MCID: FTL016
MIFTS: 25

Fetal Edema

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Fetal Edema

MalaCards integrated aliases for Fetal Edema:

Name: Fetal Edema 54
Hydrops Fetalis 74

Classifications:



External Ids:

UMLS 74 C0020305

Summaries for Fetal Edema

MalaCards based summary : Fetal Edema, also known as hydrops fetalis, is related to hydrops fetalis, nonimmune and immune hydrops fetalis, and has symptoms including edema and peau d'orange. The drugs Darbepoetin alfa and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include heart, placenta and lung.

Related Diseases for Fetal Edema

Diseases related to Fetal Edema via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hydrops fetalis, nonimmune 11.4
2 immune hydrops fetalis 11.2
3 costello syndrome 9.7
4 lymphatic malformation 7 9.7
5 hydrops fetalis 9.7

Graphical network of the top 20 diseases related to Fetal Edema:



Diseases related to Fetal Edema

Symptoms & Phenotypes for Fetal Edema

UMLS symptoms related to Fetal Edema:


edema, peau d'orange

Drugs & Therapeutics for Fetal Edema

Drugs for Fetal Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darbepoetin alfa Approved, Investigational Phase 2, Phase 3 209810-58-2, 11096-26-7
2 Hematinics Phase 2, Phase 3
3
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
4 Immunoglobulins Phase 2
5 Antibodies Phase 2
6 Anti-Inflammatory Agents Phase 1, Phase 2
7 Respiratory System Agents Phase 1, Phase 2
8 glucocorticoids Phase 1, Phase 2
9 Betamethasone benzoate Phase 1, Phase 2
10 Anti-Asthmatic Agents Phase 1, Phase 2
11 Betamethasone Valerate Phase 1, Phase 2 2152-44-5
12 Betamethasone-17,21-dipropionate Phase 1, Phase 2
13 Betamethasone sodium phosphate Phase 1, Phase 2
14 Hormones Phase 1, Phase 2
15 Hormone Antagonists Phase 1, Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
17 Anti-Arrhythmia Agents

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 EPO-4-Rhesus Study Recruiting NCT03104426 Phase 2, Phase 3 Darbepoetin Alfa
2 A Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of M281 Administered to Pregnant Women at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn (HDFN) Recruiting NCT03842189 Phase 2 M281
3 Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM) Terminated NCT00670956 Phase 1, Phase 2 Betamethasone;Placebo
4 In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM) Recruiting NCT02986698 Phase 1
5 Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine Treatment Unknown status NCT02956564 Not Applicable
6 Hydrops: Diagnosing & Redefining Outcomes With Precision Study Recruiting NCT03412760 Not Applicable
7 Whole Exome Sequencing and Whole Genome Sequencing for Non-immune Fetal/Neonatal Hydrops Recruiting NCT03911531
8 Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia Recruiting NCT03376438
9 Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise Recruiting NCT03775954
10 A Study to Characterize the Clinical Course of Pregnant Women and Children at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn Recruiting NCT03755128
11 Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGR Terminated NCT00143039

Search NIH Clinical Center for Fetal Edema

Genetic Tests for Fetal Edema

Anatomical Context for Fetal Edema

MalaCards organs/tissues related to Fetal Edema:

42
Heart, Placenta, Lung, Brain, Testes, Kidney, Bone

Publications for Fetal Edema

Articles related to Fetal Edema:

(show top 50) (show all 845)
# Title Authors Year
1
Hemochromatosis associated with cholelithiasis as a cause of hydrops fetalis and stillbirth: Prenatal diagnosis. ( 30378124 )
2019
2
Placental chorioangioma associated with polyhydramnios and hydrops fetalis. ( 30700468 )
2019
3
Fetal-onset congenital dyserythropoietic anemia type 1 due to CDAN1 mutations presenting as hydrops fetalis. ( 30786798 )
2019
4
Pulmonary Artery Banding for Congenitally Corrected Transposition of the Great Arteries With Hydrops Fetalis: A Case Report. ( 31018764 )
2019
5
Fetal edema, not overgrowth, is associated with neonatal lethal Costello syndrome due to the HRAS p.Gly12Val mutation. ( 30664540 )
2019
6
Trisomy 21 and hydrops fetalis: parvovirus B19 or transient abnormal myelopoiesis? ( 30634881 )
2019
7
Biallelic loss of function variants in ATP1A2 cause hydrops fetalis, microcephaly, arthrogryposis and extensive cortical malformations. ( 30690204 )
2019
8
Non-immune hydrops fetalis neonate born to a mother with yellow nail syndrome. ( 30883972 )
2019
9
Hydrops Fetalis and Persistent Pulmonary Hypertension in a Neonate with Anti-E Alloimmunization. ( 30949372 )
2019
10
Exchange Transfusion and Cytarabine for Transient Abnormal Myelopoiesis in Hydrops Fetalis. ( 31015754 )
2019
11
Author Correction: Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. ( 31028252 )
2019
12
A System-Based Approach to the Genetic Etiologies of Non-Immune Hydrops Fetalis. ( 31087399 )
2019
13
Effect of maternal betamethasone on hydrops fetalis caused by extralobar pulmonary sequestration: a case report. ( 29553854 )
2019
14
Outcomes following antenatal identification of hydrops fetalis: a single-centre experience from 2001 to 2012. ( 29769237 )
2019
15
Invasive prenatal diagnosis of α-thalassemia to control Hb Bart's hydrops fetalis syndrome: 15 years of experience. ( 29948167 )
2018
16
Potential new approaches to the management of the Hb Bart's hydrops fetalis syndrome: the most severe form of α-thalassemia. ( 30504332 )
2018
17
Placental Chorioangioma with Nonimmune Hydrops Fetalis. ( 30075468 )
2018
18
Recurring mutations in RPL15 are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia. ( 29599205 )
2018
19
hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. ( 30115739 )
2018
20
Hydrops Fetalis and THE Parvovirus B-19. ( 30124157 )
2018
21
Peripheral Blood Smear of Bart's Hydrops Fetalis. ( 30127576 )
2018
22
Identification of novel PIEZO1 variants using prenatal exome sequencing and correlation to ultrasound and autopsy findings of recurrent hydrops fetalis. ( 30244526 )
2018
23
Nonimmune hydrops fetalis: identifying the underlying genetic etiology. ( 30410095 )
2018
24
A Rare Hb H Hydrops Fetalis Syndrome Caused by the - -SEA Deletion in Combination with the Rare Hb Hirosaki Mutation in a Chinese Patient. ( 30486690 )
2018
25
Deletion of macro domain containing 2(MACRO D2) associated with transient hydrops fetalis. ( 30545550 )
2018
26
Novel mutation in CCBE 1 as a cause of recurrent hydrops fetalis from Hennekam lymphangiectasia-lymphedema syndrome-1. ( 30564329 )
2018
27
Fetal hemoglobin Bart's hydrops fetalis: pathophysiology, prenatal diagnosis and possibility of intrauterine treatment. ( 28277912 )
2018
28
Outcome and Treatment of Antenatally Diagnosed Nonimmune Hydrops Fetalis. ( 28647738 )
2018
29
Inborn errors of metabolism in a cohort of pregnancies with non-immune hydrops fetalis: a single center experience. ( 28822227 )
2018
30
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? ( 29076544 )
2018
31
Fetal Anemia Causing Hydrops Fetalis From an Alpha-Globin Variant: Homozygous Hemoglobin Constant Spring. ( 29240037 )
2018
32
Iron overload in transfusion-dependent survivors of hemoglobin Bart's hydrops fetalis. ( 29371322 )
2018
33
A case of vasculopathy of unknown etiology associated with fatal hydrops fetalis and review of the literature on intimomedial mucoid degeneration. ( 29414431 )
2018
34
Metabolic causes of nonimmune hydrops fetalis: A next-generation sequencing panel as a first-line investigation. ( 29476731 )
2018
35
Mesalazine as a cause of fetal anemia and hydrops fetalis: A case report: Erratum. ( 29480868 )
2018
36
Characterization of Hb Bart's Hydrops Fetalis Caused by - -SEA and a Large Novel α0-Thalassemia Deletion. ( 29493331 )
2018
37
Improved diagnosis in nonimmune hydrops fetalis using a standardized algorithm. ( 29500832 )
2018
38
Thymic teratoma presenting as non-immune hydrops fetalis. ( 29515979 )
2018
39
Outcomes and morbidities of patients who survive haemoglobin Bart's hydrops fetalis syndrome: 20-year retrospective review. ( 29632273 )
2018
40
Biochemical and molecular analyses of infantile sialic acid storage disease in a patient with nonimmune hydrops fetalis. ( 29654786 )
2018
41
Sonographic Demonstration of Intracranial Hemorrhage in a Fetus with Hydrops Fetalis due to Rh Alloimmunization after Intrauterine Intravascular Transfusion: A Case Report and Review of the Literature. ( 29780649 )
2018
42
Perinatal Lethal Gaucher Disease due to RecNcil Recombinant Mutation in the GBA Gene Presenting with Hydrops Fetalis and Severe Congenital Anemia. ( 29854527 )
2018
43
A case of mirror syndrome caused by hydrops fetalis after fetoscopic laser photocoagulation. ( 29881553 )
2018
44
Nonimmune Hydrops Fetalis: Factors Which Predict Outcome. ( 29895999 )
2018
45
A recessive truncating variant in thrombospondin-1 domain containing protein 1 gene THSD1 is the underlying cause of nonimmune hydrops fetalis, congenital cardiac defects, and haemangiomas in four patients from a consanguineous family. ( 30055085 )
2018
46
Non-immune hydrops fetalis: A retrospective analysis of 151 autopsies performed at a single center. ( 30968631 )
2018
47
Alpha-thalassemia major and restrictive foramen ovale in a preterm neonate without severe hydrops fetalis. ( 28381365 )
2017
48
Resolution of hydrops fetalis caused by atrioventricular block: good postnatal evolution with terbutaline treatment. ( 29714889 )
2017
49
Kaposiform Hemangioendothelioma Presenting as Hydrops Fetalis. ( 28318049 )
2017
50
Nonimmune hydrops fetalis due to autosomal recessive hereditary spherocytosis. ( 29594000 )
2017

Variations for Fetal Edema

Expression for Fetal Edema

Search GEO for disease gene expression data for Fetal Edema.

Pathways for Fetal Edema

GO Terms for Fetal Edema

Sources for Fetal Edema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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