FACS
MCID: FTL073
MIFTS: 23

Fetal Anticonvulsant Syndrome (FACS)

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Fetal Anticonvulsant Syndrome

MalaCards integrated aliases for Fetal Anticonvulsant Syndrome:

Name: Fetal Anticonvulsant Syndrome 58
Fetal Antiepileptic Drug Syndrome 58
Fetal Aeds 58
Facs 58

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis
Teratologic disorders


External Ids:

ICD10 via Orphanet 33 Q86.8
UMLS via Orphanet 72 C1739111
Orphanet 58 ORPHA370068

Summaries for Fetal Anticonvulsant Syndrome

MalaCards based summary : Fetal Anticonvulsant Syndrome, also known as fetal antiepileptic drug syndrome, is related to colorectal cancer and valproate embryopathy. An important gene associated with Fetal Anticonvulsant Syndrome is MTHFR (Methylenetetrahydrofolate Reductase). The drugs Docetaxel and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and prostate.

Related Diseases for Fetal Anticonvulsant Syndrome

Diseases related to Fetal Anticonvulsant Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 colorectal cancer 10.1
2 valproate embryopathy 10.1
3 epicanthus 9.9
4 neural tube defects 9.9
5 strabismus 9.9
6 astigmatism 9.9
7 asperger syndrome 9.9
8 autism spectrum disorder 9.9
9 suppression amblyopia 9.9
10 amblyopia 9.9
11 ametropic amblyopia 9.9
12 myopia 9.9
13 anisometropia 9.9
14 mechanical strabismus 9.9
15 color vision deficiency 9.9
16 leukemia, chronic lymphocytic 2 9.9
17 leukemia, chronic lymphocytic 9.9
18 leukemia, acute myeloid 9.9
19 dengue disease 9.9
20 leukemia 9.9
21 ischemia 9.9
22 embryonal carcinoma 9.9
23 pancreatic ductal adenocarcinoma 9.9
24 myeloid leukemia 9.9
25 alzheimer disease 9.8
26 amyotrophic lateral sclerosis 1 9.8
27 aniridia 1 9.8
28 autoimmune disease 9.8
29 hair whorl 9.8
30 huntington disease 9.8
31 obsessive-compulsive disorder 9.8
32 ovarian cancer 9.8
33 schizophrenia 9.8
34 triiodothyronine receptor auxiliary protein 9.8
35 wilms tumor 1 9.8
36 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
37 osteogenic sarcoma 9.8
38 paine syndrome 9.8
39 aging 9.8
40 macular degeneration, age-related, 1 9.8
41 aplastic anemia 9.8
42 myelodysplastic syndrome 9.8
43 dengue virus 9.8
44 graft-versus-host disease 9.8
45 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.8
46 autoimmune uveitis 9.8
47 cutaneous lupus erythematosus 9.8
48 limb ischemia 9.8
49 autosomal recessive cerebellar ataxia 9.8
50 ductal carcinoma in situ 9.8

Graphical network of the top 20 diseases related to Fetal Anticonvulsant Syndrome:



Diseases related to Fetal Anticonvulsant Syndrome

Symptoms & Phenotypes for Fetal Anticonvulsant Syndrome

Drugs & Therapeutics for Fetal Anticonvulsant Syndrome

Drugs for Fetal Anticonvulsant Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
2
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
3 taxane Phase 3
4 Triamcinolone hexacetonide Phase 3
5 triamcinolone acetonide Phase 3
6 Triamcinolone diacetate Phase 3
7
Fulvestrant Approved, Investigational Phase 1, Phase 2 129453-61-8 104741 17756771
8
Cladribine Approved, Investigational Phase 2 4291-63-8 20279
9
rituximab Approved Phase 2 174722-31-7 10201696
10
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
11
Metronidazole Approved Phase 2 443-48-1 4173
12
Glycerol Approved, Investigational Phase 2 56-81-5 753
13
Bisacodyl Approved Phase 2 603-50-9
14
Vancomycin Approved Phase 2 1404-90-6 441141 14969
15
Loperamide Approved Phase 2 53179-11-6 3955
16 Hormones Phase 1, Phase 2
17 Estrogen Antagonists Phase 1, Phase 2
18 Estrogen Receptor Antagonists Phase 1, Phase 2
19 Hormone Antagonists Phase 1, Phase 2
20 Antineoplastic Agents, Hormonal Phase 1, Phase 2
21 Anti-Infective Agents Phase 2
22 Pharmaceutical Solutions Phase 2
23 Cola Phase 2
24 Immunoglobulins Phase 2
25 Antibodies Phase 2
26
Fluocinolone Acetonide Approved, Investigational, Vet_approved 67-73-2 6215
27
Heparin Approved, Investigational 9005-49-6 772 9812414
28
Atezolizumab Approved, Investigational 1380723-44-3
29
Nitroprusside Approved, Investigational 15078-28-1 11963622
30
Oxymetazoline Approved, Investigational 1491-59-4 4636
31
Phenylephrine Approved 59-42-7 6041
32 Anti-Inflammatory Agents
33 glucocorticoids
34 calcium heparin
35 Immunoglobulin A
36 Anticoagulants
37 adrenomedullin
38 Cystatins
39 Natriuretic Peptide, Brain
40 Angiogenesis Inducing Agents
41 Liver Extracts
42 cyclo(Trp-Asp-Pro-Val-Leu)

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Multicenter Randomized Phase III Trial to Compare 6 FAC Cycles vs 4 FAC Cycles Followed by 8 Weekly Paclitaxel Administrations, as Adjuvant Treatment for Node Negative Operable Breast Cancer Patients Completed NCT00129389 Phase 3 Fluorouracil;Doxorubicin;Cyclophosphamide;Paclitaxel
2 Randomized Clinical Trial to Evaluate the Predictive Accuracy of a Gene Expression Profile-Based Test to Select Patients for Preoperative Taxane/Anthracycline Chemotherapy for Stage I-III Breast Cancer Completed NCT00336791 Phase 3 5-Fluorouracil;Cyclophosphamide;Doxorubicin;Paclitaxel;Epirubicin
3 A Phase 3 Multicenter, Multinational, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ALN TTRSC in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC) Completed NCT02319005 Phase 3 Revusiran (ALN-TTRSC);Sterile Normal Saline (0.9% NaCl)
4 A Multicenter Phase III Randomized Trial Comparing Docetaxel in Combination With Doxorubicin and Cyclophosphamide (TAC) Versus 5-fluorouracil in Combination With Doxorubicin and Cyclophosphamide (FAC) as Adjuvant Treatment of Operable Breast Cancer Patients With Positive Axillary Lymph Nodes. Completed NCT00688740 Phase 3 Docetaxel;5-fluorouracil;Doxorubicin;Cyclophosphamide
5 Phase III Randomized Comparing Docetaxel, Doxorubicin and Cyclophosphamide (TAC) vs 5-Fluorouracil, Doxorubicin and Cyclophosphamide (FAC) as Adjuvant Treatment of High Risk Operable Breast Cancer Patients With Negative Axillary Lymph Nodes Completed NCT00121992 Phase 3 Docetaxel;5-fluorouracil;Doxorubicin;Cyclophosphamide
6 HLA-DQ2-gliadin Tetramer for Diagnosis of Celiac Disease Completed NCT01100099 Phase 2, Phase 3
7 A Randomized Phase II Neoadjuvant Study of Sequential Eribulin Followed by FAC/FEC-regimen Compared to Sequential Paclitaxel Followed by FAC/FEC-Regimen in Women With Early Stage Breast Cancer Not Overexpressing HER-2 Completed NCT01593020 Phase 2 Paclitaxel;Eribulin;5-Fluorouracil;Epirubicin;Cyclophosphamide;Doxorubicin
8 A Phase 2, Randomized, Placebo-controlled, Dose-ranging Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AG10 in Patients With Symptomatic Transthyretin Amyloid Cardiomyopathy Completed NCT03458130 Phase 2 AG10;Placebo Oral Tablet
9 A Randomized Phase I/II Trial of Fulvestrant and Abemaciclib in Combination With Copanlisib (FAC) Versus Fulvestrant and Abemaciclib Alone (FA) for Endocrine-Resistant, Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer (FAC vs FA) Recruiting NCT03939897 Phase 1, Phase 2 Abemaciclib;Copanlisib Hydrochloride;Fulvestrant
10 Randomized Trial of Cladribine (CdA) With Simultaneous or Delayed Rituximab to Eliminate Hairy Cell Leukemia Minimal Residual Disease Recruiting NCT00923013 Phase 2 Cladribine;Rituximab
11 Open Label Clinical Trial to Evaluate the Efficacy of Fecal Microbiota Transplantation in Patients With Alopecia Areata Not yet recruiting NCT04238091 Phase 2 Fecal material transfer therapy;Pre-FMT Antibiotic Cocktail;Bowel Prep
12 Rapid Structural and Functional Improvements in Following 0.19 mg Fluocinolone Acetonide (FAc) Implant in Diabetic Macular Edema Patients With Poor Visual Acuity: 12-month Audit Results From United Arab Emirates Unknown status NCT03590587 0.19 mg fluocinolone acetonide (FAc) implant
13 A Randomised Controlled Trial to Assess the Cost-effectiveness of Intensive Versus no Scheduled Follow-up in Patients Who Have Undergone Resection for Colorectal Cancer With Curative Intent. (FACS - Follow-up After Colorectal Surgery) Unknown status NCT00560365
14 Early Detection of Prostate Cancer by FACS Unknown status NCT00524823
15 Sub Populations of Immune Cells in Influenza A and B Patients Unknown status NCT03366402
16 Lower Body Positive Pressure Treadmill Training in Post-Stroke Gait Impairment Completed NCT03957785
17 DISCOVERY: A Study Examining the Prevalence of TTR Mutations in Subjects Suspected of Having Cardiac Amyloidosis Completed NCT02252653
18 Family Access to Care Study (FACS) Completed NCT00582218
19 Accuracy Evaluation of the BD FACS Presto System: Instrument, Software and BD CD4/%CD4/Hb Cartridge Assay Completed NCT02396355
20 The Biodistribution of 1-L-(2 Deoxy-2,- 18 Fluoroarabinofuranosyl) Cytosine ([18F]L-FAC) in Healthy Subjects and Patients With Cancer, Autoimmune and Inflammatory Diseases Completed NCT01180868
21 Intradiscal Injection of an Autologous Alpha-2-macroglobulin (A2M) Concentrate Alleviates Back Pain in FAC-positive Patients Completed NCT03307876
22 Acute Cardiovascular Effects of External Counterpulsation (ECP) in Comparison With Physical Exercise in Healthy Individuals Completed NCT02014090
23 Brain Injury Inpatient Educational Intervention for Families and Caregivers (a Research Project Within the Traumatic Brain Injury Model System) Completed NCT01062243
24 Phenotype-genotype Correlation in a Sub-population of Severe Primary Immunodeficiency With Lymphoproliferation and Neutropenia Completed NCT03427593
25 The Circulating Fibrocyte - a Novel and Accurate Biomarker in Diagnosing Acute Appendicitis in Adults Completed NCT03988660
26 Characterization of Immune Responses Against Acne-associated Bacterium Propionibacterium Acnes - a Pilot Study Completed NCT04056598
27 Flow Cytometric Analysis of Peripheral Blood Neutrophil Myeloperoxidase Expression for Ruling Out Myelodysplastic Syndromes: A Pilot Diagnostic Accuracy Study Completed NCT03363399
28 Development of a Digital Solution for Acute Pain Assessment Using Automartized Facial Expression Analysis Completed NCT03957967
29 The Effects of Stroke Related Neurogenic Bladder on The Quality of Life: A Study of Turkish Population Completed NCT04072796
30 Diagnostic and Prognostic Value of Cardiac Biomarkers and Echocardiography for Patients Hospitalized Due to Acute Dyspnea: Prospective Observational Multicenter Cohort Study Completed NCT03048032
31 Validation and Reliability of the Dutch Version of the Fear-Avoidance Component Scale (FACS) Recruiting NCT03994861
32 Register für Schwere Immunzytopenien - Severe Immune Cytopenia Registry (SIC-Reg.Org) Recruiting NCT03576742
33 Analysis of Soluble Mediators, Cytokines, and Circulating Angiogenic Factors (FACs) as Potential Predictors / Prognostic Factors in Antiangiogenic Therapy Following Failure of First-line Chemotherapy in Advanced Non-squamous Lung Carcinoma Active, not recruiting NCT03156868
34 A Study for Identification of Predictive Immune Biomarker for Atezolizumab Therapy in NSCLC Patients Not yet recruiting NCT04312308
35 Role of Regulatory B Cells in the Pathogenesis of Metabolic Associated Fatty Liver Disease Not yet recruiting NCT04720560
36 Resume Walking by an Interactive Mobile Robot of Rehabilitation After Vascular Stroke (Cerebral Vascular Stroke) in Combination With Traditional Reeducation Not yet recruiting NCT03686280
37 Molecular Investigation of Genetic Factors in CArDiovascular Diseases Using an BIOresource of Healthy Volunteers Suspended NCT03038750
38 Molecular Triaging of Newly Diagnosed Breast Cancer for Preoperative Therapies Withdrawn NCT01159236 Paclitaxel;Fluorouracil;Doxorubicin;Epirubicin;Cyclophosphamide;Bevacizumab

Search NIH Clinical Center for Fetal Anticonvulsant Syndrome

Genetic Tests for Fetal Anticonvulsant Syndrome

Anatomical Context for Fetal Anticonvulsant Syndrome

MalaCards organs/tissues related to Fetal Anticonvulsant Syndrome:

40
Brain, Liver, Prostate, B Cells, Neutrophil, Cortex

Publications for Fetal Anticonvulsant Syndrome

Articles related to Fetal Anticonvulsant Syndrome:

(show all 21)
# Title Authors PMID Year
1
Exome sequencing in patients with antiepileptic drug exposure and complex phenotypes. 61
31481360 2020
2
Fetal valproate syndrome: the Irish experience. 61
29396778 2018
3
Development of a core outcome set for epilepsy in pregnancy (E-CORE): a national multi-stakeholder modified Delphi consensus study. 61
27860117 2017
4
Early valproic acid exposure alters functional organization in the primary visual cortex. 61
21215743 2011
5
Intracranial arteriovenous malformation with maternal carbamazepine use. 61
17264463 2007
6
Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes. 61
16239295 2006
7
A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect. 61
16676441 2006
8
Characteristics of fetal anticonvulsant syndrome associated autistic disorder. 61
16108456 2005
9
Using current evidence in selecting antiepileptic drugs for use during pregnancy. 61
16059433 2005
10
Interaction between anticonvulsants and human placental carnitine transporter. 61
15009220 2004
11
The importance of monotherapy in pregnancy. 61
12796519 2003
12
Pregnancy in the woman with epilepsy: maternal and fetal outcomes. 61
12528055 2002
13
Ophthalmic findings in fetal anticonvulsant syndrome(s). 61
11986102 2002
14
A clinical study of 57 children with fetal anticonvulsant syndromes. 61
10882750 2000
15
5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. 61
10791559 2000
16
Developing diagnostic criteria for the fetal anticonvulsant syndromes. 61
10775521 2000
17
Fetal anticonvulsant syndrome and mutation in the maternal MTHFR gene. 61
10563481 1999
18
Fetal anticonvulsant syndrome in rats: effects on postnatal behavior and brain amino acid content. 61
4080065 1985
19
Functional palatal incompetence in the fetal anticonvulsant syndrome. 61
6497436 1984
20
Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. 61
6195326 1983
21
[Pharmacotherapy of epilepsy--current problems and controversies]. 61
6418628 1983

Variations for Fetal Anticonvulsant Syndrome

Expression for Fetal Anticonvulsant Syndrome

Search GEO for disease gene expression data for Fetal Anticonvulsant Syndrome.

Pathways for Fetal Anticonvulsant Syndrome

GO Terms for Fetal Anticonvulsant Syndrome

Sources for Fetal Anticonvulsant Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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