MCID: FTL007
MIFTS: 31

Fetal Hydantoin Syndrome

Categories: Rare diseases, Fetal diseases

Aliases & Classifications for Fetal Hydantoin Syndrome

MalaCards integrated aliases for Fetal Hydantoin Syndrome:

Name: Fetal Hydantoin Syndrome 53 59 55 73
Fetal Dihydantoin Syndrome 59
Phenytoin Embryofetopathy 59
Phenytoin Embryopathy 53
Dilantin Embryopathy 53

Characteristics:

Orphanet epidemiological data:

59
fetal hydantoin syndrome
Inheritance: Not applicable; Age of onset: Antenatal,Neonatal;

Classifications:



Summaries for Fetal Hydantoin Syndrome

NIH Rare Diseases : 53 Fetal hydantoin syndromeis a disorder that is caused by exposure of a fetus to phenytoin, a drug commonly prescribed for epilepsy. Not all infants exposed to phenytoin will be affected with the disorder. Symptoms in affected individuals may include abnormalities of the skull and facial features, growth deficiencies, underdeveloped nails of the fingers and toes, and/or mild developmental delays. Other findings occasionally associated with this syndrome include cleft lip and palate, having an abnormally small head (microcephaly) and brain malformations with more significant developmental delays. Treatment may include surgery for cleft lip and palate and special education and related services for children with learning delays. Other treatment is symptomatic and supportive.

MalaCards based summary : Fetal Hydantoin Syndrome, also known as fetal dihydantoin syndrome, is related to neuroblastoma and hemorrhagic disease. An important gene associated with Fetal Hydantoin Syndrome is EPHX2 (Epoxide Hydrolase 2). Affiliated tissues include brain, skin and heart, and related phenotypes are cryptorchidism and bifid scrotum

Wikipedia : 76 Fetal hydantoin syndrome, also called fetal dilantin syndrome is a group of defects caused to the... more...

Related Diseases for Fetal Hydantoin Syndrome

Diseases related to Fetal Hydantoin Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 neuroblastoma 10.1
2 hemorrhagic disease 10.0
3 polydactyly 9.9
4 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 9.9
5 heart disease 9.9
6 lymphangioma 9.9
7 melanotic neuroectodermal tumor 9.9
8 thrombocytosis 9.9
9 cystic lymphangioma 9.9
10 peritonitis 9.9
11 transposition of the great arteries 9.9
12 acheiria 9.9

Graphical network of the top 20 diseases related to Fetal Hydantoin Syndrome:



Diseases related to Fetal Hydantoin Syndrome

Symptoms & Phenotypes for Fetal Hydantoin Syndrome

Human phenotypes related to Fetal Hydantoin Syndrome:

59 32 (show all 30)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cryptorchidism 59 32 occasional (7.5%) Occasional (29-5%) HP:0000028
2 bifid scrotum 59 32 frequent (33%) Frequent (79-30%) HP:0000048
3 wide mouth 59 32 frequent (33%) Frequent (79-30%) HP:0000154
4 cleft palate 59 32 occasional (7.5%) Occasional (29-5%) HP:0000175
5 everted lower lip vermilion 59 32 frequent (33%) Frequent (79-30%) HP:0000232
6 abnormality of the fontanelles or cranial sutures 59 32 frequent (33%) Frequent (79-30%) HP:0000235
7 microcephaly 59 32 frequent (33%) Frequent (79-30%) HP:0000252
8 epicanthus 59 32 frequent (33%) Frequent (79-30%) HP:0000286
9 hypertelorism 59 32 frequent (33%) Frequent (79-30%) HP:0000316
10 hearing abnormality 59 32 hallmark (90%) Very frequent (99-80%) HP:0000364
11 low-set, posteriorly rotated ears 59 32 hallmark (90%) Very frequent (99-80%) HP:0000368
12 abnormality of the pinna 59 32 hallmark (90%) Very frequent (99-80%) HP:0000377
13 depressed nasal ridge 59 32 hallmark (90%) Very frequent (99-80%) HP:0000457
14 thickened nuchal skin fold 59 32 frequent (33%) Frequent (79-30%) HP:0000474
15 strabismus 59 32 frequent (33%) Frequent (79-30%) HP:0000486
16 ptosis 59 32 frequent (33%) Frequent (79-30%) HP:0000508
17 triphalangeal thumb 59 32 frequent (33%) Frequent (79-30%) HP:0001199
18 global developmental delay 59 32 frequent (33%) Frequent (79-30%) HP:0001263
19 intrauterine growth retardation 59 32 frequent (33%) Frequent (79-30%) HP:0001511
20 abnormality of the cardiovascular system 59 32 occasional (7.5%) Occasional (29-5%) HP:0001626
21 hypoplastic fingernail 59 32 frequent (33%) Frequent (79-30%) HP:0001804
22 low posterior hairline 59 32 frequent (33%) Frequent (79-30%) HP:0002162
23 coarse hair 59 32 frequent (33%) Frequent (79-30%) HP:0002208
24 neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0002664
25 short nose 59 32 hallmark (90%) Very frequent (99-80%) HP:0003196
26 short stature 59 32 frequent (33%) Frequent (79-30%) HP:0004322
27 wide intermamillary distance 59 32 frequent (33%) Frequent (79-30%) HP:0006610
28 abnormal dermatoglyphics 59 32 hallmark (90%) Very frequent (99-80%) HP:0007477
29 short distal phalanx of finger 59 32 frequent (33%) Frequent (79-30%) HP:0009882
30 hernia 59 32 frequent (33%) Frequent (79-30%) HP:0100790

Drugs & Therapeutics for Fetal Hydantoin Syndrome

Search Clinical Trials , NIH Clinical Center for Fetal Hydantoin Syndrome

Genetic Tests for Fetal Hydantoin Syndrome

Anatomical Context for Fetal Hydantoin Syndrome

MalaCards organs/tissues related to Fetal Hydantoin Syndrome:

41
Brain, Skin, Heart

Publications for Fetal Hydantoin Syndrome

Articles related to Fetal Hydantoin Syndrome:

(show top 50) (show all 63)
# Title Authors Year
1
Fetal Hydantoin Syndrome. ( 28578158 )
2017
2
Fetal hydantoin syndrome: A case report. ( 26838156 )
2016
3
Fetal hydantoin syndrome and its anaesthetic implications: a case report. ( 23082254 )
2012
4
Truncus arteriosus in fetal hydantoin syndrome - a new association? ( 12554926 )
2003
5
Transposition of the great arteries and hypocalcemia in a patient with fetal hydantoin syndrome. ( 11840251 )
2002
6
Fetal hydantoin syndrome with unilateral atypical cleft hand: additional evidence for vascular disruption. ( 12150216 )
2002
7
Pharmacokinetic data support pharmacologically induced embryonic dysrhythmia as explanation to Fetal Hydantoin Syndrome in rats. ( 10698674 )
2000
8
Fetal hydantoin syndrome with rheumatic valvular heart disease. ( 10798072 )
1999
9
Retro-peritoneal cystic lymphangioma in association with fetal hydantoin syndrome. ( 10798073 )
1999
10
Two siblings with fetal hydantoin syndrome. ( 9677735 )
1998
11
Fetal hydantoin syndrome: an unusual cause of hip dysplasia. ( 9507275 )
1998
12
Polydactyly and fetal hydantoin syndrome: an additional component of the syndrome? ( 9212184 )
1997
13
Phenytoin-mediated oxidative stress in serum of female epileptics: a possible pathogenesis in the fetal hydantoin syndrome. ( 9088972 )
1997
14
Hand anomalies in fetal-hydantoin syndrome: from nail/phalangeal hypoplasia to unilateral acheiria. ( 8723073 )
1996
15
Biochemical and molecular teratology of fetal hydantoin syndrome. ( 7845340 )
1994
16
Prenatal prediction of risk of the fetal hydantoin syndrome. ( 8232451 )
1993
17
Thrombocytosis and hyposplenism in an infant with fetal hydantoin syndrome. ( 1550265 )
1992
18
The fetal hydantoin syndrome. ( 1842240 )
1991
19
Prenatal prediction of risk of the fetal hydantoin syndrome. ( 2336087 )
1990
20
The fetal hydantoin syndrome: answers from a mouse model. ( 2520510 )
1989
21
Fetal hydantoin syndrome: a case report. ( 2501774 )
1989
22
Genetics and fetal hydantoin syndrome. ( 2493186 )
1989
23
Fetal hydantoin syndrome? ( 2704664 )
1989
24
Onychopathy in a patient with fetal hydantoin syndrome. ( 3380763 )
1988
25
Elevated glucocorticoid receptor levels in lymphocytes of children with the fetal hydantoin syndrome (FHS). ( 3425630 )
1987
26
Fetal hydantoin syndrome in rats: dose-effect relationships of prenatal phenytoin on postnatal development and behavior. ( 3629508 )
1987
27
Fetal hydantoin syndrome: inhibition of placental folic acid transport as a potential mechanism for fetal growth retardation in the rat. ( 3992032 )
1985
28
Fetal hydantoin syndrome and malignancy. ( 6481557 )
1984
29
Fetal hydantoin syndrome characteristics. ( 6507400 )
1984
30
Radiological case of the month. Fetal hydantoin syndrome. ( 6702795 )
1984
31
Genetic background: the elusive component in the fetal hydantoin syndrome. ( 6507492 )
1984
32
Fetal hydantoin syndrome. ( 6719170 )
1984
33
Variable patterns of malformation in the mouse fetal hydantoin syndrome. ( 6507493 )
1984
34
The Fetal Hydantoin Syndrome: a case report and review. ( 6843707 )
1983
35
Discordant expression of fetal hydantoin syndrome in heteropaternal dizygotic twins. ( 7088049 )
1982
36
Mouse fetal hydantoin syndrome: effects of maternal seizures. ( 7094908 )
1982
37
Subcutaneous vascular abnormalities in fetal hydantoin syndrome. ( 7126798 )
1982
38
Expanding phenotype of fetal hydantoin syndrome. ( 7099813 )
1982
39
Atypical fetal hydantoin syndrome. ( 7099812 )
1982
40
Decreased ornithine decarboxylase in the fetal hydantoin syndrome. ( 6178351 )
1982
41
Fetal hydantoin syndrome: current status. ( 7131169 )
1982
42
Fetal hydantoin syndrome. ( 7294852 )
1981
43
Ocular manifestations of the fetal hydantoin syndrome. ( 6786811 )
1981
44
Cancer in the fetal hydantoin syndrome. ( 6113474 )
1981
45
Picture of the month: fetal hydantoin syndrome. ( 7211801 )
1981
46
Melanotic neuroectodermal tumor of infancy and fetal hydantoin syndrome. ( 6263127 )
1981
47
The effects of phenytoin on rat development: an animal model system for fetal hydantoin syndrome. ( 7199765 )
1981
48
Hand abnormalities in the fetal hydantoin syndrome. ( 6453893 )
1981
49
Association of hemorrhagic disease and the syndrome of persistent fetal circulation with the fetal hydantoin syndrome. ( 7350289 )
1980
50
Fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease in a neonate. ( 7420637 )
1980

Variations for Fetal Hydantoin Syndrome

Expression for Fetal Hydantoin Syndrome

Search GEO for disease gene expression data for Fetal Hydantoin Syndrome.

Pathways for Fetal Hydantoin Syndrome

GO Terms for Fetal Hydantoin Syndrome

Sources for Fetal Hydantoin Syndrome

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74 UMLS via Orphanet
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