MCID: FBR079
MIFTS: 22

Fibromatosis, Gingival, 2

Categories: Rare diseases, Genetic diseases, Oral diseases

Aliases & Classifications for Fibromatosis, Gingival, 2

MalaCards integrated aliases for Fibromatosis, Gingival, 2:

Name: Fibromatosis, Gingival, 2 57 13 73
Gingf2 57 53
Ggf2 57 53
Hgf2 57 53
Fibromatosis, Gingival, Hereditary, 2; Hgf2 57
Fibromatosis, Gingival, Hereditary, 2 57
Fibromatosis Gingival, Hereditary, 2 53
Hereditary Gingival Fibromatosis, 2 53
Gingival Fibromatosis, 2 53
Gingival Fibromatosis 2 29

Classifications:



External Ids:

OMIM 57 605544
MedGen 42 C1854181
UMLS 73 C1854181

Summaries for Fibromatosis, Gingival, 2

OMIM : 57 Hereditary gingival fibromatosis is a benign disorder manifested by a slowly progressive enlargement of the oral gingival tissues (summary by Xiao et al., 2001). For general phenotypic information and a discussion of genetic heterogeneity of hereditary gingival fibromatosis, see GINGF (135300). (605544)

MalaCards based summary : Fibromatosis, Gingival, 2, also known as gingf2, is related to gingival fibromatosis and myocardial infarction. An important gene associated with Fibromatosis, Gingival, 2 is GINGF2 (Gingival Fibromatosis, Hereditary, 2). The drugs Midazolam and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include heart.

Related Diseases for Fibromatosis, Gingival, 2

Diseases in the Gingival Fibromatosis family:

Fibromatosis, Gingival, 1 Fibromatosis, Gingival, 2
Fibromatosis, Gingival, 3 Fibromatosis, Gingival, 4
Fibromatosis, Gingival, 5

Diseases related to Fibromatosis, Gingival, 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 gingival fibromatosis 11.6
2 myocardial infarction 9.9
3 spinal cord injury 9.9
4 neuronitis 9.9
5 fibromatosis, gingival, 1 9.9
6 gingivitis 9.9
7 fibromatosis 9.9

Graphical network of the top 20 diseases related to Fibromatosis, Gingival, 2:



Diseases related to Fibromatosis, Gingival, 2

Symptoms & Phenotypes for Fibromatosis, Gingival, 2

Clinical features from OMIM:

605544

Drugs & Therapeutics for Fibromatosis, Gingival, 2

Drugs for Fibromatosis, Gingival, 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
2 Mitogens Phase 1
3 Adjuvants, Anesthesia Phase 1
4 Anesthetics Phase 1
5 Anesthetics, General Phase 1
6 Anesthetics, Intravenous Phase 1
7 Anti-Anxiety Agents Phase 1
8 Central Nervous System Depressants Phase 1
9 GABA Agents Phase 1
10 GABA Modulators Phase 1
11 Hypnotics and Sedatives Phase 1
12 Neurotransmitter Agents Phase 1
13 Psychotropic Drugs Phase 1
14 Tranquilizing Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single Ascending Doses of GGF2 in Patients With Left Ventricular Dysfunction and Symptomatic Heart Failure Completed NCT01258387 Phase 1 Glial growth factor 2/ Neuregulin 1β3
2 A Double-Blind Pharmacokinetic Interaction Study Evaluating the Effect of a Single IV Infusion of GGF2 or Placebo on Midazolam Pharmacokinetics in Patients With Heart Failure Completed NCT01944683 Phase 1 GGF2;Midazolam

Search NIH Clinical Center for Fibromatosis, Gingival, 2

Genetic Tests for Fibromatosis, Gingival, 2

Genetic tests related to Fibromatosis, Gingival, 2:

# Genetic test Affiliating Genes
1 Gingival Fibromatosis 2 29

Anatomical Context for Fibromatosis, Gingival, 2

MalaCards organs/tissues related to Fibromatosis, Gingival, 2:

41
Heart

Publications for Fibromatosis, Gingival, 2

Variations for Fibromatosis, Gingival, 2

Expression for Fibromatosis, Gingival, 2

Search GEO for disease gene expression data for Fibromatosis, Gingival, 2.

Pathways for Fibromatosis, Gingival, 2

GO Terms for Fibromatosis, Gingival, 2

Sources for Fibromatosis, Gingival, 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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