NAIT
MCID: FTL012
MIFTS: 43

Fetal and Neonatal Alloimmune Thrombocytopenia (NAIT)

Categories: Blood diseases, Fetal diseases, Immune diseases, Rare diseases

Aliases & Classifications for Fetal and Neonatal Alloimmune Thrombocytopenia

MalaCards integrated aliases for Fetal and Neonatal Alloimmune Thrombocytopenia:

Name: Fetal and Neonatal Alloimmune Thrombocytopenia 53 59 6
Nait 53 59
Neonatal Alloimmune Thrombocytopenia 72
Fnait 59

Classifications:



External Ids:

ICD10 via Orphanet 34 P61.0
UMLS via Orphanet 73 C3853779 C3854603
Orphanet 59 ORPHA853
UMLS 72 C3853779

Summaries for Fetal and Neonatal Alloimmune Thrombocytopenia

NIH Rare Diseases : 53 Fetal and neonatal alloimmune thrombocytopenia (NAIT) is a blood disorder that affects pregnant women and their babies. NAIT was first reported in the literature in 1953 and is estimated to occur in as many as 1 in 1200 live births. NAIT results in the destruction of platelets in the fetus or infant due to a mismatch between the mother's platelets and those of the baby. Certain molecules (antigens) on the surface of the baby's platelets are recognized as foreign by the mother's immune system. The mother's immune system then creates antibodies that attack and destroy the baby's platelets. Though NAIT can occur whenever the mother's blood mixes with that of the baby, it is usually triggered when the mother is exposed to the baby's blood during delivery. Many cases of NAIT are mild. Signs and symptoms may include a low platelet count (thrombocytopenia) and signs of bleeding into the skin such as petechiae and purpura. In the most severe cases, NAIT can cause bleeding episodes that may result in death or long-term disability. Bleeding episodes can occur either during pregnancy or after birth. Management of the infant with neonatal alloimmune thrombocytopenia may include platelet transfusions, ultrasounds, and intravenous immunoglobulin (IVIG). Treatment for pregnant mothers at risk for NAIT may include IVIG and steroids.

MalaCards based summary : Fetal and Neonatal Alloimmune Thrombocytopenia, also known as nait, is related to purpura and thrombocytopenia due to platelet alloimmunization. An important gene associated with Fetal and Neonatal Alloimmune Thrombocytopenia is ITGB3 (Integrin Subunit Beta 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Actin Nucleation by ARP-WASP Complex. The drugs Antibodies and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and t cells, and related phenotypes are neonatal alloimmune thrombocytopenia and spontaneous hematomas

Wikipedia : 75 Neonatal alloimmune thrombocytopenia (NAITP, NAIT, NATP or NAT) is a disease that affects babies in... more...

Related Diseases for Fetal and Neonatal Alloimmune Thrombocytopenia

Diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 40, show less)
# Related Disease Score Top Affiliating Genes
1 purpura 29.6 ITGB3 ITGA2B GP1BB
2 thrombocytopenia due to platelet alloimmunization 29.3 ITGB3 ITGA2B ITGA2
3 thrombocytopenia 29.1 ITGB3 ITGA2B ITGA2 GP1BB GP1BA
4 hydrocephalus 10.2
5 congenital hydrocephalus 10.2
6 triiodothyronine receptor auxiliary protein 10.1
7 down syndrome 10.1
8 yemenite deaf-blind hypopigmentation syndrome 10.1
9 branchiootic syndrome 1 10.1
10 graft-versus-host disease 10.1
11 chorioamnionitis 10.1
12 porencephaly 10.1
13 neutropenia 10.1
14 cerebral palsy 10.1
15 iron metabolism disease 10.1
16 hemolytic anemia 10.1
17 hemolytic disease due to fetomaternal alloimmunization 10.1
18 neonatal alloimmune neutropenia 10.1
19 bleeding disorder, platelet-type, 16 10.1 ITGB3 ITGA2B
20 myeloproliferative syndrome, transient 10.0 ITGB3 GP1BA
21 coronary thrombosis 10.0 ITGB3 GP1BA
22 arteritic anterior ischemic optic neuropathy 10.0 ITGB3 GP1BA
23 infective endocarditis 9.9 ITGB3 GP1BA
24 aspirin resistance 9.8 ITGB3 ITGA2
25 pseudo-von willebrand disease 9.8 GP1BB GP1BA
26 thrombocytopenic purpura, autoimmune 9.7 ITGB3 ITGA2B GP1BA
27 hemorrhagic disease 9.7 ITGA2B GP1BA
28 essential thrombocythemia 9.6 ITGB3 ITGA2B GP1BA
29 velocardiofacial syndrome 9.4 GP1BB GP1BA
30 autosomal dominant macrothrombocytopenia 9.2 ITGB3 ITGA2B GP1BB GP1BA
31 inherited blood coagulation disease 9.1 ITGB3 ITGA2B GP1BB GP1BA
32 blood coagulation disease 9.1 ITGB3 ITGA2B GP1BB GP1BA
33 blood platelet disease 9.1 ITGB3 ITGA2B GP1BB GP1BA
34 primary thrombocytopenia 9.0 ITGB3 ITGA2B ITGA2 GP1BA
35 autoimmune disease of blood 8.9 ITGB3 ITGA2B ITGA2 GP1BA
36 von willebrand disease, type 2 8.9 ITGB3 ITGA2B ITGA2 GP1BA
37 thrombasthenia 8.9 ITGB3 ITGA2B ITGA2 GP1BA
38 glanzmann thrombasthenia 8.9 ITGB3 ITGA2B ITGA2 GP1BA
39 myocardial infarction 8.8 ITGB3 ITGA2B ITGA2 GP1BA
40 bernard-soulier syndrome 8.4 ITGB3 ITGA2B ITGA2 GP1BB GP1BA

Graphical network of the top 20 diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia:



Diseases related to Fetal and Neonatal Alloimmune Thrombocytopenia

Symptoms & Phenotypes for Fetal and Neonatal Alloimmune Thrombocytopenia

Human phenotypes related to Fetal and Neonatal Alloimmune Thrombocytopenia:

59 32 (showing 17, show less)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neonatal alloimmune thrombocytopenia 59 32 obligate (100%) Obligate (100%) HP:0004809
2 spontaneous hematomas 59 32 frequent (33%) Frequent (79-30%) HP:0007420
3 petechiae 59 32 frequent (33%) Frequent (79-30%) HP:0000967
4 cephalohematoma 59 32 frequent (33%) Frequent (79-30%) HP:0012541
5 hematuria 59 32 occasional (7.5%) Occasional (29-5%) HP:0000790
6 ecchymosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0031364
7 melena 59 32 occasional (7.5%) Occasional (29-5%) HP:0002249
8 global developmental delay 59 32 very rare (1%) Very rare (<4-1%) HP:0001263
9 blindness 59 32 very rare (1%) Very rare (<4-1%) HP:0000618
10 cerebral palsy 59 32 very rare (1%) Very rare (<4-1%) HP:0100021
11 subarachnoid hemorrhage 59 32 very rare (1%) Very rare (<4-1%) HP:0002138
12 bilateral sensorineural hearing impairment 59 32 very rare (1%) Very rare (<4-1%) HP:0008619
13 abnormal bleeding 59 Frequent (79-30%)
14 gastrointestinal hemorrhage 59 Occasional (29-5%)
15 purpura 59 Frequent (79-30%)
16 abnormality of the nervous system 59 Very rare (<4-1%)
17 intracranial hemorrhage 59 Occasional (29-5%)

Drugs & Therapeutics for Fetal and Neonatal Alloimmune Thrombocytopenia

Drugs for Fetal and Neonatal Alloimmune Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 6, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunologic Factors
3 Immunoglobulins
4 gamma-Globulins
5 Immunoglobulins, Intravenous
6 Rho(D) Immune Globulin

Interventional clinical trials:

(showing 4, show less)
# Name Status NCT ID Phase Drugs
1 An Open-label, Single Centre, Exploratory Trial Investigating the Kinetics of Platelets Transfused to Healthy, Male Subjects Completed NCT03561909
2 Mathematical Modeling to Predict the Duration of Thrombocytopenia in Neonates Active, not recruiting NCT02802982
3 A Multi-center Prospective Cohort Study on the Anti-HPA Antibodies Caused Neonatal Alloimmune Thrombocytopenia in Chinese Pregnant Women Not yet recruiting NCT02934906
4 Incidence and Risk Factors for Neonatal Thrombocytopenia Among Newborns Admitted to Neonatal Intensive Care Unit of Assiut University Children Hospital Not yet recruiting NCT03448952

Search NIH Clinical Center for Fetal and Neonatal Alloimmune Thrombocytopenia

Genetic Tests for Fetal and Neonatal Alloimmune Thrombocytopenia

Anatomical Context for Fetal and Neonatal Alloimmune Thrombocytopenia

MalaCards organs/tissues related to Fetal and Neonatal Alloimmune Thrombocytopenia:

41
Brain, Skin, T Cells, Monocytes, Placenta, B Cells, Whole Blood

Publications for Fetal and Neonatal Alloimmune Thrombocytopenia

Articles related to Fetal and Neonatal Alloimmune Thrombocytopenia:

(showing 297, show less)
# Title Authors PMID Year
1
Prenatal Management of Pregnancies at Risk of Fetal Neonatal Alloimmune Thrombocytopenia (FNAIT): Scientific Impact Paper No. 61. 38
30968555 2019
2
Novel method for simultaneously detecting HPA and HLA antibodies using Luminex microbeads. 38
31382976 2019
3
Assessing the use of diagnostic laboratory accession data to support national bovine viral diarrhoea control in New Zealand. 38
31023158 2019
4
Fast and low-cost direct ELISA for high-throughput serological HPA-1a typing. 38
31329320 2019
5
Timely diagnosis and treatment of neonatal alloimmune thrombocytopenia caused by anti HPA-3a antibody: A case report. 38
31083173 2019
6
Fetal and neonatal alloimmune thrombocytopenia: recommendations for evidence-based practice, an international approach. 38
30828796 2019
7
Management of neonatal thrombocytopenia in a context of maternal antiplatelet alloimmunization: Expert opinion of the French-speaking working group. 38
30827773 2019
8
HLA-DRB3*01:01 exhibits a dose-dependent impact on HPA-1a antibody levels in HPA-1a-immunized women. 38
30923048 2019
9
Postnatal intervention for the treatment of FNAIT: a systematic review. 38
30971767 2019
10
Marked thrombocytopenia in a neonate is associated with anti-HPA-5b, anti-HLA-A31, and anti-HLA-B55 antibodies. 38
30488611 2019
11
Neonatal Alloimmune Thrombocytopenia: A Report of Four Cases. 38
31327862 2019
12
[FETAL/NEONATAL ALLOIMMUNE THROMBOCYTOPENIA (F/NAIT) - THE PREVALENCE VERSUS AWARENESS OF A LIFE-THREATENING CLINICAL CONDITION]. 38
30916500 2019
13
Perinatal Outcome and Long-Term Neurodevelopment after Intracranial Haemorrhage due to Fetal and Neonatal Alloimmune Thrombocytopenia. 38
29730660 2019
14
Management and Neonatal Outcomes of Pregnancies with Fetal/Neonatal Alloimmune Thrombocytopenia: A Single-Center Retrospective Cohort Study. 38
29669341 2019
15
Neonatal alloimmune thrombocytopenia due to a new alloantigen Bl(a) defined by an Asp458Gly substitution in GPIIIa. 38
30488955 2019
16
From thrombasthenia to next generation thrombocytopenia: Neonatal alloimmune thrombocytopenia induced by maternal Glanzmann thrombasthenia. 38
30216638 2018
17
Implication of antibodies against human leukocyte antigen in simultaneous presentation of fetal and neonatal alloimmune thrombocytopenia and neutropenia. 38
30318177 2018
18
Investigations for fetal and neonatal alloimmune thrombocytopenia: communication from the SSC of the ISTH. 38
30382606 2018
19
Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia. 38
30701924 2018
20
Identification and follow-up of pregnant women with platelet-type human platelet antigen (HPA)-1bb alloimmunized with fetal HPA-1a. 38
30154886 2018
21
Screening for fetal and neonatal alloimmune thrombocytopenia - lessons learned from a Norwegian screening program. 38
29412452 2018
22
Neonatal Alloimmune Thrombocytopenia With Amegakaryocytosis, B Lymphopenia, and Villitis. 38
29610181 2018
23
Adding to the complexity of fetal and neonatal alloimmune thrombocytopenia: Reduced fibrinogen binding in the presence of anti-HPA-1a antibody and hypo-responsive neonatal platelets. 38
29306729 2018
24
Fetal and neonatal alloimmune thrombocytopenia. 38
30848151 2018
25
Intracranial hemorrhages in neonates born from 32 weeks of gestation-low frequency of associated fetal and neonatal alloimmune thrombocytopenia: a register-based study. 38
29119564 2018
26
Differential diagnosis of neonatal alloimmune thrombocytopenia: Type 2B von Willebrand disease. 38
28436749 2017
27
Imaging and management of fetuses and neonates with alloimmune thrombocytopenia. 38
28675682 2017
28
Contemporary management of neonatal alloimmune thrombocytopenia: good outcomes in the intravenous immunoglobulin era: results from the Australian neonatal alloimmune thrombocytopenia registry. 38
27806668 2017
29
[Thirty years of platelet immunology in fetal and neonatal alloimmune thrombocytopenia management, current situation]. 38
28673503 2017
30
A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother. 38
28097780 2017
31
Fetal and neonatal alloimmune thrombocytopenia: evidence based antenatal and postnatal management strategies. 38
28644735 2017
32
Neonatal alloimmune thrombocytopenia caused by anti-HPA antibodies in pregnant Chinese women: a study protocol for a multicentre, prospective cohort trial. 38
28859622 2017
33
Unraveling the role of maternal anti-HLA class I antibodies in fetal and neonatal thrombocytopenia-Antibody specificity analysis using epitope data. 38
28686909 2017
34
Cab4b, the first human platelet antigen carried by glycoprotein IX discovered in a context of severe neonatal thrombocytopenia. 38
28561420 2017
35
Women's attitude towards routine human platelet antigen-screening in pregnancy. 38
28401538 2017
36
Neonatal alloimmune thrombocytopaenia associated with maternal HLA antibodies. 38
28679510 2017
37
IVIG-Associated Maternal Pancytopenia during Treatment for Neonatal Alloimmune Thrombocytopenia. 38
28970962 2017
38
Low-dose prednisone and immunoglobulin G treatment for woman at risk for neonatal alloimmune thrombocytopenia and T helper 1 immunity. 38
28240400 2017
39
Human platelet antigen antibody induction in uncomplicated pregnancy is associated with HLA sensitization. 38
28295360 2017
40
Specific immunoglobulin E and immunoglobulin G4 toward major allergens of house-dust mite during allergen-specific immunotherapy. 38
28490399 2017
41
Fatal alloimmune thrombocytopenia due to anti-HLA alloimmunization in a twin pregnancy: A very infrequent complication of assisted reproduction. 38
27839964 2017
42
Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model. 38
28427432 2017
43
HLA-DRB3*01:01 is a predictor of immunization against human platelet antigen-1a but not of the severity of fetal and neonatal alloimmune thrombocytopenia. 38
28019029 2017
44
Recent advances in understanding the clinical relevance of antiplatelet alloantibodies. 38
28377559 2017
45
Antenatal management in fetal and neonatal alloimmune thrombocytopenia: a systematic review. 38
28130210 2017
46
Maternal HLA genotyping is not useful for predicting severity of fetal and neonatal alloimmune thrombocytopenia. 38
27748520 2017
47
Fetal and Neonatal Alloimmune Thrombocytopenia: Management and Outcome of a Large International Retrospective Cohort. 38
27728915 2017
48
Current perspectives on fetal and neonatal alloimmune thrombocytopenia - increasing clinical concerns and new treatment opportunities. 38
28458583 2017
49
Association between Fetal Cerebral Ventriculomegaly and Platelet Alloimmunisation. 38
27597992 2017
50
Fetal exposure to maternal human platelet antigen-1a does not induce tolerance. An analytical observational study. 38
28837581 2017
51
Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond. 38
27282765 2016
52
Placental histological lesions in fetal and neonatal alloimmune thrombocytopenia: A retrospective cohort study of 21 cases. 38
27871460 2016
53
Blood group A mothers are more likely to develop anemia during antenatal intravenous immunoglobulin treatment of fetal and neonatal alloimmune thrombocytopenia. 38
27611703 2016
54
T cell responses to human platelet antigen-1a involve a unique form of indirect allorecognition. 38
27699233 2016
55
Lower-dose intravenous immunoglobulins for the treatment of fetal and neonatal alloimmune thrombocytopenia: a cohort study. 38
27383293 2016
56
Sensitive detection of platelet-specific antibodies with a modified MAIPA using biotinylated antibodies and streptavidin-coated beads. 38
27059653 2016
57
Perinatal Coxsackievirus B3 Infection with Transient Thrombocytopenia. 38
27250900 2016
58
Triplets with neonatal alloimmune thrombocytopenia due to antibodies against human platelet antigen 1a. 38
26813079 2016
59
Compatibility between livestock databases used for quantitative biosecurity response in New Zealand. 38
26556178 2016
60
Severe bleeding complications other than intracranial hemorrhage in neonatal alloimmune thrombocytopenia: a case series and review of the literature. 38
26996515 2016
61
CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. 38
26634302 2016
62
Maternal anti-HLA class I antibodies are associated with reduced birth weight in thrombocytopenic neonates. 38
26547815 2016
63
Fetal and neonatal alloimmune thrombocytopenia. 38
26810319 2016
64
Extreme Elevation of Alkaline Phosphatase in a Pregnancy Complicated by Gestational Diabetes and Infant with Neonatal Alloimmune Thrombocytopenia. 38
27610256 2016
65
What do we know about intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia? 38
26756707 2016
66
Anti-Human Platelet Antigen-1a Immunoglobulin G Preparation Intended to Prevent Fetal and Neonatal Alloimmune Thrombocytopenia. 38
27627660 2016
67
Fetal and neonatal alloimmune thrombocytopenia: predictive factors of intracranial hemorrhage. 38
26469867 2016
68
Non-invasive Prenatal Diagnosis of Feto-Maternal Platelet Incompatibility by Cold High Resolution Melting Analysis. 38
27753021 2016
69
Alloantibody against new platelet alloantigen (Lap(a)) on glycoprotein IIb is responsible for a case of fetal and neonatal alloimmune thrombocytopenia. 38
26388194 2015
70
Recent progress in understanding the pathogenesis of fetal and neonatal alloimmune thrombocytopenia. 38
26344048 2015
71
Suppression of in vitro megakaryopoiesis by maternal sera containing anti-HPA-1a antibodies. 38
26209661 2015
72
Characterization of a human platelet antigen-1a-specific monoclonal antibody derived from a B cell from a woman alloimmunized in pregnancy. 38
25972474 2015
73
Noninvasive fetal genotyping of human platelet antigen-1a using targeted massively parallel sequencing. 38
25873286 2015
74
Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia. 38
28345015 2015
75
A Rare Case of Neonatal Alloimmune Thrombocytopenia Causing Prolonged Postcircumcision Bleeding. 38
25872699 2015
76
Recurrent HLA-B56 mediated neonatal alloimmune thrombocytopenia with fatal outcomes. 38
25634791 2015
77
Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage. 38
25774504 2015
78
Low-Dose versus Standard-Dose Intravenous Immunoglobulin to Prevent Fetal Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia: A Randomized Trial. 38
25896635 2015
79
Review of fetal and neonatal immune cytopenias. 38
25679972 2015
80
DOWN'S SYNDROME WITH NEONATAL ALLOIMMUNE THROMBOCYTOPENIA DUE TO HLA-A2 ANTIBODY. 38
26632192 2015
81
A case of neonatal alloimmune thrombocytopenia in the presence of both anti-HPA-4b and anti-HPA-5b antibody: clinical and serological analysis of the subsequent pregnancy. 38
24972694 2014
82
How do we treat fetal and neonatal alloimmune thrombocytopenia? 38
24773309 2014
83
A rare manifestation of neonatal alloimmune thrombocytopaenia. 38
24891486 2014
84
Low-frequency human platelet antigens as triggers for neonatal alloimmune thrombocytopenia. 38
24128174 2014
85
Incidence and consequences of neonatal alloimmune thrombocytopenia: a systematic review. 38
24590747 2014
86
Human platelet antigen (HPA)-1a peptides do not reliably suppress anti-HPA-1a responses using a humanized severe combined immunodeficiency (SCID) mouse model. 38
24261689 2014
87
H435-containing immunoglobulin G3 allotypes are transported efficiently across the human placenta: implications for alloantibody-mediated diseases of the newborn. 38
23829325 2014
88
Management of infants born with severe neonatal alloimmune thrombocytopenia: the role of platelet transfusions and intravenous immunoglobulin. 38
23869512 2014
89
Core fucosylation and IgG function in NAIT. 38
24458274 2014
90
Antibody formation in pregnant women with maternal-neonatal human platelet antigen mismatch from a hospital in northern Taiwan. 38
24388055 2014
91
Identification of potential platelet alloantigens in the Equidae family by comparison of gene sequences encoding major platelet membrane glycoproteins. 38
24117539 2013
92
Co-stimulation with LPS or Poly I:C markedly enhances the anti-platelet immune response and severity of fetal and neonatal alloimmune thrombocytopenia. 38
24067944 2013
93
The implementation of surface plasmon resonance technique in monitoring pregnancies with expected fetal and neonatal alloimmune thrombocytopenia. 38
23278334 2013
94
Human platelet-specific antigen frequencies in Indonesian population. 38
23617356 2013
95
Safe fetal platelet genotyping: new developments. 38
23146000 2013
96
Mechanisms and prevention of alloimmunization in pregnancy. 38
23803755 2013
97
A platelet cover-up. 38
23869075 2013
98
Modified antibody in fetal alloimmunization. 38
23869072 2013
99
Hematologic complications of pregnancy. 38
23953339 2013
100
Diagnosis and management of neonatal alloimmune thrombocytopenia in pregnancy. 38
23702120 2013
101
Prevalence and clinical significance of low-avidity HPA-1a antibodies in women exposed to HPA-1a during pregnancy. 38
23003125 2013
102
Development of a single-antigen magnetic bead assay (SAMBA) for the sensitive detection of HPA-1a alloantibodies using tag-engineered recombinant soluble β3 integrin. 38
23454035 2013
103
Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management. 38
23384054 2013
104
Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry. 38
23524102 2013
105
Maternal hemolysis after intravenous immunoglobulin treatment in fetal and neonatal alloimmune thrombocytopenia. 38
23344412 2013
106
Massive intracranial hemorrhage caused by neonatal alloimmune thrombocytopenia associated with anti-group A antibody. 38
23269231 2013
107
Neonatal alloimmune thrombocytopenia associated with massive chronic intervillositis: a case report and review of the literature. 38
23113771 2013
108
Fetal and neonatal alloimmune thrombocytopenia. 38
23687553 2013
109
Fetal and neonatal alloimmune thrombocytopenia. 38
23482913 2012
110
Delayed diagnosis of fetal and neonatal alloimmune thrombocytopenia: a cause of perinatal mortality and morbidity. 38
23078538 2012
111
Review of neonatal alloimmune thrombocytopenia. 38
22970675 2012
112
Human platelet antigen genotypes in Turkish and Caucasian blood donors in Germany. 38
22681418 2012
113
A review of the contemporary management of fetal and neonatal alloimmune thrombocytopenia in an Australian tertiary obstetric hospital. 38
22510050 2012
114
The first two cases of neonatal alloimmune thrombocytopenia associated with the low-frequency platelet antigen HPA-21bw (Nos) in Japan. 38
22211425 2012
115
Would it be possible to prevent HPA-1a alloimmunization to reduce the incidence of fetal and neonatal alloimmune thrombocytopenia? 38
22780891 2012
116
Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody-mediated immune suppression and prevention of severe clinical complications in a murine model. 38
22251227 2012
117
Determination of human platelet antigen typing by molecular methods: Importance in diagnosis and early treatment of neonatal alloimmune thrombocytopenia. 38
22345051 2012
118
New platelet glycoprotein polymorphisms causing maternal immunization and neonatal alloimmune thrombocytopenia. 38
22070736 2012
119
The relevance of HPA-15 antigen expression for anti-HPA-15 antibody detection. 38
21752233 2012
120
A point mutation in the EGF-4 domain of β(3) integrin is responsible for the formation of the Sec(a) platelet alloantigen and affects receptor function. 38
22116617 2012
121
Human platelet antigen 1a epitopes are dependent on the cation-regulated conformation of integrin α(IIb)β(3) (GPIIb/IIIa). 38
22036924 2012
122
Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries. 38
23008717 2012
123
The development of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO genotypes. 38
22110529 2012
124
How I manage neonatal thrombocytopenia. 38
21950766 2012
125
Platelet antibodies and fetal growth: maternal antibodies against fetal platelet antigen 1a are strongly associated with reduced birthweight in boys. 38
21895612 2012
126
Are maternal antiplatelet antibodies a prothrombotic condition leading to miscarriage? 38
22019585 2011
127
Fetal and neonatal alloimmune thrombocytopenia: a management algorithm based on risk stratification. 38
22015886 2011
128
Neonatal alloimmune thrombocytopenia: a case study. 38
22052120 2011
129
Low-avidity anti-HPA-1a alloantibodies are capable of antigen-positive platelet destruction in the NOD/SCID mouse model of alloimmune thrombocytopenia. 38
21564107 2011
130
A new platelet alloantigen, Swi(a) , located on glycoprotein Ia identified in a family with fetal and neonatal alloimmune thrombocytopenia. 38
21332723 2011
131
The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia. 38
21708486 2011
132
[Fetal and neonatal alloimmune thrombocytopenia]. 38
21867657 2011
133
Fetal and neonatal alloimmune thrombocytopenia: prenatal interventions. 38
21618560 2011
134
A review of pathophysiology and current treatment for neonatal alloimmune thrombocytopenia (NAIT) and introducing the Australian NAIT registry. 38
21631435 2011
135
Transfusion medicine and the pregnant patient. 38
21444037 2011
136
Fetal and neonatal alloimmune thrombocytopenia: harvesting the evidence to develop a clinical approach to management. 38
20700860 2011
137
Alloantibodies to glycoprotein La/LLa (anti-HPA-5a and -5b) and IIb/IIIa (anti-HPA1a, -3a and -4a) in Nigerian parous women. 38
21473260 2011
138
Screening in pregnancy for fetal or neonatal alloimmune thrombocytopenia: systematic review. 38
20618318 2010
139
Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention. 38
21083473 2010
140
Quantitative MAIPA: Comparison of different MAIPA protocols. 38
20675194 2010
141
Platelet antibody screening by flow cytometry is more sensitive than solid phase red cell adherence assay and lymphocytotoxicity technique: a comparative study in Thai patients. 38
21038788 2010
142
Neonatal alloimmune thrombocytopenia caused by an antibody specific for a newly identified allele of human platelet antigen-7. 38
20070614 2010
143
The first case of alloantibody against human platelet antigen-15b in Japan: possible alloimmunization by a hydatidiform mole. 38
20030792 2010
144
Neonatal alloimmune thrombocytopenia caused by anti-HLA-A24 alloantibodies. 38
19912145 2010
145
Cerebellar loss and brain-stem atrophy associated with neonatal alloimmune thrombocytopenia in a discordant twin. 38
19589002 2010
146
Neonatal alloimmune thrombocytopenia is not what it was: a lesson learned from a large prospective screening and intervention program. 38
19906194 2009
147
Platelet-specific alloantigens and antibodies in Tunisian women after three or more pregnancies. 38
19747290 2009
148
Neonatal alloimmune thrombocytopenia due to HPA-9b incompatibility. 38
19459189 2009
149
Processed platelet HPA1a peptides au naturel. 38
19713478 2009
150
Diagnosis and management of the fetus and neonate with alloimmune thrombocytopenia. 38
19630811 2009
151
Neonatal alloimmune thrombocytopenia and neutropenia associated with maternal human leukocyte antigen antibodies. 38
19229975 2009
152
Low-avidity HPA-1a alloantibodies in severe neonatal alloimmune thrombocytopenia are detectable with surface plasmon resonance technology. 38
19175553 2009
153
Human platelet antigen typing of neonatal alloimmune thrombocytopenia patients using whole genome amplified DNA and a 5'-nuclease assay. 38
19175554 2009
154
T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells. 38
19136661 2009
155
Neonatal alloimmune thrombocytopenia in Norway: poor detection rate with nonscreening versus a general screening programme. 38
19250370 2009
156
Current approaches to the evaluation and management of the fetus and neonate with immune thrombocytopenia. 38
19167580 2009
157
Blockade of maternal anti-HPA-1a-mediated platelet clearance by an HPA-1a epitope-specific F(ab') in an in vivo mouse model of alloimmune thrombocytopenia. 38
19000229 2009
158
Direct comparison between two quantitative assays in the measurement of maternal anti-HPA-1a antibody in neonatal alloimmune thrombocytopenia (NAIT). 38
18945639 2008
159
What's happening--probing of HPA-1a antigen-antibody interaction by surface plasmon resonance technology. 38
18710823 2008
160
Ultrastructural localization of glycoprotein IIIa (GPIIIa, beta 3 integrin) on placental syncytiotrophoblast microvilli: implications for platelet alloimmunization during pregnancy. 38
18673340 2008
161
Genotyping for human platelet alloantigen polymorphisms: applications in the diagnosis of alloimmune platelet disorders. 38
19085653 2008
162
Fetal thrombocytopenia. 38
18400574 2008
163
Neonatal thrombocytopenia. 38
18378508 2008
164
Neonatal isoimmune thrombocytopenia caused by type I CD36 deficiency having novel splicing isoforms of the CD36 gene. 38
18462250 2008
165
Is it time to include screening for neonatal alloimmune thrombocytopenia in the general antenatal health care programme? 38
18499524 2008
166
Heterogeneity of HPA-3 alloantibodies: consequences for the diagnosis of alloimmune thrombocytopenic syndromes. 38
18067506 2008
167
Fetal and neonatal alloimmune thrombocytopenia. 38
17936686 2008
168
A systematic review and survey of the management of unexpected neonatal alloimmune thrombocytopenia. 38
17894790 2008
169
Fetal and neonatal alloimmune thrombocytopenia: progress and ongoing debates. 38
17981381 2008
170
Severe HPA-15b related neonatal alloimmune thrombocytopenia. 38
17850392 2007
171
Postnatal management of fetal and neonatal alloimmune thrombocytopenia: the role of matched platelet transfusion and IVIG. 38
17177068 2007
172
[Intravenous human immunoglobulin treatment for neonatal alloimmune thrombocytopenia due to anti-HPA-5b with severe previous history]. 38
17590318 2007
173
A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia. 38
17429009 2007
174
Intrauterine use of hyperconcentrated platelet concentrates collected with Trima Accel in a case of neonatal alloimmune thrombocytopenia. 38
17655593 2007
175
Rapid detection of HPA-1 alloantibodies by platelet antigens immobilized onto microbeads. 38
17655579 2007
176
Blood product replacement in the perinatal period. 38
17825684 2007
177
HPA-13bw neonatal alloimmune thrombocytopenia and low frequency alloantigens: case report and review of the literature. 38
17655596 2007
178
Cost-effectiveness of antenatal screening for neonatal alloimmune thrombocytopenia. 38
17355359 2007
179
Noninvasive antenatal management of fetal and neonatal alloimmune thrombocytopenia: safe and effective. 38
17309545 2007
180
An unusual case of severe neonatal thrombocytopenia. 38
17605445 2007
181
[Is a non-invasive management allowed for maternofetal alloimmune thrombocytopenia? Experience over a 10-year period]. 38
17306591 2007
182
[Case report of a rare platelet-specific antigen HPA-10bw allele found in Chinese mainland]. 38
17369172 2007
183
Maternal human platelet antigen-1a antibody level correlates with the platelet count in the newborns: a retrospective study. 38
17207230 2007
184
Congenital posthemorrhagic hydrocephalus: a case of fetomaternal alloimmune thrombocytopenia. 38
17556816 2007
185
Long-term effects of fetal and neonatal alloimmune thrombocytopenia and its antenatal treatment on the medical and developmental outcomes of affected children. 38
17094038 2006
186
Foetal and neonatal alloimmune thrombocytopaenia. 38
17032445 2006
187
Vaginal delivery for fetuses at risk of alloimmune thrombocytopenia? 38
16827760 2006
188
Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT). 38
16403916 2006
189
Neonatal alloimmune thrombocytopenia caused by human leucocyte antigen-B27 antibody. 38
16623921 2006
190
A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. 38
16317099 2006
191
Prospective epidemiologic study of the outcome and cost-effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia due to anti-HPA-1a. 38
16371049 2005
192
Light chain phenotypes of HLA antibodies in cases with suspected neonatal alloimmune thrombocytopenia. 38
16262761 2005
193
What's happening? The expanding role of apheresis platelet support in neonatal alloimmune thrombocytopenia: current status and future trends. 38
16140039 2005
194
Reactivity of T cells from women with antibodies to the human platelet antigen (HPA)-1a to peptides encompassing the HPA-1 polymorphism. 38
16178861 2005
195
The cost effectiveness of empiric intravenous immunoglobulin for the antepartum treatment of fetal and neonatal alloimmune thrombocytopenia. 38
16157118 2005
196
From an early National Blood Foundation award to our ongoing studies in fetal and neonatal alloimmune thrombocytopenia. 38
16086790 2005
197
Collaborative study to establish the first international standard for quantitation of anti-HPA-1a. 38
16101692 2005
198
Immunization against a low-frequency human platelet alloantigen in fetal alloimmune thrombocytopenia is not a single event: characterization by the combined use of reference DNA and novel allele-specific cell lines expressing recombinant antigens. 38
15752152 2005
199
Relevance of the HPA-15 (Gov) polymorphism on CD109 in alloimmune thrombocytopenic syndromes. 38
15752154 2005
200
Fetal and neonatal alloimmune thrombocytopenia in pregnancies involving in vitro fertilization: a report of four cases. 38
15696000 2005
201
Is there a relationship between anti-HPA-1a concentration and severity of neonatal alloimmune thrombocytopenia? 38
16178667 2005
202
Management of bleeding disorders in children. 38
16304413 2005
203
Gene frequencies of the HPA-1 to 6 and Gov human platelet antigens in Thai blood donors. 38
15783299 2005
204
Survey of the use and clinical effectiveness of HPA-1a/5b-negative platelet concentrates in proven or suspected platelet alloimmunization. 38
15569235 2004
205
Fetal and neonatal alloimmune thrombocytopenia. 38
16163250 2004
206
Effect of maternal anti-HPA-1a antibodies and polyclonal IVIG on the activation status of vascular endothelial cells. 38
15196265 2004
207
Human platelet alloantigens (HPAs): PCR-SSP genotyping of a UK population for 15 HPA alleles. 38
14675395 2003
208
Gene frequencies of the HPA-1 to HPA-13, Oe and Gov platelet antigen alleles in Taiwanese, Indonesian, Filipino and Thai populations. 38
12964043 2003
209
Report on the Eleventh International Society of Blood Transfusion Platelet Genotyping and Serology Workshop. 38
12925172 2003
210
Neonatal alloimmune thrombocytopenia may be less severe in a subsequent pregnancy. 38
12775537 2003
211
Serologic analysis of three cases of neonatal alloimmune thrombocytopenia associated with HLA antibodies. 38
12823751 2003
212
[Influences of active immunotherapy on T helper cell type 1 and 2 cytokines in women with unexplained habitual abortion]. 38
12895381 2003
213
Anti-HPA-1a-mediated platelet phagocytosis by monocytes in vitro and its inhibition by Fc gamma receptor (FcgammaR) reactive reagents. 38
12581186 2003
214
Neonatal alloimmune thrombocytopenia due to anti-HPA-5b (Bra). 38
15373678 2003
215
Neonatal alloimmune thrombocytopenia due to anti-HPA-2b (anti-Koa). 38
15373693 2003
216
Incidental diagnosis and tempestive therapy in a case of neonatal alloimmune thrombocytopenia due to anti-HPA-5b. 38
12487835 2002
217
Neonatal alloimmune thrombocytopenia: antenatal and postnatal imaging findings in the pediatric brain. 38
12372732 2002
218
Fetal and neonatal thrombopoietin levels in alloimmune thrombocytopenia. 38
12084855 2002
219
Neonatal alloimmune thrombocytopenia with significant HLA antibodies. 38
11978754 2002
220
Neonatal alloimmune thrombocytopenia. 38
11886574 2002
221
A functional platelet fibrinogen receptor with a deletion in the cysteine-rich repeat region of the beta(3) integrin: the Oe(a) alloantigen in neonatal alloimmune thrombocytopenia. 38
11830467 2002
222
Neonatal alloimmune thrombocytopenia due to HPA-3a antibodies: a case report. 38
15373561 2002
223
HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams. 38
12012640 2002
224
Neonatal alloimmune thrombocytopenia due to anti-human leukocyte antigen antibody: a case report. 38
11764101 2001
225
Platelet glycoprotein complex Ia/IIa antibodies cause neonatal alloimmune thrombocytopenia but do not inhibit megakaryopoiesis and platelet recovery after allogeneic cord blood stem cell transplantation. 38
11781636 2001
226
Human platelet antigen-1a antibodies induce the release of the chemokine RANTES from human platelets. 38
11703865 2001
227
Human platelet alloantigens. 38
11732116 2001
228
A less invasive treatment strategy to prevent intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia. 38
11568798 2001
229
Anti-HPA-3A induces severe neonatal alloimmune thrombocytopenia. 38
11391330 2001
230
Neonatal alloimmune thrombocytopenia due to anti-Nak(a). 38
11274593 2001
231
HPA-1a-mediated platelet interaction with monocytes in vitro: involvement of Fcgamma receptor (FcgammaR) classes and inhibition by humanised monoclonal anti-FcgammaRI H22. 38
11168497 2000
232
[Feto-maternal incompatibility due to the platelet specific antigens: frequency, diagnosis and general rules of management]. 38
11082939 2000
233
Neonatal thrombocytopenia in two of six human platelet alloantigen (HPA) 5a-positive children of an HPA-5a-immunized mother. 38
10760207 2000
234
Platelets: New Understanding of Platelet Glycoproteins and Their Role in Disease. 38
11701544 2000
235
Neonatal and maternal thrombocytopenia: incidence and immune background. 38
10680704 2000
236
Construction of a human platelet alloantigen-1a epitope(s) within murine glycoprotein IIIa: identification of residues critical to the conformation of the antibody binding site(s). 38
10216091 1999
237
An international trial demonstrates suitability of a newly developed whole-blood ELISA kit for multicentre platelet HPA-1 phenotyping. 38
10516555 1999
238
Typing for human platelet alloantigens. 38
11253950 1999
239
Management of fetal and neonatal alloimmune thrombocytopenia. 38
9784630 1998
240
Gene frequencies of eight human platelet-specific antigens in Koreans. 38
9675790 1998
241
Neonatal alloimmune thrombocytopenia associated with maternal anti-HLA antibody: a case report. 38
9628438 1998
242
Rapid screening of platelet donors for PlA1 (HPA-1a) alloantigen using a solid-phase microplate immunoassay. 38
15377179 1998
243
Clinical aspects and typing of platelet alloantigens. 38
9704466 1998
244
[Transplacental alloimmunization against specific platelet antigens: prevalence and features in a Chilean population]. 38
9609020 1997
245
Intravenous immunoglobulin g therapy in fetal and neonatal alloimmune thrombocytopenia. 38
18020518 1997
246
[Neonatal alloimmune thrombocytopenia]. 38
9301295 1997
247
Neonatal thrombocytopenia: incidence, serological and clinical observations. 38
9263562 1997
248
Maternal DRB1*1501, DQA1*0102, DQB1*0602 haplotype in fetomaternal alloimmunization against human platelet alloantigen HPA-6b (GPIIIa-Gln489). 38
9271820 1997
249
HPA-10w(b) (La(a)): genetic determination of a new platelet-specific alloantigen on glycoprotein IIIa and its expression in COS-7 cells. 38
9116286 1997
250
[Neonatal alloimmune thrombopenia in anti-HPA-3a (Baka) immunization]. 38
9183406 1997
251
Prenatal diagnosis and management of neonatal alloimmune thrombocytopenia. 38
9190033 1997
252
[Alloimmune neonatal thrombocytopenia caused by serologic incompatibility of HPA-1a platelet antigen--case report]. 38
9289446 1996
253
Fetal alloimmune thrombocytopenia: consensus and controversy. 38
8930800 1996
254
Management of fetal and neonatal alloimmune thrombocytopenia. 38
8809972 1996
255
Antenatal invasive and noninvasive management of alloimmune thrombocytopenia. 38
8739589 1996
256
Devastating sequelae of alloimmune thrombocytopenia: an entity that deserves more attention. 38
8796784 1996
257
Genetic susceptibility and anti-human platelet antigen 5b alloimmunization role of HLA class II and TAP genes. 38
8727210 1996
258
[Severe neonatal alloimmune thrombocytopenia with delayed antibody detection]. 38
8974689 1996
259
Maternal alloimmunization against fetal platelet antigens: a prospective study. 38
7647006 1995
260
Fetal and neonatal thrombocytopenia. 38
7580391 1995
261
Neonatal alloimmune thrombocytopenia involving HPA-5b (Br(a)): a rare Japanese case. 38
7645398 1995
262
Fetal bleeding in neonatal alloimmune thrombocytopenia mediated by anti-PlAl is not associated with inhibition of fibrinogen binding to platelet GPIIb/IIIa. 38
7741112 1995
263
Neonatal alloimmune thrombocytopenia in Taiwan due to an antibody against a labile component of HPA-3a (Baka). 38
8751303 1995
264
Alloimmunization against Iy, a low-frequency antigen on platelet glycoprotein Ib/IX as a cause of severe neonatal alloimmune thrombocytopenic purpura. 38
8578740 1995
265
[Neonatal alloimmune thrombocytopenia]. 38
7813921 1994
266
Susceptibility to alloimmunization to platelet HPA-1a antigen involves TAP1 polymorphism. 38
7860359 1994
267
Rhesus sensitization and alloimmune thrombocytopenia. 38
7985045 1994
268
Expression and purification of functional recombinant epitopes for the platelet antigens, PlA1 and PlA2. 38
7519475 1994
269
Localization of the Br polymorphism on a 144 bp exon of the GPIa gene and its application in platelet DNA typing. 38
7916494 1994
270
Anti-Bak(a) neonatal alloimmune thrombocytopenia: possible prevention by intravenous immunoglobulin. 38
8060816 1994
271
[Platelet transfusion from HPA typed donors in alloimmune thrombocytopenia of newborns and fetuses]. 38
7992593 1994
272
[Immunization against a new, infrequent alloantigen (Iy) on the platelet glycoprotein Ib/IX as a cause of a serious case of neonatal alloimmune thrombocytopenia]. 38
9480101 1994
273
[Molecular biologic clarification of Br alloantigens in human platelets and its application in DNA typing]. 38
9480092 1994
274
Management of fetal and neonatal alloimmune thrombocytopenia. 38
7975518 1994
275
Neonatal Immune Thrombocytopenia Due to Allo-or Autoantibodies: Clinical and Immunological Analysis of 83 Cases. 38
21043744 1994
276
[Anti Ko(a) as a cause of neonatal alloimmune thrombocytopenia]. 38
9480100 1994
277
Prediction of neonatal alloimmune thrombocytopenia using PCR. 38
8165025 1994
278
Prenatal diagnosis of neonatal alloimmune thrombocytopenia using an allele-specific oligonucleotide probe. 38
8140066 1993
279
[Unexpected thrombocytopenia in newborn infants]. 38
8211016 1993
280
[Fetal and neonatal alloimmune thrombocytopenia]. 38
8211017 1993
281
Fetal and neonatal alloimmune thrombocytopenia: current trends in diagnosis and therapy. 38
1339580 1992
282
Anti-HPA-4b (anti-Yuk(a)) neonatal alloimmune thrombocytopenia: first report in a Caucasian family. 38
1339581 1992
283
Neonatal alloimmune thrombocytopenia due to anti-P1A1 (anti-HPA-1a): importance of paternal and fetal platelet typing for assessment of fetal risk. 38
1494549 1992
284
Platelets as immunogens. 38
1450332 1992
285
[Alloimmune neonatal thrombocytopenia]. 38
1594824 1992
286
HPA-5b (Br(a)) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 cases. 38
1873226 1991
287
Sra, a private platelet antigen on glycoprotein IIIa associated with neonatal alloimmune thrombocytopenia. 38
2257303 1990
288
Neonatal alloimmune thrombocytopenia caused by an antibody to the Bak(a) antigen. 38
2091003 1990
289
[Sr(a), a "private" thrombocyte alloantigen as a cause of neonatal alloimmune thrombocytopenia]. 38
1703881 1990
290
[219 Zw(a) positive mothers of children with clinically suspected neonatal alloimmune thrombocytopenia]. 38
1703883 1990
291
[The Br(a)/Br(b) alloantigen system in thrombocytes]. 38
1703880 1990
292
Neonatal alloimmune thrombocytopenia. 38
2676035 1989
293
The Bra/Brb alloantigen system on human platelets. 38
2471562 1989
294
Immunochemical characterization of the new platelet alloantigen system Bra/Brb. 38
2757965 1989
295
Management of alloimmune thrombocytopenia: antenatal diagnosis and in utero transfusion of maternal platelets. 38
3390610 1988
296
The in utero diagnosis and management of alloimmune thrombocytopenia. 38
3405971 1988
297
Immunogenicity of and immune response to the human platelet antigen Zwa is strongly associated with HLA-B8 and DR3. 38
3929422 1985

Variations for Fetal and Neonatal Alloimmune Thrombocytopenia

ClinVar genetic disease variations for Fetal and Neonatal Alloimmune Thrombocytopenia:

6 (showing 1, show less)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 ITGB3 NM_000212.2(ITGB3): c.1373A> G (p.Asp458Gly) single nucleotide variant association rs1555572829 17:45369617-45369617 17:47292251-47292251

Expression for Fetal and Neonatal Alloimmune Thrombocytopenia

Search GEO for disease gene expression data for Fetal and Neonatal Alloimmune Thrombocytopenia.

Pathways for Fetal and Neonatal Alloimmune Thrombocytopenia

Pathways related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(showing 36, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 ITGB3 ITGA2B ITGA2 GP1BB GP1BA CD109
2
Show member pathways
12.73 ITGB3 ITGA2B ITGA2 HLA-DRB3
3
Show member pathways
12.55 ITGB3 ITGA2B ITGA2
4
Show member pathways
12.54 ITGB3 ITGA2B ITGA2
5
Show member pathways
12.49 ITGB3 ITGA2B ITGA2
6 12.39 ITGB3 ITGA2B ITGA2
7
Show member pathways
12.13 ITGB3 ITGA2B ITGA2
8
Show member pathways
12 ITGB3 ITGA2B ITGA2
9
Show member pathways
11.98 ITGB3 ITGA2B ITGA2
10
Show member pathways
11.97 ITGB3 ITGA2B ITGA2
11 11.91 ITGB3 ITGA2 HLA-DRB3
12 11.9 ITGB3 ITGA2B ITGA2
13
Show member pathways
11.78 ITGB3 ITGA2B ITGA2
14 11.77 ITGB3 ITGA2B ITGA2 GP1BA
15
Show member pathways
11.75 ITGB3 ITGA2B ITGA2 GP1BB GP1BA
16 11.72 ITGB3 ITGA2B ITGA2
17
Show member pathways
11.66 ITGB3 ITGA2B GP1BB GP1BA
18 11.63 ITGA2B ITGA2
19 11.58 ITGB3 ITGA2B ITGA2
20 11.5 ITGB3 ITGA2B ITGA2
21 11.45 ITGB3 ITGA2B ITGA2 GP1BB GP1BA
22 11.39 ITGB3 ITGA2B ITGA2
23 11.38 ITGB3 ITGA2B ITGA2
24 11.35 ITGB3 ITGA2B
25 11.32 ITGB3 ITGA2B
26 11.3 ITGB3 ITGA2B ITGA2
27 11.27 ITGB3 ITGA2B ITGA2 GP1BB
28 11.23 ITGB3 ITGA2
29 11.18 ITGA2B ITGA2
30 11.17 ITGB3 ITGA2B ITGA2
31 11.15 ITGB3 ITGA2B
32 11.09 ITGB3 ITGA2B ITGA2 HLA-DRB3 GP1BB GP1BA
33 11.03 ITGB3 ITGA2B
34 10.91 ITGB3 ITGA2B
35 10.61 ITGA2 GP1BB GP1BA
36 10.49 GP1BB GP1BA

GO Terms for Fetal and Neonatal Alloimmune Thrombocytopenia

Cellular components related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(showing 7, show less)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.95 ITGB3 ITGA2B ITGA2 HLA-DRB3 GP1BB GP1BA
2 plasma membrane GO:0005886 9.8 ITGB3 ITGA2B ITGA2 HLA-DRB3 GP1BB GP1BA
3 integral component of plasma membrane GO:0005887 9.67 ITGB3 HLA-DRB3 GP1BB GP1BA
4 cell surface GO:0009986 9.55 ITGB3 ITGA2B ITGA2 GP1BA CD109
5 focal adhesion GO:0005925 9.5 ITGB3 ITGA2B ITGA2
6 integrin complex GO:0008305 9.13 ITGB3 ITGA2B ITGA2
7 platelet alpha granule membrane GO:0031092 8.8 ITGB3 ITGA2B CD109

Biological processes related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(showing 17, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.7 ITGB3 ITGA2B ITGA2
2 platelet degranulation GO:0002576 9.58 ITGB3 ITGA2B CD109
3 wound healing GO:0042060 9.57 ITGB3 ITGA2
4 viral entry into host cell GO:0046718 9.56 ITGB3 ITGA2
5 regulation of megakaryocyte differentiation GO:0045652 9.55 ITGA2B GP1BA
6 hemostasis GO:0007599 9.54 GP1BB GP1BA
7 platelet activation GO:0030168 9.54 ITGB3 GP1BB GP1BA
8 cell adhesion mediated by integrin GO:0033627 9.51 ITGB3 ITGA2
9 integrin-mediated signaling pathway GO:0007229 9.5 ITGB3 ITGA2B ITGA2
10 cell-substrate adhesion GO:0031589 9.49 ITGB3 ITGA2
11 blood coagulation, intrinsic pathway GO:0007597 9.48 GP1BB GP1BA
12 positive regulation of leukocyte migration GO:0002687 9.46 ITGA2B ITGA2
13 mesodermal cell differentiation GO:0048333 9.43 ITGB3 ITGA2
14 cell-matrix adhesion GO:0007160 9.43 ITGB3 ITGA2B ITGA2
15 cell adhesion GO:0007155 9.35 ITGB3 ITGA2B ITGA2 GP1BB GP1BA
16 platelet aggregation GO:0070527 9.33 ITGB3 ITGA2B GP1BA
17 blood coagulation GO:0007596 8.92 ITGB3 ITGA2 GP1BB GP1BA

Molecular functions related to Fetal and Neonatal Alloimmune Thrombocytopenia according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.16 ITGB3 ITGA2
2 extracellular matrix binding GO:0050840 8.96 ITGB3 ITGA2B
3 fibrinogen binding GO:0070051 8.62 ITGB3 ITGA2B

Sources for Fetal and Neonatal Alloimmune Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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