MCID: FTL021
MIFTS: 42

Fetal Macrosomia

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Fetal Macrosomia

MalaCards integrated aliases for Fetal Macrosomia:

Name: Fetal Macrosomia 52 54 71

Classifications:



External Ids:

UMLS 71 C0015938

Summaries for Fetal Macrosomia

MalaCards based summary : Fetal Macrosomia is related to hyperinsulinemic hypoglycemia and gestational diabetes. An important gene associated with Fetal Macrosomia is INS (Insulin), and among its related pathways/superpathways are AMP-activated Protein Kinase (AMPK) Signaling and Folate Metabolism. The drugs Meperidine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and breast, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 74 Large for gestational age (LGA) is an indication of high prenatal growth... more...

Related Diseases for Fetal Macrosomia

Diseases related to Fetal Macrosomia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia 30.6 INSR INS IGF2
2 gestational diabetes 30.6 LEP INSR INS IGF2 IGF1
3 hypertriglyceridemia, familial 30.4 INS APOB APOA1
4 hypoglycemia 30.3 INSR INS IGFBP3 IGF2 IGF1
5 beckwith-wiedemann syndrome 30.0 INS IGF2 IGF1 H19
6 placenta disease 29.9 OXT INS IGF2
7 asphyxia neonatorum 29.9 OXT INS
8 protein-energy malnutrition 29.7 LEPQTL1 LEP IGF1
9 insulin-like growth factor i 29.3 LEP INSR INS IGFBP3 IGF2 IGF1
10 hyperglycemia 29.2 SLC2A3 LEP INSR INS IGF1 APOB
11 hyperinsulinism 28.8 LEPQTL1 LEP INSR INS IGFBP3 IGF2
12 diabetes mellitus 28.7 LEP LCAT INSR INS IGFBP3 IGF2
13 glucose intolerance 28.6 LEPQTL1 LEP INSR INS IGFBP3 IGF1
14 diabetes mellitus, type i 28.6 LEP INSR INS IGFBP3 IGF2 IGF1
15 pre-eclampsia 28.4 OXT LEP INS IGFBP3 IGF2 IGF1
16 body mass index quantitative trait locus 11 25.5 SLC2A3 OXT LEPQTL1 LEP LCAT INSR
17 perlman syndrome 11.6
18 kagami-ogata syndrome 11.3
19 overgrowth syndrome 10.4
20 silver-russell syndrome due to 11p15 microduplication 10.4 IGF2 H19
21 silver-russell syndrome due to an imprinting defect of 11p15 10.4 IGF2 H19
22 beckwith-wiedemann syndrome due to imprinting defect of 11p15 10.4 IGF2 H19
23 hypoglycemic coma 10.4 INS IGF2
24 pax6-related aniridia 10.4 IGF2 H19
25 generalized atherosclerosis 10.4 INS APOB
26 hyperlipoproteinemia, type iv 10.4 APOB APOA1
27 hemihyperplasia, isolated 10.4 IGF2 H19
28 type 1 diabetes mellitus 2 10.4 INS IGF2
29 pituitary infarct 10.4 INS IGF1
30 acidophil adenoma 10.4 INS IGF1
31 apo a-i deficiency 10.3 LCAT APOA1
32 silent myocardial infarction 10.3 INS APOB APOA1
33 erb's palsy 10.3
34 hyperlipoproteinemia, type v 10.3 INS APOB APOA1
35 familial lcat deficiency 10.3 LCAT APOA1
36 slipped capital femoral epiphysis 10.3 IGFBP3 IGF1
37 intermediate coronary syndrome 10.3 INS APOB APOA1
38 defective apolipoprotein b-100 10.3 LCAT APOB
39 body mass index quantitative trait locus 1 10.3
40 amyloidosis aa 10.3 LCAT APOA1
41 hypoalphalipoproteinemia 10.3 LCAT APOA1
42 mammographic density 10.3 IGFBP3 IGF1
43 potter's syndrome 10.3 INS IGF2 IGF1
44 familial lipoprotein lipase deficiency 10.3 APOB APOA1
45 wilms tumor predisposition 10.2 IGF2 H19
46 homozygous familial hypercholesterolemia 10.2 APOB APOA1
47 sheehan syndrome 10.2 INS IGF1
48 lipoprotein glomerulopathy 10.2 LCAT APOB
49 diabetic encephalopathy 10.2 INS IGF1
50 fish-eye disease 10.2 LCAT APOA1

Graphical network of the top 20 diseases related to Fetal Macrosomia:



Diseases related to Fetal Macrosomia

Symptoms & Phenotypes for Fetal Macrosomia

MGI Mouse Phenotypes related to Fetal Macrosomia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 APOA1 APOB APOM ARHGEF11 IGF1 IGF2
2 cardiovascular system MP:0005385 10.17 APOA1 APOB ARHGEF11 IGF1 IGF2 IGFBP3
3 endocrine/exocrine gland MP:0005379 10.06 APOA1 IGF1 IGF2 IGFBP3 INS INSR
4 adipose tissue MP:0005375 10 ARHGEF11 IGF1 IGFBP3 INS INSR LEP
5 liver/biliary system MP:0005370 9.92 APOA1 APOB IGF2 IGFBP3 INS INSR
6 nervous system MP:0003631 9.85 APOB ARHGEF11 IGF1 IGF2 IGFBP3 INS
7 muscle MP:0005369 9.8 APOB IGF1 IGF2 IGFBP3 INS INSR
8 renal/urinary system MP:0005367 9.5 IGF1 IGF2 INS INSR LCAT LEP
9 reproductive system MP:0005389 9.23 APOB IGF1 IGF2 INS INSR LEP

Drugs & Therapeutics for Fetal Macrosomia

Drugs for Fetal Macrosomia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Meperidine Approved Phase 4 57-42-1 4058
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
5
Racepinephrine Approved Phase 4 329-65-7 838
6
Metformin Approved Phase 4 657-24-9 14219 4091
7 Narcotics Phase 4
8 Pharmaceutical Solutions Phase 4
9 Analgesics, Opioid Phase 4
10 Analgesics Phase 4
11 Anesthetics Phase 4
12 Epinephryl borate Phase 4
13 Insulin, Globin Zinc Phase 4
14 Hypoglycemic Agents Phase 4
15 insulin Phase 4
16
Diazoxide Approved Phase 2, Phase 3 364-98-7 3019
17
Ergonovine Approved Phase 3 60-79-7 443884
18
Lactitol Approved, Investigational Phase 3 585-88-6, 585-86-4 493591
19
Oxytocin Approved, Vet_approved Phase 3 50-56-6 53477758 439302
20
Carbetocin Approved, Investigational Phase 3 37025-55-1 71715 16681432
21 Vasodilator Agents Phase 2, Phase 3
22 Antihypertensive Agents Phase 2, Phase 3
23
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
24
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
25 Gastrointestinal Agents Phase 1
26 Antineoplastic Agents, Hormonal Phase 1
27 Antiemetics Phase 1
28 glucocorticoids Phase 1
29 Anti-Inflammatory Agents Phase 1
30
tannic acid Approved 1401-55-4
31
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
32
Zinc Approved, Investigational 7440-66-6 32051
33
Insulin aspart Approved 116094-23-6 16132418
34
leucovorin Approved 58-05-9 6006 143
35
Iron Approved, Experimental 15438-31-0, 7439-89-6 27284 23925
36
Misoprostol Approved 59122-46-2 5282381
37
Tranexamic Acid Approved 1197-18-8 5526
38
Exenatide Approved, Investigational 141758-74-9 15991534
39 Kava Approved, Investigational, Nutraceutical 9000-38-8
40
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
41 Mitogens
42 Sunflower
43 Omega 3 Fatty Acid
44 Insulin, Isophane
45 Isophane Insulin, Human
46 Isophane insulin, beef
47 Trace Elements
48 Vitamins
49 Vitamin B Complex
50 Hematinics

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Induction of Labor or Waiting for Suspicion Fetal Macrosomia (DAME) Completed NCT00190320 Phase 4
2 Is There Any Effect of Meperidine on the Length of Duration of Labor? A Prospective Randomized Controlled Trial. Completed NCT01555671 Phase 4 Placebo;Meperidine
3 Outcomes of Epidural Versus Combined Spinal and Epidural (CSE) Anesthetic Technique on the Success of Trial of Labor After Cesarean (TOLAC): A Pilot Study Completed NCT02105558 Phase 4 Epidural anesthesia;Combined spinal and epidural anesthesia
4 Metformin Use to Improve Pregnancy Outcome in Women With Type 1 Diabetes. A Randomized Double-blind Placebo-controlled Multicenter Study. Recruiting NCT03765359 Phase 4 metforminhydrochloride;Placebo Oral Tablet
5 Use for Diazoxide in the Initial Management of Hypoglycemia in Infants of Diabetic Mothers and Infants Large for Gestation Unknown status NCT00994149 Phase 2, Phase 3 Diazoxide;Ora-plus
6 Carbetocin Versus Oxytocin in the Management of Atonic Post Partum Haemorrhage (PPH) in Women Delivered Vaginally: A Randomised Controlled Trial Unknown status NCT02410759 Phase 3 Carbetocin;Ergometrine
7 Ergometrine Versus Oxytocin in the Management of Atonic Post-partum Haemorrhage (PPH) in Women Delivered Vaginally: A Randomised Controlled Trial Unknown status NCT02306733 Phase 3 Ergometrine;Oxytocin
8 Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Undergoing Caesarean Sections for Placenta Previa: A Randomised Controlled Trial Unknown status NCT02303418 Phase 3 Carbetocin;Oxytocin
9 Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Delivered Vaginally With at Least 2 Risk Factors for Atonic PPH: A Randomised Controlled Trial Completed NCT02304042 Phase 3 Carbetocin;Oxytocin
10 Carbetocin Versus Oxytocin in the Management of Atonic Post Partum Haemorrhage (PPH) in Women Delivered Vaginally: A Randomised Controlled Trial Completed NCT02304055 Phase 3 Carbetocin;Oxytocin
11 A Prospective Randomized Trial of Home Versus Hospital Care in Glucose Monitoring of Gestational Diabetes and Mild Gestational Hyperglycemia Completed NCT01441518 Phase 2
12 Dexamethasone Effect on Induction Delivery Interval at Term Randomized Controlled Trial Completed NCT03658590 Phase 1 Dexamethasone;Distilled Water
13 Effect of Fish Oil Supplementation in Women With Gestational Diabetes on Insulin Like Growth Factor-1 DNA Methylation in Newborns Unknown status NCT02371343
14 Fetal Head Circumference as a Predictor of Operative Delivery Unknown status NCT02739503
15 Induction of Labor Versus Expectant Management of Large for Gestational Age/Macrosomic Babies at Term. A Multi-center Randomized Trial Unknown status NCT02315820
16 A Customized Low Glycaemic-index (GI) Diet, Introduced at First Trimester of Pregnancy by Both Gynecologist and Dietitian, Prevents Large for Gestational Age (LGA) Newborns in Overweight/Obese Pregnant Women Unknown status NCT02750774
17 Effect of Fetal Front-abdominal Wall Thickness on Birth Weight and Perinatal Outcome at 24-26. Gestational Weeks Completed NCT03232294
18 Randomized Controlled, Multicenter Study Evaluating Treatment of Glucose Intolerance in Pregnancy Completed NCT00625781 Insulin aspart and Insulin human (isophane)
19 The Role of Umbilical Cord Thickness, Interventricular Septum Thickness and HbA1C Levels in Prediction of Fetal Macrosomia in Patients With Gestational Diabetes Mellitus Completed NCT02643225
20 Regulation Of Maternal Fuel Supply And Neonatal Adiposity Completed NCT00826904
21 Epigenetic Alteration of Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) in Cord Blood Samples in Macrosomia Exposed to Intrauterine Hyperglycaemia Completed NCT03165643
22 Fructosamines and Gestational Diabetes (FRUCTO) Completed NCT02159378
23 Placental miRNA (microRNA) Profile in Fetal Overgrowth Related to Maternal Obesity Study Completed NCT01935076
24 Challenging the Gold Standard: A Pilot Study Comparing CGMS and Capillary Glucose Monitors Versus 3 Hour GTT to Diagnose Gestational Diabetes Mellitus Completed NCT01074489
25 Exercise Training in Pregnancy. Good for the Mother - Good for the Child? Completed NCT01243554
26 Incentives Targeting Gestational Weight Gain in Overweight/Obese Low Income Women Completed NCT02233673
27 Correlation Between Placental Thickness in the Second and Third Trimester and Fetal Weight Completed NCT02473991
28 Prophylactic Dextrose Gel for Newborns at High-risk for Hypoglycemia Completed NCT02523222
29 Effect of Tahneek With Dates on Hypoglycemia in Newborn Infants: A Randomised Control Trial Completed NCT03726697
30 Automated Fetal Weight Estimation: A Multicenter Validation Using Fractional Limb Volume Completed NCT03002246
31 Obesity as a Risk Factor for Small for Gestational Age and Intrauterine Growth Restriction Infants Completed NCT00371657
32 New Ultrasonographic Parameters for Fetal Weight Prediction Completed NCT03962153
33 Role of Macronutrient Diet Composition on Maternal and Infant Metabolic Outcomes in Gestational Diabetes Completed NCT01719029
34 Exploration of the Lipid Metabolism During the Diabetic Pregnancies and Research for New Biological Predictors to Nutritional Interventions Completed NCT00639964
35 Cycle Study:an Exercise Intervention to Prevent Gestational Diabetes in Overweight and Obese Chinese Pregnant Women Completed NCT02304718
36 Impact of Iron/Folic Acid Versus Folic Acid Supplements During Pregnancy on Maternal and Children's Health: A Randomized Controlled Trial in China Completed NCT02221752
37 Longitudinal Studies of Breast Milk Zinc Transfer to Appropriate- and Small-for-gestational-age, Predominantly Breast Fed, Bangladeshi Infants Completed NCT01728766
38 Longitudinal Measures of Leptin in Pregnant Women Who Developed Preeclampsia Completed NCT01649167
39 The Prediction of Fetal Macrosomia by Measurement of Placenta Volume and Thickness in Pregnant Women With Diabetes Mellitus Recruiting NCT03451838
40 Study on the Relationship of Gut Microbiota and Changes of SCFAs With Glucolipid Metabolism in Pregnant Women With Abnormal Fetal Size and Their Newborns Recruiting NCT04399434
41 The Effect of Carbetocin Versus Oral Tranexamic Acid Plus, Buccal Misoprostol on Blood Loss After Vaginal Delivery: a Randomized Controlled Trial Recruiting NCT03708497 carbetocin;Tranexamic acid plus misoprostol;misoprostol
42 Fetal Interventricular Septum Thickness and Maternal Gestational Diabetes Control Recruiting NCT03654521
43 Visualizing Beta Cells in Patients With a History of Gestational Diabetes Recruiting NCT03182296
44 Lifestyle Intervention in Preparation for Pregnancy (LIPP) Recruiting NCT03146156
45 Estimation of Fetal Weight by MR Imaging to PREdict Neonatal MACROsomia (PREMACRO Study) Active, not recruiting NCT02713568
46 The MODE Trial: A Pilot Trial Investigating Planned Caesarean Section Versus Induction of Labour for Women With Class III Obesity Not yet recruiting NCT03985618
47 Flash Glucose Monitoring in Gestational Diabetes Mellitus: Study Protocol for a Randomized Controlled Trial Not yet recruiting NCT04422821
48 Healthy for my Baby- A Randomized Controlled Trial Assessing a Preconception Clinically Integrated Technological Intervention to Improve the Lifestyle of Overweight Women and Their Partners Not yet recruiting NCT04242069
49 Resting Metabolic Rate, Insulin Resistance, and Attitude Towards Weight Gain During Pregnancy to Predict Maternal Weight Gain and Neonatal Body Composition. Terminated NCT00634764
50 CONTRADYS : A Randomized Controlled Trial of a New Prophylactic Maneuver, the "Pushing" Maneuver, Aiming to Reduce the Risk for Shoulder Dystocia Terminated NCT01297439

Search NIH Clinical Center for Fetal Macrosomia

Genetic Tests for Fetal Macrosomia

Anatomical Context for Fetal Macrosomia

MalaCards organs/tissues related to Fetal Macrosomia:

40
Placenta, Testes, Breast, Ovary, Liver, Thyroid, Bone

Publications for Fetal Macrosomia

Articles related to Fetal Macrosomia:

(show top 50) (show all 882)
# Title Authors PMID Year
1
Factors predicting the need for insulin therapy in patients with gestational diabetes mellitus. 61 54
20071050 2010
2
Polycystic ovarian syndrome--prognosis and treatment outcomes. 61 54
18007129 2007
3
No loss of genomic imprinting of IGF-II and H19 in placentas of diabetic pregnancies with fetal macrosomia. 61 54
17306581 2007
4
Relation between insulin kinetics and insulin sensitivity in pregnancy. 54 61
12864780 2003
5
Screening for gestational diabetes: a summary of the evidence for the U.S. Preventive Services Task Force. 61 54
12576264 2003
6
Gestational diabetes: a review of the treatment options. 54 61
15981952 2003
7
Prevalence of maternal obesity in an urban center. 54 61
12439501 2002
8
Uterine rupture and dehiscence: ten-year review and case-control study. 61 54
11958242 2002
9
Fetal shoulder dystocia. 61 54
12596626 2002
10
Effect of insulin and insulin-like growth factor I on fetal macrosomia in healthy women. 54 61
11811284 2001
11
Macrosomia associated with maternal serum insulin-like growth factor-I and -II in diabetic pregnancy. 54 61
11339926 2001
12
Cord leptin level and fetal macrosomia. 61 54
11042305 2000
13
Macrosomia revisited: ponderal index and leptin delineate subtypes of fetal overgrowth. 54 61
10486473 1999
14
Prior third- or fourth-degree perineal tears and recurrence risks. 61 54
10190670 1999
15
Anti-insulin antibodies and birth weight in pregnancies complicated by diabetes. 61 54
10195707 1998
16
In vitro modulation of L-arginine transport in trophoblast cells by glucose. 61 54
9893012 1998
17
Insulin-like growth factors, their binding proteins, and fetal macrosomia in offspring of nondiabetic pregnant women. 54 61
9475683 1998
18
On the association between maternal phosphoglucomutase 1 (PGM1) and fetal macrosomia in diabetic pregnancy. 61 54
8863716 1996
19
Growth promoting peptides in diabetic and non-diabetic pregnancy: interactions with trophoblastic receptors and serum carrier proteins. 54 61
8887130 1996
20
Use of fetal ultrasound to select metabolic therapy for pregnancies complicated by mild gestational diabetes. 54 61
8026282 1994
21
Lack of association between maternal phosphoglucomutase-1 phenotype and fetal macrosomia in diabetic pregnancy. 54 61
8193100 1994
22
Genetic and non genetic factors in the outcome of diabetic pregnancy. 54 61
7791012 1994
23
Maternal insulin to lower the risk of fetal macrosomia in diabetic pregnancy. 54 61
1868636 1991
24
Prevention of neonatal macrosomia in gestational diabetes by the use of intensive dietary therapy and home glucose monitoring. 54 61
2006939 1991
25
Transplacental passage of insulin in pregnant women with insulin-dependent diabetes mellitus. Its role in fetal macrosomia. 61 54
2195347 1990
26
Risk factors associated with neonatal brachial plexus palsy in the United States. 61
31856038 2020
27
Fetal macrosomia in a Hispanic/Latinx predominant cohort and altered expressions of genes related to placental lipid transport and metabolism. 61
32494035 2020
28
Phenotypes of fetal macrosomia and risk of stillbirth among term deliveries over the previous four decades. 61
31925852 2020
29
Technology-supported lifestyle interventions to improve maternal-fetal outcomes in women with gestational diabetes mellitus: A meta-analysis. 61
32193015 2020
30
Effect of paternal body mass index on neonatal outcomes of singletons after frozen-thawed embryo transfer cycles: analysis of 7,908 singleton newborns. 61
32402450 2020
31
Pre-pregnancy maternal obesity, macrosomia, and risk of stillbirth: A population-based study. 61
32562938 2020
32
Identification of newborns with birthweight ≥ 4,500g: Ultrasound within one- vs. two weeks of delivery. 61
32353616 2020
33
Maternal-fetal repercussions of Phyllanthus niruri L. treatment during rat pregnancy. 61
32145330 2020
34
Identification of large-for-gestational age fetuses using antenatal customized fetal growth charts: Can we improve the prediction of abnormal labor course? 61
32199297 2020
35
Induction of labour indications and timing: A systematic analysis of clinical guidelines. 61
31285166 2020
36
Kagami-Ogata syndrome: an important differential diagnosis to Beckwith-Wiedemann syndrome. 61
31994200 2020
37
Infant Death Following Home Birth: A Case Report of Fatal Neonatal Hypoglycemia. 61
31800970 2020
38
Are there specific factors associated with prenatally undiagnosed foetal macrosomia? 61
32438136 2020
39
Placental Lactogen as a Marker of Maternal Obesity, Diabetes, and Fetal Growth Abnormalities: Current Knowledge and Clinical Perspectives. 61
32316284 2020
40
Ferulic acid confers protection on islet β cells and placental tissues of rats with gestational diabetes mellitus. 61
32359381 2020
41
Risk Factors and Birth Outcomes Associated with Teenage Pregnancy: A Canadian Sample. 61
31634579 2020
42
The test accuracy of antenatal ultrasound definitions of fetal macrosomia to predict birth injury: A systematic review. 61
31978846 2020
43
Fetal front-abdominal wall thickness in the second trimester as a predictor of abnormal fetal growth. 61
32208785 2020
44
Trends in the incidence of fetal macrosomia and its phenotypes in the United States, 1971-2017. 61
31811414 2020
45
Ensemble Learning to Improve the Prediction of Fetal Macrosomia and Large-for-Gestational Age. 61
32023935 2020
46
The Accuracy of 22 Fetal Weight Estimation Formulas in Diabetic Pregnancies. 61
31195392 2020
47
Pregnancy outcomes associated with an abnormal 50-g glucose screen during pregnancy: a systematic review and Meta-analysis. 61
31893960 2020
48
Longitudinal cohort study of uterine artery Doppler in singleton pregnancies obtained by IVF/ICSI with fresh or frozen blastocyst transfers in relation to pregnancy outcomes. 61
31909549 2020
49
Effect of pregravid obesity on perinatal outcomes in singleton pregnancies following in vitro fertilization and the weight-loss goals to reduce the risks of poor pregnancy outcomes: A retrospective cohort study. 61
32053669 2020
50
Is Embryo Cryopreservation Causing Macrosomia-and What Else? 61
32047479 2020

Variations for Fetal Macrosomia

Expression for Fetal Macrosomia

Search GEO for disease gene expression data for Fetal Macrosomia.

Pathways for Fetal Macrosomia

Pathways related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.19 LEP INSR INS IGF1
2
Show member pathways
12.04 INSR INS APOB APOA1
3
Show member pathways
11.86 INSR INS IGF1
4 11.82 LEP INS IGF1
5
Show member pathways
11.76 LCAT APOB APOA1
6 11.71 INSR INS IGF1
7 11.68 INS IGFBP3 IGF1
8 11.45 INSR IGF2 IGF1 ARHGEF11
9 11.27 INS IGF2 IGF1
10 11.23 LEP INS IGFBP3 IGF1
11 11.21 INSR INS IGF1
12 11.13 LEP INSR INS
13 10.9 INSR INS IGF1
14 10.84 LEP INS
15 10.12 IGFBP3 IGF2 IGF1

GO Terms for Fetal Macrosomia

Cellular components related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 OXT LEP LCAT INS IGFBP3 IGF2
2 endoplasmic reticulum lumen GO:0005788 9.8 INS IGFBP3 APOB APOA1
3 extracellular region GO:0005576 9.7 PGM1 OXT LEP LCAT INS IGFBP3
4 endosome lumen GO:0031904 9.54 INS APOB
5 endocytic vesicle lumen GO:0071682 9.52 APOB APOA1
6 chylomicron GO:0042627 9.51 APOB APOA1
7 very-low-density lipoprotein particle GO:0034361 9.5 APOM APOB APOA1
8 spherical high-density lipoprotein particle GO:0034366 9.48 APOM APOA1
9 intermediate-density lipoprotein particle GO:0034363 9.46 APOB APOA1
10 insulin-like growth factor ternary complex GO:0042567 9.43 IGFBP3 IGF1
11 low-density lipoprotein particle GO:0034362 9.43 APOM APOB APOA1
12 discoidal high-density lipoprotein particle GO:0034365 9.4 APOM APOA1
13 insulin-like growth factor binding protein complex GO:0016942 9.37 IGFBP3 IGF1
14 high-density lipoprotein particle GO:0034364 8.92 LCAT APOM APOB APOA1

Biological processes related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.04 LEP INSR INS IGF2 IGF1
2 positive regulation of protein kinase B signaling GO:0051897 9.89 LEP INSR INS IGF2
3 steroid metabolic process GO:0008202 9.86 LCAT APOB APOA1
4 platelet degranulation GO:0002576 9.86 IGF2 IGF1 APOA1
5 glucose homeostasis GO:0042593 9.85 LEP INSR INS
6 response to estradiol GO:0032355 9.85 OXT LEP APOB
7 carbohydrate metabolic process GO:0005975 9.85 SLC2A3 PGM1 INSR INS IGF2
8 insulin receptor signaling pathway GO:0008286 9.83 INSR INS IGF2
9 cholesterol homeostasis GO:0042632 9.83 LCAT APOM APOB APOA1
10 cholesterol metabolic process GO:0008203 9.81 LEP LCAT APOB APOA1
11 retinoid metabolic process GO:0001523 9.79 APOM APOB APOA1
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.78 LEP INSR INS IGF1
13 positive regulation of glucose import GO:0046326 9.76 INSR INS IGF1
14 activation of protein kinase B activity GO:0032148 9.75 INSR INS IGF1
15 positive regulation of glycolytic process GO:0045821 9.74 INSR INS IGF1
16 lipoprotein metabolic process GO:0042157 9.73 APOM APOB APOA1
17 cellular protein metabolic process GO:0044267 9.73 INS IGFBP3 IGF2 IGF1 APOB APOA1
18 positive regulation of insulin receptor signaling pathway GO:0046628 9.72 LEP INS IGF2
19 cholesterol transport GO:0030301 9.71 LCAT APOB APOA1
20 positive regulation of lipid biosynthetic process GO:0046889 9.68 INS APOA1
21 phosphatidylcholine metabolic process GO:0046470 9.67 LCAT APOA1
22 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.67 IGFBP3 IGF1
23 cholesterol efflux GO:0033344 9.67 APOM APOB APOA1
24 glucose metabolic process GO:0006006 9.67 PGM1 LEP INS IGF2
25 high-density lipoprotein particle assembly GO:0034380 9.66 APOM APOA1
26 high-density lipoprotein particle clearance GO:0034384 9.65 APOM APOA1
27 neuron projection maintenance GO:1990535 9.65 INSR INS
28 chylomicron assembly GO:0034378 9.65 APOB APOA1
29 very-low-density lipoprotein particle remodeling GO:0034372 9.64 LCAT APOA1
30 chylomicron remodeling GO:0034371 9.63 APOB APOA1
31 exocrine pancreas development GO:0031017 9.63 INSR IGF2
32 positive regulation of respiratory burst GO:0060267 9.62 INSR INS
33 bone mineralization involved in bone maturation GO:0035630 9.61 LEP IGF1
34 positive regulation of developmental growth GO:0048639 9.61 LEP INSR
35 reverse cholesterol transport GO:0043691 9.61 LCAT APOM APOA1
36 regulation of intestinal cholesterol absorption GO:0030300 9.6 LEP APOA1
37 high-density lipoprotein particle remodeling GO:0034375 9.58 LCAT APOM APOA1
38 lipoprotein biosynthetic process GO:0042158 9.5 LCAT APOB APOA1
39 positive regulation of mitotic nuclear division GO:0045840 9.46 INSR INS IGF2 IGF1
40 positive regulation of glycogen biosynthetic process GO:0045725 9.26 INSR INS IGF2 IGF1
41 positive regulation of MAPK cascade GO:0043410 9.1 LEP INSR INS IGFBP3 IGF2 IGF1

Molecular functions related to Fetal Macrosomia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.58 APOM APOB APOA1
2 intermembrane cholesterol transfer activity GO:0120020 9.43 APOB APOA1
3 lipid transporter activity GO:0005319 9.43 APOM APOB APOA1
4 insulin-like growth factor I binding GO:0031994 9.37 INSR IGFBP3
5 hormone activity GO:0005179 9.35 OXT LEP INS IGF2 IGF1
6 insulin receptor binding GO:0005158 9.33 INS IGF2 IGF1
7 insulin-like growth factor II binding GO:0031995 9.32 INSR IGFBP3
8 insulin-like growth factor receptor binding GO:0005159 8.92 INSR INS IGF2 IGF1

Sources for Fetal Macrosomia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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