MCID: FTL004
MIFTS: 38

Fetal Erythroblastosis

Categories: Blood diseases, Fetal diseases

Aliases & Classifications for Fetal Erythroblastosis

MalaCards integrated aliases for Fetal Erythroblastosis:

Name: Fetal Erythroblastosis 12 15
Erythroblastosis, Fetal 44 73
Haemolytic Disease Due to Rhesus Isoimmunisation 12
Rhesus Isoimmunisation of the Newborn 12
Ef - Erythroblastosis Foetalis 12
Erythroblastosis Fetalis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1098
ICD10 33 P55 P55.9
ICD9CM 35 773 773.2
MeSH 44 D004899
NCIt 50 C101304
SNOMED-CT 68 25121006 33130007
UMLS 73 C0014761

Summaries for Fetal Erythroblastosis

MalaCards based summary : Fetal Erythroblastosis, also known as erythroblastosis, fetal, is related to retinohepatoendocrinologic syndrome and kernicterus. An important gene associated with Fetal Erythroblastosis is RHCE (Rh Blood Group CcEe Antigens), and among its related pathways/superpathways are HIF-1 signaling pathway and Hematopoietic cell lineage. The drugs Darbepoetin alfa and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and kidney, and related phenotype is liver/biliary system.

Wikipedia : 76 Hemolytic disease of the newborn, also known as hemolytic disease of the fetus and newborn, HDN, HDFN,... more...

Related Diseases for Fetal Erythroblastosis

Diseases related to Fetal Erythroblastosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 retinohepatoendocrinologic syndrome 32.4 RHCE RHD
2 kernicterus 31.1 ALB RHCE
3 encephalopathy 10.3
4 blood group incompatibility 10.3 RHCE RHD
5 scleredema adultorum 10.2 INS POMC
6 pituitary apoplexy 10.2 INS POMC
7 pancreatic endocrine carcinoma 10.2 INS POMC
8 mucinoses 10.2 INS POMC
9 bronchus cancer 10.2 POMC SAA1
10 hyperpituitarism 10.2 INS POMC
11 severe nonproliferative diabetic retinopathy 10.2 ALB INS
12 coccidiosis 10.2 RHCE RHD
13 anemia, autoimmune hemolytic 10.2 GYPA RHCE RHD
14 autoimmune disease of blood 10.2 GYPA RHCE RHD
15 diabetic autonomic neuropathy 10.2 EPO INS
16 drug allergy 10.2 ALB INS
17 background diabetic retinopathy 10.2 ALB INS
18 plethora of newborn 10.2 EPO INS
19 euthyroid sick syndrome 10.2 ALB POMC
20 pigmentation disease 10.2 INS POMC
21 calciphylaxis 10.2 ALB EPO
22 thyroid crisis 10.1 ALB POMC
23 microvascular complications of diabetes 3 10.1 ALB INS
24 duodenal somatostatinoma 10.1 INS PPY
25 syndrome of inappropriate antidiuretic hormone 10.1 ALB POMC
26 fascioliasis 10.1 ALB INS
27 folic acid deficiency anemia 10.1 EPO TFRC
28 autonomic nervous system disease 10.1 ALB INS
29 splenic disease 10.1 ALB EPO
30 neurodermatitis 10.1 INS POMC
31 pneumocystosis 10.1 ALB GYPA
32 pure red-cell aplasia 10.1 ALB EPO
33 postmenopausal atrophic vaginitis 10.1 POMC SHBG
34 hypersplenism 10.1 ALB EPO
35 sheehan syndrome 10.1 EPO INS POMC
36 hyperproinsulinemia 10.1 INS SHBG
37 hypoadrenalism 10.1 POMC SHBG
38 noma 10.1 ALB INS POMC
39 hemolytic anemia 10.1
40 shwartzman phenomenon 10.1
41 congenital hemolytic anemia 10.1
42 hypoglycemia 10.1
43 corticosteroid-binding globulin deficiency 10.1 ALB POMC
44 glucose metabolism disease 10.1 ALB INS POMC
45 anemia of prematurity 10.1 EPO GYPA
46 hemorrhagic fever 10.1 ALB TFRC
47 uremia 10.1 ALB EPO INS
48 marasmus 10.1 ALB SHBG
49 kwashiorkor 10.1 ALB SHBG
50 renal hypertension 10.0 ALB EPO

Graphical network of the top 20 diseases related to Fetal Erythroblastosis:



Diseases related to Fetal Erythroblastosis

Symptoms & Phenotypes for Fetal Erythroblastosis

MGI Mouse Phenotypes related to Fetal Erythroblastosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.1 ALB EBF1 EPO INS POMC TFRC

Drugs & Therapeutics for Fetal Erythroblastosis

Drugs for Fetal Erythroblastosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darbepoetin alfa Approved, Investigational Phase 2, Phase 3 11096-26-7, 209810-58-2
2 Hematinics Phase 2, Phase 3
3 Tin mesoporphyrin Phase 2
4
Tin Phase 2 7440-31-5
5 Antibodies, Anti-Idiotypic
6 Antibodies Early Phase 1
7 Immunologic Factors Early Phase 1
8 Immunoglobulins Early Phase 1
9 Immunoglobulins, Intravenous Early Phase 1
10 gamma-Globulins Early Phase 1
11 Rho(D) Immune Globulin Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Doppler or Amniocentesis to Predict Fetal Anemia Completed NCT00295516 Phase 3
2 EPO-4-Rhesus Study Recruiting NCT03104426 Phase 2, Phase 3 Darbepoetin Alfa
3 Phase II Randomized Study of Tin Mesoporphyrin for Neonatal Hyperbilirubinemia Completed NCT00004381 Phase 2 tin mesoporphyrin
4 Genotyping of Human Platelet Alloantigens : Non-invasive Prenatal Diagnosis Unknown status NCT02899598 Not Applicable
5 Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis Unknown status NCT00917007
6 Establish a Non-invasive Prenatal Genotyping and Extraction Technology to Diagnose and Treat the HDN. Approved for marketing NCT02969174
7 Efficacy of Intravenous Immunoglobulin in Management of Rh and ABO Incompatibility Disease Not yet recruiting NCT03130517 Early Phase 1 intravenous immunoglobulin

Search NIH Clinical Center for Fetal Erythroblastosis

Cochrane evidence based reviews: erythroblastosis, fetal

Genetic Tests for Fetal Erythroblastosis

Anatomical Context for Fetal Erythroblastosis

MalaCards organs/tissues related to Fetal Erythroblastosis:

41
Placenta, Heart, Kidney, Pituitary, Pancreas, Thyroid

Publications for Fetal Erythroblastosis

Articles related to Fetal Erythroblastosis:

# Title Authors Year
1
Fetal Erythroblastosis May Be an Indicator of Neonatal Transient Hyperinsulinism. ( 26044515 )
2015
2
Intraperitoneal and intracardiac transfusion of recurrent fetal erythroblastosis due to anti-M alloimmunization with unfavorable outcome. ( 22795103 )
2012
3
Successful treatment of fetal erythroblastosis due to anti-M alloimmunization with fetal intravascular transfusion. ( 17393557 )
2007
4
Treatment of fetal erythroblastosis by intravascular transfusions: outcome at 6 years. ( 9932548 )
1999
5
Intrauterine intravascular transfusions in fetal erythroblastosis: the influence of net transfusion volume on fetal survival. ( 8382426 )
1993
6
Intrauterine treatment of severe fetal erythroblastosis: intravascular transfusion with ultrasonic guidance. ( 2696779 )
1989
7
Metastasizing fetal neuroblastoma with involvement of the placenta simulating fetal erythroblastosis. Report of two cases. ( 4681867 )
1973
8
[Treatment of fetal erythroblastosis]. ( 14385270 )
1955
9
[Treatment of fetal erythroblastosis]. ( 14382988 )
1955
10
Exchange transfusion for fetal erythroblastosis. ( 14861736 )
1951

Variations for Fetal Erythroblastosis

Expression for Fetal Erythroblastosis

Search GEO for disease gene expression data for Fetal Erythroblastosis.

Pathways for Fetal Erythroblastosis

Pathways related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 EPO INS TFRC
2 11.12 EPO GYPA TFRC
3 10.44 ALB INS TFRC

GO Terms for Fetal Erythroblastosis

Cellular components related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ALB EPO INS POMC PPY SAA1
2 blood microparticle GO:0072562 9.5 ALB HBE1 TFRC
3 extracellular region GO:0005576 9.23 ALB EPO INS POMC PPY SAA1
4 hemoglobin complex GO:0005833 9.16 HBE1 HBZ
5 haptoglobin-hemoglobin complex GO:0031838 8.96 HBE1 HBZ

Biological processes related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.73 EPO INS POMC PPY
2 hydrogen peroxide catabolic process GO:0042744 9.48 HBE1 HBZ
3 positive regulation of cytokine secretion GO:0050715 9.46 INS SAA1
4 oxygen transport GO:0015671 9.4 HBE1 HBZ
5 erythrocyte maturation GO:0043249 9.37 EPO HBZ
6 cellular oxidant detoxification GO:0098869 9.33 ALB HBE1 HBZ
7 regulation of protein secretion GO:0050708 9.32 INS SAA1
8 ammonium transmembrane transport GO:0072488 9.26 RHCE RHD
9 ammonium transport GO:0015696 8.96 RHCE RHD
10 acute-phase response GO:0006953 8.8 EPO INS SAA1

Molecular functions related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 9.43 HBE1 HBZ
2 oxygen carrier activity GO:0005344 9.4 HBE1 HBZ
3 organic acid binding GO:0043177 9.37 HBE1 HBZ
4 G protein-coupled receptor binding GO:0001664 9.33 POMC PPY SAA1
5 haptoglobin binding GO:0031720 9.32 HBE1 HBZ
6 ammonium transmembrane transporter activity GO:0008519 9.26 RHCE RHD
7 oxygen binding GO:0019825 9.13 ALB HBE1 HBZ
8 hormone activity GO:0005179 8.92 EPO INS POMC PPY

Sources for Fetal Erythroblastosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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