MCID: FTL004
MIFTS: 37

Fetal Erythroblastosis

Categories: Fetal diseases, Blood diseases

Aliases & Classifications for Fetal Erythroblastosis

MalaCards integrated aliases for Fetal Erythroblastosis:

Name: Fetal Erythroblastosis 12 15
Erythroblastosis, Fetal 44 73
Haemolytic Disease Due to Rhesus Isoimmunisation 12
Rhesus Isoimmunisation of the Newborn 12
Ef - Erythroblastosis Foetalis 12
Erythroblastosis Fetalis 12

Classifications:



Summaries for Fetal Erythroblastosis

MalaCards based summary : Fetal Erythroblastosis, also known as erythroblastosis, fetal, is related to kernicterus and rh-null, regulator type. An important gene associated with Fetal Erythroblastosis is RHCE (Rh Blood Group CcEe Antigens), and among its related pathways/superpathways are HIF-1 signaling pathway and Hematopoietic cell lineage. The drugs Antibodies and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include placenta, and related phenotype is liver/biliary system.

Related Diseases for Fetal Erythroblastosis

Diseases related to Fetal Erythroblastosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 kernicterus 31.4 ALB RHCE
2 rh-null, regulator type 10.9 RHCE RHD
3 retinohepatoendocrinologic syndrome 10.9 RHCE RHD
4 blood group incompatibility 10.8 RHCE RHD
5 scleredema adultorum 10.7 INS POMC
6 pituitary apoplexy 10.7 INS POMC
7 anemia, autoimmune hemolytic 10.6 GYPA RHCE RHD
8 autoimmune disease of blood 10.6 GYPA RHCE RHD
9 severe nonproliferative diabetic retinopathy 10.6 ALB INS
10 hyperpituitarism 10.6 INS POMC
11 burns 10.5 ALB INS
12 euthyroid sick syndrome 10.5 ALB POMC
13 background diabetic retinopathy 10.5 ALB INS
14 diabetic autonomic neuropathy 10.5 EPO INS
15 duodenal somatostatinoma 10.4 INS PPY
16 calciphylaxis 10.4 ALB EPO
17 autonomic nervous system disease 10.4 ALB INS
18 syndrome of inappropriate antidiuretic hormone 10.4 ALB POMC
19 splenic disease 10.4 ALB EPO
20 folic acid deficiency anemia 10.3 EPO TFRC
21 sheehan syndrome 10.3 EPO INS POMC
22 pneumocystosis 10.3 ALB GYPA
23 pure red-cell aplasia 10.3 ALB EPO
24 noma 10.3 ALB INS POMC
25 hereditary spherocytosis 10.2 GYPA HBE1 RHD
26 hypersplenism 10.2 ALB EPO
27 glucose metabolism disease 10.2 ALB INS POMC
28 hyperproinsulinemia 10.2 INS SHBG
29 hypoadrenalism 10.2 POMC SHBG
30 corticosteroid-binding globulin deficiency 10.2 ALB POMC
31 encephalopathy 10.2
32 uremia 10.2 ALB EPO INS
33 anemia of prematurity 10.2 EPO GYPA
34 kwashiorkor 10.2 ALB SHBG
35 marasmus 10.1 ALB SHBG
36 endocrine pancreas disease 10.1 INS POMC PPY
37 pancreas disease 10.1 INS POMC PPY
38 renal hypertension 10.1 ALB EPO
39 chronic kidney failure 10.1 ALB EPO INS
40 hemorrhagic fever 10.0 ALB TFRC
41 sex differentiation disease 10.0 INS POMC SHBG
42 gonadal disease 10.0 INS POMC SHBG
43 female reproductive system disease 10.0 INS POMC SHBG
44 hyperandrogenism 10.0 INS POMC SHBG
45 overnutrition 10.0 INS POMC SHBG
46 restless legs syndrome 10.0 EPO POMC TFRC
47 hemolytic anemia 10.0
48 shwartzman phenomenon 10.0
49 congenital hemolytic anemia 10.0
50 nutritional deficiency disease 9.9 ALB EPO TFRC

Graphical network of the top 20 diseases related to Fetal Erythroblastosis:



Diseases related to Fetal Erythroblastosis

Symptoms & Phenotypes for Fetal Erythroblastosis

MGI Mouse Phenotypes related to Fetal Erythroblastosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.1 EPO INS POMC TFRC ALB EBF1

Drugs & Therapeutics for Fetal Erythroblastosis

Drugs for Fetal Erythroblastosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 4,Early Phase 1
2 gamma-Globulins Phase 4,Early Phase 1
3 Immunoglobulins Phase 4,Early Phase 1
4 Immunoglobulins, Intravenous Phase 4,Early Phase 1
5 Pharmaceutical Solutions Phase 4
6 Rho(D) Immune Globulin Phase 4,Early Phase 1
7
Darbepoetin alfa Approved, Investigational Phase 2, Phase 3 11096-26-7, 209810-58-2
8 Hematinics Phase 2, Phase 3
9
Tin Phase 2 7440-31-5
10 Tin mesoporphyrin Phase 2
11
Menthol Approved Phase 1 2216-51-5 16666
12
Carbon monoxide Approved, Investigational 630-08-0 281
13 Antibodies, Anti-Idiotypic
14
Bilirubin Not Applicable 635-65-4 5280352
15 Antioxidants ,Not Applicable
16 Protective Agents ,Not Applicable
17 Anti-Arrhythmia Agents
18 Antimetabolites
19 Neurotransmitter Agents

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic Disease Completed NCT00288600 Phase 4 Intravenous Immunoglobulin;Normal saline solution
2 Doppler or Amniocentesis to Predict Fetal Anemia Completed NCT00295516 Phase 3
3 EPO-4-Rhesus Study Recruiting NCT03104426 Phase 2, Phase 3 Darbepoetin Alfa
4 Phase II Randomized Study of Tin Mesoporphyrin for Neonatal Hyperbilirubinemia Completed NCT00004381 Phase 2 tin mesoporphyrin
5 In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM) Recruiting NCT02986698 Phase 1
6 Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis Unknown status NCT00917007
7 Establish a Non-invasive Prenatal Genotyping and Extraction Technology to Diagnose and Treat the HDN. Approved for marketing NCT02969174
8 Does Maternal Instruction Prevent Kernicterus in Nigeria? Completed NCT02713464 Not Applicable
9 Determining Prevalence of Acute Bilirubin Encephalopathy in Developing Countries Completed NCT01754688
10 Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia Recruiting NCT03376438
11 Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm Infants Recruiting NCT02691156
12 Genotyping of Human Platelet Alloantigens : Non-invasive Prenatal Diagnosis Active, not recruiting NCT02899598 Not Applicable
13 Efficacy of Intravenous Immunoglobulin in Management of Rh and ABO Incompatibility Disease Not yet recruiting NCT03130517 Early Phase 1 intravenous immunoglobulin
14 Fetal Birth Defects: Toward a Precision-based Approach Not yet recruiting NCT03412760 Not Applicable
15 Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine Treatment Not yet recruiting NCT02956564 Not Applicable
16 Complications of Exchange Transfusion in Neonates Not yet recruiting NCT03195049 Not Applicable
17 Evaluation of Long-Term Gait Development in Infants With Neonatal Encephalopathy Using Infant Treadmill Not yet recruiting NCT03534466 Not Applicable
18 Evaluation of Long-term Neurodevelopment in Neonatal Encephalopathy by Infant Treadmill Not yet recruiting NCT03527498 Not Applicable
19 Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGR Terminated NCT00143039

Search NIH Clinical Center for Fetal Erythroblastosis

Cochrane evidence based reviews: erythroblastosis, fetal

Genetic Tests for Fetal Erythroblastosis

Anatomical Context for Fetal Erythroblastosis

MalaCards organs/tissues related to Fetal Erythroblastosis:

41
Placenta

Publications for Fetal Erythroblastosis

Articles related to Fetal Erythroblastosis:

# Title Authors Year
1
Fetal Erythroblastosis May Be an Indicator of Neonatal Transient Hyperinsulinism. ( 26044515 )
2015
2
Intraperitoneal and intracardiac transfusion of recurrent fetal erythroblastosis due to anti-M alloimmunization with unfavorable outcome. ( 22795103 )
2012
3
Successful treatment of fetal erythroblastosis due to anti-M alloimmunization with fetal intravascular transfusion. ( 17393557 )
2007
4
Treatment of fetal erythroblastosis by intravascular transfusions: outcome at 6 years. ( 9932548 )
1999
5
Intrauterine intravascular transfusions in fetal erythroblastosis: the influence of net transfusion volume on fetal survival. ( 8382426 )
1993
6
Intrauterine treatment of severe fetal erythroblastosis: intravascular transfusion with ultrasonic guidance. ( 2696779 )
1989
7
Metastasizing fetal neuroblastoma with involvement of the placenta simulating fetal erythroblastosis. Report of two cases. ( 4681867 )
1973
8
[Treatment of fetal erythroblastosis]. ( 14385270 )
1955
9
[Treatment of fetal erythroblastosis]. ( 14382988 )
1955
10
Exchange transfusion for fetal erythroblastosis. ( 14861736 )
1951

Variations for Fetal Erythroblastosis

Expression for Fetal Erythroblastosis

Search GEO for disease gene expression data for Fetal Erythroblastosis.

Pathways for Fetal Erythroblastosis

Pathways related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 EPO INS TFRC
2 11.12 EPO GYPA TFRC
3 10.44 ALB INS TFRC

GO Terms for Fetal Erythroblastosis

Cellular components related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ALB EPO INS POMC PPY SAA1
2 extracellular region GO:0005576 9.23 ALB EPO INS POMC PPY SAA1
3 hemoglobin complex GO:0005833 8.96 HBE1 HBZ

Biological processes related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.76 EPO INS POMC PPY
2 positive regulation of cytokine secretion GO:0050715 9.48 INS SAA1
3 organic cation transport GO:0015695 9.43 RHCE RHD
4 regulation of protein secretion GO:0050708 9.4 INS SAA1
5 oxygen transport GO:0015671 9.37 HBE1 HBZ
6 erythrocyte maturation GO:0043249 9.32 EPO HBZ
7 ammonium transmembrane transport GO:0072488 9.26 RHCE RHD
8 regulation of appetite GO:0032098 9.16 POMC PPY
9 ammonium transport GO:0015696 8.96 RHCE RHD
10 acute-phase response GO:0006953 8.8 EPO INS SAA1

Molecular functions related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.37 POMC PPY
2 G-protein coupled receptor binding GO:0001664 9.33 POMC PPY SAA1
3 oxygen carrier activity GO:0005344 9.32 HBE1 HBZ
4 ammonium transmembrane transporter activity GO:0008519 9.26 RHCE RHD
5 oxygen binding GO:0019825 9.13 ALB HBE1 HBZ
6 hormone activity GO:0005179 8.92 EPO INS POMC PPY

Sources for Fetal Erythroblastosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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