MCID: FBR023
MIFTS: 41

Fibrinogen Deficiency, Congenital

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Fibrinogen Deficiency, Congenital

MalaCards integrated aliases for Fibrinogen Deficiency, Congenital:

Name: Fibrinogen Deficiency, Congenital 20
Congenital Fibrinogen Deficiency 20 58 29

Characteristics:

Orphanet epidemiological data:

58
congenital fibrinogen deficiency
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare haematological diseases


Summaries for Fibrinogen Deficiency, Congenital

MalaCards based summary : Fibrinogen Deficiency, Congenital, also known as congenital fibrinogen deficiency, is related to afibrinogenemia, congenital and rare hemorrhagic disorder. An important gene associated with Fibrinogen Deficiency, Congenital is FGB (Fibrinogen Beta Chain), and among its related pathways/superpathways are Activated TLR4 signalling and Developmental Biology. Related phenotypes are fever and left ventricular hypertrophy

Related Diseases for Fibrinogen Deficiency, Congenital

Diseases related to Fibrinogen Deficiency, Congenital via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 afibrinogenemia, congenital 29.6 FGG FGB FGA
2 rare hemorrhagic disorder 10.1
3 autosomal recessive disease 9.9
4 portal vein thrombosis 9.9
5 chronic thromboembolic pulmonary hypertension 9.6 FGB FGA
6 cerebrovascular disease 9.4 FGB FGA
7 dysfibrinogenemia, congenital 9.4 FGG FGB FGA
8 thrombophilia 9.4 FGG FGB FGA
9 thrombosis 9.3 FGG FGB FGA
10 hemorrhagic disease 9.2 FGG FGB FGA

Graphical network of the top 20 diseases related to Fibrinogen Deficiency, Congenital:



Diseases related to Fibrinogen Deficiency, Congenital

Symptoms & Phenotypes for Fibrinogen Deficiency, Congenital

Human phenotypes related to Fibrinogen Deficiency, Congenital:

58 31 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
2 left ventricular hypertrophy 58 31 hallmark (90%) Very frequent (99-80%) HP:0001712
3 abdominal pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002027
4 micropenis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000054
5 microphthalmia 58 31 hallmark (90%) Very frequent (99-80%) HP:0000568
6 gingival bleeding 58 31 hallmark (90%) Very frequent (99-80%) HP:0000225
7 bruising susceptibility 58 31 hallmark (90%) Very frequent (99-80%) HP:0000978
8 internal hemorrhage 58 31 hallmark (90%) Very frequent (99-80%) HP:0011029
9 decreased testicular size 58 31 hallmark (90%) Very frequent (99-80%) HP:0008734
10 prolonged prothrombin time 58 31 hallmark (90%) Very frequent (99-80%) HP:0008151
11 volvulus 58 31 hallmark (90%) Very frequent (99-80%) HP:0002580
12 tachycardia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001649
13 cyanosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000961
14 loss of consciousness 58 31 hallmark (90%) Very frequent (99-80%) HP:0007185
15 developmental cataract 58 31 hallmark (90%) Very frequent (99-80%) HP:0000519
16 anaphylactic shock 58 31 hallmark (90%) Very frequent (99-80%) HP:0100845
17 opisthotonus 58 31 hallmark (90%) Very frequent (99-80%) HP:0002179
18 right ventricular hypertrophy 58 31 hallmark (90%) Very frequent (99-80%) HP:0001667
19 hemorrhagic ovarian cyst 58 31 hallmark (90%) Very frequent (99-80%) HP:0012886
20 abnormal umbilical stump bleeding 58 31 hallmark (90%) Very frequent (99-80%) HP:0011884
21 splenic rupture 58 31 hallmark (90%) Very frequent (99-80%) HP:0012223
22 clubbing of fingers 58 31 hallmark (90%) Very frequent (99-80%) HP:0100759
23 abnormality of the subungual region 58 31 hallmark (90%) Very frequent (99-80%) HP:0009723
24 subcutaneous hemorrhage 58 Very frequent (99-80%)
25 abnormal bleeding 58 Very frequent (99-80%)
26 abnormality of cardiovascular system morphology 58 Very frequent (99-80%)

Drugs & Therapeutics for Fibrinogen Deficiency, Congenital

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective, Open-label, Uncontrolled, Phase III Study to Assess the Efficacy, Safety and Pharmacokinetic of Octafibrin for On-demand Treatment of Acute Bleeding and to Prevent Bleeding During and After Surgery in Paediatric Subjects With Congenital Fibrinogen Deficiency Completed NCT02408484 Phase 3
2 Prospective, Open-label, Uncontrolled, Phase III Study to Assess the Efficacy and Safety of Octafibrin for On-demand Treatment of Acute Bleeding and to Prevent Bleeding During and After Surgery in Subjects With Congenital Fibrinogen Deficiency Completed NCT02267226 Phase 3 Octafibrin
3 Clinical Pharmacology, Efficacy and Safety Study of FGTW in Paediatric Patients With Severe Congenital Fibrinogen Deficiency Completed NCT02094430 Phase 2, Phase 3 biological: human fibrinogen concentrate
4 A Prospective, Open-label, Phase I/III Study Investigating Pharmacokinetic Properties of BT524 and Efficacy and Safety of BT524 in the Treatment and Prophylaxis of Bleeding in Patients With Congenital Fibrinogen Deficiency Recruiting NCT02065882 Phase 3
5 Efficacy and Safety of Fibrinogen Concentrate (Human) (FCH) for On-demand Treatment of Acute Bleeding in Subjects With Congenital Fibrinogen Deficiency Withdrawn NCT00916656 Phase 3
6 A Prospective, Controlled, Randomised, Crossover Study Investigating the Pharmacokinetic Properties, Surrogate Efficacy and Safety of Octafibrin Compared to Haemocomplettan® P/RiaSTAPTM in Patients With Congenital Fibrinogen Deficiency Completed NCT01575756 Phase 2
7 Pharmacokinetics of Haemocomplettan® P in Subjects With Congenital Fibrinogen Deficiency Completed NCT00496262 Phase 2
8 A Multicenter Study on the Retrospective Safety and Efficacy of Fibrinogen Concentrate (Human) (FCH) for Routine Prophylaxis, Treatment of Bleeding or Surgery in Subjects With Congenital Fibrinogen Deficiency With a Prospective Followup Component Completed NCT02427217
9 Post-marketing Observational Study on the Safety and Efficacy of Fibryga in Congenital Fibrinogen Deficiency Not yet recruiting NCT03793426

Search NIH Clinical Center for Fibrinogen Deficiency, Congenital

Genetic Tests for Fibrinogen Deficiency, Congenital

Genetic tests related to Fibrinogen Deficiency, Congenital:

# Genetic test Affiliating Genes
1 Congenital Fibrinogen Deficiency 29

Anatomical Context for Fibrinogen Deficiency, Congenital

Publications for Fibrinogen Deficiency, Congenital

Articles related to Fibrinogen Deficiency, Congenital:

(show all 40)
# Title Authors PMID Year
1
Pseudo-exon activation caused by a deep-intronic mutation in the fibrinogen gamma-chain gene as a novel mechanism for congenital afibrinogenaemia. 6
17854317 2007
2
Missense or splicing mutation? The case of a fibrinogen Bbeta-chain mutation causing severe hypofibrinogenemia. 6
15070683 2004
3
Congenital afibrinogenemia: first identification of splicing mutations in the fibrinogen Bbeta-chain gene causing activation of cryptic splice sites. 6
12393540 2002
4
Congenital afibrinogenaemia in a newborn infant due to a novel mutation in the fibrinogen aalpha gene. 6
12358944 2002
5
Analysis of Iranian patients allowed the identification of the first truncating mutation in the fibrinogen Bbeta-chain gene causing afibrinogenemia. 6
12161363 2002
6
Afibrinogenemia: first identification of a splicing mutation in the fibrinogen gamma chain gene leading to a major gamma chain truncation. 6
11001902 2000
7
A G-to-A mutation in IVS-3 of the human gamma fibrinogen gene causing afibrinogenemia due to abnormal RNA splicing. 6
11001903 2000
8
Mutations in the fibrinogen aalpha gene account for the majority of cases of congenital afibrinogenemia. 6
10891444 2000
9
Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion. 6
10666208 2000
10
The 11 kb FGA deletion responsible for congenital afibrinogenaemia is mediated by a short direct repeat in the fibrinogen gene cluster. 6
10602365 1999
11
Failure of DDAVP to shorten the prolonged bleeding time of two patients with congenital afibrinogenemia. 6
1471077 1992
12
Efficacy and safety of fibrinogen concentrate for on-demand treatment of bleeding and surgical prophylaxis in paediatric patients with congenital fibrinogen deficiency. 61
33326665 2020
13
Fibrinogen concentrate for bleeding in patients with congenital fibrinogen deficiency: Observational study of efficacy and safety for prophylaxis and treatment. 61
33313470 2020
14
Fibrinogen concentrate for treatment of bleeding and surgical prophylaxis in congenital fibrinogen deficiency patients. 61
31885190 2020
15
Congenital afibrinogenemia in a 4-year-old girl complicated with acute lymphoblastic leukemia. 61
32419423 2020
16
Two-Pronged Treatment of Hemoperitoneum and Abnormal Uterine Bleeding in an Adolescent Girl With Congenital Fibrinogen Deficiency. 61
32509792 2020
17
Clinical pharmacology, efficacy and safety study of a triple-secured fibrinogen concentrate in adults and adolescent patients with congenital fibrinogen deficiency. 61
30661302 2019
18
[Perioperative management of pregnant women combined with congenital fibrinogen deficiency: four cases report and literature review]. 61
30337762 2018
19
Biochemical characterization, stability, and pathogen safety of a new fibrinogen concentrate (fibryga®). 61
29336864 2018
20
Pharmacokinetics, clot strength and safety of a new fibrinogen concentrate: randomized comparison with active control in congenital fibrinogen deficiency. 61
29220876 2018
21
Efficacy and safety of a new human fibrinogen concentrate in patients with congenital fibrinogen deficiency: an interim analysis of a Phase III trial. 61
29194665 2018
22
Fibrinogen deficiency in a dog - a case report. 61
28629414 2017
23
Identification of novel mutations in congenital afibrinogenemia patients and molecular modeling of missense mutations in Pakistani population. 61
28912669 2017
24
[Congenital afibrinogenemia: about a case]. 61
28293349 2016
25
Molecular basis of quantitative fibrinogen disorders in 27 patients from India. 61
23560673 2013
26
Epidemiology and treatment of congenital fibrinogen deficiency. 61
23439004 2012
27
Acute myocardial infarction in a patient with hypofibrinogenemia: a case report. 61
22182477 2011
28
Fibrinogen replacement therapy for congenital fibrinogen deficiency. 61
21711446 2011
29
Pharmacokinetics and safety of fibrinogen concentrate. 61
19804533 2009
30
Results of an international, multicentre pharmacokinetic trial in congenital fibrinogen deficiency. 61
20109654 2009
31
Fibrinogen concentrate--a potential universal hemostatic agent. 61
19645632 2009
32
Treatment of congenital fibrinogen deficiency: overview and recent findings. 61
19851522 2009
33
Rotational thromboelastography for monitoring of fibrinogen concentrate therapy in fibrinogen deficiency. 61
19002044 2008
34
Efficacy and tolerability of a pasteurised human fibrinogen concentrate in patients with congenital fibrinogen deficiency. 61
15919240 2005
35
Liquid Extradural Hematoma With Congenital Fibrinogen Deficiency, Case Report. 61
2734693 1989
36
Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate. 61
2910912 1989
37
Liquid extradural hematoma with congenital fibrinogen deficiency. Case report. 61
3413669 1988
38
Cryoprecipitates in treatment of congenital fibrinogen deficiency. Case report. 61
5822778 1969
39
Congenital fibrinogen deficiency. 61
5704600 1968
40
[Function and behavior of thrombocytes in congenital fibrinogen deficiency]. 61
5714304 1968

Variations for Fibrinogen Deficiency, Congenital

ClinVar genetic disease variations for Fibrinogen Deficiency, Congenital:

6 (show top 50) (show all 157)
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 FGB NM_005141.4(FGB):c.1148T>G (p.Leu383Arg) SNV Pathogenic 16389 rs121909621 4:155490855-155490855 4:154569703-154569703
2 FGB NM_005141.4(FGB):c.1289G>A (p.Gly430Asp) SNV Pathogenic 16390 rs121909622 4:155491615-155491615 4:154570463-154570463
3 FGB NM_005141.4(FGB):c.958+13C>T SNV Pathogenic 16392 rs606231223 4:155490472-155490472 4:154569320-154569320
4 FGB NM_005141.4(FGB):c.1244+1G>T SNV Pathogenic 16393 rs606231224 4:155490952-155490952 4:154569800-154569800
5 FGB NM_005141.4(FGB):c.605T>A (p.Leu202Gln) SNV Pathogenic 16395 rs121909624 4:155488859-155488859 4:154567707-154567707
6 FGB NM_005141.4(FGB):c.139C>T (p.Arg47Ter) SNV Pathogenic 16396 rs121909625 4:155486984-155486984 4:154565832-154565832
7 FGA NC_000004.12:g.(154580323_154580329)_(154590210_154590216)del Deletion Pathogenic 16414 4:154580323-154590216
8 FGA NM_021871.4(FGA):c.510+1G>T SNV Pathogenic 16415 rs146387238 4:155508663-155508663 4:154587511-154587511
9 FGA NM_021871.4(FGA):c.502C>T (p.Arg168Ter) SNV Pathogenic 402230 rs755117226 4:155508672-155508672 4:154587520-154587520
10 FGB NM_005141.4(FGB):c.974G>C (p.Gly325Ala) SNV Pathogenic 800647 rs1578785111 4:155490681-155490681 4:154569529-154569529
11 FGB NM_005141.4(FGB):c.679T>C (p.Cys227Arg) SNV Pathogenic 800648 rs1578783532 4:155488933-155488933 4:154567781-154567781
12 FGA NM_021871.4(FGA):c.811C>T (p.Arg271Ter) SNV Pathogenic 800649 rs1578796476 4:155507770-155507770 4:154586618-154586618
13 FGA NM_021871.4(FGA):c.711dup (p.Lys238Ter) Duplication Pathogenic 16417 rs606231225 4:155507869-155507870 4:154586717-154586718
14 FGG NM_021870.3(FGG):c.78+5G>A SNV Pathogenic 16376 rs587776837 4:155533679-155533679 4:154612527-154612527
15 FGG NM_021870.3(FGG):c.307+5G>A SNV Pathogenic 16377 rs587776838 4:155533165-155533165 4:154612013-154612013
16 FGG NM_021870.3(FGG):c.667-320A>T SNV Pathogenic 16380 rs587776839 4:155530122-155530122 4:154608970-154608970
17 FGG NM_021870.3(FGG):c.666+23T>A SNV Pathogenic 800570 rs1578810856 4:155530759-155530759 4:154609607-154609607
18 FGG NM_021870.3(FGG):c.1022G>A (p.Trp341Ter) SNV Pathogenic 504885 rs1553965519 4:155527964-155527964 4:154606812-154606812
19 FGB NM_005141.5(FGB):c.490+1G>C SNV Likely pathogenic 981156 4:155487825-155487825 4:154566673-154566673
20 FGB NM_005141.5(FGB):c.794C>T (p.Pro265Leu) SNV Conflicting interpretations of pathogenicity 517313 rs6054 4:155489608-155489608 4:154568456-154568456
21 FGG NM_021870.3(FGG):c.323C>G (p.Ala108Gly) SNV Conflicting interpretations of pathogenicity 547969 rs148685782 4:155533035-155533035 4:154611883-154611883
22 FGG NM_021870.3(FGG):c.401G>A (p.Arg134Gln) SNV Uncertain significance 899461 4:155532957-155532957 4:154611805-154611805
23 FGG NM_021870.3(FGG):c.318C>T (p.Asp106=) SNV Uncertain significance 900592 4:155533040-155533040 4:154611888-154611888
24 FGG NM_021870.3(FGG):c.140C>T (p.Thr47Ile) SNV Uncertain significance 627235 rs138511699 4:155533337-155533337 4:154612185-154612185
25 FGG NM_021870.3(FGG):c.124G>A (p.Gly42Ser) SNV Uncertain significance 900593 4:155533353-155533353 4:154612201-154612201
26 FGG NM_021870.3(FGG):c.683T>C (p.Val228Ala) SNV Uncertain significance 899460 4:155529786-155529786 4:154608634-154608634
27 FGG NM_021870.3(FGG):c.620A>G (p.Tyr207Cys) SNV Uncertain significance 809696 rs775086103 4:155530828-155530828 4:154609676-154609676
28 FGG NM_021870.3(FGG):c.667-10G>C SNV Uncertain significance 347828 rs886059155 4:155529812-155529812 4:154608660-154608660
29 FGG NM_021870.3(FGG):c.*488C>T SNV Uncertain significance 347825 rs191297318 4:155525498-155525498 4:154604346-154604346
30 FGG NM_000509.5(FGG):c.-53A>G SNV Uncertain significance 347834 rs886059156 4:155533814-155533814 4:154612662-154612662
31 FGG NM_021870.3(FGG):c.*500C>T SNV Uncertain significance 902204 4:155525486-155525486 4:154604334-154604334
32 FGG NM_021870.3(FGG):c.*496A>C SNV Uncertain significance 902205 4:155525490-155525490 4:154604338-154604338
33 FGG NM_021870.3(FGG):c.*494A>G SNV Uncertain significance 902206 4:155525492-155525492 4:154604340-154604340
34 FGG NM_021870.3(FGG):c.1258A>G (p.Ile420Val) SNV Uncertain significance 903087 4:155526090-155526090 4:154604938-154604938
35 FGG NM_021870.3(FGG):c.1125C>T (p.Tyr375=) SNV Uncertain significance 903088 4:155527861-155527861 4:154606709-154606709
36 FGG NM_021870.3(FGG):c.1285G>T (p.Gly429Trp) SNV Uncertain significance 347826 rs145938787 4:155526063-155526063 4:154604911-154604911
37 FGG NM_021870.3(FGG):c.502A>G (p.Thr168Ala) SNV Uncertain significance 347829 rs141559764 4:155531249-155531249 4:154610097-154610097
38 FGG NM_000509.5(FGG):c.-130G>T SNV Uncertain significance 347835 rs749800940 4:155533891-155533891 4:154612739-154612739
39 FGA NM_021871.4(FGA):c.1918C>G (p.Pro640Ala) SNV Uncertain significance 902973 4:155506663-155506663 4:154585511-154585511
40 FGA NM_021871.4(FGA):c.1912G>A (p.Gly638Arg) SNV Uncertain significance 902974 4:155506669-155506669 4:154585517-154585517
41 FGB NM_005141.4(FGB):c.*1544T>C SNV Uncertain significance 347798 rs886059147 4:155493346-155493346 4:154572194-154572194
42 FGB NM_005141.4(FGB):c.298C>T (p.Pro100Ser) SNV Uncertain significance 696149 rs2227434 4:155487143-155487143 4:154565991-154565991
43 FGG NM_021870.3(FGG):c.19C>T (p.Pro7Ser) SNV Uncertain significance 347833 rs374845868 4:155533743-155533743 4:154612591-154612591
44 FGG NM_021870.3(FGG):c.1237A>G (p.Ile413Val) SNV Uncertain significance 347827 rs886059154 4:155526111-155526111 4:154604959-154604959
45 FGB NM_005141.4(FGB):c.564T>C (p.Asn188=) SNV Uncertain significance 347774 rs759250713 4:155488818-155488818 4:154567666-154567666
46 FGB NM_005141.4(FGB):c.*1671C>T SNV Uncertain significance 347801 rs765773409 4:155493473-155493473 4:154572321-154572321
47 FGB NM_005141.5(FGB):c.254T>C (p.Val85Ala) SNV Uncertain significance 901957 4:155487099-155487099 4:154565947-154565947
48 FGB NM_005141.5(FGB):c.*427G>A SNV Uncertain significance 902034 4:155492229-155492229 4:154571077-154571077
49 FGB NM_005141.5(FGB):c.*450T>A SNV Uncertain significance 902035 4:155492252-155492252 4:154571100-154571100
50 FGB NM_005141.5(FGB):c.*464C>T SNV Uncertain significance 902036 4:155492266-155492266 4:154571114-154571114

Expression for Fibrinogen Deficiency, Congenital

Search GEO for disease gene expression data for Fibrinogen Deficiency, Congenital.

Pathways for Fibrinogen Deficiency, Congenital

Pathways related to Fibrinogen Deficiency, Congenital according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 FGG FGB FGA
2
Show member pathways
12.94 FGG FGB FGA
3
Show member pathways
12.82 FGG FGB FGA
4
Show member pathways
12.78 FGG FGB FGA
5
Show member pathways
12.42 FGG FGB FGA
6
Show member pathways
12.41 FGG FGB FGA
7
Show member pathways
12.32 FGG FGB FGA
8
Show member pathways
11.94 FGG FGB FGA
9
Show member pathways
11.81 FGG FGB FGA
10
Show member pathways
11.77 FGG FGB FGA
11 11.71 FGG FGB FGA
12
Show member pathways
11.63 FGG FGB FGA
13 11.53 FGG FGB FGA
14
Show member pathways
11.32 FGG FGB FGA
15 10.84 FGG FGB FGA
16 10.49 FGG FGB FGA

GO Terms for Fibrinogen Deficiency, Congenital

Cellular components related to Fibrinogen Deficiency, Congenital according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.67 FGG FGB FGA
2 cell surface GO:0009986 9.58 FGG FGB FGA
3 external side of plasma membrane GO:0009897 9.54 FGG FGB FGA
4 collagen-containing extracellular matrix GO:0062023 9.5 FGG FGB FGA
5 endoplasmic reticulum lumen GO:0005788 9.48 FGG FGA
6 cell cortex GO:0005938 9.46 FGB FGA
7 extracellular vesicle GO:1903561 9.43 FGB FGA
8 blood microparticle GO:0072562 9.43 FGG FGB FGA
9 platelet alpha granule lumen GO:0031093 9.33 FGG FGB FGA
10 platelet alpha granule GO:0031091 9.13 FGG FGB FGA
11 fibrinogen complex GO:0005577 8.8 FGG FGB FGA

Biological processes related to Fibrinogen Deficiency, Congenital according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.79 FGG FGB FGA
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.79 FGG FGB FGA
3 blood coagulation GO:0007596 9.78 FGG FGB FGA
4 platelet degranulation GO:0002576 9.77 FGG FGB FGA
5 platelet activation GO:0030168 9.76 FGG FGB FGA
6 cell-matrix adhesion GO:0007160 9.75 FGG FGB FGA
7 response to calcium ion GO:0051592 9.74 FGG FGB FGA
8 hemostasis GO:0007599 9.73 FGG FGB FGA
9 positive regulation of protein secretion GO:0050714 9.72 FGG FGB FGA
10 toll-like receptor signaling pathway GO:0002224 9.71 FGG FGB FGA
11 platelet aggregation GO:0070527 9.7 FGG FGB FGA
12 positive regulation of substrate adhesion-dependent cell spreading GO:1900026 9.69 FGG FGB FGA
13 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.67 FGG FGB FGA
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.65 FGG FGB FGA
15 post-translational protein modification GO:0043687 9.63 FGG FGA
16 cellular protein metabolic process GO:0044267 9.63 FGG FGA
17 positive regulation of vasoconstriction GO:0045907 9.63 FGG FGB FGA
18 cellular response to interleukin-1 GO:0071347 9.62 FGG FGB
19 positive regulation of exocytosis GO:0045921 9.61 FGG FGB FGA
20 induction of bacterial agglutination GO:0043152 9.6 FGB FGA
21 cellular protein-containing complex assembly GO:0034622 9.58 FGG FGB FGA
22 fibrinolysis GO:0042730 9.54 FGG FGB FGA
23 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.5 FGG FGB FGA
24 protein polymerization GO:0051258 9.43 FGG FGB FGA
25 plasminogen activation GO:0031639 9.33 FGG FGB FGA
26 positive regulation of peptide hormone secretion GO:0090277 9.13 FGG FGB FGA
27 blood coagulation, fibrin clot formation GO:0072378 8.8 FGG FGB FGA

Molecular functions related to Fibrinogen Deficiency, Congenital according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.43 FGG FGB FGA
2 structural molecule activity GO:0005198 9.33 FGG FGB FGA
3 extracellular matrix structural constituent GO:0005201 9.13 FGG FGB FGA
4 cell adhesion molecule binding GO:0050839 8.8 FGG FGB FGA

Sources for Fibrinogen Deficiency, Congenital

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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