MCID: FBR091
MIFTS: 22

Fibroblastic Rheumatism

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Fibroblastic Rheumatism

MalaCards integrated aliases for Fibroblastic Rheumatism:

Name: Fibroblastic Rheumatism 59 73

Classifications:



External Ids:

Orphanet 59 ORPHA477650
UMLS 73 C1302753

Summaries for Fibroblastic Rheumatism

MalaCards based summary : Fibroblastic Rheumatism is related to langerhans cell histiocytosis and fibromatosis. An important gene associated with Fibroblastic Rheumatism is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Striated Muscle Contraction. Affiliated tissues include bone and skin, and related phenotype is cardiovascular system.

Related Diseases for Fibroblastic Rheumatism

Diseases related to Fibroblastic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 langerhans cell histiocytosis 29.2 CD163 F13A1
2 fibromatosis 29.2 ACTC1 DES
3 non-langerhans-cell histiocytosis 27.2 ACTC1 CD163 DES F13A1
4 progressive nodular histiocytosis 10.2 ACTC1 F13A1
5 scleromyxedema 10.2 ACTC1 F13A1
6 ovarian fibrothecoma 9.9 ACTC1 DES
7 cutaneous leiomyosarcoma 9.9 ACTC1 DES
8 botryoid rhabdomyosarcoma 9.9 ACTC1 DES
9 spindle cell lipoma 9.9 ACTC1 DES
10 parachordoma 9.8 ACTC1 DES
11 ossifying fibromyxoid tumor 9.8 ACTC1 DES
12 epithelioid leiomyosarcoma 9.8 ACTC1 DES
13 syringocystadenoma papilliferum 9.8 ACTC1 DES
14 benign metastasizing leiomyoma 9.8 ACTC1 DES
15 myofibroma 9.8 DES F13A1
16 congenital fibrosarcoma 9.8 ACTC1 DES
17 pulmonary vein stenosis 9.8 ACTC1 DES
18 cystic nephroma 9.8 ACTC1 DES
19 juvenile xanthogranuloma 9.8 DES F13A1
20 pleomorphic liposarcoma 9.8 ACTC1 DES
21 ischemic fasciitis 9.8 ACTC1 DES
22 perivascular epithelioid cell tumor 9.8 ACTC1 DES
23 reticulum cell sarcoma 9.8 ACTC1 DES
24 dedifferentiated liposarcoma 9.8 ACTC1 DES
25 glomus tumor 9.8 ACTC1 DES
26 spindle cell sarcoma 9.8 ACTC1 DES
27 pseudosarcomatous fibromatosis 9.8 ACTC1 DES
28 rhabdoid cancer 9.8 ACTC1 DES
29 smooth muscle tumor 9.7 ACTC1 DES
30 infantile myofibromatosis 9.7 ACTC1 DES
31 chondromyxoid fibroma 9.7 ACTC1 DES
32 fasciitis 9.7 ACTC1 DES
33 glomangioma 9.7 ACTC1 DES
34 angiomyolipoma 9.7 ACTC1 DES
35 spindle cell carcinoma 9.7 ACTC1 DES
36 familial isolated dilated cardiomyopathy 9.6 ACTC1 DES
37 atypical teratoid rhabdoid tumor 9.6 ACTC1 DES
38 multicentric reticulohistiocytosis 9.6
39 histiocytosis 9.6
40 inflammatory myofibroblastic tumor 9.6 ACTC1 DES
41 restrictive cardiomyopathy 9.6 ACTC1 DES
42 leiomyosarcoma 9.5 ACTC1 DES
43 endometrial stromal sarcoma 9.5 ACTC1 DES
44 leiomyoma 9.4 ACTC1 DES
45 left ventricular noncompaction 9.3 ACTC1 DES
46 angiolipoma 9.3 ACTC1 DES F13A1
47 hemangiopericytoma, malignant 9.3 ACTC1 DES F13A1
48 malignant fibroxanthoma 9.3 ACTC1 DES F13A1
49 dermatofibrosarcoma protuberans 9.2 ACTC1 DES F13A1
50 gastrointestinal stromal tumor 9.2 ACTC1 DES

Graphical network of the top 20 diseases related to Fibroblastic Rheumatism:



Diseases related to Fibroblastic Rheumatism

Symptoms & Phenotypes for Fibroblastic Rheumatism

MGI Mouse Phenotypes related to Fibroblastic Rheumatism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 8.92 ACTC1 CD163 DES F13A1

Drugs & Therapeutics for Fibroblastic Rheumatism

Search Clinical Trials , NIH Clinical Center for Fibroblastic Rheumatism

Genetic Tests for Fibroblastic Rheumatism

Anatomical Context for Fibroblastic Rheumatism

MalaCards organs/tissues related to Fibroblastic Rheumatism:

41
Bone, Skin

Publications for Fibroblastic Rheumatism

Articles related to Fibroblastic Rheumatism:

(show all 21)
# Title Authors Year
1
Fibroblastic rheumatism: A case of multiple nodules of fingers and hands, contractures of fingers and polyarthritis. ( 29314178 )
2018
2
Fibroblastic rheumatism: the first case with infiltration of multinuclear giant cells and raised blood lead level. ( 25545215 )
2015
3
Fibroblastic rheumatism: immunosuppressive therapy is not always required. ( 24112952 )
2014
4
Fibroblastic rheumatism - case report. ( 24141350 )
2013
5
An unusual case of polyarthritis, skin nodules and patchy skin thickening: fibroblastic rheumatism. ( 22324960 )
2012
6
Fibroblastic rheumatism: a report of 4 cases with potential therapeutic implications. ( 21982057 )
2012
7
Good clinical response to methotrexate treatment in a patient with fibroblastic rheumatism. ( 20340022 )
2012
8
Multicentric reticulohistiocytosis and fibroblastic rheumatism. ( 23040366 )
2012
9
Fibroblastic rheumatism: an addition to fibromatosis. ( 21549631 )
2011
10
Fibroblastic rheumatism: fibromatosis rather than non-Langerhans cell histiocytosis. ( 19615014 )
2010
11
An Asian case of fibroblastic rheumatism: clinical, radiological, and histological features. ( 20715301 )
2010
12
Response of fibroblastic rheumatism to infliximab. ( 20585484 )
2009
13
Fibroblastic rheumatism. ( 19076791 )
2009
14
Radiological bone lesions in fibroblastic rheumatism; case report. ( 17321366 )
2007
15
Fibroblastic rheumatism. ( 16891927 )
2006
16
Fibroblastic rheumatism: a Scandinavian case report. ( 15608318 )
2005
17
Proliferation characteristics and polyploidization of cultured myofibroblasts from a patient with fibroblastic rheumatism. ( 14514418 )
2003
18
Fibroblastic rheumatism: a variant of non-Langerhans cell histiocytoses? ( 14521576 )
2003
19
Fibroblastic rheumatism: case report and review of the literature. ( 12437558 )
2002
20
Fibroblastic rheumatism: a case without rheumatological symptoms. ( 12353712 )
2002
21
Fibroblastic rheumatism: clinical and histologic evolution of cutaneous manifestations. ( 9818674 )
1998

Variations for Fibroblastic Rheumatism

Expression for Fibroblastic Rheumatism

Search GEO for disease gene expression data for Fibroblastic Rheumatism.

Pathways for Fibroblastic Rheumatism

Pathways related to Fibroblastic Rheumatism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.19 ACTC1 DES
2 10.48 ACTC1 DES

GO Terms for Fibroblastic Rheumatism

Cellular components related to Fibroblastic Rheumatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.62 ACTC1 F13A1

Biological processes related to Fibroblastic Rheumatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.62 ACTC1 DES

Sources for Fibroblastic Rheumatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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