MCID: FTL004
MIFTS: 32

Fetal Erythroblastosis

Categories: Blood diseases, Fetal diseases

Aliases & Classifications for Fetal Erythroblastosis

MalaCards integrated aliases for Fetal Erythroblastosis:

Name: Fetal Erythroblastosis 12 15 17
Erythroblastosis, Fetal 43 71
Haemolytic Disease Due to Rhesus Isoimmunisation 12
Rhesus Isoimmunisation of the Newborn 12
Ef - Erythroblastosis Foetalis 12
Erythroblastosis Fetalis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1098
ICD9CM 34 773 773.2
MeSH 43 D004899
NCIt 49 C101304
SNOMED-CT 67 25121006 33130007
ICD10 32 P55 P55.9
UMLS 71 C0014761

Summaries for Fetal Erythroblastosis

MalaCards based summary : Fetal Erythroblastosis, also known as erythroblastosis, fetal, is related to rh isoimmunization and kernicterus. An important gene associated with Fetal Erythroblastosis is RHCE (Rh Blood Group CcEe Antigens), and among its related pathways/superpathways are Malaria and Hematopoietic Stem Cell Differentiation. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and testes, and related phenotype is homeostasis/metabolism.

Wikipedia : 74 Hemolytic disease of the newborn, also known as hemolytic disease of the fetus and newborn, HDN, HDFN,... more...

Related Diseases for Fetal Erythroblastosis

Diseases related to Fetal Erythroblastosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 rh isoimmunization 30.2 RHD RHCE ABO
2 kernicterus 30.1 RHD RHCE ABO
3 blood group incompatibility 29.6 RHD RHCE KEL ABO
4 bilirubin metabolic disorder 10.4
5 encephalopathy 10.3
6 sickle cell anemia 10.2
7 cholestasis 10.2
8 neonatal jaundice 10.2
9 hemolytic anemia 10.1
10 primary thrombocytopenia 10.1 RHD RHCE
11 branchiootic syndrome 1 10.1
12 hydrops, lactic acidosis, and sideroblastic anemia 10.1
13 obstructive jaundice 10.1
14 biliary atresia 10.1
15 shwartzman phenomenon 10.1
16 congestive heart failure 10.1
17 congenital hemolytic anemia 10.1
18 patau syndrome 10.0 RHD RHCE
19 neonatal anemia 10.0 RHD RHCE KEL
20 autoimmune disease of blood 10.0 RHD RHCE
21 hydrops fetalis, nonimmune 10.0
22 deficiency anemia 10.0
23 asphyxia neonatorum 10.0
24 sarcoma 10.0
25 retroperitoneal sarcoma 10.0
26 hyperinsulinism 10.0
27 spindle cell sarcoma 10.0
28 neuroblastoma 10.0
29 hypoglycemia 10.0
30 retinohepatoendocrinologic syndrome 9.9 RHD RHCE GYPA
31 thrombocytopenia due to platelet alloimmunization 9.9 RHCE FCGRT
32 3-hydroxyacyl-coa dehydrogenase deficiency 9.9 HADH GLUD1
33 hyperinsulinemic hypoglycemia, familial, 6 9.9 HADH GLUD1
34 hyperinsulinemic hypoglycemia 9.9 HADH GLUD1
35 hyperinsulinemic hypoglycemia, familial, 7 9.8 HADH GLUD1
36 anemia, autoimmune hemolytic 9.7 RHCE GYPA
37 hereditary elliptocytosis 9.6 RHD GYPC GYPA ABO
38 malaria 9.2 RHD RHCE GYPC GYPA ABO
39 hereditary spherocytosis 9.2 ZFPM1 RHD GYPC GYPA

Graphical network of the top 20 diseases related to Fetal Erythroblastosis:



Diseases related to Fetal Erythroblastosis

Symptoms & Phenotypes for Fetal Erythroblastosis

MGI Mouse Phenotypes related to Fetal Erythroblastosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 CCDC120 FCGRT GLUD1 GYPC HADH KEL

Drugs & Therapeutics for Fetal Erythroblastosis

Drugs for Fetal Erythroblastosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 4
2 Antibodies Phase 4
3 Immunologic Factors Phase 4
4 Pharmaceutical Solutions Phase 4
5 Rho(D) Immune Globulin Phase 4
6 gamma-Globulins Phase 4
7 Immunoglobulins, Intravenous Phase 4
8
Darbepoetin alfa Approved, Investigational Phase 2, Phase 3 11096-26-7, 209810-58-2
9 Hematinics Phase 2, Phase 3
10 Tin mesoporphyrin Phase 2
11
Tin Phase 2 7440-31-5
12 Antibodies, Anti-Idiotypic

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 4 Study of Use of High-dose Intravenous Immune Globulin for Prevent Hyperbilirubinemia Due Rh Hemolytic Disease in Newborns Infants Completed NCT00288600 Phase 4 Intravenous Immunoglobulin;Normal saline solution
2 Minimally Invasive Management of Rh Alloimmunization: Can Amniotic Fluid DeltaOD450 Measurements Be Replaced by Doppler Studies? Completed NCT00295516 Phase 3
3 Randomized Controlled Trial on the Use of EPO to Reduce Top-up Transfusions in Neonates With Red Blood Cell Alloimmunization Treated With Intrauterine Transfusions Recruiting NCT03104426 Phase 2, Phase 3 Darbepoetin Alfa
4 Phase II Randomized Study of Tin Mesoporphyrin for Neonatal Hyperbilirubinemia Completed NCT00004381 Phase 2 tin mesoporphyrin
5 Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis in ABO-compatible and Incompatible Healthy Term Newborn Infants. Unknown status NCT00917007
6 A Multicenter, Prospective Observational Study to Characterize the Clinical Course of Pregnant Women and Children at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn Recruiting NCT03755128

Search NIH Clinical Center for Fetal Erythroblastosis

Cochrane evidence based reviews: erythroblastosis, fetal

Genetic Tests for Fetal Erythroblastosis

Anatomical Context for Fetal Erythroblastosis

MalaCards organs/tissues related to Fetal Erythroblastosis:

40
Placenta, Heart, Testes, Bone Marrow, Bone, Uterus

Publications for Fetal Erythroblastosis

Articles related to Fetal Erythroblastosis:

(show top 50) (show all 237)
# Title Authors PMID Year
1
Fetal Erythroblastosis May Be an Indicator of Neonatal Transient Hyperinsulinism. 61
26044515 2015
2
Immunotoxicity assessment of rice-derived recombinant human serum albumin using human peripheral blood mononuclear cells. 61
25099245 2014
3
Intraperitoneal and intracardiac transfusion of recurrent fetal erythroblastosis due to anti-M alloimmunization with unfavorable outcome. 61
22795103 2012
4
Intrauterine demise due to congenital mesoblastic nephroma in a fetus conceived by assisted reproductive technology. 61
21075369 2011
5
Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis. 61
18395034 2008
6
Successful treatment of fetal erythroblastosis due to anti-M alloimmunization with fetal intravascular transfusion. 61
17393557 2007
7
Rhesus immune globulin fails to prevent immunization after rhesus incompatible blood transfusion. 61
17368103 2007
8
Association of hypospadias and cardiac defect in a Parvovirus B19-infected stillborn: a causality relation? 61
16712940 2007
9
Fetal and embryonic hemoglobins in erythroblasts from fetal blood and fetal cells enriched from maternal blood in pregnancies complicated by maternal diabetes mellitus. 61
15209118 2004
10
[Blueberry muffin baby: the pathogenesis of cutaneous extramedullary hematopoiesis]. 61
11757459 2001
11
RhD isoimmunization and current management modalities. 61
11724195 2001
12
Fetal lactic dehydrogenase variation in normal pregnancy and in cases of severe intra-uterine growth restriction. 61
10210121 1999
13
Treatment of fetal erythroblastosis by intravascular transfusions: outcome at 6 years. 61
9932548 1999
14
Basal ganglia and thalamic calcification following intrauterine intravascular transfusion. 61
7823266 1994
15
[Antibody induction after intrauterine interventions]. 61
8374294 1993
16
Fetal plasma erythropoietin concentration in severe growth retardation. 61
8438939 1993
17
Intrauterine intravascular transfusions in fetal erythroblastosis: the influence of net transfusion volume on fetal survival. 61
8382426 1993
18
Fetal plasma erythropoietin concentration in red blood cell-isoimmunized pregnancies. 61
1442979 1992
19
[Decreased mortality in fetal erythroblastosis. There is a hope of a non-invasive method for the diagnosis of anemia]. 61
1552788 1992
20
[Specificity and incidence of erythrocyte antibodies in pregnant patients with intrauterine transfusions for fetal erythroblastosis]. 61
1284755 1992
21
[Blood picture findings in children with Parvovirus B19 infections (fifth disease/erythema infectiosum)]. 61
1660551 1991
22
[Care of shock patients--as exemplified by fetal hydrops due to severe fetal erythroblastosis]. 61
2400718 1990
23
[Characteristics of the renin-aldosterone system of the fetoplacental complex in fetal erythroblastosis]. 61
2118736 1990
24
[Prediction of the severity of fetal erythroblastosis using the erythrocyte phagocytosis test and evaluating anti-Rh antibody titers and their levels by autoanalysis]. 61
2122424 1990
25
[Rhesus immunization in a rhesus-positive pregnant woman: fetal erythroblastosis caused by the rhesus antibody anti-C]. 61
2506685 1989
26
Intrauterine treatment of severe fetal erythroblastosis: intravascular transfusion with ultrasonic guidance. 61
2696779 1989
27
[Diagnosis, perinatal therapy and prognosis of fetal erythroblastosis]. 61
2802698 1989
28
[Results of the blood serum examination for the presence of anti-ABO system antibodies in mothers of newborn infants with fetal erythroblastosis requiring exchange transfusion]. 61
3253666 1988
29
[Effectiveness of the treatment of severe cases of fetal erythroblastosis by intrauterine blood transfusion]. 61
3150897 1988
30
[Septicemia as a complication of fetal erythroblastosis in newborn infants]. 61
3252666 1988
31
[Infection risk factors in newborn infants with fetal erythroblastosis]. 61
3150899 1988
32
[Prevention of fetal erythroblastosis with anti-D immunoglobulin]. 61
3150900 1988
33
[Fetal erythroblastosis in Kell incompatibility]. 61
3471624 1987
34
Transplacental fetal hemorrhage after amniocentesis. 61
3934608 1985
35
Neuroblastoma in situ. 61
7201733 1982
36
[Diagnosis of fetal erythroblastosis and therapeutic procedures in blood group incompatibility]. 61
6814987 1982
37
[Blood chemical parameters in newborn infants with fetal erythroblastosis during exchange transfusion]. 61
7197006 1981
38
[Fetal erythroblastosis]. 61
6907720 1980
39
[Metabolism of erythrocytes in fetal erythroblastosis]. 61
6797027 1980
40
[Amniotic fluid diagnosis of fetal erythroblastosis following intrafetal transfusions (proceedings)]. 61
579765 1977
41
[The blood coagulation situation in fetal erythroblastosis before and after exchange transfusion]. 61
875996 1977
42
[Current treatment of fetal erythroblastosis]. 61
921731 1977
43
[Improved diagnosis fetal erythroblastosis due to Rh factors by combination of spectrophotometry (delta E 450) and a modified amniotic fluid ratio]. 61
822633 1976
44
Intra-uterine transfusion in the management of pregnant women with severe rhesus isoimmunization. I. Indications, technique, and complications. 61
1067711 1976
45
[Incidence of the sensitivity of Lalezari's test on the diagnosis and prevention of fetal erythroblastosis by anti-rhesus alloimmunization]. 61
819980 1975
46
[Program for the prevention of fetal erythroblastosis]. 61
819880 1975
47
[Cardiotocogram findings in antenatal monitoring of fetal hematoblastosis and during intrauterine intrafetal transfusion]. 61
811002 1975
48
[Proceedings: Differentiated surveillance in fetal erythroblastosis]. 61
4801535 1973
49
[The role of phototherapy in the treatment of fetal erythroblastosis]. 61
4199948 1973
50
Metastasizing fetal neuroblastoma with involvement of the placenta simulating fetal erythroblastosis. Report of two cases. 61
4681867 1973

Variations for Fetal Erythroblastosis

Expression for Fetal Erythroblastosis

Search GEO for disease gene expression data for Fetal Erythroblastosis.

Pathways for Fetal Erythroblastosis

Pathways related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.65 GYPC GYPA
2 10.3 GYPA ABO

GO Terms for Fetal Erythroblastosis

Biological processes related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ammonium transmembrane transport GO:0072488 8.96 RHD RHCE
2 ammonium transport GO:0015696 8.62 RHD RHCE

Molecular functions related to Fetal Erythroblastosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD+ binding GO:0070403 8.96 HADH GLUD1
2 ammonium transmembrane transporter activity GO:0008519 8.62 RHD RHCE

Sources for Fetal Erythroblastosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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