MCID: FTL004
MIFTS: 33

Fetal Erythroblastosis

Categories: Blood diseases, Fetal diseases

Aliases & Classifications for Fetal Erythroblastosis

MalaCards integrated aliases for Fetal Erythroblastosis:

Name: Fetal Erythroblastosis 12 6 15 17
Erythroblastosis, Fetal 44 70
Haemolytic Disease Due to Rhesus Isoimmunisation 12
Rhesus Isoimmunisation of the Newborn 12
Ef - Erythroblastosis Foetalis 12
Erythroblastosis Fetalis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1098
ICD9CM 34 773
MeSH 44 D004899
NCIt 50 C101304
SNOMED-CT 67 111468003
ICD10 32 P55
UMLS 70 C0014761

Summaries for Fetal Erythroblastosis

MalaCards based summary : Fetal Erythroblastosis, also known as erythroblastosis, fetal, is related to rh isoimmunization and bilirubin metabolic disorder. An important gene associated with Fetal Erythroblastosis is POLR1C (RNA Polymerase I And III Subunit C), and among its related pathways/superpathways are FOXA2 and FOXA3 transcription factor networks and Amino acid synthesis and interconversion (transamination). The drugs Pharmaceutical Solutions and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include placenta, bone marrow and bone.

Wikipedia : 73 Hemolytic disease of the newborn, also known as hemolytic disease of the fetus and newborn, HDN, HDFN,... more...

Related Diseases for Fetal Erythroblastosis

Diseases related to Fetal Erythroblastosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 rh isoimmunization 30.5 RHD RHCE
2 bilirubin metabolic disorder 30.4 RHD RHCE ALB
3 kernicterus 30.1 RHD RHCE ALB
4 asphyxia neonatorum 29.8 HADH ALB
5 blood group incompatibility 29.7 RHD RHCE KEL ALB
6 encephalopathy 10.2
7 glutamate-cysteine ligase deficiency 10.2 RHD RHCE
8 primary thrombocytopenia 10.2 RHD RHCE
9 retinohepatoendocrinologic syndrome 10.2
10 sickle cell anemia 10.2
11 cholestasis 10.2
12 neonatal jaundice 10.2
13 neonatal anemia 10.1 RHD RHCE KEL
14 splenic tuberculosis 10.1 SLC29A1 ALB
15 rh deficiency syndrome 10.1 RHD RHCE GYPA
16 orofaciodigital syndrome viii 10.1 RHCE PLAC4
17 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 1 10.1 GYPC GYPA
18 ankylosing spondylitis 3 10.1 FCGRT ALB
19 hemolytic anemia 10.1
20 hemoglobin d disease 10.1 GYPA ALB
21 patau syndrome 10.1 RHD RHCE PLAC4
22 anemia, autoimmune hemolytic 10.0 RHCE GYPA
23 immunodeficiency 43 10.0 FCGRT ALB
24 hyperinsulinemic hypoglycemia, familial, 7 10.0 HADH GLUD1
25 3-hydroxyacyl-coa dehydrogenase deficiency 10.0 HADH GLUD1
26 hereditary spherocytosis 10.0 RHD GYPC GYPA
27 branchiootic syndrome 1 10.0
28 obstructive jaundice 10.0
29 biliary atresia 10.0
30 shwartzman phenomenon 10.0
31 congenital hemolytic anemia 10.0
32 hyperinsulinemic hypoglycemia, familial, 6 10.0 HADH GLUD1
33 otopalatodigital syndrome spectrum disorder 10.0 RHD RHCE KEL GYPA
34 hemoglobinopathy 9.9 RHCE GYPA ALB
35 hereditary elliptocytosis 9.9 RHD RHCE GYPC GYPA
36 inclusion body myopathy with paget disease of bone and frontotemporal dementia 9.9 GYPC GYPA ALB
37 hydrops fetalis, nonimmune 9.9
38 lymphatic malformation 7 9.9
39 deficiency anemia 9.9
40 sarcoma 9.9
41 retroperitoneal sarcoma 9.9
42 hyperinsulinism 9.9
43 spindle cell sarcoma 9.9
44 neuroblastoma 9.9
45 hypoglycemia 9.9
46 granulomatous disease, chronic, x-linked 9.9 XK KEL
47 phagocyte bactericidal dysfunction 9.9 XK KEL
48 schopf-schulz-passarge syndrome 9.9 GLUD1 ALB
49 chickenpox 9.9 GYPC ALB
50 lingual-facial-buccal dyskinesia 9.8 XK KEL

Graphical network of the top 20 diseases related to Fetal Erythroblastosis:



Diseases related to Fetal Erythroblastosis

Symptoms & Phenotypes for Fetal Erythroblastosis

Drugs & Therapeutics for Fetal Erythroblastosis

Drugs for Fetal Erythroblastosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 4
2 Immunoglobulins Phase 4
3 Antibodies Phase 4
4 Immunologic Factors Phase 4
5 gamma-Globulins Phase 4
6 Immunoglobulins, Intravenous Phase 4
7 Rho(D) Immune Globulin Phase 4
8
Darbepoetin alfa Approved, Investigational Phase 2, Phase 3 209810-58-2, 11096-26-7
9 Hematinics Phase 2, Phase 3
10 Tin mesoporphyrin Phase 2
11 Antibodies, Anti-Idiotypic
12
Bilirubin 635-65-4 5280352

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 4 Study of Use of High-dose Intravenous Immune Globulin for Prevent Hyperbilirubinemia Due Rh Hemolytic Disease in Newborns Infants Completed NCT00288600 Phase 4 Intravenous Immunoglobulin;Normal saline solution
2 Randomized Controlled Trial on the Use of EPO to Reduce Top-up Transfusions in Neonates With Red Blood Cell Alloimmunization Treated With Intrauterine Transfusions Recruiting NCT03104426 Phase 2, Phase 3 Darbepoetin Alfa
3 Phase II Randomized Study of Tin Mesoporphyrin for Neonatal Hyperbilirubinemia Completed NCT00004381 Phase 2 tin mesoporphyrin
4 Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis in ABO-compatible and Incompatible Healthy Term Newborn Infants. Unknown status NCT00917007
5 A Multicenter, Prospective Observational Study to Characterize the Clinical Course of Pregnant Women and Children at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn Recruiting NCT03755128
6 Safe Threshold to Discontinue Phototherapy in Term and Late Preterm Infant With Hemolytic Disease of Newborn: A Randomized Controlled Trial Recruiting NCT04218318

Search NIH Clinical Center for Fetal Erythroblastosis

Cochrane evidence based reviews: erythroblastosis, fetal

Genetic Tests for Fetal Erythroblastosis

Anatomical Context for Fetal Erythroblastosis

MalaCards organs/tissues related to Fetal Erythroblastosis:

40
Placenta, Bone Marrow, Bone, Uterus

Publications for Fetal Erythroblastosis

Articles related to Fetal Erythroblastosis:

(show top 50) (show all 271)
# Title Authors PMID Year
1
CD15 immunostaining improves placental diagnosis of fetal hypoxia. 61
33545630 2021
2
Fetal Erythroblastosis May Be an Indicator of Neonatal Transient Hyperinsulinism. 61
26044515 2015
3
Immunotoxicity assessment of rice-derived recombinant human serum albumin using human peripheral blood mononuclear cells. 61
25099245 2014
4
Intraperitoneal and intracardiac transfusion of recurrent fetal erythroblastosis due to anti-M alloimmunization with unfavorable outcome. 61
22795103 2012
5
Intrauterine demise due to congenital mesoblastic nephroma in a fetus conceived by assisted reproductive technology. 61
21075369 2011
6
Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis. 61
18395034 2008
7
Rhesus immune globulin fails to prevent immunization after rhesus incompatible blood transfusion. 61
17368103 2007
8
Successful treatment of fetal erythroblastosis due to anti-M alloimmunization with fetal intravascular transfusion. 61
17393557 2007
9
Association of hypospadias and cardiac defect in a Parvovirus B19-infected stillborn: a causality relation? 61
16712940 2007
10
Fetal and embryonic hemoglobins in erythroblasts from fetal blood and fetal cells enriched from maternal blood in pregnancies complicated by maternal diabetes mellitus. 61
15209118 2004
11
RhD isoimmunization and current management modalities. 61
11724195 2001
12
[Blueberry muffin baby: the pathogenesis of cutaneous extramedullary hematopoiesis]. 61
11757459 2001
13
Fetal lactic dehydrogenase variation in normal pregnancy and in cases of severe intra-uterine growth restriction. 61
10210121 1999
14
Treatment of fetal erythroblastosis by intravascular transfusions: outcome at 6 years. 61
9932548 1999
15
Basal ganglia and thalamic calcification following intrauterine intravascular transfusion. 61
7823266 1994
16
[Antibody induction after intrauterine interventions]. 61
8374294 1993
17
Fetal plasma erythropoietin concentration in severe growth retardation. 61
8438939 1993
18
Intrauterine intravascular transfusions in fetal erythroblastosis: the influence of net transfusion volume on fetal survival. 61
8382426 1993
19
Fetal plasma erythropoietin concentration in red blood cell-isoimmunized pregnancies. 61
1442979 1992
20
[Decreased mortality in fetal erythroblastosis. There is a hope of a non-invasive method for the diagnosis of anemia]. 61
1552788 1992
21
[Specificity and incidence of erythrocyte antibodies in pregnant patients with intrauterine transfusions for fetal erythroblastosis]. 61
1284755 1992
22
[Blood picture findings in children with Parvovirus B19 infections (fifth disease/erythema infectiosum)]. 61
1660551 1991
23
[Care of shock patients--as exemplified by fetal hydrops due to severe fetal erythroblastosis]. 61
2400718 1990
24
[Characteristics of the renin-aldosterone system of the fetoplacental complex in fetal erythroblastosis]. 61
2118736 1990
25
[Prediction of the severity of fetal erythroblastosis using the erythrocyte phagocytosis test and evaluating anti-Rh antibody titers and their levels by autoanalysis]. 61
2122424 1990
26
[Rhesus immunization in a rhesus-positive pregnant woman: fetal erythroblastosis caused by the rhesus antibody anti-C]. 61
2506685 1989
27
[Diagnosis, perinatal therapy and prognosis of fetal erythroblastosis]. 61
2802698 1989
28
Intrauterine treatment of severe fetal erythroblastosis: intravascular transfusion with ultrasonic guidance. 61
2696779 1989
29
[Results of the blood serum examination for the presence of anti-ABO system antibodies in mothers of newborn infants with fetal erythroblastosis requiring exchange transfusion]. 61
3253666 1988
30
[Septicemia as a complication of fetal erythroblastosis in newborn infants]. 61
3252666 1988
31
[Prevention of fetal erythroblastosis with anti-D immunoglobulin]. 61
3150900 1988
32
[Effectiveness of the treatment of severe cases of fetal erythroblastosis by intrauterine blood transfusion]. 61
3150897 1988
33
[Infection risk factors in newborn infants with fetal erythroblastosis]. 61
3150899 1988
34
[Fetal erythroblastosis in Kell incompatibility]. 61
3471624 1987
35
Transplacental fetal hemorrhage after amniocentesis. 61
3934608 1985
36
Neuroblastoma in situ. 61
7201733 1982
37
[Diagnosis of fetal erythroblastosis and therapeutic procedures in blood group incompatibility]. 61
6814987 1982
38
[Blood chemical parameters in newborn infants with fetal erythroblastosis during exchange transfusion]. 61
7197006 1981
39
[Fetal erythroblastosis]. 61
6907720 1980
40
[Metabolism of erythrocytes in fetal erythroblastosis]. 61
6797027 1980
41
[Amniotic fluid diagnosis of fetal erythroblastosis following intrafetal transfusions (proceedings)]. 61
579765 1977
42
[The blood coagulation situation in fetal erythroblastosis before and after exchange transfusion]. 61
875996 1977
43
[Current treatment of fetal erythroblastosis]. 61
921731 1977
44
[Improved diagnosis fetal erythroblastosis due to Rh factors by combination of spectrophotometry (delta E 450) and a modified amniotic fluid ratio]. 61
822633 1976
45
Intra-uterine transfusion in the management of pregnant women with severe rhesus isoimmunization. I. Indications, technique, and complications. 61
1067711 1976
46
[Program for the prevention of fetal erythroblastosis]. 61
819880 1975
47
[Incidence of the sensitivity of Lalezari's test on the diagnosis and prevention of fetal erythroblastosis by anti-rhesus alloimmunization]. 61
819980 1975
48
[Cardiotocogram findings in antenatal monitoring of fetal hematoblastosis and during intrauterine intrafetal transfusion]. 61
811002 1975
49
[Proceedings: Differentiated surveillance in fetal erythroblastosis]. 61
4801535 1973
50
Metastasizing fetal neuroblastoma with involvement of the placenta simulating fetal erythroblastosis. Report of two cases. 61
4681867 1973

Variations for Fetal Erythroblastosis

ClinVar genetic disease variations for Fetal Erythroblastosis:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 POLR1C , SLC29A1 NM_001078177.2(SLC29A1):c.1159A>C (p.Thr387Pro) SNV Pathogenic 429191 rs1131690802 GRCh37: 6:44200643-44200643
GRCh38: 6:44232906-44232906

Expression for Fetal Erythroblastosis

Search GEO for disease gene expression data for Fetal Erythroblastosis.

Pathways for Fetal Erythroblastosis

Pathways related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.6 HADH ALB
2
Show member pathways
10.24 NAALAD2 GLUD1

GO Terms for Fetal Erythroblastosis

Biological processes related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular amino acid biosynthetic process GO:0008652 9.16 NAALAD2 GLUD1
2 ammonium transmembrane transport GO:0072488 8.96 RHD RHCE
3 ammonium transport GO:0015696 8.62 RHD RHCE

Molecular functions related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD+ binding GO:0070403 8.96 HADH GLUD1
2 ammonium transmembrane transporter activity GO:0008519 8.62 RHD RHCE

Sources for Fetal Erythroblastosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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