MCID: FTL016
MIFTS: 25

Fetal Edema

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Fetal Edema

MalaCards integrated aliases for Fetal Edema:

Name: Fetal Edema 54
Hydrops Fetalis 74

Classifications:



External Ids:

UMLS 74 C0020305

Summaries for Fetal Edema

MalaCards based summary : Fetal Edema, also known as hydrops fetalis, is related to hydrops fetalis, nonimmune and immune hydrops fetalis, and has symptoms including edema and peau d'orange. The drugs Darbepoetin alfa and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include heart, placenta and lung.

Related Diseases for Fetal Edema

Diseases related to Fetal Edema via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hydrops fetalis, nonimmune 11.3
2 immune hydrops fetalis 11.2
3 costello syndrome 9.7
4 lymphatic malformation 7 9.7
5 hydrops fetalis 9.7

Graphical network of the top 20 diseases related to Fetal Edema:



Diseases related to Fetal Edema

Symptoms & Phenotypes for Fetal Edema

UMLS symptoms related to Fetal Edema:


edema, peau d'orange

Drugs & Therapeutics for Fetal Edema

Drugs for Fetal Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darbepoetin alfa Approved, Investigational Phase 2, Phase 3 11096-26-7, 209810-58-2
2 Hematinics Phase 2, Phase 3
3
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
4 Immunoglobulins Phase 2
5 Antibodies Phase 2
6 Betamethasone Valerate Phase 1, Phase 2 2152-44-5
7 Hormone Antagonists Phase 1, Phase 2
8 Respiratory System Agents Phase 1, Phase 2
9 glucocorticoids Phase 1, Phase 2
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
11 Anti-Inflammatory Agents Phase 1, Phase 2
12 Betamethasone-17,21-dipropionate Phase 1, Phase 2
13 Hormones Phase 1, Phase 2
14 Anti-Asthmatic Agents Phase 1, Phase 2
15 Betamethasone sodium phosphate Phase 1, Phase 2
16 Betamethasone benzoate Phase 1, Phase 2
17 Anti-Arrhythmia Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 EPO-4-Rhesus Study Recruiting NCT03104426 Phase 2, Phase 3 Darbepoetin Alfa
2 A Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of M281 Administered to Pregnant Women at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn (HDFN) Not yet recruiting NCT03842189 Phase 2 M281
3 Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM) Terminated NCT00670956 Phase 1, Phase 2 Betamethasone;Placebo
4 In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM) Recruiting NCT02986698 Phase 1
5 Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine Treatment Unknown status NCT02956564 Not Applicable
6 Fetal Birth Defects: Toward a Precision-based Approach Recruiting NCT03412760 Not Applicable
7 Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia Recruiting NCT03376438
8 Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise Recruiting NCT03775954
9 A Study to Characterize the Clinical Course of Pregnant Women and Children at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn Recruiting NCT03755128
10 Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGR Terminated NCT00143039

Search NIH Clinical Center for Fetal Edema

Genetic Tests for Fetal Edema

Anatomical Context for Fetal Edema

MalaCards organs/tissues related to Fetal Edema:

42
Heart, Placenta, Lung, Brain, Testes, Kidney, Bone

Publications for Fetal Edema

Articles related to Fetal Edema:

(show top 50) (show all 840)
# Title Authors Year
1
Placental chorioangioma associated with polyhydramnios and hydrops fetalis. ( 30700468 )
2019
2
Fetal-onset congenital dyserythropoietic anemia type 1 due to CDAN1 mutations presenting as hydrops fetalis. ( 30786798 )
2019
3
Fetal edema, not overgrowth, is associated with neonatal lethal Costello syndrome due to the HRAS p.Gly12Val mutation. ( 30664540 )
2019
4
Trisomy 21 and hydrops fetalis: parvovirus B19 or transient abnormal myelopoiesis? ( 30634881 )
2019
5
Biallelic loss of function variants in ATP1A2 cause hydrops fetalis, microcephaly, arthrogryposis and extensive cortical malformations. ( 30690204 )
2019
6
Non-immune hydrops fetalis neonate born to a mother with yellow nail syndrome. ( 30883972 )
2019
7
Outcomes following antenatal identification of hydrops fetalis: a single-centre experience from 2001 to 2012. ( 29769237 )
2018
8
A case of vasculopathy of unknown etiology associated with fatal hydrops fetalis and review of the literature on intimomedial mucoid degeneration. ( 29414431 )
2018
9
Improved diagnosis in nonimmune hydrops fetalis using a standardized algorithm. ( 29500832 )
2018
10
Thymic teratoma presenting as non-immune hydrops fetalis. ( 29515979 )
2018
11
Mesalazine as a cause of fetal anemia and hydrops fetalis: A case report: Erratum. ( 29480868 )
2018
12
Nonimmune Hydrops Fetalis: Factors Which Predict Outcome. ( 29895999 )
2018
13
Recurring mutations in <i>RPL15</i> are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia. ( 29599205 )
2018
14
Iron overload in transfusion-dependent survivors of hemoglobin Bart's hydrops fetalis. ( 29371322 )
2018
15
Characterization of Hb Bart's Hydrops Fetalis Caused by -a88-<sup>SEA</sup> and a Large Novel I+<sup>0</sup>-Thalassemia Deletion. ( 29493331 )
2018
16
Biochemical and molecular analyses of infantile sialic acid storage disease in a patient with nonimmune hydrops fetalis. ( 29654786 )
2018
17
Perinatal Lethal Gaucher Disease due to RecNcil Recombinant Mutation in the <i>GBA</i> Gene Presenting with Hydrops Fetalis and Severe Congenital Anemia. ( 29854527 )
2018
18
A case of mirror syndrome caused by hydrops fetalis after fetoscopic laser photocoagulation. ( 29881553 )
2018
19
Sonographic Demonstration of Intracranial Hemorrhage in a Fetus with Hydrops Fetalis due to Rh Alloimmunization after Intrauterine Intravascular Transfusion: A Case Report and Review of the Literature. ( 29780649 )
2018
20
Invasive prenatal diagnosis of I+-thalassemia to control Hb Bart's hydrops fetalis syndrome: 15A years of experience. ( 29948167 )
2018
21
Outcomes and morbidities of patients who survive haemoglobin Bart's hydrops fetalis syndrome: 20-year retrospective review. ( 29632273 )
2018
22
Effect of maternal betamethasone on hydrops fetalis caused by extralobar pulmonary sequestration: a case report. ( 29553854 )
2018
23
Metabolic causes of nonimmune hydrops fetalis: A next-generation sequencing panel as a first-line investigation. ( 29476731 )
2018
24
Potential new approaches to the management of the Hb Bart's hydrops fetalis syndrome: the most severe form of α-thalassemia. ( 30504332 )
2018
25
Hemochromatosis associated with cholelithiasis as a cause of hydrops fetalis and stillbirth: Prenatal diagnosis. ( 30378124 )
2018
26
Placental Chorioangioma with Nonimmune Hydrops Fetalis. ( 30075468 )
2018
27
A recessive truncating variant in thrombospondin-1 domain containing protein 1 gene THSD1 is the underlying cause of nonimmune hydrops fetalis, congenital cardiac defects, and haemangiomas in four patients from a consanguineous family. ( 30055085 )
2018
28
hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. ( 30115739 )
2018
29
Hydrops Fetalis And The Parvovirus B-19. ( 30124157 )
2018
30
Peripheral Blood Smear of Bart's Hydrops Fetalis. ( 30127576 )
2018
31
Identification of novel PIEZO1 variants using prenatal exome sequencing and correlation to ultrasound and autopsy findings of recurrent hydrops fetalis. ( 30244526 )
2018
32
Nonimmune hydrops fetalis: identifying the underlying genetic etiology. ( 30410095 )
2018
33
A Rare Hb H Hydrops Fetalis Syndrome Caused by the - -SEA Deletion in Combination with the Rare Hb Hirosaki Mutation in a Chinese Patient. ( 30486690 )
2018
34
Deletion of macro domain containing 2(MACRO D2) associated with transient hydrops fetalis. ( 30545550 )
2018
35
Novel mutation in CCBE 1 as a cause of recurrent hydrops fetalis from Hennekam lymphangiectasia-lymphedema syndrome-1. ( 30564329 )
2018
36
Fetal Thoracoamniotic Shunting in a Case of Congenital Pulmonary Airway Malformations with Hydrops Fetalis. ( 28948063 )
2017
37
Interstitial deletion of chromosome 1 (1p21.1p12) in an infant with congenital diaphragmatic hernia, hydrops fetalis, and interrupted aortic arch. ( 28174644 )
2017
38
Fetal hemoglobin Bart's hydrops fetalis: pathophysiology, prenatal diagnosis and possibility of intrauterine treatment. ( 28277912 )
2017
39
Inborn errors of metabolism in a cohort of pregnancies with non-immune hydrops fetalis: a single center experience. ( 28822227 )
2017
40
A 6-year-old girl diagnosed with mevalonate kinase deficiency who had hydrops fetalis and neonatal-onset cholestasis. ( 28603204 )
2017
41
Genetic origin of I+(0)-thalassemia (SEA deletion) in Southeast Asian populations and application to accurate prenatal diagnosis of Hb Bart's hydrops fetalis syndrome. ( 28381876 )
2017
42
Alpha-Thalassemia Major and Restrictive Foramen Ovale in a Preterm Neonate Without Severe Hydrops Fetalis. ( 28381365 )
2017
43
Nonimmune hydrops fetalis due to autosomal recessive hereditary spherocytosis. ( 29594000 )
2017
44
Prognostic factors of hydrops fetalis with pleural effusion. ( 28672054 )
2017
45
Pulmonary Neuroendocrine Cell Hyperplasia in Hemoglobin Bart-induced Hydrops Fetalis: A model for Chronic Intrauterine Hypoxia. ( 28727978 )
2017
46
Compound heterozygous GATA5 mutations in a girl with hydrops fetalis, congenital heart defects and genital anomalies. ( 28180938 )
2017
47
Fetal Anemia Causing Hydrops Fetalis From an Alpha-Globin Variant: Homozygous Hemoglobin Constant Spring. ( 29240037 )
2017
48
An international registry of survivors with Hb Bart's Hydrops Fetalis Syndrome. ( 28057638 )
2017
49
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? ( 29076544 )
2017
50
Mesalazine as a cause of fetal anemia and hydrops fetalis: A case report. ( 29390381 )
2017

Variations for Fetal Edema

Expression for Fetal Edema

Search GEO for disease gene expression data for Fetal Edema.

Pathways for Fetal Edema

GO Terms for Fetal Edema

Sources for Fetal Edema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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