MCID: FBR019
MIFTS: 48

Fibromatosis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Fibromatosis

MalaCards integrated aliases for Fibromatosis:

Name: Fibromatosis 53 55 73

Classifications:



External Ids:

UMLS 73 C0016048

Summaries for Fibromatosis

NIH Rare Diseases : 53 Fibromatosis refers to a group of conditions characterized by overgrowths of skin and connective tissue called fibromas. These fibromas are usually benign (non-cancerous). Fibromatosis can be classified by a person's age or by the location of the fibromas. The cause of fibromatosis is often unknown, and treatment depends on the individual disease.

MalaCards based summary : Fibromatosis is related to infantile digital fibromatosis and desmoid disease, hereditary. An important gene associated with Fibromatosis is SOS1 (SOS Ras/Rac Guanine Nucleotide Exchange Factor 1), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and PI3K-Akt signaling pathway. The drugs Sorafenib and Nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and bone, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 The term fibromatosis refers to a group of soft tissue tumors which have certain characteristics in... more...

Related Diseases for Fibromatosis

Diseases related to Fibromatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 infantile digital fibromatosis 33.7 DES VIM
2 desmoid disease, hereditary 33.2 APC CTNNB1
3 desmoid tumor 33.2 APC CTNNB1 KIT
4 pseudosarcomatous fibromatosis 33.1 ACTC1 CTNNB1 DES VIM
5 infantile myofibromatosis 31.8 ACTC1 DES VIM
6 familial adenomatous polyposis 1 30.1 APC CTNNB1
7 fasciitis 29.9 ACTC1 DES VIM
8 benign breast phyllodes tumor 29.8 KIT VIM
9 fibroblastic rheumatism 29.7 ACTC1 DES
10 gingival hypertrophy 29.7 ANTXR2 VIM
11 gastrointestinal stromal tumor 29.7 ACTC1 DES KIT VIM
12 spindle cell carcinoma 29.6 ACTC1 DES VIM
13 non-langerhans-cell histiocytosis 29.5 ACTC1 DES
14 congenital fibrosarcoma 29.4 ACTC1 DES VIM
15 juvenile nasopharyngeal angiofibroma 29.4 ACTC1 KIT
16 fibrous histiocytoma 29.2 ACTC1 DES VIM
17 glomus tumor 29.2 ACTC1 DES VIM
18 malignant fibroxanthoma 29.2 ACTC1 DES VIM
19 rhabdomyosarcoma 29.2 ACTC1 DES VIM
20 inflammatory myofibroblastic tumor 28.9 ACTC1 DES KIT VIM
21 leiomyoma 28.9 ACTC1 DES KIT VIM
22 hyaline fibromatosis syndrome 12.6
23 fibromatosis, gingival, 1 12.6
24 fibromatosis, gingival, with progressive deafness 12.5
25 fibromatosis, gingival, 2 12.4
26 fibromatosis, gingival, 4 12.4
27 gingival fibromatosis 12.4
28 fibromatosis, gingival, 5 12.4
29 fibromatosis, gingival, 3 12.3
30 plantar fascial fibromatosis 12.2
31 fibromatosis, gingival, with distinctive facies 12.2
32 hypertrichosis, congenital generalized, with or without gingival hyperplasia 12.1
33 zimmermann-laband syndrome 1 12.1
34 ledderhose disease 12.1
35 dupuytren contracture 12.0
36 myofibromatosis, infantile, 1 12.0
37 fibromatosis, gingival, with hypertrichosis and mental retardation 11.9
38 fibromatosis multiple non ossifying 11.9
39 ramon syndrome 11.6
40 peritonitis 11.4
41 amelogenesis imperfecta, type ig 11.3
42 congenital torticollis 11.3
43 hyalinosis, inherited systemic 11.3
44 zimmermann-laband syndrome 11.3
45 rutherfurd syndrome 11.0
46 oculocerebral syndrome with hypopigmentation 11.0
47 zimmermann-laband syndrome 2 11.0
48 peyronie's disease 10.9
49 calcifying aponeurotic fibroma 10.9
50 sarcoma 10.3

Graphical network of the top 20 diseases related to Fibromatosis:



Diseases related to Fibromatosis

Symptoms & Phenotypes for Fibromatosis

MGI Mouse Phenotypes related to Fibromatosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 ACTC1 ANTXR2 APC CTNNB1 DES KIT
2 cellular MP:0005384 10.06 ACTC1 ANTXR2 APC CTNNB1 DES KIT
3 mortality/aging MP:0010768 9.97 ACTC1 ANTXR2 APC CTNNB1 DES KIT
4 embryo MP:0005380 9.85 APC CTNNB1 KIT REST SOS1 VIM
5 muscle MP:0005369 9.8 ACTC1 APC CTNNB1 DES KIT SOS1
6 no phenotypic analysis MP:0003012 9.55 ANTXR2 APC CTNNB1 KIT SOS1
7 reproductive system MP:0005389 9.43 ANTXR2 APC CTNNB1 KIT REST VIM
8 vision/eye MP:0005391 9.1 APC CTNNB1 KIT REST SOS1 VIM

Drugs & Therapeutics for Fibromatosis

Drugs for Fibromatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sorafenib Approved, Investigational Phase 3 284461-73-0 216239 406563
2
Nicotinamide Approved, Investigational Phase 3 98-92-0 936
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
4
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
5 Protein Kinase Inhibitors Phase 3,Phase 2,Phase 1
6 Vitamin B9 Phase 3,Phase 2
7 Folate Phase 3,Phase 2
8 Vitamin B Complex Phase 3,Phase 2
9 Vitamins Phase 3
10 Vitamin B3 Phase 3
11 Nicotinic Acids Phase 3
12 Trace Elements Phase 3
13 Micronutrients Phase 3
14
Toremifene Approved, Investigational Phase 2 89778-26-7 3005573
15
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
16
Vinblastine Approved Phase 2 865-21-4 241903 13342
17
leucovorin Approved Phase 2 58-05-9 6006 143
18
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
19
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
20
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
21
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
22
Aminolevulinic acid Approved Phase 2 106-60-5 137
23
Nivolumab Approved Phase 2 946414-94-4
24
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
25
Sulindac Approved, Investigational Phase 2 38194-50-2 5352 1548887
26
Tamoxifen Approved Phase 2,Phase 1 10540-29-1 2733526
27
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
28 Antineoplastic Agents, Hormonal Phase 2,Phase 1
29 Hormones Phase 2,Phase 1,Early Phase 1
30 Selective Estrogen Receptor Modulators Phase 2,Phase 1
31 Estrogens Phase 2,Phase 1,Early Phase 1
32 Hormone Antagonists Phase 2,Phase 1,Early Phase 1
33 Estrogen Receptor Modulators Phase 2,Phase 1
34 Bone Density Conservation Agents Phase 2,Phase 1
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1,Early Phase 1
36 Imatinib Mesylate Phase 2,Phase 1 220127-57-1 123596
37 Antimetabolites Phase 2
38 Antirheumatic Agents Phase 2
39 Folic Acid Antagonists Phase 2
40 Antineoplastic Agents, Phytogenic Phase 2
41 Immunologic Factors Phase 2,Phase 1
42 Immunosuppressive Agents Phase 2,Phase 1
43 Dermatologic Agents Phase 2
44 Antimitotic Agents Phase 2
45 Antimetabolites, Antineoplastic Phase 2
46 Nucleic Acid Synthesis Inhibitors Phase 2
47 Angiogenesis Modulating Agents Phase 2
48 Angiogenesis Inhibitors Phase 2
49 Calcium, Dietary Phase 2
50 Antibiotics, Antitubercular Phase 1, Phase 2

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 Prospective Trial Comparing the Performance Profiles of Two Non-Cross-Linked Porcine Dermal Matrices in Abdominal Wall Reconstruction Recruiting NCT02228889 Phase 4
2 Ledderhose Disease: Radiotherapy or Not? Recruiting NCT03507010 Phase 3
3 Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis Active, not recruiting NCT02066181 Phase 3 Sorafenib Tosylate
4 Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) Not yet recruiting NCT03785964 Phase 3 Nirogacestat oral tablet;Placebo Oral Tablet
5 Toremifene in Desmoid Tumor: Prospective Clinical Trial and Identification of Potential Molecular Targets Unknown status NCT02353429 Phase 2 Toremifene
6 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
7 A Trial of Imatinib for Patients With Aggressive Desmoid Tumor (Aggressive Fibromatosis) Completed NCT02495519 Phase 2 Imatinib
8 Imatinib Mesylate in Treating Patients With Recurrent or Refractory Fibromatosis Completed NCT00287846 Phase 1, Phase 2 imatinib mesylate
9 Radiation Therapy in Treating Patients With Aggressive Fibromatoses Completed NCT00030680 Phase 2
10 Study to Evaluate Imatinib in Desmoid Tumors Completed NCT01137916 Phase 2 Imatinib
11 Vinblastine and Methotrexate in Treating Children With Desmoid Tumors Completed NCT00003019 Phase 2 methotrexate;vinblastine sulfate
12 Toremifene in Treating Patients With Desmoid Tumors Completed NCT00002595 Phase 2 toremifene
13 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
14 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
15 A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis Recruiting NCT01265030 Phase 1, Phase 2 Sirolimus
16 Safety and Efficacy Study Using 5-ALA Oral Administration as an Adjuvant Therapy on the Rate of Local Tumor Recurrence in Patients Who Have Desmoids Tumors Recruiting NCT01898416 Phase 2 5-AMINOLEVULINIC ACID (5-ALA), is a non fluorescent prodrug.
17 PAZOPANIB Efficacy and Tolerance in Desmoids Tumors Recruiting NCT01876082 Phase 2 PAZOPANIB treatment;Active Comparator: Vinblastine and Methotrexate
18 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
19 Trial of Nab-paclitaxel in Patients With Desmoid Tumors and Multiply Relapsed/Refractory Desmoplastic Small Round Cell Tumors and Ewing Sarcoma Recruiting NCT03275818 Phase 2 nab paclitaxel
20 Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies Recruiting NCT03422679 Phase 1, Phase 2 CB-103
21 Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive Fibromatosis Active, not recruiting NCT01981551 Phase 2 PF-03084014
22 Sulindac and Tamoxifen in Treating Patients With Desmoid Tumor Active, not recruiting NCT00068419 Phase 2 tamoxifen citrate;sulindac
23 Imatinib in Patients With Desmoid Tumor and Chondrosarcoma Active, not recruiting NCT00928525 Phase 2 Imatinib Mesylate
24 A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor Not yet recruiting NCT03802084 Phase 1, Phase 2 vactosertib/imatinib combination
25 Effect of Hydroxyurea as Treatment for Primary Desmoid Tumors Withdrawn NCT00978146 Phase 2 Hydroxyurea
26 A Pilot Study of Intralesional Injection of Triamcinolone Acetonide for Desmoid Tumors Recruiting NCT03627741 Phase 1 Triamcinolone Acetonide
27 Phase I, Open-label, Non-randomized Study to Evaluate Safety of BC2059 Recruiting NCT03459469 Phase 1 Tegavivint
28 MR-guided High Intensity Focused Ultrasound (HIFU) on Pediatric Solid Tumors Recruiting NCT02076906 Phase 1
29 Endoxifen in Adults With Hormone Receptor Positive Solid Tumors Active, not recruiting NCT01273168 Phase 1 Z-Endoxifen
30 Peripheral Primitive Fibromatosis Unknown status NCT01801176 Not Applicable
31 Tailored Beta-catenin Mutational Approach in Extra-abdominal Sporadic Desmoids Tumor Patients Unknown status NCT02547831
32 Knee Stiffness in Fibrosis Diathesis Unknown status NCT02294890
33 Genes Associated With Hereditary and Drug-Induced Gingival Overgrowth Completed NCT00104026
34 Evaluation of the Cryodestruction of Non Abdominopelvic Desmoid Tumors in Patients Progressing Despite Medical Treatment Completed NCT02476305 Not Applicable
35 A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome Completed NCT01286662
36 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
37 Biomarker for Hyaline Fibromatosis Syndrome Recruiting NCT03196115
38 National Clinical-biological Prospective Cohort of Incident Cases of Aggressive Fibromatosis (ALTITUDES) Recruiting NCT02867033 Not Applicable
39 Optional Sub-study to Intraoperative Imaging With ICG Registry Recruiting NCT02651246
40 Project: Every Child for Younger Patients With Cancer Recruiting NCT02402244
41 18F-FES PET/CT in Imaging Patients With Desmoid Tumors Active, not recruiting NCT02374931 Early Phase 1 F-18 16 Alpha-Fluoroestradiol
42 Natural Disease Progress of Dupuytren Disease Active, not recruiting NCT01923103
43 Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Active, not recruiting NCT00919269
44 Compassionate Use Protocol for PF-03084014 in Patients With Advanced Solid Tumor Malignancies No longer available NCT02955446 PF-03084014

Search NIH Clinical Center for Fibromatosis

Genetic Tests for Fibromatosis

Anatomical Context for Fibromatosis

MalaCards organs/tissues related to Fibromatosis:

41
Breast, Skin, Bone, Lymph Node, Thyroid, Lung, Tongue

Publications for Fibromatosis

Articles related to Fibromatosis:

(show top 50) (show all 1283)
# Title Authors Year
1
Evidence of hydroxyurea activity in children with pretreated desmoid-type fibromatosis: A new option in the armamentarium of systemic therapies. ( 30270493 )
2019
2
Optimal management of desmoid fibromatosis. ( 29926797 )
2018
3
Corticosteroid inhibits differentiation of palmar fibromatosis-derived stem cells (FSCs) through downregulation of transforming growth factor-I^1 (TGF-I^1). ( 29944666 )
2018
4
Systemic therapy of aggressive fibromatosis in children and adolescents: Report of the Cooperative Weichteilsarkom Studiengruppe (CWS). ( 29316163 )
2018
5
Optimal radiotherapy strategy for primary or recurrent fibromatosis and long-term results. ( 29813130 )
2018
6
Unexpected Hydronephrosis: Mesenteric Fibromatosis. ( 29730360 )
2018
7
Plantar fibromatosis: Surgical approach of a giant bilateral case. ( 29265359 )
2018
8
Expression of CD163 in hereditary gingival fibromatosis: A possible association with TGF-I^1. ( 29325232 )
2018
9
Gene expression profiling and bioinformatics analysis of hereditary gingival fibromatosis. ( 29435271 )
2018
10
A large and aggressive fibromatosis in the axilla: a rare case report and review of the literature. ( 29881291 )
2018
11
Successful Management of Aggressive Fibromatosis of the Neck: A Case Report ( 29843498 )
2018
12
Hyaline fibromatosis syndrome (juvenile hyaline fibromatosis): whole-body MR findings in two siblings with different subcutaneous nodules distribution. ( 29058046 )
2018
13
Marginal versus segmental mandibulectomy for pediatric desmoid fibromatosis of the mandible - Two case reports and review of the literature. ( 29728178 )
2018
14
Sporadic Abdominal Wall Desmoid type Fibromatosis: treatment paradigm after thirty two years. ( 29879959 )
2018
15
Aggressive fibromatosis response to tamoxifen: lack of correlation between MRI and symptomatic response. ( 29785261 )
2018
16
Infantile digital fibromatosis-like tumor of adult. ( 29319280 )
2018
17
Novel intra-genic large deletions of CTNNB1 gene identified in WT desmoid-type fibromatosis. ( 29901254 )
2018
18
Plantar Fibromatosis: Pathophysiology, Surgical and Nonsurgical Therapies: An Evidence-Based Review. ( 29310463 )
2018
19
Orbital Desmoid-Type Fibromatosis: A Case Report and Literature Review. ( 29707396 )
2018
20
The Use of Cryotherapy to Treat Infantile Digital Fibromatosis with a Functional Deficit: A Case Report. ( 29734898 )
2018
21
Aggressive breast fibromatosis following augmentation mastoplasty: a series of case reports. ( 29910830 )
2018
22
The genetic basis of hyaline fibromatosis syndrome in patients from a consanguineous background: a case series. ( 29801470 )
2018
23
An unusual finding in a desmoid-type fibromatosis of the pancreas: a case report and review of the literature. ( 29751773 )
2018
24
Sporadic Desmoid-Type Fibromatosis Occurring at Laparoscopic Trocar Site: An Unusual Entity. ( 29973760 )
2018
25
APC mosaicism in a young woman with desmoid type fibromatosis and familial adenomatous polyposis. ( 29368261 )
2018
26
Radiation Therapy as an Alternative Treatment for Desmoid Fibromatosis. ( 29803344 )
2018
27
Mesenteric fibromatosis: a rare cause of peritonitis. ( 29424348 )
2018
28
Erosive Arthritis, Fibromatosis, and Keloids: A Rare Dermatoarthropathy. ( 29850357 )
2018
29
Sternocleidomastoid tumour in neonate:<i>fibromatosis colli</i>. ( 29326344 )
2018
30
Phase II study of doxorubicin and thalidomide in patients with refractory aggressive fibromatosis. ( 29170886 )
2018
31
A clinically functioning gonadotroph adenoma presenting with abdominal pain, ovarian hyperstimulation and fibromatosis. ( 30532999 )
2018
32
Ultrasound Features of Palmar Fibromatosis or Dupuytren Contracture. ( 30027660 )
2018
33
Bilateral breast fibromatosis after silicone prosthetics in a patient with classic familial adenomatous polyposis: A case report. ( 30008823 )
2018
34
Identification and assessment of health-related quality of life issues in patients with sporadic desmoid-type fibromatosis: a literature review and focus group study. ( 30014458 )
2018
35
Outcome of Nonsurgical Management of Extra-Abdominal, Trunk, and Abdominal Wall Desmoid-Type Fibromatosis: A Population-Based Study in the Netherlands. ( 30034268 )
2018
36
Correlation between tumor growth and hormonal therapy with MR signal characteristics of desmoid-type fibromatosis: A preliminary study. ( 30037746 )
2018
37
Chest Wall Fibromatosis with Congenital Muscular Torticollis: Two Forms of Deep Fibromatosis in a Child. ( 30050265 )
2018
38
Four different treatment strategies in aggressive fibromatosis: A systematic review. ( 30069502 )
2018
39
Nonsyndromic Gingival Fibromatosis: A Rare Case Report. ( 30131651 )
2018
40
Mesenteric fibromatosis misdiagnosed with lymph node metastasis after successful laparoscopic right hemicolectomy: a report of two cases with review of literature. ( 30147332 )
2018
41
Two novel mutations in the ANTXR2 gene in a Chinese patient suffering from hyaline fibromatosis syndrome: A case report. ( 30152846 )
2018
42
Desmoid fibromatosis through the patients' eyes: time to change the focus and organisation of care? ( 30155568 )
2018
43
Laparoscopic Resection of Desmoid Type Fibromatosis of the Splenic Hilum Mimicking a Greater Curvature Gastric GIST. ( 30158041 )
2018
44
Juvenile Hyaline Fibromatosis. ( 30166849 )
2018
45
Desmoid fibromatosis of the esophagogastric junction. ( 30168335 )
2018
46
Recurrent desmoid-type fibromatosis associated with underlying neuromuscular choristoma. ( 30168738 )
2018
47
Hyaline fibromatosis syndrome: Clinical update and phenotype-genotype correlations. ( 30176098 )
2018
48
Mesenteric fibromatosis in a patient with a history of neuroblastoma: a case report. ( 30186589 )
2018
49
Current Update on Desmoid Fibromatosis. ( 30211798 )
2018
50
Immunohistochemical and Molecular Analyses Focusing on Mesenchymal Cells in Papillary Thyroid Carcinoma with Desmoid-Type Fibromatosis. ( 30223266 )
2018

Variations for Fibromatosis

Cosmic variations for Fibromatosis:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM575 NRAS soft tissue,skin,sarcoma,NS c.38G>C p.G13A 1:114716123-114716123 3

Expression for Fibromatosis

Search GEO for disease gene expression data for Fibromatosis.

Pathways for Fibromatosis

Pathways related to Fibromatosis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 APC CTNNB1 KIT SOS1 VIM
2
Show member pathways
12.73 APC CTNNB1 KIT SOS1
3
Show member pathways
12.61 APC CTNNB1 KIT SOS1
4 12.57 APC CTNNB1 KIT SOS1
5
Show member pathways
12.44 APC CTNNB1 KIT SOS1
6
Show member pathways
12.19 APC CTNNB1 KIT
7
Show member pathways
12.09 APC CTNNB1 KIT SOS1
8 11.92 APC CTNNB1 SOS1
9 11.85 APC CTNNB1 REST VIM
10 11.78 APC CTNNB1 REST
11
Show member pathways
11.64 APC CTNNB1 VIM
12 11.6 APC CTNNB1 SOS1
13 11.54 APC CTNNB1 SOS1
14
Show member pathways
11.49 APC CTNNB1 REST VIM
15 11.24 APC CTNNB1
16 11.2 ACTC1 CTNNB1
17 11.09 CTNNB1 VIM
18 11.05 APC CTNNB1
19 10.99 ACTC1 DES VIM
20 10.94 APC CTNNB1
21 10.77 APC CTNNB1
22 10.64 KIT SOS1
23 10.63 APC CTNNB1 SOS1

GO Terms for Fibromatosis

Cellular components related to Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.91 ACTC1 APC CTNNB1 DES KIT REST
2 cytoskeleton GO:0005856 9.85 ACTC1 APC CTNNB1 DES VIM
3 lamellipodium GO:0030027 9.54 ACTC1 APC CTNNB1
4 cell-cell junction GO:0005911 9.5 CTNNB1 DES KIT
5 catenin complex GO:0016342 9.4 APC CTNNB1
6 beta-catenin destruction complex GO:0030877 9.16 APC CTNNB1
7 fascia adherens GO:0005916 8.96 CTNNB1 DES
8 Wnt signalosome GO:1990909 8.62 APC CTNNB1
9 cytosol GO:0005829 10.03 ACTC1 APC CTNNB1 DES REST SAMD9

Biological processes related to Fibromatosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 ACTC1 CTNNB1 KIT VIM
2 regulation of cell differentiation GO:0045595 9.51 APC CTNNB1
3 T cell differentiation GO:0030217 9.49 CTNNB1 KIT
4 negative regulation of neurogenesis GO:0050768 9.48 CTNNB1 REST
5 beta-catenin destruction complex disassembly GO:1904886 9.46 APC CTNNB1
6 positive regulation of apoptotic process GO:0043065 9.46 APC CTNNB1 REST SOS1
7 cell fate specification GO:0001708 9.43 APC CTNNB1
8 intermediate filament organization GO:0045109 9.4 DES VIM
9 regulation of osteoblast differentiation GO:0045667 9.32 CTNNB1 REST
10 positive regulation of pseudopodium assembly GO:0031274 9.26 APC KIT
11 regulation of T cell proliferation GO:0042129 8.96 CTNNB1 SOS1
12 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Sources for Fibromatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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