MCID: FBR008
MIFTS: 44

Fibrillary Astrocytoma

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Fibrillary Astrocytoma

MalaCards integrated aliases for Fibrillary Astrocytoma:

Name: Fibrillary Astrocytoma 12 53 59 55 15 73
Diffuse Astrocytoma 12 53 59 73
Gemistocytic Astrocytoma 53 73
Protoplasmic Astrocytoma 53 73
Low-Grade Diffuse Astrocytoma 53
Fibrillary Astrocytic Tumors 12

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6726
MeSH 44 D001254
NCIt 50 C4322
SNOMED-CT 68 253063006 71314006
UMLS via Orphanet 74 C0280785 C0334582
ICD10 via Orphanet 34 C71.9

Summaries for Fibrillary Astrocytoma

Disease Ontology : 12 An astrocytoma that is characterized as a low grade astrocytoma and has material basis in neoplastic astrocytes.

MalaCards based summary : Fibrillary Astrocytoma, also known as diffuse astrocytoma, is related to gemistocytic astrocytoma and protoplasmic astrocytoma, and has symptoms including headache, seizures and motor manifestations. An important gene associated with Fibrillary Astrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are GADD45 Pathway and BARD1 signaling events. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include brain and cerebellum, and related phenotype is no phenotypic analysis.

Wikipedia : 76 Fibrillary astrocytomas also called low-grade or diffuse astrocytomas, are a group of primary... more...

Related Diseases for Fibrillary Astrocytoma

Diseases related to Fibrillary Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 gemistocytic astrocytoma 34.3 GFAP IDH2
2 protoplasmic astrocytoma 33.7 GFAP IDH2 TP53
3 gliosarcoma 29.1 GFAP IDH1 MGMT TP53
4 interval angle-closure glaucoma 10.8 IDH1 IDH2
5 adult oligodendroglioma 10.8 IDH1 IDH2
6 enchondroma 10.8 IDH1 IDH2
7 cytogenetically normal acute myeloid leukemia 10.8 IDH1 IDH2
8 intraductal papilloma 10.8 IDH1 IDH2
9 multiple enchondromatosis, maffucci type 10.8 IDH1 IDH2
10 spindle cell hemangioma 10.7 IDH1 IDH2
11 periosteal chondrosarcoma 10.7 IDH1 IDH2
12 undifferentiated pleomorphic sarcoma 10.7 IDH1 IDH2
13 periosteal osteogenic sarcoma 10.6 IDH1 TP53
14 drug-induced mental disorder 10.6 IDH1 IDH2
15 drug psychosis 10.6 IDH1 IDH2
16 diffuse infiltrative lymphocytosis syndrome 10.6 IDH1 IDH2
17 central nervous system organ benign neoplasm 10.6 KIAA1549 TP53
18 anal squamous cell carcinoma 10.6 MGMT TP53
19 2-hydroxyglutaric aciduria 10.5 IDH1 IDH2
20 bone giant cell sarcoma 10.5 H3F3A TP53
21 testicular torsion 10.5 PCNA TP53
22 malignant giant cell tumor 10.5 H3F3A TP53
23 mature teratoma 10.5 PCNA TP53
24 oral leukoplakia 10.5 PCNA TP53
25 intracranial chondrosarcoma 10.5 IDH1 IDH2 TP53
26 breast papillary carcinoma 10.5 IDH1 IDH2
27 brain stem cancer 10.4 H3F3A TP53
28 bile duct adenocarcinoma 10.4 IDH1 IDH2 TP53
29 suppressor of tumorigenicity 3 10.4 PCNA TP53
30 intrahepatic cholangiocarcinoma 10.4 IDH1 IDH2 TP53
31 pilocytic astrocytoma of cerebellum 10.4 IDH1 IDH2 KIAA1549
32 d-2-hydroxyglutaric aciduria 1 10.4 IDH1 IDH2
33 gastric lymphoma 10.4 PCNA TP53
34 extraventricular neurocytoma 10.4 GFAP IDH1
35 frontal convexity meningioma 10.4 GFAP TP53
36 cerebellar astrocytoma 10.4 IDH1 KIAA1549 TP53
37 gliofibroma 10.4 GFAP TP53
38 essential thrombocythemia 10.4 IDH1 IDH2 TP53
39 cerebral convexity meningioma 10.4 GFAP TP53
40 cellular ependymoma 10.4 GFAP TP53
41 dysembryoplastic neuroepithelial tumor 10.4 GFAP IDH1
42 astrocytoma 10.3
43 central nervous system primitive neuroectodermal neoplasm 10.3 GFAP TP53
44 cerebral neuroblastoma 10.3 GFAP TP53
45 spinal cancer 10.3 GFAP TP53
46 pilomyxoid astrocytoma 10.3 GFAP KIAA1549
47 enchondromatosis, multiple, ollier type 10.3 IDH1 IDH2
48 angiocentric glioma 10.3 GFAP IDH1
49 ependymoblastoma 10.3 GFAP TP53
50 inverted papilloma 10.3 PCNA TP53

Graphical network of the top 20 diseases related to Fibrillary Astrocytoma:



Diseases related to Fibrillary Astrocytoma

Symptoms & Phenotypes for Fibrillary Astrocytoma

UMLS symptoms related to Fibrillary Astrocytoma:


headache, seizures, motor manifestations, sensory manifestations

MGI Mouse Phenotypes related to Fibrillary Astrocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.02 ADD3 CAMK2G MGMT PCNA TP53

Drugs & Therapeutics for Fibrillary Astrocytoma

Drugs for Fibrillary Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
3 Dermatologic Agents Phase 3,Phase 1
4
Histamine Phosphate Phase 3 51-74-1 65513
5 Serotonin Agents Phase 3
6 Serotonin Antagonists Phase 3
7 Gastrointestinal Agents Phase 3,Not Applicable
8 Neurotransmitter Agents Phase 3,Not Applicable
9 Histamine Antagonists Phase 3
10 Histamine H1 Antagonists Phase 3
11 Anti-Allergic Agents Phase 3
12 Antipruritics Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Dacarbazine Approved, Investigational Phase 1, Phase 2 4342-03-4 5351166
15
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
16
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
17
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
18
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
19
Veliparib Investigational Phase 1, Phase 2 912444-00-9 11960529
20 Alkylating Agents Phase 1, Phase 2
21 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
22 Antineoplastic Agents, Alkylating Phase 1, Phase 2
23 Angiogenesis Inhibitors Phase 1, Phase 2
24 Angiogenesis Modulating Agents Phase 1, Phase 2
25 Protein Kinase Inhibitors Phase 1, Phase 2
26
Verteporfin Approved, Investigational Phase 1 129497-78-5
27
Trioxsalen Approved Phase 1 3902-71-4 5585
28 Dihematoporphyrin Ether Phase 1
29 Photosensitizing Agents Phase 1
30
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
31 Fluorides Not Applicable
32 Dihydroxyphenylalanine Not Applicable
33 Dopamine Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas Completed NCT01514201 Phase 1, Phase 2 Temozolomide;Veliparib
3 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Recruiting NCT01884740 Phase 1, Phase 2 SIACI of Erbitux and Bevacizumab
4 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
5 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
6 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
7 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 Not Applicable 18F-fluoro-dihydroxyphenylalanine
8 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Fibrillary Astrocytoma

Genetic Tests for Fibrillary Astrocytoma

Anatomical Context for Fibrillary Astrocytoma

MalaCards organs/tissues related to Fibrillary Astrocytoma:

41
Brain, Cerebellum

Publications for Fibrillary Astrocytoma

Articles related to Fibrillary Astrocytoma:

(show all 12)
# Title Authors Year
1
Gliosarcoma arising from a fibrillary astrocytoma. ( 21737284 )
2011
2
Dysgeusia: an atypical and neglected psychiatric symptom induced by fibrillary astrocytoma. ( 21497786 )
2011
3
Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum. ( 20860893 )
2010
4
An unusual tuberous sclerosis case presenting with fibrillary astrocytoma. ( 12187056 )
2002
5
BCL2 and BAX mRNA concentration profile in fibrillary astrocytoma. ( 11820596 )
2001
6
A clinicopathologic reappraisal of brain stem tumor classification. Identification of pilocystic astrocytoma and fibrillary astrocytoma as distinct entities. ( 11013373 )
2000
7
Interobserver reproducibility among neuropathologists and surgical pathologists in fibrillary astrocytoma grading. ( 10785254 )
2000
8
Intrasellar presentation of a cystic optic chiasm fibrillary astrocytoma. ( 9309792 )
1996
9
Fibrillary astrocytoma in a goat: pathologic, immunohistochemical, and ultrastructural study. ( 8844587 )
1996
10
Glial fibrillary acidic protein (GFAP): purification from human fibrillary astrocytoma, development and validation of a radioimmunoassay for GFAP-like immunoactivity. ( 438840 )
1979
11
Fibrillary astrocytoma at the base of the skull in a 5 1/2-year-old girl. ( 904938 )
1977
12
Crystal formations in ultrastructure of fibrillary astrocytoma. ( 5973794 )
1966

Variations for Fibrillary Astrocytoma

Expression for Fibrillary Astrocytoma

Search GEO for disease gene expression data for Fibrillary Astrocytoma.

Pathways for Fibrillary Astrocytoma

Pathways related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 PCNA TP53
2 10.42 PCNA TP53
3
Show member pathways
9.74 IDH1 IDH2

GO Terms for Fibrillary Astrocytoma

Cellular components related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.7 ADD3 ATRX CAMK2G H3F3A MGMT PCNA
2 replication fork GO:0005657 8.96 PCNA TP53
3 nuclear chromosome, telomeric region GO:0000784 8.8 ATRX H3F3A PCNA

Biological processes related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.67 ATRX MGMT PCNA TP53
2 cellular response to ionizing radiation GO:0071479 9.51 MGMT TP53
3 tricarboxylic acid cycle GO:0006099 9.49 IDH1 IDH2
4 replication fork processing GO:0031297 9.48 ATRX PCNA
5 positive regulation of DNA repair GO:0045739 9.46 MGMT PCNA
6 DNA replication-independent nucleosome assembly GO:0006336 9.43 ATRX H3F3A
7 DNA methylation GO:0006306 9.4 ATRX MGMT
8 2-oxoglutarate metabolic process GO:0006103 9.32 IDH1 IDH2
9 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.26 ATRX TP53
10 DNA ligation GO:0006266 9.16 MGMT PCNA
11 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
12 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.55 CAMK2G GFAP IDH1 PCNA TP53
2 NAD binding GO:0051287 9.37 IDH1 IDH2
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.32 IDH1 IDH2
4 histone acetyltransferase binding GO:0035035 9.26 PCNA TP53
5 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
6 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH1 IDH2

Sources for Fibrillary Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....