MCID: FTL004
MIFTS: 40

Fetal Erythroblastosis

Categories: Blood diseases, Fetal diseases

Aliases & Classifications for Fetal Erythroblastosis

MalaCards integrated aliases for Fetal Erythroblastosis:

Name: Fetal Erythroblastosis 12 15 17
Erythroblastosis, Fetal 45 74
Haemolytic Disease Due to Rhesus Isoimmunisation 12
Rhesus Isoimmunisation of the Newborn 12
Ef - Erythroblastosis Foetalis 12
Erythroblastosis Fetalis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1098
ICD9CM 36 773 773.2
MeSH 45 D004899
NCIt 51 C101304
SNOMED-CT 69 25121006 33130007
ICD10 34 P55 P55.9
UMLS 74 C0014761

Summaries for Fetal Erythroblastosis

MalaCards based summary : Fetal Erythroblastosis, also known as erythroblastosis, fetal, is related to retinohepatoendocrinologic syndrome and kernicterus. An important gene associated with Fetal Erythroblastosis is RHCE (Rh Blood Group CcEe Antigens), and among its related pathways/superpathways are HIF-1 signaling pathway and Hematopoietic cell lineage. The drugs Immunoglobulins and Rho(D) Immune Globulin have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and kidney, and related phenotype is liver/biliary system.

Wikipedia : 77 Hemolytic disease of the newborn, also known as hemolytic disease of the fetus and newborn, HDN, HDFN,... more...

Related Diseases for Fetal Erythroblastosis

Diseases related to Fetal Erythroblastosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 retinohepatoendocrinologic syndrome 32.7 RHCE RHD
2 kernicterus 31.2 ALB RHCE
3 blood group incompatibility 10.4 RHCE RHD
4 scleredema adultorum 10.3 INS POMC
5 encephalopathy 10.3
6 pituitary apoplexy 10.3 INS POMC
7 pancreatic endocrine carcinoma 10.3 INS POMC
8 bronchus cancer 10.3 POMC SAA1
9 mucinoses 10.3 INS POMC
10 anemia, autoimmune hemolytic 10.3 GYPA RHCE RHD
11 autoimmune disease of blood 10.3 GYPA RHCE RHD
12 severe nonproliferative diabetic retinopathy 10.3 ALB INS
13 hyperpituitarism 10.3 INS POMC
14 burns 10.3 ALB INS
15 sickle cell anemia 10.2
16 hemolytic anemia 10.2
17 bilirubin metabolic disorder 10.2
18 hypoglycemia 10.2
19 drug allergy 10.2 ALB INS
20 diabetic autonomic neuropathy 10.2 EPO INS
21 background diabetic retinopathy 10.2 ALB INS
22 duodenal somatostatinoma 10.2 INS PPY
23 calciphylaxis 10.2 ALB EPO
24 euthyroid sick syndrome 10.2 ALB POMC
25 folic acid deficiency anemia 10.2 EPO TFRC
26 thyroid crisis 10.2 ALB POMC
27 plethora of newborn 10.2 EPO INS
28 microvascular complications of diabetes 3 10.2 ALB INS
29 syndrome of inappropriate antidiuretic hormone 10.2 ALB POMC
30 splenic disease 10.1 ALB EPO
31 postmenopausal atrophic vaginitis 10.1 POMC SHBG
32 sheehan syndrome 10.1 EPO INS POMC
33 noma 10.1 ALB INS POMC
34 hyperproinsulinemia 10.1 INS SHBG
35 fascioliasis 10.1 ALB INS
36 hypoadrenalism 10.1 POMC SHBG
37 glucose metabolism disease 10.1 ALB INS POMC
38 obstructive jaundice 10.1
39 shwartzman phenomenon 10.1
40 congenital hemolytic anemia 10.1
41 autonomic nervous system disease 10.1 ALB INS
42 uremia 10.1 ALB EPO INS
43 marasmus 10.1 ALB SHBG
44 kwashiorkor 10.1 ALB SHBG
45 pigmentation disease 10.0 INS SHBG
46 pure red-cell aplasia 10.0 ALB EPO
47 hyperandrogenism 10.0 INS POMC SHBG
48 overnutrition 10.0 INS POMC SHBG
49 gonadal disease 10.0 INS POMC SHBG
50 hyperinsulinism 10.0

Graphical network of the top 20 diseases related to Fetal Erythroblastosis:



Diseases related to Fetal Erythroblastosis

Symptoms & Phenotypes for Fetal Erythroblastosis

MGI Mouse Phenotypes related to Fetal Erythroblastosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.1 ALB EBF1 EPO INS POMC TFRC

Drugs & Therapeutics for Fetal Erythroblastosis

Drugs for Fetal Erythroblastosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 4,Phase 2,Early Phase 1
2 Rho(D) Immune Globulin Phase 4,Early Phase 1
3 gamma-Globulins Phase 4,Early Phase 1
4 Immunoglobulins, Intravenous Phase 4,Early Phase 1
5 Antibodies Phase 4,Phase 2,Early Phase 1
6 Immunologic Factors Phase 4,Early Phase 1
7 Pharmaceutical Solutions Phase 4
8
Darbepoetin alfa Approved, Investigational Phase 2, Phase 3 209810-58-2, 11096-26-7
9 Hematinics Phase 2, Phase 3
10
Tin Phase 2 7440-31-5
11 Tin mesoporphyrin Phase 2
12
Carbon monoxide Approved, Investigational 630-08-0 281
13 Antibodies, Anti-Idiotypic
14
Bilirubin Not Applicable 635-65-4, 69853-43-6 21252250 5280352
15 Protective Agents ,Not Applicable
16 Antioxidants ,Not Applicable
17 Anti-Arrhythmia Agents
18 Antimetabolites
19 Neurotransmitter Agents

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic Disease Completed NCT00288600 Phase 4 Intravenous Immunoglobulin;Normal saline solution
2 Doppler or Amniocentesis to Predict Fetal Anemia Completed NCT00295516 Phase 3
3 EPO-4-Rhesus Study Recruiting NCT03104426 Phase 2, Phase 3 Darbepoetin Alfa
4 Phase II Randomized Study of Tin Mesoporphyrin for Neonatal Hyperbilirubinemia Completed NCT00004381 Phase 2 tin mesoporphyrin
5 A Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of M281 Administered to Pregnant Women at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn (HDFN) Recruiting NCT03842189 Phase 2 M281
6 In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM) Recruiting NCT02986698 Phase 1
7 Genotyping of Human Platelet Alloantigens : Non-invasive Prenatal Diagnosis Unknown status NCT02899598 Not Applicable
8 Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis Unknown status NCT00917007
9 Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine Treatment Unknown status NCT02956564 Not Applicable
10 Establish a Non-invasive Prenatal Genotyping and Extraction Technology to Diagnose and Treat the HDN. Approved for marketing NCT02969174
11 Does Maternal Instruction Prevent Kernicterus in Nigeria? Completed NCT02713464 Not Applicable
12 Determining Prevalence of Acute Bilirubin Encephalopathy in Developing Countries Completed NCT01754688
13 A Study to Characterize the Clinical Course of Pregnant Women and Children at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn Recruiting NCT03755128
14 Whole Exome Sequencing and Whole Genome Sequencing for Non-immune Fetal/Neonatal Hydrops Recruiting NCT03911531
15 Hydrops: Diagnosing & Redefining Outcomes With Precision Study Recruiting NCT03412760 Not Applicable
16 Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise Recruiting NCT03775954
17 Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia Recruiting NCT03376438
18 Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm Infants Recruiting NCT02691156
19 Efficacy of Intravenous Immunoglobulin in Management of Rh and ABO Incompatibility Disease Not yet recruiting NCT03130517 Early Phase 1 intravenous immunoglobulin
20 Complications of Exchange Transfusion in Neonates Not yet recruiting NCT03195049 Not Applicable
21 Evaluation of Long-Term Gait Development in Infants With Neonatal Encephalopathy Using Infant Treadmill Not yet recruiting NCT03534466 Not Applicable
22 Evaluation of Long-term Neurodevelopment in Neonatal Encephalopathy by Infant Treadmill Not yet recruiting NCT03527498 Not Applicable
23 Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGR Terminated NCT00143039

Search NIH Clinical Center for Fetal Erythroblastosis

Cochrane evidence based reviews: erythroblastosis, fetal

Genetic Tests for Fetal Erythroblastosis

Anatomical Context for Fetal Erythroblastosis

MalaCards organs/tissues related to Fetal Erythroblastosis:

42
Placenta, Heart, Kidney, Pituitary, Pancreas, Thyroid

Publications for Fetal Erythroblastosis

Articles related to Fetal Erythroblastosis:

# Title Authors Year
1
Fetal Erythroblastosis May Be an Indicator of Neonatal Transient Hyperinsulinism. ( 26044515 )
2015
2
Intraperitoneal and intracardiac transfusion of recurrent fetal erythroblastosis due to anti-M alloimmunization with unfavorable outcome. ( 22795103 )
2012
3
Successful treatment of fetal erythroblastosis due to anti-M alloimmunization with fetal intravascular transfusion. ( 17393557 )
2007
4
Treatment of fetal erythroblastosis by intravascular transfusions: outcome at 6 years. ( 9932548 )
1999
5
Intrauterine intravascular transfusions in fetal erythroblastosis: the influence of net transfusion volume on fetal survival. ( 8382426 )
1993
6
Intrauterine treatment of severe fetal erythroblastosis: intravascular transfusion with ultrasonic guidance. ( 2696779 )
1989
7
Metastasizing fetal neuroblastoma with involvement of the placenta simulating fetal erythroblastosis. Report of two cases. ( 4681867 )
1973
8
[Treatment of fetal erythroblastosis]. ( 14382988 )
1955
9
[Treatment of fetal erythroblastosis]. ( 14385270 )
1955
10
Exchange transfusion for fetal erythroblastosis. ( 14861736 )
1951

Variations for Fetal Erythroblastosis

Expression for Fetal Erythroblastosis

Search GEO for disease gene expression data for Fetal Erythroblastosis.

Pathways for Fetal Erythroblastosis

Pathways related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 EPO INS TFRC
2 11.32 EPO GYPA TFRC
3 10.81 ABO EPO GYPA
4 10.44 ALB INS TFRC

GO Terms for Fetal Erythroblastosis

Cellular components related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ALB EPO INS POMC PPY SAA1
2 blood microparticle GO:0072562 9.5 ALB HBE1 TFRC
3 extracellular region GO:0005576 9.28 ABO ALB EPO INS POMC PPY
4 hemoglobin complex GO:0005833 9.16 HBE1 HBZ
5 haptoglobin-hemoglobin complex GO:0031838 8.96 HBE1 HBZ

Biological processes related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.78 EPO INS POMC PPY
2 hydrogen peroxide catabolic process GO:0042744 9.46 HBE1 HBZ
3 positive regulation of cytokine secretion GO:0050715 9.43 INS SAA1
4 oxygen transport GO:0015671 9.4 HBE1 HBZ
5 erythrocyte maturation GO:0043249 9.37 EPO HBZ
6 cellular oxidant detoxification GO:0098869 9.33 ALB HBE1 HBZ
7 regulation of protein secretion GO:0050708 9.32 INS SAA1
8 ammonium transmembrane transport GO:0072488 9.26 RHCE RHD
9 ammonium transport GO:0015696 8.96 RHCE RHD
10 acute-phase response GO:0006953 8.8 EPO INS SAA1

Molecular functions related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 9.43 HBE1 HBZ
2 oxygen carrier activity GO:0005344 9.4 HBE1 HBZ
3 organic acid binding GO:0043177 9.37 HBE1 HBZ
4 G protein-coupled receptor binding GO:0001664 9.33 POMC PPY SAA1
5 haptoglobin binding GO:0031720 9.32 HBE1 HBZ
6 ammonium transmembrane transporter activity GO:0008519 9.26 RHCE RHD
7 oxygen binding GO:0019825 9.13 ALB HBE1 HBZ
8 hormone activity GO:0005179 8.92 EPO INS POMC PPY

Sources for Fetal Erythroblastosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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