MCID: FTL021
MIFTS: 46

Fetal Macrosomia

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Fetal Macrosomia

MalaCards integrated aliases for Fetal Macrosomia:

Name: Fetal Macrosomia 53 55 73

Classifications:



External Ids:

UMLS 73 C0015938

Summaries for Fetal Macrosomia

MalaCards based summary : Fetal Macrosomia is related to gestational diabetes and diabetes mellitus. An important gene associated with Fetal Macrosomia is INS (Insulin), and among its related pathways/superpathways are Ras signaling pathway and Metabolism of water-soluble vitamins and cofactors. The drugs Glyburide and Metformin have been mentioned in the context of this disorder. Affiliated tissues include placenta, kidney and liver, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 76 Large for gestational age (LGA) is an indication of high prenatal growth... more...

Related Diseases for Fetal Macrosomia

Diseases related to Fetal Macrosomia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 gestational diabetes 30.8 INS INSR LEP
2 diabetes mellitus 30.1 APOA1 APOB IGF1 INS INSR LEP
3 hyperinsulinemic hypoglycemia 30.1 IGF2 INS INSR
4 insulin-like growth factor i 29.2 IGF1 IGF2 IGFBP3 INS INSR LEP
5 hyperinsulinism 29.2 APOB IGF1 IGFBP3 INS INSR LEP
6 perlman syndrome 11.4
7 apo a-i deficiency 10.3 APOA1 LCAT
8 silver-russell syndrome due to an imprinting defect of 11p15 10.3 H19 IGF2
9 silver-russell syndrome due to 11p15 microduplication 10.3 H19 IGF2
10 type 1 diabetes mellitus 2 10.3 IGF2 INS
11 beckwith-wiedemann syndrome due to imprinting defect of 11p15 10.3 H19 IGF2
12 hypoglycemic coma 10.3 IGF2 INS
13 familial lcat deficiency 10.2 APOA1 LCAT
14 hemihyperplasia, isolated 10.2 H19 IGF2
15 insulinomatosis and diabetes mellitus 10.2 IGF2 INS
16 fish-eye disease 10.2 APOA1 LCAT
17 defective apolipoprotein b-100 10.2 APOB LCAT
18 hypoglycemia 10.2
19 pseudopapilledema 10.2 IGF1 IGF2
20 sheehan syndrome 10.2 IGF1 INS
21 leukodystrophy, hypomyelinating, 3 10.2 APOA1 APOB
22 hyperlipoproteinemia, type v 10.2 APOA1 APOB INS
23 lipoprotein glomerulopathy 10.2 APOB LCAT
24 amyloidosis aa 10.2 APOA1 LCAT
25 beckwith-wiedemann syndrome 10.2 H19 IGF2 INS
26 hypertriglyceridemia, familial 10.2 APOA1 APOB INS
27 slipped capital femoral epiphysis 10.2 IGF1 IGFBP3
28 hyperlipidemia, familial combined 10.2 APOA1 APOB
29 gallbladder disease 10.2 APOA1 APOB INS
30 hypolipoproteinemia 10.2 APOA1 APOB LCAT
31 hypoalphalipoproteinemia, primary 10.2 APOA1 APOB LCAT
32 hyperalphalipoproteinemia 1 10.1 APOA1 APOB LCAT
33 rubeosis iridis 10.1 IGF1 IGF2 INS
34 hepatoblastoma 10.1 APOA1 H19 IGF2
35 lecithin:cholesterol acyltransferase deficiency 10.1 APOA1 APOB LCAT
36 abetalipoproteinemia 10.1 APOA1 APOB LCAT
37 tangier disease 10.1 APOA1 APOB LCAT
38 diffuse idiopathic skeletal hyperostosis 10.1 IGF1 IGFBP3
39 arteriosclerosis 10.1 APOA1 APOB INS
40 cerebrovascular disease 10.1 APOA1 APOB INS
41 body mass index quantitative trait locus 1 10.1
42 marasmus 10.1 IGF1 IGFBP3
43 hyperpituitarism 10.1 IGF1 IGFBP3 INS
44 mammographic density 10.1 IGF1 IGFBP3
45 sea-blue histiocyte disease 10.1 APOB LCAT
46 acid-labile subunit deficiency 10.1 IGF1 IGF2 IGFBP3
47 donohue syndrome 10.1 IGF1 INS INSR
48 hypopituitarism 10.1 IGF1 IGFBP3 INS
49 laron syndrome 10.1 IGF1 IGF2 IGFBP3
50 familial hyperlipidemia 10.1 APOA1 APOB INS LCAT

Graphical network of the top 20 diseases related to Fetal Macrosomia:



Diseases related to Fetal Macrosomia

Symptoms & Phenotypes for Fetal Macrosomia

MGI Mouse Phenotypes related to Fetal Macrosomia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.15 APOA1 APOB APOM IGF1 IGF2 IGFBP3
2 cardiovascular system MP:0005385 10.13 APOA1 APOB IGF1 IGF2 IGFBP3 INS
3 endocrine/exocrine gland MP:0005379 10.06 APOA1 IGF1 IGF2 IGFBP3 INS INSR
4 adipose tissue MP:0005375 9.93 IGF1 IGFBP3 INS INSR LEP OXT
5 integument MP:0010771 9.87 APOA1 IGF1 IGF2 IGFBP3 INS LEP
6 liver/biliary system MP:0005370 9.86 APOA1 APOB IGF2 IGFBP3 INS INSR
7 muscle MP:0005369 9.7 APOB IGF1 IGF2 IGFBP3 INS INSR
8 renal/urinary system MP:0005367 9.56 IGF1 IGF2 IGFBP3 INS INSR LCAT
9 reproductive system MP:0005389 9.28 APOB APOM IGF1 IGF2 INS INSR

Drugs & Therapeutics for Fetal Macrosomia

Drugs for Fetal Macrosomia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 118)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 4,Phase 3,Phase 2,Not Applicable 10238-21-8 3488
2
Metformin Approved Phase 4,Phase 2,Phase 3,Not Applicable 657-24-9 14219 4091
3
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6
4
Insulin Detemir Approved Phase 4,Not Applicable 169148-63-4 5311023
5
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
6 Hypoglycemic Agents Phase 4,Phase 2,Phase 3,Not Applicable
7 Insulin, Globin Zinc Phase 4,Phase 2,Phase 3,Not Applicable
8 insulin Phase 4,Phase 2,Phase 3,Not Applicable
9 Protamines Phase 4
10 calcium heparin Phase 4
11 Coagulants Phase 4
12
Diazoxide Approved Phase 2, Phase 3 364-98-7 3019
13
Acarbose Approved, Investigational Phase 3 56180-94-0 441184
14
Lamivudine Approved, Investigational Phase 3 134678-17-4 60825
15 Dolutegravir Approved Phase 3 1051375-16-6 54726191
16
Abacavir Approved, Investigational Phase 3 136470-78-5 65140 441300
17 Antihypertensive Agents Phase 2, Phase 3
18 Vasodilator Agents Phase 2, Phase 3
19 Acidophilus Phase 3,Not Applicable
20 Isophane Insulin, Human Phase 3,Not Applicable
21 Insulin, Isophane Phase 3,Not Applicable
22 Isophane insulin, beef Phase 3,Not Applicable
23 Soy Bean Phase 2, Phase 3
24 Insulin, Short-Acting Phase 3,Not Applicable
25 Cardiac Glycosides Phase 3
26 Glycoside Hydrolase Inhibitors Phase 3
27 Integrase Inhibitors Phase 3
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Not Applicable
29 Incretins Phase 2
30 glucagon Phase 2
31 Gastrointestinal Agents Phase 2,Not Applicable
32 Hormones Phase 2,Not Applicable
33 Hormone Antagonists Phase 2,Not Applicable
34 Glucagon-Like Peptide 1 Phase 2
35
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
36 tannic acid Approved Not Applicable
37
Mecasermin Approved, Investigational Not Applicable 68562-41-4
38
leucovorin Approved ,Not Applicable 58-05-9 6006 143
39
Blackberry Approved Not Applicable
40
Insulin Aspart Approved Not Applicable 116094-23-6 16132418
41
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
42
Racepinephrine Approved Not Applicable 329-65-7 838
43
Magnesium citrate Approved Not Applicable 3344-18-1
44
Zinc oxide Approved Not Applicable 1314-13-2
45
Insulin Glargine Approved Not Applicable 160337-95-1
46
Insulin Lispro Approved Not Applicable 133107-64-9
47
Armodafinil Approved, Investigational 112111-43-0
48
Modafinil Approved, Investigational 68693-11-8 4236
49
Menotropins Approved Not Applicable 61489-71-2, 9002-68-0 5360545
50
Ethiodized oil Approved, Investigational 8008-53-5

Interventional clinical trials:

(show top 50) (show all 177)
# Name Status NCT ID Phase Drugs
1 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4 Metformin;Glyburide
2 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
3 DAME: Induction of Labor or Waiting for Suspicion Fetal Macrosomia Completed NCT00190320 Phase 4
4 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
5 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4 Glyburide;Placebo
6 Detemir Versus NPH for Type 2 Diabetes Mellitus in Pregnancy Recruiting NCT03620890 Phase 4 Neutral Protamine Hagedorn (NPH);Detemir insulin
7 Threshold for Initiation of Medical Treatment for Women With Gestational Diabetes Not yet recruiting NCT03527537 Phase 4 Insulin;Glyburide;Metformin
8 Metformin Use to Improve Pregnancy Outcome in Women With Type 1 Diabetes. Not yet recruiting NCT03765359 Phase 4 metforminhydrochloride;Placebo Oral Tablet
9 Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes Withdrawn NCT00160485 Phase 4 Glyburide;Insulin
10 Diazoxide In the Management Of Hypoglycemic Neonates Unknown status NCT00994149 Phase 2, Phase 3 Diazoxide;Ora-plus
11 Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country Unknown status NCT01855763 Phase 2, Phase 3 Metformin;Insulin
12 Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy Unknown status NCT01436448 Phase 3 Probiotics Lactobacillus Rhamnosus
13 Metformin in Obese Non-diabetic Pregnant Women Completed NCT01273584 Phase 2, Phase 3 Metformin;Placebo
14 Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes Completed NCT01731431 Phase 3 Glyburide
15 Comparison of Metformin and Insulin for Management of Gestational Diabetes Mellitus Completed NCT03320694 Phase 3 Metformin;Insulin
16 Does Fish Oil Prevent Depression in Pregnancy and Postpartum? Completed NCT00711971 Phase 2, Phase 3 EPA-rich fish oil supplement;DHA-rich fish oil supplement;placebo
17 Randomization of Early Diabetes Screening Among Obese Pregnant Women. Recruiting NCT03116009 Phase 3 Screening for diabetes with 1-hour GCT and HbA1
18 Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus. Recruiting NCT03380546 Phase 3 Acarbose;Prandial insulin
19 Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD) Recruiting NCT02932475 Phase 3 Metformin;Placebo
20 Metformin in Women With Type 2 Diabetes in Pregnancy Trial Active, not recruiting NCT01353391 Phase 3 Metformin;Placebo Comparator
21 Effect of a Continuous Glucose Monitoring on Maternal and Neonatal Outcomes in Gestational Diabetes Mellitus Not yet recruiting NCT02838147 Phase 3
22 Pregnancy Outcomes: Effects of Metformin Study (POEM Study) Not yet recruiting NCT02947503 Phase 3 Metformin HCL 850 CF
23 ING200336, Pharmacokinetic and Safety Study in Pregnant Women With Human Immuno Virus Infection Suspended NCT02075593 Phase 3 DTG 50 mg /ABC 600 mg /3TC 300 mg FDC tablets
24 Home Versus Hospital Care in Glucose Monitoring of Gestational Diabetes and Mild Gestational Hyperglycemia Completed NCT01441518 Phase 2
25 Glucagon in the Treatment of Hypoglycemia in Newborn Infants of Diabetic Mothers Completed NCT00434772 Phase 2 glucagon
26 Impact of Diet and Exercise Activity on Pregnancy Outcomes Recruiting NCT00486629 Phase 2
27 An Early-customized Low Glycaemic-index (GI) Diet Prevents LGA Babies in Overweight/Obese Pregnant Women Unknown status NCT02750774 Not Applicable
28 Fish Oil Supplementation in Women With Gestational Diabetes Unknown status NCT02371343 Not Applicable
29 Diet and Physical Activity Counseling and n3-long Chain (PUFA) Supplementation in Obese Pregnant Women Unknown status NCT02574767 Not Applicable
30 Weight Gain During Pregnancy - a Randomized Controlled Trial of Intervention to Prevent Excessive Gestational Weight Gain Unknown status NCT00451425 Not Applicable
31 Postprandial Walking in Obese Pregnant Women and Perinatal Outcomes - a Multicenter Randomized Clinical Trial Unknown status NCT02180152 Not Applicable
32 Effect of Psycho-education on Gestational Weight Gain and Anxiety/Depression in Obese Pregnant Women Unknown status NCT01329835 Not Applicable
33 Lipophilic Micronutrients, Adipokines and Gestational Diabetes Mellitus Unknown status NCT01678469 Not Applicable
34 Vaspin Levels Compared With Serum Insulin and Blood Glucose Levels in Neonates Unknown status NCT01363622
35 The Establish of Specific Reference Ranges for Thyroid Tests in Pregnant Women Unknown status NCT02966405
36 Assessment of Patient Satisfaction Program "Gestational Diabetes" Unknown status NCT02945540
37 Myo-inositol, D-chiro-inositol, and D-chiro/Myo-inositol in Gestational Diabetes Unknown status NCT01762826
38 Effects of an Aquatic Physical Exercise Program on Glycaemic Control and Perinatal Outcomes of Gestational Diabetes: Study Protocol for a Randomized Controlled Trial Unknown status NCT01940003 Not Applicable
39 Pregnancy Complications in Women With BMI>25 kg/m2 Enrolled in a Healthy Lifestyle and Eating Habits Program Unknown status NCT01783210 Not Applicable
40 Inositol Stereoisomers to Treat Gestational Diabetes Unknown status NCT02097069 Not Applicable
41 bAriatric sUrgery Registration in wOmen of Reproductive Age Unknown status NCT02515214
42 Managing Diabetes During Pregnancy in the Wireless Age Unknown status NCT01474525 Not Applicable
43 The Role of Umbilical Cord Thickness in Prediction of Fetal Macrosomia in Patients With Gestational Diabetes Mellitus Completed NCT02643225
44 The DNA Methylation of ARHGEF11 in Macrosomia Completed NCT03165643
45 Fetal Front-abdominal Wall Thickness and Perinatal Outcome Completed NCT03232294
46 Breast Milk Zinc Transfer to Appropriate- and Small-for-gestational-age Bangladeshi Infants Completed NCT01728766
47 Treatment of Impaired Glucose Tolerance in Pregnancy Completed NCT00625781 Not Applicable Insulin aspart and Insulin human (isophane)
48 Incentives Targeting Gestational Weight Gain in Overweight/Obese Low Income Women Completed NCT02233673 Not Applicable
49 Randomized Translational Study to Examine the Effects of Shared Care in Management of Gestational Diabetes Completed NCT01565564 Not Applicable
50 Weight Management for Improved Pregnancy Outcomes Completed NCT00950235 Not Applicable

Search NIH Clinical Center for Fetal Macrosomia

Genetic Tests for Fetal Macrosomia

Anatomical Context for Fetal Macrosomia

MalaCards organs/tissues related to Fetal Macrosomia:

41
Placenta, Kidney, Liver, Heart, Eye, Breast, Pancreas

Publications for Fetal Macrosomia

Articles related to Fetal Macrosomia:

(show top 50) (show all 212)
# Title Authors Year
1
Level of maternal triglycerides is a predictor of fetal macrosomia in non-obese pregnant women with gestational diabetes mellitus. ( 29398554 )
2018
2
Correlation between plasma ferritin level and gestational diabetes mellitus and its impact on fetal macrosomia. ( 29542249 )
2018
3
ARHGEF11 affecting the placental insulin signaling pathway in fetal macrosomia of normal glucose tolerance pregnant women. ( 29486856 )
2018
4
Magnitude of fetal macrosomia and its associated factors at public health institutions of Hawassa city, southern Ethiopia. ( 30545390 )
2018
5
Vacuum extraction in fetal macrosomia: registry data are useful. ( 28117885 )
2017
6
Induction of labour at 37 weeks for suspected fetal macrosomia may reduce birth trauma. ( 28646127 )
2017
7
Correlation of placental microbiota with fetal macrosomia and clinical characteristics in mothers and newborns. ( 29137266 )
2017
8
Potential prognostic biomarkers of cardiovascular disease in fetal macrosomia: the impact of gestational diabetes. ( 28298172 )
2017
9
Measurement and evaluation of fetal fat layer in the prediction of fetal macrosomia in pregnancies complicated by gestational diabetes. ( 28631075 )
2017
10
Frequency of fetal macrosomia and the associated risk factors in pregnancies without gestational diabetes mellitus. ( 28451039 )
2017
11
Third trimester ultrasound for fetal macrosomia: optimal timing and institutional specific accuracy. ( 29183184 )
2017
12
Associated outcomes to fetal macrosomia: effect of maternal diabetes. ( 29424871 )
2017
13
Morbidity Associated with Fetal Macrosomia among Women with Diabetes Mellitus. ( 29183096 )
2017
14
AN ERUPTION PATTERN OF DECIDUOUS TEETH IN CHILDREN BORN WITH FETAL MACROSOMIA DURING THE FIRST YEAR OF LIFE. ( 28452722 )
2017
15
Induction of labour at or near term for suspected fetal macrosomia. ( 27208913 )
2016
16
Practice Bulletin No. 173 Summary: Fetal Macrosomia. ( 27776066 )
2016
17
Vacuum extraction in fetal macrosomia and risk of neonatal complications: a population-based cohort study. ( 27472147 )
2016
18
Peptidome profiling of umbilical cord plasma associated with gestational diabetes-induced fetal macrosomia. ( 26945739 )
2016
19
Amniotic fluid index and estimated fetal weight for prediction of fetal macrosomia: a prospective observational study. ( 27596358 )
2016
20
Induction of labour for fetal macrosomia: do we finally have an answer? ( 27921388 )
2016
21
Fetal macrosomia as a risk factor for shoulder dystocia during vacuum extraction. ( 27549142 )
2016
22
Gestational diabetes: Glycaemic predictors for fetal macrosomia and maternal risk of future diabetes. ( 26818892 )
2016
23
Risk factors and outcomes of fetal macrosomia in a tertiary centre in Tanzania: a case-control study. ( 27557930 )
2016
24
Induction of labour for suspected fetal macrosomia, Boulvain et al (2016). ( 27652444 )
2016
25
Comparison of 2- and 3-Dimensional Sonography for Estimation of Birth Weight and Neonatal Adiposity in the Setting of Suspected Fetal Macrosomia. ( 27091915 )
2016
26
Practice Bulletin No. 173: Fetal Macrosomia. ( 27776071 )
2016
27
Fetal macrosomia: induction of labour or expectant management? ( 26595633 )
2015
28
Effect of Personalized Nutrition Guidance on the Birth Rate of Fetal Macrosomia in Chinese Population: A Meta-analysis of Nine Randomized Controlled Trials. ( 27352186 )
2015
29
Determinants and outcome of fetal macrosomia in a Nigerian tertiary hospital. ( 26903699 )
2015
30
Does fetal macrosomia affect umbilical artery Doppler velocity waveforms in pregnancies complicated by gestational diabetes? ( 26699801 )
2015
31
Low cord blood serum levels of vitamin D: cause or effect of fetal macrosomia? ( 26411220 )
2015
32
The Effects of Prepregnancy Body Mass Index and Gestational Weight Gain on Fetal Macrosomia Among American Indian/Alaska Native Women. ( 26122253 )
2015
33
Fetal macrosomia: induction of labour or expectant management? ( 26595636 )
2015
34
An Evidence-Based Approach to Defining Fetal Macrosomia. ( 26499356 )
2015
35
Fetal macrosomia: induction of labour or expectant management? ( 26595635 )
2015
36
Weight gain in pregnancy, maternal age and gestational age in relation to fetal macrosomia. ( 25954731 )
2015
37
Cord blood copeptin concentrations in fetal macrosomia. ( 26477270 )
2015
38
Fetal macrosomia: induction of labour or expectant management? - Authors' reply. ( 26595634 )
2015
39
Fetal Macrosomia at a Tertiary Care Centre in Lagos, Nigeria. ( 27295826 )
2015
40
Physical activity, sedentary behaviour and fetal macrosomia in uncomplicated pregnancies: A prospective cohort study. ( 24861673 )
2014
41
Maternal obesity and occurrence of fetal macrosomia: a systematic review and meta-analysis. ( 25544943 )
2014
42
Counseling for Fetal Macrosomia: An Estimated Fetal Weight of 4,000a88g is Excessively Low. ( 24839149 )
2014
43
Differential expression of circulating miRNAs in maternal plasma in pregnancies with fetal macrosomia. ( 25370776 )
2014
44
Fetal macrosomia: a problem in need of a policy. ( 24395685 )
2014
45
Third trimester insulin levels are not correlated with fetal macrosomia or delivery complications. ( 24937972 )
2014
46
Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. ( 25231897 )
2014
47
Increased mRNA levels of apolipoprotein M and apolipoprotein AI in the placental tissues with fetal macrosomia. ( 25194312 )
2014
48
Estimate of fetal weight by ultrasound within two weeks of delivery in the detection of fetal macrosomia. ( 24773582 )
2014
49
Amniotic fluid insulin and C-peptide as predictive markers for fetal macrosomia, birth injuries, and delivery complications? ( 24423633 )
2014
50
Sonographic weight estimation in fetal macrosomia: influence of the time interval between estimation and delivery. ( 25534163 )
2014

Variations for Fetal Macrosomia

Expression for Fetal Macrosomia

Search GEO for disease gene expression data for Fetal Macrosomia.

Pathways for Fetal Macrosomia

Pathways related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 IGF1 IGF2 INS INSR
2
Show member pathways
12.43 APOA1 APOB APOM SLC2A3
3
Show member pathways
12.12 IGF1 INS INSR LEP
4
Show member pathways
12 APOA1 APOB INS INSR
5
Show member pathways
11.9 IGF1 INS INSR
6
Show member pathways
11.83 IGF1 INS INSR
7 11.79 IGF1 INS LEP
8
Show member pathways
11.73 APOA1 APOB LCAT
9 11.66 IGF1 IGFBP3 INS
10 11.61 IGF1 INS INSR
11 11.22 IGF1 IGF2 INS
12 11.13 INS INSR LEP
13 11.02 IGF1 INS INSR
14 10.94 APOA1 APOB
15 10.88 INSR LEP
16 10.7 IGF1 INS INSR
17 10.12 IGF1 IGF2 IGFBP3

GO Terms for Fetal Macrosomia

Cellular components related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.8 APOA1 APOB IGFBP3 INS
2 extracellular space GO:0005615 9.65 APOA1 APOB APOM IGF1 IGF2 IGFBP3
3 endosome lumen GO:0031904 9.54 APOB INS
4 endocytic vesicle lumen GO:0071682 9.52 APOA1 APOB
5 chylomicron GO:0042627 9.51 APOA1 APOB
6 high-density lipoprotein particle GO:0034364 9.5 APOA1 APOM LCAT
7 spherical high-density lipoprotein particle GO:0034366 9.48 APOA1 APOM
8 intermediate-density lipoprotein particle GO:0034363 9.46 APOA1 APOB
9 insulin-like growth factor ternary complex GO:0042567 9.43 IGF1 IGFBP3
10 very-low-density lipoprotein particle GO:0034361 9.43 APOA1 APOB APOM
11 discoidal high-density lipoprotein particle GO:0034365 9.4 APOA1 APOM
12 insulin-like growth factor binding protein complex GO:0016942 9.37 IGF1 IGFBP3
13 extracellular region GO:0005576 9.36 APOA1 APOB APOM IGF1 IGF2 IGFBP3
14 low-density lipoprotein particle GO:0034362 9.33 APOA1 APOB APOM

Biological processes related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.88 IGF2 INS INSR LEP
2 carbohydrate metabolic process GO:0005975 9.88 IGF2 INS INSR PGM1 SLC2A3
3 lipid transport GO:0006869 9.86 APOA1 APOB APOM
4 platelet degranulation GO:0002576 9.86 APOA1 IGF1 IGF2
5 steroid metabolic process GO:0008202 9.85 APOA1 APOB LCAT
6 glucose homeostasis GO:0042593 9.85 INS INSR LEP
7 response to estradiol GO:0032355 9.85 APOB LEP OXT
8 insulin receptor signaling pathway GO:0008286 9.83 IGF2 INS INSR
9 cholesterol homeostasis GO:0042632 9.83 APOA1 APOB APOM LCAT
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.81 IGF1 INS LEP
11 cholesterol metabolic process GO:0008203 9.8 APOA1 APOB LCAT LEP
12 retinoid metabolic process GO:0001523 9.79 APOA1 APOB APOM
13 activation of protein kinase B activity GO:0032148 9.75 IGF1 INS INSR
14 positive regulation of glucose import GO:0046326 9.74 IGF1 INS INSR
15 cholesterol transport GO:0030301 9.73 APOA1 APOB LCAT
16 cellular protein metabolic process GO:0044267 9.73 APOA1 APOB IGF1 IGF2 IGFBP3 INS
17 cholesterol efflux GO:0033344 9.72 APOA1 APOB APOM
18 lipoprotein metabolic process GO:0042157 9.71 APOA1 APOB APOM
19 eating behavior GO:0042755 9.69 LEP OXT
20 adrenal gland development GO:0030325 9.69 APOA1 INSR
21 positive regulation of glycolytic process GO:0045821 9.69 IGF1 INS INSR
22 positive regulation of lipid biosynthetic process GO:0046889 9.68 APOA1 INS
23 high-density lipoprotein particle assembly GO:0034380 9.67 APOA1 APOM
24 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.67 IGF1 IGFBP3
25 glucose metabolic process GO:0006006 9.67 IGF2 INS LEP PGM1
26 chylomicron assembly GO:0034378 9.66 APOA1 APOB
27 high-density lipoprotein particle clearance GO:0034384 9.66 APOA1 APOM
28 neuron projection maintenance GO:1990535 9.65 INS INSR
29 very-low-density lipoprotein particle remodeling GO:0034372 9.65 APOA1 LCAT
30 chylomicron remodeling GO:0034371 9.64 APOA1 APOB
31 exocrine pancreas development GO:0031017 9.63 IGF2 INSR
32 reverse cholesterol transport GO:0043691 9.63 APOA1 APOM LCAT
33 positive regulation of respiratory burst GO:0060267 9.62 INS INSR
34 bone mineralization involved in bone maturation GO:0035630 9.61 IGF1 LEP
35 high-density lipoprotein particle remodeling GO:0034375 9.61 APOA1 APOM LCAT
36 positive regulation of developmental growth GO:0048639 9.6 INSR LEP
37 regulation of intestinal cholesterol absorption GO:0030300 9.59 APOA1 LEP
38 positive regulation of insulin receptor signaling pathway GO:0046628 9.58 IGF2 INS LEP
39 lipoprotein biosynthetic process GO:0042158 9.5 APOA1 APOB LCAT
40 positive regulation of mitotic nuclear division GO:0045840 9.46 IGF1 IGF2 INS INSR
41 positive regulation of glycogen biosynthetic process GO:0045725 9.26 IGF1 IGF2 INS INSR
42 positive regulation of MAPK cascade GO:0043410 9.1 IGF1 IGF2 IGFBP3 INS INSR LEP
43 positive regulation of cell proliferation GO:0008284 10.04 IGF1 IGF2 INS INSR LEP
44 regulation of signaling receptor activity GO:0010469 10.01 IGF1 IGF2 INS LEP OXT

Molecular functions related to Fetal Macrosomia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.58 APOA1 APOB APOM
2 cholesterol transporter activity GO:0017127 9.43 APOA1 APOB
3 lipid transporter activity GO:0005319 9.43 APOA1 APOB APOM
4 insulin-like growth factor I binding GO:0031994 9.37 IGFBP3 INSR
5 hormone activity GO:0005179 9.35 IGF1 IGF2 INS LEP OXT
6 insulin receptor binding GO:0005158 9.33 IGF1 IGF2 INS
7 insulin-like growth factor II binding GO:0031995 9.32 IGFBP3 INSR
8 insulin-like growth factor receptor binding GO:0005159 8.92 IGF1 IGF2 INS INSR

Sources for Fetal Macrosomia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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