MCID: FBR008
MIFTS: 49

Fibrillary Astrocytoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Fibrillary Astrocytoma

MalaCards integrated aliases for Fibrillary Astrocytoma:

Name: Fibrillary Astrocytoma 12 53 59 55 15 73
Diffuse Astrocytoma 12 53 59 73
Gemistocytic Astrocytoma 53 73
Protoplasmic Astrocytoma 53 73
Low-Grade Diffuse Astrocytoma 53
Fibrillary Astrocytic Tumors 12

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6726
MeSH 44 D001254
NCIt 50 C4322
SNOMED-CT 68 71314006
UMLS via Orphanet 74 C0280785 C0334582
ICD10 via Orphanet 34 C71.9

Summaries for Fibrillary Astrocytoma

Disease Ontology : 12 An astrocytoma that is characterized as a low grade astrocytoma and has material basis in neoplastic astrocytes.

MalaCards based summary : Fibrillary Astrocytoma, also known as diffuse astrocytoma, is related to gemistocytic astrocytoma and protoplasmic astrocytoma, and has symptoms including seizures, headache and motor manifestations. An important gene associated with Fibrillary Astrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and DNA damage_ATM/ATR regulation of G1/S checkpoint. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and liver.

Wikipedia : 76 Fibrillary astrocytomas also called low-grade or diffuse astrocytomas, are a group of primary... more...

Related Diseases for Fibrillary Astrocytoma

Diseases related to Fibrillary Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 gemistocytic astrocytoma 34.1 GFAP IDH2
2 protoplasmic astrocytoma 33.9 GFAP IDH2 TP53
3 giant cell glioblastoma 30.0 GFAP IDH1 MGMT TP53
4 gliosarcoma 29.7 GFAP IDH1 MGMT TP53
5 glioblastoma 29.7 H3F3A IDH1 IDH2 MGMT TP53
6 pilocytic astrocytoma 29.7 GFAP IDH1 KIAA1549
7 pleomorphic xanthoastrocytoma 29.7 GFAP IDH1 MGMT TP53
8 glioma 29.5 H3F3A IDH1 IDH2 TP53
9 glioblastoma multiforme 29.4 GFAP IDH1 MGMT TP53
10 grade iii astrocytoma 29.2 GFAP IDH2 MGMT PCNA TP53
11 glioma susceptibility 1 29.2 GFAP H3F3A IDH1 IDH2 TP53
12 oligodendroglioma 29.1 GFAP IDH1 IDH2 MGMT PCNA TP53
13 astrocytoma 10.5
14 interval angle-closure glaucoma 10.3 IDH1 IDH2
15 adult oligodendroglioma 10.2 IDH1 IDH2
16 enchondroma 10.2 IDH1 IDH2
17 cytogenetically normal acute myeloid leukemia 10.2 IDH1 IDH2
18 chondroblastic osteosarcoma 10.2 IDH1 IDH2
19 multiple enchondromatosis, maffucci type 10.2 IDH1 IDH2
20 intraductal papilloma 10.2 IDH1 IDH2
21 spindle cell hemangioma 10.2 IDH1 IDH2
22 periosteal chondrosarcoma 10.2 IDH1 IDH2
23 diffuse infiltrative lymphocytosis syndrome 10.2 IDH1 IDH2
24 drug-induced mental disorder 10.2 IDH1 IDH2
25 drug psychosis 10.2 IDH1 IDH2
26 undifferentiated pleomorphic sarcoma 10.2 IDH1 IDH2
27 periosteal osteogenic sarcoma 10.2 IDH1 TP53
28 2-hydroxyglutaric aciduria 10.2 IDH1 IDH2
29 testicular torsion 10.2 PCNA TP53
30 mature teratoma 10.2 PCNA TP53
31 oral leukoplakia 10.2 PCNA TP53
32 extraventricular neurocytoma 10.2 GFAP IDH1
33 suppressor of tumorigenicity 3 10.2 PCNA TP53
34 frontal convexity meningioma 10.2 GFAP TP53
35 d-2-hydroxyglutaric aciduria 1 10.2 IDH1 IDH2
36 gastric lymphoma 10.2 PCNA TP53
37 gliofibroma 10.2 GFAP TP53
38 cerebral convexity meningioma 10.2 GFAP TP53
39 dysembryoplastic neuroepithelial tumor 10.1 GFAP IDH1
40 cellular ependymoma 10.1 GFAP TP53
41 meninges sarcoma 10.1 GFAP TP53
42 central nervous system primitive neuroectodermal neoplasm 10.1 GFAP TP53
43 intracranial chondrosarcoma 10.1 IDH1 IDH2 TP53
44 cerebral neuroblastoma 10.1 GFAP TP53
45 enchondromatosis, multiple, ollier type 10.1 IDH1 IDH2
46 spinal cancer 10.1 GFAP TP53
47 angiocentric glioma 10.1 GFAP IDH1
48 bile duct adenocarcinoma 10.1 IDH1 IDH2 TP53
49 ependymoblastoma 10.1 GFAP TP53
50 cerebral ventricle cancer 10.1 GFAP TP53

Graphical network of the top 20 diseases related to Fibrillary Astrocytoma:



Diseases related to Fibrillary Astrocytoma

Symptoms & Phenotypes for Fibrillary Astrocytoma

UMLS symptoms related to Fibrillary Astrocytoma:


seizures, headache, motor manifestations, sensory manifestations

Drugs & Therapeutics for Fibrillary Astrocytoma

Drugs for Fibrillary Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Dermatologic Agents Phase 3,Phase 1
4 Serotonin Agents Phase 3
5 Anti-Allergic Agents Phase 3
6 Serotonin Antagonists Phase 3
7 Histamine H1 Antagonists Phase 3
8
Histamine Phosphate Phase 3 51-74-1 65513
9 Antipruritics Phase 3
10 Neurotransmitter Agents Phase 3,Not Applicable
11 Histamine Antagonists Phase 3
12 Gastrointestinal Agents Phase 3,Not Applicable
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Dacarbazine Approved, Investigational Phase 1, Phase 2 4342-03-4 5351166
15
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
16
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
17
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
18
Veliparib Investigational Phase 1, Phase 2 912444-00-9 11960529
19 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
20 Alkylating Agents Phase 1, Phase 2
21 Antineoplastic Agents, Alkylating Phase 1, Phase 2
22 Angiogenesis Inhibitors Phase 1, Phase 2
23 Angiogenesis Modulating Agents Phase 1, Phase 2
24
Verteporfin Approved, Investigational Phase 1 129497-78-5
25
Trioxsalen Approved Phase 1 3902-71-4 5585
26 Photosensitizing Agents Phase 1
27 Dihematoporphyrin Ether Phase 1
28
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
29 Dopamine Agents Not Applicable
30 Dihydroxyphenylalanine Not Applicable
31 Fluorides Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas Completed NCT01514201 Phase 1, Phase 2 Temozolomide;Veliparib
3 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Recruiting NCT01884740 Phase 1, Phase 2 SIACI of Erbitux and Bevacizumab
4 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
5 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
6 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 Not Applicable 18F-fluoro-dihydroxyphenylalanine
7 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Fibrillary Astrocytoma

Genetic Tests for Fibrillary Astrocytoma

Anatomical Context for Fibrillary Astrocytoma

MalaCards organs/tissues related to Fibrillary Astrocytoma:

41
Brain, T Cells, Liver, Bone, Spinal Cord, Cerebellum, Thyroid

Publications for Fibrillary Astrocytoma

Articles related to Fibrillary Astrocytoma:

(show all 26)
# Title Authors Year
1
Tumor cell vanishing with radiological changes suggesting progression in IDH-mutated diffuse astrocytoma treated only with surgery. ( 30079885 )
2018
2
Identification of time-to-peak on dynamic 18F-FET-PET as a prognostic marker specifically in IDH1/2 mutant diffuse astrocytoma. ( 29016996 )
2018
3
A rare case of a molecular "adult-type" diffuse astrocytoma arising in a child. ( 29198071 )
2018
4
Chemotherapy of Diffuse Astrocytoma (WHO grade II) in Adults. ( 29393182 )
2018
5
Diffuse Astrocytoma, IDH-Wildtype: A Dissolving Diagnosis. ( 29444314 )
2018
6
Seizure-Induced Increased 18F-DOPA Uptake in a Child With Diffuse Astrocytoma and Transient Brain MRI Abnormalities Related to Status Epilepticus. ( 29465492 )
2018
7
cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant. ( 29497819 )
2018
8
"The simplest explanation is usually the correct one" - Can Occam's razor be applied for diffuse astrocytoma and paradoxical amino acid metabolism? ( 28470341 )
2017
9
TREATMENT OF PROGRESSION OF DIFFUSE ASTROCYTOMA BY HERBAL MEDICINE: CASE REPORT. ( 28480352 )
2016
10
Adult Diffuse Astrocytoma in the Medulla Oblongata: Molecular Biological Analyses Including H3F3A Mutation of Histone H3.3. ( 28663993 )
2016
11
Radial expansion rates and tumor growth kinetics predict malignant transformation in contrast-enhancing low-grade diffuse astrocytoma. ( 26095141 )
2015
12
IDH1 mutation is prognostic for diffuse astrocytoma but not low-grade oligodendrogliomas in patients not treated with early radiotherapy. ( 26243269 )
2015
13
Supratentorial low-grade diffuse astrocytoma: medical management. ( 25173138 )
2014
14
Gliosarcoma arising from a fibrillary astrocytoma. ( 21737284 )
2011
15
Dysgeusia: an atypical and neglected psychiatric symptom induced by fibrillary astrocytoma. ( 21497786 )
2011
16
Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum. ( 20860893 )
2010
17
Akt/protein kinase B overexpression as an accurate prognostic marker in adult diffuse astrocytoma. ( 19240976 )
2009
18
An unusual tuberous sclerosis case presenting with fibrillary astrocytoma. ( 12187056 )
2002
19
BCL2 and BAX mRNA concentration profile in fibrillary astrocytoma. ( 11820596 )
2001
20
A clinicopathologic reappraisal of brain stem tumor classification. Identification of pilocystic astrocytoma and fibrillary astrocytoma as distinct entities. ( 11013373 )
2000
21
Interobserver reproducibility among neuropathologists and surgical pathologists in fibrillary astrocytoma grading. ( 10785254 )
2000
22
Intrasellar presentation of a cystic optic chiasm fibrillary astrocytoma. ( 9309792 )
1996
23
Fibrillary astrocytoma in a goat: pathologic, immunohistochemical, and ultrastructural study. ( 8844587 )
1996
24
Glial fibrillary acidic protein (GFAP): purification from human fibrillary astrocytoma, development and validation of a radioimmunoassay for GFAP-like immunoactivity. ( 438840 )
1979
25
Fibrillary astrocytoma at the base of the skull in a 5 1/2-year-old girl. ( 904938 )
1977
26
Crystal formations in ultrastructure of fibrillary astrocytoma. ( 5973794 )
1966

Variations for Fibrillary Astrocytoma

Expression for Fibrillary Astrocytoma

Search GEO for disease gene expression data for Fibrillary Astrocytoma.

Pathways for Fibrillary Astrocytoma

Pathways related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.84 ATRX H3F3A MGMT
2 10.97 PCNA TP53
3 10.66 PCNA TP53
4 10.42 PCNA TP53
5
Show member pathways
9.74 IDH1 IDH2

GO Terms for Fibrillary Astrocytoma

Cellular components related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome, telomeric region GO:0000784 8.8 ATRX H3F3A PCNA

Biological processes related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.67 ATRX MGMT PCNA TP53
2 tricarboxylic acid cycle GO:0006099 9.51 IDH1 IDH2
3 cellular response to ionizing radiation GO:0071479 9.49 MGMT TP53
4 positive regulation of DNA repair GO:0045739 9.48 MGMT PCNA
5 replication fork processing GO:0031297 9.46 ATRX PCNA
6 DNA replication-independent nucleosome assembly GO:0006336 9.43 ATRX H3F3A
7 DNA methylation GO:0006306 9.4 ATRX MGMT
8 2-oxoglutarate metabolic process GO:0006103 9.32 IDH1 IDH2
9 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.26 ATRX TP53
10 NADP metabolic process GO:0006739 9.16 IDH1 IDH2
11 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
12 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.32 IDH1 IDH2
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 IDH1 IDH2
3 histone acetyltransferase binding GO:0035035 9.16 PCNA TP53
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Fibrillary Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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