGA2B GP1BA
10	thrombasthenia	29.2	ITGB3 ITGA2B ITGA2 GP1BA
11	thrombosis	29.0	ITGB3 ITGA2B ITGA2 GP1BA
12	blood platelet disease	29.0	ITGB3 ITGA2B ITGA2 GP1BB GP1BA
13	glanzmann thrombasthenia 1	28.9	ITGB3 ITGA2B ITGA2 GP1BB GP1BA
14	hemolytic disease due to fetomaternal alloimmunization	10.5
15	hemorrhage, intracerebral	10.4
16	down syndrome	10.3
17	deficiency anemia	10.3
18	cerebral palsy	10.3
19	hydrocephalus, congenital, 1	10.3
20	hpa i recognition polymorphism, beta-globin-related	10.2
21	macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	10.2
22	ceroid lipofuscinosis, neuronal, 5	10.2
23	disseminated intravascular coagulation	10.2
24	hydrops fetalis, nonimmune	10.2
25	toe syndactyly, telecanthus, and anogenital and renal malformations	10.2
26	platelet glycoprotein iv deficiency	10.2
27	graft-versus-host disease	10.2
28	tatton-brown-rahman syndrome	10.2
29	hemolytic disease of fetus and newborn, rh-induced	10.2
30	chorioamnionitis	10.2
31	porencephaly	10.2
32	neutropenia	10.2
33	persistent fetal circulation syndrome	10.2
34	iron metabolism disease	10.2
35	hemolytic anemia	10.2
36	viral infectious disease	10.2
37	primary agammaglobulinemia	10.2
38	neonatal alloimmune neutropenia	10.2
39	twin-reversed arterial perfusion sequence	10.2
40	noonan syndrome 1	10.1
41	pulmonary hemosiderosis	10.1
42	thrombocytopenia 2	10.1
43	dandy-walker syndrome	10.1
44	factor vii deficiency	10.1
45	3-methylglutaconic aciduria, type iii	10.1
46	schizencephaly	10.1
47	sjogren syndrome	10.1
48	thrombocytopenia 3	10.1
49	wiskott-aldrich syndrome	10.1
50	histiocytosis-lymphadenopathy plus syndrome	10.1

Graphical network of the top 20 diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia:

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Symptoms & Phenotypes for Fetal and Neonatal Alloimmune Thrombocytopenia

Human phenotypes related to Fetal and Neonatal Alloimmune Thrombocytopenia:

⁵⁸ ³⁰ (show all 17)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	neonatal alloimmune thrombocytopenia ⁵⁸ ³⁰	Obligate (100%)	Obligate (100%)	HP:0004809
2	petechiae ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000967
3	spontaneous hematomas ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0007420
4	cephalohematoma ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012541
5	hematuria ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000790
6	ecchymosis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0031364
7	melena ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002249
8	global developmental delay ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001263
9	blindness ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000618
10	cerebral palsy ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0100021
11	subarachnoid hemorrhage ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0002138
12	bilateral sensorineural hearing impairment ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0008619
13	purpura ⁵⁸		Frequent (79-30%)
14	gastrointestinal hemorrhage ⁵⁸		Occasional (29-5%)
15	intracranial hemorrhage ⁵⁸		Occasional (29-5%)
16	abnormality of the nervous system ⁵⁸		Very rare (<4-1%)
17	abnormal bleeding ⁵⁸		Frequent (79-30%)

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Drugs & Therapeutics for Fetal and Neonatal Alloimmune Thrombocytopenia

Drugs for Fetal and Neonatal Alloimmune Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Immunologic Factors
2	Immunoglobulins, Intravenous
3	gamma-Globulins
4	Rho(D) Immune Globulin
5	Isoantibodies
6	Immunoglobulins
7	Antibodies

Interventional clinical trials:

#	Name	Status	NCT ID
1	Neurodevelopmental Outcome After Fetal Neonatal AlloImmune Thrombocytopenia	Unknown status	NCT04529382
2	A Multi-center Prospective Cohort Study on the Anti-HPA Antibodies Caused Neonatal Alloimmune Thrombocytopenia in Chinese Pregnant Women	Unknown status	NCT02934906
3	An Open-label, Single Centre, Exploratory Trial Investigating the Kinetics of Platelets Transfused to Healthy, Male Subjects	Completed	NCT03561909
4	Towards Routine HPA-screening in Pregnancy to Prevent FNAIT: Assessing Disease Burden and Optimising Risk Group Selection	Completed	NCT04067375
5	A Prospective, Natural History Study to Assess the Occurrence of HPA-1a Alloimmunization in Women Identified at Higher Risk for Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)	Recruiting	NCT05345561

Search NIH Clinical Center for Fetal and Neonatal Alloimmune Thrombocytopenia

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Genetic Tests for Fetal and Neonatal Alloimmune Thrombocytopenia

Genetic tests related to Fetal and Neonatal Alloimmune Thrombocytopenia:

#	Genetic test	Affiliating Genes
1	Fetal and Neonatal Alloimmune Thrombocytopenia ²⁸

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Anatomical Context for Fetal and Neonatal Alloimmune Thrombocytopenia

Organs/tissues related to Fetal and Neonatal Alloimmune Thrombocytopenia:

MalaCards : Brain, Skin, T Cells, Nk Cells, Monocytes, Whole Blood, Endothelial

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Publications for Fetal and Neonatal Alloimmune Thrombocytopenia

Articles related to Fetal and Neonatal Alloimmune Thrombocytopenia:

(show top 50) (show all 419)

#	Title	Authors	PMID	Year
1	Subamniotic haemorrhage, a possible new presentation of fetal and neonatal alloimmune thrombocytopenia. ⁶²	Jaiman S	36470221	2022
2	New Horizons in Fetal and Neonatal Alloimmune Thrombocytopenia. ⁶²	Barg A...Bonstein L	36368687	2022
3	Prophylactic administration of HPA-1a-specific antibodies prevents fetal/neonatal alloimmune thrombocytopenia in mice. ⁶²	Zhi H...Newman PJ	35881848	2022
4	Postnatal treatment for children with fetal and neonatal alloimmune thrombocytopenia: a multicentre, retrospective, cohort study. ⁶²	de Vos TW...Lopriore E	36108655	2022
5	Clinical and laboratory predictors of fetal and neonatal alloimmune thrombocytopenia. ⁶²	Matusiak K...Arnold DM	36239096	2022
6	ABO Incompatibility between the Mother and Fetus Does Not Protect against Anti-Human Platelet Antigen-1a Immunization by Pregnancy. ⁶²	Miserre L...Bein G	36431288	2022
7	Maternal alloimmune antibodies against HPA and HLA class I antigens are associated with reduced birthweight among healthy neonates delivered by Chinese women. ⁶²	Xue Y...Zhao T	35871773	2022
8	Protecting the fetus from FNAIT. ⁶²	Semple JW...Kapur R	36394907	2022
9	Long-term neurodevelopmental outcome in children after antenatal intravenous immune globulin treatment in fetal and neonatal alloimmune thrombocytopenia. ⁶²	de Vos TW...van Klink JMM	35671780	2022
10	Current perspective and scope of fetal therapy: part 2. ⁶²	Sharma D...Tsibizova VI	33135520	2022
11	Alloimmune Neutropenia in a Neonate: Case Report and Review of Literature. ⁶²	Prasath A...Nair J	36278616	2022
12	Severe course of COVID-19 in pregnant woman and newborn's alloimmune thrombocytopenia - case study and review of the literature. ⁶²	Piotrowska-Gwizdak A...Jakimiuk A	36134762	2022
13	Antenatal intravenous immunoglobulins in pregnancies at risk of fetal and neonatal alloimmune thrombocytopenia: comparison of neonatal outcome in treated and nontreated pregnancies. ⁶²	Ernstsen SL...Tiller H	35500612	2022
14	Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia due to antibodies against human platelet antigen 1b: Case report and literature review. ⁶²	Tomac G...Golubic Cepulic B	35730350	2022
15	Severe Neonatal Alloimmune Thrombocytopenia in a Multiparous Female With No Prior History. ⁶²	Judd T...Tomsic MP	36158336	2022
16	[Serological Diagnosis and Clinical Data Analysis of Neonatal Alloimmune Thrombocytopenia]. ⁶²	Zhou C...Chen XJ	35981388	2022
17	Preliminary mechanism in fetal alloimmune thrombocytopenia associated with anti-HPA 15b antibodies. ⁶²	Shao Y...Fu Y	35388576	2022
18	Anti-human platelet antigen-5b antibodies and fetal and neonatal alloimmune thrombocytopenia; incidental association or cause and effect? ⁶²	Alm J...Bein G	35383895	2022
19	Generation of induced pluripotent stem cell line derived from FNAIT patient with CD36 deficiency mutations. ⁶²	Chen D...Fu Y	35305469	2022
20	Severe thrombocytopenia and intracranial hemorrhage in a newborn with Noonan syndrome and neonatal alloimmune thrombocytopenia. ⁶²	Carter R...Niemi AK	34904514	2022
21	Noninvasive Prenatal Testing in Immunohematology-Clinical, Technical and Ethical Considerations. ⁶²	Kjeldsen-Kragh J...Hellberg A	35629001	2022
22	Cerebral vasculature exhibits dose-dependent sensitivity to thrombocytopenia that is limited to fetal/neonatal life. ⁶²	Farley AM...Taoudi S	35148538	2022
23	A case of Philadelphia chromosome-positive acute lymphocytic leukaemia with type I CD36 deficiency. ⁶²	Matsui M...Kozai Y	34125957	2022
24	Subamniotic Hemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia. ⁶²	Giesbers S...van Drongelen J	35021176	2022
25	Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody. ⁶²	Mortberg TV...Ahlen MT	35074850	2022
26	Fetal and neonatal alloimmune thrombocytopenia: a late or missed diagnosis disease in fetal and perinatal health-care settings. ⁶²	Blanco S...Gallego SV	31973628	2022
27	Subamniotic Haemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia. ⁶²	Maisonneuve E...Bertrand G	35970173	2022
28	Clinical characteristics of human platelet antigen (HPA)-1a and HPA-5b alloimmunised pregnancies and the association between platelet HPA-5b antibodies and symptomatic fetal neonatal alloimmune thrombocytopenia. ⁶²	de Vos TW...de Haas M	34402048	2021
29	Are HPA-5b antibodies a significant cause of FNAIT and associated bleeding or merely an incidental finding? ⁶²	Curtis BR	34402050	2021
30	Fighting anti-CD36-mediated FNAIT. ⁶²	Ahlen MT	34735001	2021
31	Development of a Pathway for Multidisciplinary Neurodevelopmental Assessment and Diagnosis in Children and Young People. ⁶²	Rutherford M...Forsyth K	34828746	2021
32	Successful prenatal therapy for anti-CD36-mediated severe FNAIT by deglycosylated antibodies in a novel murine model. ⁶²	Xu X...Santoso S	34041523	2021
33	[Management of high-risk pregnancies in a context of maternal antiplatelet alloimmunization: Expert opinion of the French-speaking working group]. ⁶²	Bertrand G...working group on fetomaternal platelet alloimmunization of the GFHT	34464715	2021
34	The first reported case of neonatal alloimmune thrombocytopenia due to low-frequency human platelet antigen-6b antibodies in the United Kingdom. ⁶²	Hopkins M...Poles A	34156106	2021
35	Preclinical evaluation of immunotherapeutic regimens for fetal/neonatal alloimmune thrombocytopenia. ⁶²	Zhi H...Newman PJ	34470046	2021
36	Practices and opinions of New Zealand veterinarians regarding control of bovine viral diarrhoea. ⁶²	Gates MC...Weston JF	33879036	2021
37	New developments in fetal and neonatal alloimmune thrombocytopenia. ⁶²	Bussel JB...Berkowitz RL	33839095	2021
38	A nait-associated and previously unreported mutation in the ITGB3 gene with a low frequency in the local population. ⁶²	Norrenbrock S...Doescher A	33724573	2021
39	Platelet CD36 deficiency is present in 2.6% of Arabian individuals and can cause NAIT and platelet refractoriness. ⁶²	Flesch BK...Zeiler T	33822386	2021
40	Down syndrome with neonatal alloimmune thrombocytopenia due to anti-HLA A31 and B61 antibodies. ⁶²	Shima E...Hosoya M	33569741	2021
41	Placental Complement Activation in Fetal and Neonatal Alloimmune Thrombocytopenia: An Observational Study. ⁶²	de Vos TW...de Haas M	34201864	2021
42	Neonatal Alloimmune Thrombocytopenia: A Concise Review. ⁶²	Norton T...Jnah A	32657948	2021
43	An Unusual Case of Severe Persistent Neonatal Thrombocytopenia in an Extremely Low Birth Weight, Extreme Preterm Neonate. ⁶²	Paul M...Varghese D	34414253	2021
44	Maternal Anti-HPA-1a Antibodies Increase Endothelial Cell Apoptosis and Permeability. ⁶²	Dardik R...Salomon O	33975315	2021
45	Neonatal alloimmune thrombocytopenia due to anti-HPA 5a in a HPA-5a homozygous neonate. ⁶²	Porta R...Lozano M	32763115	2020
46	Hydrops fetalis associated with anti-CD36 antibodies in fetal and neonatal alloimmune thrombocytopenia: Possible underlying mechanism. ⁶²	Wu Y...Fu Y	32720360	2020
47	Fetal and Neonatal Alloimmune Thrombocytopenia-New Prospects for Fetal Risk Assessment of HPA-1a-Negative Pregnant Women. ⁶²	Kjeldsen-Kragh J...Bengtsson J	33039264	2020
48	Naturally occurring point mutation Cys460Trp located in the I-EGF1 domain of integrin β3 alters the binding of some anti-HPA-1a antibodies. ⁶²	Holzwarth ST...Santoso S	32770549	2020
49	A new efficient tool for non-invasive diagnosis of fetomaternal platelet antigen incompatibility. ⁶²	Ouzegdouh Mammasse Y...Petermann R	32266719	2020
50	A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy? ⁶²	Dahl J...Tiller H	32608103	2020

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Genes for Fetal and Neonatal Alloimmune Thrombocytopenia

Genes related to Fetal and Neonatal Alloimmune Thrombocytopenia (6 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CD109	CD109 Molecule	Protein Coding	25	Candidate gene tested ⁵⁸
2	GP1BA	Glycoprotein Ib Platelet Subunit Alpha	Protein Coding	25	Candidate gene tested ⁵⁸
3	GP1BB	Glycoprotein Ib Platelet Subunit Beta	Protein Coding	25	Candidate gene tested ⁵⁸
4	ITGA2	Integrin Subunit Alpha 2	Protein Coding	25	Candidate gene tested ⁵⁸
5	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	25	Candidate gene tested ⁵⁸
6	ITGB3	Integrin Subunit Beta 3	Protein Coding	25	Susceptibility factor ⁵⁸	19821948

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Variations for Fetal and Neonatal Alloimmune Thrombocytopenia

ClinVar genetic disease variations for Fetal and Neonatal Alloimmune Thrombocytopenia:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	ITGB3	NM_000212.3(ITGB3):c.1373A>G (p.Asp458Gly)	SNV	Association	446505	rs1555572829	GRCh37: 17:45369617-45369617 GRCh38: 17:47292251-47292251
2	ITGA2	NM_002203.4(ITGA2):c.1594A>C (p.Ile532Leu)	SNV	Benign	353752	rs199808499	GRCh37: 5:52358751-52358751 GRCh38: 5:53062921-53062921

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Expression for Fetal and Neonatal Alloimmune Thrombocytopenia

Search GEO for disease gene expression data for Fetal and Neonatal Alloimmune Thrombocytopenia.

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Pathways for Fetal and Neonatal Alloimmune Thrombocytopenia

Pathways related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 35)

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.8	ITGB3 ITGA2B ITGA2 GP1BB GP1BA CD109
2	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.65	ITGB3 ITGA2B ITGA2
3	Actin Nucleation by ARP-WASP Complex ⁶⁴ Show member pathways Actin Nucleation and Branching ⁶⁴ CDC42 Pathway ⁶⁴ RhoA Pathway ⁶⁴	12.65	ITGB3 ITGA2B ITGA2
4	Sertoli-Sertoli Cell Junction Dynamics ⁶⁴ Show member pathways Epithelial Tight Junctions ⁶⁴ Germ Cell-Sertoli Cell Junction Dynamics ⁶⁴	12.63	ITGB3 ITGA2B ITGA2
5	Beta-Adrenergic Signaling ⁶⁴ Show member pathways CDK5 Pathway ⁶⁴ Erythropoietin Pathway ⁶⁴ Insulin Pathway ⁷⁰ Insulin Receptor Pathway ⁶⁴	12.59	ITGB3 ITGA2B ITGA2
6	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.57	ITGB3 ITGA2B ITGA2
7	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.55	ITGB3 ITGA2B ITGA2
8	DREAM Repression and Dynorphin Expression ⁶⁴ Show member pathways Arrhythmogenic right ventricular cardiomyopathy ⁷⁴ BMP Pathway ⁶⁴ Calpain Protease Regulates Cellular Mechanics ⁶⁴ Caspase Cascade ⁶⁴ nNOS Signaling in Skeletal Muscle ⁶⁴ Presynaptic depolarization and calcium channel opening ⁶⁶ TOB in Osteoblast Signaling ⁶⁴	12.48	ITGB3 ITGA2B ITGA2
9	MAPK-Erk Pathway ⁶⁷ Show member pathways Actin Dynamics Signaling Pathway ⁶⁷ G Protein-coupled Receptors Signaling ⁶⁷	12.45	ITGA2 ITGA2B ITGB3
10	Extracellular matrix organization ⁶⁶ Show member pathways Degradation of the extracellular matrix ⁶⁶	12.44	ITGB3 ITGA2B ITGA2
11	Complement cascade ⁶⁶ Show member pathways Activation of C3 and C5 ⁶⁶ Classical Complement Pathway ⁶⁴ Complement Pathway ⁶⁴ Complement system ⁷⁴ Complement system in neuronal development and plasticity ⁷⁴ Lectin Induced Complement Pathway ⁶⁴ Regulation of Complement cascade ⁶⁶	12.34	ITGB3 ITGA2B ITGA2
12	Autophagy pathway ⁶⁷ Show member pathways AKT Signaling Pathway ⁶⁷	12.11	ITGB3 ITGA2B ITGA2
13	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ⁶¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ⁶¹	12.1	ITGB3 ITGA2B ITGA2
14	Focal adhesion ⁷⁴	12.01	ITGB3 ITGA2B ITGA2
15	L1CAM interactions ⁶⁶ Show member pathways CHL1 interactions ⁶⁶ Neurofascin interactions ⁶⁶ NrCAM interactions ⁶⁶ Recycling pathway of L1 ⁶⁶	11.95	ITGB3 ITGA2B ITGA2
16	Integrin-mediated cell adhesion ⁷⁴ Show member pathways HGF Pathway ⁶⁴	11.93	ITGB3 ITGA2B ITGA2
17	MAPK Signaling: Mitogens ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	11.92	ITGA2 ITGA2B ITGB3
18	ECM proteoglycans ⁶⁶ Show member pathways Integrin cell surface interactions ⁶⁶ MED and pseudoachondroplasia genes ⁷⁴	11.83	ITGB3 ITGA2B ITGA2
19	Integrin family cell surface interactions ⁶¹ Show member pathways Phagocytosis of Microbes ⁶⁴ Plexin-D1 Signaling ⁶¹	11.67	ITGB3 ITGA2B ITGA2
20	Small cell lung cancer ⁷⁴	11.64	ITGA2B ITGA2
21	Reelin Pathway (Cajal-Retzius cells) ⁶⁴	11.58	ITGA2 ITGA2B ITGB3
22	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.52	ITGB3 ITGA2B ITGA2 GP1BA
23	G-protein signaling_RhoA regulation pathway ²²	11.46	ITGB3 ITGA2B ITGA2
24	Signaling events mediated by PTP1B ⁶¹	11.27	ITGB3 ITGA2B
25	Cytoskeleton remodeling_RalA regulation pathway ²²	11.24	ITGB3 ITGA2B ITGA2
26	Integrin signaling ⁶⁶ Show member pathways GRB2:SOS provides linkage to MAPK signaling for Integrins ⁶⁶ p130Cas linkage to MAPK signaling for integrins ⁶⁶ Platelet Aggregation (Plug Formation) ⁶⁶	11.24	ITGB3 ITGA2B GP1BB GP1BA
27	Beta3 integrin cell surface interactions ⁶¹	11.19	ITGB3 ITGA2B
28	Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction ⁶⁰	11.15	ITGB3 ITGA2B
29	Articular Cartilage Extracellular Matrix ⁶⁵	11.13	ITGA2B ITGA2
30	Arf6 signaling events ⁶¹	11.07	ITGB3 ITGA2B
31	Platelet Adhesion to exposed collagen ⁶⁶ Show member pathways GP1b-IX-V activation signalling ⁶⁶	10.93	ITGA2 GP1BB GP1BA
32	Signal transduction by L1 ⁶⁶	10.87	ITGB3 ITGA2B
33	Ephrin B reverse signaling ⁶¹	10.77	ITGB3 ITGA2B
34	G-protein signaling_Rap2B regulation pathway ²²	10.73	ITGB3 ITGA2B ITGA2
35	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶⁰	10.63	ITGB3 ITGA2B ITGA2 GP1BB

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GO Terms for Fetal and Neonatal Alloimmune Thrombocytopenia

Cellular components related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.87	ITGB3 ITGA2B ITGA2 GP1BA
2	cell surface	GO:0009986	9.85	ITGB3 ITGA2B ITGA2 GP1BA CD109
3	glycoprotein Ib-IX-V complex	GO:1990779	9.56	GP1BB GP1BA
4	integrin complex	GO:0008305	9.43	ITGB3 ITGA2B ITGA2
5	platelet alpha granule membrane	GO:0031092	9.1	ITGB3 ITGA2B CD109

Biological processes related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-matrix adhesion	GO:0007160	9.91	ITGB3 ITGA2B ITGA2
2	positive regulation of smooth muscle cell proliferation	GO:0048661	9.87	ITGB3 ITGA2
3	platelet aggregation	GO:0070527	9.86	ITGB3 GP1BA
4	release of sequestered calcium ion into cytosol	GO:0051209	9.85	GP1BB GP1BA
5	integrin-mediated signaling pathway	GO:0007229	9.85	ITGB3 ITGA2B ITGA2
6	megakaryocyte development	GO:0035855	9.83	GP1BB GP1BA
7	cell-substrate adhesion	GO:0031589	9.81	ITGA2 ITGB3
8	cell adhesion	GO:0007155	9.81	ITGB3 ITGA2B ITGA2 GP1BB GP1BA
9	positive regulation of smooth muscle cell migration	GO:0014911	9.8	ITGB3 ITGA2
10	mesodermal cell differentiation	GO:0048333	9.76	ITGB3 ITGA2
11	platelet activation	GO:0030168	9.73	ITGB3 GP1BB GP1BA
12	positive regulation of platelet activation	GO:0010572	9.71	GP1BA GP1BB
13	positive regulation of leukocyte migration	GO:0002687	9.65	ITGB3 ITGA2
14	blood coagulation, intrinsic pathway	GO:0007597	9.62	GP1BB GP1BA
15	hemostasis	GO:0007599	9.54	GP1BB GP1BA
16	cell adhesion mediated by integrin	GO:0033627	9.43	ITGB3 ITGA2B ITGA2
17	blood coagulation	GO:0007596	9.17	ITGB3 ITGA2 GP1BB GP1BA

Molecular functions related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix binding	GO:0050840	9.26	ITGB3 ITGA2B
2	integrin binding	GO:0005178	9.1	ITGB3 ITGA2B ITGA2

Sources

Sources for Fetal and Neonatal Alloimmune Thrombocytopenia

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

NAIT MCID: FTL012 MIFTS: 47	Fetal and Neonatal Alloimmune Thrombocytopenia (NAIT) Categories: Blood diseases, Fetal diseases, Immune diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

Fetal and Neonatal Alloimmune Thrombocytopenia (NAIT)

Aliases & Classifications for Fetal and Neonatal Alloimmune Thrombocytopenia

MalaCards integrated aliases for Fetal and Neonatal Alloimmune Thrombocytopenia:

Characteristics:

Prevelance:

Age Of Onset:

Classifications:

External Ids:

Summaries for Fetal and Neonatal Alloimmune Thrombocytopenia

Related Diseases for Fetal and Neonatal Alloimmune Thrombocytopenia

Diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia:

Symptoms & Phenotypes for Fetal and Neonatal Alloimmune Thrombocytopenia

Human phenotypes related to Fetal and Neonatal Alloimmune Thrombocytopenia:

Drugs & Therapeutics for Fetal and Neonatal Alloimmune Thrombocytopenia

Drugs for Fetal and Neonatal Alloimmune Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Fetal and Neonatal Alloimmune Thrombocytopenia

Genetic tests related to Fetal and Neonatal Alloimmune Thrombocytopenia:

Anatomical Context for Fetal and Neonatal Alloimmune Thrombocytopenia

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Publications for Fetal and Neonatal Alloimmune Thrombocytopenia

Articles related to Fetal and Neonatal Alloimmune Thrombocytopenia:

Genes for Fetal and Neonatal Alloimmune Thrombocytopenia

Genes related to Fetal and Neonatal Alloimmune Thrombocytopenia (6 elite genes):

Variations for Fetal and Neonatal Alloimmune Thrombocytopenia

ClinVar genetic disease variations for Fetal and Neonatal Alloimmune Thrombocytopenia:

Expression for Fetal and Neonatal Alloimmune Thrombocytopenia

Pathways for Fetal and Neonatal Alloimmune Thrombocytopenia

Pathways related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

GO Terms for Fetal and Neonatal Alloimmune Thrombocytopenia

Cellular components related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

Biological processes related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

Molecular functions related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

Sources for Fetal and Neonatal Alloimmune Thrombocytopenia