MCID: FTL064
MIFTS: 25

Fetal Methylmercury Syndrome

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Fetal Methylmercury Syndrome

MalaCards integrated aliases for Fetal Methylmercury Syndrome:

Name: Fetal Methylmercury Syndrome 54 60
Minamata Disease 54 60
Methyl Mercury Antenatal Infection 60
Methyl Mercury Antenatal Exposure 54

Characteristics:

Orphanet epidemiological data:

60
fetal methylmercury syndrome
Inheritance: Not applicable; Age of onset: Antenatal,Neonatal;

Classifications:



External Ids:

ICD10 via Orphanet 35 T56.1
UMLS via Orphanet 75 C0086626 C0265376
Orphanet 60 ORPHA1917

Summaries for Fetal Methylmercury Syndrome

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 1917Disease definitionFoetal methylmercury syndrome is characterised by a group of symptoms that may be observed in a foetus or newborn when the mother was exposed during pregnancy to excessive amounts of methylmercury.EpidemiologyAccidents have led to the birth of about 800 affected children worldwide over the last 50 years.Clinical descriptionIn the late-1950s, methylmercury toxicity became highly publicised after an outbreak of cerebral palsy and microcephaly in newborns from the fishing village of Minimata Bay, Japan. These abnormalities were caused by methylmercury contamination of fish in the bay, and were termed Minimata Disease. Similar intoxications also occurred in Iraq after seeds contaminated with methylmercury were mistakenly used to make bread. In this population, infants exposed in utero displayed psychomotor retardation and cerebral palsy. Similar neurological impairment has been reported in other instances of food contamination, such as in infants of American Indian women who ingested pork contaminated with phenylmercuric acetate.EtiologyThere are two main types of mercury, metallic mercury (a heavy liquid element at room temperature, used in thermometers) and organic mercury (like methylmercury, used as antifungal agent in seed dressings). The selective neurotoxicity of organic mercury does not appear to apply to metallic mercury and its salts. Methylmercury is lipophilic and more readily distributed to the brain tissue than mercuric salts. Metallic mercury does not cross the placenta readily, and it has been estimated that the rate of methylmercury transport into the brain may exceed that of mercury by a factor of 10.Diagnostic methodsExposure to methylmercury can be monitored by measuring the concentration in the hair. All fish contain some methylmercury, and frequent consumption of highly contaminated fish can lead to a hair concentration of methylmercury ranging between 10 and 50 ppm. A level of 50 ppm in hair has been established as the lowest toxic level, and the World Health Organization (WHO) has applied a safety factor of 10 to cover risks in the most sensitive populations. Thus, 5 ppm has been generally adopted as the international standard for the upper tolerable level of mercury in hair.Management and treatmentSince maternal exposure to methylmercury is primarily through fish consumption, it is recommended that women of childbearing age should not consume more than 350g of fish per week. In addition, they should not be occupationally exposed to air concentrations of mercury vapor greater than 0.01 mg. per cubic meter, to inorganic and phenylmercuric compounds at concentrations greater than 0.02 mg per cubic meter, or to any detectable concentration of methylmercury.Visit the Orphanet disease page for more resources.

MalaCards based summary : Fetal Methylmercury Syndrome, also known as minamata disease, is related to mercury poisoning and tremor. Affiliated tissues include brain, placenta and heart, and related phenotypes are muscular hypotonia and hearing impairment

Related Diseases for Fetal Methylmercury Syndrome

Diseases related to Fetal Methylmercury Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 mercury poisoning 11.5
2 tremor 10.3
3 spasticity 10.2
4 aging 10.0
5 cerebral palsy 10.0
6 neuropathy 10.0

Graphical network of the top 20 diseases related to Fetal Methylmercury Syndrome:



Diseases related to Fetal Methylmercury Syndrome

Symptoms & Phenotypes for Fetal Methylmercury Syndrome

Human phenotypes related to Fetal Methylmercury Syndrome:

60 33
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 muscular hypotonia 60 33 hallmark (90%) Very frequent (99-80%) HP:0001252
2 hearing impairment 60 33 hallmark (90%) Very frequent (99-80%) HP:0000365
3 microcephaly 60 33 hallmark (90%) Very frequent (99-80%) HP:0000252
4 visual impairment 60 33 hallmark (90%) Very frequent (99-80%) HP:0000505
5 short stature 60 33 hallmark (90%) Very frequent (99-80%) HP:0004322

Drugs & Therapeutics for Fetal Methylmercury Syndrome

Search Clinical Trials , NIH Clinical Center for Fetal Methylmercury Syndrome

Genetic Tests for Fetal Methylmercury Syndrome

Anatomical Context for Fetal Methylmercury Syndrome

MalaCards organs/tissues related to Fetal Methylmercury Syndrome:

42
Brain, Placenta, Heart, Testes, Cortex

Publications for Fetal Methylmercury Syndrome

Articles related to Fetal Methylmercury Syndrome:

(show top 50) (show all 88)
# Title Authors Year
1
Potential therapeutic effect of repetitive transcranial magnetic stimulation for tremor in Minamata disease: A case report. ( 29627030 )
2018
2
Accelerated functional losses in ageing congenital Minamata disease patients. ( 30102975 )
2018
3
Three Case Reports of Successful Vibration Therapy of the Plantar Fascia for Spasticity Due to Cerebral Palsy-Like Syndrome, Fetal-Type Minamata Disease. ( 27082608 )
2016
4
Characteristics of hand tremor and postural sway in patients with fetal-type Minamata disease. ( 27853104 )
2016
5
Secondary sex ratio in regions severely exposed to methylmercury "Minamata disease". ( 26497019 )
2016
6
Intrauterine Exposure to Methylmercury and Neurocognitive Functions: Minamata Disease. ( 24971622 )
2015
7
Lower urinary tract symptoms in patients with Niigata Minamata disease: a case-control study 50 years after methyl mercury pollution. ( 23163739 )
2013
8
Critical appraisal of the 1977 diagnostic criteria for Minamata disease. ( 23298421 )
2013
9
Rescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+ spike frequency. ( 22411806 )
2012
10
Vibration therapy of the plantar fascia improves spasticity of the lower limbs of a patient with fetal-type Minamata disease in the chronic stage. ( 22675016 )
2011
11
Congenital minamata disease: intrauterine methylmercury poisoning. Teratology 18:285-8. 1978. ( 20973053 )
2010
12
The pathology of methylmercury poisoning (Minamata disease): The 50th Anniversary of Japanese Society of Neuropathology. ( 20500453 )
2010
13
Minamata disease: catastrophic poisoning due to a failed public health response. ( 19367301 )
2009
14
What has methylmercury in umbilical cords told us? - Minamata disease. ( 19878970 )
2009
15
Index of congenital Minamata disease in Canadian areas of concern in the Great Lakes: an eco-social epidemiological approach. ( 19953398 )
2009
16
Minamata disease revisited: an update on the acute and chronic manifestations of methyl mercury poisoning. ( 17681548 )
2007
17
The severity of Minamata disease declined in 25 years: temporal profile of the neurological findings analyzed by multiple logistic regression model. ( 15635274 )
2005
18
Logistic model analysis of neurological findings in Minamata disease and the predicting index. ( 11838584 )
2002
19
An autopsy case of minamata disease (methylmercury poisoning)--pathological viewpoints of peripheral nerves. ( 12512873 )
2002
20
Autonomic nervous functions in fetal type Minamata disease patients: assessment of heart rate variability. ( 12630553 )
2002
21
Cerebellar blood flow in methylmercury poisoning (Minamata disease). ( 11338409 )
2001
22
Clinical investigation of the lesions responsible for sensory disturbance in Minamata disease. ( 11874251 )
2001
23
Congenital Minamata disease: warnings from Japan's experience. ( 10921517 )
2000
24
Minamata disease. ( 11037181 )
2000
25
Methylmercury level in umbilical cords from patients with congenital Minamata disease. ( 10507148 )
1999
26
MR findings of Minamata disease--organic mercury poisoning. ( 9562057 )
1998
27
Widespread neuronal degeneration in rats following oral administration of methylmercury during the postnatal developing phase: a model of fetal-type minamata disease. ( 9518689 )
1998
28
Methylmercury dose estimation from umbilical cord concentrations in patients with Minamata disease. ( 9600802 )
1998
29
Representation of the visual field in the striate cortex: comparison of MR findings with visual field deficits in organic mercury poisoning (Minamata disease). ( 9194440 )
1997
30
Pathology of Minamata disease. ( 9437807 )
1997
31
Cancer mortality in Minamata disease patients exposed to methylmercury through fish diet. ( 8952217 )
1996
32
Neurologic features of chronic minamata disease (organic mercury poisoning) and incidence of complications with aging. ( 8522732 )
1995
33
Neurologic features of chronic Minamata disease (organic mercury poisoning) certified at autopsy. ( 8563113 )
1995
34
Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. ( 7734058 )
1995
35
Minamata disease redress settled. ( 8551833 )
1995
36
MR findings in seven patients with organic mercury poisoning (Minamata disease). ( 7985580 )
1994
37
MR imaging of minamata disease: qualitative and quantitative analysis. ( 7863032 )
1994
38
Mercury in the Umbilical Cord: Implications for Risk Assessment for Minamata Disease. ( 9679113 )
1994
39
Profile of subjective complaints and activities of daily living among current patients with Minamata disease after 3 decades. ( 8243418 )
1993
40
Epidemiological and clinical features of Minamata disease. ( 8404770 )
1993
41
A fetal type of Minamata disease. An autopsy case report with special reference to the nervous system. ( 1520402 )
1992
42
The discovery of the causal agent of Minamata disease. ( 1536159 )
1992
43
Truncal hypesthesia in patients with Minamata disease. ( 1600268 )
1992
44
Minamata disease: A 1989 update on the mercury poisoning epidemic in Japan. ( 24202728 )
1991
45
Present mercury levels in red blood cells of nearby inhabitants about 30 years after the outbreak of Minamata disease. ( 1914996 )
1991
46
Minamata disease: a story of mercury's malevolence. ( 1948221 )
1991
47
Minamata disease: what is a keystone of its molecular mechanism? A biochemical theory on the nature of methyl mercury neurotoxicity. ( 2269614 )
1990
48
Mercury level and histochemical distribution in a human brain with Minamata disease following a long-term clinical course of twenty-six years. ( 2562539 )
1989
49
Neurotological follow-up studies upon Minamata disease. ( 2635534 )
1989
50
Minamata disease demonstrated by computed tomography. ( 3357567 )
1988

Variations for Fetal Methylmercury Syndrome

Expression for Fetal Methylmercury Syndrome

Search GEO for disease gene expression data for Fetal Methylmercury Syndrome.

Pathways for Fetal Methylmercury Syndrome

GO Terms for Fetal Methylmercury Syndrome

Sources for Fetal Methylmercury Syndrome

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