GINGF2
MCID: FBR079
MIFTS: 20

Fibromatosis, Gingival, 2 (GINGF2)

Categories: Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Fibromatosis, Gingival, 2

MalaCards integrated aliases for Fibromatosis, Gingival, 2:

Name: Fibromatosis, Gingival, 2 57 13 70
Gingf2 57 20
Ggf2 57 20
Hgf2 57 20
Fibromatosis, Gingival, Hereditary, 2; Hgf2 57
Fibromatosis, Gingival, Hereditary, 2 57
Fibromatosis Gingival, Hereditary, 2 20
Hereditary Gingival Fibromatosis, 2 20
Gingival Fibromatosis, 2 20
Gingival Fibromatosis 2 29

Classifications:



External Ids:

OMIM® 57 605544
OMIM Phenotypic Series 57 PS135300
MedGen 41 C1854181
UMLS 70 C1854181

Summaries for Fibromatosis, Gingival, 2

OMIM® : 57 Hereditary gingival fibromatosis is a benign disorder manifested by a slowly progressive enlargement of the oral gingival tissues (summary by Xiao et al., 2001). For general phenotypic information and a discussion of genetic heterogeneity of hereditary gingival fibromatosis, see GINGF (135300). (605544) (Updated 05-Apr-2021)

MalaCards based summary : Fibromatosis, Gingival, 2, also known as gingf2, is related to gingival fibromatosis and fibromatosis. An important gene associated with Fibromatosis, Gingival, 2 is GINGF2 (Gingival Fibromatosis, Hereditary, 2). The drugs Midazolam and Mitogens have been mentioned in the context of this disorder.

Related Diseases for Fibromatosis, Gingival, 2

Diseases in the Gingival Fibromatosis family:

Fibromatosis, Gingival, 1 Fibromatosis, Gingival, 2
Fibromatosis, Gingival, 3 Fibromatosis, Gingival, 4
Fibromatosis, Gingival, 5

Diseases related to Fibromatosis, Gingival, 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 gingival fibromatosis 11.1
2 fibromatosis 11.1
3 myocardial infarction 10.1
4 spinal cord injury 10.1
5 fibromatosis, gingival, 1 9.9
6 hypertrichosis, congenital generalized, with or without gingival hyperplasia 9.9
7 stroke, ischemic 9.9
8 fibromatosis, gingival, 4 9.9
9 impotence 9.9
10 demyelinating disease 9.9
11 hypertrichosis 9.9
12 allergic encephalomyelitis 9.9

Graphical network of the top 20 diseases related to Fibromatosis, Gingival, 2:



Diseases related to Fibromatosis, Gingival, 2

Symptoms & Phenotypes for Fibromatosis, Gingival, 2

Clinical features from OMIM®:

605544 (Updated 05-Apr-2021)

Drugs & Therapeutics for Fibromatosis, Gingival, 2

Drugs for Fibromatosis, Gingival, 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
2 Mitogens Phase 1
3 Neurotransmitter Agents Phase 1
4 Psychotropic Drugs Phase 1
5 Hypnotics and Sedatives Phase 1
6 Anesthetics Phase 1
7 Anesthetics, General Phase 1
8 GABA Modulators Phase 1
9 Anesthetics, Intravenous Phase 1
10 Anti-Anxiety Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 1, Double-Blind, Placebo-Controlled Study of Single Ascending Doses of GGF2 in Patients With Left Ventricular Dysfunction and Symptomatic Heart Failure Completed NCT01258387 Phase 1 Glial growth factor 2/ Neuregulin 1β3
2 Phase 1b Study of Pharmacokinetic Interaction, Evaluating the Effect of a Single IV Infusion of GGF2 or Placebo on Midazolam Pharmacokinetics in Patients With Heart Failure Completed NCT01944683 Phase 1 GGF2;Midazolam

Search NIH Clinical Center for Fibromatosis, Gingival, 2

Genetic Tests for Fibromatosis, Gingival, 2

Genetic tests related to Fibromatosis, Gingival, 2:

# Genetic test Affiliating Genes
1 Gingival Fibromatosis 2 29

Anatomical Context for Fibromatosis, Gingival, 2

Publications for Fibromatosis, Gingival, 2

Articles related to Fibromatosis, Gingival, 2:

# Title Authors PMID Year
1
A new locus for hereditary gingival fibromatosis (GINGF2) maps to 5q13-q22. 61 57
11386754 2001
2
A novel locus for autosomal dominant hereditary gingival fibromatosis, GINGF3, maps to chromosome 2p22.3-p23.3. 61
16098013 2005

Variations for Fibromatosis, Gingival, 2

Expression for Fibromatosis, Gingival, 2

Search GEO for disease gene expression data for Fibromatosis, Gingival, 2.

Pathways for Fibromatosis, Gingival, 2

GO Terms for Fibromatosis, Gingival, 2

Sources for Fibromatosis, Gingival, 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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