MCID: FTL016
MIFTS: 24

Fetal Edema

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Fetal Edema

MalaCards integrated aliases for Fetal Edema:

Name: Fetal Edema 53
Hydrops Fetalis 72

Classifications:



External Ids:

UMLS 72 C0020305

Summaries for Fetal Edema

MalaCards based summary : Fetal Edema, also known as hydrops fetalis, is related to hydrops fetalis, nonimmune and immune hydrops fetalis, and has symptoms including edema and peau d'orange. The drugs Ibuprofen and Darbepoetin alfa have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and placenta.

Related Diseases for Fetal Edema

Diseases related to Fetal Edema via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hydrops fetalis, nonimmune 11.5
2 immune hydrops fetalis 11.3
3 hydrops, lactic acidosis, and sideroblastic anemia 10.1
4 hydrops fetalis 9.8
5 fetal akinesia deformation sequence 1 9.7
6 costello syndrome 9.7
7 polydactyly 9.7
8 aortic coarctation 9.7
9 overgrowth syndrome 9.7

Graphical network of the top 20 diseases related to Fetal Edema:



Diseases related to Fetal Edema

Symptoms & Phenotypes for Fetal Edema

UMLS symptoms related to Fetal Edema:


edema, peau d'orange

Drugs & Therapeutics for Fetal Edema

Drugs for Fetal Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
2
Darbepoetin alfa Approved, Investigational Phase 2, Phase 3 11096-26-7, 209810-58-2
3 Analgesics Phase 2, Phase 3
4 Analgesics, Non-Narcotic Phase 2, Phase 3
5 Cyclooxygenase Inhibitors Phase 2, Phase 3
6 Peripheral Nervous System Agents Phase 2, Phase 3
7 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
8 Anti-Inflammatory Agents Phase 2, Phase 3
9 Antirheumatic Agents Phase 2, Phase 3
10 Hematinics Phase 2, Phase 3
11
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
12 Hormones Phase 1
13 Calcium, Dietary Phase 1
14 Bone Density Conservation Agents Phase 1
15
Ferrous fumarate Approved 141-01-5
16
Imidacloprid Vet_approved 105827-78-9 86418
17 interferons
18 Interferon-gamma
19 Anti-Arrhythmia Agents
20 Nutrients
21 Micronutrients
22 Trace Elements

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 High-dose Ibuprofen for Patent Ductus Arteriosus in Extremely Preterm Infants: a Randomized Controlled Study Completed NCT01243996 Phase 2, Phase 3 Ibuprofen
2 Randomized Controlled Trial on the Use of EPO to Reduce Top-up Transfusions in Neonates With Red Blood Cell Alloimmunization Treated With Intrauterine Transfusions Recruiting NCT03104426 Phase 2, Phase 3 Darbepoetin Alfa
3 Prevention of Myopia of Prematurity by Calcium Supplementation in a Randomized Controlled Pilot Trial Completed NCT00892476 Phase 1
4 A Single-Center, Non-Randomized Study of the Safety and Efficacy of In Utero Hematopoietic Stem Cell Transplantation for the Treatment of Fetuses With Alpha Thalassemia Major Recruiting NCT02986698 Phase 1
5 Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine Treatment Unknown status NCT02956564
6 Enhanced HCV Nonstructural Protein 3 (NS3) -Specific T Cell Proliferation,Interferon γ (IFNγ) and Interleukin-10 (IL-10) Secreting Clones, and Peripheral Blood Natural Killers T Cells ( NKT Cells) in Patients With Type I Gaucher Disease Infected With HCV : An Advantage in Anti Hepatitis Immunity? Unknown status NCT01274208
7 Estimation of Umbilical Venous Catheter Insertion Depth in Newborns Using Weight or Body Measurement: A Randomized Trial Completed NCT02939690
8 Identification of Early Predictors of Fetomaternal Hemorrhage And Development Of An Automated Screening Strategy For At-Risk Pregnancies Completed NCT01232387
9 Hydrops: Diagnosing & Redefining Outcomes With Precision Study Recruiting NCT03412760
10 Whole Exome Sequencing and Whole Genome Sequencing for Non-immune Fetal/Neonatal Hydrops Recruiting NCT03911531
11 FAST Trial Registry: Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia Recruiting NCT03376438
12 Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise Recruiting NCT03775954
13 Biomarker for Gangliosidosis: BioGM1 / BioGM2 AN INTERNATIONAL, MULTICENTER, EPIDEMIOLOGICAL PROTOCOL Recruiting NCT02298647
14 Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by Nonimmune Hydrops and Severe Symmetrical Intrauterine Growth Restriction-A Multicenter Prospective Pilot Cohort Study Terminated NCT00143039

Search NIH Clinical Center for Fetal Edema

Genetic Tests for Fetal Edema

Anatomical Context for Fetal Edema

MalaCards organs/tissues related to Fetal Edema:

41
Heart, Lung, Placenta, Testes, Bone, Liver, Brain

Publications for Fetal Edema

Articles related to Fetal Edema:

(show top 50) (show all 2210)
# Title Authors PMID Year
1
A system-based approach to the genetic etiologies of non-immune hydrops fetalis. 38
31087399 2019
2
Non-Immune Hydrops Fetalis and Congenital Disorders of Glycosylation: A Systematic Literature Review. 38
31420886 2019
3
Congenital Hemolytic Anemia Because of Glucose Phosphate Isomerase Deficiency: Identification of 2 Novel Missense Mutations in the GPI Gene. 38
31415279 2019
4
Congenital Cystic Adenomatoid Malformation Volume Ratio in Prenatal Assessment of Prognosis of Fetal Pulmonary Sequestrations. 38
31347005 2019
5
Noninvasive Prenatal Detection of Hemoglobin Bart hydrops fetalis via maternal plasma dispensed with parental haplotyping using the Semiconductor Sequencing Platform (SSP). 38
31394068 2019
6
Newborn with hydrops fetalis and a severe supraventricular arrhythmia. 38
31434639 2019
7
Management of patients with rare blood groups in maternity. 38
31368389 2019
8
Characterization of deletional and non-deletional alpha globin variants in a large cohort from Spain between 2009 and 2014. 38
31025160 2019
9
Gene expression in blood from an individual with β-thalassemia: An RNA sequence analysis. 38
31134759 2019
10
Etiology and Outcome of non-immune Hydrops Fetalis in Southern China: report of 1004 cases. 38
31341179 2019
11
A case report of Turner syndrome associated with fetal nuchal cystic hygroma and bilateral syndactyly of the hands and feet. 38
31319890 2019
12
Analysis of cystic hygroma diagnosed in the first trimester: single-center experience 38
31298510 2019
13
Nonimmune hydrops fetalis: identifying the underlying genetic etiology. 38
30410095 2019
14
Diamond-Blackfan anemia RPL35A: a case report. 38
31208452 2019
15
Case Report of Anemia Following Fetal-Maternal Hemorrhage. 38
30969944 2019
16
Association between mucopolysaccharidosis Type VII and hydrops fetalis. 38
31180609 2019
17
Molecular characteristics of thalassemia and hemoglobin variants in prenatal diagnosis program in northern Thailand. 38
31240559 2019
18
Foetal right atrial aneurysm and aortic coarctation with left ventricular dysfunction. 38
31221232 2019
19
Prevalence and risk factors for hearing loss in high-risk neonates in Germany. 38
31074050 2019
20
Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence. 38
31136762 2019
21
Molecular autopsy by trio exome sequencing (ES) and postmortem examination in fetuses and neonates with prenatally identified structural anomalies. 38
30293990 2019
22
Trisomy 21 and hydrops fetalis: parvovirus B19 or transient abnormal myelopoiesis? 38
30634881 2019
23
Structure of Parvovirus B19 Decorated by Fabs from a Human Antibody. 38
30787153 2019
24
Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia. 38
31120421 2019
25
Outcomes following antenatal identification of hydrops fetalis: a single-centre experience from 2001 to 2012. 38
29769237 2019
26
Exchange Transfusion and Cytarabine for Transient Abnormal Myelopoiesis in Hydrops Fetalis. 38
31015754 2019
27
Congenital Lung Malformations. 38
30986318 2019
28
Author Correction: Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. 38
31028252 2019
29
Fetal edema, not overgrowth, is associated with neonatal lethal Costello syndrome due to the HRAS p.Gly12Val mutation. 38
30664540 2019
30
Anemic Disease of the Newborn With Little Increase in Hemolysis and Erythropoiesis Due to Maternal Anti-Jra: A Case Study and Review of the Literature. 38
31227265 2019
31
Severe anti-D haemolytic disease of fetal and newborn in rhesus D negative primigravida. 38
31025639 2019
32
Pulmonary Artery Banding for Congenitally Corrected Transposition of the Great Arteries With Hydrops Fetalis: A Case Report. 38
31018764 2019
33
Ultrasound evaluation of fetal critical aortic stenosis using the left atrium area/cardiac area ratio and the Doppler patterns in the pulmonary veins. 38
30288637 2019
34
Chromosomal abnormalities detected by karyotyping and chromosomal microarray analysis in twins with structural anomalies. 38
30977228 2019
35
Prenatal ultrasound findings of rasopathies in a cohort of 424 fetuses: update on genetic testing in the NGS era. 38
31040167 2019
36
Prenatal Diagnosis, Management, and Outcome of Fetal Subdural Haematoma: A Case Report and Systematic Review. 38
30861511 2019
37
Detection of a Large Novel α-Thalassemia Deletion in an Autochthonous Belgian Family. 38
31223040 2019
38
Non-immune hydrops fetalis neonate born to a mother with yellow nail syndrome. 38
30883972 2019
39
Atypical Prenatal Ultrasound Presentation and Neuropathological Findings in a Neonate With Alpha Thalassemia Major: A Case Report. 38
30550718 2019
40
[Clinical features and prognosis of neonates with nonimmune hydrops fetalis]. 38
30907350 2019
41
Fetal arrhythmias: diagnosis and treatment. 38
30879368 2019
42
Long-term follow-up and characteristic pathological findings in severe nemaline myopathy due to LMOD3 mutations. 38
30642739 2019
43
Congenital Large Cutaneous Hemangioma with Arteriovenous and Arterioarterial Malformations: A Novel Association. 38
30661487 2019
44
A cross-sectional quantitative analysis of the natural history of free sialic acid storage disease-an ultra-orphan multisystemic lysosomal storage disorder. 38
29875421 2019
45
Early fetal hydropic changes are associated with moderate dilatation of the brain ventricular system: A clue to a possible link between cervical lymphatic engorgement and ventricular dilatation? 38
31119910 2019
46
Maternal Parvovirus B19 Infection Causing First-Trimester Increased Nuchal Translucency and Fetal Hydrops. 38
31360565 2019
47
Hydrops Fetalis and Persistent Pulmonary Hypertension in a Neonate with Anti-E Alloimmunization. 38
30949372 2019
48
Immunostick Test for Detecting ζ-Globin Chains and Screening of the Southeast Asian α-Thalassemia 1 Deletion. 38
31388336 2019
49
Noonan syndrome: Severe phenotype and PTPN11 mutations. 38
29703613 2019
50
Biallelic loss of function variants in ATP1A2 cause hydrops fetalis, microcephaly, arthrogryposis and extensive cortical malformations. 38
30690204 2019

Variations for Fetal Edema

Expression for Fetal Edema

Search GEO for disease gene expression data for Fetal Edema.

Pathways for Fetal Edema

GO Terms for Fetal Edema

Sources for Fetal Edema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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