MCID: FTL021
MIFTS: 46

Fetal Macrosomia

Categories: Rare diseases, Fetal diseases

Aliases & Classifications for Fetal Macrosomia

MalaCards integrated aliases for Fetal Macrosomia:

Name: Fetal Macrosomia 53 55 73

Classifications:



External Ids:

UMLS 73 C0015938

Summaries for Fetal Macrosomia

MalaCards based summary : Fetal Macrosomia is related to gestational diabetes and diabetes mellitus. An important gene associated with Fetal Macrosomia is INS (Insulin), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Zinc and Metformin have been mentioned in the context of this disorder. Affiliated tissues include testes, fetal lung and ovary, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Fetal Macrosomia

Diseases related to Fetal Macrosomia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 gestational diabetes 30.4 INS INSR LEP
2 diabetes mellitus 28.5 APOA1 APOB IGF1 INS INSR LEP
3 insulin-like growth factor i 28.0 IGF1 IGF2 IGFBP3 INS INSR LEP
4 hyperinsulinism 27.7 APOB IGF1 IGFBP3 INS INSR LEP
5 diabetes mellitus, noninsulin-dependent 24.2 APOA1 APOB IGF1 IGF2 IGFBP3 INS
6 perlman syndrome 11.3
7 apo a-i deficiency 10.8 APOA1 LCAT
8 type 1 diabetes mellitus 2 10.8 IGF2 INS
9 hypoglycemic coma 10.8 IGF2 INS
10 insulin autoimmune syndrome 10.8 INS INSR
11 familial lcat deficiency 10.8 APOA1 LCAT
12 silver-russell syndrome due to an imprinting defect of 11p15 10.7 H19 IGF2
13 silver-russell syndrome due to 11p15 microduplication 10.7 H19 IGF2
14 beckwith-wiedemann syndrome due to imprinting defect of 11p15 10.7 H19 IGF2
15 slipped capital femoral epiphysis 10.7 IGF1 IGFBP3
16 hyperinsulinemic hypoglycemia, familial, 2 10.7 IGF2 INS
17 fish-eye disease 10.7 APOA1 LCAT
18 hemihyperplasia, isolated 10.6 H19 IGF2
19 pseudopapilledema 10.6 IGF1 IGF2
20 sheehan syndrome 10.6 IGF1 INS
21 pituitary adenoma 1, multiple types 10.6 IGF1 IGFBP3
22 diffuse idiopathic skeletal hyperostosis 10.6 IGF1 IGFBP3
23 central precocious puberty 10.6 IGF1 IGFBP3
24 defective apolipoprotein b-100 10.5 APOB LCAT
25 amyloidosis aa 10.5 APOA1 LCAT
26 rubeosis iridis 10.5 IGF1 IGF2 INS
27 hyperpituitarism 10.5 IGF1 IGFBP3 INS
28 mammographic density 10.5 IGF1 IGFBP3
29 isolated growth hormone deficiency, type ib 10.5 IGF1 IGFBP3
30 acid-labile subunit deficiency 10.5 IGF1 IGF2 IGFBP3
31 donohue syndrome 10.5 IGF1 INS INSR
32 hypopituitarism 10.4 IGF1 IGFBP3 INS
33 laron syndrome 10.4 IGF1 IGF2 IGFBP3
34 fasting hypoglycemia 10.4 IGF1 IGF2 INSR
35 leukodystrophy, hypomyelinating, 3 10.4 APOA1 APOB
36 hyperandrogenism 10.4 IGF1 INS INSR
37 ischemic heart disease 10.4 APOA1 APOB INS
38 lipoprotein glomerulopathy 10.4 APOB LCAT
39 hypertriglyceridemia, familial 10.4 APOA1 APOB INS
40 hepatoblastoma 10.4 APOA1 H19 IGF2
41 dysbaric osteonecrosis 10.3 APOA1 APOB
42 gallbladder disease 10.3 APOA1 APOB INS
43 hypobetalipoproteinemia, familial, 1 10.3 APOA1 APOB LCAT
44 hypolipoproteinemia 10.3 APOA1 APOB LCAT
45 hypoalphalipoproteinemia, primary 10.3 APOA1 APOB LCAT
46 hyperalphalipoproteinemia 1 10.3 APOA1 APOB LCAT
47 abetalipoproteinemia 10.3 APOA1 APOB LCAT
48 lecithin:cholesterol acyltransferase deficiency 10.3 APOA1 APOB LCAT
49 tangier disease 10.3 APOA1 APOB LCAT
50 arteriosclerosis 10.3 APOA1 APOB INS

Graphical network of the top 20 diseases related to Fetal Macrosomia:



Diseases related to Fetal Macrosomia

Symptoms & Phenotypes for Fetal Macrosomia

MGI Mouse Phenotypes related to Fetal Macrosomia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.15 IGF2 APOA1 IGFBP3 APOB APOM INS
2 cardiovascular system MP:0005385 10.13 LCAT APOA1 IGFBP3 APOB INS IGF1
3 endocrine/exocrine gland MP:0005379 10.06 IGF2 APOA1 IGFBP3 INS IGF1 INSR
4 adipose tissue MP:0005375 9.93 INSR IGFBP3 INS IGF1 LEP OXT
5 integument MP:0010771 9.87 IGF2 APOA1 IGFBP3 INS IGF1 LEP
6 liver/biliary system MP:0005370 9.86 LCAT APOA1 IGFBP3 APOB INS INSR
7 muscle MP:0005369 9.7 INSR IGF2 IGFBP3 APOB INS IGF1
8 renal/urinary system MP:0005367 9.56 LCAT IGFBP3 INS IGF1 INSR IGF2
9 reproductive system MP:0005389 9.28 IGF2 APOB APOM INS IGF1 INSR

Drugs & Therapeutics for Fetal Macrosomia

Drugs for Fetal Macrosomia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6 23994
2
Metformin Approved Phase 4,Phase 2,Phase 3,Not Applicable 657-24-9 14219 4091
3
Glyburide Approved Phase 4,Phase 3,Phase 2,Not Applicable 10238-21-8 3488
4 insulin Phase 4,Phase 2,Phase 3,Not Applicable
5 Hypoglycemic Agents Phase 4,Phase 2,Phase 3,Not Applicable
6 Insulin, Globin Zinc Phase 4,Phase 2,Phase 3,Not Applicable
7
Diazoxide Approved Phase 2, Phase 3 364-98-7 3019
8
Acarbose Approved, Investigational Phase 3 56180-94-0 441184
9
Lamivudine Approved, Investigational Phase 3 134678-17-4 60825
10
Abacavir Approved, Investigational Phase 3 136470-78-5 65140 441300
11 Dolutegravir Approved Phase 3 1051375-16-6 54726191
12 Vasodilator Agents Phase 2, Phase 3
13 Antihypertensive Agents Phase 2, Phase 3
14 Insulin, Isophane Phase 3,Not Applicable
15 Insulin, Short-Acting Phase 3,Not Applicable
16 Isophane insulin, beef Phase 3,Not Applicable
17 Isophane Insulin, Human Phase 3,Not Applicable
18 Glycoside Hydrolase Inhibitors Phase 3
19 Cardiac Glycosides Phase 3
20 Integrase Inhibitors Phase 3
21 Acidophilus Nutraceutical Phase 3,Not Applicable
22 Soy Bean Nutraceutical Phase 2, Phase 3
23 glucagon Phase 2
24 Gastrointestinal Agents Phase 2,Not Applicable
25 Glucagon-Like Peptide 1 Phase 2
26 Hormone Antagonists Phase 2,Not Applicable
27 Hormones Phase 2,Not Applicable
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Not Applicable
29 Incretins Phase 2
30
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
31
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
32
Insulin Aspart Approved Not Applicable 116094-23-6 16132418
33
Insulin Detemir Approved Not Applicable 169148-63-4 5311023
34
Magnesium citrate Approved Not Applicable 3344-18-1
35
Racepinephrine Approved Not Applicable 329-65-7 838
36
Menthol Approved Not Applicable 2216-51-5 16666
37
Modafinil Approved, Investigational 68693-11-8 4236
38
Insulin Glargine Approved Not Applicable 160337-95-1
39
Armodafinil Approved, Investigational 112111-43-0
40
Menotropins Approved Not Applicable 61489-71-2, 9002-68-0 5360545
41
Insulin Lispro Approved Not Applicable 133107-64-9
42
Zinc oxide Approved Not Applicable 1314-13-2
43
Exenatide Approved, Investigational 141758-74-9 15991534
44
leucovorin Approved, Nutraceutical ,Not Applicable 58-05-9 143 6006
45 tannic acid Approved, Nutraceutical Not Applicable
46
Folic Acid Approved, Nutraceutical, Vet_approved ,Not Applicable 59-30-3 6037
47
Blackberry Approved, Nutraceutical Not Applicable
48
Vitamin D Approved, Nutraceutical, Vet_approved Not Applicable 1406-16-2
49
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
50
Vitamin D3 Approved, Nutraceutical Not Applicable 67-97-0 6221 5280795

Interventional clinical trials:

(show top 50) (show all 161)
# Name Status NCT ID Phase Drugs
1 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4 Metformin;Glyburide
2 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
3 DAME: Induction of Labor or Waiting for Suspicion Fetal Macrosomia Completed NCT00190320 Phase 4
4 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
5 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4 Glyburide;Placebo
6 Threshold for Initiation of Medical Treatment for Women With Gestational Diabetes Not yet recruiting NCT03527537 Phase 4 Insulin;Glyburide;Metformin
7 Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes Withdrawn NCT00160485 Phase 4 Glyburide;Insulin
8 Diazoxide In the Management Of Hypoglycemic Neonates Unknown status NCT00994149 Phase 2, Phase 3 Diazoxide;Ora-plus
9 Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country Unknown status NCT01855763 Phase 2, Phase 3 Metformin;Insulin
10 Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy Unknown status NCT01436448 Phase 3 Probiotics Lactobacillus Rhamnosus
11 Metformin in Obese Non-diabetic Pregnant Women Completed NCT01273584 Phase 2, Phase 3 Metformin;Placebo
12 Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes Completed NCT01731431 Phase 3 Glyburide
13 Comparison of Metformin and Insulin for Management of Gestational Diabetes Mellitus Completed NCT03320694 Phase 3 Metformin;Insulin
14 Does Fish Oil Prevent Depression in Pregnancy and Postpartum? Completed NCT00711971 Phase 2, Phase 3 EPA-rich fish oil supplement;DHA-rich fish oil supplement;placebo
15 Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD) Recruiting NCT02932475 Phase 3 Metformin;Placebo
16 Metformin in Women With Type 2 Diabetes in Pregnancy Trial Recruiting NCT01353391 Phase 3 Metformin;Placebo Comparator
17 Effect of a Continuous Glucose Monitoring on Maternal and Neonatal Outcomes in Gestational Diabetes Mellitus Not yet recruiting NCT02838147 Phase 3
18 Pregnancy Outcomes: Effects of Metformin Study (POEM Study) Not yet recruiting NCT02947503 Phase 3 Metformin HCL 850 CF
19 Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus. Not yet recruiting NCT03380546 Phase 3 Acarbose;Prandial insulin
20 ING200336, Pharmacokinetic and Safety Study in Pregnant Women With Human Immuno Virus Infection Suspended NCT02075593 Phase 3 DTG 50 mg /ABC 600 mg /3TC 300 mg FDC tablets
21 Home Versus Hospital Care in Glucose Monitoring of Gestational Diabetes and Mild Gestational Hyperglycemia Completed NCT01441518 Phase 2
22 Glucagon in the Treatment of Hypoglycemia in Newborn Infants of Diabetic Mothers Completed NCT00434772 Phase 2 glucagon
23 Impact of Diet and Exercise Activity on Pregnancy Outcomes Recruiting NCT00486629 Phase 2
24 An Early-customized Low Glycaemic-index (GI) Diet Prevents LGA Babies in Overweight/Obese Pregnant Women Unknown status NCT02750774 Not Applicable
25 Fish Oil Supplementation in Women With Gestational Diabetes Unknown status NCT02371343 Not Applicable
26 Diet and Physical Activity Counseling and n3-long Chain (PUFA) Supplementation in Obese Pregnant Women Unknown status NCT02574767 Not Applicable
27 Weight Gain During Pregnancy - a Randomized Controlled Trial of Intervention to Prevent Excessive Gestational Weight Gain Unknown status NCT00451425 Not Applicable
28 Postprandial Walking in Obese Pregnant Women and Perinatal Outcomes - a Multicenter Randomized Clinical Trial Unknown status NCT02180152 Not Applicable
29 Effect of Psycho-education on Gestational Weight Gain and Anxiety/Depression in Obese Pregnant Women Unknown status NCT01329835 Not Applicable
30 Lipophilic Micronutrients, Adipokines and Gestational Diabetes Mellitus Unknown status NCT01678469 Not Applicable
31 Vaspin Levels Compared With Serum Insulin and Blood Glucose Levels in Neonates Unknown status NCT01363622
32 Myo-inositol, D-chiro-inositol, and D-chiro/Myo-inositol in Gestational Diabetes Unknown status NCT01762826
33 Pregnancy Complications in Women With BMI>25 kg/m2 Enrolled in a Healthy Lifestyle and Eating Habits Program Unknown status NCT01783210 Not Applicable
34 Inositol Stereoisomers to Treat Gestational Diabetes Unknown status NCT02097069 Not Applicable
35 Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes Unknown status NCT00678080 Not Applicable Metformin;Insulin (NPH and Regular)
36 Managing Diabetes During Pregnancy in the Wireless Age Unknown status NCT01474525 Not Applicable
37 The Role of Umbilical Cord Thickness in Prediction of Fetal Macrosomia in Patients With Gestational Diabetes Mellitus Completed NCT02643225
38 The DNA Methylation of ARHGEF11 in Macrosomia Completed NCT03165643
39 Fetal Front-abdominal Wall Thickness and Perinatal Outcome Completed NCT03232294
40 Breast Milk Zinc Transfer to Appropriate- and Small-for-gestational-age Bangladeshi Infants Completed NCT01728766
41 Treatment of Impaired Glucose Tolerance in Pregnancy Completed NCT00625781 Not Applicable Insulin aspart and Insulin human (isophane)
42 Randomized Translational Study to Examine the Effects of Shared Care in Management of Gestational Diabetes Completed NCT01565564 Not Applicable
43 Weight Management for Improved Pregnancy Outcomes Completed NCT00950235 Not Applicable
44 Meal Composition and the Influence on Pre-prandial Blood Glucose Values Completed NCT03028506
45 Correlation Between Placental Thickness in the Second and Third Trimester and Fetal Weight Completed NCT02473991
46 Lifestyle Intervention and Prevention of Gestational Diabetes Mellitus Completed NCT02368600 Not Applicable
47 Preventing Childhood Obesity: A Two-pronged Approach Starting in Pregnancy and the First Year Postpartum Completed NCT01129505 Not Applicable
48 Frequency of Blood Glucose Monitoring in Patients With Gestational Diabetes Completed NCT01818557 Not Applicable
49 Exploration of the Lipid Metabolism During the Diabetic Pregnancies Completed NCT00639964 Not Applicable
50 Improve Detection and Management of Gestational Diabetes Through the Primary Health Care Level in Morocco Completed NCT02979756 Not Applicable

Search NIH Clinical Center for Fetal Macrosomia

Genetic Tests for Fetal Macrosomia

Anatomical Context for Fetal Macrosomia

MalaCards organs/tissues related to Fetal Macrosomia:

41
Testes, Fetal Lung, Ovary, Breast, Thyroid, Bone, Lung

Publications for Fetal Macrosomia

Articles related to Fetal Macrosomia:

(show top 50) (show all 206)
# Title Authors Year
1
Level of maternal triglycerides is a predictor of fetal macrosomia in non-obese pregnant women with gestational diabetes mellitus. ( 29398554 )
2018
2
Correlation between plasma ferritin level and gestational diabetes mellitus and its impact on fetal macrosomia. ( 29542249 )
2018
3
ARHGEF11 affecting the placental insulin signaling pathway in fetal macrosomia of normal glucose tolerance pregnant women. ( 29486856 )
2018
4
Vacuum extraction in fetal macrosomia: registry data are useful. ( 28117885 )
2017
5
Induction of labour at 37 weeks for suspected fetal macrosomia may reduce birth trauma. ( 28646127 )
2017
6
Correlation of placental microbiota with fetal macrosomia and clinical characteristics in mothers and newborns. ( 29137266 )
2017
7
Potential prognostic biomarkers of cardiovascular disease in fetal macrosomia: the impact of gestational diabetes. ( 28298172 )
2017
8
Measurement and evaluation of fetal fat layer in the prediction of fetal macrosomia in pregnancies complicated by gestational diabetes. ( 28631075 )
2017
9
Frequency of fetal macrosomia and the associated risk factors in pregnancies without gestational diabetes mellitus. ( 28451039 )
2017
10
Third trimester ultrasound for fetal macrosomia: optimal timing and institutional specific accuracy. ( 29183184 )
2017
11
Associated outcomes to fetal macrosomia: effect of maternal diabetes. ( 29424871 )
2017
12
Morbidity Associated with Fetal Macrosomia among Women with Diabetes Mellitus. ( 29183096 )
2017
13
AN ERUPTION PATTERN OF DECIDUOUS TEETH IN CHILDREN BORN WITH FETAL MACROSOMIA DURING THE FIRST YEAR OF LIFE. ( 28452722 )
2017
14
Induction of labour at or near term for suspected fetal macrosomia. ( 27208913 )
2016
15
Practice Bulletin No. 173 Summary: Fetal Macrosomia. ( 27776066 )
2016
16
Vacuum extraction in fetal macrosomia and risk of neonatal complications: a population-based cohort study. ( 27472147 )
2016
17
Peptidome profiling of umbilical cord plasma associated with gestational diabetes-induced fetal macrosomia. ( 26945739 )
2016
18
Amniotic fluid index and estimated fetal weight for prediction of fetal macrosomia: a prospective observational study. ( 27596358 )
2016
19
Induction of labour for fetal macrosomia: do we finally have an answer? ( 27921388 )
2016
20
Fetal macrosomia as a risk factor for shoulder dystocia during vacuum extraction. ( 27549142 )
2016
21
Gestational diabetes: Glycaemic predictors for fetal macrosomia and maternal risk of future diabetes. ( 26818892 )
2016
22
Risk factors and outcomes of fetal macrosomia in a tertiary centre in Tanzania: a case-control study. ( 27557930 )
2016
23
Induction of labour for suspected fetal macrosomia, Boulvain et al (2016). ( 27652444 )
2016
24
Comparison of 2- and 3-Dimensional Sonography for Estimation of Birth Weight and Neonatal Adiposity in the Setting of Suspected Fetal Macrosomia. ( 27091915 )
2016
25
Practice Bulletin No. 173: Fetal Macrosomia. ( 27776071 )
2016
26
Fetal macrosomia: induction of labour or expectant management? ( 26595633 )
2015
27
Effect of Personalized Nutrition Guidance on the Birth Rate of Fetal Macrosomia in Chinese Population: A Meta-analysis of Nine Randomized Controlled Trials. ( 27352186 )
2015
28
Determinants and outcome of fetal macrosomia in a Nigerian tertiary hospital. ( 26903699 )
2015
29
Does fetal macrosomia affect umbilical artery Doppler velocity waveforms in pregnancies complicated by gestational diabetes? ( 26699801 )
2015
30
Low cord blood serum levels of vitamin D: cause or effect of fetal macrosomia? ( 26411220 )
2015
31
The Effects of Prepregnancy Body Mass Index and Gestational Weight Gain on Fetal Macrosomia Among American Indian/Alaska Native Women. ( 26122253 )
2015
32
Fetal macrosomia: induction of labour or expectant management? ( 26595636 )
2015
33
An Evidence-Based Approach to Defining Fetal Macrosomia. ( 26499356 )
2015
34
Fetal macrosomia: induction of labour or expectant management? ( 26595635 )
2015
35
Weight gain in pregnancy, maternal age and gestational age in relation to fetal macrosomia. ( 25954731 )
2015
36
Cord blood copeptin concentrations in fetal macrosomia. ( 26477270 )
2015
37
Fetal macrosomia: induction of labour or expectant management? - Authors' reply. ( 26595634 )
2015
38
Physical activity, sedentary behaviour and fetal macrosomia in uncomplicated pregnancies: A prospective cohort study. ( 24861673 )
2014
39
Maternal obesity and occurrence of fetal macrosomia: a systematic review and meta-analysis. ( 25544943 )
2014
40
Counseling for Fetal Macrosomia: An Estimated Fetal Weight of 4,000a88g is Excessively Low. ( 24839149 )
2014
41
Differential expression of circulating miRNAs in maternal plasma in pregnancies with fetal macrosomia. ( 25370776 )
2014
42
Fetal macrosomia: a problem in need of a policy. ( 24395685 )
2014
43
Third trimester insulin levels are not correlated with fetal macrosomia or delivery complications. ( 24937972 )
2014
44
Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. ( 25231897 )
2014
45
Increased mRNA levels of apolipoprotein M and apolipoprotein AI in the placental tissues with fetal macrosomia. ( 25194312 )
2014
46
Estimate of fetal weight by ultrasound within two weeks of delivery in the detection of fetal macrosomia. ( 24773582 )
2014
47
Amniotic fluid insulin and C-peptide as predictive markers for fetal macrosomia, birth injuries, and delivery complications? ( 24423633 )
2014
48
Sonographic weight estimation in fetal macrosomia: influence of the time interval between estimation and delivery. ( 25534163 )
2014
49
The combined effect of maternal obesity and fetal macrosomia on pregnancy outcomes. ( 25222356 )
2014
50
Is fetal macrosomia related to blood pressure among adolescents? A birth cohort study in China. ( 23595162 )
2013

Variations for Fetal Macrosomia

Expression for Fetal Macrosomia

Search GEO for disease gene expression data for Fetal Macrosomia.

Pathways for Fetal Macrosomia

Pathways related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 APOA1 APOB APOM SLC2A3
2
Show member pathways
12.12 IGF1 INS INSR LEP
3
Show member pathways
12 APOA1 APOB INS INSR
4
Show member pathways
11.91 IGF1 INS INSR
5
Show member pathways
11.84 IGF1 INS INSR
6 11.81 IGF1 INS LEP
7
Show member pathways
11.77 IGF1 IGF2 IGFBP3
8
Show member pathways
11.73 APOA1 APOB LCAT
9 11.66 IGF1 IGFBP3 INS
10 11.61 IGF1 INS INSR
11 11.22 IGF1 IGF2 INS
12 11.13 INS INSR LEP
13 11.02 IGF1 INS INSR
14 10.95 APOA1 APOB
15 10.89 INSR LEP
16 10.7 IGF1 INS INSR
17 10.12 IGF1 IGF2 IGFBP3

GO Terms for Fetal Macrosomia

Cellular components related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.81 APOA1 APOB IGFBP3 INS
2 extracellular space GO:0005615 9.65 APOA1 APOB APOM IGF1 IGF2 IGFBP3
3 endosome lumen GO:0031904 9.55 APOB INS
4 endocytic vesicle lumen GO:0071682 9.54 APOA1 APOB
5 chylomicron GO:0042627 9.52 APOA1 APOB
6 high-density lipoprotein particle GO:0034364 9.5 APOA1 APOM LCAT
7 spherical high-density lipoprotein particle GO:0034366 9.49 APOA1 APOM
8 intermediate-density lipoprotein particle GO:0034363 9.46 APOA1 APOB
9 insulin-like growth factor ternary complex GO:0042567 9.43 IGF1 IGFBP3
10 very-low-density lipoprotein particle GO:0034361 9.43 APOA1 APOB APOM
11 discoidal high-density lipoprotein particle GO:0034365 9.4 APOA1 APOM
12 insulin-like growth factor binding protein complex GO:0016942 9.37 IGF1 IGFBP3
13 extracellular region GO:0005576 9.36 APOA1 APOB APOM IGF1 IGF2 IGFBP3
14 low-density lipoprotein particle GO:0034362 9.33 APOA1 APOB APOM
15 extracellular exosome GO:0070062 10.13 APOA1 APOB APOM IGF2 IGFBP3 INSR

Biological processes related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.97 IGF2 INS INSR PGM1 SLC2A3
2 positive regulation of protein kinase B signaling GO:0051897 9.93 IGF2 INS INSR LEP
3 activation of MAPK activity GO:0000187 9.91 IGF1 IGF2 INS INSR
4 lipid transport GO:0006869 9.89 APOA1 APOB APOM
5 platelet degranulation GO:0002576 9.88 APOA1 IGF1 IGF2
6 steroid metabolic process GO:0008202 9.88 APOA1 APOB LCAT
7 response to organic substance GO:0010033 9.88 APOB IGF1 IGF2 INS
8 response to estradiol GO:0032355 9.87 APOB LEP OXT
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.87 IGF1 IGF2 INS
10 cholesterol metabolic process GO:0008203 9.87 APOA1 APOB LCAT LEP
11 insulin receptor signaling pathway GO:0008286 9.86 IGF2 INS INSR
12 cholesterol homeostasis GO:0042632 9.85 APOA1 APOB APOM LCAT
13 retinoid metabolic process GO:0001523 9.84 APOA1 APOB APOM
14 response to glucose GO:0009749 9.81 APOM IGF1 IGF2 INS
15 positive regulation of DNA replication GO:0045740 9.8 IGF1 INS INSR
16 activation of protein kinase B activity GO:0032148 9.8 IGF1 INS INSR
17 response to insulin GO:0032868 9.8 IGF1 IGF2 INS LEP
18 cellular protein metabolic process GO:0044267 9.8 APOA1 APOB IGF1 IGF2 IGFBP3 INS
19 positive regulation of glucose import GO:0046326 9.79 IGF1 INS INSR
20 cholesterol transport GO:0030301 9.78 APOA1 APOB LCAT
21 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.78 IGF1 IGF2 INS LEP
22 cholesterol efflux GO:0033344 9.77 APOA1 APOB APOM
23 lipoprotein metabolic process GO:0042157 9.77 APOA1 APOB APOM
24 glucose homeostasis GO:0042593 9.77 IGF1 IGF2 INS INSR LEP
25 glucose metabolic process GO:0006006 9.76 IGF2 INS LEP PGM1
26 positive regulation of glycolytic process GO:0045821 9.73 IGF1 INS INSR
27 response to nutrient levels GO:0031667 9.73 IGF1 IGF2 INS LEP
28 adrenal gland development GO:0030325 9.71 APOA1 INSR
29 reverse cholesterol transport GO:0043691 9.71 APOA1 APOM LCAT
30 positive regulation of lipid biosynthetic process GO:0046889 9.7 APOA1 INS
31 phosphatidylcholine metabolic process GO:0046470 9.7 APOA1 LCAT
32 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.7 IGF1 IGFBP3
33 high-density lipoprotein particle remodeling GO:0034375 9.7 APOA1 APOM LCAT
34 high-density lipoprotein particle assembly GO:0034380 9.69 APOA1 APOM
35 chylomicron assembly GO:0034378 9.69 APOA1 APOB
36 very-low-density lipoprotein particle remodeling GO:0034372 9.68 APOA1 LCAT
37 high-density lipoprotein particle clearance GO:0034384 9.68 APOA1 APOM
38 chylomicron remodeling GO:0034371 9.67 APOA1 APOB
39 exocrine pancreas development GO:0031017 9.67 IGF2 INSR
40 positive regulation of respiratory burst GO:0060267 9.66 INS INSR
41 neuron projection maintenance GO:1990535 9.65 INS INSR
42 regulation of intestinal cholesterol absorption GO:0030300 9.65 APOA1 LEP
43 bone mineralization involved in bone maturation GO:0035630 9.64 IGF1 LEP
44 positive regulation of developmental growth GO:0048639 9.64 INSR LEP
45 lipoprotein biosynthetic process GO:0042158 9.58 APOA1 APOB LCAT
46 positive regulation of mitotic nuclear division GO:0045840 9.56 IGF1 IGF2 INS INSR
47 positive regulation of insulin receptor signaling pathway GO:0046628 9.46 IGF1 IGF2 INS LEP
48 positive regulation of MAPK cascade GO:0043410 9.43 IGF1 IGF2 IGFBP3 INS INSR LEP
49 positive regulation of glycogen biosynthetic process GO:0045725 8.92 IGF1 IGF2 INS INSR
50 negative regulation of apoptotic process GO:0043066 10.08 IGF1 IGF2 INS INSR LEP

Molecular functions related to Fetal Macrosomia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.61 APOA1 APOB APOM
2 hormone activity GO:0005179 9.55 IGF1 IGF2 INS LEP OXT
3 lipid transporter activity GO:0005319 9.5 APOA1 APOB APOM
4 cholesterol transporter activity GO:0017127 9.46 APOA1 APOB
5 insulin receptor binding GO:0005158 9.43 IGF1 IGF2 INS
6 insulin-like growth factor I binding GO:0031994 9.4 IGFBP3 INSR
7 insulin-like growth factor II binding GO:0031995 9.37 IGFBP3 INSR
8 receptor activator activity GO:0030546 9.13 IGF1 IGF2 INS
9 insulin-like growth factor receptor binding GO:0005159 8.92 IGF1 IGF2 INS INSR

Sources for Fetal Macrosomia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....